Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	GTPase activator activity	RAB3GAP1 DLC1 STXBP5L RASGRP3 PLCB1 AGAP9 USP6NL ARAP2	2.95e-06	279	64	8	GO:0005096
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	RAB3GAP1 DLC1 STXBP5L RASGRP3 PLCB1 AGAP9 DENND1A USP6NL MADD ARAP2	4.51e-06	507	64	10	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	RAB3GAP1 DLC1 STXBP5L RASGRP3 PLCB1 AGAP9 DENND1A USP6NL MADD ARAP2	4.51e-06	507	64	10	GO:0030695
GeneOntologyMolecularFunction	enzyme activator activity	RAB3GAP1 DLC1 STXBP5L RASGRP3 PLCB1 AGAP9 APP USP6NL MADD ARAP2 CCNB1	6.75e-06	656	64	11	GO:0008047
GeneOntologyMolecularFunction	enzyme regulator activity	RAB3GAP1 TAOK3 DLC1 STXBP5L RASGRP3 PLCB1 AGAP9 APP DENND1A USP6NL MADD ARAP2 CCNB1	4.79e-04	1418	64	13	GO:0030234
GeneOntologyMolecularFunction	molecular function activator activity	RAB3GAP1 DLC1 STXBP5L RASGRP3 PRKACA PLCB1 AGAP9 APP USP6NL MADD ARAP2 CCNB1	4.80e-04	1233	64	12	GO:0140677
GeneOntologyBiologicalProcess	G2/M transition of mitotic cell cycle	TAOK3 PLCB1 SIN3A APP CLSPN CCNB1	7.65e-06	152	64	6	GO:0000086
GeneOntologyBiologicalProcess	cell cycle G2/M phase transition	TAOK3 PLCB1 SIN3A APP CLSPN CCNB1	1.50e-05	171	64	6	GO:0044839
GeneOntologyBiologicalProcess	regulation of cell cycle	CDK8 TAOK3 PBRM1 TTC28 BRD7 NUMA1 PRKACA ASPM PLCB1 SIN3A APP CLSPN MADD CCNB1	2.43e-05	1256	64	14	GO:0051726
GeneOntologyBiologicalProcess	regulation of G2/M transition of mitotic cell cycle	TAOK3 SIN3A APP CLSPN CCNB1	3.02e-05	116	64	5	GO:0010389
GeneOntologyBiologicalProcess	regulation of mitotic cell cycle phase transition	TAOK3 PBRM1 BRD7 PLCB1 SIN3A APP CLSPN CCNB1	3.31e-05	402	64	8	GO:1901990
GeneOntologyBiologicalProcess	regulation of cell cycle G2/M phase transition	TAOK3 SIN3A APP CLSPN CCNB1	5.40e-05	131	64	5	GO:1902749
GeneOntologyBiologicalProcess	regulation of GTPase activity	RGMA RAB3GAP1 RASGRP3 AGAP9 DENND1A USP6NL ARAP2	7.86e-05	335	64	7	GO:0043087
GeneOntologyBiologicalProcess	regulation of mitotic cell cycle	TAOK3 PBRM1 TTC28 BRD7 PLCB1 SIN3A APP CLSPN CCNB1	8.61e-05	594	64	9	GO:0007346
GeneOntologyBiologicalProcess	positive regulation of molecular function	RGMA RFK FLT1 RAB3GAP1 TAOK3 SLC9A1 DLC1 RPS6KA5 PLCB1 AGAP9 CLSPN DENND1A USP6NL ARAP2	9.98e-05	1430	64	14	GO:0044093
GeneOntologyBiologicalProcess	positive regulation of GTPase activity	RGMA RAB3GAP1 AGAP9 DENND1A USP6NL ARAP2	1.09e-04	244	64	6	GO:0043547
GeneOntologyBiologicalProcess	positive regulation of G2/M transition of mitotic cell cycle	SIN3A APP CCNB1	1.09e-04	30	64	3	GO:0010971
GeneOntologyBiologicalProcess	regulation of Rab protein signal transduction	DENND1A MADD	1.41e-04	6	64	2	GO:0032483
GeneOntologyBiologicalProcess	positive regulation of cell cycle G2/M phase transition	SIN3A APP CCNB1	1.45e-04	33	64	3	GO:1902751
GeneOntologyBiologicalProcess	mitotic cell cycle phase transition	TAOK3 PBRM1 BRD7 PLCB1 SIN3A APP CLSPN CCNB1	1.71e-04	509	64	8	GO:0044772
GeneOntologyBiologicalProcess	regulation of cell cycle phase transition	TAOK3 PBRM1 BRD7 PLCB1 SIN3A APP CLSPN CCNB1	1.88e-04	516	64	8	GO:1901987
GeneOntologyBiologicalProcess	mitotic cell cycle	TAOK3 PBRM1 TTC28 BRD7 NUMA1 PLCB1 SIN3A APP CLSPN GOLGA8A CCNB1	2.60e-04	1014	64	11	GO:0000278
GeneOntologyBiologicalProcess	cellular response to vasopressin	PLCB1 ADCY6	2.62e-04	8	64	2	GO:1904117
GeneOntologyBiologicalProcess	response to vasopressin	PLCB1 ADCY6	2.62e-04	8	64	2	GO:1904116
GeneOntologyBiologicalProcess	mitotic cell cycle process	TAOK3 PBRM1 BRD7 NUMA1 PLCB1 SIN3A APP CLSPN GOLGA8A CCNB1	2.80e-04	854	64	10	GO:1903047
GeneOntologyBiologicalProcess	positive regulation of catalytic activity	RGMA RFK FLT1 RAB3GAP1 TAOK3 DLC1 AGAP9 CLSPN DENND1A USP6NL ARAP2	2.93e-04	1028	64	11	GO:0043085
GeneOntologyBiologicalProcess	protein complex oligomerization	SLC9A1 PRF1 APP C9 GOLGA8A OPA1	3.10e-04	296	64	6	GO:0051259
GeneOntologyBiologicalProcess	regulation of sister chromatid segregation	PBRM1 BRD7 NUMA1 CCNB1	3.94e-04	111	64	4	GO:0033045
GeneOntologyBiologicalProcess	neural tube closure	RGMA DLC1 PRKACA OPA1	4.21e-04	113	64	4	GO:0001843
GeneOntologyBiologicalProcess	tube closure	RGMA DLC1 PRKACA OPA1	4.36e-04	114	64	4	GO:0060606
GeneOntologyBiologicalProcess	positive regulation of mitotic cell cycle phase transition	PLCB1 SIN3A APP CCNB1	4.81e-04	117	64	4	GO:1901992
GeneOntologyBiologicalProcess	primary neural tube formation	RGMA DLC1 PRKACA OPA1	5.29e-04	120	64	4	GO:0014020
GeneOntologyCellularComponent	microtubule minus-end	NUMA1 ASPM	1.92e-04	7	64	2	GO:0036449
GeneOntologyCellularComponent	kinetochore	ZNF276 PBRM1 BRD7 SIN3A CCNB1	2.32e-04	181	64	5	GO:0000776
GeneOntologyCellularComponent	spindle midzone	TTC28 NUMA1 APP	2.49e-04	40	64	3	GO:0051233
GeneOntologyCellularComponent	mitotic spindle pole	TTC28 NUMA1 ASPM	3.09e-04	43	64	3	GO:0097431
GeneOntologyCellularComponent	condensed chromosome, centromeric region	ZNF276 PBRM1 BRD7 SIN3A CCNB1	3.12e-04	193	64	5	GO:0000779
GeneOntologyCellularComponent	mitotic spindle	TTC28 NUMA1 ASPM GOLGA8A TAF1D	3.76e-04	201	64	5	GO:0072686
GeneOntologyCellularComponent	spindle pole	TTC28 NUMA1 ASPM GOLGA8A CCNB1	4.12e-04	205	64	5	GO:0000922
GeneOntologyCellularComponent	spindle	TTC28 NUMA1 ASPM APP GOLGA8A CCNB1 TAF1D	5.78e-04	471	64	7	GO:0005819
GeneOntologyCellularComponent	RSC-type complex	PBRM1 BRD7	9.44e-04	15	64	2	GO:0016586
GeneOntologyCellularComponent	mitotic spindle midzone	TTC28 NUMA1	1.08e-03	16	64	2	GO:1990023
GeneOntologyCellularComponent	chromosome, centromeric region	ZNF276 PBRM1 BRD7 SIN3A CCNB1	1.56e-03	276	64	5	GO:0000775
Domain	PLC-beta_CS	PLCB1 PLCB4	3.25e-05	3	62	2	IPR009535
Domain	DUF1154	PLCB1 PLCB4	3.25e-05	3	62	2	PF06631
Domain	ZINC_FINGER_C2H2_2	ZNF711 RLF ZBTB46 ZNF276 GTF3A ZNF577 ZNF569 ZNF41 ZNF652 TSHZ1 ZNF471	4.29e-05	775	62	11	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF711 RLF ZBTB46 ZNF276 GTF3A ZNF577 ZNF569 ZNF41 ZNF652 TSHZ1 ZNF471	4.39e-05	777	62	11	PS00028
Domain	Znf_C2H2-like	ZNF711 RLF ZBTB46 ZNF276 GTF3A ZNF577 ZNF569 ZNF41 ZNF652 TSHZ1 ZNF471	5.47e-05	796	62	11	IPR015880
Domain	Znf_C2H2	ZNF711 RLF ZBTB46 ZNF276 GTF3A ZNF577 ZNF569 ZNF41 ZNF652 TSHZ1 ZNF471	6.05e-05	805	62	11	IPR007087
Domain	ZnF_C2H2	ZNF711 RLF ZBTB46 ZNF276 GTF3A ZNF577 ZNF569 ZNF41 ZNF652 TSHZ1 ZNF471	6.26e-05	808	62	11	SM00355
