Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	CK1gamma_C	CSNK1G2 CSNK1G1	1.94e-05	3	48	2	PF12605
Domain	Casein_kinase-1_gamma_C	CSNK1G2 CSNK1G1	1.94e-05	3	48	2	IPR022247
Domain	EGF-like_dom	ITGBL1 EYS MALRD1 PAMR1 ADAM30 VWCE	4.06e-05	249	48	6	IPR000742
Domain	EGF_1	ITGBL1 EYS MALRD1 PAMR1 ADAM30 VWCE	4.64e-05	255	48	6	PS00022
Domain	EGF_2	ITGBL1 EYS MALRD1 PAMR1 ADAM30 VWCE	5.74e-05	265	48	6	PS01186
Domain	VWC	COL5A2 MUC19 VWCE	1.26e-04	38	48	3	SM00214
Domain	VWFC_2	COL5A2 MUC19 VWCE	1.26e-04	38	48	3	PS50184
Domain	VWF_dom	COL5A2 MUC19 VWCE	1.70e-04	42	48	3	IPR001007
Domain	EGF_3	EYS MALRD1 PAMR1 ADAM30 VWCE	3.33e-04	235	48	5	PS50026
Domain	EGF	ITGBL1 EYS MALRD1 PAMR1 VWCE	3.33e-04	235	48	5	SM00181
Domain	EGF-like_CS	EYS MALRD1 PAMR1 ADAM30 VWCE	5.38e-04	261	48	5	IPR013032
Domain	VWC_out	MUC19 VWCE	1.08e-03	19	48	2	SM00215
Domain	zf-C2H2	OVOL1 ZNF560 ZNF280D ZNF268 ZNF561 ZNF682 ZNF687	1.84e-03	693	48	7	PF00096
Domain	VWC	COL5A2 VWCE	2.34e-03	28	48	2	PF00093
Domain	Alkaline_phosphatase_core	ARSF ENPP3	2.87e-03	31	48	2	IPR017850
Domain	Alkaline_Pase-like_a/b/a	ARSF ENPP3	2.87e-03	31	48	2	IPR017849
Domain	-	ARSF ENPP3	2.87e-03	31	48	2	3.40.720.10
Domain	ZINC_FINGER_C2H2_2	OVOL1 ZNF560 ZNF280D ZNF268 ZNF561 ZNF682 ZNF687	3.44e-03	775	48	7	PS50157
Domain	ZINC_FINGER_C2H2_1	OVOL1 ZNF560 ZNF280D ZNF268 ZNF561 ZNF682 ZNF687	3.49e-03	777	48	7	PS00028
Domain	EGF_CA	EYS PAMR1 VWCE	3.80e-03	122	48	3	SM00179
Domain	VWFC_1	COL5A2 VWCE	3.85e-03	36	48	2	PS01208
Domain	EGF-like_Ca-bd_dom	EYS PAMR1 VWCE	3.97e-03	124	48	3	IPR001881
Domain	Znf_C2H2-like	OVOL1 ZNF560 ZNF280D ZNF268 ZNF561 ZNF682 ZNF687	3.99e-03	796	48	7	IPR015880
Domain	EGF	EYS MALRD1 PAMR1	4.16e-03	126	48	3	PF00008
Domain	Znf_C2H2	OVOL1 ZNF560 ZNF280D ZNF268 ZNF561 ZNF682 ZNF687	4.24e-03	805	48	7	IPR007087
Domain	ZnF_C2H2	OVOL1 ZNF560 ZNF280D ZNF268 ZNF561 ZNF682 ZNF687	4.33e-03	808	48	7	SM00355
Pubmed	Common PTP4A1-PHF3-EYS variants are specific for alcohol dependence.	EYS PHF3	6.07e-06	3	50	2	24961364
Pubmed	Association of rare PTP4A1-PHF3-EYS variants with alcohol dependence.	EYS PHF3	6.07e-06	3	50	2	23324950
Pubmed	Necdin regulates p53 acetylation via Sirtuin1 to modulate DNA damage response in cortical neurons.	TUBB3 SIRT1	2.02e-05	5	50	2	18753379
Pubmed	Role for casein kinase 1 in the phosphorylation of Claspin on critical residues necessary for the activation of Chk1.	CSNK1G2 CSNK1G1	2.02e-05	5	50	2	21680713
Pubmed	Lamin B1 protein is required for dendrite development in primary mouse cortical neurons.	TPR TUBB3	5.64e-05	8	50	2	26510501
Pubmed	Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7.	CSNK1G2 CSNK1G1	9.05e-05	10	50	2	25500533
Pubmed	Population-specific regulation of Chmp2b by Lbx1 during onset of synaptogenesis in lateral association interneurons.	TUBB3 LMX1B	1.32e-04	12	50	2	23284619
Pubmed	Expression patterns of developmental control genes in normal and Engrailed-1 mutant mouse spinal cord reveal early diversity in developing interneurons.	TUBB3 LMX1B	1.56e-04	13	50	2	9315901
Pubmed	Delays in neuronal differentiation in Mash1/Ascl1 mutants.	TUBB3 LMX1B	1.82e-04	14	50	2	16677628
