Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	RFX1_trans_act	RFX1 RFX2	3.35e-05	3	63	2	IPR007668
Domain	RFX1_trans_act	RFX1 RFX2	3.35e-05	3	63	2	PF04589
Domain	WxxW_domain	MUC5B MUC5AC	1.67e-04	6	63	2	IPR025155
Domain	Mucin2_WxxW	MUC5B MUC5AC	1.67e-04	6	63	2	PF13330
Domain	RFX_DNA_binding	RFX1 RFX2	3.97e-04	9	63	2	PF02257
Domain	DNA-bd_RFX	RFX1 RFX2	3.97e-04	9	63	2	IPR003150
Domain	RFX_DBD	RFX1 RFX2	3.97e-04	9	63	2	PS51526
Domain	TIL	MUC5B MUC5AC	7.23e-04	12	63	2	PF01826
Domain	C8	MUC5B MUC5AC	7.23e-04	12	63	2	PF08742
Domain	Unchr_dom_Cys-rich	MUC5B MUC5AC	8.53e-04	13	63	2	IPR014853
Domain	C8	MUC5B MUC5AC	8.53e-04	13	63	2	SM00832
Domain	Dynein_heavy_chain_D4_dom	DNAH3 DNAH7	9.93e-04	14	63	2	IPR024317
Domain	Dynein_HC_stalk	DNAH3 DNAH7	9.93e-04	14	63	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH3 DNAH7	9.93e-04	14	63	2	IPR013602
Domain	DHC_N2	DNAH3 DNAH7	9.93e-04	14	63	2	PF08393
Domain	MT	DNAH3 DNAH7	9.93e-04	14	63	2	PF12777
Domain	AAA_8	DNAH3 DNAH7	9.93e-04	14	63	2	PF12780
Domain	TIL_dom	MUC5B MUC5AC	9.93e-04	14	63	2	IPR002919
Domain	DHC_fam	DNAH3 DNAH7	1.14e-03	15	63	2	IPR026983
Domain	PLipase_C_Pinositol-sp_Y	PLCD4 PLCG2	1.14e-03	15	63	2	IPR001711
Domain	EF-hand_like	PLCD4 PLCG2	1.14e-03	15	63	2	PF09279
Domain	PIPLC_Y_DOMAIN	PLCD4 PLCG2	1.14e-03	15	63	2	PS50008
Domain	Glyco_hormone_CN	MUC5B MUC5AC	1.14e-03	15	63	2	IPR006208
Domain	Dynein_heavy_dom	DNAH3 DNAH7	1.14e-03	15	63	2	IPR004273
Domain	Cys_knot	MUC5B MUC5AC	1.14e-03	15	63	2	PF00007
Domain	PI-PLC_fam	PLCD4 PLCG2	1.14e-03	15	63	2	IPR001192
Domain	PLC_EF-hand-like	PLCD4 PLCG2	1.14e-03	15	63	2	IPR015359
Domain	PI-PLC-Y	PLCD4 PLCG2	1.14e-03	15	63	2	PF00387
Domain	PLCYc	PLCD4 PLCG2	1.14e-03	15	63	2	SM00149
Domain	Dynein_heavy	DNAH3 DNAH7	1.14e-03	15	63	2	PF03028
Domain	VWD	MUC5B MUC5AC	1.30e-03	16	63	2	SM00216
Domain	VWF_type-D	MUC5B MUC5AC	1.30e-03	16	63	2	IPR001846
Domain	VWFD	MUC5B MUC5AC	1.30e-03	16	63	2	PS51233
Domain	VWD	MUC5B MUC5AC	1.30e-03	16	63	2	PF00094
Domain	CTCK_1	MUC5B MUC5AC	1.65e-03	18	63	2	PS01185
Domain	PI-PLC-X	PLCD4 PLCG2	1.65e-03	18	63	2	PF00388
Domain	PLCXc	PLCD4 PLCG2	1.65e-03	18	63	2	SM00148
Domain	VWC_out	MUC5B MUC5AC	1.85e-03	19	63	2	SM00215
Domain	PIPLC_X_DOMAIN	PLCD4 PLCG2	1.85e-03	19	63	2	PS50007
Domain	PLipase_C_PInositol-sp_X_dom	PLCD4 PLCG2	1.85e-03	19	63	2	IPR000909
Domain	Myosin-like_IQ_dom	ASPM MYO18B	1.85e-03	19	63	2	IPR027401
Domain	-	ASPM MYO18B	1.85e-03	19	63	2	4.10.270.10
Domain	CT	MUC5B MUC5AC	2.48e-03	22	63	2	SM00041
Domain	-	PLCD4 PLCG2	3.20e-03	25	63	2	3.20.20.190
Domain	Cys_knot_C	MUC5B MUC5AC	3.20e-03	25	63	2	IPR006207
Domain	CTCK_2	MUC5B MUC5AC	3.20e-03	25	63	2	PS01225
