Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ATP-dependent activity	MYO1E ATAD5 TMEM94 CFTR DNAH2 TOR1A MCM2 CHD1L FANCM DNAH1 ATP11B ACSBG2 KIF11	1.47e-05	614	102	13	GO:0140657
Domain	RBD	TIAM2 RGS14 TIAM1	5.13e-06	7	100	3	SM00455
Domain	RBD_dom	TIAM2 RGS14 TIAM1	5.13e-06	7	100	3	IPR003116
Domain	RBD	TIAM2 RGS14 TIAM1	5.13e-06	7	100	3	PS50898
Domain	Leu-rich_rpt_typical-subtyp	LRRC8E LRRC63 LGR5 ERBIN RSU1 LRR1 LRRC7	4.65e-05	177	100	7	IPR003591
Domain	LRR_TYP	LRRC8E LRRC63 LGR5 ERBIN RSU1 LRR1 LRRC7	4.65e-05	177	100	7	SM00369
Domain	K_chnl_volt-dep_ELK	KCNH8 KCNH4	8.48e-05	3	100	2	IPR003950
Domain	LRR	LRRC8E LRRC63 LGR5 ERBIN RSU1 LRR1 LRRC7	1.04e-04	201	100	7	PS51450
Domain	LRR_8	LRRC8E LRRC63 LGR5 ERBIN RSU1 LRRC7	3.16e-04	171	100	6	PF13855
Domain	-	LRRC8E LRRC63 LGR5 ERBIN RSU1 NLRC4 LRR1 LRRC7	3.30e-04	321	100	8	3.80.10.10
Domain	L_dom-like	LRRC8E LRRC63 LGR5 ERBIN RSU1 NLRC4 LRR1 LRRC7	3.81e-04	328	100	8	IPR032675
Domain	FAST_2	FASTKD1 FASTKD5	4.20e-04	6	100	2	PF08368
Domain	RAP	FASTKD1 FASTKD5	4.20e-04	6	100	2	SM00952
Domain	PH_BEACH	NBEAL1 LYST	4.20e-04	6	100	2	PF14844
Domain	FAST_Leu-rich	FASTKD1 FASTKD5	4.20e-04	6	100	2	IPR010622
Domain	RAP	FASTKD1 FASTKD5	4.20e-04	6	100	2	PF08373
Domain	RAP	FASTKD1 FASTKD5	4.20e-04	6	100	2	PS51286
Domain	FAST_1	FASTKD1 FASTKD5	4.20e-04	6	100	2	PF06743
Domain	RBD	RGS14 TIAM1	4.20e-04	6	100	2	PF02196
Domain	FAST_2	FASTKD1 FASTKD5	4.20e-04	6	100	2	IPR013579
Domain	RAP	FASTKD1 FASTKD5	4.20e-04	6	100	2	IPR013584
Domain	LysoPLipase_cat_dom	PLA2G4D PLA2G4F	5.86e-04	7	100	2	IPR002642
Domain	PLA2_B	PLA2G4D PLA2G4F	5.86e-04	7	100	2	PF01735
Domain	PLA2C	PLA2G4D PLA2G4F	5.86e-04	7	100	2	PS51210
Domain	PLAc	PLA2G4D PLA2G4F	5.86e-04	7	100	2	SM00022
Domain	Leu-rich_rpt	LRRC8E LRRC63 LGR5 ERBIN RSU1 LRR1 LRRC7	6.36e-04	271	100	7	IPR001611
Domain	PH-BEACH_dom	NBEAL1 LYST	7.78e-04	8	100	2	IPR023362
Domain	-	NBEAL1 LYST	7.78e-04	8	100	2	2.30.29.40
Domain	PH_BEACH	NBEAL1 LYST	7.78e-04	8	100	2	PS51783
Domain	cNMP	RAPGEF6 KCNH8 KCNH4	7.90e-04	34	100	3	SM00100
Domain	cNMP_binding	RAPGEF6 KCNH8 KCNH4	7.90e-04	34	100	3	PF00027
Domain	cNMP-bd_dom	RAPGEF6 KCNH8 KCNH4	8.61e-04	35	100	3	IPR000595
Domain	CNMP_BINDING_3	RAPGEF6 KCNH8 KCNH4	8.61e-04	35	100	3	PS50042
Domain	PDZ	RAPGEF6 ERBIN TIAM2 TIAM1 LRRC7	9.68e-04	141	100	5	PF00595
Domain	BEACH_dom	NBEAL1 LYST	9.97e-04	9	100	2	IPR000409
Domain	BEACH	NBEAL1 LYST	9.97e-04	9	100	2	PS50197
Domain	Beach	NBEAL1 LYST	9.97e-04	9	100	2	PF02138
Domain	-	NBEAL1 LYST	9.97e-04	9	100	2	1.10.1540.10
Domain	Beach	NBEAL1 LYST	9.97e-04	9	100	2	SM01026
Domain	cNMP-bd-like	RAPGEF6 KCNH8 KCNH4	1.10e-03	38	100	3	IPR018490
Domain	LRR_1	LRRC8E LGR5 ERBIN RSU1 LRR1 LRRC7	1.16e-03	219	100	6	PF00560
Domain	PDZ	RAPGEF6 ERBIN TIAM2 TIAM1 LRRC7	1.20e-03	148	100	5	SM00228
Domain	PAS_9	KCNH8 KCNH4	1.24e-03	10	100	2	PF13426
Domain	-	RAPGEF6 ERBIN TIAM2 TIAM1 LRRC7	1.28e-03	150	100	5	2.30.42.10
Domain	PDZ	RAPGEF6 ERBIN TIAM2 TIAM1 LRRC7	1.31e-03	151	100	5	PS50106
Domain	PDZ	RAPGEF6 ERBIN TIAM2 TIAM1 LRRC7	1.35e-03	152	100	5	IPR001478
Domain	Ser/Thr-sp_prot-phosphatase	PPP2CA PPP2CB	2.13e-03	13	100	2	IPR006186
Domain	-	NGB ADGB	2.13e-03	13	100	2	1.10.490.10
Domain	SER_THR_PHOSPHATASE	PPP2CA PPP2CB	2.13e-03	13	100	2	PS00125
