Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	5-methylcytosine dioxygenase activity	TET2 TET3	2.07e-05	3	53	2	GO:0070579
Domain	BAT2_N	PRRC2C PRRC2A PRRC2B	1.92e-08	3	51	3	PF07001
Domain	BAT2_N	PRRC2C PRRC2A PRRC2B	1.92e-08	3	51	3	IPR009738
Domain	PRRC2	PRRC2C PRRC2A PRRC2B	1.92e-08	3	51	3	IPR033184
Pubmed	TET2 and TET3 loss disrupts small intestine differentiation and homeostasis.	TET2 TET3	2.28e-06	2	53	2	37414790
Pubmed	TET enzymes control antibody production and shape the mutational landscape in germinal centre B cells.	TET2 TET3	2.28e-06	2	53	2	31120187
Pubmed	Genome-wide association study of bipolar disorder in Canadian and UK populations corroborates disease loci including SYNE1 and CSMD1.	SYNE1 CSMD1	2.28e-06	2	53	2	24387768
Pubmed	Role of Chromatin Remodeling Genes and TETs in the Development of Human Midbrain Dopaminergic Neurons.	TET2 TET3	2.28e-06	2	53	2	32367481
Pubmed	Molecular pathogenesis of progression to myeloid leukemia from TET-insufficient status.	TET2 TET3	2.28e-06	2	53	2	32126143
Pubmed	Distinct roles for TET family proteins in regulating human erythropoiesis.	TET2 TET3	2.28e-06	2	53	2	28167661
Pubmed	Acute loss of TET function results in aggressive myeloid cancer in mice.	TET2 TET3	2.28e-06	2	53	2	26607761
Pubmed	TET2 and CSMD1 genes affect SBP response to hydrochlorothiazide in never-treated essential hypertensives.	TET2 CSMD1	2.28e-06	2	53	2	25695618
Pubmed	Epigenetic silencing of TET2 and TET3 induces an EMT-like process in melanoma.	TET2 TET3	2.28e-06	2	53	2	27852070
Pubmed	Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency by complementary mechanisms.	TET2 TET3	2.28e-06	2	53	2	27729528
Pubmed	TET proteins regulate Drosha expression and impact microRNAs in iNKT cells.	TET2 TET3	2.28e-06	2	53	2	39364402
Pubmed	Ten-eleven translocation (Tet) methylcytosine dioxygenase-dependent viral DNA demethylation mediates in vivo hepatitis B virus (HBV) biosynthesis.	TET2 TET3	2.28e-06	2	53	2	38179947
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PLEKHM2 PRRC2C SYNE1 SIPA1L1 ST18 TET3 PRRC2B	2.77e-06	407	53	7	12693553
Pubmed	PRRC2B modulates oligodendrocyte progenitor cell development and myelination by stabilizing Sox2 mRNA.	PRRC2C PRRC2A PRRC2B	5.04e-06	22	53	3	38507412
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	TET2 NEK1 ARHGEF28 FAM13A PRRC2C SIPA1L1 AKAP11 RAB11FIP1 KIF13A	5.60e-06	861	53	9	36931259
Pubmed	Reelin influences the expression and function of dopamine D2 and serotonin 5-HT2A receptors: a comparative study.	RELN HTR2A	6.83e-06	3	53	2	25637489
Pubmed	Expression of TET and 5-HmC in Trophoblast Villi of Women with Normal Pregnancy and with Early Pregnancy Loss.	TET2 TET3	6.83e-06	3	53	2	30074219
Pubmed	Induced DNA demethylation by targeting Ten-Eleven Translocation 2 to the human ICAM-1 promoter.	TET2 TET3	6.83e-06	3	53	2	24194590
Pubmed	TET proteins in malignant hematopoiesis.	TET2 TET3	6.83e-06	3	53	2	19923888
Pubmed	5-Hydroxymethylcytosine-mediated active demethylation is required for mammalian neuronal differentiation and function.	TET2 TET3	6.83e-06	3	53	2	34919053
