Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	peptidyltransferase activity	GGTLC2 GGT3P	2.24e-04	6	78	2	GO:0000048
GeneOntologyMolecularFunction	leukotriene-C(4) hydrolase	GGTLC2 GGT3P	2.24e-04	6	78	2	GO:0002951
GeneOntologyMolecularFunction	leukotriene C4 gamma-glutamyl transferase activity	GGTLC2 GGT3P	4.15e-04	8	78	2	GO:0103068
GeneOntologyMolecularFunction	glutathione hydrolase activity	GGTLC2 GGT3P	5.33e-04	9	78	2	GO:0036374
GeneOntologyCellularComponent	junctional membrane complex	JPH4 RYR1 JPH3	3.67e-06	9	75	3	GO:0030314
GeneOntologyCellularComponent	junctional sarcoplasmic reticulum membrane	JPH4 RYR1 JPH3	5.23e-06	10	75	3	GO:0014701
GeneOntologyCellularComponent	sarcoplasmic reticulum	JPH4 FSD2 HAX1 RYR1 JPH3	1.61e-05	88	75	5	GO:0016529
GeneOntologyCellularComponent	sarcoplasm	JPH4 FSD2 HAX1 RYR1 JPH3	5.62e-05	114	75	5	GO:0016528
GeneOntologyCellularComponent	sarcoplasmic reticulum membrane	JPH4 RYR1 JPH3	5.65e-04	45	75	3	GO:0033017
Domain	Junctophilin	JPH4 JPH3	9.00e-05	4	73	2	IPR017191
Domain	GGT_peptidase	GGTLC2 GGT3P	3.12e-04	7	73	2	IPR000101
Domain	G_GLU_TRANSPEPTIDASE	GGTLC2 GGT3P	3.12e-04	7	73	2	PS00462
Domain	G_glu_transpept	GGTLC2 GGT3P	3.12e-04	7	73	2	PF01019
Domain	MORN	JPH4 JPH3	1.33e-03	14	73	2	SM00698
Domain	MORN	JPH4 JPH3	1.53e-03	15	73	2	IPR003409
Domain	MORN	JPH4 JPH3	1.53e-03	15	73	2	PF02493
Domain	FCH	PACSIN3 FCHSD1	3.31e-03	22	73	2	PF00611
Domain	FCH	PACSIN3 FCHSD1	3.31e-03	22	73	2	SM00055
Domain	FCH_dom	PACSIN3 FCHSD1	3.61e-03	23	73	2	IPR001060
Domain	F_BAR	PACSIN3 FCHSD1	4.26e-03	25	73	2	IPR031160
Domain	F_BAR	PACSIN3 FCHSD1	4.26e-03	25	73	2	PS51741
Pubmed	New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes.	JPH4 RYR1 JPH3	2.26e-06	12	77	3	19095005
Pubmed	Functional uncoupling between Ca2+ release and afterhyperpolarization in mutant hippocampal neurons lacking junctophilins.	JPH4 JPH3	4.84e-06	2	77	2	16809425
Pubmed	Abnormal features in mutant cerebellar Purkinje cells lacking junctophilins.	JPH4 JPH3	1.45e-05	3	77	2	17904530
Pubmed	Coexpression of junctophilin type 3 and type 4 in brain.	JPH4 JPH3	1.45e-05	3	77	2	14559359
Pubmed	Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity.	JPH4 JPH3	2.89e-05	4	77	2	17347645
Pubmed	Lung lining fluid glutathione attenuates IL-13-induced asthma.	GGTLC2 GGT3P	4.82e-05	5	77	2	18063838
Pubmed	Gamma-glutamyltranspeptidase knockout mice as a model for understanding the consequences of diminished glutathione on T cell-dependent immune responses.	GGTLC2 GGT3P	4.82e-05	5	77	2	10940879
Pubmed	Liver-Specific Overexpression of Gamma-Glutamyltransferase Ameliorates Insulin Sensitivity of Male C57BL/6 Mice.	GGTLC2 GGT3P	4.82e-05	5	77	2	28660214