Domain	PLC-beta	PLCB1 PLCB4	6.48e-05	4	62	2	IPR016280
Domain	-	ZNF711 RLF ZBTB46 ZNF276 GTF3A ZNF577 ZNF569 ZNF41 ZNF652 ZNF471	7.35e-05	679	62	10	3.30.160.60
Domain	-	PLCB1 PLCB4 GDE1	7.61e-05	25	62	3	3.20.20.190
Domain	PLC-like_Pdiesterase_TIM-brl	PLCB1 PLCB4 GDE1	7.61e-05	25	62	3	IPR017946
Domain	zf-C2H2	ZNF711 RLF ZBTB46 ZNF276 GTF3A ZNF577 ZNF569 ZNF41 ZNF652 ZNF471	8.70e-05	693	62	10	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF711 RLF ZBTB46 ZNF276 GTF3A ZNF577 ZNF569 ZNF41 ZNF652 ZNF471	8.81e-05	694	62	10	IPR013087
Domain	MACPF_CS	PRF1 C9	1.61e-04	6	62	2	IPR020863
Domain	MACPF_2	PRF1 C9	2.25e-04	7	62	2	PS51412
Domain	MACPF_1	PRF1 C9	2.25e-04	7	62	2	PS00279
Domain	MAC_perforin	PRF1 C9	4.80e-04	10	62	2	IPR001862
Domain	MACPF	PRF1 C9	5.85e-04	11	62	2	PF01823
Domain	MACPF	PRF1 C9	7.00e-04	12	62	2	SM00457
Domain	MACPF	PRF1 C9	7.00e-04	12	62	2	IPR020864
Domain	uDENN	DENND1A MADD	9.62e-04	14	62	2	SM00800
Domain	PLipase_C_Pinositol-sp_Y	PLCB1 PLCB4	1.11e-03	15	62	2	IPR001711
Domain	EF-hand_like	PLCB1 PLCB4	1.11e-03	15	62	2	PF09279
Domain	PIPLC_Y_DOMAIN	PLCB1 PLCB4	1.11e-03	15	62	2	PS50008
Domain	uDENN	DENND1A MADD	1.11e-03	15	62	2	PF03456
Domain	PI-PLC_fam	PLCB1 PLCB4	1.11e-03	15	62	2	IPR001192
Domain	PLC_EF-hand-like	PLCB1 PLCB4	1.11e-03	15	62	2	IPR015359
Domain	PI-PLC-Y	PLCB1 PLCB4	1.11e-03	15	62	2	PF00387
Domain	PLCYc	PLCB1 PLCB4	1.11e-03	15	62	2	SM00149
Domain	UDENN	DENND1A MADD	1.26e-03	16	62	2	PS50946
Domain	DDENN	DENND1A MADD	1.26e-03	16	62	2	PS50947
Domain	DENN	DENND1A MADD	1.26e-03	16	62	2	SM00799
Domain	dDENN	DENND1A MADD	1.26e-03	16	62	2	SM00801
Domain	DENN	DENND1A MADD	1.26e-03	16	62	2	PF02141
Domain	dDENN_dom	DENND1A MADD	1.26e-03	16	62	2	IPR005112
Domain	uDENN_dom	DENND1A MADD	1.26e-03	16	62	2	IPR005113
Domain	dDENN	DENND1A MADD	1.26e-03	16	62	2	PF03455
Domain	DENN	DENND1A MADD	1.26e-03	16	62	2	PS50211
Domain	DENN_dom	DENND1A MADD	1.26e-03	16	62	2	IPR001194
Domain	PI-PLC-X	PLCB1 PLCB4	1.60e-03	18	62	2	PF00388
Domain	PLCXc	PLCB1 PLCB4	1.60e-03	18	62	2	SM00148
Domain	PIPLC_X_DOMAIN	PLCB1 PLCB4	1.79e-03	19	62	2	PS50007
Domain	PLipase_C_PInositol-sp_X_dom	PLCB1 PLCB4	1.79e-03	19	62	2	IPR000909
Domain	ArfGap	AGAP9 ARAP2	4.16e-03	29	62	2	SM00105
Domain	ArfGap	AGAP9 ARAP2	4.16e-03	29	62	2	PF01412
Domain	ARFGAP	AGAP9 ARAP2	4.16e-03	29	62	2	PS50115
Domain	ArfGAP	AGAP9 ARAP2	4.16e-03	29	62	2	IPR001164
Pathway	REACTOME_G_PROTEIN_MEDIATED_EVENTS	PRKACA PLCB1 PLCB4 ADCY6	1.23e-05	39	52	4	MM14496
Pathway	PID_LPA4_PATHWAY	RPS6KA5 PRKACA ADCY6	2.09e-05	15	52	3	M56
Pathway	PID_CASPASE_PATHWAY	PRF1 NUMA1 APP MADD	3.62e-05	51	52	4	M220
Pathway	REACTOME_G_PROTEIN_MEDIATED_EVENTS	PRKACA PLCB1 PLCB4 ADCY6	4.54e-05	54	52	4	M26911
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MACHR_CA2_APOPTOTIC_PATHWAY	PLCB1 PLCB4 APP	6.01e-05	21	52	3	M47689
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	PLCB1 PLCB4 APP	6.94e-05	22	52	3	M47690
Pathway	REACTOME_OPIOID_SIGNALLING	PRKACA PLCB1 PLCB4 ADCY6	1.33e-04	71	52	4	MM14491
Pathway	WP_GPR143_IN_MELANOCYTES_AND_RETINAL_PIGMENT_EPITHELIUM_CELLS	PRKACA PLCB1 PLCB4	1.79e-04	30	52	3	M42578
Pathway	KEGG_MEDICUS_PATHOGEN_HCMV_UL33_TO_GNAQ_PLCB_G_CALCINEURIN_SIGNALING_PATHWAY	PLCB1 PLCB4	1.98e-04	6	52	2	M47548
Pathway	KEGG_MEDICUS_REFERENCE_CASR_PTH_SIGNALING_PATHWAY	PLCB1 PLCB4	2.77e-04	7	52	2	M47505
Pathway	REACTOME_OPIOID_SIGNALLING	PRKACA PLCB1 PLCB4 ADCY6	3.33e-04	90	52	4	M6467
Pathway	KEGG_GAP_JUNCTION	PRKACA PLCB1 PLCB4 ADCY6	3.33e-04	90	52	4	M4013
Pathway	WP_HIPPO_SIGNALING_REGULATION	FLT1 PRKACA PLCB1 PLCB4	4.60e-04	98	52	4	M39830
Pathway	KEGG_MELANOGENESIS	PRKACA PLCB1 PLCB4 ADCY6	5.16e-04	101	52	4	M7761
Pathway	KEGG_GNRH_SIGNALING_PATHWAY	PRKACA PLCB1 PLCB4 ADCY6	5.16e-04	101	52	4	M1979
Pathway	KEGG_MEDICUS_REFERENCE_TAC3_TACR3_PLC_PKC_SIGNALING_PATHWAY	PLCB1 PLCB4	5.89e-04	10	52	2	M47644
Pathway	KEGG_MEDICUS_REFERENCE_AVP_V2R_PKA_SIGNALING_PATHWAY	PRKACA ADCY6	5.89e-04	10	52	2	M47648
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SPTBN2_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY	PLCB1 PLCB4	5.89e-04	10	52	2	M47661
Pathway	WP_PHOSPHATIDYL_INOSITOL_PHOSPHATE_PATHWAY	PLCB1 PLCB4 PIP5K1C	6.43e-04	46	52	3	M48317
Pathway	KEGG_MEDICUS_REFERENCE_KISS1_KISS1R_PLCB_PKC_SIGNALING_PATHWAY	PLCB1 PLCB4	7.19e-04	11	52	2	M47637
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_PRKCG_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY	PLCB1 PLCB4	7.19e-04	11	52	2	M49033
Pathway	WP_PHOSPHOINOSITIDES_METABOLISM	PLCB1 PLCB4 PIP5K1C	7.74e-04	49	52	3	M40046
Pathway	KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION	PRKACA PLCB1 PLCB4 ADCY6	8.41e-04	115	52	4	M9387
Pathway	KEGG_MEDICUS_REFERENCE_TRH_TRHR_PLCB_PKC_SIGNALING_PATHWAY	PLCB1 PLCB4	8.60e-04	12	52	2	M47649
Pathway	KEGG_MEDICUS_REFERENCE_TSH_DUOX2_TG_SIGNALING_PATHWAY	PLCB1 PLCB4	8.60e-04	12	52	2	M47628
Pathway	KEGG_TASTE_TRANSDUCTION	TAS2R5 PRKACA ADCY6	9.21e-04	52	52	3	M5785
Pathway	WP_EFFECT_OF_OMEGA3_PUFA_ON_HUNTINGTONS_DISEASE_PATHWAYS	RAB3GAP1 RPS6KA5 SIN3A OPA1	9.56e-04	119	52	4	M48309
Pathway	REACTOME_G_ALPHA_I_SIGNALLING_EVENTS	TAS2R5 PRKACA PLCB1 PLCB4 APP ADCY6	1.00e-03	314	52	6	M600
Pathway	REACTOME_LOSS_OF_FUNCTION_OF_MECP2_IN_RETT_SYNDROME	PRKACA SIN3A	1.01e-03	13	52	2	M29766
Pathway	KEGG_MEDICUS_REFERENCE_MGLUR1_TRPC3_SIGNALING_PATHWAY	PLCB1 PLCB4	1.01e-03	13	52	2	M47656
Pathway	KEGG_INOSITOL_PHOSPHATE_METABOLISM	PLCB1 PLCB4 PIP5K1C	1.03e-03	54	52	3	M3896
Pathway	KEGG_MEDICUS_REFERENCE_EP_NE_ADRB_CAMP_SIGNALING_PATHWAY	PRKACA ADCY6	1.36e-03	15	52	2	M47794
Pathway	KEGG_MEDICUS_REFERENCE_PTH_PTH1R_PKA_SIGNALING_PATHWAY	PRKACA ADCY6	1.36e-03	15	52	2	M47504
Pathway	REACTOME_REGULATION_OF_INSULIN_SECRETION	PRKACA PLCB1 ADCY6	1.47e-03	61	52	3	MM15071
Pathway	KEGG_MEDICUS_REFERENCE_LHCGR_GNAS_PKA_SIGNALING_PATHWAY	PRKACA ADCY6	1.55e-03	16	52	2	M47645
Pathway	KEGG_MEDICUS_REFERENCE_FSHR_GNAS_PKA_SIGNALING_PATHWAY	PRKACA ADCY6	1.55e-03	16	52	2	M47650
Pathway	REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB	PRKACA ADCY6	1.55e-03	16	52	2	MM14492
Pathway	BIOCARTA_EFP_PATHWAY	CDK8 CCNB1	1.55e-03	16	52	2	M22011
Pathway	PID_ENDOTHELIN_PATHWAY	SLC9A1 PLCB1 ADCY6	1.61e-03	63	52	3	M8
Pathway	REACTOME_REGULATION_OF_MITF_M_DEPENDENT_GENES_INVOLVED_IN_CELL_CYCLE_AND_PROLIFERATION	SIN3A CCNB1	1.75e-03	17	52	2	M48240
Pathway	REACTOME_PKA_ACTIVATION_IN_GLUCAGON_SIGNALLING	PRKACA ADCY6	1.75e-03	17	52	2	M26995
