Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionG protein-coupled photoreceptor activity

OPN1MW2 OPN1LW OPN1MW3 OPN1MW

2.75e-0815444GO:0008020
GeneOntologyMolecularFunctionphotoreceptor activity

OPN1MW2 OPN1LW OPN1MW3 OPN1MW

4.78e-0817444GO:0009881
GeneOntologyBiologicalProcessphototransduction

PITPNM1 OPN1MW2 OPN1LW OPN1MW3 OPN1MW

8.25e-0853435GO:0007602
GeneOntologyBiologicalProcessvisual perception

OPN1MW2 OPN1LW OPN1MW3 GPRC5C OPN1MW TIMP3 RABGGTB

4.48e-07230437GO:0007601
GeneOntologyBiologicalProcesssensory perception of light stimulus

OPN1MW2 OPN1LW OPN1MW3 GPRC5C OPN1MW TIMP3 RABGGTB

4.89e-07233437GO:0050953
GeneOntologyBiologicalProcessdetection of light stimulus

PITPNM1 OPN1MW2 OPN1LW OPN1MW3 OPN1MW

5.48e-0777435GO:0009583
GeneOntologyBiologicalProcessdetection of external stimulus

PITPNM1 OPN1MW2 OPN1LW KCNQ1 OPN1MW3 OPN1MW

1.50e-06173436GO:0009581
GeneOntologyBiologicalProcessdetection of abiotic stimulus

PITPNM1 OPN1MW2 OPN1LW KCNQ1 OPN1MW3 OPN1MW

1.61e-06175436GO:0009582
GeneOntologyBiologicalProcessdetection of visible light

OPN1MW2 OPN1LW OPN1MW3 OPN1MW

5.97e-0657434GO:0009584
GeneOntologyBiologicalProcessresponse to light stimulus

PITPNM1 OPN1MW2 OPN1LW OPN1MW3 OPN1MW MYO15A

1.33e-04382436GO:0009416
GeneOntologyBiologicalProcesscellular response to light stimulus

OPN1MW2 OPN1LW OPN1MW3 OPN1MW

1.54e-04130434GO:0071482
GeneOntologyBiologicalProcesspositive regulation of cytokinesis

OPN1MW2 OPN1LW OPN1MW

2.05e-0455433GO:0032467
GeneOntologyBiologicalProcessglycerolipid metabolic process

PITPNM1 ABHD3 PIGQ LMF1 CHKA NOTUM

2.48e-04429436GO:0046486
GeneOntologyBiologicalProcesssensory perception

OPN1MW2 OPN1LW KCNQ1 OPN1MW3 GPRC5C OPN1MW MYO15A TIMP3 RABGGTB

3.04e-041072439GO:0007600
GeneOntologyBiologicalProcessglycerophospholipid metabolic process

PITPNM1 ABHD3 PIGQ CHKA NOTUM

5.17e-04320435GO:0006650
GeneOntologyBiologicalProcessresponse to radiation

PITPNM1 OPN1MW2 OPN1LW OPN1MW3 OPN1MW MYO15A

5.79e-04503436GO:0009314
GeneOntologyBiologicalProcesslipid transport

PITPNM1 KCNQ1 CHKA NOS2 HRH3 TRPC5

5.97e-04506436GO:0006869
GeneOntologyCellularComponentphotoreceptor disc membrane