Pubmed	Bleomycin-induced pulmonary fibrosis is attenuated in gamma-glutamyl transpeptidase-deficient mice.	GGTLC2 GGT3P	4.82e-05	5	77	2	12468440
Pubmed	N-acetyl-cysteine prevents age-related hearing loss and the progressive loss of inner hair cells in γ-glutamyl transferase 1 deficient mice.	GGTLC2 GGT3P	4.82e-05	5	77	2	26977590
Pubmed	Gamma-glutamyl transferase deficiency results in lung oxidant stress in normoxia.	GGTLC2 GGT3P	4.82e-05	5	77	2	12225953
Pubmed	Identification of a sixth promoter that directs the transcription of gamma-glutamyl transpeptidase type III RNA in mouse.	GGTLC2 GGT3P	4.82e-05	5	77	2	7775425
Pubmed	Cataract development in gamma-glutamyl transpeptidase-deficient mice.	GGTLC2 GGT3P	4.82e-05	5	77	2	11095909
Pubmed	Expression of gamma-glutamyl transpeptidase in midgestation mouse yolk sac and mouse visceral yolk sac carcinoma cells.	GGTLC2 GGT3P	4.82e-05	5	77	2	7641802
Pubmed	Phenotypic characterization of Ggt1(dwg/dwg) mice,a mouse model for hereditary γ-glutamyltransferase deficiency.	GGTLC2 GGT3P	4.82e-05	5	77	2	23615310
Pubmed	Cloning of cDNA and genomic structure of the mouse gamma-glutamyl transpeptidase-encoding gene.	GGTLC2 GGT3P	4.82e-05	5	77	2	8566783
Pubmed	Therapeutic Effect of GGsTop, Selective Gamma-glutamyl Transpeptidase Inhibitor, on a Mouse Model of 5-Fluorouracil-induced Oral Mucositis.	GGTLC2 GGT3P	4.82e-05	5	77	2	30591459
Pubmed	Mice with genetic gamma-glutamyl transpeptidase deficiency exhibit glutathionuria, severe growth failure, reduced life spans, and infertility.	GGTLC2 GGT3P	4.82e-05	5	77	2	9139708
Pubmed	Analysis of site-specific glycosylation of renal and hepatic γ-glutamyl transpeptidase from normal human tissue.	GGTLC2 GGT3P	4.82e-05	5	77	2	20622017
Pubmed	The mouse skin carcinogenesis model.	GGTLC2 GGT3P	4.82e-05	5	77	2	9627710
Pubmed	Accelerated methylmercury elimination in gamma-glutamyl transpeptidase-deficient mice.	GGTLC2 GGT3P	4.82e-05	5	77	2	9546365
Pubmed	Gamma-glutamyl transpeptidase and its role in melanogenesis: redox reactions and regulation of tyrosinase.	GGTLC2 GGT3P	4.82e-05	5	77	2	12453183
Pubmed	In vivo reversal of glutathione deficiency and susceptibility to in vivo dexamethasone-induced apoptosis by N-acetylcysteine and L-2-oxothiazolidine-4-carboxylic acid, but not ascorbic acid, in thymocytes from gamma-glutamyltranspeptidase-deficient knockout mice.	GGTLC2 GGT3P	4.82e-05	5	77	2	11795900
Pubmed	gamma-Glutamyl transpeptidase. What does the organization and expression of a multipromoter gene tell us about its functions?	GGTLC2 GGT3P	4.82e-05	5	77	2	7485380
