Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	Rab GDP-dissociation inhibitor activity	GDI1 GDI2	5.42e-06	2	47	2	GO:0005093
GeneOntologyMolecularFunction	cytoskeletal anchor activity	SYN1 GAS2L3 GAS2	2.39e-05	24	47	3	GO:0008093
GeneOntologyMolecularFunction	DNA/DNA annealing activity	BLM SMARCA1	2.94e-04	11	47	2	GO:1990814
GeneOntologyMolecularFunction	annealing activity	BLM SMARCA1	4.85e-04	14	47	2	GO:0140666
GeneOntologyMolecularFunction	GDP-dissociation inhibitor activity	GDI1 GDI2	7.21e-04	17	47	2	GO:0005092
GeneOntologyMolecularFunction	magnesium ion binding	MAP3K20 GTPBP10 HPRT1 PPM1A	2.69e-03	247	47	4	GO:0000287
Domain	RabGDI	GDI1 GDI2	6.20e-06	2	47	2	IPR000806
Domain	GDP_dissociation_inhibitor	GDI1 GDI2	3.71e-05	4	47	2	IPR018203
Domain	GDI	GDI1 GDI2	3.71e-05	4	47	2	PF00996
Domain	GAR	GAS2L3 GAS2	9.24e-05	6	47	2	PS51460
Domain	-	GAS2L3 GAS2	9.24e-05	6	47	2	3.30.920.20
Domain	GAS_dom	GAS2L3 GAS2	9.24e-05	6	47	2	IPR003108
Domain	GAS2	GAS2L3 GAS2	9.24e-05	6	47	2	PF02187
Domain	GAS2	GAS2L3 GAS2	9.24e-05	6	47	2	SM00243
Domain	zf-C2H2	BCL11B ZNF366 CASZ1 ZNF710 ZBTB43 ZNF513 ZNF114	1.62e-03	693	47	7	PF00096
Domain	ZINC_FINGER_C2H2_2	BCL11B ZNF366 CASZ1 ZNF710 ZBTB43 ZNF513 ZNF114	3.05e-03	775	47	7	PS50157
Domain	ZINC_FINGER_C2H2_1	BCL11B ZNF366 CASZ1 ZNF710 ZBTB43 ZNF513 ZNF114	3.09e-03	777	47	7	PS00028
Domain	Znf_C2H2-like	BCL11B ZNF366 CASZ1 ZNF710 ZBTB43 ZNF513 ZNF114	3.53e-03	796	47	7	IPR015880
Domain	Znf_C2H2	BCL11B ZNF366 CASZ1 ZNF710 ZBTB43 ZNF513 ZNF114	3.76e-03	805	47	7	IPR007087
Domain	ZnF_C2H2	BCL11B ZNF366 CASZ1 ZNF710 ZBTB43 ZNF513 ZNF114	3.84e-03	808	47	7	SM00355
Domain	DEAH_ATP_HELICASE	BLM SMARCA1	4.11e-03	38	47	2	PS00690
Domain	-	BCL11B ZNF366 ZNF710 ZBTB43 ZNF513 ZNF114	6.82e-03	679	47	6	3.30.160.60
Pubmed	Small scale genetic alterations contribute to increased mutability at the X-linked Hprt locus in vivo in Blm hypomorphic mice.	BLM HPRT1	1.79e-06	2	47	2	20299287
Pubmed	Cloning of a brain-type isoform of human Rab GDI and its expression in human neuroblastoma cell lines and tumor specimens.	GDI1 GDI2	1.79e-06	2	47	2	7585614
Pubmed	Phosphorylation of the N-terminal domain regulates subcellular localization and DNA binding properties of the peptidyl-prolyl cis/trans isomerase hPar14.	CSNK2A2 PIN4	5.36e-06	3	47	2	12860119
Pubmed	Cloning, characterization, and expression of a novel GDP dissociation inhibitor isoform from skeletal muscle.	GDI1 GDI2	5.36e-06	3	47	2	7513052
Pubmed	RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii.	GDI1 GDI2	5.36e-06	3	47	2	26240314
Pubmed	Striatal neurodevelopment is dysregulated in purine metabolism deficiency and impacts DARPP-32, BDNF/TrkB expression and signaling: new insights on the molecular and cellular basis of Lesch-Nyhan Syndrome.	BCL11B HPRT1	5.36e-06	3	47	2	24804781
Pubmed	Expression patterns of two human genes coding for different rab GDP-dissociation inhibitors (GDIs), extremely conserved proteins involved in cellular transport.	GDI1 GDI2	5.36e-06	3	47	2	7543319
