Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	phosphatidylinositol 3-kinase inhibitor activity	WASH3P WASHC1	7.83e-05	8	34	2	GO:0141039
GeneOntologyMolecularFunction	actin binding	WASH3P SSH2 PARVG IQGAP2 SIPA1L1 WASHC1	1.40e-04	479	34	6	GO:0003779
GeneOntologyMolecularFunction	cytoskeletal protein binding	NAV3 NUSAP1 WASH3P SSH2 PARVG IQGAP2 SIPA1L1 WASHC1	4.13e-04	1099	34	8	GO:0008092
GeneOntologyMolecularFunction	phosphatidylinositol 3-kinase regulator activity	WASH3P WASHC1	4.23e-04	18	34	2	GO:0035014
GeneOntologyMolecularFunction	histone binding	DNAJC9 SMARCC2 CHD4 RBBP5	1.03e-03	265	34	4	GO:0042393
GeneOntologyMolecularFunction	low-density lipoprotein particle receptor binding	WASH3P WASHC1	1.53e-03	34	34	2	GO:0050750
GeneOntologyMolecularFunction	gamma-tubulin binding	WASH3P WASHC1	1.90e-03	38	34	2	GO:0043015
GeneOntologyMolecularFunction	lipoprotein particle receptor binding	WASH3P WASHC1	2.00e-03	39	34	2	GO:0070325
GeneOntologyBiologicalProcess	regulation of protein polymerization	NAV3 WASH3P SSH2 WASHC1 VDAC2	2.65e-05	231	32	5	GO:0032271
GeneOntologyBiologicalProcess	positive regulation of cholesterol import	WASH3P WASHC1	3.48e-05	6	32	2	GO:1904109
GeneOntologyBiologicalProcess	cytoskeleton-dependent cytokinesis	NUSAP1 WASH3P IQGAP2 WASHC1	4.31e-05	127	32	4	GO:0061640
GeneOntologyBiologicalProcess	Arp2/3 complex-mediated actin nucleation	WASH3P IQGAP2 WASHC1	5.25e-05	47	32	3	GO:0034314
GeneOntologyBiologicalProcess	regulation of cholesterol import	WASH3P WASHC1	8.34e-05	9	32	2	GO:0060620
GeneOntologyBiologicalProcess	regulation of protein-containing complex assembly	NAV3 WASH3P TFIP11 SSH2 WASHC1 VDAC2	9.24e-05	489	32	6	GO:0043254
GeneOntologyBiologicalProcess	polar body extrusion after meiotic divisions	WASH3P WASHC1	1.04e-04	10	32	2	GO:0040038
GeneOntologyBiologicalProcess	actin nucleation	WASH3P IQGAP2 WASHC1	1.39e-04	65	32	3	GO:0045010
GeneOntologyBiologicalProcess	regulation of organelle organization	NAV3 NUSAP1 SMG1 SMARCC2 WASH3P SSH2 IQGAP2 SIPA1L1 WASHC1	1.45e-04	1342	32	9	GO:0033043
GeneOntologyBiologicalProcess	protein polymerization	NAV3 WASH3P SSH2 WASHC1 VDAC2	1.52e-04	334	32	5	GO:0051258
GeneOntologyBiologicalProcess	meiotic cytokinesis	WASH3P WASHC1	1.80e-04	13	32	2	GO:0033206
GeneOntologyBiologicalProcess	cytokinesis	NUSAP1 WASH3P IQGAP2 WASHC1	2.69e-04	204	32	4	GO:0000910
GeneOntologyBiologicalProcess	cholesterol import	WASH3P WASHC1	2.76e-04	16	32	2	GO:0070508
GeneOntologyBiologicalProcess	regulation of cellular component biogenesis	NAV3 WASH3P TFIP11 CHD4 SSH2 SIPA1L1 WASHC1 VDAC2	3.61e-04	1189	32	8	GO:0044087
GeneOntologyBiologicalProcess	dendritic cell antigen processing and presentation	WASH3P WASHC1	4.81e-04	21	32	2	GO:0002468
GeneOntologyBiologicalProcess	endosome to plasma membrane protein transport	WASH3P WASHC1	6.30e-04	24	32	2	GO:0099638
GeneOntologyBiologicalProcess	sexual reproduction	CYLC1 SPATA33 WASH3P SSH2 CFAP97 GLRB WASHC1 VDAC2	6.98e-04	1312	32	8	GO:0019953