Domain	Globin/Proto	NGB ADGB	2.13e-03	13	100	2	IPR012292
Domain	PP2Ac	PPP2CA PPP2CB	2.13e-03	13	100	2	SM00156
Domain	-	RAPGEF6 KCNH8 KCNH4	2.16e-03	48	100	3	2.60.120.10
Domain	ARM-type_fold	NBEAL1 USP9X USP9Y LYST URB1 ELMO2 AGTPBP1	2.31e-03	339	100	7	IPR016024
Domain	Dynein_heavy_chain_D4_dom	DNAH2 DNAH1	2.48e-03	14	100	2	IPR024317
Domain	K_chnl_volt-dep_EAG/ELK/ERG	KCNH8 KCNH4	2.48e-03	14	100	2	IPR003938
Domain	Dynein_HC_stalk	DNAH2 DNAH1	2.48e-03	14	100	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH2 DNAH1	2.48e-03	14	100	2	IPR013602
Domain	DHC_N2	DNAH2 DNAH1	2.48e-03	14	100	2	PF08393
Domain	MT	DNAH2 DNAH1	2.48e-03	14	100	2	PF12777
Domain	AAA_8	DNAH2 DNAH1	2.48e-03	14	100	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH2 DNAH1	2.48e-03	14	100	2	IPR011704
Domain	AAA_5	DNAH2 DNAH1	2.48e-03	14	100	2	PF07728
Domain	RmlC-like_jellyroll	RAPGEF6 KCNH8 KCNH4	2.57e-03	51	100	3	IPR014710
Domain	DHC_fam	DNAH2 DNAH1	2.85e-03	15	100	2	IPR026983
Domain	Dynein_heavy_dom	DNAH2 DNAH1	2.85e-03	15	100	2	IPR004273
Domain	Dynein_heavy	DNAH2 DNAH1	2.85e-03	15	100	2	PF03028
Domain	Acyl_Trfase/lysoPLipase	PLA2G4D PLA2G4F	3.66e-03	17	100	2	IPR016035
Domain	RUN	DENND5B PLEKHM2	4.11e-03	18	100	2	SM00593
Domain	RUN	DENND5B PLEKHM2	4.57e-03	19	100	2	PS50826
Domain	RUN	DENND5B PLEKHM2	4.57e-03	19	100	2	PF02759
Domain	Run_dom	DENND5B PLEKHM2	4.57e-03	19	100	2	IPR004012
Pubmed	Novel Cul3 binding proteins function to remodel E3 ligase complexes.	BTBD1 ERBIN LRR1 PWP2 LRRC7	1.25e-07	40	103	5	25011449
Pubmed	Two immunologically distinct human DNA polymerase alpha-primase subpopulations are involved in cellular DNA replication.	MCM2 PPP2CA PPP2CB	5.44e-06	12	103	3	11259605
Pubmed	Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A.	PPP2CA PPP2CB	8.69e-06	2	103	2	2555176
Pubmed	Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa.	CERS2 CFTR	8.69e-06	2	103	2	25085879
Pubmed	Regulation of spindle formation by active mitogen-activated protein kinase and protein phosphatase 2A during mouse oocyte meiosis.	PPP2CA PPP2CB	8.69e-06	2	103	2	11751260
Pubmed	Ubiquitin-specific protease activity of USP9Y, a male infertility gene on the Y chromosome.	USP9X USP9Y	8.69e-06	2	103	2	12895410
Pubmed	Roles of STEF/Tiam1, guanine nucleotide exchange factors for Rac1, in regulation of growth cone morphology.	TIAM2 TIAM1	8.69e-06	2	103	2	14550769
Pubmed	The Drosophila developmental gene fat facets has a human homologue in Xp11.4 which escapes X-inactivation and has related sequences on Yq11.2.	USP9X USP9Y	8.69e-06	2	103	2	8922996
Pubmed	Regional expression of protein phosphatase type 1 and 2A catalytic subunit isoforms in the human heart.	PPP2CA PPP2CB	8.69e-06	2	103	2	11113010
Pubmed	Crystallographic characterization of the membrane-targeting domains of the Rac-specific guanine nucleotide-exchange factors Tiam1 and Tiam2.	TIAM2 TIAM1	8.69e-06	2	103	2	18997336
Pubmed	The role of protein phosphatase 2A catalytic subunit Calpha in embryogenesis: evidence from sequence analysis and localization studies.	PPP2CA PPP2CB	8.69e-06	2	103	2	10543450
Pubmed	Usp9y (ubiquitin-specific protease 9 gene on the Y) is associated with a functional promoter and encodes an intact open reading frame homologous to Usp9x that is under selective constraint.	USP9X USP9Y	8.69e-06	2	103	2	12925892
