Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
Pubmed

Immunochip identifies novel, and replicates known, genetic risk loci for rheumatoid arthritis in black South Africans.

RBPJ PTPN22

1.91e-06711225014791
Pubmed

Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study.

RBPJ PTPN22

3.27e-06911224449572
Pubmed

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.

RBPJ PTPN22

6.02e-053711220453842
Pubmed

A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.

MCM10 FRA10AC1 JMJD1C

2.59e-0441511316385451
CoexpressionGSE32255_UNSTIM_VS_4H_LPS_STIM_DC_UP

MGAT5 PTPN22 NEB

5.56e-05186113M8914
CoexpressionGSE5542_UNTREATED_VS_IFNA_AND_IFNG_TREATED_EPITHELIAL_CELLS_24H_UP

RBPJ FRA10AC1 PTPN22

6.80e-05199113M6527
CoexpressionWENDT_COHESIN_TARGETS_UP

FRA10AC1 JMJD1C

7.89e-0532112M10024
CoexpressionMA_MYELOID_DIFFERENTIATION_DN

RBPJ PTPN22

1.37e-0442112M1433
CoexpressionMA_MYELOID_DIFFERENTIATION_DN

RBPJ PTPN22

1.43e-0443112MM625
ToppCell356C-Lymphocytic-ILC-ILC-1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

MGAT5 RBPJ PTPN22

1.01e-05180113cedbe692c5257fb6f9a552e2f197163626ac17d9
ToppCellT_cells-Resident_memory_CD8+_T_cells|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis

MGAT5 RBPJ PTPN22

1.05e-05182113111d434b89902ec11fb07f41b8ee1a98f3991b61
ToppCellT_cells-Resident_memory_CD8+_T_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

MGAT5 RBPJ PTPN22

1.08e-05184113e04cabff33a8e36967622ec3e5b37b89afa7e148
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Mesenchymal|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RBPJ JMJD1C NEB

1.29e-051951135c86fddd6d0530beecf45ea5ba6b823123847696
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MGAT5 RBPJ PTPN22

1.33e-05197113c9b1f2ee7eb31a66af331c5aae29e1bbb5186f5a
ToppCellVE-CD4-exh_CD4|VE / Condition, Cell_class and T cell subcluster

MGAT5 RBPJ PTPN22

1.37e-051991136b00a393ad06ae91bf135a54a53ad4de68956193
ToppCellPosterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Calb1-Excitatory_Neuron.Slc17a7-Slc17a6.Calb1-Rorb-Il1rapl2_(Layer_5b)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

IL1RAPL2 NEB

1.70e-0480112402aba070f0728ebda9db7a8fa85441533755ff4
ToppCellFrontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Nptxr-Excitatory_Neuron.Slc17a7.Nptxr-Deptor_(Deep_layer_pyramidal_cells--Layer_5a)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

IL1RAPL2 NEB

3.10e-04108112514dfc3f7ac303311ae599f981f3f3c7eb6801b8
ToppCellsevere_influenza-B_cell|severe_influenza / disease group, cell group and cell class (v2)

MGAT5 GRIN3B

4.34e-0412811292b250186d6bb08ce4f2f5cc4fb93928f6b92d3a
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Tmem163_Dmrtb1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

MAOB IL1RAPL2

4.90e-041361120376c2907b869c7d42f57af7f65ffdd6246c4d27
ToppCellLPS-antiTNF-Lymphocytic_NKT-T_cells-iNKT-MAIT|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PITPNM1 PTPN22

5.19e-04140112a8f3b01d03ee0bf0e752327a98d6b9035930c2b0
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Stem_cells|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

MAOB NEB

5.41e-041431120118772a5bc7c48465e9b314be55203412e8d67c
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Gkn1_Pcdh19|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

IL1RAPL2 MCM10

5.49e-04144112e8caeb6485f4c8f9a3384570dc69024c2bcc9ab0
ToppCell3'_v3-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

JMJD1C PTPN22

5.72e-0414711294998bc40f5c08295cfe3bdcbe43f13b1e564b3d
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_VISp_Col18a1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

IL1RAPL2 NEB

5.80e-04148112fc80c02b51cf55a04ce550838ee2f41d8f656f41
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-3|TCGA-Brain / Sample_Type by Project: Shred V9