GeneOntologyBiologicalProcess	meiotic spindle assembly	WASH3P WASHC1	8.60e-04	28	32	2	GO:0090306
GeneOntologyBiologicalProcess	positive regulation of protein localization to cell surface	WASH3P WASHC1	9.22e-04	29	32	2	GO:2000010
GeneOntologyBiologicalProcess	regulation of Arp2/3 complex-mediated actin nucleation	WASH3P WASHC1	1.05e-03	31	32	2	GO:0034315
GeneOntologyBiologicalProcess	actin cytoskeleton organization	WASH3P SSH2 PARVG IQGAP2 SIPA1L1 WASHC1	1.30e-03	803	32	6	GO:0030036
GeneOntologyBiologicalProcess	meiotic spindle organization	WASH3P WASHC1	1.50e-03	37	32	2	GO:0000212
GeneOntologyBiologicalProcess	positive regulation of sterol transport	WASH3P WASHC1	1.75e-03	40	32	2	GO:0032373
GeneOntologyBiologicalProcess	positive regulation of cholesterol transport	WASH3P WASHC1	1.75e-03	40	32	2	GO:0032376
GeneOntologyBiologicalProcess	regulation of actin filament polymerization	WASH3P SSH2 WASHC1	1.79e-03	156	32	3	GO:0030833
GeneOntologyBiologicalProcess	regulation of actin nucleation	WASH3P WASHC1	1.84e-03	41	32	2	GO:0051125
GeneOntologyBiologicalProcess	low-density lipoprotein particle clearance	WASH3P WASHC1	1.84e-03	41	32	2	GO:0034383
GeneOntologyBiologicalProcess	regulation of cytoskeleton organization	NAV3 WASH3P SSH2 IQGAP2 WASHC1	1.84e-03	579	32	5	GO:0051493
GeneOntologyBiologicalProcess	nuclear chromosome segregation	NUSAP1 SMARCC2 WASH3P WASHC1	2.14e-03	356	32	4	GO:0098813
GeneOntologyBiologicalProcess	negative regulation of protein-containing complex assembly	TFIP11 SSH2 VDAC2	2.41e-03	173	32	3	GO:0031333
GeneOntologyBiologicalProcess	oocyte maturation	WASH3P WASHC1	2.41e-03	47	32	2	GO:0001556
GeneOntologyBiologicalProcess	cellular component disassembly	NAV3 SMARCC2 SPATA33 TFIP11 WASHC1	2.43e-03	617	32	5	GO:0022411
GeneOntologyBiologicalProcess	actin filament-based process	WASH3P SSH2 PARVG IQGAP2 SIPA1L1 WASHC1	2.48e-03	912	32	6	GO:0030029
GeneOntologyBiologicalProcess	regulation of actin polymerization or depolymerization	WASH3P SSH2 WASHC1	2.57e-03	177	32	3	GO:0008064
GeneOntologyBiologicalProcess	regulation of actin filament length	WASH3P SSH2 WASHC1	2.69e-03	180	32	3	GO:0030832
GeneOntologyBiologicalProcess	regulation of actin cytoskeleton organization	WASH3P SSH2 IQGAP2 WASHC1	2.82e-03	384	32	4	GO:0032956
GeneOntologyBiologicalProcess	regulation of protein localization to cell surface	WASH3P WASHC1	2.84e-03	51	32	2	GO:2000008
GeneOntologyBiologicalProcess	female meiotic nuclear division	WASH3P WASHC1	2.95e-03	52	32	2	GO:0007143
GeneOntologyBiologicalProcess	actin filament polymerization	WASH3P SSH2 WASHC1	3.14e-03	190	32	3	GO:0030041
GeneOntologyCellularComponent	exocyst	WASH3P TNFAIP2 WASHC1	5.12e-06	21	34	3	GO:0000145
GeneOntologyCellularComponent	vesicle tethering complex	WASH3P TNFAIP2 WASHC1	2.17e-04	72	34	3	GO:0099023
GeneOntologyCellularComponent	WASH complex	WASH3P WASHC1	2.66e-04	15	34	2	GO:0071203
GeneOntologyCellularComponent	BLOC-1 complex	WASH3P WASHC1	3.87e-04	18	34	2	GO:0031083