Domain	PLC-like_Pdiesterase_TIM-brl	PLCD4 PLCG2	3.20e-03	25	63	2	IPR017946
Domain	TPR_1	CDC16 TTC17 PRPF6	3.49e-03	90	63	3	PF00515
Domain	TPR_1	CDC16 TTC17 PRPF6	3.49e-03	90	63	3	IPR001440
Domain	VWC	MUC5B MUC5AC	4.00e-03	28	63	2	PF00093
Domain	ARM-type_fold	STK36 NOC2L RTTN ASPM RYR3	5.69e-03	339	63	5	IPR016024
Domain	Ank_2	ANKRD44 ANKRD39 ANKRD28 ASB1	5.99e-03	215	63	4	PF12796
Domain	SH2	JAK1 INPPL1 PLCG2	6.11e-03	110	63	3	SM00252
Domain	SH2	JAK1 INPPL1 PLCG2	6.26e-03	111	63	3	PS50001
Domain	SH2	JAK1 INPPL1 PLCG2	6.42e-03	112	63	3	IPR000980
Domain	-	JAK1 INPPL1 PLCG2	6.42e-03	112	63	3	3.30.505.10
Domain	VWFC_1	MUC5B MUC5AC	6.55e-03	36	63	2	PS01208
Domain	PTPc	PTPRM PTPRR	6.55e-03	36	63	2	SM00194
Pathway	REACTOME_DECTIN_2_FAMILY	MUC5B PLCG2 MUC5AC	9.12e-05	26	48	3	M27483
Pathway	REACTOME_SYNTHESIS_OF_IP3_AND_IP4_IN_THE_CYTOSOL	INPPL1 PLCD4 PLCG2	9.12e-05	26	48	3	M27053
Pathway	REACTOME_SYNTHESIS_OF_IP3_AND_IP4_IN_THE_CYTOSOL	INPPL1 PLCD4 PLCG2	1.14e-04	28	48	3	MM14711
Pubmed	Cloning and analysis of cDNA encoding a major airway glycoprotein, human tracheobronchial mucin (MUC5).	MUC5B MUC5AC	3.44e-06	2	65	2	7513696
Pubmed	Airway mucin MUC5AC and MUC5B concentrations and the initiation and progression of chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort.	MUC5B MUC5AC	3.44e-06	2	65	2	34058148
Pubmed	The association between MUC5AC and MUC5B genes expression and remodeling progression in severe neutrophilic asthma: A direct relationship.	MUC5B MUC5AC	3.44e-06	2	65	2	37146737
Pubmed	MUC5AC and MUC5B Mucins Are Decreased in Cystic Fibrosis Airway Secretions.	MUC5B MUC5AC	3.44e-06	2	65	2	14988081
Pubmed	Mucin glycosylation changes in cystic fibrosis lung disease are not manifest in submucosal gland secretions.	MUC5B MUC5AC	3.44e-06	2	65	2	15563276
Pubmed	The expression of MUC5AC and MUC5B mucin genes in the mucosa of chronic rhinosinusitis and nasal polyposis.	MUC5B MUC5AC	3.44e-06	2	65	2	17621824
Pubmed	Muc5b is required for airway defence.	MUC5B MUC5AC	3.44e-06	2	65	2	24317696
Pubmed	Macrophages are related to goblet cell hyperplasia and induce MUC5B but not MUC5AC in human bronchus epithelial cells.	MUC5B MUC5AC	3.44e-06	2	65	2	22391959
Pubmed	C-Mannosylation of MUC5AC and MUC5B Cys subdomains.	MUC5B MUC5AC	3.44e-06	2	65	2	14718370
Pubmed	Mucins MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory Granules.	MUC5B MUC5AC	3.44e-06	2	65	2	35776514
Pubmed	The ocular surface phenotype of Muc5ac and Muc5b null mice.	MUC5B MUC5AC	3.44e-06	2	65	2	24327612
Pubmed	Mucin production during prenatal and postnatal murine lung development.	MUC5B MUC5AC	3.44e-06	2	65	2	21653907