Pubmed	Distinct and overlapping control of 5-methylcytosine and 5-hydroxymethylcytosine by the TET proteins in human cancer cells.	TET2 TET3	6.83e-06	3	53	2	24958354
Pubmed	Selective targeting of TET catalytic domain promotes somatic cell reprogramming.	TET2 TET3	6.83e-06	3	53	2	32024762
Pubmed	Tet Enzymes Regulate Telomere Maintenance and Chromosomal Stability of Mouse ESCs.	TET2 TET3	6.83e-06	3	53	2	27184841
Pubmed	One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering.	TET2 TET3	6.83e-06	3	53	2	23643243
Pubmed	Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine.	TET2 TET3	6.83e-06	3	53	2	21778364
Pubmed	Tissue-specific DNA demethylation is required for proper B-cell differentiation and function.	TET2 TET3	6.83e-06	3	53	2	27091986
Pubmed	Stage-specific regulation of DNA methylation by TET enzymes during human cardiac differentiation.	TET2 TET3	6.83e-06	3	53	2	34879277
Pubmed	Tet family proteins and 5-hydroxymethylcytosine in development and disease.	TET2 TET3	6.83e-06	3	53	2	22569552
Pubmed	Oxygen regulation of TET enzymes.	TET2 TET3	6.83e-06	3	53	2	33410283
Pubmed	Postnatal DNA demethylation and its role in tissue maturation.	TET2 TET3	6.83e-06	3	53	2	29795194
Pubmed	Effect of aging on 5-hydroxymethylcytosine in brain mitochondria.	TET2 TET3	6.83e-06	3	53	2	22445327
Pubmed	Control of Foxp3 stability through modulation of TET activity.	TET2 TET3	6.83e-06	3	53	2	26903244
Pubmed	Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1.	TET2 TET3	6.83e-06	3	53	2	19372391
Pubmed	Loss of Tet enzymes compromises proper differentiation of embryonic stem cells.	TET2 TET3	6.83e-06	3	53	2	24735881
Pubmed	Hyperglycemia affects global 5-methylcytosine and 5-hydroxymethylcytosine in blood genomic DNA through upregulation of SIRT6 and TETs.	TET2 TET3	6.83e-06	3	53	2	30987683
Pubmed	Primary role of the serotonergic midline system in synchronized spontaneous activity during development of the embryonic mouse hindbrain.	ARHGEF28 HTR2A	6.83e-06	3	53	2	16902991
Pubmed	Differential expression of ten-eleven translocation genes in endometrial cancers.	TET2 TET3	6.83e-06	3	53	2	28349832
Pubmed	Improvement of Foxp3 stability through CNS2 demethylation by TET enzyme induction and activation.	TET2 TET3	6.83e-06	3	53	2	29048538
Pubmed	Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification.	TET2 TET3	6.83e-06	3	53	2	20639862
Pubmed	Ten-Eleven Translocation Genes are Downregulated in Endometriosis.	TET2 TET3	6.83e-06	3	53	2	26917261
Pubmed	Iron-dependent epigenetic modulation promotes pathogenic T cell differentiation in lupus.	TET2 TET3	6.83e-06	3	53	2	35499082
Pubmed	Mechanisms of TET protein-mediated DNA demethylation and its role in the regulation of mouse development.	TET2 TET3	6.83e-06	3	53	2	25608811
Pubmed	TET proteins regulate the lineage specification and TCR-mediated expansion of iNKT cells.	TET2 TET3	6.83e-06	3	53	2	27869820
Pubmed	TET2 promotes histone O-GlcNAcylation during gene transcription.	TET2 TET3	6.83e-06	3	53	2	23222540