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	BLM SMARCA1 PCYT1A PHIP CASZ1 CSNK2A2 PIN4	1.65e-05	608	47	7	36089195
Pubmed	Comparison of the gene expression profiles from normal and Fgfrl1 deficient mouse kidneys reveals downstream targets of Fgfrl1 signaling.	KRT23 DACH1 HEY1	1.74e-05	37	47	3	22432025
Pubmed	Characterization of novel Rab6-interacting proteins involved in endosome-to-TGN transport.	GDI1 GDI2	1.78e-05	5	47	2	11929610
Pubmed	GDI-1 preferably interacts with Rab10 in insulin-stimulated GLUT4 translocation.	GDI1 GDI2	1.78e-05	5	47	2	19570034
Pubmed	Intra-nuclear trafficking of the BLM helicase to DNA damage-induced foci is regulated by SUMO modification.	BLM SYN1	1.78e-05	5	47	2	15829507
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	WDR19 GAS2L3 GDI1 AZIN2 NDUFS2 CASZ1 CSNK2A2	2.25e-05	638	47	7	31182584
Pubmed	Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.	FAM50B MAP3K20 MED18 GNE ZNF366 CSNK2A2 HPRT1 PIN4 ZBTB43 ZNF114	2.28e-05	1477	47	10	31515488
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	MAP3K20 BLM STRN3 PARN SLC12A2 GTPBP10 NDUFS2 CEP164 CASZ1 CSNK2A2	2.55e-05	1497	47	10	31527615
Pubmed	The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function.	GDI1 GDI2	2.67e-05	6	47	2	11809807
Pubmed	Role of Rab3 GDP/GTP exchange protein in synaptic vesicle trafficking at the mouse neuromuscular junction.	SYN1 GDI1	3.74e-05	7	47	2	11359932
Pubmed	Respiratory Network Stability and Modulatory Response to Substance P Require Nalcn.	NALCN HPRT1	6.40e-05	9	47	2	28392070
Pubmed	Normal development in mice over-expressing the intracellular domain of DLL1 argues against reverse signaling by DLL1 in vivo.	HEY1 HPRT1	7.99e-05	10	47	2	24167636
Pubmed	Conditional knockout of protein O-mannosyltransferase 2 reveals tissue-specific roles of O-mannosyl glycosylation in brain development.	BCL11B HPRT1	1.17e-04	12	47	2	21452199
Pubmed	TBX2 specifies and maintains inner hair and supporting cell fate in the Organ of Corti.	BCL11B HPRT1	1.38e-04	13	47	2	36494345
Pubmed	Essential functions of synapsins I and II in synaptic vesicle regulation.	SYN1 HPRT1	1.38e-04	13	47	2	7777057
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	BLM DACH1 STRN3 SLC12A2 LUC7L3 GTPBP10 GDI2 PHIP NDUFS2	1.53e-04	1496	47	9	32877691
Pubmed	Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus.	BCL11B SLC12A2	1.86e-04	15	47	2	35379995
Pubmed	Loss of RNA-Binding Protein HuR Leads to Defective Ependymal Cells and Hydrocephalus.	BCL11B CEP164	2.12e-04	16	47	2	34815315
Pubmed	Heterogeneous nuclear ribonucleoprotein A3 controls mitotic progression of neural progenitors via interaction with cohesin.	SYN1 BCL11B	2.12e-04	16	47	2	32321712
Pubmed	SETD5 Regulates Chromatin Methylation State and Preserves Global Transcriptional Fidelity during Brain Development and Neuronal Wiring.	SYN1 BCL11B	2.12e-04	16	47	2	31515109