Pubmed	MUC5B mobilizes and MUC5AC spatially aligns mucociliary transport on human airway epithelium.	MUC5B MUC5AC	3.44e-06	2	65	2	36427316
Pubmed	Gel-forming mucins form distinct morphologic structures in airways.	MUC5B MUC5AC	3.44e-06	2	65	2	28607090
Pubmed	Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex.	ANAPC1 CDC16	3.44e-06	2	65	2	11179667
Pubmed	The genes for MHC class II regulatory factors RFX1 and RFX2 are located on the short arm of chromosome 19.	RFX1 RFX2	3.44e-06	2	65	2	1505960
Pubmed	Mucin deficiency causes functional and structural changes of the ocular surface.	MUC5B MUC5AC	3.44e-06	2	65	2	23272068
Pubmed	Muc5b is mainly expressed and sialylated in the nasal olfactory epithelium whereas Muc5ac is exclusively expressed and fucosylated in the nasal respiratory epithelium.	MUC5B MUC5AC	3.44e-06	2	65	2	31030254
Pubmed	Younger patients with COME are more likely to have mucoid middle ear fluid containing mucin MUC5B.	MUC5B MUC5AC	3.44e-06	2	65	2	27729120
Pubmed	The idiopathic pulmonary fibrosis honeycomb cyst contains a mucocilary pseudostratified epithelium.	MUC5B MUC5AC	3.44e-06	2	65	2	23527003
Pubmed	Up-regulation of MUC5AC and MUC5B mucin genes in nasopharyngeal respiratory mucosa and selective up-regulation of MUC5B in middle ear in pediatric otitis media with effusion.	MUC5B MUC5AC	3.44e-06	2	65	2	16540890
Pubmed	De novo NUF2 variant in a novel inherited bone marrow failure syndrome including microcephaly and renal hypoplasia.	MUC5B MUC5AC	3.44e-06	2	65	2	36111525
Pubmed	Abnormalities in MUC5AC and MUC5B Protein in Airway Mucus in Asthma.	MUC5B MUC5AC	3.44e-06	2	65	2	27845589
Pubmed	Contribution of mucus concentration and secreted mucins Muc5ac and Muc5b to the pathogenesis of muco-obstructive lung disease.	MUC5B MUC5AC	3.44e-06	2	65	2	27435107
Pubmed	Mucins MUC5B and MUC5AC in Distal Airways and Honeycomb Spaces: Comparison among Idiopathic Pulmonary Fibrosis/Usual Interstitial Pneumonia, Fibrotic Nonspecific Interstitial Pneumonitis, and Control Lungs.	MUC5B MUC5AC	3.44e-06	2	65	2	26871672
Pubmed	Normal murine respiratory tract has its mucus concentrated in clouds based on the Muc5b mucin.	MUC5B MUC5AC	3.44e-06	2	65	2	32348677
Pubmed	In silico cloning of mouse Muc5b gene and upregulation of its expression in mouse asthma model.	MUC5B MUC5AC	3.44e-06	2	65	2	11587997
Pubmed	Reassessment of the importance of mucins in determining sputum properties in cystic fibrosis.	MUC5B MUC5AC	3.44e-06	2	65	2	24332705
Pubmed	Pathophysiological relevance of sputum MUC5AC and MUC5B levels in patients with mild asthma.	MUC5B MUC5AC	3.44e-06	2	65	2	34656442