Pubmed	gamma-glutamyltranspeptidase-deficient knockout mice as a model to study the relationship between glutathione status, mitochondrial function, and cellular function.	GGTLC2 GGT3P	4.82e-05	5	77	2	11003618
Pubmed	Accumulation of DNA damage in the organs of mice deficient in gamma-glutamyltranspeptidase.	GGTLC2 GGT3P	4.82e-05	5	77	2	10751614
Pubmed	Gamma-glutamyl transpeptidase gene organization and expression: a comparative analysis in rat, mouse, pig and human species.	GGTLC2 GGT3P	4.82e-05	5	77	2	10392451
Pubmed	Type VI RNA is the major gamma-glutamyl transpeptidase RNA in the mouse small intestine.	GGTLC2 GGT3P	4.82e-05	5	77	2	7523374
Pubmed	Immunocytochemical localization of gamma-glutamyltranspeptidase during fetal development of mouse kidney.	GGTLC2 GGT3P	4.82e-05	5	77	2	2891746
Pubmed	Cardio-reno-hepatic interactions in acute heart failure: the role of γ-glutamyl transferase.	GGTLC2 GGT3P	4.82e-05	5	77	2	24698228
Pubmed	Hyperoxia-induced lung injury in gamma-glutamyl transferase deficiency is associated with alterations in nitrosative and nitrative stress.	GGTLC2 GGT3P	4.82e-05	5	77	2	19850887
Pubmed	Junctophilin Proteins Tether a Cav1-RyR2-KCa3.1 Tripartite Complex to Regulate Neuronal Excitability.	JPH4 JPH3	4.82e-05	5	77	2	31461656
Pubmed	Inhibiting lung lining fluid glutathione metabolism with GGsTop as a novel treatment for asthma.	GGTLC2 GGT3P	4.82e-05	5	77	2	25132819
Pubmed	Characterization of the dwg mutations: dwg and dwg(Bayer) are new mutant alleles of the Ggt1 gene.	GGTLC2 GGT3P	4.82e-05	5	77	2	19760322
Pubmed	gamma-Glutamyl transferase (GGT) deficiency in the GGTenu1 mouse results from a single point mutation that leads to a stop codon in the first coding exon of GGT mRNA.	GGTLC2 GGT3P	4.82e-05	5	77	2	10474818
Pubmed	Reversible skeletal abnormalities in gamma-glutamyl transpeptidase-deficient mice.	GGTLC2 GGT3P	4.82e-05	5	77	2	12810527
Pubmed	Growth retardation and cysteine deficiency in gamma-glutamyl transpeptidase-deficient mice.	GGTLC2 GGT3P	4.82e-05	5	77	2	8755578
Pubmed	Reproductive defects in gamma-glutamyl transpeptidase-deficient mice.	GGTLC2 GGT3P	4.82e-05	5	77	2	11089562
Pubmed	Gamma-glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D(4) formation in vivo.	GGTLC2 GGT3P	7.22e-05	6	77	2	12163373
Pubmed	Gamma-glutamyltranspeptidase stimulates receptor activator of nuclear factor-kappaB ligand expression independent of its enzymatic activity and serves as a pathological bone-resorbing factor.	GGTLC2 GGT3P	7.22e-05	6	77	2	14634009