Pubmed	Protein phosphatase 2A in the healthy and failing heart: New insights and therapeutic opportunities.	PPP2CA PPP2CB	8.69e-06	2	103	2	34902541
Pubmed	Human liver phosphatase 2A: cDNA and amino acid sequence of two catalytic subunit isotypes.	PPP2CA PPP2CB	8.69e-06	2	103	2	2837763
Pubmed	Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes.	PPP2CA PPP2CB	8.69e-06	2	103	2	1846293
Pubmed	Characterization of STEF, a guanine nucleotide exchange factor for Rac1, required for neurite growth.	TIAM2 TIAM1	8.69e-06	2	103	2	11707441
Pubmed	PP2A regulates kinetochore-microtubule attachment during meiosis I in oocyte.	PPP2CA PPP2CB	8.69e-06	2	103	2	27096707
Pubmed	Replication factors MCM2 and ORC1 interact with the histone acetyltransferase HBO1.	MCM2 KAT7	8.69e-06	2	103	2	11278932
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	LRRC8E RAPGEF6 MYO1E TMEM94 BIRC6 LYST RYR1 TIAM2 PCNX2 PPP2CB URB1 PLEKHM2 RASAL1	2.38e-05	1105	103	13	35748872
Pubmed	Tyrosine phosphorylation of protein phosphatase 2A in response to growth stimulation and v-src transformation of fibroblasts.	PPP2CA PPP2CB	2.60e-05	3	103	2	7510677
Pubmed	SNX17 Recruits USP9X to Antagonize MIB1-Mediated Ubiquitination and Degradation of PCM1 during Serum-Starvation-Induced Ciliogenesis.	USP9X SNX17	2.60e-05	3	103	2	31671755
Pubmed	PP2A Deficiency Enhances Carcinogenesis of Lgr5+ Intestinal Stem Cells Both in Organoids and In Vivo.	LGR5 PPP2CA	2.60e-05	3	103	2	31905853
Pubmed	The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo.	PPP2CA PPP2CB	2.60e-05	3	103	2	8206937
Pubmed	Distribution and functional properties of human KCNH8 (Elk1) potassium channels.	KCNH8 KCNH4	2.60e-05	3	103	2	12890647
Pubmed	mAKAP and the ryanodine receptor are part of a multi-component signaling complex on the cardiomyocyte nuclear envelope.	RYR1 PPP2CA	2.60e-05	3	103	2	11590243
Pubmed	The DNA translocase FANCM/MHF promotes replication traverse of DNA interstrand crosslinks.	MCM2 FANCM	2.60e-05	3	103	2	24207054
Pubmed	Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2.	PPP2CA PPP2CB	2.60e-05	3	103	2	10441131
Pubmed	Protein phosphatase 2A dephosphorylates CaBP4 and regulates CaBP4 function.	PPP2CA PPP2CB	2.60e-05	3	103	2	23341017
Pubmed	Localization of the genes encoding the catalytic subunits of protein phosphatase 2A to human chromosome bands 5q23-->q31 and 8p12-->p11.2, respectively.	PPP2CA PPP2CB	2.60e-05	3	103	2	8383590
Pubmed	Overlapping binding sites in protein phosphatase 2A for association with regulatory A and alpha-4 (mTap42) subunits.	PPP2CA PPP2CB	2.60e-05	3	103	2	15252037
Pubmed	Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis.	USP9X CFTR ERBIN PPP2CA PPP2CB TIAM1	2.62e-05	195	103	6	17110338
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SNX17 MCM2 NCSTN TIAM2 ST6GAL2 NRXN3 ATP11B ANAPC2 OGA	2.88e-05	529	103	9	14621295
Pubmed	Comparative Host Interactomes of the SARS-CoV-2 Nonstructural Protein 3 and Human Coronavirus Homologs.	MYO1E TOR1A NCSTN BIRC6 URB1 LRRC7 TMEM181	2.97e-05	296	103	7	34186245
Pubmed	Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.	CA11 DENND5B CMTM3 NRDC CFTR LGR5 ERBIN ATP11B PIGF KYAT3	3.79e-05	686	103	10	29987050