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	JAK1 PTPRM RTTN VAMP7 PGAP4 TTC17 ASB1 MFSD8 FAM135A	7.47e-06	719	65	9	35337019
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	TRAP1 CDK5RAP3 ANAPC1 CDC16 ANKRD28 PRPF6 EXOC7 RFX1	9.69e-06	560	65	8	35241646
Pubmed	Interleukin-33 induces mucin gene expression and goblet cell hyperplasia in human nasal epithelial cells.	MUC5B MUC5AC	1.03e-05	3	65	2	27776277
Pubmed	Involvement of RFX proteins in transcriptional activation from a Ras-responsive enhancer element.	RFX1 RFX2	1.03e-05	3	65	2	15024578
Pubmed	High-Mobility Group Box 1 Upregulates MUC5AC and MUC5B Expression in Primary Airway Epithelial Cells.	MUC5B MUC5AC	1.03e-05	3	65	2	29286856
Pubmed	Nebulized Menthol Impairs Mucociliary Clearance via TRPM8 and MUC5AC/MUC5B in Primary Airway Epithelial Cells.	MUC5B MUC5AC	1.03e-05	3	65	2	36675209
Pubmed	Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains.	RFX1 RFX2	1.03e-05	3	65	2	10330134
Pubmed	Ciliogenic RFX transcription factors regulate FGF1 gene promoter.	RFX1 RFX2	1.03e-05	3	65	2	22415835
Pubmed	Th2 cytokines orchestrate the secretion of MUC5AC and MUC5B in IL-5-positive chronic rhinosinusitis with nasal polyps.	MUC5B MUC5AC	1.03e-05	3	65	2	29802623
Pubmed	Autophagy of mucin granules contributes to resolution of airway mucous metaplasia.	MUC5B MUC5AC	1.03e-05	3	65	2	34158522
Pubmed	Drosophila regulatory factor X is necessary for ciliated sensory neuron differentiation.	RFX1 RFX2	1.03e-05	3	65	2	12403718
Pubmed	Resistin upregulates MUC5AC/B mucin gene expression in human airway epithelial cells.	MUC5B MUC5AC	1.03e-05	3	65	2	29604272
Pubmed	IL-8 regulates mucin gene expression at the posttranscriptional level in lung epithelial cells.	MUC5B MUC5AC	1.03e-05	3	65	2	19596978
Pubmed	RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins.	RFX1 RFX2	1.03e-05	3	65	2	8289803
Pubmed	Regulation of neuregulin 1beta1-induced MUC5AC and MUC5B expression in human airway epithelium.	MUC5B MUC5AC	1.03e-05	3	65	2	19556605
Pubmed	Aquaporin 5 expression increases mucin production in lung adenocarcinoma.	MUC5B MUC5AC	1.03e-05	3	65	2	21455588
Pubmed	Interplay of RFX transcription factors 1, 2 and 3 in motile ciliogenesis.	RFX1 RFX2	1.03e-05	3	65	2	32725242
Pubmed	Expression of leptin receptor in nasal polyps: leptin as a mucosecretagogue.	MUC5B MUC5AC	1.03e-05	3	65	2	20422702
Pubmed	Mucin gene polymorphisms in otitis media patients.	MUC5B MUC5AC	1.03e-05	3	65	2	19718741
Pubmed	Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members.	RFX1 RFX2	2.06e-05	4	65	2	11682486