Pathway	KEGG_MEDICUS_REFERENCE_CX3CR1_GNAI_AC_PKA_SIGNALING_PATHWAY	PRKACA ADCY6	1.75e-03	17	52	2	M47544
Pathway	REACTOME_CD209_DC_SIGN_SIGNALING	RPS6KA5 PRKACA	1.75e-03	17	52	2	MM15215
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABBERANT_ATXN2_3_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	PLCB1 PLCB4	1.97e-03	18	52	2	M47659
Pathway	KEGG_LONG_TERM_POTENTIATION	PRKACA PLCB1 PLCB4	2.18e-03	70	52	3	M3115
Pathway	KEGG_MEDICUS_REFERENCE_CXCL12_CXCR4_PKC_ERK_SIGNALING_PATHAWAY	PLCB1 PLCB4	2.19e-03	19	52	2	M47596
Pathway	KEGG_MEDICUS_PATHOGEN_HCMV_US28_TO_GNAQ_PLCB_G_CALCINEURIN_SIGNALING_PATHWAY	PLCB1 PLCB4	2.19e-03	19	52	2	M47543
Pathway	REACTOME_INTEGRATION_OF_ENERGY_METABOLISM	PRKACA PLCB1 ADCY6	2.36e-03	72	52	3	MM14631
Pathway	KEGG_MEDICUS_REFERENCE_MACHR_CA2_APOPTOTIC_PATHWAY	PLCB1 PLCB4	2.43e-03	20	52	2	M47688
Pathway	REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB	PRKACA ADCY6	2.43e-03	20	52	2	M759
Pathway	WP_ALZHEIMERS_DISEASE	PLCB1 PLCB4 APP	2.55e-03	74	52	3	MM15962
Pathway	KEGG_MEDICUS_REFERENCE_GNRH_GNRHR_PLCB_PKC_SIGNALING_PATHWAY	PLCB1 PLCB4	2.68e-03	21	52	2	M47638
Pathway	REACTOME_CD209_DC_SIGN_SIGNALING	RPS6KA5 PRKACA	2.68e-03	21	52	2	M27485
Pathway	KEGG_MEDICUS_REFERENCE_CXCR4_GNAQ_PLCB_G_CALCINEURIN_SIGNALING_PATHWAY	PLCB1 PLCB4	2.68e-03	21	52	2	M47542
Pathway	KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	PLCB1 PLCB4 PIP5K1C	2.75e-03	76	52	3	M9052
Pathway	WP_PKCGAMMA_CALCIUM_SIGNALING_IN_ATAXIA	PLCB1 PLCB4	2.94e-03	22	52	2	M39795
Pathway	WP_HEDGEHOG_SIGNALING_PATHWAY	SIN3A CCNB1	2.94e-03	22	52	2	MM15924
Pathway	KEGG_MEDICUS_REFERENCE_MGLUR5_CA2_APOPTOTIC_PATHWAY	PLCB1 PLCB4	2.94e-03	22	52	2	M47675
Pathway	REACTOME_REGULATION_OF_INSULIN_SECRETION	PRKACA PLCB1 ADCY6	2.96e-03	78	52	3	M1921
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	CDK8 ZNF711 PBRM1 TTC28 BRD7 ASPM SIN3A APP CLSPN EPB41L3 ADCY6 OPA1 ARAP2	1.03e-07	1116	64	13	31753913
Pubmed	The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells.	RPS6KA5 ASPM PLCB4 APP CLSPN ADCY6 CCNB1	2.08e-07	227	64	7	26410627
Pubmed	Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	ZNF862 PLCB1 PIP5K1C OPA1 ARAP2	1.51e-06	105	64	5	9628581
Pubmed	Genetic variants in PLCB4/PLCB1 as susceptibility loci for coronary artery aneurysm formation in Kawasaki disease in Han Chinese in Taiwan.	PLCB1 PLCB4	3.33e-06	2	64	2	26434682
Pubmed	Localization and molecular modelling of the membrane-inserted domain of the ninth component of human complement and perforin.	PRF1 C9	3.33e-06	2	64	2	2395434
Pubmed	Phospholipase C-β1 and β4 contribute to non-genetic cell-to-cell variability in histamine-induced calcium signals in HeLa cells.	PLCB1 PLCB4	3.33e-06	2	64	2	24475116
Pubmed	Phospholipase Cbeta serves as a coincidence detector through its Ca2+ dependency for triggering retrograde endocannabinoid signal.	PLCB1 PLCB4	3.33e-06	2	64	2	15664177
Pubmed	Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.	TAOK3 SLC9A1 FMN1 PLCB1 EPB41L3 PIP5K1C USP6NL	6.08e-06	377	64	7	38117590
Pubmed	Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence.	PBRM1 BRD7	9.99e-06	3	64	2	20660729
Pubmed	APP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle.	RAB3GAP1 APP	9.99e-06	3	64	2	19923287
Pubmed	Primary phospholipase C and brain disorders.	PLCB1 PLCB4	9.99e-06	3	64	2	26639088
Pubmed	Differential distribution of phospholipase C beta isoforms and diaglycerol kinase-beta in rodents cerebella corroborates the division of unipolar brush cells into two major subtypes.	PLCB1 PLCB4	9.99e-06	3	64	2	23503970
Pubmed	OPA1-anchored PKA phosphorylates perilipin 1 on S522 and S497 in adipocytes differentiated from human adipose stem cells.	PRKACA OPA1	9.99e-06	3	64	2	29688805
Pubmed	Mutation of the predicted p34cdc2 phosphorylation sites in NuMA impair the assembly of the mitotic spindle and block mitosis.	NUMA1 CCNB1	9.99e-06	3	64	2	7769006
Pubmed	Norepinephrine differentially modulates the innate inflammatory response provoked by amyloid-β peptide via action at β-adrenoceptors and activation of cAMP/PKA pathway in human THP-1 macrophages.	PRKACA APP	9.99e-06	3	64	2	22609331
Pubmed	Protein kinase A regulates cell cycle progression of mouse fertilized eggs by means of MPF.	PRKACA CCNB1	9.99e-06	3	64	2	15580572
Pubmed	HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease.	PRKACA PLCB1 PLCB4	1.03e-05	23	64	3	9730685
Pubmed	The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases.	PRKACA PLCB1 PLCB4	1.03e-05	23	64	3	9278385
Pubmed	Patterns of expression for the mRNA corresponding to the four isoforms of phospholipase Cbeta in mouse brain.	PLCB1 PLCB4	2.00e-05	4	64	2	9753089
Pubmed	Phospholipase C isozymes selectively couple to specific neurotransmitter receptors.	PLCB1 PLCB4	2.00e-05	4	64	2	9305844
Pubmed	Expression of phospholipase C beta family isoenzymes in C2C12 myoblasts during terminal differentiation.	PLCB1 PLCB4	2.00e-05	4	64	2	15174099
Pubmed	The RBPJ/DAPK3/UBE3A signaling axis induces PBRM1 degradation to modulate the sensitivity of renal cell carcinoma to CDK4/6 inhibitors.	PBRM1 PRKACA	2.00e-05	4	64	2	35368029
Pubmed	Phospholipase C-β1 potentiates glucose-stimulated insulin secretion.	PLCB1 PLCB4	2.00e-05	4	64	2	31268747
Pubmed	A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.	FLT1 RASGRP3	2.00e-05	4	64	2	15572660
Pubmed	Protein kinase A-induced phosphorylation of the p65 subunit of nuclear factor-kappaB promotes Schwann cell differentiation into a myelinating phenotype.	RPS6KA5 PRKACA	2.00e-05	4	64	2	18385332
Pubmed	PLCβ isoforms differ in their subcellular location and their CT-domain dependent interaction with Gαq.	PLCB1 PLCB4	2.00e-05	4	64	2	23006664
Pubmed	An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency.	PBRM1 BRD7 NUMA1	2.10e-05	29	64	3	19279220
Pubmed	A human MAP kinase interactome.	SLC9A1 RPS6KA5 PRKACA PLCB1 EPB41L3 MADD MSL2	3.11e-05	486	64	7	20936779
Pubmed	Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery.	PBRM1 CLSPN	3.32e-05	5	64	2	16934469
Pubmed	Protein kinase A gating of a pseudopodial-located RhoA/ROCK/p38/NHE1 signal module regulates invasion in breast cancer cell lines.	SLC9A1 PRKACA	3.32e-05	5	64	2	15843433
Pubmed	Expression and immunohistochemical localization of eight phospholipase C isoforms in adult male mouse cerebellar cortex.	PLCB1 PLCB4	4.98e-05	6	64	2	8739298