Pubmed	Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.	TMEM94 ZNF618 USP9X USP9Y RSU1 PRUNE1 PPP2CA PPP2CB	4.51e-05	432	103	8	23455922
Pubmed	DONSON and FANCM associate with different replisomes distinguished by replication timing and chromatin domain.	MCM2 FANCM	5.19e-05	4	103	2	32769987
Pubmed	The E3 ubiquitin ligase- and protein phosphatase 2A (PP2A)-binding domains of the Alpha4 protein are both required for Alpha4 to inhibit PP2A degradation.	PPP2CA PPP2CB	5.19e-05	4	103	2	21454489
Pubmed	Interaction of the protein phosphatase 2A with the regulatory domain of the cystic fibrosis transmembrane conductance regulator channel.	CFTR PPP2CB	5.19e-05	4	103	2	15936019
Pubmed	Generation of Ppp2Ca and Ppp2Cb conditional null alleles in mouse.	PPP2CA PPP2CB	5.19e-05	4	103	2	21998041
Pubmed	Phosphatase activity toward abnormally phosphorylated tau: decrease in Alzheimer disease brain.	PPP2CA PPP2CB	5.19e-05	4	103	2	7616230
Pubmed	Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain.	PPP2CA PPP2CB	5.19e-05	4	103	2	9920888
Pubmed	Cftr Modulates Wnt/β-Catenin Signaling and Stem Cell Proliferation in Murine Intestine.	CFTR LGR5	5.19e-05	4	103	2	29675451
Pubmed	Phosphorylation and microtubule association of the Opitz syndrome protein mid-1 is regulated by protein phosphatase 2A via binding to the regulatory subunit alpha 4.	PPP2CA PPP2CB	5.19e-05	4	103	2	11371618
Pubmed	The in vivo roles of STEF/Tiam1, Rac1 and JNK in cortical neuronal migration.	TIAM2 TIAM1	5.19e-05	4	103	2	12912917
Pubmed	The phosphorylation state of an autoregulatory domain controls PACS-1-directed protein traffic.	PPP2CA PPP2CB	5.19e-05	4	103	2	14633983
Pubmed	Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Calpha.	PPP2CA PPP2CB	5.19e-05	4	103	2	9770493
Pubmed	The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding module.	TIAM2 TIAM1	5.19e-05	4	103	2	19893486
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	CDKL2 ZNF618 DNAH2 PPFIA3 BIRC6 RYR1 SLC5A2 URB1 DROSHA LRRC7	6.82e-05	736	103	10	29676528
Pubmed	A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins.	CFTR P2RY1	8.64e-05	5	103	2	9671706
Pubmed	Identification of novel cytosolic phospholipase A(2)s, murine cPLA(2){delta}, {epsilon}, and {zeta}, which form a gene cluster with cPLA(2){beta}.	PLA2G4D PLA2G4F	8.64e-05	5	103	2	15866882
Pubmed	Regulation of replication licensing by acetyltransferase Hbo1.	MCM2 KAT7	8.64e-05	5	103	2	16428461
Pubmed	The AAA+ protein torsinA interacts with a conserved domain present in LAP1 and a novel ER protein.	TOR1A LRRC7	8.64e-05	5	103	2	15767459
Pubmed	Mesenchymal dysplasia: a recessive mutation on chromosome 13 of the mouse.	LYST AGTPBP1	8.64e-05	5	103	2	8830098
Pubmed	Regulation of phosphorylation of neuronal microtubule-associated proteins MAP1b and MAP2 by protein phosphatase-2A and -2B in rat brain.	PPP2CA PPP2CB	8.64e-05	5	103	2	10640627
Pubmed	The FASTK family of proteins: emerging regulators of mitochondrial RNA biology.	FASTKD1 FASTKD5	8.64e-05	5	103	2	29036396
Pubmed	IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis.	CFTR NLRC4	8.64e-05	5	103	2	26972847
Pubmed	Involvement of Tiam1, RhoG and ELMO2/ILK in Rac1-mediated phagocytosis in human trabecular meshwork cells.	TIAM1 ELMO2	8.64e-05	5	103	2	27539661
Pubmed	HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint.	PPP2CA PPP2CB	8.64e-05	5	103	2	9009195