Pubmed	Ascl1/Mash1 is required for the development of central serotonergic neurons.	TUBB3 LMX1B	1.82e-04	14	50	2	15133515
Pubmed	Association of CPI-17 with protein kinase C and casein kinase I.	CSNK1G2 CSNK1G1	2.10e-04	15	50	2	15003508
Pubmed	The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age.	TUBB3 LMX1B	2.10e-04	15	50	2	18076286
Pubmed	dILA neurons in the dorsal spinal cord are the product of terminal and non-terminal asymmetric progenitor cell divisions, and require Mash1 for their development.	TUBB3 LMX1B	2.10e-04	15	50	2	16690754
Pubmed	Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner.	TUBB3 LMX1B	2.40e-04	16	50	2	17596284
Pubmed	Wnt antagonism of Shh facilitates midbrain floor plate neurogenesis.	TUBB3 LMX1B	2.40e-04	16	50	2	19122665
Pubmed	Neurogenin 2 is required for the development of ventral midbrain dopaminergic neurons.	TUBB3 LMX1B	2.40e-04	16	50	2	16410412
Pubmed	Delayed dopaminergic neuron differentiation in Lrp6 mutant mice.	TUBB3 LMX1B	2.72e-04	17	50	2	19795519
Pubmed	Dominant inhibition of lens placode formation in mice.	TUBB3 LMX1B	2.72e-04	17	50	2	18778700
Pubmed	Adipocyte arrestin domain-containing 3 protein (Arrdc3) regulates uncoupling protein 1 (Ucp1) expression in white adipose independently of canonical changes in β-adrenergic receptor signaling.	SIRT1 TGS1	2.72e-04	17	50	2	28291835
Pubmed	TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity.	TRIM22 TRIM52	3.05e-04	18	50	2	23077300
Pubmed	BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets.	TUBB3 SIRT1	3.41e-04	19	50	2	23160044
Pubmed	Neurogenin3 restricts serotonergic neuron differentiation to the hindbrain.	TUBB3 LMX1B	3.79e-04	20	50	2	25392491
Pubmed	The transcription factor Uncx4.1 acts in a short window of midbrain dopaminergic neuron differentiation.	TUBB3 LMX1B	3.79e-04	20	50	2	23217170
Pubmed	Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrain.	TUBB3 LMX1B	4.18e-04	21	50	2	19542360
Pubmed	Differences in neurogenic potential in floor plate cells along an anteroposterior location: midbrain dopaminergic neurons originate from mesencephalic floor plate cells.	TUBB3 LMX1B	4.18e-04	21	50	2	17670789
Pubmed	The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.	EYS PAMR1 DBF4B ATP2C2 HHIPL2 ADAM30 LRRC18	4.94e-04	985	50	7	12975309
Pubmed	A unilateral negative feedback loop between miR-200 microRNAs and Sox2/E2F3 controls neural progenitor cell-cycle exit and differentiation.	TUBB3 LMX1B	6.95e-04	27	50	2	22993445
Pubmed	Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells.	TUBB3 LMX1B	9.17e-04	31	50	2	19796621
Pubmed	Wnt1-cre-mediated conditional loss of Dicer results in malformation of the midbrain and cerebellum and failure of neural crest and dopaminergic differentiation in mice.	TUBB3 LMX1B	9.17e-04	31	50	2	20457670
Pubmed	The late and dual origin of cerebrospinal fluid-contacting neurons in the mouse spinal cord.	TUBB3 LMX1B	9.17e-04	31	50	2	26839365
Pubmed	Nuclear pore composition regulates neural stem/progenitor cell differentiation in the mouse embryo.	TPR TUBB3	1.10e-03	34	50	2	18539113