OPN1MW2 OPN1LW OPN1MW3 OPN1MW

2.47e-0726444GO:0097381
GeneOntologyCellularComponentphotoreceptor outer segment

OPN1MW2 OPN1LW OPN1MW3 OPN1MW

8.68e-05111444GO:0001750
GeneOntologyCellularComponentphotoreceptor cell cilium

OPN1MW2 OPN1LW OPN1MW3 OPN1MW

2.07e-04139444GO:0097733
GeneOntologyCellularComponent9+0 non-motile cilium

OPN1MW2 OPN1LW OPN1MW3 OPN1MW

2.98e-04153444GO:0097731
GeneOntologyCellularComponentnon-motile cilium

OPN1MW2 OPN1LW OPN1MW3 OPN1MW

7.59e-04196444GO:0097730
HumanPhenoBlue cone monochromacy

OPN1LW OPN1MW

1.18e-052182HP:0007939
HumanPhenoCone monochromacy

OPN1LW OPN1MW

1.18e-052182HP:0011517
HumanPhenoReduced OCT-measured foveal thickness

OPN1LW OPN1MW

3.53e-053182HP:0030619
HumanPhenoAbnormal retinal morphology on macular OCT

OPN1LW OPN1MW TIMP3

5.47e-0522183HP:0030612
HumanPhenoAbnormal optical coherence tomography

OPN1LW OPN1MW TIMP3

5.47e-0522183HP:0030603
HumanPhenoAbnormal OCT-measured foveal thickness

OPN1LW OPN1MW

7.05e-054182HP:0030617
DomainOpsin_red/grn

OPN1LW OPN1MW3 OPN1MW

1.14e-083433IPR000378
DomainOPSIN

OPN1LW OPN1MW3 OPN1MW

1.35e-0610433PS00238
DomainOpsin

OPN1LW OPN1MW3 OPN1MW

1.85e-0611433IPR001760
DomainGRAM

TBC1D8 TBC1D9B

6.09e-0416432SM00568
DomainGRAM

TBC1D8 TBC1D9B

1.16e-0322432PF02893
DomainGRAM

TBC1D8 TBC1D9B

1.16e-0322432IPR004182
DomainADAM_spacer1

ADAMTS15 ADAMTSL4

1.27e-0323432IPR010294
DomainADAM_spacer1

ADAMTS15 ADAMTSL4

1.27e-0323432PF05986
PathwayREACTOME_THE_RETINOID_CYCLE_IN_CONES_DAYLIGHT_VISION

OPN1MW2 OPN1LW OPN1MW3

9.24e-078373MM14880
PathwayREACTOME_OPSINS

OPN1MW2 OPN1LW OPN1MW3

1.97e-0610373MM15063
PathwayREACTOME_THE_RETINOID_CYCLE_IN_CONES_DAYLIGHT_VISION

OPN1LW OPN1MW

1.40e-047372M27157
PathwayREACTOME_OPSINS

OPN1LW OPN1MW

2.39e-049372M6285
PathwayREACTOME_RETINOID_CYCLE_DISEASE_EVENTS

OPN1LW OPN1MW

5.13e-0413372M29612
Pubmed

Human L- and M-opsins restore M-cone function in a mouse model for human blue cone monochromacy.

OPN1MW2 OPN1LW OPN1MW3 OPN1MW

2.44e-12445429386880
Pubmed

Molecular genetics of human color vision: the genes encoding blue, green, and red pigments.

OPN1MW2 OPN1LW OPN1MW3 OPN1MW

1.22e-1154542937147
Pubmed

Molecular determinants of human red/green color discrimination.

OPN1MW2 OPN1LW OPN1MW

2.02e-0934538185948
Pubmed

X-linked cone dystrophy caused by mutation of the red and green cone opsins.

OPN1MW2 OPN1LW OPN1MW

2.02e-09345320579627
Pubmed

Expression of red/green-cone opsin mutants K82E, P187S, M273K result in unique pathobiological perturbations to cone structure and function.

OPN1MW2 OPN1LW OPN1MW3

2.02e-09345338410159
Pubmed

Chloride-dependent spectral tuning mechanism of L-group cone visual pigments.

OPN1MW2 OPN1LW OPN1MW3

2.02e-09345323350963
Pubmed

Distinct contributions of rod, cone, and melanopsin photoreceptors to encoding irradiance.

OPN1MW2 OPN1LW OPN1MW3

2.02e-09345320471354
Pubmed

Multiple hypothalamic cell populations encoding distinct visual information.

OPN1MW2 OPN1LW OPN1MW3

2.02e-09345321224225
Pubmed

Circadian Regulation of the Rod Contribution to Mesopic Vision in Mice.

OPN1MW2 OPN1LW OPN1MW3

2.02e-09345336216501
Pubmed

Spectral tuning of a circadian photopigment in a subterranean 'blind' mammal (Spalax ehrenbergi).

OPN1MW2 OPN1LW OPN1MW3

2.02e-09345310567724
Pubmed

Extensive cone-dependent spectral opponency within a discrete zone of the lateral geniculate nucleus supporting mouse color vision.

OPN1MW2 OPN1LW OPN1MW3

2.02e-09345334111401
Pubmed

Genetically engineered mice with an additional class of cone photoreceptors: implications for the evolution of color vision.

OPN1MW2 OPN1LW OPN1MW3

2.02e-09345314500905
Pubmed

Gene-based Therapy in a Mouse Model of Blue Cone Monochromacy.

OPN1MW2 OPN1LW OPN1MW3

2.02e-09345328751656
Pubmed

Rescue of M-cone Function in Aged Opn1mw-/- Mice, a Model for Late-Stage Blue Cone Monochromacy.

OPN1MW2 OPN1LW OPN1MW3

2.02e-09345331469404
Pubmed

The molecular genetics and evolution of red and green color vision in vertebrates.

OPN1MW2 OPN1LW OPN1MW3

2.02e-09345311545071
Pubmed

Mechanisms of spectral tuning in the mouse green cone pigment.