Pubmed	Protein phosphatase 2A interacts with and directly dephosphorylates RelA.	PPP2CA PPP2CB	8.64e-05	5	103	2	11591705
Pubmed	Targeted disruption of the PME-1 gene causes loss of demethylated PP2A and perinatal lethality in mice.	PPP2CA PPP2CB	8.64e-05	5	103	2	18596935
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	CERS2 RAPGEF6 NRDC NCSTN ERBIN TIAM2 KAT7 URB1 SLC7A3 RLIM TMEM181 KIF11	8.93e-05	1084	103	12	11544199
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	MAN1A1 USP9X DNAH2 FASTKD5 PSMD8 NCSTN BTBD1 URB1 ANAPC2 OGA KIF11	1.12e-04	942	103	11	31073040
Pubmed	Distinct role of protein phosphatase 2A subunit Calpha in the regulation of E-cadherin and beta-catenin during development.	PPP2CA PPP2CB	1.29e-04	6	103	2	10781942
Pubmed	STRIPAK components determine mode of cancer cell migration and metastasis.	PPP2CA PPP2CB	1.29e-04	6	103	2	25531779
Pubmed	Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration.	FASTKD1 FASTKD5	1.29e-04	6	103	2	20869947
Pubmed	Endotoxin conditioning induces VCP/p97-mediated and inducible nitric-oxide synthase-dependent Tyr284 nitration in protein phosphatase 2A.	PPP2CA PPP2CB	1.29e-04	6	103	2	20100830
Pubmed	Global loss of leucine carboxyl methyltransferase-1 causes severe defects in fetal liver hematopoiesis.	PPP2CA PPP2CB	1.29e-04	6	103	2	29735529
Pubmed	Protein phosphorylation of human brain glutamic acid decarboxylase (GAD)65 and GAD67 and its physiological implications.	PPP2CA PPP2CB	1.29e-04	6	103	2	15147202
Pubmed	Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease.	GSAP NCSTN	1.29e-04	6	103	2	20811458
Pubmed	Alpha 4 associates with protein phosphatases 2A, 4, and 6.	PPP2CA PPP2CB	1.29e-04	6	103	2	9647778
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	CERS2 CDKL2 USP9X TOR1A FASTKD5 PSMD8 NCSTN BIRC6 ELMO2	1.50e-04	657	103	9	36180527
Pubmed	Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment.	DNAH2 DNAH1	1.81e-04	7	103	2	9256245
Pubmed	X-linked microtubule-associated protein, Mid1, regulates axon development.	PPP2CA PPP2CB	1.81e-04	7	103	2	24194544
Pubmed	The ubiquitin E3 ligase NOSIP modulates protein phosphatase 2A activity in craniofacial development.	PPP2CA PPP2CB	1.81e-04	7	103	2	25546391
Pubmed	GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin.	PPP2CA PPP2CB	1.81e-04	7	103	2	10698523
Pubmed	Genome-wide association study of prognosis in advanced non-small cell lung cancer patients receiving platinum-based chemotherapy.	CFTR NRXN3	1.81e-04	7	103	2	22872573
Pubmed	Comparative analysis of the mouse and human genes (Matn2 and MATN2) for matrilin-2, a filament-forming protein widely distributed in extracellular matrices.	NPR3 SEMA5A	1.81e-04	7	103	2	11852232
Pubmed	Protein phosphatase 2A and separase form a complex regulated by separase autocleavage.	PPP2CA PPP2CB	1.81e-04	7	103	2	17604273
Pubmed	Control of APC/C-dependent ubiquitin chain elongation by reversible phosphorylation.	PPP2CA PPP2CB ANAPC2	1.82e-04	37	103	3	26811472
Pubmed	p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected].	PPP2CA PPP2CB	2.40e-04	8	103	2	1330687
Pubmed	Genetic analysis of Down syndrome-associated heart defects in mice.	URB1 TIAM1	2.40e-04	8	103	2	21442329