Pubmed	Overexpression of gamma-glutamyltransferase in transgenic mice accelerates bone resorption and causes osteoporosis.	GGTLC2 GGT3P	7.22e-05	6	77	2	17363454
Pubmed	Six mRNAs with different 5' ends are encoded by a single gamma-glutamyltransferase gene in mouse.	GGTLC2 GGT3P	7.22e-05	6	77	2	8101000
Pubmed	Four distinct membrane-bound dipeptidase RNAs are differentially expressed and show discordant regulation with gamma-glutamyl transpeptidase.	GGTLC2 GGT3P	7.22e-05	6	77	2	8663190
Pubmed	Mapping of human gamma-glutamyl transpeptidase genes on chromosome 22 and other human autosomes.	GGTLC2 GGT3P	7.22e-05	6	77	2	8104871
Pubmed	Disruption of gamma-glutamyl leukotrienase results in disruption of leukotriene D(4) synthesis in vivo and attenuation of the acute inflammatory response.	GGTLC2 GGT3P	7.22e-05	6	77	2	11463821
Pubmed	Ablation of Mrds1/Ofcc1 induces hyper-γ-glutamyl transpeptidasemia without abnormal head development and schizophrenia-relevant behaviors in mice.	GGTLC2 GGT3P	7.22e-05	6	77	2	22242126
Pubmed	Effect of atorvastatin on the expression of gamma-glutamyl transferase in aortic atherosclerotic plaques of apolipoprotein E-knockout mice.	GGTLC2 GGT3P	7.22e-05	6	77	2	25326709
Pubmed	γ-Glutamyltranspeptidase is an endogenous activator of Toll-like receptor 4-mediated osteoclastogenesis.	GGTLC2 GGT3P	1.01e-04	7	77	2	27775020
Pubmed	Defective epidermal growth factor gene expression in mice with polycystic kidney disease.	GGTLC2 GGT3P	1.01e-04	7	77	2	1968405
Pubmed	Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation.	GGTLC2 GGT3P	1.01e-04	7	77	2	32284594
Pubmed	m6A eraser FTO modulates autophagy by targeting SQSTM1/P62 in the prevention of canagliflozin against renal fibrosis.	GGTLC2 GGT3P	1.01e-04	7	77	2	36685533
Pubmed	Renalase regulates renal dopamine and phosphate metabolism.	GGTLC2 GGT3P	2.15e-04	10	77	2	23863468
Pubmed	Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.	FRMD4A TUT1 KLC4 PLOD2 SRSF9 ARID3B	2.32e-04	390	77	6	17643375
Pubmed	The human gamma-glutamyltransferase gene family.	GGTLC2 GGT3P	4.33e-04	14	77	2	18357469
Pubmed	PDZ-Containing Proteins Targeted by the ACE2 Receptor.	SHANK2 SHROOM2	4.99e-04	15	77	2	34835087
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	RCAN1 APC2 ZBTB4 FIP1L1 SPOCK2 SHROOM2 NSUN2 PRRC2A PREPL JPH3	5.30e-04	1285	77	10	35914814
Pubmed	Gene dosage in the developing and adult brain in a mouse model of 22q11 deletion syndrome.	GGTLC2 GGT3P	7.23e-04	18	77	2	17097888
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	SHANK2 TSKS SHROOM2 RYR1 FOXJ1	8.32e-04	329	77	5	17474147
Pubmed	Unassembled CD147 is an endogenous endoplasmic reticulum-associated degradation substrate.	OS9 PLOD2	9.89e-04	21	77	2	23097496