Pubmed	PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters.	RASGRP3 PRKACA	4.98e-05	6	64	2	15213298
Pubmed	Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1).	RPS6KA5 PRKACA	4.98e-05	6	64	2	12569367
Pubmed	Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth.	RPS6KA5 PRKACA	4.98e-05	6	64	2	11297520
Pubmed	Smurf1 regulates lung cancer cell growth and migration through interaction with and ubiquitination of PIPKIγ.	PRKACA PIP5K1C	4.98e-05	6	64	2	28581524
Pubmed	Purification and characterization of membrane-bound phospholipase C specific for phosphoinositides from human platelets.	PLCB1 PLCB4	4.98e-05	6	64	2	2841328
Pubmed	Ser276 phosphorylation of NF-kB p65 by MSK1 controls SCF expression in inflammation.	RPS6KA5 PRKACA	4.98e-05	6	64	2	19197368
Pubmed	Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155.	RPS6KA5 PRKACA	6.96e-05	7	64	2	10880354
Pubmed	Genetic dissection of gustatory sensitivity to bitterness (sucrose octaacetate) in mice.	PLCB1 PLCB4	6.96e-05	7	64	2	10609087
Pubmed	CHD7 cooperates with PBAF to control multipotent neural crest formation.	PBRM1 BRD7	9.27e-05	8	64	2	20130577
Pubmed	MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14.	RPS6KA5 PRKACA	9.27e-05	8	64	2	12773393
Pubmed	RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis.	GTF3A CCNB1	9.27e-05	8	64	2	12775724
Pubmed	Bicc1 links the regulation of cAMP signaling in polycystic kidneys to microRNA-induced gene silencing.	PRKACA ADCY6	9.27e-05	8	64	2	22641646
Pubmed	Regulation of histone deacetylase 2 by protein kinase CK2.	PRKACA SIN3A	9.27e-05	8	64	2	12082111
Pubmed	Screening for cell migration inhibitors via automated microscopy reveals a Rho-kinase inhibitor.	RPS6KA5 PRKACA	9.27e-05	8	64	2	15797222
Pubmed	Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1).	RPS6KA5 PRKACA	9.27e-05	8	64	2	12628924
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TTC28 PIP5K1C ADCY6 OPA1 MADD ARAP2	1.05e-04	407	64	6	12693553
Pubmed	Response gene to complement 32 is required for C5b-9 induced cell cycle activation in endothelial cells.	C9 CCNB1	1.19e-04	9	64	2	19162005
Pubmed	Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex.	CDK8 SIN3A	1.19e-04	9	64	2	9150135
Pubmed	Multiple tumor suppressors regulate a HIF-dependent negative feedback loop via ISGF3 in human clear cell renal cancer.	PBRM1 BRD7	1.19e-04	9	64	2	30355451
Pubmed	Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line.	PLCB1 PLCB4	1.19e-04	9	64	2	7589147
Pubmed	Uncovering the Translational Regulatory Activity of the Tumor Suppressor BRCA1.	TRIM45 GOLGA8A	1.19e-04	9	64	2	32290274
Pubmed	MAD1-dependent recruitment of CDK1-CCNB1 to kinetochores promotes spindle checkpoint signaling.	NUMA1 CCNB1	1.19e-04	9	64	2	30674583
Pubmed	Phospholipase C-beta 1 is a GTPase-activating protein for Gq/11, its physiologic regulator.	PLCB1 PLCB4	1.19e-04	9	64	2	1322796
Pubmed	Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat.	PLCB1 PLCB4	1.19e-04	9	64	2	10501179
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	ZNF711 RLF PBRM1 SBNO1 BRD7 NUMA1 SIN3A	1.26e-04	608	64	7	36089195
Pubmed	Polybromo protein BAF180 functions in mammalian cardiac chamber maturation.	FLT1 PBRM1	1.49e-04	10	64	2	15601824
Pubmed	HIV-1 Tat-peptide inhibits protein kinase C and protein kinase A through substrate competition.	RPS6KA5 PRKACA	1.49e-04	10	64	2	20433920
Pubmed	Expression of phospholipase C isozymes by murine B lymphocytes.	PLCB1 PLCB4	1.49e-04	10	64	2	2033248
Pubmed	Implantation failure in mice with a disruption in Phospholipase C beta 1 gene: lack of embryonic attachment, aberrant steroid hormone signalling and defective endocannabinoid metabolism.	PLCB1 PLCB4	1.49e-04	10	64	2	23295235
Pubmed	Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.	RPS6KA5 PRKACA	1.81e-04	11	64	2	11500364
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	CDK8 ZNF711 RLF PBRM1 TTC28 PARG EPB41L3	1.82e-04	645	64	7	25281560
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	TAOK3 TTC28 PARG SIN3A CLSPN ADCY6 MADD	1.90e-04	650	64	7	38777146
Pubmed	Cyclin-dependent kinase-mediated phosphorylation of RBP1 and pRb promotes their dissociation to mediate release of the SAP30·mSin3·HDAC transcriptional repressor complex.	SIN3A CCNB1	2.17e-04	12	64	2	21148318
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	PBRM1 TTC28 BRD7 NUMA1 SIN3A CCNB1	2.25e-04	469	64	6	27634302
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	PBRM1 RPS6KA5 FMN1 PLCB1 PIP5K1C MADD	2.41e-04	475	64	6	31040226
Pubmed	New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium.	APP EPB41L3	2.57e-04	13	64	2	16368544
Pubmed	Angiogenic factor imbalance precedes complement deposition in placentae of the BPH/5 model of preeclampsia.	FLT1 C9	2.57e-04	13	64	2	29279353
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	FLT1 TAOK3 NUMA1 PLCB4 EPB41L3 OPA1	3.07e-04	497	64	6	36774506
Pubmed	PBAF chromatin-remodeling complex requires a novel specificity subunit, BAF200, to regulate expression of selective interferon-responsive genes.	PBRM1 BRD7	3.45e-04	15	64	2	15985610
Pubmed	cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes.	PRKACA ADCY6	3.45e-04	15	64	2	2165385
Pubmed	Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1).	PLCB1 PLCB4	3.45e-04	15	64	2	11118617
Pubmed	Synergistic Signaling by Light and Acetylcholine in Mouse Iris Sphincter Muscle.	PLCB1 PLCB4	3.45e-04	15	64	2	28578927
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	PBRM1 BRD7 NUMA1 PRKACA PLCB1 EPB41L3 GOLGA8A OPA1	3.77e-04	963	64	8	28671696
Pubmed	Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.	RAB3GAP1 TAOK3 PRKACA ASPM APP EPB41L3	4.45e-04	533	64	6	25544563
Pubmed	The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes.	PBRM1 BRD7	4.45e-04	17	64	2	11078522
Pubmed	Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyclosome substrate.	PARG NUMA1	4.45e-04	17	64	2	21628590
Pubmed	Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns.	PBRM1 SIN3A	4.45e-04	17	64	2	14519686
Pubmed	The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription.	CDK8 CCNB1	4.45e-04	17	64	2	16109376
Pubmed	An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse.	RLF PBRM1	5.00e-04	18	64	2	24025402
Pubmed	Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway.	PLCB1 PLCB4	5.00e-04	18	64	2	1979339