RBPJ JMJD1C

5.88e-04149112768877bade04ca0321593b8470b5011ad8270431
ToppCell367C-Lymphocytic-NK_cells-NK_cell_E|367C / Donor, Lineage, Cell class and subclass (all cells)

PITPNM1 NEB

5.88e-04149112f18bddc84b064f3d57a1281d5172c404d87f25da
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Tnc|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

MAOB NEB

6.27e-041541120066b2b8cfc74603e97f271ef5efc7ec512110dc
ToppCellAdult-Immune-dendritic_cell-D122|Adult / Lineage, Cell type, age group and donor

GRIN3B PTPN22

6.27e-0415411264a4686586d08b1e9632dde917b472ac660de2d3
ToppCellnormal_Pleural_Fluid-T/NK_cells-CD4+_Th|normal_Pleural_Fluid / Location, Cell class and cell subclass

MAOB RBPJ

6.68e-04159112ebd840ac2b07e62086ee7b5bb01c21804a0fdc7b
ToppCellPND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_prolif|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PTPN22 NEB

6.77e-041601125cc1b75e3c20d83112b3aa2f3c749a6c73910a2d
ToppCell10x5'-Lung-Lymphocytic_T_CD4/8-lo|Lung / Manually curated celltypes from each tissue

MCM10 PTPN22

6.85e-04161112a1f10e04836848b1deaf295fae033f54d1572fcd
ToppCellfacs-Lung-ENDOMUCIN-18m-Lymphocytic-NK_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MGAT5 PTPN22

6.94e-041621125731f9514434296132df4bc86f78ce87b07cdeca
ToppCellfacs-Lung-ENDOMUCIN-18m-Lymphocytic-Natural_Killer|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MGAT5 PTPN22

6.94e-041621120321fc954ae4ad67ca438cbbc84632562d222188
ToppCellE18.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MCM10 PTPN22

7.02e-041631129c91415a56b12b3b2d15d253bb59db8bedf49ea2
ToppCell3'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PTPN22 NEB

7.02e-04163112ed7319185c1ec384444309bb8be95691a0c2091c
ToppCell3'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PTPN22 NEB

7.02e-04163112e6213900f56257fe38ac7852351bea0340294be0
ToppCellPND10-Immune-Immune_Myeloid-DC-cDC2-cDC2_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MCM10 RBPJ

7.02e-041631127af3d3ae7e0de733a18d0486c7ffbb5a7ef7230a
ToppCellnormal_Pleural_Fluid-Myeloid_cells-Undetermined|Myeloid_cells / Location, Cell class and cell subclass

MAOB MCM10

7.02e-04163112be774c0ba38fa89a9c0076524cf05d593c6c6826
ToppCell3'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PTPN22 NEB

7.02e-04163112ef35d7ff09aa364734fea7fdaab6260c0a3fbf09
ToppCell390C-Lymphocytic-ILC|390C / Donor, Lineage, Cell class and subclass (all cells)

MGAT5 PTPN22

7.11e-04164112b0fc63b72162b5cc4d1e0a271a12f3d3ab29398f
ToppCellnormal_Pleural_Fluid-T/NK_cells-CD4+_Th|T/NK_cells / Location, Cell class and cell subclass

MAOB RBPJ

7.11e-04164112334f376350c9cf92611d0f75b2e18a102f4c116a
ToppCellE18.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PITPNM1 MGAT5

7.19e-041651120c80abf13409767825ef8a507b498afafa7e89c5
ToppCellE18.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PITPNM1 MGAT5

7.19e-04165112cced77f2d74b07010307d7f4788b8cf3fdaeb91a
ToppCelltumor_Lymph_Node_/_Brain-T/NK_cells-Exhausted_Tfh|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

RBPJ PTPN22

7.28e-04166112c73fce59256ad501864f44f76cfae2fc33b3777e
ToppCell5'-GW_trimst-2-LymphNode-Hematopoietic-T_cells-LTi-like_NCR-_ILC3|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MGAT5 PTPN22

7.28e-041661129fae71b0a42a9b2222453c03e0a1e83f30117ae9
ToppCell367C-Lymphocytic-NK_cells-NK_cell_E|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

PITPNM1 NEB

7.37e-04167112b5d15773be32cd277125fd3b4056a8fefaefa5ec
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-Treg-Treg_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PTPN22 NEB