Pubmed	Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies.	TET2 TET3	6.83e-06	3	53	2	19420352
Pubmed	Alternation of ten-eleven translocation 1, 2, and 3 expression in eutopic endometrium of women with endometriosis-associated infertility.	TET2 TET3	6.83e-06	3	53	2	30130982
Pubmed	Overexpression of TET dioxygenases in seminomas associates with low levels of DNA methylation and hydroxymethylation.	TET2 TET3	6.83e-06	3	53	2	28218476
Pubmed	Ascorbate induces ten-eleven translocation (Tet) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine.	TET2 TET3	6.83e-06	3	53	2	23548903
Pubmed	Regulation of DNA methylation signatures on NF-κB and STAT3 pathway genes and TET activity in cigarette smoke extract-challenged cells/COPD exacerbation model in vitro.	TET2 TET3	6.83e-06	3	53	2	32342329
Pubmed	Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta.	SIPA1L1 AKAP11 TET3 PRRC2B	1.11e-05	90	53	4	15033168
Pubmed	TET1 Directs Chondrogenic Differentiation by Regulating SOX9 Dependent Activation of Col2a1 and Acan In Vitro.	TET2 TET3	1.36e-05	4	53	2	33134768
Pubmed	Tet-mediated DNA demethylation regulates specification of hematopoietic stem and progenitor cells during mammalian embryogenesis.	TET2 TET3	1.36e-05	4	53	2	35235365
Pubmed	Loss of TET proteins in regulatory T cells promotes abnormal proliferation, Foxp3 destabilization and IL-17 expression.	TET2 TET3	1.36e-05	4	53	2	30726915
Pubmed	Phosphorylation of TET proteins is regulated via O-GlcNAcylation by the O-linked N-acetylglucosamine transferase (OGT).	TET2 TET3	1.36e-05	4	53	2	25568311
Pubmed	Tet inactivation disrupts YY1 binding and long-range chromatin interactions during embryonic heart development.	TET2 TET3	1.36e-05	4	53	2	31541101
Pubmed	Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine.	TET2 TET3	1.36e-05	4	53	2	21321204
Pubmed	Paradoxical association of TET loss of function with genome-wide DNA hypomethylation.	TET2 TET3	1.36e-05	4	53	2	31371502
Pubmed	Differential regulation of the ten-eleven translocation (TET) family of dioxygenases by O-linked β-N-acetylglucosamine transferase (OGT).	TET2 TET3	1.36e-05	4	53	2	24394411
Pubmed	Tet2 and Tet3 cooperate with B-lineage transcription factors to regulate DNA modification and chromatin accessibility.	TET2 TET3	1.36e-05	4	53	2	27869616
Pubmed	Activation-induced cytidine deaminase alters the subcellular localization of Tet family proteins.	TET2 TET3	1.36e-05	4	53	2	23028748
Pubmed	Deterministic Somatic Cell Reprogramming Involves Continuous Transcriptional Changes Governed by Myc and Epigenetic-Driven Modules.	TET2 TET3	1.36e-05	4	53	2	30554962
Pubmed	TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS.	TET2 TET3	1.36e-05	4	53	2	23353889
Pubmed	The intrinsic and extrinsic effects of TET proteins during gastrulation.	TET2 TET3	1.36e-05	4	53	2	35908548
Pubmed	CD4 expression in effector T cells depends on DNA demethylation over a developmentally established stimulus-responsive element.	TET2 TET3	2.27e-05	5	53	2	35304452
Pubmed	Loss of TET2 and TET3 in regulatory T cells unleashes effector function.	TET2 TET3	2.27e-05	5	53	2	31043609