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	CDK8 PHAF1 PBRM1 RASGRP3 ASPM	5.55e-04	363	64	5	14691545
Pubmed	Variability in the common genetic architecture of social-communication spectrum phenotypes during childhood and adolescence.	PLCB1 EPB41L3	5.59e-04	19	64	2	24564958
Pubmed	Requirement for PBAF in transcriptional repression and repair at DNA breaks in actively transcribed regions of chromatin.	PBRM1 BRD7	5.59e-04	19	64	2	25066234
Pubmed	Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes.	PBRM1 BRD7	5.59e-04	19	64	2	12110891
Pubmed	BRD7, a novel PBAF-specific SWI/SNF subunit, is required for target gene activation and repression in embryonic stem cells.	PBRM1 BRD7	5.59e-04	19	64	2	18809673
Pubmed	Synapsin and synaptic vesicle protein expression during embryonic and post-natal lens fiber cell differentiation.	PRKACA APP	5.59e-04	19	64	2	15529118
Pubmed	Role of the Pbrm1 subunit and the PBAF complex in Schwann cell development.	PBRM1 BRD7	5.59e-04	19	64	2	35173232
Pubmed	Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.	FLT1 RPS6KA5 PRKACA APP CCNB1	6.12e-04	371	64	5	25241761
Pubmed	Components of the human SWI/SNF complex are enriched in active chromatin and are associated with the nuclear matrix.	PBRM1 BRD7	6.20e-04	20	64	2	9128241
Pubmed	Coronary development is regulated by ATP-dependent SWI/SNF chromatin remodeling component BAF180.	FLT1 PBRM1	6.84e-04	21	64	2	18508041
Pubmed	Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in Intrinsically Photosensitive Retinal Ganglion Cells.	PLCB1 PLCB4	6.84e-04	21	64	2	30270038
Pubmed	Rapid cDNA sequencing (expressed sequence tags) from a directionally cloned human infant brain cDNA library.	RASGRP3 EPB41L3	6.84e-04	21	64	2	8401585
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	CDK8 RLF RAB3GAP1 PBRM1 SBNO1 BRD7 ASPM CLSPN MSL2	6.95e-04	1327	64	9	32694731
Pubmed	Sin3a is essential for the genome integrity and viability of pluripotent cells.	SIN3A CCNB1	8.23e-04	23	64	2	22206758
Pubmed	Diversity and specialization of mammalian SWI/SNF complexes.	PBRM1 BRD7	8.23e-04	23	64	2	8804307
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	PBRM1 BRD7 TSHZ1 APP CCNB1	8.39e-04	398	64	5	35016035
Pubmed	The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery.	TTC28 PARG GOLGA8A DENND1A	8.68e-04	230	64	4	35449600
Pubmed	Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	STXBP5L ZNF652 EPB41L3	8.96e-04	102	64	3	10231032
Pubmed	Centrosome-related genes, genetic variation, and risk of breast cancer.	NUMA1 ASPM CCNB1	8.96e-04	102	64	3	20508983
Cytoband	20p12	PLCB1 PLCB4	1.72e-04	14	64	2	20p12
Cytoband	13q12	CDK8 FLT1	5.18e-04	24	64	2	13q12
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF711 RLF ZBTB46 ZNF276 GTF3A ZNF577 ZNF569 ZNF41 ZNF862 ZNF652 TSHZ1 ZNF471	6.94e-08	718	43	12	28
GeneFamily	Phospholipases\|C2 domain containing phospholipases	PLCB1 PLCB4	9.21e-04	19	43	2	832
GeneFamily	Guanylate cyclase receptors\|DENN/MADD domain containing	DENND1A MADD	1.60e-03	25	43	2	504
GeneFamily	ArfGAPs	AGAP9 ARAP2	2.78e-03	33	43	2	395
GeneFamily	Phospholipases	PLCB1 PLCB4	4.48e-03	42	43	2	467
GeneFamily	X-linked mental retardation\|Angiotensin receptors	ZNF711 ZNF41	7.05e-03	53	43	2	103
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	CDK8 RLF RAB3GAP1 TAOK3 DLC1 TTC28 PARG PLCB4 APP OPA1 ARAP2	6.47e-06	856	64	11	M4500
Coexpression	GSE23695_CD57_POS_VS_NEG_NK_CELL_UP	PBRM1 ZNF862 ZNF652 BRD7 PIP5K1C MADD	9.23e-06	199	64	6	M7784
Coexpression	GSE21380_NON_TFH_VS_GERMINAL_CENTER_TFH_CD4_TCELL_DN	RPS6KA5 SBNO1 PARG PLCB1 CLSPN MADD	9.50e-06	200	64	6	M7505
Coexpression	LAKE_ADULT_KIDNEY_C24_ENDOTHELIAL_CELLS_AEA_AND_DVR	FLT1 TTC28 PLCB1 PLCB4 APP	3.55e-05	152	64	5	M39243
ToppCell	facs-Lung-nan-3m-Endothelial-Capillary_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 DLC1 RASGRP3 PLCB1 APP ARAP2	3.41e-07	192	64	6	4bab9754cfd8b9c2d7cc1490e8a29f58c3c26f6c
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLT1 DLC1 RASGRP3 PLCB1 APP ARAP2	3.62e-07	194	64	6	c6cee7d15af76f9a60d7f414ef0bcc1735c47b7a
ToppCell	Parenchymal-NucSeq-Endothelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ZBTB46 FLT1 RASGRP3 PLCB1 PLCB4 APP	4.20e-07	199	64	6	a4a9a1c2a34b5a8318a55d1211d6c8661ca9793e
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_bronchial_vessel\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ZBTB46 FLT1 PLCB1 PLCB4 APP	3.76e-06	163	64	5	977a970b1296234c22178420294cea73506ee02f
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_bronchial_vessel-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ZBTB46 FLT1 PLCB1 PLCB4 APP	3.76e-06	163	64	5	ba7d02db0f0e2f9916ec8db52c067c87b6917c23
ToppCell	343B-Lymphocytic-NK_cells-Proliferating_NK_cell\|343B / Donor, Lineage, Cell class and subclass (all cells)	RLF ZNF862 ASPM CLSPN CCNB1	4.49e-06	169	64	5	02fa66a91b8bd2bf971aec4f5ec58318b5bfdf14
ToppCell	367C-Lymphocytic-NK_cells-Proliferating_NK_cell\|367C / Donor, Lineage, Cell class and subclass (all cells)	TRIM45 PRF1 ASPM CLSPN CCNB1	4.76e-06	171	64	5	4ede6e916e593f208f2f8ccf82ef2335e061fc86
ToppCell	Control-Endothelial_cells-Systemic_venous_endothelial_cells\|Control / group, cell type (main and fine annotations)	FLT1 ADAM23 RASGRP3 PLCB1 PLCB4	4.89e-06	172	64	5	c55dce1ed3ed7312394b4e050e1de852a994e130
ToppCell	Adult-Endothelial-endothelial_cell_of_vein\|Adult / Lineage, Cell type, age group and donor	ZBTB46 FLT1 ADAM23 PLCB1 PLCB4	5.47e-06	176	64	5	043683c61c5d1a7f8a4666a612310246bd3d83a2
ToppCell	COVID-19-kidney-Mito-rich_EC\|kidney / Disease (COVID-19 only), tissue and cell type	ZBTB46 FLT1 DLC1 RASGRP3 PLCB1	6.62e-06	183	64	5	3c4153479fc4ab2d073d92cee120480015555914
ToppCell	pdx\|World / Sample and Cell Type and Tumor Cluster (all cells)	TAOK3 TTC28 PLCB1 PLCB4 ADCY6	7.16e-06	186	64	5	de8e538c8767d41b8a52f5e58ba1affd4e7244c4
ToppCell	Control-Endothelial_cells-Endothelial_cells_(other)\|Control / group, cell type (main and fine annotations)	ZBTB46 FLT1 TTC28 PLCB4 APP	7.16e-06	186	64	5	c6075fe84226b370c5139066793844ad33ae2db1
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLT1 RASGRP3 ASPM PLCB1 CCNB1	7.16e-06	186	64	5	e9d12f2fcd346fc8d00f7178324ea5997628df8a
ToppCell	pdx-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	TAOK3 TTC28 PLCB1 PLCB4 ADCY6	7.16e-06	186	64	5	0b88a87158a9ca8de3bf40a4ff1687150707a5f0