Pubmed	Type 2A protein phosphatase, the complex regulator of numerous signaling pathways.	PPP2CA PPP2CB	2.40e-04	8	103	2	11007961
Pubmed	Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation.	PPP2CA PPP2CB	2.40e-04	8	103	2	16262633
Pubmed	Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A.	PPP2CA PPP2CB	2.40e-04	8	103	2	12912990
Pubmed	Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy.	PPP2CA PPP2CB	2.40e-04	8	103	2	35768646
Pubmed	Female-biased embryonic death from inflammation induced by genomic instability.	MCM2 FANCM	2.40e-04	8	103	2	30787433
Pubmed	Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution.	PPP2CA PPP2CB	2.40e-04	8	103	2	12370081
Pubmed	Enriching the Housing Environment for Mice Enhances Their NK Cell Antitumor Immunity via Sympathetic Nerve-Dependent Regulation of NKG2D and CCR5.	LYST CCR5	2.40e-04	8	103	2	28082402
Pubmed	Akt and PP2A reciprocally regulate the guanine nucleotide exchange factor Dock6 to control axon growth of sensory neurons.	PPP2CA PPP2CB	2.40e-04	8	103	2	23462102
Pubmed	Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.	NBEAL1 USP9X BTBD1 LYST RYR1 KAT7 ATP11B FAM180A	2.43e-04	552	103	8	10737800
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	ATAD5 USP9X SNX17 PSMD8 PPFIA3 BIRC6 ERBIN PPP2CA PPP2CB TIAM1 AGTPBP1	2.84e-04	1049	103	11	27880917
Pubmed	Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	FASTKD1 FASTKD5 ST6GAL2 ELMO2	2.96e-04	107	103	4	11347906
Pubmed	Identification of the nuclear receptor CAR:HSP90 complex in mouse liver and recruitment of protein phosphatase 2A in response to phenobarbital.	PPP2CA PPP2CB	3.08e-04	9	103	2	12885400
Pubmed	Differential expression of the catalytic subunits for PP-1 and PP-2A and the regulatory subunits for PP-2A in mouse eye.	PPP2CA PPP2CB	3.08e-04	9	103	2	18432318
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	KCNH8 USP9X DNAH2 TOR1A KCNH4 KAT7 PPP2CA PLA2G4F KIF11	3.27e-04	730	103	9	34857952
Pubmed	A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein.	PPFIA3 PPP2CA PPP2CB	3.49e-04	46	103	3	18782753
Pubmed	Dynein and kinesin regulate stress-granule and P-body dynamics.	DNAH2 DNAH1	3.85e-04	10	103	2	19825938
Pubmed	Bimodal regulation of an Elk subfamily K+ channel by phosphatidylinositol 4,5-bisphosphate.	KCNH8 KCNH4	3.85e-04	10	103	2	26503718
Pubmed	Characterisation of the coding sequence and fine mapping of the human DFFRY gene and comparative expression analysis and mapping to the Sxrb interval of the mouse Y chromosome of the Dffry gene.	USP9X USP9Y	3.85e-04	10	103	2	9384609
Pubmed	Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer.	PCNX2 UGT2B10 KYAT3 ACSBG2	4.03e-04	116	103	4	30652415
GeneFamily	PDZ domain containing	RAPGEF6 ERBIN TIAM2 TIAM1 LRRC7	3.50e-04	152	72	5	1220
GeneFamily	WD repeat domain containing\|BEACH domain containing	NBEAL1 LYST	5.53e-04	9	72	2	1230
GeneFamily	Protein phosphatase catalytic subunits\|EF-hand domain containing	PPP2CA PPP2CB	1.19e-03	13	72	2	693
GeneFamily	Dyneins, axonemal	DNAH2 DNAH1	2.05e-03	17	72	2	536
GeneFamily	Phospholipases\|C2 domain containing phospholipases	PLA2G4D PLA2G4F	2.56e-03	19	72	2	832
GeneFamily	Protein phosphatase catalytic subunits\|STRIPAK complex	PPP2CA PPP2CB	2.84e-03	20	72	2	1371