GeneOntologyCellularComponent	BLOC complex	WASH3P WASHC1	6.36e-04	23	34	2	GO:0031082
GeneOntologyCellularComponent	filopodium	WASH3P IQGAP2 WASHC1	1.04e-03	123	34	3	GO:0030175
Domain	CH	NAV3 PARVG IQGAP2	2.04e-04	65	33	3	SM00033
Domain	CH	NAV3 PARVG IQGAP2	2.54e-04	70	33	3	PF00307
Domain	-	NAV3 PARVG IQGAP2	2.65e-04	71	33	3	1.10.418.10
Domain	CH	NAV3 PARVG IQGAP2	2.87e-04	73	33	3	PS50021
Domain	CH-domain	NAV3 PARVG IQGAP2	3.11e-04	75	33	3	IPR001715
Domain	WH2	WASH2P WASHC1	8.15e-04	24	33	2	PS51082
Domain	CHROMO	SMARCC2 CHD4	1.54e-03	33	33	2	SM00298
Domain	Chromo/shadow_dom	SMARCC2 CHD4	1.54e-03	33	33	2	IPR000953
Domain	-	SMARCC2 CASP8AP2 SSH2	1.34e-02	283	33	3	1.10.10.60
Pubmed	Transcription factor Foxp3 and its protein partners form a complex regulatory network.	NUSAP1 SMARCC2 TFIP11 CHD4 RBBP5 PRRC2A GTF3C5 SIPA1L1	2.79e-09	370	35	8	22922362
Pubmed	Characterization of the murine orthologue of a novel human subtelomeric multigene family.	WASH3P WASH2P WASHC1	9.32e-09	5	35	3	11701968
Pubmed	Human subtelomeric WASH genes encode a new subclass of the WASP family.	WASH3P WASH2P WASHC1	1.86e-08	6	35	3	18159949
Pubmed	Differentially regulated and evolved genes in the fully sequenced Xq/Yq pseudoautosomal region.	WASH3P WASH2P WASHC1	5.21e-08	8	35	3	10655549
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	DNAJC9 SMARCC2 CHD4 SSH2 PEX5L IQGAP2 PRRC2A SIPA1L1 HECTD4	3.41e-07	963	35	9	28671696
Pubmed	WASH and the Arp2/3 complex regulate endosome shape and trafficking.	WASH3P WASHC1	9.84e-07	2	35	2	20175130
Pubmed	WASH Regulates Glucose Homeostasis by Facilitating Glut2 Receptor Recycling in Pancreatic β-Cells.	WASH3P WASHC1	2.95e-06	3	35	2	30425062
Pubmed	WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner.	WASH3P WASHC1	2.95e-06	3	35	2	25225459
Pubmed	SPATA33 is an autophagy mediator for cargo selectivity in germline mitophagy.	SPATA33 VDAC2	2.95e-06	3	35	2	33087875
Pubmed	Changes in bile acid composition are correlated with reduced intestinal cholesterol uptake in intestine-specific WASH-deficient mice.	WASH3P WASHC1	2.95e-06	3	35	2	38086439
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	DNAJC9 SMG1 SMARCC2 CHD4 RBBP5 HECTD4	4.71e-06	440	35	6	34244565
Pubmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.	DNAJC9 NUSAP1 SMARCC2 CHD4 RBBP5 PRRC2A GTF3C5 WASHC1 VDAC2	5.04e-06	1335	35	9	29229926
Pubmed	Trafficking defects in WASH-knockout fibroblasts originate from collapsed endosomal and lysosomal networks.	WASH3P WASHC1	5.90e-06	4	35	2	22718907
Pubmed	The hepatic WASH complex is required for efficient plasma LDL and HDL cholesterol clearance.	WASH3P WASHC1	5.90e-06	4	35	2	31167970
Pubmed	Dendritic cells utilize the evolutionarily conserved WASH and retromer complexes to promote MHCII recycling and helper T cell priming.	WASH3P WASHC1	5.90e-06	4	35	2	24886983
Pubmed	WASH knockout T cells demonstrate defective receptor trafficking, proliferation, and effector function.	WASH3P WASHC1	5.90e-06	4	35	2	23275443