ToppCell	Control-Endothelial-VE_Peribronchial\|Endothelial / Disease state, Lineage and Cell class	FLT1 ADAM23 PLCB1 EPB41L3 ARAP2	7.35e-06	187	64	5	5429ae85942b8ec3895cceb63c663de3c24ca064
ToppCell	Children_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FLT1 TTC28 RASGRP3 PLCB1 PLCB4	7.54e-06	188	64	5	117dc80fa940e6aa1b0187a43fdde33f3fcb578f
ToppCell	E17.5-Epithelial-epithelial_progenitor_cell-epithelial_progenitor_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PHAF1 TAOK3 BRD7 APP GDE1	7.94e-06	190	64	5	8e9ba1f1af520564a1a7dfa9ef74ef5f0d0bf0d5
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 DLC1 ADAM23 RASGRP3 APP	8.14e-06	191	64	5	1924af7d8b0a0b892e480a9fd6d874941b0c0b5d
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 DLC1 ADAM23 RASGRP3 APP	8.14e-06	191	64	5	88f91e57a1409bdeb91e9bf47510a6fb998a1bf5
ToppCell	COVID-19-kidney-VWF+PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ZBTB46 FLT1 PLCB1 TSHZ1 APP	8.14e-06	191	64	5	2f00d0b7b2ffce8eb3eb5bbae49a0d425b23c982
ToppCell	COVID-19-kidney-AQP1+PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ZBTB46 FLT1 TTC28 PLCB1 APP	8.35e-06	192	64	5	27ff3621e177e7932dd44dd6baa81551ea75a874
ToppCell	nucseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-SVEC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	FLT1 ADAM23 PLCB1 PLCB4 APP	8.35e-06	192	64	5	c3dda7c48732b0b8bde36de282d64192f5e9b98f
ToppCell	facs-Liver-Non-hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 DLC1 ADAM23 RASGRP3 APP	8.35e-06	192	64	5	2bfac6b3956265205ca47d06888851ed68b65999
ToppCell	facs-Liver-Non-hepatocytes-24m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 DLC1 ADAM23 RASGRP3 APP	8.35e-06	192	64	5	d525f7f088a53110912600a7c9f6d33b9270d534
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 DLC1 TTC28 ADAM23 RASGRP3	8.56e-06	193	64	5	826b8dd801298b3e0cd76232feae5a14026b8806
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 DLC1 TTC28 ADAM23 RASGRP3	8.56e-06	193	64	5	87d3a577d37fb0cb4b6313c596310de452bc3872
ToppCell	facs-Liver-Liver_non-hepato/SCs-18m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RGMA FLT1 DLC1 ADAM23 APP	8.56e-06	193	64	5	2483bb7f398e4fa0ef09c8bd584ed25703853f03
ToppCell	facs-Liver-Non-hepatocytes-3m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 DLC1 ADAM23 RASGRP3 APP	8.56e-06	193	64	5	8084fa0ce61f1f4a728423b6b81df04eaa5af5b6
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLT1 DLC1 RASGRP3 PLCB1 ARAP2	8.56e-06	193	64	5	097a244cf37ce6c1ace9bae56beb7de59442cd6b
ToppCell	facs-Liver-Non-hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 DLC1 ADAM23 RASGRP3 APP	8.78e-06	194	64	5	c8b9551b93a5aed62154b487db90130604a6125c
ToppCell	facs-Lung-nan-3m-Endothelial-endothelial_cell_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 DLC1 RASGRP3 APP ARAP2	8.78e-06	194	64	5	f159ef8541d75a4e98468947f231bb463bec922c
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FLT1 DLC1 RASGRP3 PLCB1 PLCB4	8.78e-06	194	64	5	0b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLT1 DLC1 RASGRP3 PLCB1 ARAP2	8.78e-06	194	64	5	44c7d4b75f3b7c9301eba20610e548a01a84ae40
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLT1 DLC1 ADAM23 RASGRP3 PLCB1	8.78e-06	194	64	5	7f24023df47935286f185dd428d48797daf26f49
ToppCell	IPF-Endothelial-VE_Peribronchial\|IPF / Disease state, Lineage and Cell class	FLT1 DLC1 ADAM23 PLCB1 PLCB4	9.00e-06	195	64	5	2c3ad3cb79f11119ac69c413a938d21199145040
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLT1 DLC1 ADAM23 RASGRP3 PLCB1	9.00e-06	195	64	5	cd011433b3b9bfb1adb13eca2f3f2a5db024cd94
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c12-MKI67-TYROBP\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PRF1 ASPM CLSPN C9 CCNB1	9.23e-06	196	64	5	f70a2b227716a0df3c1aa6a414b822e63f209a43
ToppCell	facs-Liver-Liver_non-hepato/SCs-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 DLC1 ADAM23 RASGRP3 APP	9.23e-06	196	64	5	81900dcc9451ff6606ec940c16b559d73247590e
ToppCell	Endothelial\|World / Lineage, Cell type, age group and donor	ZBTB46 FLT1 RASGRP3 PLCB4 APP	9.23e-06	196	64	5	96c6d78482a130ce4e29f6629972a06d10d7530e
ToppCell	facs-Liver-Non-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 DLC1 ADAM23 RASGRP3 APP	9.46e-06	197	64	5	deefb492b5f0e6014144bd465c4a6ae4206e8739
ToppCell	facs-Liver-Liver_non-hepato/SCs-18m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 DLC1 ADAM23 RASGRP3 APP	9.46e-06	197	64	5	d584d0334ea97e3fa8c4cd869f5eeea2c7a1ed04
ToppCell	facs-Liver-Non-hepatocytes-3m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 DLC1 ADAM23 RASGRP3 APP	9.46e-06	197	64	5	a6aaa6faea348291023f0bc4b0f83fbc67d91da6
ToppCell	facs-Liver-Liver_non-hepato/SCs-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 DLC1 ADAM23 RASGRP3 APP	9.46e-06	197	64	5	412091994196a06c2779b4c2cfed84be889a5f8d
ToppCell	facs-Liver-Non-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 DLC1 ADAM23 RASGRP3 APP	9.69e-06	198	64	5	f0f1816a0ed3ae8207442602f5cbe4de0382e4b3
ToppCell	Sepsis-ICU-NoSEP-Myeloid-tDC\|ICU-NoSEP / Disease, condition lineage and cell class	ZNF711 FLT1 ZNF862 APP EPB41L3	9.93e-06	199	64	5	90ddd686b8f39c6f6134b9b048396cebcf8d0448
ToppCell	mild-MAIT\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	PRF1 ZNF652 PLCB1 GOLGA8A ARAP2	9.93e-06	199	64	5	cbe1fb6d2c5fca7a1baf1ad20afcdf8e8e11bd84
ToppCell	LPS-antiTNF-Unknown-Endothelial\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ASPM TSHZ1 CLSPN CCNB1	3.70e-05	130	64	4	615c233c7c2600c1c2bc5cf5b1c501fc474564ef
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Macrophage-macrophage,_alveolar-Macro_c2-CCL3L1\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	RGMA PARG DENND1A CCNB1	6.80e-05	152	64	4	18194f757d319958f26e5a91f56d89f25711236f
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Neuronal-cortical_neurons_1\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	PHAF1 PIP5K1C ZNF471 MADD	7.89e-05	158	64	4	1f94622186d8329357fa06785e03eeacf29ab1ce
ToppCell	Endothelial-endothelial_cell_of_bronchial_vessel\|World / Lineage, Cell type, age group and donor	ZBTB46 FLT1 PLCB1 PLCB4	9.34e-05	165	64	4	84e553d699ac56df89a77248f7308b9133e1b683
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_vein-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FLT1 RASGRP3 PLCB1 PLCB4	9.56e-05	166	64	4	f7926ee266dcbf10df375cd921f1db5a2fa604f8