Pubmed	Transcriptional repressor NIR interacts with the p53-inhibiting ubiquitin ligase MDM2.	JAK1 NOC2L	2.06e-05	4	65	2	24413661
Pubmed	ILC2s mediate systemic innate protection by priming mucus production at distal mucosal sites.	MUC5B MUC5AC	2.06e-05	4	65	2	31582416
Pubmed	Differential expression of Rfx1-4 during mouse spermatogenesis.	RFX1 RFX2	2.06e-05	4	65	2	19596083
Pubmed	Increased expression of MUC5AC and MUC5B promoting bacterial biofilm formation in chronic rhinosinusitis patients.	MUC5B MUC5AC	2.06e-05	4	65	2	25638393
Pubmed	Epigenetic regulation (DNA methylation, histone modifications) of the 11p15 mucin genes (MUC2, MUC5AC, MUC5B, MUC6) in epithelial cancer cells.	MUC5B MUC5AC	2.06e-05	4	65	2	17471237
Pubmed	MCP-1/CCR2B-dependent loop upregulates MUC5AC and MUC5B in human airway epithelium.	MUC5B MUC5AC	2.06e-05	4	65	2	21097527
Pubmed	Expression of MUC1, MUC2, MUC5AC and MUC5B in mucinous lesions of the breast.	MUC5B MUC5AC	2.06e-05	4	65	2	22269464
Pubmed	The mouse secreted gel-forming mucin gene cluster.	MUC5B MUC5AC	2.06e-05	4	65	2	14984930
Pubmed	TGF-β₂ decreases baseline and IL-13-stimulated mucin production by primary human bronchial epithelial cells.	MUC5B MUC5AC	2.06e-05	4	65	2	23249391
Pubmed	The RFX family interacts at the collagen (COL1A2) start site and represses transcription.	RFX1 RFX2	2.06e-05	4	65	2	11986307
Pubmed	Effects of the Helicobacter pylori Virulence Factor CagA and Ammonium Ion on Mucins in AGS Cells.	MUC5B MUC5AC	2.06e-05	4	65	2	29869461
Pubmed	Munc13-2-/- baseline secretion defect reveals source of oligomeric mucins in mouse airways.	MUC5B MUC5AC	2.06e-05	4	65	2	18258655
Pubmed	Transcriptional regulation of the Alström syndrome gene ALMS1 by members of the RFX family and Sp1.	RFX1 RFX2	2.06e-05	4	65	2	20381594
Pubmed	Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype.	MUC5B MUC5AC	2.06e-05	4	65	2	23807779
Pubmed	The P522R protective variant of PLCG2 promotes the expression of antigen presentation genes by human microglia in an Alzheimer's disease mouse model.	RAG2 PLCG2	2.06e-05	4	65	2	35142046
Pubmed	Characterization of mouse muc6 and evidence of conservation of the gel-forming mucin gene cluster between human and mouse.	MUC5B MUC5AC	2.06e-05	4	65	2	12676567
Pubmed	Polymorphism of human mucin genes in chest disease: possible significance of MUC2.	MUC5B MUC5AC	3.43e-05	5	65	2	11062147
Pubmed	The DNA damage response mediator MDC1 directly interacts with the anaphase-promoting complex/cyclosome.	ANAPC1 CDC16	3.43e-05	5	65	2	17827148
Pubmed	Distinct calcium channels regulate responses of primary B lymphocytes to B cell receptor engagement and mechanical stimuli.	TRPM2 PLCG2	3.43e-05	5	65	2	15611229