Pubmed	DNGR-1-tracing marks an ependymal cell subset with damage-responsive neural stem cell potential.	PKD2L1 FOXJ1	1.09e-03	22	77	2	35998585
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	PGRMC2 PANK4 PACSIN3 OS9 HAX1 EIF3J PLOD2 NSUN2 SRSF9 PRRC2A	1.26e-03	1440	77	10	30833792
Pubmed	Insights into the Role of a Cardiomyopathy-Causing Genetic Variant in ACTN2.	RCAN1 WEE1	1.64e-03	27	77	2	36899856
Pubmed	Hepatoblast-like cells enriched from mouse embryonic stem cells in medium without glucose, pyruvate, arginine, and tyrosine.	GGTLC2 GGT3P	1.64e-03	27	77	2	18478268
Pubmed	Cell-surface proteomics identifies lineage-specific markers of embryo-derived stem cells.	GGTLC2 GGT3P	1.89e-03	29	77	2	22424930
Pubmed	Identification of interaction partners for individual SH3 domains of Fas ligand associated members of the PCH protein family in T lymphocytes.	PACSIN3 FCHSD1	2.16e-03	31	77	2	19041431
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	CD177 CLEC11A SIGLEC6 FIZ1 KLK9 IRGQ FBXO17 CCER2 TSKS RYR1	3.41e-05	1192	78	10	chr19q13
Cytoband	19q13.3	CLEC11A SIGLEC6 TSKS	3.79e-04	82	78	3	19q13.3
GeneFamily	CD molecules\|Gamma-glutamyltransferases	GGTLC2 GGT3P	5.07e-04	13	47	2	564
GeneFamily	Rho GTPase activating proteins\|F-BAR domain containing	PACSIN3 FCHSD1	1.62e-03	23	47	2	1288
CoexpressionAtlas	FacebaseRNAseq_e9.5_Maxillary Arch_top-relative-expression-ranked_1000_k-means-cluster#2	PPP1R26 CLEC11A ZBTB4 PACSIN3 SPOCK2 ARID3B	4.77e-06	121	76	6	Facebase_RNAseq_e9.5_Maxillary Arch_1000_K2
CoexpressionAtlas	FacebaseRNAseq_e9.5_Facial Mesenchyne_top-relative-expression-ranked_1000_k-means-cluster#1	PPP1R26 CLEC11A ZBTB4 PACSIN3 SPOCK2 ARID3B	5.76e-06	125	76	6	Facebase_RNAseq_e9.5_Facial Mesenchyne_1000_K1
CoexpressionAtlas	FacebaseRNAseq_e8.5_Non-Floor Plate Neural Epithelium_top-relative-expression-ranked_1000_k-means-cluster#1	CLEC11A ZBTB4 PACSIN3 SPOCK2 ARID3B	8.63e-05	125	76	5	Facebase_RNAseq_e8.5_Non-Floor Plate Neural Epithelium_1000_K1
Disease	aflatoxins-related hepatocellular carcinoma (biomarker_via_orthology)	GGTLC2 GGT3P	1.40e-04	7	77	2	DOID:5022 (biomarker_via_orthology)
Disease	alcohol dependence (biomarker_via_orthology)	GGTLC2 GGT3P	1.86e-04	8	77	2	DOID:0050741 (biomarker_via_orthology)
Disease	hemifacial microsomia	FRMD4A ARID3B	1.12e-03	19	77	2	MONDO_0015398

Protein segments in the cluster

Peptide	Gene	Start	Entry
GGLAWSDDADGGRGR	ARID3B	186	Q8IVW6
GAGWAFGEAEGASGL	EXOC3L4	261	Q17RC7
AGAGVGELGAARAWE	ADAD2	71	Q8NCV1
QGREDPSWEGGALGD	LINC00588	61	Q9Y4M8
VGSGGDGERWGSDRG	ACBD5	426	Q5T8D3
RGEGLGVALVESGWG	APBA3	401	O96018