ToppCell	Adult-Endothelial-endothelial_cell_of_vein-D175\|Adult / Lineage, Cell type, age group and donor	ZBTB46 FLT1 ADAM23 PLCB4	1.02e-04	169	64	4	e1f0298236e4a1c59077c14f0dd29a78fac12648
ToppCell	LV-16._Neuronal\|LV / Chamber and Cluster_Paper	DLC1 TAS2R5 PLCB1 ARAP2	1.02e-04	169	64	4	a8fc8ab0f0757e939e213efb61c03cfe390bf7d2
ToppCell	PND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_G2M\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RPS6KA5 ASPM CLSPN CCNB1	1.05e-04	170	64	4	b04e2f84024baaae9b4ff19bdac8c69afdb92a76
ToppCell	droplet-Liver-Npc-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 DLC1 ADAM23 RASGRP3	1.10e-04	172	64	4	a6fb1bde8d942c7b5caaf7bd14de0b7ce32fda55
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Ccr7+_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRIM45 ZBTB46 ADAM23 ADCY6	1.15e-04	174	64	4	7be0c6248e77f2d0260b852b01e17892f7828f1b
ToppCell	ASK428-Immune-B_cell\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	ZNF577 ZNF569 ZNF41 CCNB1	1.15e-04	174	64	4	b5a7a612a515736cf3489afd0f6ad2054d54526f
ToppCell	facs-Trachea-18m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l7\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ZBTB46 FLT1 RASGRP3 PLCB4	1.15e-04	174	64	4	b1bcd5f4505d2ccef4183fcfbf1de81964b3f9e0
ToppCell	facs-Trachea-18m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l10\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ZNF711 FLT1 RASGRP3 PLCB1	1.15e-04	174	64	4	40bb87d219aafab0357ab0d797efd38085fc0312
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_VWA2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RGMA DLC1 ASPM PLCB4	1.15e-04	174	64	4	43c0e758fa8683708475aec846929ac70d41d7f5
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L5-6_FEZF2_ANKRD20A1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RGMA DLC1 PLCB4 SLC5A8	1.15e-04	174	64	4	99eb5e1aee136c7039e23b68a43a0fa3d775859f
ToppCell	Adult-Endothelial-endothelial_cell_of_vein-D231\|Adult / Lineage, Cell type, age group and donor	FLT1 ADAM23 PLCB1 PLCB4	1.15e-04	174	64	4	2dd647c4fdf99fd1f7b838efef01baf2cbc3446d
ToppCell	droplet-Lung-1m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TRIM45 ZBTB46 ADAM23 ADCY6	1.17e-04	175	64	4	1b910c08d2bfbcc77431ee66103e63a11a9d39fe
ToppCell	Healthy_donor-Plasmablast\|World / disease group, cell group and cell class (v2)	RASGRP3 ASPM CLSPN CCNB1	1.17e-04	175	64	4	5293e00fda63a291aa393bdf82ebd4b80265049f
ToppCell	367C-Lymphocytic-NK_cells-Proliferating_NK_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	TRIM45 ASPM CLSPN CCNB1	1.17e-04	175	64	4	0b1aaa028ba844d4bcb4509fdab8bee648373935
ToppCell	10x5'-blood-Lymphocytic_B_plasma-Plasmablasts\|blood / Manually curated celltypes from each tissue	RASGRP3 ASPM CLSPN CCNB1	1.17e-04	175	64	4	2e048bf7961c3d86b6e12a1ebae3b3f2359af457
ToppCell	Control-Neuronal_cells-Neuronal_cells\|Control / group, cell type (main and fine annotations)	RASGRP3 PLCB1 PLCB4 APP	1.20e-04	176	64	4	98c07d26ba0dc0fe15ca0ea81f633d4591782bd1
ToppCell	Control-Neuronal_cells\|Control / group, cell type (main and fine annotations)	RASGRP3 PLCB1 PLCB4 APP	1.20e-04	176	64	4	c29d09ecf0eb17f767d78af4b7f2e7725c967ff8
ToppCell	Healthy_donor-Plasmablast\|Healthy_donor / disease group, cell group and cell class (v2)	RASGRP3 ASPM CLSPN CCNB1	1.25e-04	178	64	4	388b8b4fa20dcc6e9ae4b06118e20b2c20c52bde
ToppCell	COVID-19-kidney-Stressed_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FLT1 PLCB1 TSHZ1 APP	1.28e-04	179	64	4	754f69bac7a1d5137f5141f6193285ccbfe361cb
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_B-B_atypical-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	ZBTB46 RAB3GAP1 ZNF577 RASGRP3	1.28e-04	179	64	4	5be883d7d0be3180bb9844e4a757f0dd247294e4
ToppCell	COVID-19-kidney-AQP1+SLC14A1+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FLT1 TTC28 PLCB1 PLCB4	1.28e-04	179	64	4	1ce8d18f63e8dd2d3db41fbeca4601bd3b305fba
ToppCell	COVID-19-kidney-PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ZBTB46 FLT1 PLCB1 APP	1.31e-04	180	64	4	493cf8d1a8f2a1ed2672f394a0338b110fd81d88
ToppCell	droplet-Liver-LIVER_HEP-30m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 TTC28 ADAM23 RASGRP3	1.31e-04	180	64	4	dd1b10c7f5a0fbc63163844ca1882884a24a84d3
ToppCell	droplet-Liver-LIVER_HEP\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 TTC28 ADAM23 RASGRP3	1.31e-04	180	64	4	423454e3390080ae03bb3cbb267255ebfe4df080
ToppCell	ICU-NoSEP-Myeloid-tDC\|ICU-NoSEP / Disease, Lineage and Cell Type	ZNF711 FLT1 ZNF862 APP	1.31e-04	180	64	4	be665e801512f6aaf6b3ecb26153bbdeb24619ac
ToppCell	RA-16._Neuronal\|World / Chamber and Cluster_Paper	DLC1 ZNF652 PLCB1 ARAP2	1.33e-04	181	64	4	7d22a43f887e0747f0cb87ba364ff27905ee6eec
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 DLC1 ADAM23 RASGRP3	1.33e-04	181	64	4	4df7972f88117108698efd06b124b232f8588981
ToppCell	droplet-Lung-3m-Hematologic-lymphocytic-Proliferating_T_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ASPM SLC5A8 CLSPN CCNB1	1.33e-04	181	64	4	cf13bf7a531a2d40f8d778629cf2431b684f65f3
ToppCell	droplet-Lung-3m-Hematologic-lymphocytic-Proliferating_T_cell-proliferating_T\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ASPM SLC5A8 CLSPN CCNB1	1.33e-04	181	64	4	74311aac2fe27dc02a9be3bc20e0c7ef1c239049
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 DLC1 ADAM23 RASGRP3	1.33e-04	181	64	4	cbb530566893281289026bfd93adf721decd4ca3
ToppCell	COVID-19-Heart-EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FLT1 DLC1 PLCB1 PLCB4	1.36e-04	182	64	4	e67f3234165199085c793915ebb1f9bbd845e933
ToppCell	droplet-Heart-nan-3m-Endothelial-endothelial_cell_of_coronary_artery\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZBTB46 FLT1 RASGRP3 PLCB4	1.36e-04	182	64	4	81279877b920b5a1bc991a07d3031d6458700fe3
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_VWA2\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RGMA DLC1 ASPM PLCB4	1.36e-04	182	64	4	72e65a23cd36085bc880087d3cae92395de918a1
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ZBTB46 FLT1 PLCB4 APP	1.36e-04	182	64	4	a20017b6a4f9a6a29e090e4dbd7c02ed1495bd50
ToppCell	E18.5-samps-Endothelial-Mature_fetal_endothelial\|E18.5-samps / Age Group, Lineage, Cell class and subclass	FLT1 ADAM23 RASGRP3 ARAP2	1.36e-04	182	64	4	7af3b2029b7f55b923d5a4b764d4292f4ea48599