Pubmed	Differential expression of MUC genes in endometrial and cervical tissues and tumors.	MUC5B MUC5AC	3.43e-05	5	65	2	16188033
Pubmed	Expression of Muc19/Smgc gene products during murine sublingual gland development: cytodifferentiation and maturation of salivary mucous cells.	MUC5B MUC5AC	5.13e-05	6	65	2	19110483
Pubmed	Dynamic changes in cis-regulatory occupancy by Six1 and its cooperative interactions with distinct cofactors drive lineage-specific gene expression programs during progressive differentiation of the auditory sensory epithelium.	RFX1 RFX2	5.13e-05	6	65	2	31956913
Pubmed	Differential role of Janus family kinases (JAKs) in interferon-gamma-induced lung epithelial ICAM-1 expression: involving protein interactions between JAKs, phospholipase Cgamma, c-Src, and STAT1.	JAK1 PLCG2	5.13e-05	6	65	2	14978237
Pubmed	IL-13 regulates the immune response to inhaled antigens.	RAG2 LY75	7.18e-05	7	65	2	15944318
Pubmed	Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains.	ANKRD44 ANKRD28	9.56e-05	8	65	2	18186651
Pubmed	Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line.	PLCD4 PLCG2	1.23e-04	9	65	2	7589147
Pubmed	Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2.	ANKRD44 ANKRD28	1.23e-04	9	65	2	21187329
Pubmed	Regulation of the anaphase-promoting complex by the COP9 signalosome.	ANAPC1 CDC16	1.23e-04	9	65	2	19535905
Pubmed	Insulin-like Growth Factor 1 Supports a Pulmonary Niche that Promotes Type 3 Innate Lymphoid Cell Development in Newborn Lungs.	RAG2 TNFSF13	1.23e-04	9	65	2	32075728
Pubmed	Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat.	PLCD4 PLCG2	1.23e-04	9	65	2	10501179
Pubmed	Locations of human and mouse genes encoding the RFX1 and RFX2 transcription factor proteins.	RFX1 RFX2	1.23e-04	9	65	2	8661125
Pubmed	Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons.	ANAPC1 CDC16	1.53e-04	10	65	2	10500174
Pubmed	Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK.	ANAPC1 CDC16	1.53e-04	10	65	2	14744933
Pubmed	Expression of phospholipase C isozymes by murine B lymphocytes.	PLCD4 PLCG2	1.53e-04	10	65	2	2033248
Pubmed	Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex.	ANAPC1 CDC16	1.53e-04	10	65	2	10318877
Pubmed	Physical map of 17p13 and the genes adjacent to p53.	NEUROD2 TNFSF13	1.53e-04	10	65	2	10662545
Pubmed	The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction.	ANAPC1 CDC16	1.53e-04	10	65	2	18997788
Pubmed	Stable MCC binding to the APC/C is required for a functional spindle assembly checkpoint.	ANAPC1 CDC16	1.53e-04	10	65	2	24464857
Pubmed	SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity.	ANAPC1 CDC16	1.53e-04	10	65	2	22014574