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	BLM PARN GDI1 GDI2 PHIP CSNK2A2	2.39e-04	653	47	6	22586326
Pubmed	Snf2l regulates Foxg1-dependent progenitor cell expansion in the developing brain.	SMARCA1 BCL11B	2.70e-04	18	47	2	22516202
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	DACH1 AZIN2 ZNF862 CASZ1	2.79e-04	233	47	4	37704626
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	SYN1 STRN3 PARN BCL11B GDI1 GDI2 CSNK2A2	2.92e-04	963	47	7	28671696
Pubmed	Presenilin enhancer 2 is crucial for the transition of apical progenitors into neurons but into not basal progenitors in the developing hippocampus.	BCL11B HEY1	3.01e-04	19	47	2	35575074
Pubmed	SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression.	HMGCR HPRT1	3.01e-04	19	47	2	26685326
Pubmed	DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity.	WDR19 SMARCA1 MED18	3.31e-04	99	47	3	34161765
Pubmed	Loss of neurodevelopmental-associated miR-592 impairs neurogenesis and causes social interaction deficits.	SYN1 BCL11B	3.34e-04	20	47	2	35365601
Pubmed	Phosphorylation of the chromatin remodeling factor DPF3a induces cardiac hypertrophy through releasing HEY repressors from DNA.	HEY1 CSNK2A2	3.69e-04	21	47	2	26582913
Pubmed	Nephronophthisis-Related Ciliopathies	WDR19 CEP164	3.69e-04	21	47	2	27336129
Pubmed	Snf2h Drives Chromatin Remodeling to Prime Upper Layer Cortical Neuron Development.	SMARCA1 BCL11B	3.69e-04	21	47	2	31680852
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	FAM50B BLM PCYT1A MED18 PARN GDI2 CSNK2A2	3.99e-04	1014	47	7	32416067
Pubmed	The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair.	PCYT1A MED18 PARN	4.05e-04	106	47	3	31024071
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	MAP3K20 SMARCA1 MED18 LUC7L3 GAS2L3 GTPBP10 CSNK2A2 PIN4	4.56e-04	1371	47	8	36244648
Pubmed	SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation.	SMARCA1 HPRT1	4.84e-04	24	47	2	18425126
Pubmed	Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt.	HMGCR LUC7L3 GDI1 GDI2	4.94e-04	271	47	4	25737280
Pubmed	Centrosome anchoring regulates progenitor properties and cortical formation.	BCL11B CEP164	5.26e-04	25	47	2	32238932
Pubmed	Relief of hypoxia by angiogenesis promotes neural stem cell differentiation by targeting glycolysis.	BCL11B HEY1	5.69e-04	26	47	2	26856890
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	MAP3K20 BLM PCYT1A STRN3 PARN	5.77e-04	503	47	5	16964243
Pubmed	Robo1 modulates proliferation and neurogenesis in the developing neocortex.	BCL11B HEY1	6.14e-04	27	47	2	24741061
Pubmed	Autism candidate gene DIP2A regulates spine morphogenesis via acetylation of cortactin.	SYN1 BCL11B	6.61e-04	28	47	2	31600191
Pubmed	Genomic architecture of Shh-dependent cochlear morphogenesis.	HEY1 GAS2	6.61e-04	28	47	2	31488567
Pubmed	Endosomal Rab cycles regulate Parkin-mediated mitophagy.	GDI1 GDI2	6.61e-04	28	47	2	29360040