ToppCell	343B-Lymphocytic-NK_cells-Proliferating_NK_cell\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	ZNF862 ASPM CLSPN CCNB1	1.36e-04	182	64	4	b1e66ccd5f33b4801f1cafddf97f5fc0c6dba8d1
ToppCell	E18.5-samps-Endothelial\|E18.5-samps / Age Group, Lineage, Cell class and subclass	FLT1 ADAM23 RASGRP3 ARAP2	1.36e-04	182	64	4	e2d799e6e7526176a6fe6515b8fbe4d83d3a3ea1
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	RGMA FLT1 DLC1 PLCB1	1.36e-04	182	64	4	fbd5e332df73bf7141c822fa67b76367dc962017
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RGMA DLC1 ASPM PLCB4	1.36e-04	182	64	4	05c167158815bf25d509df59ab386e1990712765
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLT1 RASGRP3 ASPM CCNB1	1.39e-04	183	64	4	52af3c943116073c8ddd207b664342960b88929b
ToppCell	Control-Endothelial_cells-Pulmonary_venous_endothelial_cells\|Control / group, cell type (main and fine annotations)	FLT1 ADAM23 PLCB1 PLCB4	1.39e-04	183	64	4	46be9f96755c7b65aeac061d95d15abeb6466034
ToppCell	COVID-19-Endothelial_cells-Arterial_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	FLT1 TTC28 PLCB1 PLCB4	1.42e-04	184	64	4	0f19494789f38ab1a420545e15e748ca7eb345c3
ToppCell	Bac-SEP-Lymphocyte-T_NK-T_NK_proliferative\|Bac-SEP / Disease, Lineage and Cell Type	PRF1 ASPM CLSPN CCNB1	1.42e-04	184	64	4	848d05afd5a2ef61fb8a09c0f5fa2a56fd5c160b
ToppCell	droplet-Liver-HEPATOCYTES-1m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 ADAM23 RASGRP3 PLCB4	1.45e-04	185	64	4	742350093d90f96735dc73e3360cdd749bae63fd
ToppCell	COVID-cycling-\|COVID / Condition, Cell_class and T cell subcluster	STXBP5L ASPM CLSPN CCNB1	1.45e-04	185	64	4	eb74b8d36f7b749e04bc2ed4b36f7e1ac7bb6d5f
ToppCell	COVID-19-Endothelial_cells-Systemic_venous_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	FLT1 ADAM23 PLCB1 PLCB4	1.45e-04	185	64	4	f5e14181f45c37d13ee9e017a4c8bc248c353676
ToppCell	LA-07._Pericyte\|LA / Chamber and Cluster_Paper	ZBTB46 FLT1 DLC1 PLCB4	1.45e-04	185	64	4	ba5baa4d7f097108622674de5b7f4fd279843d24
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 DLC1 ADAM23 RASGRP3	1.45e-04	185	64	4	bdd2e6cb20294b39a9d856004bf57ba69cf877e2
ToppCell	COVID-cycling\|COVID / Condition, Cell_class and T cell subcluster	STXBP5L ASPM CLSPN CCNB1	1.45e-04	185	64	4	5112f966735fa48f0606adcfd5c0212ad5d3d77a
Disease	ovary epithelial cancer (is_marker_for)	BRD7 ASPM CCNB1	2.61e-06	13	63	3	DOID:2152 (is_marker_for)
Disease	AUTISM, SUSCEPTIBILITY TO, 15	CDK8 SIN3A	1.25e-04	8	63	2	C2677504
Disease	visual epilepsy (is_implicated_in)	ASPM APP	2.44e-04	11	63	2	DOID:11832 (is_implicated_in)
Disease	cancer (implicated_via_orthology)	RFK FLT1 SIN3A PIP5K1C HSP90AB3P	2.72e-04	268	63	5	DOID:162 (implicated_via_orthology)
Disease	nervousness	DENND1A MADD	5.28e-04	16	63	2	NCIT_C74532
Disease	alcohol use disorder (implicated_via_orthology)	PBRM1 BRD7 PRKACA MADD	8.12e-04	195	63	4	DOID:1574 (implicated_via_orthology)
Disease	anti-Mullerian hormone measurement	RGMA TTC28	8.32e-04	20	63	2	EFO_0004769
Disease	feeling nervous measurement	PBRM1 DENND1A MADD	8.65e-04	87	63	3	EFO_0009597
Disease	Left Ventricle Remodeling	SLC9A1 OPA1	9.18e-04	21	63	2	C0600520
Disease	Ventricular Remodeling	SLC9A1 OPA1	9.18e-04	21	63	2	C0600519
Disease	Headache, type 2 diabetes mellitus	DENND1A MSL2	1.10e-03	23	63	2	HP_0002315, MONDO_0005148
Disease	Intrahepatic Cholangiocarcinoma	PBRM1 PRKACA	1.20e-03	24	63	2	C0345905
Disease	Extrahepatic Cholangiocarcinoma	PBRM1 PRKACA	1.20e-03	24	63	2	C3805278
Disease	Cholangiocarcinoma	PBRM1 PRKACA	1.41e-03	26	63	2	C0206698
Disease	caudate volume change measurement, age at assessment	DLC1 UBR3	1.52e-03	27	63	2	EFO_0008007, EFO_0021491
Disease	transforming growth factor beta measurement	RGMA DLC1	1.52e-03	27	63	2	EFO_0004818
Disease	congestive heart failure (is_implicated_in)	SLC9A1 PRKACA	1.52e-03	27	63	2	DOID:6000 (is_implicated_in)
Disease	opioid dependence	RGMA DLC1 C9 DENND1A	1.67e-03	237	63	4	EFO_0005611
Disease	Mental Retardation, X-Linked	ZNF711 ZNF41	1.76e-03	29	63	2	C1136249

Protein segments in the cluster

Peptide	Gene	Start	Entry
EKHRHSKMKIAYKDT	nan	71	A8MVM7
LELMIVNDHKTYKKH	ADAM23	301	O75077
SYHTKVSTVHIMKKR	AGAP9	236	Q5VTM2
MGKKHKKHKSDKHLY	BRD7	1	Q9NPI1
VMLKKKQYTSIHHGV	APP	721	P05067
KKEDMMFHKIYIQKH	ADCY6	361	O43306
YKDVKSSKHDKMFSL	ARAP2	1471	Q8WZ64
SLYKLTAHKHKMNTE	ASPM	3401	Q8IZT6
TAHKHKMNTERILYK	ASPM	3406	Q8IZT6
HKLSVSNMVHTAKKK	RAB3GAP1	376	Q15042
FFQKAKKEHKMEESH	FMN1	1306	Q68DA7
IKKIFYMKKAEIEHH	PBRM1	276	Q86U86
VKHKETGNHYAMKIL	PRKACA	61	P17612
IKEVVSHKYKTPMAH	MADD	1601	Q8WXG6
KILKYVSHMKETQKS	HSP90AB3P	341	Q58FF7
KQHGKKDSKITDHFM	PARG	401	Q86W56
EKKKKHKMTASFHQT	PRF1	281	P14222
KKKKHFSETEASYIM	RPS6KA5	511	O75582
KSMKKSHEHGSKKSH	MSL2	406	Q9HCI7
HHRKLKKSLIDMYSE	OPA1	256	O60313
KHMTVKNKYATSKHA	CCNB1	396	P14635
KGHAHKATEALKKMY	GDE1	176	Q9NZC3
HYLKGLKIEKMSHSR	IFIT1B	401	Q5T764
AMKTVYKFAKDHAKM	DENND1A	426	Q8TEH3
YMEKHKVKPDSKAFH	CDK8	296	P49336
KKKYKKVVSDDALMH	SBNO1	1251	A3KN83
KKLSMYGVDLHHAKD	EPB41L3	291	Q9Y2J2
YSSKKEKMFLHVKGE	C9	286	P02748
AAEHYKLQMEKAKTH	NUMA1	1606	Q14980
EKKKLNTDLYHMKHS	GOLGA8A	161	A7E2F4
KKTTYHTMVDLKDLK	TRIM45	166	Q9H8W5
SLKKKHAKEHSTMQK	PLCB4	941	Q15147
KLKYEHHLKESLKQM	TAF1D	166	Q9H5J8
VKMHLKFDLKGSTYK	PIP5K1C	246	O60331
HTFPKMKSKFHDKAA	RASGRP3	631	Q8IV61
KEDKYKIKQIMHHFI	SIN3A	806	Q96ST3
DIFKKKKHVLSYKSH	SLC5A8	566	Q8N695
AIKKMSYSGKQTHEK	TAOK3	51	Q9H2K8
HKVFYKSEDKMKIHS	PHAF1	256	Q9BSU1
VKMLHSNKDKLHLYE	RGMA	401	Q96B86
MESLKLKSSHHSKHK	DLC1	671	Q96QB1
AFSKHAHELMLKYKD	STXBP5L	1166	Q9Y2K9
MALLKSSKYQSSHHK	CLSPN	331	Q9HAW4
LIVSLYTHHKKMKVH	TAS2R5	191	Q9NYW4
GFMHMKLSRTKEHKY	SHF	366	Q7M4L6
LTAMSYTILKLHKKH	USP6NL	296	Q92738
MHYLKKHNYSKEKVL	RLF	1146	Q13129
KAFAHMSVLIKHEKT	ZNF577	361	Q9BSK1
RASLKYHMTKHKAET	ZNF276	536	Q8N554
ISHKSHTTIKYFLKM	SLC9A1	371	P19634
YKNTKKSMETHIMHT	RFK	71	Q969G6
HYKEMKDLVKRHHKK	PLCB1	926	Q9NQ66
KVETLKYHAKSKAHM	ZNF862	186	O60290
MKGDYDTALKLHKTH	TTC28	486	Q96AY4
SFSKNSMVIKHKKVY	ZNF471	186	Q9BX82
KHQKMHSGEKRYKAS	ZNF41	806	P51814
KAFSHKEKLIKHYKI	ZNF569	221	Q5MCW4
QHYAFIMKTLKKSHE	UBR3	421	Q6ZT12
FKRKDYLKQHMKTHA	GTF3A	226	Q92664
HYSISKQKMAITKEH	FLT1	601	P17948
LKKHMKTHTGRKIYQ	ZNF711	691	Q9Y462
KKFYTMAHVRKHMVA	ZNF652	336	Q9Y2D9
DLSVHMIKTKHYQKV	TSHZ1	321	Q6ZSZ6
VHHILQDMYKTKKKK	THUMPD1	141	Q9NXG2
MKRHTLVHSKDKKYV	ZBTB46	461	Q86UZ6
KLYKHEIHKLKDMTC	MXRA5	261	Q9NR99