Pubmed	DNA demethylation fine-tunes IL-2 production during thymic regulatory T cell differentiation.	TET2 TET3	2.27e-05	5	53	2	36880575
Pubmed	TET is targeted for proteasomal degradation by the PHD-pVHL pathway to reduce DNA hydroxymethylation.	TET2 TET3	2.27e-05	5	53	2	32963106
Pubmed	Lineage-specific functions of TET1 in the postimplantation mouse embryo.	TET2 TET3	2.27e-05	5	53	2	28504700
Pubmed	Loss of adipose TET proteins enhances β-adrenergic responses and protects against obesity by epigenetic regulation of β3-AR expression.	TET2 TET3	2.27e-05	5	53	2	35737830
Pubmed	Dynamic expression of TET1, TET2, and TET3 dioxygenases in mouse and human placentas throughout gestation.	TET2 TET3	2.27e-05	5	53	2	29108636
Pubmed	CRL4(VprBP) E3 ligase promotes monoubiquitylation and chromatin binding of TET dioxygenases.	TET2 TET3	2.27e-05	5	53	2	25557551
Pubmed	Frequent somatic mutations in epigenetic regulators in newly diagnosed chronic myeloid leukemia.	TET2 TET3	2.27e-05	5	53	2	28452984
Pubmed	TET-Mediated Sequestration of miR-26 Drives EZH2 Expression and Gastric Carcinogenesis.	TET2 TET3	2.27e-05	5	53	2	28923852
Pubmed	Ten-eleven translocation (Tet) and thymine DNA glycosylase (TDG), components of the demethylation pathway, are direct targets of miRNA-29a.	TET2 TET3	2.27e-05	5	53	2	23820384
Pubmed	TET1 contributes to neurogenesis onset time during fetal brain development in mice.	TET2 TET3	3.40e-05	6	53	2	26902115
Pubmed	Maternal high-fat diet alters Tet-mediated epigenetic regulation during heart development.	TET2 TET3	3.40e-05	6	53	2	39262804
Pubmed	Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity.	TET2 TET3	3.40e-05	6	53	2	32572241
Pubmed	TET enzymes augment activation-induced deaminase (AID) expression via 5-hydroxymethylcytosine modifications at the Aicda superenhancer.	TET2 TET3	4.76e-05	7	53	2	31028100
Pubmed	Osteoclasts adapt to physioxia perturbation through DNA demethylation.	TET2 TET3	4.76e-05	7	53	2	34661337
Pubmed	Downregulation of ten-eleven translocation-2 triggers epithelial differentiation during organogenesis.	TET2 TET3	6.34e-05	8	53	2	35569195
Pubmed	Spurious transcription causing innate immune responses is prevented by 5-hydroxymethylcytosine.	TET2 TET3	6.34e-05	8	53	2	36539616
Pubmed	DNA methyltransferase 3b regulates articular cartilage homeostasis by altering metabolism.	TET2 TET3	6.34e-05	8	53	2	28614801
Pubmed	Diverse alternative back-splicing and alternative splicing landscape of circular RNAs.	ASPH PRRC2B	6.34e-05	8	53	2	27365365
Pubmed	Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population.	HTR2A KIF13A STK24	7.00e-05	52	53	3	19328558
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	TNRC18 FAM13A PCNX4 KIZ ASPH APBB2 CSMD1 ZNF839 TET3 ZNF248	7.28e-05	1489	53	10	28611215
Pubmed	Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.	PRRC2C CSMD1 ST18	7.42e-05	53	53	3	23535033
Pubmed	Analysis of HIV-1 Gag protein interactions via biotin ligase tagging.	PRRC2C RBM26 PRRC2A	7.84e-05	54	53	3	25631074