Pubmed	Loss of MAGEL2 in Prader-Willi syndrome leads to decreased secretory granule and neuropeptide production.	WASH3P WASHC1	5.90e-06	4	35	2	32879135
Pubmed	Inactivation of Rho GTPases by Burkholderia cenocepacia Induces a WASH-Mediated Actin Polymerization that Delays Phagosome Maturation.	WASH3P WASHC1	5.90e-06	4	35	2	32492429
Pubmed	BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.	DNAJC9 CHD4 RBBP5 PRRC2A GTF3C5 APOOL VDAC2	5.92e-06	711	35	7	33022573
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	DNAJC9 NUSAP1 SMARCC2 CASP8AP2 CHD4 RBBP5 GTF3C5 VDAC2	5.94e-06	1014	35	8	32416067
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	DNAJC9 NUSAP1 SMARCC2 TFIP11 CHD4 IQGAP2 PRRC2A GTF3C5 VDAC2	6.25e-06	1371	35	9	36244648
Pubmed	Human transcription factor protein interaction networks.	NUSAP1 SMG1 SMARCC2 TFIP11 RBBP5 CCDC174 PRRC2A VDAC2 ZNF503	8.73e-06	1429	35	9	35140242
Pubmed	Endosomal WASH and exocyst complexes control exocytosis of MT1-MMP at invadopodia.	WASH3P WASHC1	9.82e-06	5	35	2	24344185
Pubmed	Functional characterization of Wiskott-Aldrich syndrome protein and scar homolog (WASH), a bi-modular nucleation-promoting factor able to interact with biogenesis of lysosome-related organelle subunit 2 (BLOS2) and gamma-tubulin.	WASH3P WASHC1	9.82e-06	5	35	2	20308062
Pubmed	WASH complex regulates Arp2/3 complex for actin-based polar body extrusion in mouse oocytes.	WASH3P WASHC1	1.47e-05	6	35	2	24998208
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	DNAJC9 SMARCC2 TFIP11 CHD4 RBBP5 PRRC2A GTF3C5	1.84e-05	847	35	7	35850772
Pubmed	WASH maintains NKp46+ ILC3 cells by promoting AHR expression.	WASH3P WASHC1	2.06e-05	7	35	2	28589939
Pubmed	The Proteome of BLOC-1 Genetic Defects Identifies the Arp2/3 Actin Polymerization Complex to Function Downstream of the Schizophrenia Susceptibility Factor Dysbindin at the Synapse.	WASH3P WASHC1	2.74e-05	8	35	2	27927957
Pubmed	A FAM21-containing WASH complex regulates retromer-dependent sorting.	WASH3P WASHC1	2.74e-05	8	35	2	19922874
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	DNAJC9 NUSAP1 SMARCC2 CHD4 RBBP5 GTF3C5	2.94e-05	608	35	6	36089195
Pubmed	Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event.	DNAJC9 SMARCC2 CHD4 PRRC2A	3.35e-05	182	35	4	26527279
Pubmed	RNF2 is recruited by WASH to ubiquitinate AMBRA1 leading to downregulation of autophagy.	WASH3P WASHC1	3.53e-05	9	35	2	24980959
Pubmed	SPATA33 localizes calcineurin to the mitochondria and regulates sperm motility in mice.	SPATA33 VDAC2	3.53e-05	9	35	2	34446558
Pubmed	Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination.	WASH3P WASHC1	4.40e-05	10	35	2	23452853
Pubmed	WASH inhibits autophagy through suppression of Beclin 1 ubiquitination.	WASH3P WASHC1	4.40e-05	10	35	2	23974797
Pubmed	CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL.	WASH3P WASHC1	5.38e-05	11	35	2	26965651