MARGAEGGRGDAGWG	GLDN	1	Q6ZMI3
EGGRGDAGWGLRGAL	GLDN	6	Q6ZMI3
EGGGAEGLESLTWGV	CD177	406	Q8N6Q3
GWRESLGLGEGAGPE	DDN	411	O94850
SGGAEDEGEAEAGWI	ATP2B3	141	Q16720
GDRLPGGRGDQAWDV	IGDCC4	676	Q8TDY8
LSGAAEADEGGGDWS	RCAN1	36	P53805
IGWGTDQGIGGFGEE	IER3IP1	31	Q9Y5U9
ERKSGEAGWGTGELG	ODF4	26	Q2M2E3
EAGWGTGELGQDGRL	ODF4	31	Q2M2E3
DGAEGGGKRGEAGWE	NSUN2	21	Q08J23
GGEDASVAVEWSGDG	KLC4	531	Q9NSK0
GGWAAASDSRKGGEP	GGT3P	551	A6NGU5
GWERGGDRCDAPGGD	OTUD1	236	Q5VV17
EEEEEGGSWGRGNPR	HAX1	36	O00165
PWEVGAGAGEERALG	GPR179	1706	Q6PRD1
RKVGGGGTAGGDRWE	EIF3J	26	O75822
GGTAGGDRWEGEDED	EIF3J	31	O75822
AAGQGSGEGCGLWEE	FAM184B	796	Q9ULE4
DGGCYVGGWEAGRAH	JPH4	11	Q96JJ6
ESPGDAGAAAEGGGW	PGRMC2	26	O15173
AGAAAEGGGWAAAAL	PGRMC2	31	O15173
GTGGDEEEEWLYGGP	FIP1L1	16	Q6UN15
GAISRGLGGWEAEAG	EHBP1L1	551	Q8N3D4
GLGGWEAEAGGSGDL	EHBP1L1	556	Q8N3D4
NVEGGWAEGGRGVSI	LCT	396	P09848
GGWAAASDSRKGGEP	GGTLC2	201	Q14390
GWDSGRAAVAAVVGG	IFI27L1	6	Q96BM0
GVSPGTGGREGAEWR	INSM2	81	Q96T92
EDCGGWDLGGAEERP	ECEL1	206	O95672
QGEEWRGGDGINSIG	PLOD2	71	O00469
EDRFEWVGGSSIGGG	PANK4	206	Q9NVE7
ADVLGVADGVGGWRD	PPTC7	71	Q8NI37
EQGFRGWEVEHGGNG	FBXO17	116	Q96EF6
DGVDDGFWRGEFGGR	FCHSD1	581	Q86WN1
ESWRGGGGDEGDTGR	FRMD4A	881	Q9P2Q2
DWLQARDGGPEGGGA	APC2	386	O95996
LGGDRSLWQGAERGG	CCER2	191	I3L3R5
SWDMDGLRADGGGAG	HOXD13	6	P35453
EATGEAGWGAGEGRL	FOXJ1	256	Q92949
GAGAGLGSWGLAEAA	FIZ1	176	Q96SL8
VWQGGAPREDGGARG	IFRD2	11	Q12894
WDGNSEEILGGAGGS	ITIH6	1041	Q6UXX5
GLWEGGRGSCQGDSG	KLK9	191	Q9UKQ9
GWGLGAGEEAEGDED	RYR1	4611	P21817
VEARLGAWAGEGTAG	IRGQ	556	Q8WZA9
DAGGEALGGSFWEAG	PACSIN3	6	Q9UKS6
GGAALSGGEVESGWR	ARHGAP30	216	Q7Z6I6
EDGARAWNGSAEGPG	NYAP1	651	Q6ZVC0
MSGWADERGGEGDGR	SRSF9	1	Q13242
VFDWAGASDGGGGEA	SLC9A6	36	Q92581
AAGGVLGGWLVDRAG	SLC2A8	81	Q9NY64
AAEAEDLGFGGWGSA	FSD2	126	A1L4K1
TWRDGGGRGPDELEG	PRRC2A	206	P48634
EGRAGGVLGAVWGAS	SIGLEC6	341	O43699
AEDGTGRWRAGLGGG	SHROOM2	656	Q13796
WRGGVGSERDKGSEG	PPP1R26	1051	Q5T8A7
AAETWIDGGGGVGAD	TACR3	6	P29371
WGSPGGEGTGDLDEF	OS9	651	Q13438
LSIGEGGFWEGSARG	SHANK2	556	Q9UPX8
GGWDSSGCYVEEGDG	ADGRF5	966	Q8IZF2
AGAGEALEGVLGQGW	APOBR	776	Q0VD83
SREGGPWGGRVEAEE	APOBR	831	Q0VD83
GARGAEREWEGGWGG	CLEC11A	21	Q9Y240
DGAAGAGWVRGGAAR	CNNM3	41	Q8NE01
RWISGGGGGASPEEA	USP51	16	Q70EK9
GADEAGGGAEGDSWE	WEE1	101	P30291
GGGAEGDSWEEEGFG	WEE1	106	P30291
EGAGGGAGTRAGWLA	TUT1	791	Q9H6E5
GEAGVAGAGLEAWRH	TUG1	106	A0A6I8PU40
GISRLQGLGEGGDAW	ZBTB4	171	Q9P1Z0
ALAWQGEEDAGGGGE	SMIM44	101	A0A286YF18
GGGELGLQWHADGRL	PREPL	511	Q4J6C6
GGLGGRVDGFLGQWE	TSKS	356	Q9UJT2
SGAEGGDLTAWGEDG	WDR53	26	Q7Z5U6
SGPEAARAGGWVSGE	PKD2L1	691	Q9P0L9
GFSGDFGSGVGWEDE	SPOCK2	381	Q92563
VALPGSGAEGDGGWR	JMJD8	16	Q96S16
WGEEQAGGSRGVRSG	JPH3	531	Q8WXH2