OPN1MW2 OPN1LW OPN1MW3

2.02e-0934539238068
Pubmed

Emergence of novel color vision in mice engineered to express a human cone photopigment.

OPN1MW2 OPN1LW OPN1MW3

2.02e-09345317379811
Pubmed

Co-expression of murine opsins facilitates identifying the site of cone adaptation.

OPN1MW2 OPN1LW OPN1MW3

2.02e-09345312511072
Pubmed

The Pem homeobox gene is X-linked and exclusively expressed in extraembryonic tissues during early murine development.

OPN1MW2 OPN1LW OPN1MW3

2.02e-0934537958444
Pubmed

Visual responses in the dorsal lateral geniculate nucleus at early stages of retinal degeneration in rd1 PDE6β mice.

OPN1MW2 OPN1LW OPN1MW3

8.09e-09445331461375
Pubmed

Murine and bovine blue cone pigment genes: cloning and characterization of two new members of the S family of visual pigments.

OPN1MW2 OPN1LW OPN1MW3

8.09e-0944538088841
Pubmed

Modulation of Fast Narrowband Oscillations in the Mouse Retina and dLGN According to Background Light Intensity.

OPN1MW2 OPN1LW OPN1MW3

8.09e-09445328103478
Pubmed

Molecular biology of the visual pigments.

OPN1MW2 OPN1LW OPN1MW

8.09e-0944533303660
Pubmed

Cones Support Alignment to an Inconsistent World by Suppressing Mouse Circadian Responses to the Blue Colors Associated with Twilight.

OPN1MW2 OPN1LW OPN1MW3

8.09e-09445331846668
Pubmed

Melanopsin-driven increases in maintained activity enhance thalamic visual response reliability across a simulated dawn.

OPN1MW2 OPN1LW OPN1MW3

8.09e-09445326438865
Pubmed

Light/dark translocation of alphatransducin in mouse photoreceptor cells expressing G90D mutant opsin.

OPN1MW2 OPN1LW OPN1MW3

8.09e-09445317249565
Pubmed

Structural and functional rescue of cones carrying the most common cone opsin C203R missense mutation.

OPN1MW2 OPN1LW OPN1MW3

8.09e-09445338060327
Pubmed

Contribution of M-opsin-based color vision to refractive development in mice.

OPN1MW2 OPN1LW OPN1MW3

8.09e-09445334126082
Pubmed

Physiological features of the S- and M-cone photoreceptors of wild-type mice from single-cell recordings.

OPN1MW2 OPN1LW OPN1MW3

8.09e-09445316567464
Pubmed

S-opsin knockout mice with the endogenous M-opsin gene replaced by an L-opsin variant.

OPN1MW2 OPN1LW OPN1MW3

8.09e-09445324801621
Pubmed

Melanopsin Contributions to the Representation of Images in the Early Visual System.

OPN1MW2 OPN1LW OPN1MW3

8.09e-09445328528909
Pubmed

Melanopsin-driven light adaptation in mouse vision.

OPN1MW2 OPN1LW OPN1MW3

8.09e-09445325308073
Pubmed

Noncoding Mutations in a Thyroid Hormone Receptor Gene That Impair Cone Photoreceptor Function.

OPN1MW2 OPN1LW OPN1MW3

2.02e-08545336631163
Pubmed

Using Silent Substitution to Track the Mesopic Transition From Rod- to Cone-Based Vision in Mice.

OPN1MW2 OPN1LW OPN1MW3

2.02e-08545326818794
Pubmed

A common integration locus in type B retrovirus-induced thymic lymphomas.

OPN1MW2 OPN1LW OPN1MW3

2.02e-0854531333116
Pubmed

A distinct contribution of short-wavelength-sensitive cones to light-evoked activity in the mouse pretectal olivary nucleus.

OPN1MW2 OPN1LW OPN1MW3

2.02e-08545322090509
Pubmed

Comparative sequence analysis of the MECP2-locus in human and mouse reveals new transcribed regions.

OPN1MW2 OPN1LW OPN1MW3

2.02e-08545310723722
Pubmed

Peripherin-2 differentially interacts with cone opsins in outer segments of cone photoreceptors.

OPN1MW2 OPN1LW OPN1MW3

2.02e-08545327033727
Pubmed

Melanopsin-based brightness discrimination in mice and humans.

OPN1MW2 OPN1LW OPN1MW3

2.02e-08545322633808
Pubmed

The murine cone photoreceptor: a single cone type expresses both S and M opsins with retinal spatial patterning.