7.37e-04167112eed22d1a17aab84dacb1a488528bae9389644cb9
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c07-TYROBP|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

PTPN22 NEB

7.37e-04167112ded4d6cccd3660662f12cf5a512de31d26325f1b
ToppCellfacs-Lung-18m-Hematologic-lymphocytic-regulatory_T_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PTPN22 NEB

7.46e-041681122d2eab3190374f79f373e31c8b062ff4e1766396
ToppCellfacs-Lung-18m-Hematologic-lymphocytic-regulatory_T_cell-regulatory_T_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PTPN22 NEB

7.46e-04168112df58156721457b34af1e81c0eb8a7243cbbfb303
ToppCell390C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2|390C / Donor, Lineage, Cell class and subclass (all cells)

RBPJ PTPN22

7.54e-04169112cfc9ff103d13a2d5eacc457e800f53fdd29f7738
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MCM10 GRIN3B

7.54e-041691120bc8ef341ce307b19018d4ac8de0a4d04254209d
ToppCell3'-Airway_Nasal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MCM10 NEB

7.63e-04170112db0ec8b7ecbb4db108fc35c564df4b740f65cc8f
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-24m-Lymphocytic-T_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MGAT5 PTPN22

7.63e-041701127040f7b1e4d8d26db787449e557371c5d872c95a
ToppCell3'-Airway_Nasal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MCM10 NEB

7.63e-0417011288f6804e973863245ca1c7e5e6656d4a8b824da9
ToppCell3'-Airway_Nasal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MCM10 NEB

7.63e-04170112dad3aaf7d9f7bafdbddee51610f03f2359e587ae
ToppCelldroplet-Lung-18m-Hematologic-lymphocytic-regulatory_T_cell-regulatory_T_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PTPN22 NEB

7.72e-041711127c0a1b0676f6749ee710c6bdeca6d6f7fac79b69
ToppCelldroplet-Limb_Muscle-nan-18m-Lymphocytic-T_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MGAT5 PTPN22

7.72e-041711124198e7fef1aaee3d85722094f3e444655d393e9e
ToppCelldroplet-Lung-18m-Hematologic-lymphocytic-regulatory_T_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PTPN22 NEB

7.72e-0417111210492832db8ebc3cf85503c441f33bd94df9458e
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MAOB IL1RAPL2

7.72e-041711129e00c8191ca9d52151a49baf39f8581cb176fb76
ToppCelldroplet-Lung-LUNG-30m-Lymphocytic-Regulatory_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPN22 NEB

7.81e-041721123acf35b774ebc0f9e96299d0bd3e9d03bbf6b90c
ToppCelldroplet-Lung-LUNG-30m-Lymphocytic-regulatory_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPN22 NEB

7.81e-041721124d04df9776394ea156ed5822f92ae74fdefbaa3d
ToppCelldroplet-Kidney-KIDNEY-1m-Lymphocytic-nan|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MGAT5 PTPN22

7.90e-04173112de124fb7ded04664d4184bf12f1f201c0784f07c
ToppCell5'-Adult-LymphNode-Hematopoietic-T_cells-TRGV2_gdT|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FRA10AC1 PTPN22

7.90e-0417311279d11f94a8f6a420c18c2fef0da77e9af3204765
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-mature_NK_T_cell-mature_NK_T_cell_l4|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PTPN22 NEB

7.90e-0417311242272af45547422ef85e35f4a4c7d269e9ed7a8a
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MAOB IL1RAPL2

7.90e-041731125aa4d45a01d2d09eff8b4deb32bd91ab2471210a
ToppCellfacs-Lung-EPCAM-18m-Lymphocytic-regulatory_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPN22 NEB

7.90e-0417311213f67f61edb734ff846da92d41e81ec4670a2b66
ToppCellfacs-Lung-EPCAM-18m-Lymphocytic-Regulatory_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPN22 NEB

7.90e-0417311282fa5ff6a00216a21a37fafeaf3e21e964c61d47
ToppCelldroplet-Lung-1m-Hematologic-lymphocytic-regulatory_T_cell-regulatory_T_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PTPN22 NEB

7.99e-0417411233386750842c47ad7e7286d0f26a556da1a2de02
ToppCelldroplet-Lung-1m-Hematologic-lymphocytic-regulatory_T_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PTPN22 NEB