Pubmed	Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study.	MUC5B MUC5AC	1.87e-04	11	65	2	24429156
Pubmed	Pih1d3 is required for cytoplasmic preassembly of axonemal dynein in mouse sperm.	DNAAF3 DNAH7	1.87e-04	11	65	2	24421334
Pubmed	Human GW182 Paralogs Are the Central Organizers for RNA-Mediated Control of Transcription.	CDK5RAP3 ANAPC1 CDC16	1.88e-04	59	65	3	28813667
Pubmed	Mitotic regulation of the human anaphase-promoting complex by phosphorylation.	ANAPC1 CDC16	2.24e-04	12	65	2	14657031
Pubmed	Rab40c regulates focal adhesions and PP6 activity by controlling ANKRD28 ubiquitylation.	ANKRD44 ANKRD28	2.24e-04	12	65	2	35512830
Pubmed	Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C.	ANAPC1 CDC16	2.24e-04	12	65	2	16364912
Pubmed	The G2/M regulator histone demethylase PHF8 is targeted for degradation by the anaphase-promoting complex containing CDC20.	ANAPC1 CDC16	2.65e-04	13	65	2	23979597
Pubmed	Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor.	ANAPC1 CDC16	2.65e-04	13	65	2	16921029
Pubmed	LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.	STK36 NOC2L CDC16 RYR3	2.83e-04	168	65	4	30631154
Pubmed	Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?	ANAPC1 RTTN MUC5B DNAH7	2.96e-04	170	65	4	23314748
Pubmed	Human variation in alcohol response is influenced by variation in neuronal signaling genes.	PTPRM PTPRR ENTPD4 RYR3	3.02e-04	171	65	4	20201926
Pubmed	Neuroepithelial body microenvironment is a niche for a distinct subset of Clara-like precursors in the developing airways.	MUC5B MUC5AC	3.08e-04	14	65	2	22797898
Cytoband	Ensembl 112 genes in cytogenetic band chr11p12	RAG2 TTC17	3.32e-04	19	65	2	chr11p12
GeneFamily	Protein phosphatase 6 regulatory subunits	ANKRD44 ANKRD28	8.63e-05	6	44	2	699
GeneFamily	Regulatory factor X family	RFX1 RFX2	1.61e-04	8	44	2	1153
GeneFamily	Anaphase promoting complex \|Tetratricopeptide repeat domain containing	ANAPC1 CDC16	5.17e-04	14	44	2	402
GeneFamily	Dyneins, axonemal	DNAH3 DNAH7	7.69e-04	17	44	2	536
GeneFamily	Phospholipases\|C2 domain containing phospholipases	PLCD4 PLCG2	9.64e-04	19	44	2	832
GeneFamily	Protein tyrosine phosphatases, receptor type	PTPRM PTPRR	1.18e-03	21	44	2	813
GeneFamily	CD molecules\|Mucins	MUC5B MUC5AC	1.18e-03	21	44	2	648
GeneFamily	Ankyrin repeat domain containing	ANKRD44 ANKRD39 ANKRD28 ASB1	2.79e-03	242	44	4	403
GeneFamily	Phospholipases	PLCD4 PLCG2	4.68e-03	42	44	2	467
Disease	primary ciliary dyskinesia (is_implicated_in)	STK36 DNAH7	6.69e-05	6	63	2	DOID:9562 (is_implicated_in)
Disease	pulmonary fibrosis	MUC5B MUC5AC	2.44e-04	11	63	2	EFO_0009448