OPN1MW2 OPN1LW OPN1MW3

2.02e-08545311055434
Pubmed

Enhancer/promoter activities of the long/middle wavelength-sensitive opsins of vertebrates mediated by thyroid hormone receptor β2 and COUP-TFII.

OPN1MW2 OPN1LW OPN1MW3

2.02e-08545324058409
Pubmed

Variations in photoreceptor throughput to mouse visual cortex and the unique effects on tuning.

OPN1MW2 OPN1LW OPN1MW3

2.02e-08545334099749
Pubmed

Functional comparison of rod and cone Gα(t) on the regulation of light sensitivity.

OPN1MW2 OPN1LW OPN1MW3

4.04e-08645323288843
Pubmed

Reduced levels of dystrophin associated proteins in the brains of mice deficient for Dp71.

OPN1MW2 OPN1LW OPN1MW3

4.04e-0864538872469
Pubmed

A thyroid hormone receptor that is required for the development of green cone photoreceptors.

OPN1MW2 OPN1LW OPN1MW3

4.04e-08645311138006
Pubmed

Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase.

OPN1MW2 OPN1LW OPN1MW3

4.04e-08645310395695
Pubmed

Transient expression of thyroid hormone nuclear receptor TRbeta2 sets S opsin patterning during cone photoreceptor genesis.

OPN1MW2 OPN1LW OPN1MW3

4.04e-08645317436273
Pubmed

Telomere-related markers for the pseudoautosomal region of the mouse genome.

OPN1MW2 OPN1LW OPN1MW3

4.04e-0864531549575
Pubmed

Retarded developmental expression and patterning of retinal cone opsins in hypothyroid mice.

OPN1MW2 OPN1LW OPN1MW3

7.06e-08745318974269
Pubmed

Genetic and physical mapping of a gene encoding a methyl CpG binding protein, Mecp2, to the mouse X chromosome.

OPN1MW2 OPN1LW OPN1MW3

7.06e-0874538001979
Pubmed

NeuroD1 regulates expression of thyroid hormone receptor 2 and cone opsins in the developing mouse retina.

OPN1MW2 OPN1LW OPN1MW3

7.06e-08745318199774
Pubmed

Mapping of the murine tbl1 gene reveals a new rearrangement between mouse and human X Chromosomes.

OPN1MW2 OPN1LW OPN1MW3

7.06e-0874539880679
Pubmed

Characterization of cDNAs encoding the murine interleukin 2 receptor (IL-2R) gamma chain: chromosomal mapping and tissue specificity of IL-2R gamma chain expression.

OPN1MW2 OPN1LW OPN1MW3

7.06e-0874538378320
Pubmed

Rod Photoreceptor Activation Alone Defines the Release of Dopamine in the Retina.

OPN1MW2 OPN1LW OPN1MW3

7.06e-08745330799247
Pubmed

Activation of the blue opsin gene in cone photoreceptor development by retinoid-related orphan receptor beta.

OPN1MW2 OPN1LW OPN1MW3

7.06e-08745316574740
Pubmed

Rods progressively escape saturation to drive visual responses in daylight conditions.

OPN1MW2 OPN1LW OPN1MW3

7.06e-08745329180667
Pubmed

Cloning and distribution of myosin 3B in the mouse retina: differential distribution in cone outer segments.

OPN1MW2 OPN1LW OPN1MW3

7.06e-08745319332056
Pubmed

Localization of the mdx mutation within the mouse dystrophin gene.

OPN1MW2 OPN1LW OPN1MW3

1.13e-0784532903046
Pubmed

Genetic mapping on the mouse X chromosome of human cDNA clones for the fragile X and Hunter syndromes.

OPN1MW2 OPN1LW OPN1MW3

1.13e-0784531572654
Pubmed

Two transcription factors can direct three photoreceptor outcomes from rod precursor cells in mouse retinal development.

OPN1MW2 OPN1LW OPN1MW3

1.13e-07845321813673
Pubmed

X-chromosome gene order in different Mus species crosses.

OPN1MW2 OPN1LW OPN1MW3

1.13e-0784533416629
Pubmed

The retinitis pigmentosa GTPase regulator (RPGR)- interacting protein: subserving RPGR function and participating in disk morphogenesis.

OPN1MW2 OPN1LW OPN1MW3

1.13e-07845312651948
Pubmed

Transcriptional profiling of murine retinas undergoing semi-synchronous cone photoreceptor differentiation.

OPN1MW2 OPN1LW OPN1MW3

1.13e-07845331163126
Pubmed

Type 3 deiodinase, a thyroid-hormone-inactivating enzyme, controls survival and maturation of cone photoreceptors.

OPN1MW2 OPN1LW OPN1MW3

1.13e-07845320203194
Pubmed

Tubby is required for trafficking G protein-coupled receptors to neuronal cilia.