7.99e-041741129344d4e76d7d9429aea87d3c0b98246200d16014
ToppCelldroplet-Kidney-nan-3m-Lymphocytic|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RBPJ PTPN22

7.99e-041741120e541581df2d4249270b28ceded6298329013580
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-mature_NK_T_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PTPN22 NEB

7.99e-041741125c69447261c5aa309a24882656da90655728d637
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c02-GPR183|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

FRA10AC1 JMJD1C

8.09e-04175112f456d8d958b71f7a942b718605712593d9de1bfd
ToppCell3'-GW_trimst-1.5-SmallIntestine-Hematopoietic-T_cells-ILCP|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PITPNM1 PTPN22

8.09e-04175112f2c3e0f728a43d6988e793c8a50c964f7447db82
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_IT|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

IL1RAPL2 MGAT5

8.09e-04175112c227fc5d1ccb69b82a96a6354913cafaf27d0eec
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_VISp_Penk_Fst|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

IL1RAPL2 MGAT5

8.18e-04176112a1b9f8f199a028b3fa85de43fe96bc29f387bfd8
ToppCellfacs-Heart-RV-18m-Lymphocytic-T_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCM10 PTPN22

8.18e-041761123e7647364c13beade9ca278c7ce8e89546e0b060
ToppCellfacs-Heart-RV-18m-Lymphocytic-T_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCM10 PTPN22

8.18e-04176112a55572470de6af6cbf29ed4f785fdca62d24cd23
ToppCelldroplet-Kidney-KIDNEY-1m-Lymphocytic-T_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPN22 NEB

8.27e-0417711236da06ca9577cdb7c7b5114e604f6546b9765c08
ToppCell356C-Lymphocytic-ILC|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

RBPJ PTPN22

8.27e-041771127ddd7d1854ad42abd630ad0c702105102cec93e7
ToppCellfacs-Marrow-T_cells-18m-Lymphocytic-CD4-positive,_alpha-beta_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPN22 NEB

8.36e-0417811243eda32af2e5e28a92421612d0a4c21e5427a772
ToppCellfacs-Marrow-T_cells-18m-Lymphocytic-BM_CD4_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPN22 NEB

8.36e-04178112888add8935ef3aef9b6693c5698e9d1842e66337
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MAOB MGAT5

8.36e-04178112dfed0fbf7a73b8a9e00178ec58dc4592b271c344
ToppCelldroplet-Liver-Npc-18m-Lymphocytic-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RBPJ PTPN22

8.36e-0417811209d2687e0d79f12e90af35fc1c0453d249cf2d19
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PITPNM1 GRIN3B

8.36e-041781123b12db04006db6e94fc45649a4b3a63b92f21a61
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MAOB MGAT5

8.46e-04179112d0fa700648db8ce76a8aa689879a25048299fa40
ToppCell390C-Lymphocytic-ILC-ILC-1|390C / Donor, Lineage, Cell class and subclass (all cells)

RBPJ PTPN22

8.46e-04179112e7045e27f0eb88f552b31c04b56d78e5ccd7a36c
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MAOB MGAT5

8.46e-041791122e49b215b71438400aebb483f2c2c08d5e956961
ToppCellfacs-Liver-Non-hepatocytes-3m-Lymphocytic-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RBPJ PTPN22

8.93e-041841128fc047977fad38fcd26eebcc279a688efd342ed8
ToppCellCV-Severe-3|CV / Virus stimulation, Condition and Cluster

MCM10 RBPJ

8.93e-041841121c9bda00bb6efd98f68781ca06655bf6c4282f27
ToppCelldroplet-Kidney-KIDNEY-1m-Lymphocytic-CD45____T_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPN22 NEB

8.93e-041841122c8e9ddce3e60302965dcf9dee77c4fe33e4071d
ToppCelldroplet-Bladder-BLADDER-1m-Hematologic-nan|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MGAT5 PTPN22

9.03e-04185112969248b63d4ce335f223528de756bcddffadbd77
ToppCellChildren_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

MGAT5 RBPJ

9.03e-041851128207f9eff113eed429e961748c6b17d672a13b33
ToppCellAdult-Immune-interstitial_macrophage_(C1Q_positive)-D175|Adult / Lineage, Cell type, age group and donor