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	PCYT1A STRN3 CTH GNE GDI1 GDI2 CSNK2A2 HPRT1	6.75e-04	1455	47	8	22863883
Pubmed	Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells.	HEY1 HPRT1	7.09e-04	29	47	2	25535917
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	SMARCA1 DACH1 PHIP NDUFS2 CSNK2A2	7.49e-04	533	47	5	30554943
Pubmed	Genome-wide characterisation of Foxa1 binding sites reveals several mechanisms for regulating neuronal differentiation in midbrain dopamine cells.	SMARCA1 HEY1	7.59e-04	30	47	2	25804738
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	PCYT1A STRN3 LUC7L3 GDI1 GDI2 CSNK2A2 HPRT1	8.36e-04	1149	47	7	35446349
Pubmed	A pancreatic cancer-specific expression profile.	SLC12A2 NDUFS2	8.64e-04	32	47	2	8895530
Pubmed	The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3.	SYN1 GDI1 GDI2 NDUFS2 HPRT1	8.76e-04	552	47	5	36293380
Pubmed	Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.	SYN1 SLC12A2 GDI1 GDI2 HPRT1	9.19e-04	558	47	5	35063084
Pubmed	Permissive ureter specification by TBX18-mediated repression of metanephric gene expression.	DACH1 HPRT1	1.09e-03	36	47	2	36960826
Pubmed	The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.	SMARCA1 BCL11B PHIP CSNK2A2	1.27e-03	349	47	4	25665578
Pubmed	MTG8 interacts with LHX6 to specify cortical interneuron subtype identity.	BCL11B HEY1	1.28e-03	39	47	2	36064547
Pubmed	A novel lncRNA MDHDH suppresses glioblastoma multiforme by acting as a scaffold for MDH2 and PSMA1 to regulate NAD+ metabolism and autophagy.	GDI1 GDI2	1.35e-03	40	47	2	36527092
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	BCL11B ZNF366 ZNF862 CASZ1 ZNF710 ZBTB43 ZNF513 ZNF114	6.75e-06	718	27	8	28
GeneFamily	WD repeat domain containing	WDR19 STRN3 PHIP	6.80e-03	262	27	3	362
Coexpression	GUO_TARGETS_OF_IRS1_AND_IRS2	HMGCR PCBP4 GNE PPM1A	2.78e-05	97	47	4	MM1318
Coexpression	GUO_TARGETS_OF_IRS1_AND_IRS2	HMGCR PCBP4 GNE PPM1A	2.78e-05	97	47	4	M2434
Coexpression	GSE40655_FOXO1_KO_VS_WT_NTREG_DN	WDR19 SYN1 NDUFS2 PIN4 GAS2	2.91e-05	200	47	5	M9441
Coexpression	GSE21546_SAP1A_KO_VS_SAP1A_KO_AND_ELK1_KO_ANTI_CD3_STIM_DP_THYMOCYTES_UP	BLM CTH SLC12A2 PIN4 ZBTB43	2.91e-05	200	47	5	M7525
ToppCell	Dendritic_Cells-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	SYN1 BCL11B AZIN2 ZNF366 CEP164	5.45e-07	151	47	5	e089bf197ed60e7243160521d4390d4b40a3832b
ToppCell	H1299-infected-SARSCoV2\|infected / Cell line, Condition and Strain	LUC7L3 GDI1 PHIP CEP164 PIN4	2.02e-06	197	47	5	0fa3e4cf93e77d78b1f97b906c5b13ca741ae17e
ToppCell	droplet-Liver-Hepatocytes-24m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYN1 PAPOLB SLC12A2 ZNF710	2.26e-05	157	47	4	ec433d2fe827abdb647be4176c231b7052482b6f
ToppCell	Leuk-UTI-Myeloid-tDC\|Leuk-UTI / Disease, Lineage and Cell Type	DACH1 SYN1 GAS2L3 FAM83F	2.50e-05	161	47	4	51b9f60986ed2e8e2297d31c80462c3ab65a2e5e