Pubmed	Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease.	TUBB3 LMX1B	1.10e-03	34	50	2	25915474
Pubmed	Smooth Muscle Differentiation Is Essential for Airway Size, Tracheal Cartilage Segmentation, but Dispensable for Epithelial Branching.	TUBB3 ITGBL1	1.10e-03	34	50	2	32142630
Pubmed	BMP/SMAD Pathway Promotes Neurogenesis of Midbrain Dopaminergic Neurons In Vivo and in Human Induced Pluripotent and Neural Stem Cells.	TUBB3 LMX1B	1.38e-03	38	50	2	29321139
Cytoband	6q12	EYS PHF3	2.65e-04	22	50	2	6q12
Cytoband	Ensembl 112 genes in cytogenetic band chr6q12	EYS PHF3	3.72e-04	26	50	2	chr6q12
ToppCell	Adult-Mesenchymal-myofibroblast_cell-D122\|Adult / Lineage, Cell type, age group and donor	GABRG3 COL5A2 ITGBL1 OTOGL	2.74e-05	158	49	4	410fa08c9d880d27e80ec939fa5ba5a41dcb31ab
ToppCell	Children_(3_yrs)-Mesenchymal-myofibroblast_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	GABRG3 COL5A2 ITGBL1 PAMR1	3.91e-05	173	49	4	1f16d47f5548e257e4b17f8070c5619780a9c5fd
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL5A2 TUBB3 ITGBL1 PAMR1	5.51e-05	189	49	4	562f8bf5a7d38afb4a8f2415d617d5f79cfb7e3f
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL5A2 TUBB3 ITGBL1 PAMR1	5.51e-05	189	49	4	270dd4a0fc5260288fe6829837942c78b40ecec4
ToppCell	facs-Lung-nan-3m-Mesenchymal-Adventitial_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL5A2 ITGBL1 PAMR1 ENPP3	5.86e-05	192	49	4	a2c31390da4962bda9a936470b0b68fa1f5d47d1
ToppCell	facs-Lung-nan-3m-Mesenchymal-adventitial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL5A2 ITGBL1 PAMR1 ENPP3	5.86e-05	192	49	4	eeab1cef7c36ae824381952c5b2c982368c379fd
ToppCell	facs-Lung-nan-3m-Mesenchymal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL5A2 ITGBL1 PAMR1 ENPP3	5.98e-05	193	49	4	d9c20a092b507c43fcf7ccb04073fecd27d1749c
ToppCell	droplet-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	COL5A2 ITGBL1 PAMR1 ENPP3	6.10e-05	194	49	4	5594f7437448cb4b37d2d100f44d30c4a367df26
ToppCell	18-Distal-Mesenchymal-Mesenchyme_SERPINF1-high\|Distal / Age, Tissue, Lineage and Cell class	COL5A2 ITGBL1 PAMR1 LY6H	6.22e-05	195	49	4	f86737bff21d81673238813df61a15cfe88d0b15
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic-Fibro_myofibroblast\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	COL5A2 ITGBL1 PAMR1 LRRC18	6.22e-05	195	49	4	f5e91ce20a7ce528dc4c1a968c7bf096bf45c528
ToppCell	facs-Lung-nan\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL5A2 ITGBL1 PAMR1 ENPP3	6.35e-05	196	49	4	b05f77f3990b662682ffeaf0e4c2fb190e0a6e65
ToppCell	facs-Lung-nan-3m\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL5A2 ITGBL1 PAMR1 ENPP3	6.35e-05	196	49	4	787c6cd92035e0b1108c2c086c42a229016e476b
ToppCell	metastatic_Lymph_Node-Fibroblasts\|metastatic_Lymph_Node / Location, Cell class and cell subclass	GABRG3 COL5A2 ITGBL1 PAMR1	6.35e-05	196	49	4	275e153347caf94edc0c50021bbab49c8696fecb
ToppCell	distal-mesenchymal-Lipofibroblast-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	COL5A2 TUBB3 PAMR1 VWCE	6.47e-05	197	49	4	865010edcd7e3f79f505fcef7b33882095994aa8