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	SMG1 TFIP11 RBBP5 SIPA1L1 VDAC2	5.39e-05	410	35	5	26949251
Pubmed	Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour.	WASH3P WASHC1	6.45e-05	12	35	2	27390154
Pubmed	The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex.	WASH3P WASHC1	6.45e-05	12	35	2	19922875
Pubmed	Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.	NAV3 DNAJC9 NUSAP1 TFIP11 GTF3C5 SIPA1L1	8.21e-05	732	35	6	34732716
Pubmed	Comprehensive identification of phosphorylation sites in postsynaptic density preparations.	SMARCC2 PEX5L PRRC2A SIPA1L1	8.45e-05	231	35	4	16452087
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	SMARCC2 TFIP11 CHD4 GTF3C5 APOOL VDAC2 HECTD4	8.68e-05	1082	35	7	38697112
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	DNAJC9 NUSAP1 SMARCC2 CHD4 CCDC174 PRRC2A ZNF503	9.78e-05	1103	35	7	34189442
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	DNAJC9 NUSAP1 CHD4 IQGAP2 PRRC2A GTF3C5	1.00e-04	759	35	6	35915203
Pubmed	Parkin mediates the ubiquitination of VPS35 and modulates retromer-dependent endosomal sorting.	WASH3P WASHC1	1.02e-04	15	35	2	29893854
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	NAV3 WASH3P PRRC2A SIPA1L1 WASHC1	1.08e-04	475	35	5	31040226
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	DNAJC9 TFIP11 CHD4 RBBP5	1.16e-04	251	35	4	31076518
Pubmed	The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.	DNAJC9 NUSAP1 CHD4 PRRC2A GTF3C5	1.16e-04	483	35	5	36912080
Pubmed	Identification of Human Neuronal Protein Complexes Reveals Biochemical Activities and Convergent Mechanisms of Action in Autism Spectrum Disorders.	CHD4 PRRC2A VDAC2	1.45e-04	101	35	3	26949739
Pubmed	Heterogeneous nuclear ribonucleoprotein C1/C2, MeCP1, and SWI/SNF form a chromatin remodeling complex at the beta-globin locus control region.	SMARCC2 CHD4	1.49e-04	18	35	2	16217013
Pubmed	TRIM28 interacts with EZH2 and SWI/SNF to activate genes that promote mammosphere formation.	SMARCC2 CHD4	1.49e-04	18	35	2	28068325
Pubmed	Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.	SMARCC2 TFIP11 CHD4 VDAC2	1.56e-04	271	35	4	32433965
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SMG1 CASP8AP2 SFI1 CFAP97 HECTD4	1.78e-04	529	35	5	14621295
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	DNAJC9 SMARCC2 CHD4 IQGAP2 RBBP5 GTF3C5	1.94e-04	857	35	6	25609649
Pubmed	Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1.	SMARCC2 CHD4 GTF3C5	2.19e-04	116	35	3	21549307
Pubmed	Diverse fates of paralogs following segmental duplication of telomeric genes.	WASH2P WASHC1	2.24e-04	22	35	2	15233989
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	NAV3 TFIP11 CHD4 ACAD8 PRRC2A SIPA1L1 HECTD4	2.51e-04	1285	35	7	35914814
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	DNAJC9 NUSAP1 CASP8AP2 TFIP11 CHD4 RBBP5 GTF3C5	2.62e-04	1294	35	7	30804502
Pubmed	Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy.	LY75 PRRC2A	2.68e-04	24	35	2	21323541