GeneFamily	Guanylate cyclase receptors\|DENN/MADD domain containing	DENND5B NPR3	4.42e-03	25	72	2	504
Coexpression	GSE24142_DN2_VS_DN3_THYMOCYTE_ADULT_DN	SLC29A3 RAPGEF6 NRDC USP9X LYST GFRA1 RYR1 RGS14	1.14e-06	199	102	8	M4567
ToppCell	Globus_pallidus-Neuronal-Excitatory\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	CA11 RYR1 TIAM2 KCNH4 RGS14 OGA RASAL1	9.38e-08	160	103	7	f843287ed57d2d5a3b3f6dfb03b6934e330e6645
ToppCell	Globus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	CA11 RYR1 TIAM2 KCNH4 RGS14 OGA RASAL1	9.79e-08	161	103	7	ebcd5066e82b7760b9da6adc02d11258d1309dab
ToppCell	356C-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|356C / Donor, Lineage, Cell class and subclass (all cells)	NPR3 ATAD5 MCM2 CRHBP ST6GAL2 KIF11	4.04e-06	181	103	6	be4f35c9eb5b3083acb2264128f095fac1f3da45
ToppCell	LPS_only-Endothelial-Endothelial-FOXM1\|LPS_only / Treatment groups by lineage, cell group, cell type	CERS2 ATAD5 RYR1 KAT7 P2RY1 RLIM	6.56e-06	197	103	6	038fd92750257d43d5e980fd06d77742b543f11a
Drug	Butamben [94-25-7]; Up 200; 20.6uM; MCF7; HT_HG-U133A	COLGALT2 GSAP RYR1 SLC5A2 RGS14 PPP2CB URB1 ACSBG2	3.21e-06	199	102	8	6093_UP
Disease	brain disease (implicated_via_orthology)	TIAM2 TIAM1 DROSHA	7.73e-07	6	101	3	DOID:936 (implicated_via_orthology)
Disease	cataract 48 (implicated_via_orthology)	TIAM2 TIAM1	1.16e-05	2	101	2	DOID:0070354 (implicated_via_orthology)
Disease	Alcoholic Intoxication, Chronic	NRDC CFTR NPSR1 SEMA5A CRHBP NRXN3	3.27e-04	268	101	6	C0001973
Disease	pulmonary sarcoidosis (is_implicated_in)	CFTR CCR5	4.11e-04	9	101	2	DOID:13406 (is_implicated_in)
Disease	Chagas cardiomyopathy	NPR3 TIAM1 PLA2G4F	4.66e-04	44	101	3	EFO_0005529
Disease	Male sterility	CFTR ENO4 DROSHA	6.02e-04	48	101	3	C0917731
Disease	Male infertility	CFTR ENO4 DROSHA	6.02e-04	48	101	3	C0021364
Disease	Subfertility, Male	CFTR ENO4 DROSHA	6.02e-04	48	101	3	C0848676
Disease	peanut allergy measurement, parental genotype effect measurement	RYR1 ADGB	6.25e-04	11	101	2	EFO_0005939, EFO_0007017
Disease	Drug habituation	CFTR CHD1L TIAM2 NRXN3	6.68e-04	115	101	4	C0013170
Disease	Substance-Related Disorders	CFTR CHD1L TIAM2 NRXN3	6.68e-04	115	101	4	C0236969
Disease	Drug abuse	CFTR CHD1L TIAM2 NRXN3	6.68e-04	115	101	4	C0013146
Disease	Drug Use Disorders	CFTR CHD1L TIAM2 NRXN3	6.68e-04	115	101	4	C0013222
Disease	Drug Dependence	CFTR CHD1L TIAM2 NRXN3	6.68e-04	115	101	4	C1510472
Disease	Substance Dependence	CFTR CHD1L TIAM2 NRXN3	6.68e-04	115	101	4	C0038580
Disease	Substance Use Disorders	CFTR CHD1L TIAM2 NRXN3	6.68e-04	115	101	4	C0038586
Disease	Organic Mental Disorders, Substance-Induced	CFTR CHD1L TIAM2 NRXN3	6.68e-04	115	101	4	C0029231
Disease	Prescription Drug Abuse	CFTR CHD1L TIAM2 NRXN3	6.68e-04	115	101	4	C4316881
Disease	Substance abuse problem	CFTR CHD1L TIAM2 NRXN3	6.90e-04	116	101	4	C0740858
Disease	triacylglycerol 50:5 measurement	LRRC8E SNX17	1.35e-03	16	101	2	EFO_0010412

Protein segments in the cluster

Peptide	Gene	Start	Entry
AEFFLSLDIPIGELY	ACSBG2	406	Q5FVE4
FLYSNLEFILPLPVD	ATAD5	1506	Q96QE3
TQLYLNDAFLEFLPA	ERBIN	141	Q96RT1
LLDAFGLLESRLDPY	ANAPC2	111	Q9UJX6
ADLYLLDSPFGYLDV	CFTR	566	P13569
YDLPALLDQELFELL	BIRC6	3511	Q9NR09
DNNLLLPATTYEFEL	ADGB	221	Q8N7X0
PTLLDALLQNLYDFG	C1orf131	26	Q8NDD1
LALAYFRFEDLPEDL	ACOT6	186	Q3I5F7