ToppCell	5'-Adult-Distal_Rectal-Epithelial-goblet-Goblet_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SLC12A2 GNE FAM83F ZNF710	3.62e-05	177	47	4	e1e45956887371b1c18f1eb479dd930031497520
ToppCell	ICU-NoSEP-Myeloid-tDC\|ICU-NoSEP / Disease, Lineage and Cell Type	CTH SLC12A2 GAS2L3 ZNF862	3.86e-05	180	47	4	be665e801512f6aaf6b3ecb26153bbdeb24619ac
ToppCell	Mesenchymal_cells-Chondrocytes\|Mesenchymal_cells / Lineage and Cell class	BLM CTH HMGCR GAS2L3	3.86e-05	180	47	4	6e399368430ef3afa9ce1ef0ed90f614ccef9987
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DACH1 CTH SLC12A2 ZNF366	4.58e-05	188	47	4	789d1be574e693d7bdd488f3c72c6df788e47b47
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DACH1 CTH SLC12A2 ZNF366	4.77e-05	190	47	4	a3c6eec6df052105ab78b7e3c78f94218d5912eb
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DACH1 CTH SLC12A2 ZNF366	4.97e-05	192	47	4	c07d7b40b2aa4eb27ac85801c014a656e2fd01dc
ToppCell	LPS-IL1RA+antiTNF-Endothelial\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DACH1 CTH SLC12A2 ZNF366	4.97e-05	192	47	4	04f5a2e3dd6beff027b89d66eefdd92036e041af
ToppCell	LPS-antiTNF-Endothelial-Endothelial\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DACH1 CTH SLC12A2 ZNF366	5.07e-05	193	47	4	02f633b016ab19bfa65bfd0cf32f000549a62148
ToppCell	LPS-antiTNF-Endothelial\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DACH1 CTH SLC12A2 ZNF366	5.07e-05	193	47	4	5122b1ffba42de190061be34ecdc6176f84e56a3
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Goblet\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	KRT23 GNE FAM83F HEY1	5.17e-05	194	47	4	e0228f593c3493175962a4817500d4337ddc4e88
ToppCell	Tracheal-10x5prime-Immune_Myeloid-Macrophage_alveolar-Macro_alv_dividing\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	BLM DACH1 NALCN ZNF114	5.27e-05	195	47	4	c96755d2eb98112b703b5dbee9c88730ace7dcbf
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Neuronal-ventral_progenitors_and_neurons_2\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	SYN1 BCL11B PCBP4 GDI1	5.60e-05	198	47	4	b73b9feb82997b654718aa27f33ca7b454214802
ToppCell	Sepsis-ICU-NoSEP-Myeloid-tDC\|ICU-NoSEP / Disease, condition lineage and cell class	CTH SLC12A2 GAS2L3 ZNF862	5.71e-05	199	47	4	90ddd686b8f39c6f6134b9b048396cebcf8d0448
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	DACH1 CTH SLC12A2 ZNF366	5.82e-05	200	47	4	a1fa6bae5a688faf488d6925cd3fad725dfa916b
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	DACH1 CTH SLC12A2 ZNF366	5.82e-05	200	47	4	89a6da2bdedc6b1ad0675c8753bf2b763a99af6a
ToppCell	LPS_anti-TNF-Endothelial\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	DACH1 CTH SLC12A2 ZNF366	5.82e-05	200	47	4	1d105eeda5a2c51f9a4654ffc79b7e2348ad593b
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10\|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.	DACH1 BCL11B HEY1 PHIP	5.82e-05	200	47	4	7c495030e6566b81d97b5516d1972e335ce5ed8c