MGAT5 RBPJ

9.03e-04185112ab5704b96f1d368911308797d10c7c52766ab134
ToppCell21-Trachea-Epithelial-Intermediate_ciliated|Trachea / Age, Tissue, Lineage and Cell class

MAOB GRIN3B

9.22e-041871121a2178a195d078d1963947b327c6d0d4f2f48341
ToppCellCV-Severe-3|Severe / Virus stimulation, Condition and Cluster

MCM10 RBPJ

9.22e-0418711268cb43a73945f5e252530da25613f6b3f484b4d5
ToppCell21-Trachea-Epithelial-Neuroendocrine|Trachea / Age, Tissue, Lineage and Cell class

MAOB NEB

9.32e-04188112e78d4f7a5d28c77503cb041ff585d13df4c88bd2
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

MGAT5 JMJD1C

9.42e-04189112b13f315f617840eb5143a4e8a33a657c20365c21
ToppCellT_cells-Effector_memory_CD4+_T_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

MGAT5 RBPJ

9.52e-0419011213dc3a0aaa554f63eabac37726bd1f11b66fb3dd
ToppCellrenal_medulla_nuclei-Adult_normal_reference|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

MGAT5 JMJD1C

9.52e-04190112f1363f7806cfc4f14fbc1b0e8dac2de813a88eee
ToppCellControl-T_cells-CD4+_T_cells|Control / group, cell type (main and fine annotations)

RBPJ PTPN22

9.52e-041901120733be5e54fe15d6d6ea51c154a95258e83f1b92
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_T_CD4/8-lo|lymph-node_spleen / Manually curated celltypes from each tissue

MCM10 PTPN22

9.52e-041901124225bfa10a6fb909a3ba8ac26f3541c390b46737
ToppCellT_cells-Effector_memory_CD4+_T_cells|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis

MGAT5 RBPJ

9.52e-041901121af91fe0ee2c924e12f4db93c793e7af475d8f80
ToppCell3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells-CD8_T_cells_L.1.1.5.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RBPJ PTPN22

9.52e-04190112ce049630ed69d31f00acbc1b5b0896efc592121f
ToppCellChildren_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)|Children_(3_yrs) / Lineage, Cell type, age group and donor

MGAT5 RBPJ

9.52e-04190112f573fef3762a30c38cf8fa7f45df0ffbb49dc873
ToppCelltumor_Lung-T/NK_cells-Exhausted_Tfh|tumor_Lung / Location, Cell class and cell subclass

RBPJ PTPN22

9.62e-041911123e259eba83f8159d1a1a96b98d0e867fe547c5e7
ToppCellCOVID-19-kidney-Proliferating_T_cell|COVID-19 / Disease (COVID-19 only), tissue and cell type

MCM10 PTPN22

9.62e-04191112bae388e0e9447d576e68465d73d8313ef6925ffa
ToppCellmetastatic_Brain-T/NK_cells-Exhausted_CD8+_T|T/NK_cells / Location, Cell class and cell subclass

RBPJ PTPN22

9.62e-041911122ffd40ebf1d63e61a97208ddcbeb6a86e409f9d8
ToppCell15-Trachea-Epithelial-Neuroendocrine|Trachea / Age, Tissue, Lineage and Cell class

MAOB NEB

9.62e-0419111276311fa5f3ae9bb27cf04387a8c92300f2888c28
DrugNSC100058

MAOB MGAT5 GRIN3B

5.34e-0674113CID000003449
Drugbudipine

MAOB GRIN3B

6.33e-0525112CID000068778
DrugPHA-00851261E [724719-49-7]; Down 200; 1uM; MCF7; HT_HG-U133A

PITPNM1 IL1RAPL2 NEB

9.85e-051961133857_DN
DrugTrioxsalen [3902-71-4]; Up 200; 17.6uM; MCF7; HT_HG-U133A

IL1RAPL2 PTPN22 NEB

1.02e-041981136216_UP
DrugSulfinpyrazone [57-96-5]; Up 200; 9.8uM; MCF7; HT_HG-U133A

PITPNM1 IL1RAPL2 NEB

1.02e-041981136230_UP
DrugFlucytosine [2022-85-7]; Down 200; 31uM; HL60; HT_HG-U133A