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	SMARCC2 CHD4 SFI1 TNFAIP2 RBBP5	2.76e-04	582	35	5	20467437
Pubmed	Transferrin Receptor Protein 1 Cooperates with mGluR2 To Mediate the Internalization of Rabies Virus and SARS-CoV-2.	DNAJC9 SMARCC2 PRRC2A VDAC2	3.42e-04	333	35	4	36779763
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	SMARCC2 TFIP11 CHD4 CCDC174 PRRC2A VDAC2	3.45e-04	954	35	6	36373674
Pubmed	MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.	TFIP11 CHD4 CCDC174 GTF3C5	3.66e-04	339	35	4	30415952
Pubmed	PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.	DNAJC9 SMARCC2 CHD4 PRRC2A	3.70e-04	340	35	4	24332808
Pubmed	RNF138 inhibits late inflammatory gene transcription through degradation of SMARCC1 of the SWI/SNF complex.	SMARCC2 CHD4	3.93e-04	29	35	2	36800290
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	DNAJC9 NUSAP1 SMARCC2 TFIP11 CHD4 VDAC2	4.17e-04	989	35	6	36424410
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	SMG1 TFIP11 TNFAIP2 RBBP5 RGS3	4.58e-04	650	35	5	38777146
Pubmed	A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.	NAV3 CHD4	4.79e-04	32	35	2	23049088
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	SMG1 CHD4 IQGAP2 RBBP5 PRRC2A SIPA1L1 VDAC2	4.99e-04	1440	35	7	30833792
Pubmed	Reevaluating human gene annotation: a second-generation analysis of chromosome 22.	TFIP11 PARVG	5.09e-04	33	35	2	12529303
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	DNAJC9 NUSAP1 TFIP11 RBBP5 PRRC2A SIPA1L1 VDAC2	6.29e-04	1497	35	7	31527615
Pubmed	An Oct4-centered protein interaction network in embryonic stem cells.	SMARCC2 CHD4 RBBP5	6.36e-04	167	35	3	20362541
Pubmed	Analysis of the SWI/SNF chromatin-remodeling complex during early heart development and BAF250a repression cardiac gene transcription during P19 cell differentiation.	SMARCC2 CHD4	6.41e-04	37	35	2	24335282
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	DNAJC9 SMARCC2 RBBP5 PRRC2A	6.43e-04	394	35	4	27248496
Pubmed	ATG5 is required for B cell polarization and presentation of particulate antigens.	DNAJC9 SMARCC2 PRRC2A APOOL VDAC2	6.45e-04	701	35	5	30196744
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	DNAJC9 CHD4 IQGAP2 RBBP5 GTF3C5	6.58e-04	704	35	5	29955894
Pubmed	Identification and Functional Characterization of a Novel Androgen Receptor Coregulator, EAP1.	SMARCC2 CHD4	7.49e-04	40	35	2	34585037
Pubmed	Prohibitin 1 regulates tumor cell apoptosis via the interaction with X-linked inhibitor of apoptosis protein.	DNAJC9 NUSAP1 PRRC2A GTF3C5 VDAC2	7.51e-04	725	35	5	27025967
Pubmed	Identification of Novel Nuclear Factor of Activated T Cell (NFAT)-associated Proteins in T Cells.	SMARCC2 CHD4 GTF3C5	7.65e-04	178	35	3	27637333
Pubmed	Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates.	CASP8AP2 CHD4	7.87e-04	41	35	2	15561718
Pubmed	Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation.	DNAJC9 SMARCC2 CHD4	7.90e-04	180	35	3	30110629