OPN1MW2 OPN1LW OPN1MW3

1.13e-07845323351594
Pubmed

A retinitis pigmentosa GTPase regulator (RPGR)-deficient mouse model for X-linked retinitis pigmentosa (RP3).

OPN1MW2 OPN1LW OPN1MW3

1.13e-07845310725384
Pubmed

Retinoid X receptor (gamma) is necessary to establish the S-opsin gradient in cone photoreceptors of the developing mouse retina.

OPN1MW2 OPN1LW OPN1MW3

1.13e-07845316043864
Pubmed

Nr2e3 functional domain ablation by CRISPR-Cas9D10A identifies a new isoform and generates retinitis pigmentosa and enhanced S-cone syndrome models.

OPN1MW2 OPN1LW OPN1MW3

1.13e-07845333007388
Pubmed

Linkage of amelogenin (Amel) to the distal portion of the mouse X chromosome.

OPN1MW2 OPN1LW OPN1MW3

1.13e-0784531675194
Pubmed

Retinal dystrophy resulting from ablation of RXR alpha in the mouse retinal pigment epithelium.

OPN1MW2 OPN1LW OPN1MW3

1.69e-07945314742273
Pubmed

Feedback induction of a photoreceptor-specific isoform of retinoid-related orphan nuclear receptor β by the rod transcription factor NRL.

OPN1MW2 OPN1LW OPN1MW3

1.69e-07945325296752
Pubmed

Comparative mapping of the actin-binding protein 280 genes in human and mouse.

OPN1MW2 OPN1LW OPN1MW3

1.69e-0794538088838
Pubmed

ZBED4, a cone and Müller cell protein in human retina, has a different cellular expression in mouse.

OPN1MW2 OPN1LW OPN1MW3

1.69e-07945321850176
Pubmed

Top2b is involved in the formation of outer segment and synapse during late-stage photoreceptor differentiation by controlling key genes of photoreceptor transcriptional regulatory network.

OPN1MW2 OPN1LW OPN1MW3

1.69e-07945328370415
Pubmed

IFT20 is required for opsin trafficking and photoreceptor outer segment development.

OPN1MW2 OPN1LW OPN1MW3

1.69e-07945321307337
Pubmed

Multilocus molecular mapping of the mouse X chromosome.

OPN1MW2 OPN1LW OPN1MW3

1.69e-0794532906327
Pubmed

A visual circuit uses complementary mechanisms to support transient and sustained pupil constriction.

OPN1MW2 OPN1LW OPN1MW3

1.69e-07945327669145
Pubmed

Close linkage of the murine locus bare patches to the X-linked visual pigment gene: implications for mapping human X-linked dominant chondrodysplasia punctata.

OPN1MW2 OPN1LW OPN1MW3

1.69e-0794531973136
Pubmed

Distinct functions of photoreceptor cell-specific nuclear receptor, thyroid hormone receptor beta2 and CRX in one photoreceptor development.

OPN1MW2 OPN1LW OPN1MW3

1.69e-07945312407160
Pubmed

Mapping of ornithine aminotransferase gene sequences to mouse chromosomes 7, X, and 3.

OPN1MW2 OPN1LW OPN1MW3

2.41e-07104531349842
Pubmed

Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin.

OPN1MW2 OPN1LW OPN1MW

2.41e-07104538857542
Pubmed

Linkage of a gene for neural cell adhesion molecule, L1 (CamL1) to the Rsvp region of the mouse X chromosome.

OPN1MW2 OPN1LW OPN1MW3

2.41e-07104531964443
Pubmed

Vax2 regulates retinoic acid distribution and cone opsin expression in the vertebrate eye.

OPN1MW2 OPN1LW OPN1MW3

2.41e-071045321148184
Pubmed

Fam151b, the mouse homologue of C.elegans menorin gene, is essential for retinal function.

OPN1MW2 OPN1LW OPN1MW3

2.41e-071045331949211
Pubmed

Comparative mapping on the mouse and human X chromosomes of a human cDNA clone encoding the vasopressin renal-type receptor (AVP2R).

OPN1MW2 OPN1LW OPN1MW3

2.41e-07104538449515
Pubmed

The nanophthalmos protein TMEM98 inhibits MYRF self-cleavage and is required for eye size specification.

OPN1MW2 OPN1LW OPN1MW3

2.41e-071045332236127
Pubmed

Physical mapping of the loci Gabra3, DXPas8, CamL1, and Rsvp in a region of the mouse X chromosome homologous to human Xq28.