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	DACH1 CTH SLC12A2 ZNF366	5.82e-05	200	47	4	58a7ece7dfdf6c46f2a50cbcb580574dec14c748
ToppCell	LPS_IL1RA_TNF-Endothelial\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	DACH1 CTH SLC12A2 ZNF366	5.82e-05	200	47	4	d01cec331be3b03cef80e9536fc531285bcf00f6
ToppCell	LPS_anti-TNF-Endothelial-Endothelial\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	DACH1 CTH SLC12A2 ZNF366	5.82e-05	200	47	4	60d2cbf41f37f1b11eddb4c9d9246c9c1fc5a5af
ToppCell	LPS_only-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS_only / Treatment groups by lineage, cell group, cell type	DACH1 CTH SLC12A2 ZNF366	5.82e-05	200	47	4	b1fadb2b5e37e0f51e079d8409c2647eef68dc3b
Drug	Biperiden hydrochloride [1235-82-1]; Down 200; 11.4uM; MCF7; HT_HG-U133A	MAP3K20 CTH BCL11B CEP164 PPM1A PIN4	2.84e-06	194	47	6	3321_DN
Drug	Dapsone [80-08-0]; Down 200; 16.2uM; PC3; HT_HG-U133A	PCYT1A MED18 ZNF862 CASZ1 PIN4 ZBTB43	2.93e-06	195	47	6	5078_DN
Drug	Methacholine chloride [62-51-1]; Up 200; 20.4uM; MCF7; HT_HG-U133A	MED18 GNE ZNF862 CEP164 PIN4 ZBTB43	2.93e-06	195	47	6	3452_UP
Drug	N3-IQ	PCYT1A PHIP HPRT1	2.33e-05	27	47	3	CID000053462
Drug	TDP-4-keto-6-deoxy-D-glucose	WDR19 GNE	2.50e-05	4	47	2	CID000000685
Drug	5'-TT-3	PCYT1A HPRT1	4.15e-05	5	47	2	CID000482134
Drug	tetrachloroplatinum	DACH1 HPRT1	4.15e-05	5	47	2	CID000026031
Drug	Ccris 5336	PCYT1A HPRT1	4.15e-05	5	47	2	CID000107871
Drug	benzo(c)phenanthrene	BLM PHIP HPRT1	4.31e-05	33	47	3	CID000009136
Drug	Dipyridamole [58-32-2]; Down 200; 8uM; MCF7; HT_HG-U133A	MAP3K20 MED18 PPM1A PIN4 ZBTB43	4.66e-05	192	47	5	1517_DN
Drug	Tetrahydroalstonine [6474-90-4]; Up 200; 11.4uM; MCF7; HT_HG-U133A	MAP3K20 PCYT1A LUC7L3 FGD6 ZBTB43	4.77e-05	193	47	5	6209_UP
Drug	Spiramycin [8025-81-8]; Down 200; 4.8uM; PC3; HT_HG-U133A	MAP3K20 MED18 STRN3 BCL11B ZBTB43	4.89e-05	194	47	5	4319_DN
Drug	Apomorphine hydrochloride hemihydrate [41372-20-7]; Down 200; 6.4uM; MCF7; HT_HG-U133A	MAP3K20 DACH1 MED18 STRN3 PPM1A	5.01e-05	195	47	5	1505_DN
Drug	Dimaprit dihydrochloride [23256-33-9]; Down 200; 17uM; MCF7; HT_HG-U133A	STRN3 CTH BCL11B CEP164 ZNF710	5.01e-05	195	47	5	7480_DN
Drug	Mesoridazine besylate [32672-69-8]; Down 200; 7.4uM; MCF7; HT_HG-U133A	WDR19 MED18 STRN3 CASZ1 ZNF710	5.14e-05	196	47	5	7017_DN
Drug	2-propylpentanoic acid; Up 200; 200uM; MCF7; HT_HG-U133A	BCL11B ZNF862 CEP164 CASZ1 ZBTB43	5.14e-05	196	47	5	1639_UP
Drug	poly(dG-dC).poly(dG-dC	DACH1 PCYT1A PHIP	5.15e-05	35	47	3	CID000065376
Drug	Bendroflumethiazide [73-48-3]; Down 200; 9.4uM; MCF7; HT_HG-U133A	MED18 CTH BCL11B FGD6 ZNF710	5.26e-05	197	47	5	3415_DN
Drug	Norgestrel-(-)-D [797-63-7]; Down 200; 12.8uM; MCF7; HT_HG-U133A	MED18 FGD6 CASZ1 PIN4 ZBTB43	5.26e-05	197	47	5	3406_DN
Drug	Norfloxacin [70458-96-7]; Up 200; 12.6uM; PC3; HT_HG-U133A	MED18 STRN3 CEP164 ZNF710 ZBTB43	5.39e-05	198	47	5	2090_UP