Pubmed	The conserved Tpk1 regulates non-homologous end joining double-strand break repair by phosphorylation of Nej1, a homolog of the human XLF.	TFIP11 CHD4	8.26e-04	42	35	2	34244791
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	NUSAP1 SMARCC2 TFIP11 ACAD8 GTF3C5 CFAP97	9.41e-04	1155	35	6	20360068
Pubmed	In vitro nuclear interactome of the HIV-1 Tat protein.	SMARCC2 CHD4 GTF3C5	9.95e-04	195	35	3	19454010
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	SMARCC2 TFIP11 CHD4 PRRC2A SIPA1L1	1.01e-03	774	35	5	15302935
Interaction	FOXP3 interactions	NUSAP1 SMARCC2 TFIP11 CHD4 RBBP5 PRRC2A GTF3C5 SIPA1L1	5.92e-07	432	35	8	int:FOXP3
Interaction	PRP4K interactions	DNAJC9 SMARCC2 TFIP11 CHD4 RBBP5 PRRC2A	1.97e-05	329	35	6	int:PRP4K
Cytoband	Xq21.1	CYLC1 APOOL	2.94e-04	33	35	2	Xq21.1
Cytoband	10q22.2	DNAJC9 ZNF503	4.54e-04	41	35	2	10q22.2
Cytoband	Ensembl 112 genes in cytogenetic band chr10q22	DNAJC9 VDAC2 ZNF503	5.39e-04	208	35	3	chr10q22
GeneFamily	Wiskott-Aldrich Syndrome protein family	WASH3P WASH2P WASHC1	7.49e-07	16	21	3	14
GeneFamily	PDZ domain containing	RGS3 SIPA1L1	1.33e-02	152	21	2	1220
Disease	tea consumption measurement	RGS3 VDAC2 HECTD4	3.35e-04	129	31	3	EFO_0010091
Disease	coffee consumption	VDAC2 HECTD4	5.20e-04	32	31	2	EFO_0004330
Disease	cups of coffee per day measurement	VDAC2 HECTD4	8.13e-04	40	31	2	EFO_0006782
Disease	aspartate aminotransferase measurement	LY75 IQGAP2 RBBP5 PRRC2A HECTD4	2.34e-03	904	31	5	EFO_0004736
Disease	R-warfarin measurement	SMG1 IQGAP2 RGS3	2.67e-03	265	31	3	EFO_0803324
Disease	carnitine measurement	ACAD8 PEX5L	2.90e-03	76	31	2	EFO_0010469
Disease	pathological myopia	NAV3 CHD4	6.07e-03	111	31	2	EFO_0004207
Disease	endometrial carcinoma	NAV3 CASP8AP2	6.29e-03	113	31	2	EFO_1001512

Protein segments in the cluster

Peptide	Gene	Start	Entry
DGKKYHVKSKSAKPS	CFAP97	141	Q9P2B7
EKGTPGLSFGKKEKK	ACAD8	221	Q9UKU7
YGKGEPKTESKSSKF	CASP8AP2	291	Q9UKL3
KGGKKKYLPPTSRKD	PARVG	26	Q9HBI0
SPSKGKSYTGLGKKS	RGS3	496	P49796
KYKYLVKSKKGSPGL	PEX5L	426	Q8IYB4
SSFKQAFGKKKSTKP	NAV3	1711	Q8IVL0
PLKKDSKKKGGSYAT	CYLC1	126	P35663
SKKKGGSYATNPESK	CYLC1	131	P35663
KDGAICYKPTKSKKL	LY75	1506	O60449
SSKKGKGKKKQYLCP	GLRB	26	P48167
KKSLYTDESSKPGKN	NUSAP1	161	Q9BXS6
GVPKPKFDKSKYSKA	HECTD4	3321	Q9Y4D8
KGKEKDSPFKPKLYK	RBBP5	491	Q15291
KYCKSSKGGGKKSAL	DNAJC9	241	Q8WXX5
KDSGVFGKPKTTNKK	CCDC174	36	Q6PII3
RKKKKKGSPYGSAEA	DCBLD1	481	Q8N8Z6
EGSDYTPGKKKKKKL	CHD4	106	Q14839
KGSKFKKITYPLGLA	APOOL	131	Q6UXV4
GAVKKPYSAKTLSNK	SFI1	36	A8K8P3
KGAKRAKPVKYTAAK	IQGAP2	1471	Q13576
KPKKLLFLGSDGKSY	SMG1	2136	Q96Q15
GPTAKGKDGKKYSSL	PRRC2A	6	P48634
SLASKKKEKSKPYPG	SIPA1L1	836	O43166
KGTPKSSKPGKKHRY	SLCO6A1	36	Q86UG4
AKKKNAKKGPSTPYT	SMARCC2	311	Q8TAQ2
KKGSTYSVPKSKEKL	SPATA33	16	Q96N06
VFTKGKKKKGQPSSA	TNFAIP2	46	Q03169
KEPEMSKGKGKYSGS	SSH2	926	Q76I76
GSKKAIKVFSSAKYP	WASH2P	81	Q6VEQ5
GSKKAIKVFSSAKYP	WASHC1	81	A8K0Z3
PNTGKKSGKIKSSYK	VDAC2	116	P45880
GSKKAIKVFSSAKYP	WASH3P	81	C4AMC7
DKSSFKPYSKPGSDK	ZNF503	171	Q96F45
SGARKPASSKYKLKD	GTF3C5	376	Q9Y5Q8
RKDPSGSKKKPKYSY	TFIP11	226	Q9UBB9