Pubmed	TET1 regulates fibroblast growth factor 8 transcription in gonadotropin releasing hormone neurons.	TET2 TET3	8.15e-05	9	53	2	31361780
Pubmed	Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development.	RELN APBB2	1.02e-04	10	53	2	16407979
Pubmed	Dysregulation of the TET family of epigenetic regulators in lymphoid and myeloid malignancies.	TET2 TET3	1.02e-04	10	53	2	31467060
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	SMARCA5 FAM13A RBM26 RAB11FIP1 KIF13A PRRC2A	1.15e-04	503	53	6	16964243
Pubmed	The centrosomal deubiquitylase USP21 regulates Gli1 transcriptional activity and stability.	SLF1 SYNE1	1.24e-04	11	53	2	27621083
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	TET2 RELN SYNE1 SIPA1L1 CNTNAP1 APBB2 SENP6 ST18 PRRC2A	1.28e-04	1285	53	9	35914814
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	TET2 PHF20 SIPA1L1 CLPTM1 PRRC2A STK24	1.62e-04	536	53	6	15840001
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	TET2 PHF20 SIPA1L1 CLPTM1 PRRC2A STK24	1.65e-04	538	53	6	10512203
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	SMARCA5 FAM13A WDHD1 SIPA1L1 ASPH SENP6 PRRC2A	1.67e-04	774	53	7	15302935
Pubmed	Proximity labelling identifies pro-migratory endocytic recycling cargo and machinery of the Rab4 and Rab11 families.	ARHGDIB SYNE1 APBB2 RAB11FIP1 STK24	1.67e-04	339	53	5	37232246
Pubmed	A mutation in the tuft mouse disrupts TET1 activity and alters the expression of genes that are crucial for neural tube closure.	TET2 TET3	1.76e-04	13	53	2	26989192
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	NEK1 SMARCA5 PRRC2C RBM26 PRRC2A PRRC2B	1.84e-04	549	53	6	38280479
Pubmed	Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease.	FAM13A CSMD1	2.05e-04	14	53	2	25241909
Cytoband	4q22.1	FAM13A HSP90AB3P	4.18e-04	26	53	2	4q22.1
Cytoband	Ensembl 112 genes in cytogenetic band chr4q22	FAM13A HSP90AB3P	3.35e-03	74	53	2	chr4q22
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	NEK1 SMARCA5 PHF20 WDHD1 PRRC2C DUSP1 SIPA1L1 APBB2 AKAP11 ATP13A3 STK24	9.20e-07	856	53	11	M4500
ToppCell	control-Neutrophil\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TET2 TNRC18 FAM13A DUSP1 RAB11FIP1 KIF13A	1.38e-07	200	53	6	b5d197472799cc61d7497faed91ac2564ae4930a
ToppCell	severe-HLA-DR+_CD83+_Monocyte\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TET2 DUSP1 ASPH ATP13A3 RAB11FIP1	3.79e-06	198	53	5	d5e525d2f2226d06a3fb985ce3a33555ff4b2e7b
ToppCell	COVID-19_Mild-Neu_3\|World / 5 Neutrophil clusters in COVID-19 patients	ARHGEF28 CNTNAP1 VWA3B CSMD1	1.36e-05	122	53	4	2aa9cfadab70312882ae679e3788fc7ab996c0f3
ToppCell	5'-Adult-SmallIntestine-Epithelial-Tuft-related-Tuft\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TET2 B4GALNT4 CSMD1 ST18	4.76e-05	168	53	4	8072d0496b7b730c4601009eaa69ec5366d26d73
ToppCell	facs-Heart-RA-18m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMARCA5 RBM26 SENP6 STK24	5.96e-05	178	53	4	b505e2550860e777535ee95f29c936242fd607f1