AYFLQDLSLELLFPE	CA11	216	O75493
DIYLLNLAISDLFFL	CCR5	66	P51681
YNLPSSLLDFENDLI	AGTPBP1	1146	Q9UPW5
FELYVATPLAALLNI	CERS2	56	Q96G23
LVLLPQDDSYLFSLT	NPR3	56	P17342
LFEPGNADILYALLL	NBEAL1	1131	Q6ZS30
LPLDFHQLAFYVLDE	RASAL1	61	O95294
LAYEDFSFPIFLLED	NCSTN	171	Q92542
LLGFSDYLELQIPLF	OR5D16	16	Q8NGK9
DYLELQIPLFFVFLA	OR5D16	21	Q8NGK9
YFLPEAPAELLQIFD	MCM2	246	P49736
PVDIYLNLLRTIFDF	PGM5	196	Q15124
PELVFLEFFEALLSF	RSPH10B	621	P0C881
PELVFLEFFEALLSF	RSPH10B2	621	B2RC85
LLPLLQEALSAYFDS	PRUNE1	351	Q86TP1
LLEPLDFESLTQYNL	DCHS1	2556	Q96JQ0
FNLALADFLYVLTLP	P2RY1	91	P47900
PLLENLTSEYDLDLF	KAT7	296	O95251
NFYPLGEDIDIIFNL	NLRC4	116	Q9NPP4
FLFDILDNFNLLPDT	NPSR1	291	Q6W5P4
FLPSEFRNLSLEYLD	LRR1	286	Q96L50
TQLYLNDAFLEFLPA	LRRC7	141	Q96NW7
LEIYNEELFDLLNPS	KIF11	161	P52732
ETFDYSDLALLLQIP	PPFIA3	1076	O75145
SSNLFLPFEEELYIV	FANCM	956	Q8IYD8
YYNLGPELELALFLV	GDF3	136	Q9NR23
YPALILNALTIDAFL	PCNX2	1196	A6NKB5
DFFAVELLDGNLYLL	NRXN3	506	Q9Y4C0
IDLIAALPFDLLYIF	KCNH4	311	Q9UQ05
ALFYELRSLVDLLNP	KCNRG	86	Q8N5I3
LPIGLFSLSYLEELD	LRRC63	406	Q05C16
LSYNALEALPEELFF	LRRC8E	706	Q6NSJ5
FTDLFDYLPLTALVD	PPP2CB	146	P62714
FTDLFDYLPLTALVD	PPP2CA	146	P67775
LILSFDYSLEAPFEV	PLA2G4F	701	Q68DD2
DYEELPELSFILSAL	PCDHB11	201	Q9Y5F2
TILDDLELFPNGLDY	CDKL2	86	Q92772
PRFYFLSDDELLEIL	DNAH1	1326	Q9P2D7
FLPLNYFIEILTDIE	GSAP	806	A4D1B5
GELNFPYLFQLLEDE	HYI	226	Q5T013
FLEYFPVELIDFALS	FASTKD5	481	Q7L8L6
LELREAADYDPFLLF	CRHBP	26	P24387
LYFALPLLDLLLSAE	GFRA1	6	P56159
LELAFSILYDPDETL	ELMO2	631	Q96JJ3
PAAFLALLRFLYSDE	BTBD1	126	Q9H0C5
QELYSLLSFVEPDLF	CHD1L	211	Q86WJ1
LGFSLATLEYFPEDL	FASTKD1	616	Q53R41
LNPLNAYSDLAEFLE	IFIT3	326	O14879
LSDYPLREAFELLGL	DENND5B	266	Q6ZUT9
FPFILADYVSETLDL	LYST	3166	Q99698
LKYLYLIFSDDDLLP	MAN1A1	611	P33908
LEELLNSTFYLQPAD	ENO4	36	A6NNW6
LLYEFLLAELEISPD	FAM180A	56	Q6UWF9
LSEEDPFFLAELLYI	CASP10	71	Q92851
DYILFIDVDNFLTNP	COLGALT2	161	Q8IYK4
FPRFYFLSNDDLLEI	DNAH2	1531	Q9P225
NFLELAESILEYFRP	RYR1	4161	P21817
AEYPDFFALGLVLLL	SLC7A3	161	Q8WY07
YFIIADVSLLDPDLS	KYAT3	371	Q6YP21
LFALEPDLLPLFQYN	NGB	31	Q9NPG2
VLDLSYNLLEDLPSF	LGR5	356	O75473
LDLILSFDYSLSAPF	PLA2G4D	666	Q86XP0
LEFIRFELDLDAPYL	PLEKHM2	146	Q8IWE5
SEDQRPLFALFLIIY	OR1L3	21	Q8NH93
LRALYLSDNDFEILP	RSU1	136	Q15404
FIPLTTFLLYNFADL	SLC29A3	346	Q9BZD2
ELIDDFIFPASNVYL	USP9X	1461	Q93008
ELFSLFLFRDILELY	DROSHA	646	Q9NRR4
EDFLLTYRTFLESPL	RAPGEF6	441	Q8TEU7
EDLQLLADLFYLPYE	OGA	556	O60502
YGAPLIELALETFLF	PIGF	101	Q07326
LLFLLIFIYFTDSNP	ST6GAL2	21	Q96JF0
GLYDPCFLLQLFSEL	URB1	1636	O60287
LQSTFFLPELDLIYG	SEMA5A	291	Q13591
PLLEFLLALYFLFAD	CMTM3	71	Q96MX0
DFLAFLVLYNFIIPI	ATP11B	341	Q9Y2G3
DLPDDLIGYFSLFLV	SNX17	151	Q15036
DYLQEPLFQATPDLF	ZNF618	876	Q5T7W0
SLIDRNLIDYFVPFL	TOR1A	256	O14656
YPLLLRELFALTDAE	TIAM1	1196	Q13009
KDLSCLFELYLEPLQ	TIAM2	1116	Q8IVF5
LFELYLEPLQNETFL	TIAM2	1121	Q8IVF5
DNPADILVIAAYFLL	SLC5A2	21	P31639
LFLQSDISIALDPLY	TMEM94	1011	Q12767
LLLLYNDPFFPLSFL	TMEM181	356	Q9P2C4
LIYSLDTRVLFDPFE	PWP2	726	Q15269
LPFLSLAQFFLLNED	RLIM	526	Q9NVW2
LLFDYEIEKEPLLFH	TMEM53	96	Q6P2H8
ALLLYLFNLALVDEF	nan	91	Q7L0L9
PLLFQLIIDYLAEFN	NRDC	771	O43847
LLQDPLGLAYFTEFL	RGS14	71	O43566
PYLDLLFQILLIEDS	USP9Y	2336	O00507
NLDFSDFLFPIVLLS	PRSS48	271	Q7RTY5
LLYIPSQSELLDFLS	TXNDC11	216	Q6PKC3
GELLAELFNIPFVYS	UGT2B10	156	P36537
IPAESYTFFIDILLD	PSMD8	251	P48556
DLIAALPFDLLYAFN	KCNH8	306	Q96L42
SEEFLAFPAYLLGIN	MYO1E	301	Q12965