Disease	anorectal malformation	TRPM2 MUC5B	7.49e-04	19	63	2	MONDO_0019938
Disease	Primary microcephaly	RTTN ASPM	1.01e-03	22	63	2	C0431350
Disease	trans fatty acid measurement, trans/trans-18:2 fatty acid measurement	MYO18B RYR3	1.20e-03	24	63	2	EFO_0006821, EFO_0006826
Disease	pancreatic ductal adenocarcinoma (is_marker_for)	JAK1 PTPRM	1.52e-03	27	63	2	DOID:3498 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
YEQAAAHTHRYLCLD	COG4	151	Q9H9E3
DTYYHAGVNLNLSCH	CEACAM8	246	P31997
LYISAAYHNLQCFRL	ASB1	196	Q9Y576
YSAAYGHRLCLQLIA	ANKRD28	511	O15084
TALHYASRNGHYAVC	ANKRD39	66	Q53RE8
HIRAYLSFHAYAQML	CPA6	316	Q8N4T0
IRLLHFTAAAYYHLN	ASPM	3106	Q8IZT6
HARFGNLSLYLDNHY	MUC5B	5106	Q9HC84
YYCNEHVEIARALHT	RAG2	476	P55895
GYFRLTADAHHYLCT	JAK1	411	P23458
AANCLYAYLHIPASH	MFSD8	116	Q8NHS3
YHLQALRHLYVLAAE	ANAPC1	1601	Q9H1A4
LQRASLAYIHSYSHL	OTOP3	506	Q7RTS5
LYAQVCRHHLAPYLA	MED13L	1501	Q71F56
HAYRFHYTLCATLLL	FAM135A	236	Q9P2D6
LSIFQSHCHYYLQER	PER2	751	O15055
EHHSLYGAARYRLAL	LY75	111	O60449
LASVNHLHLHGYYLA	GDPGP1	211	Q6ZNW5
TIYRHRDLAGHCYYA	MUC5AC	4796	P98088
IHYAAAYGHRQCLEL	ANKRD44	536	Q8N8A2
LACHRLLHSYFYLRH	PGAP4	41	Q9BRR3
YALIQHYRETHLRCA	PLCG2	611	P16885
LYDLTLEYLHSQAHC	NOC2L	526	Q9Y3T9
LSCLDHVISYYHVAS	EXOC7	81	Q9UPT5
FLCTKLHYLDLSYNH	LRRC8B	676	Q6P9F7
QYEFVHHALCLYESR	PTPRR	636	Q15256
DRYVAICAPLHYASH	OR10Z1	121	Q8NGY1
CIQHHTFYIRSYILN	PPP4R3C	521	Q6ZMV5
CLYLTAQYHRAAHAL	CDC16	46	Q13042
CYQLLHEARRYHILG	KLHL24	281	Q6TFL4
HHKSCYNGRFQLLYV	DNAAF3	371	Q8N9W5
YRLCSEQLSSQHHYD	DNAH3	1586	Q8TD57
QLLSGSYIHYFHCLR	CDK5RAP3	56	Q96JB5
SYIHYFHCLRILDLL	CDK5RAP3	61	Q96JB5
RLCSEQLSSQHHYDY	DNAH7	1486	Q8WXX0
NVTRCHSYNLTVHYC	PTPRM	406	P28827
YRLPFCQAHIIAHSY	OR52J3	166	Q8NH60
LHNLCAYCTHILSLY	MTX1	376	Q13505
ALQALLYHCHFYEHL	RTTN	1476	Q86VV8
YYCGSQHRLFNEHLV	SZT2	361	Q5T011
TLAYFIFYHIHRLCL	RNF133	201	Q8WVZ7
NYHDTRIHACLYFIA	SEPTIN11	141	Q9NVA2
LNHYFICSSHNTYLV	PLCD4	296	Q9BRC7
RSTLYCHYLLHCQEQ	RFX1	456	P22670
PRSSLYNHYLRHCQE	RFX2	216	P48378
VAHNALECARAIYAY	PRPF6	551	O94906
LYASHADLHRLKYQC	ENTPD4	476	Q9Y227
FALCVLYQKHVHTYR	INPPL1	56	O15357
RLDQYTHLCLAYKGH	PKHD1	606	P08F94
HYAALAHYFTAILLI	RHPN2	351	Q8IUC4
AAQLVSALYYLHSHR	STK36	106	Q9NRP7
YLSNHAVAALYASAC	ACTRT1	136	Q8TDG2
HLNSHLSEGIYLCQY	ZNF639	421	Q9UID6
YYRHLAPDHLLQICH	PHIP	66	Q8WWQ0
RFHYHTLRLYSAVCA	RYR3	1556	Q15413
DSYHVNARHLLYPNC	TRPM2	1236	O94759
AYLYAAIHHRLVALQ	RANBP3L	396	Q86VV4
YNHSVLCYDHALQAR	TTC17	311	Q96AE7
SHGNYLFHYICQDRI	VAMP7	46	P51809
YYIAHNVADCLHLRG	SMKR1	36	H3BMG3
LCHNYAHERLQLLFY	MYO18B	966	Q8IUG5
NIYYLCAPNRHLAEH	TRAP1	496	Q12931
LYIHCYAHFLDLSII	ZMYM1	741	Q5SVZ6
RAYNSCYSAGVFHLH	TNFSF13	206	O75888
QAYLDDCHRRYSCAH	YPEL3	11	P61236
AAHALRTHGYCAAYE	NEUROD2	261	Q15784