Drug	Ajmalicine hydrochloride [4373-34-6]; Down 200; 10.2uM; MCF7; HT_HG-U133A	MAP3K20 MED18 STRN3 ZNF862 PIN4	5.39e-05	198	47	5	2898_DN
Drug	Levonordefrin [829-74-3]; Up 200; 21.8uM; MCF7; HT_HG-U133A	DACH1 MED18 GNE CEP164 ZBTB43	5.39e-05	198	47	5	3450_UP
Drug	16, 16-dimethylprostaglandin E2 methyl acetate solution; Down 200; 10uM; PC3; HT_HG-U133A	MAP3K20 MED18 BCL11B ZNF862 PIN4	5.39e-05	198	47	5	6592_DN
Drug	ionomycin calcium salt; Down 200; 2uM; MCF7; HT_HG-U133A_EA	WDR19 MAP3K20 BCL11B PCBP4 PPM1A	5.39e-05	198	47	5	871_DN
Drug	Glimepiride [93479-97-1]; Down 200; 8.2uM; MCF7; HT_HG-U133A	MED18 BCL11B PCBP4 ZNF710 ZBTB43	5.39e-05	198	47	5	2809_DN
Drug	Decamethonium bromide [541-22-0]; Up 200; 9.6uM; MCF7; HT_HG-U133A	SMARCA1 PCYT1A BCL11B GNE ZNF710	5.39e-05	198	47	5	7353_UP
Drug	Kaempferol [520-18-3]; Up 200; 14uM; PC3; HT_HG-U133A	FAM50B DACH1 STRN3 CEP164 ZNF710	5.52e-05	199	47	5	5839_UP
Drug	TNO-6	DACH1 HPRT1	6.22e-05	6	47	2	CID000071993
Drug	NSC82626	DACH1 CTH PHIP HPRT1	7.56e-05	109	47	4	CID000000645
Disease	Renal dysplasia and retinal aplasia (disorder)	WDR19 CEP164	1.49e-04	12	45	2	C0403553
Disease	Antihypertensive use measurement	DACH1 MED18 PHIP CASZ1	7.09e-04	265	45	4	EFO_0009927

Protein segments in the cluster

Peptide	Gene	Start	Entry
TVVGMSQMDSHKRKH	CASZ1	1581	Q86V15
EMGTELGHKMHVLDL	AZIN2	221	Q96A70
TLHVRMEKHFKNGMA	CTH	261	P32929
GHDMGHESKRMHIEK	DACH1	561	Q9UI36
KHMAAGVRMECHSKG	ASTN1	931	O14525
GKLVIGHNMLLDVMH	PARN	281	O95453
GMKITAMHLRRKELH	PAPOLB	481	Q9NRJ5
RMLMHGKEVGSIIGK	PCBP4	21	P57723
GIMSVNGKKVLHMDR	GDI2	21	P50395
MLGHHAEMEIARLLK	LMOD3	351	Q0VAK6
VKMIMSLGLVLVHAH	HMGCR	256	P04035
EGALKHMLKEGKGRM	PCYT1A	296	P49585
RHILCEKHGKIMEAM	PIN4	41	Q9Y237
VEGMRKELILMKKHH	KRT23	196	Q9C075
HLMGKQHMGYAKIKA	LUC7L3	211	O95232
HLAGLDKMSKGHMLA	NDUFS2	431	O75306
RDVMKEMGGHHIVAL	HPRT1	51	P00492
AKGHLFRKGIMKIMV	MED18	131	Q9BUE0
HMNKGMGHKFLKHIE	GTPBP10	211	A4D1E9
KRHMKTHMHKAGSLA	BCL11B	471	Q9C0K0
LKRLIMMEKDGNHHT	BLM	1001	P54132
MVRVMRKKGIEHHPN	GNE	261	Q9Y223
DKILFIRMLHGKHVM	GAS2L3	246	Q86XJ1
IRMLHGKHVMVRVGG	GAS2L3	251	Q86XJ1
KGIMHRDVKPHNVMI	CSNK2A2	151	P19784
KGMHYLHMEAPVKVI	MAP3K20	116	Q9NYL2
MTVDHLKMLHTAGGK	HEY1	96	Q9Y5J3
GIMSVNGKKVLHMDR	GDI1	21	P31150
RMLHNKHVMVRVGGG	GAS2	241	O43903
VVVKMGHAHSGMGKV	SYN1	266	P17600
KTGKMIHSMVAHLDA	STRN3	711	Q13033
AKEEMLQMIRHGATH	SMARCA1	661	P28370
KIHVKNGDHMKGARM	WDR19	1161	Q8NEZ3
GRMVSHMHRDLKPKS	FAM83F	401	Q8NEG4
HLDEMKSAMRKGHNL	CEP164	1171	Q9UPV0
MKHHLVGHMKIHTGI	ZBTB43	411	O43298
SMNLKRHMLRHTGEK	ZNF513	456	Q8N8E2
QHMKMHKRILGHLSS	PHIP	171	Q8WWQ0
HMRVMSEKKHGADRS	PPM1A	111	P35813
GHVHMGPRRQAMKEM	SLC12A2	821	P55011
NGMKSKVHHIAKEIM	FGD6	866	Q6ZV73
SRHMKVKHGVMDIGL	ZNF710	591	Q8N1W2
IGHRAKGMLKLMRGF	ZNF862	821	O60290
GNLTRHMKVKHGVME	ZNF366	546	Q8N895
HMKVKHGVMERGLHS	ZNF366	551	Q8N895
KVEEEMKKHGSTHMG	POTEH	451	Q6S545
QSFLMRHMKIHTGEK	ZNF114	316	Q8NC26
GTMREAGRAMHLLKK	FAM50B	6	Q9Y247
MIAKMHIRGIVKGDS	NALCN	86	Q8IZF0