ToppCell	distal-mesenchymal-Lipofibroblast\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	COL5A2 TUBB3 PAMR1 VWCE	6.47e-05	197	49	4	ceb83bdef16b58ee16193413bfb006f7715728b2
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_myofibroblast\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	GABRG3 COL5A2 ITGBL1 PAMR1	6.47e-05	197	49	4	6d0d68d460243a0259ada93ebda40fa7b3088eeb
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TPR PHF3 NUB1 TRIM22	6.86e-05	200	49	4	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	VE\|World / Condition, Cell_class and T cell subcluster	PHF3 CSNK1G2 NUB1 TRIM22	6.86e-05	200	49	4	8ae7cb81de3ffac5acdf3466d4b516d80cac95d3
Disease	fat body mass	ZNF280D LMX1B HHIPL2 NUB1	3.35e-04	217	45	4	EFO_0005409
Disease	unipolar depression, neuroticism measurement	EYS PHF3	6.14e-04	24	45	2	EFO_0003761, EFO_0007660
Disease	gestational age	EYS MALRD1 ZNF561	1.23e-03	138	45	3	EFO_0005112
Disease	neutrophil count, eosinophil count	TGFBRAP1 CSNK1G1 TGS1	4.21e-03	213	45	3	EFO_0004833, EFO_0004842
Disease	visual perception measurement	GABRG3 TRIM22 CFAP46	4.78e-03	223	45	3	EFO_0009700
Disease	neutrophil count, basophil count	TGFBRAP1 CSNK1G1 TGS1	4.84e-03	224	45	3	EFO_0004833, EFO_0005090
Disease	granulocyte count	TGFBRAP1 CSNK1G1 TGS1	6.85e-03	254	45	3	EFO_0007987

Protein segments in the cluster

Peptide	Gene	Start	Entry
RGIHKCIECCSEIKD	ZNF280D	621	Q6N043
CGVFPFCLCDKEEEV	ARSF	566	P54793
EIERKFIDCGCKENC	CFAP46	1766	Q8IYW2
FIDCGCKENCVDVKL	CFAP46	1771	Q8IYW2
EACKCQKEDLARAFC	ATP2C2	56	O75185
CCENEVEKVIEEIRC	NUB1	51	Q9Y5A7
CICREEFEGKNCEID	EYS	876	Q5T1H1
AEVEVVEEAKCCCFF	CSNK1G1	396	Q9HCP0
VEVADETKCCCFFKR	CSNK1G2	391	P78368
CKRDCLESEKQIDIC	DEFB114	36	Q30KQ6
IDDNKCVCRDGILLC	MUC19	1151	Q7Z5P9
ESEVKCCKEAVCVID	PDPR	511	Q8NCN5
VEEKDLCAACLRKCQ	LRRC18	201	Q8N456
GILKVDVDCCEKDLC	LY6H	96	O94772
KERRAKLYVCEECGC	OVOL1	206	O14753
SGEERCIACKLCEAI	NDUFS8	106	O00217
ACIEKLRLCDLVDDC	MALRD1	836	Q5VYJ5
LVDLGEGKICFCCEE	FAM189A2	41	Q15884
RCGNKIVEDNEECDC	ADAM30	401	Q9UKF2
EDTCVYECLDGKDCQ	GABRG3	401	Q99928
KEDRCIGCCEANKLV	CCDC18	426	Q5T9S5
LENCRCDVACKDRGD	ENPP3	66	O14638
RKKGYCECCQEAFEE	DBF4B	296	Q8NFT6
EEEVKRCLSCCEKGD	GIMAP8	511	Q8ND71
ICVCDNGAILCDKIE	COL5A2	61	P05997
LCGDYIKDILCQECS	HHIPL2	96	Q6UWX4
VYGKTCECDDRRCED	ITGBL1	356	O95965
SDCGCIQYLCEKDDV	OTOGL	2101	Q3ZCN5
KLYNEGCCKICKREE	OTOGL	2251	Q3ZCN5
CEYDQIECVCPGKRE	PAMR1	46	Q6UXH9
CLICKYKVDCEAVRG	SIRT1	371	Q96EB6
LFCEVDKEAICVVCR	TRIM52	236	Q96A61
EKFYDCEEEVERLCC	TIGD3	456	Q6B0B8
KLCDCKNCGEVFREQ	ZNF561	116	Q8N587
DKERVNIECVECCGR	TGFBRAP1	21	Q8WUH2
ECCECGKVFSRKDQL	ZNF268	361	Q14587
EVSKCVCRCEDLEKQ	TPR	1141	P12270
EDQAACGKLCIRRCE	PPM1M	86	Q96MI6
DGKVTCEKVRCEAAC	VWCE	411	Q96DN2
TEEKLCICEECGKTF	ZNF682	196	O95780
DKEYVCVKCCAEEDK	PHF3	761	Q92576
VLDVVRKECENCDCL	TUBB3	116	Q13509
EPLCCCEYIDRNGEK	ZDHHC23	21	Q8IYP9
NRLEGKLEEFCCEDC	ZMYM6	531	O95789
ELYCVEICCGDLQLD	VPS13B	3441	Q7Z7G8
TCFRCLECKEQCRDK	ZNF687	671	Q8N1G0
DCKILCLCSRAFVED	TGS1	21	Q96RS0
CRCKEENCAILKELV	THOP1	246	P52888
YCKECTIQEKDRDGC	PHF5A	71	Q7RTV0
IFCKEDGKVICWVCE	TRIM22	106	Q8IYM9
IICAEEKLYRCEECG	ZNF726P1	66	Q15940
EKLYRCEECGKAFCQ	ZNF726P1	71	Q15940
EELYDCKQCEDVFCK	ZNF560	211	Q96MR9
FCCCVCERQLRKGDE	LMX1B	141	O60663