OPN1MW2 OPN1LW OPN1MW3

2.41e-07104531684949
Pubmed

Mapping of the phosphorylase kinase alpha subunit gene on the mouse X chromosome.

OPN1MW2 OPN1LW OPN1MW3

2.41e-07104531973380
Pubmed

Physical linkage of the A-raf-1, properdin, synapsin I, and TIMP genes on the human and mouse X chromosomes.

OPN1MW2 OPN1LW OPN1MW3

3.32e-07114531572636
Pubmed

Mannose supplements induce embryonic lethality and blindness in phosphomannose isomerase hypomorphic mice.

OPN1MW2 OPN1LW OPN1MW3

3.32e-071145324421398
Pubmed

Mapping of the glycine receptor alpha 2-subunit gene and the GABAA alpha 3-subunit gene on the mouse X chromosome.

OPN1MW2 OPN1LW OPN1MW3

4.42e-07124531679744
Pubmed

The spatial patterning of mouse cone opsin expression is regulated by bone morphogenetic protein signaling through downstream effector COUP-TF nuclear receptors.

OPN1MW2 OPN1LW OPN1MW3

4.42e-071245319812316
Pubmed

MAP4K4 is involved in the neuronal development of retinal photoreceptors.

OPN1MW2 OPN1LW OPN1MW3

4.42e-071245337290629
Pubmed

Genetic and physical mapping of the biglycan gene on the mouse X chromosome.

OPN1MW2 OPN1LW OPN1MW3

4.42e-07124538093671
Pubmed

The construction of human somatic cell hybrids containing portions of the mouse X chromosome and their use to generate DNA probes via interspersed repetitive sequence polymerase chain reaction.

OPN1MW2 OPN1LW OPN1MW3

4.42e-07124531916827
Pubmed

Chromosomal localization of GABAA receptor subunit genes: relationship to human genetic disease.

OPN1MW2 OPN1LW OPN1MW3

4.42e-07124532561974
Pubmed

The expression analysis of Sfrs10 and Celf4 during mouse retinal development.

OPN1MW2 OPN1LW OPN1MW3

5.74e-071345323932931
Pubmed

Essential functions of synapsins I and II in synaptic vesicle regulation.

OPN1MW2 OPN1LW OPN1MW3

5.74e-07134537777057
Pubmed

G protein-coupled receptors participate in cytokinesis.

OPN1MW2 OPN1LW OPN1MW

5.74e-071345322888021
Pubmed

Disruption in murine Eml1 perturbs retinal lamination during early development.

OPN1MW2 OPN1LW OPN1MW3

7.29e-071445332221352
CytobandEnsembl 112 genes in cytogenetic band chrXq28

OPN1MW2 OPN1LW OPN1MW3 OPN1MW

5.78e-05213454chrXq28
Cytoband1p31

LEPR RABGGTB

1.95e-04214521p31
CytobandXq28

OPN1MW2 OPN1LW OPN1MW

6.98e-04176453Xq28
Cytoband16p13.3

PIGQ LMF1 NOXO1

1.78e-0324445316p13.3
Cytoband11q13

PITPNM1 CTTN

6.03e-0311845211q13
CytobandEnsembl 112 genes in cytogenetic band chr16p13

PIGQ LMF1 NOXO1

8.44e-03426453chr16p13
CytobandEnsembl 112 genes in cytogenetic band chr2q11

TBC1D8 ZAP70

9.95e-03153452chr2q11
CytobandEnsembl 112 genes in cytogenetic band chr11q13

PITPNM1 CHKA CTTN

1.00e-02454453chr11q13
GeneFamilyOpsin receptors

OPN1MW2 OPN1LW OPN1MW3 OPN1MW

2.64e-0911324215
GeneFamilyWD repeat domain containing|GRAM domain containing|BEACH domain containing

TBC1D8 TBC1D9B

2.34e-04133221146
Drug17-AAG; Up 200; 1uM; MCF7; HT_HG-U133A

ABHD3 C11orf16 LEPR RABGGTB TRPC5

2.28e-051774456943_UP
DrugFluspirilen [1841-19-6]; Up 200; 8.4uM; MCF7; HT_HG-U133A

CDC42BPA KLF6 TIMP3 ADAMTSL4 LEPR

2.28e-051774455008_UP
DrugMethyl benzethonium chloride [25155-18-4]; Up 200; 8.6uM; MCF7; HT_HG-U133A

CDC42BPA C11orf16 KLF6 HRH3 HAPLN1

2.41e-051794456045_UP
DrugCP-320650-01 [172079-28-6]; Up 200; 10uM; MCF7; HT_HG-U133A