PITPNM1 IL1RAPL2 NEB

1.03e-041991133073_DN
DrugMethapyrilene hydrochloride [135-23-9]; Up 200; 13.4uM; MCF7; HT_HG-U133A

IL1RAPL2 PTPN22 NEB

1.03e-041991134990_UP
DrugOxalamine citrate salt [1949-20-8]; Down 200; 9.2uM; MCF7; HT_HG-U133A

IL1RAPL2 PTPN22 NEB

1.03e-041991133344_DN
DrugEthoxyquin [91-53-2]; Up 200; 18.4uM; MCF7; HT_HG-U133A

PITPNM1 MAOB PTPN22

1.03e-041991133421_UP
DrugTinidazole [19387-91-8]; Down 200; 16.2uM; MCF7; HT_HG-U133A

PITPNM1 MAOB IL1RAPL2

1.05e-042001133896_DN
Drugheliotrine

MAOB NEB

2.36e-0448112ctd:C010178
DrugI gr

MGAT5 GRIN3B

3.00e-0454112CID006419741
DrugNebeldose

PITPNM1 MAOB

3.70e-0460112CID000165707
Drugsenkirkine

MAOB NEB

3.82e-0461112ctd:C009238
DrugPyrrolizidine Alkaloids

MAOB NEB

4.48e-0466112ctd:D011763
DrugDale

IL1RAPL2 MGAT5

5.18e-0471112CID005486816
DrugAC1O6W2C

RBPJ GRIN3B

5.78e-0475112CID000446591
DrugAcurea

RBPJ GRIN3B

5.78e-0475112CID000003662
Drug7-NI

MAOB GRIN3B

6.25e-0478112CID000001893
DrugAC1L1CLB

MAOB GRIN3B

8.67e-0492112CID000001951
Drugamantadine

MAOB GRIN3B

9.25e-0495112CID000002130
Drugagmatine

MAOB GRIN3B

1.06e-03102112CID000000199
Drugfentanyl

IL1RAPL2 GRIN3B

1.26e-03111112CID000003345
DrugDOPAC

MAOB GRIN3B

1.28e-03112112CID000000547
Diseaseneutrophil count

RBPJ GRIN3B JMJD1C PTPN22

1.21e-031382114EFO_0004833
DiseaseEndometrioma

MAOB RBPJ

1.58e-03161112C0269102
DiseaseEndometriosis

MAOB RBPJ

1.58e-03161112C0014175
Diseaserheumatoid arthritis, anti-citrullinated protein antibody seropositivity, rheumatoid factor seropositivity measurement

RBPJ PTPN22

1.75e-03170112EFO_0000685, EFO_0007791, EFO_0007837
DiseaseRheumatoid Arthritis

RBPJ PTPN22

1.84e-03174112C0003873
Diseasealcohol use disorder (implicated_via_orthology)

RBPJ JMJD1C

2.30e-03195112DOID:1574 (implicated_via_orthology)
Diseaseneutrophil count, eosinophil count

JMJD1C PTPN22

2.73e-03213112EFO_0004833, EFO_0004842
Diseaseneutrophil count, basophil count

JMJD1C PTPN22

3.02e-03224112EFO_0004833, EFO_0005090
Diseaseaspartate aminotransferase to alanine aminotransferase ratio

RBPJ PTPN22

3.42e-03239112EFO_0010934

Protein segments in the cluster

PeptideGeneStartEntry
EYEMGKKKCERYWAE

PTPN22

131

Q9Y2R2
KKKCERYWAEPGEMQ

PTPN22

136

Q9Y2R2
WRKKDYCGTMIIDGE

MAOB

306

P27338
DGYPHCEGKIKWMKD

MGAT5

151

Q09328
RDKELYAWMKCVKGQ

JMJD1C

1881

Q15652
GNKYCDKKEGLKSWE

FRA10AC1

176

Q70Z53
CGLYKWERDGMLKEK

MCM10

836

Q7L590
DLLHDKWYKMVPCGK

GRIN3B

801

O60391
GLRLMWYKNKGDLEE

IL1RAPL2

71

Q9NP60
KLCKVEFRYWGMQAK

PITPNM1

191

O00562
PCVYLMGSGWKKKKE

RBPJ

71

Q06330
KLYREGWDEMKAGCD

NEB

3971

P20929