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN NRK CSMD1 ST18	6.78e-05	184	53	4	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN NRK CSMD1 ST18	6.78e-05	184	53	4	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN NRK CSMD1 ST18	6.78e-05	184	53	4	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.5.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TET2 SIPA1L1 ATP13A3 TET3	6.78e-05	184	53	4	d1ea2b60fb1ca1a0b809d131310c43903a9e84ce
ToppCell	COPD-Myeloid-cMonocyte\|World / Disease state, Lineage and Cell class	TET2 SIPA1L1 ATP13A3 CSMD1	6.78e-05	184	53	4	ceec41ed5636032aaf7716d1203816ea58bd39bd
ToppCell	pdx-Tumor_cells-T0\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	RELN ARHGEF28 APBB2 ST18	6.92e-05	185	53	4	1d874608aa2062024323512f68889219471b2f00
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARHGEF28 FAM13A ASPH RAB11FIP1	7.07e-05	186	53	4	4e94158db52df41d71e67b02b9895a358eebee0f
ToppCell	facs-Pancreas-Endocrine-24m\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN DUSP1 RBM26 PRRC2B	7.52e-05	189	53	4	010fdd70e9d0e21b856306a29ff877776a480319
ToppCell	COPD-Myeloid-cMonocyte\|COPD / Disease state, Lineage and Cell class	TET2 DUSP1 SIPA1L1 ATP13A3	7.52e-05	189	53	4	d29f3a0bd23e6eb46389e6eb7ef21851c7b57545
ToppCell	renal_cortex_nuclei-Adult_normal_reference\|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	PRRC2C DUSP1 IYD ST18	7.52e-05	189	53	4	a48df46274d51e84ffb40264646de7346104efb9
ToppCell	IPF-Myeloid-cMonocyte\|IPF / Disease state, Lineage and Cell class	TET2 DUSP1 SIPA1L1 ATP13A3	7.68e-05	190	53	4	a099f51f2b7618b6712af38eedd5ee64d8663a4a
ToppCell	Control-Myeloid-cDC2\|Control / Disease state, Lineage and Cell class	TET2 SIPA1L1 CSMD1 ST18	7.68e-05	190	53	4	4e481e42353d47af7991744000403af2873f6a41
ToppCell	Control-Myeloid-cDC2\|World / Disease state, Lineage and Cell class	TET2 SIPA1L1 CSMD1 ST18	7.83e-05	191	53	4	11dfd8f38beb294f42710cfbd355cb089e1023c0
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMARCA5 PRRC2C SENP6 AKAP11	7.83e-05	191	53	4	60c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCell	5'-Adult-LargeIntestine-Epithelial-Tuft-related-Tuft\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TET2 B4GALNT4 CSMD1 ST18	7.83e-05	191	53	4	54f07e4de61735051498846afb44b1798bed8144
ToppCell	COPD-Myeloid-cDC2\|World / Disease state, Lineage and Cell class	TET2 SIPA1L1 CSMD1 ST18	7.83e-05	191	53	4	4e4887175200a57e1b041f2f131e3df774df3509
ToppCell	facs-Pancreas-Endocrine-24m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN DUSP1 RBM26 PRRC2B	7.83e-05	191	53	4	a251b134f67a0a1ef3a42f50042f128a17f20b22
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMARCA5 PRRC2C SENP6 AKAP11	7.83e-05	191	53	4	09db184cb90fe282a14474d7217068c58092c6f8
ToppCell	COPD-Myeloid-cDC2\|COPD / Disease state, Lineage and Cell class	TET2 SIPA1L1 CSMD1 ST18	7.83e-05	191	53	4	2af6e4a6bd1f2193ece2131c3b7d976dd23a6966
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMARCA5 PRRC2C SENP6 AKAP11	7.83e-05	191	53	4	973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCell	COPD-Myeloid-cDC2\|Myeloid / Disease state, Lineage and Cell class	TET2 SIPA1L1 CSMD1 ST18	7.99e-05	192	53	4	984cdc2f1d93e164bc946d63f58dacb629f82eb7