ABHD3 LMF1 CELSR3 SP140L RABGGTB

3.28e-051914453905_UP
Drug17-AAG; Down 200; 1uM; MCF7; HG-U133A

GPRC5C CDC42BPA FBXO9 CHKA ADAMTSL4

3.54e-05194445428_DN
DrugClidinium bromide [3485-62-9]; Down 200; 9.2uM; MCF7; HT_HG-U133A

PITPNM1 TBC1D9B CDC42BPA CELSR3 KLF6

3.62e-051954453476_DN
DrugTacrine hydrochloride hydrate [1684-40-8]; Up 200; 15.8uM; MCF7; HT_HG-U133A

GPRC5C CHKA CTTN KLF6 RABGGTB

3.62e-051954455297_UP
DrugPhpc-1,2

OPN1LW OPN1MW

3.64e-055442CID000173570
Drug14-fluororetinal

OPN1LW OPN1MW

3.64e-055442CID006438634
Drug10,20-methanoretinal

OPN1LW OPN1MW

3.64e-055442CID006438558
Drugtrans-retinoyl chloromethane

OPN1LW OPN1MW

3.64e-055442CID006439860
Drug9,11-dcfr

OPN1LW OPN1MW

3.64e-055442CID006443659
DrugTrioxsalen [3902-71-4]; Up 200; 17.6uM; PC3; HT_HG-U133A

PIGQ MYO15A C11orf16 LEPR HAPLN1

3.71e-051964455736_UP
DrugSulfinpyrazone [57-96-5]; Down 200; 9.8uM; MCF7; HT_HG-U133A

LMF1 CELSR3 KLF6 SP140L RABGGTB

3.81e-051974456230_DN
DrugCarbarsone [121-59-5]; Down 200; 15.4uM; MCF7; HT_HG-U133A

ABHD3 ARL1 LMF1 CELSR3 RABGGTB

3.81e-051974453250_DN
Drughaloperidol; Down 200; 10uM; MCF7; HG-U133A

CDC42BPA MYO15A TIMP3 ADAMTSL4 RABGGTB

3.99e-05199445418_DN
Drugrapamycin, Streptomyces hygroscepicus; Up 200; 0.1uM; MCF7; HT_HG-U133A

KCNQ1 CDC42BPA TIMP3 LEPR TRPC5

3.99e-051994455927_UP
Drug3-hydroxyretinal

OPN1LW OPN1MW

5.45e-056442CID000151436
Drug7,8-Dhr

OPN1LW OPN1MW

5.45e-056442CID006443426
DrugAC1NTD7Z

OPN1LW OPN1MW

5.45e-056442CID005378594
Drug5,6-epoxy-3-dehydroretinal

OPN1LW OPN1MW

5.45e-056442CID006449988
Drug4-n-butylaniline

OPN1LW OPN1MW

7.62e-057442CID000007694
Drugtyrphostin 25

KCNQ1 CHKA NOS2 ZAP70

9.02e-05122444CID000002061
DrugAC1L1OQ2

SFMBT1 OPN1MW HRH3

1.10e-0448443CID000032949
Diseaseblue cone monochromacy (implicated_via_orthology)

OPN1MW2 OPN1LW OPN1MW3 OPN1MW

4.72e-124454DOID:0050679 (implicated_via_orthology)
DiseaseCone monochromatism

OPN1LW OPN1MW

2.27e-062452C0339537
DiseaseBLUE CONE MONOCHROMACY

OPN1LW OPN1MW

2.27e-062452303700
DiseaseCone monochromatism

OPN1LW OPN1MW

2.27e-062452cv:C0339537
Diseaseblue cone monochromacy (is_implicated_in)

OPN1LW OPN1MW

2.27e-062452DOID:0050679 (is_implicated_in)
DiseaseBORNHOLM EYE DISEASE

OPN1LW OPN1MW

2.27e-062452C3159311
DiseaseAchromatopsia incomplete, X-linked

OPN1LW OPN1MW

2.27e-062452C2931753
DiseaseRed-green dyschromatopsia

OPN1LW OPN1MW

2.27e-062452cv:C0155016
Diseasenephrotic syndrome type 20 (implicated_via_orthology)

TBC1D8 TBC1D9B

1.36e-054452DOID:0070357 (implicated_via_orthology)
DiseaseOxidative Phosphorylation Deficiencies

FOXRED1 NOS2

8.13e-059452C0949856
DiseaseMitochondrial Respiratory Chain Deficiencies

FOXRED1 NOS2

8.13e-059452C0949857
DiseaseElectron Transport Chain Deficiencies, Mitochondrial

FOXRED1 NOS2

8.13e-059452C0949855
DiseaseHypertensive disease

NOS2 LEPR HRH3 TRPC5

2.02e-04190454C0020538
Diseasequinate measurement

KCNQ1 LEPR

2.36e-0415452EFO_0021167
Diseasehyperglycemia (implicated_via_orthology)

LEPR HRH3

3.05e-0417452DOID:4195 (implicated_via_orthology)
DiseaseAntibody Deficiency Syndrome

ZAP70 LEPR

3.05e-0417452C0003257
Diseaseaspartate aminotransferase measurement

TBC1D8 SRM TBC1D9B CHKA MYO15A ZAP70 LEPR

4.07e-04904457EFO_0004736
DiseaseImmunologic Deficiency Syndromes

ZAP70 LEPR

5.64e-0423452C0021051
DiseaseColitis

TIMP3 NOS2

6.67e-0425452C0009319
DiseaseCone-Rod Dystrophy 2

OPN1LW OPN1MW

8.99e-0429452C3489532
Diseasehypertension (implicated_via_orthology)

KCNQ1 LEPR HRH3

9.90e-04128453DOID:10763 (implicated_via_orthology)
Diseasehyperuricemia

SFMBT1 KCNQ1

1.17e-0333452EFO_0009104

Protein segments in the cluster

PeptideGeneStartEntry
RACSLGPCERTWRWY

ADAMTSL4

901

Q6UY14
GSNWPLRGRKGTYWE

ARSI

306

Q5FYB1
YPTVWCWEGRGQTLL

ABHD3

81

Q8WU67
WDLGGQTSIRPYWRC

ARL1

66

P40616
DGSWAKWDPYGPCSR

ADAMTS15

516

Q8TE58
WSRYWPHGLKTSCGP

OPN1LW

191

P04000
WSRYWPHGLKTSCGP

OPN1MW3

191

P0DN78
WSRYWPHGLKTSCGP

OPN1MW2

191

P0DN77
YRSRGGCPADWIWLV

NOS2

451

P35228
RPWCFYGDARGKVDW

PRSS12

146

P56730
WSAGCRSKYVGLWGR

KCNQ1

176

P51787
CLWLRADAYGPWPRV

MYO15A

1156

Q9UKN7
TEPCVFSGGWLWRFK

JRK

126

O75564
VRCKRLDGLGYWSNW

LEPR

611

P48357
KGGLCRAWNPGRTWS

POM121L12

121

Q8N7R1
WSRYWPHGLKTSCGP

OPN1MW

191

P04001
GAWPALCGRYKRWRK

GPRC5C

226

Q9NQ84
GRPEKLPDVCYSWWV

RABGGTB

231

P53611
GSRRWLLFLEGGWYC

NOTUM

116

Q6P988
WGRSCIKLVPYTSWR

FBXO9

241

Q9UK97
EYRPKGTWAWQGLRA

DSCAML1

1516

Q8TD84
AYLWCKEFLPGAWRG

CHKA

91

P35790
GWFDPWCLLQGLRRK

FOXRED1

216

Q96CU9
LTGRWTFGRGLCKLW

HRH3

96

Q9Y5N1
YDACPKSLRSGVWWP

CELSR3

2126

Q9NYQ7
GKKRGGLWWTYVCSL

GJB5

121

O95377
WKILGYDRCDAGWLA

HAPLN1

296

P10915
EPWLRLCRERGGTFW

PIGQ

91

Q9BRB3
GEWSEPLWCRGGAYL

VMO1

106

Q7Z5L0
KNWRLSVRCGGWPLR

SP140L

351

Q9H930
KGRYGPECDWWSLGV

CDC42BPA

256

Q5VT25
DRGWWLCRYGDRAGL

NOXO1

271

Q8NFA2
SCSYWKGRVPRQGWL

TBC1D9B

161

Q66K14
WRYWKRNGPEPCLGK

C11orf16

386

Q9NQ32
RWWGTKRIDYSLYCP

PITPNM1

831

O00562
GRRYDGSWTWLPKLC

TMEM240

121

Q5SV17
RSAGKWPLKWYAPEC

ZAP70

496

P43403
DDGWWRGVCKGRYGL

CTTN

526

Q14247
CCWKGRVPRQGWLYL

TBC1D8

166

O95759
IREGWFRETCSLWPG

SRM

16

P19623
WCDIRKADLYPIGWC

SFMBT1

96

Q9UHJ3
LATLWYDGFPGWRRK

TRPC5

311

Q9UL62
RQKGGYCSWYRGWAP

TIMP3

186

P35625
YCSWYRGWAPPDKSI

TIMP3

191

P35625
GEKPYRCSWEGCEWR

KLF6

226

Q99612
EGKWWVRKRIGAYFP

LMF1

531

Q96S06