ToppCell	367C-Myeloid-Monocyte-CD14+_Monocyte\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	TET2 DUSP1 SIPA1L1 ATP13A3	8.15e-05	193	53	4	c7ecd98729419b34c14f9b387b15472c47951d2f
ToppCell	nucseq-Immune-Immune_Myeloid-Myeloid_Dendritic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TET2 SIPA1L1 CSMD1 ST18	8.32e-05	194	53	4	bde6830a281f7cd7fd1733e40a41ddd2673ba88e
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SYT16 KIZ RAB11FIP1 STK24	8.32e-05	194	53	4	46070fbb0ee0eb9e1801c43b73a15707471056dc
ToppCell	droplet-Limb_Muscle-MUSCLE\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMARCA5 PRRC2C SENP6 TET3	8.32e-05	194	53	4	e3d63874111d1e8da3977329426e4dcf68d6de87
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SYT16 KIZ RAB11FIP1 STK24	8.32e-05	194	53	4	abacb6a8d7a9003f2f6c2be0305507f1c1c50347
ToppCell	Children_(3_yrs)-Immune-alveolar_macrophage_(MARCO_positive)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PLEKHM2 ATP13A3 ST18 TET3	8.49e-05	195	53	4	9d649ac7d2af313481069c95349efc0c68449e2b
ToppCell	COVID-19-Myeloid-Transitioning_MDM\|COVID-19 / group, cell type (main and fine annotations)	TET2 SIPA1L1 ATP13A3 ST18	8.65e-05	196	53	4	4929cfed1f150c1fde4d79cb49895c2ea467a18f
ToppCell	nucseq-Immune-Immune_Myeloid-Myeloid_Dendritic-cDC2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TET2 SIPA1L1 CSMD1 ST18	8.83e-05	197	53	4	a902aa05e5f711bcfdd9e19749ab636b597eb116
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SYT16 SLF1 SYNE1 CSMD1	9.00e-05	198	53	4	4ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RELN NRK CNTNAP1 APBB2	9.18e-05	199	53	4	83383d9ae4f501754fd3da0215ce6f0e3c70562c
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	SYT16 SLF1 SYNE1 CSMD1	9.36e-05	200	53	4	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	control-HLA-DR-_S100A+_Monocyte\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TET2 TNRC18 RAB11FIP1 KIF13A	9.36e-05	200	53	4	9e3e13a68bc1110fa000ec2d80f4c654ddbce17e
Drug	Levocabastine hydrochloride [79547-78-7]; Down 200; 8.8uM; HL60; HT_HG-U133A	NEK1 PHF20 WDHD1 SYNE1 COQ6 ASPH APBB2	3.48e-07	200	52	7	2948_DN
Drug	Fluocinonide [356-12-7]; Up 200; 8uM; PC3; HT_HG-U133A	ZNF280A HTR2A DUSP1 APBB2 KIF13A MMP17	5.36e-06	195	52	6	3757_UP
Disease	chronic obstructive pulmonary disease, chronic bronchitis	FAM13A CSMD1	1.41e-04	10	53	2	EFO_0000341, EFO_0006505
Disease	body fat percentage	SYT16 RELN FAM13A PRRC2A STK24 PRRC2B	2.36e-04	488	53	6	EFO_0007800
Disease	otosclerosis	RELN SIPA1L1 HSP90AB3P	4.23e-04	81	53	3	EFO_0004213
Disease	sucrose liking measurement	RELN CDH20	5.89e-04	20	53	2	EFO_0010157
Disease	cholangiocarcinoma (is_implicated_in)	WDHD1 ASPH	7.15e-04	22	53	2	DOID:4947 (is_implicated_in)
Disease	Involutional paraphrenia	RELN HTR2A	9.25e-04	25	53	2	C1571983
Disease	Psychosis, Involutional	RELN HTR2A	9.25e-04	25	53	2	C1571984
Disease	Involutional Depression	RELN HTR2A	9.25e-04	25	53	2	C0011574
Disease	cerebellum cortex volume change measurement, age at assessment	CSMD1 STK24	1.00e-03	26	53	2	EFO_0008007, EFO_0021497
Disease	alcohol consumption measurement	RELN PLEKHM2 SENP6 AKAP11 CSMD1 ST18 TET3 STK24	1.58e-03	1242	53	8	EFO_0007878
Disease	Chronic Obstructive Airway Disease	HTR2A FAM13A	1.61e-03	33	53	2	C0024117
Disease	Chronic Airflow Obstruction	HTR2A FAM13A	1.61e-03	33	53	2	C1527303
Disease	longevity	SYT16 FAM13A CSMD1 STK24	1.70e-03	284	53	4	EFO_0004300
Disease	Alzheimer disease	RELN PRRC2C CSMD1 ST18 STK24	1.76e-03	485	53	5	MONDO_0004975
Disease	bitter alcoholic beverage consumption measurement	RELN CSMD1 TET3	1.78e-03	133	53	3	EFO_0010092
Disease	pancreatitis (biomarker_via_orthology)	DUSP1 HSP90AB3P	2.25e-03	39	53	2	DOID:4989 (biomarker_via_orthology)
Disease	telomere length	SYT16 ARHGEF28 CSMD1 PRRC2A	2.42e-03	313	53	4	EFO_0004505
Disease	autism spectrum disorder (implicated_via_orthology)	ZNF280A HTR2A CNTNAP1	2.60e-03	152	53	3	DOID:0060041 (implicated_via_orthology)
Disease	Alcohol Use Disorder	HTR2A ST18	2.85e-03	44	53	2	C0001956
Disease	obsolete aging, epigenetic status	KIF13A ZNF248	3.11e-03	46	53	2	EFO_0000473, GO_0007568

Protein segments in the cluster

Peptide	Gene	Start	Entry
EFEKQRNDSWEDHTT	ZNF280A	321	P59817
SSFSDVAEEETWHQQ	ERICH3	1376	Q5RHP9
LTVHSDDFEFNDDEW	CNTNAP1	861	P78357
DETDIWSDHSFQTDP	APBB2	276	Q92870
SFATEQNWDSLEIHD	CSMD1	1846	Q96PZ7
FWNSSHVDNETELDE	ATP13A3	1051	Q9H7F0
EANTSDAFNWTVDSE	HTR2A	36	P28223
DAVNSAFWSDADHTD	COQ6	291	Q9Y2Z9
AFWSDADHTDFIDTA	COQ6	296	Q9Y2Z9
DSTGSWSNLSFEDEH	AKAP11	1731	Q9UKA4
WSNLSFEDEHQDESS	AKAP11	1736	Q9UKA4
DSFEHEVWQDASSFR	ASPH	721	Q12797
QWEDFSNSNSETEEE	DNHD1	2716	Q96M86
NTTESWSEFHEDQVD	RBM26	266	Q5T8P6
TDTLNFSFWSEQDEH	C9orf64	71	Q5T6V5
WSDLSSDAQEFEAES	ARHGEF28	816	Q8N1W1
DDNPSSESALNEEWH	NEK1	1151	Q96PY6
SESALNEEWHSDNSD	NEK1	1156	Q96PY6
TKHNDDEQYAWESSA	HSP90AB3P	126	Q58FF7
DSEQLDSGHEFEWED	BNIPL	131	Q7Z465
DSLNSETFNDWSDDN	PCNX4	811	Q63HM2
NALWDESDDSNSEIE	KIZ	641	Q2M2Z5
FSSWQRENSDSDEAH	FAM13A	581	O94988
TFDDEGTSHEENWSF	RELN	3061	P78509
DIWQDDSECSENHSF	GLP2R	151	O95838
SFFTDDDKQDHLSWE	ARHGDIB	176	P52566
EDNHKADISSWFNEA	DUSP1	226	P28562
ATSDSEQSFDFLTDW	CDH20	766	Q9HBT6
SQDTEFSWSDNERSS	FAM104B	36	Q5XKR9
HSEFSSTIATESQWD	SLC22A7	121	Q9Y694
QFCSSDWQEIHFDTE	MTBP	91	Q96DY7
SSDLHQAEEDADEWQ	IYD	51	Q6PHW0
DNLSESSSESFLWSD	PHF20	611	Q9BVI0
SFNSVTSTNLEWDDS	PLEKHM2	196	Q8IWE5
DDEVSATASWDSSVH	KIF13A	1221	Q9H1H9
QNWLAASESSSEEES	NRK	831	Q7Z2Y5
QWDEDDNEDESSSAS	RAB11FIP1	256	Q6WKZ4
WSQEDANSLFLEVDH	SYT16	76	Q17RD7
QQDLSSWSSADELDT	SYNE1	8666	Q8NF91
DTHFDDDEAWTFRSS	MMP17	221	Q9ULZ9
WKAEQSHDDSSSEDS	STK24	306	Q9Y6E0
QANEEWETASESSDF	PRRC2C	1491	Q9Y520
QANEEWETASESSDF	PRRC2A	1316	P48634
SSNASSAHSDEKWYD	SIPA1L1	1291	O43166
DNESNSESAENGWDS	ST18	191	O60284
ASDDNSEFWLSLDES	B4GALNT4	186	Q76KP1
TDFNATSALFWEQHD	CLPTM1	116	O96005
NQTWDEHEASSDFIS	TNRC18	1596	O15417
ESWSHQFDLSDNFIS	WDHD1	216	O75717
LSYQNSSDHANEEWE	PRRC2B	1361	Q5JSZ5
SSDHANEEWETASES	PRRC2B	1366	Q5JSZ5
KNNWSFDHEEESEGD	SENP6	31	Q9GZR1
EELWSDSEHNFLDEN	TET3	1636	O43151
SVWTEHSNEETNKDF	SLF1	211	Q9BQI6
NALEHSSDQDTWDSL	ZNF839	611	A8K0R7
YDHDSSDVSSENWLK	VWA3B	836	Q502W6
SADDFDSWFDTNNCL	SMARCA5	361	O60264
EDNDEVWSDSEQSFL	TET2	1841	Q6N021
SSQENEDDHFWELLF	ZNF248	91	Q8NDW4