Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	medium-chain fatty acid omega-hydroxylase activity	CYP4A11 CYP4A22	6.65e-06	2	52	2	GO:0140981
GeneOntologyMolecularFunction	16-hydroxypalmitate dehydrogenase activity	CYP4A11 CYP4A22	6.65e-06	2	52	2	GO:0103002
GeneOntologyMolecularFunction	leukotriene-B4 20-monooxygenase activity	CYP4A11 CYP4A22	1.39e-04	7	52	2	GO:0050051
GeneOntologyMolecularFunction	alkane 1-monooxygenase activity	CYP4A11 CYP4A22	1.39e-04	7	52	2	GO:0018685
GeneOntologyMolecularFunction	arachidonate omega-hydroxylase activity	CYP4A11 CYP4A22	2.95e-04	10	52	2	GO:0052869
GeneOntologyMolecularFunction	fatty acid omega-hydroxylase activity	CYP4A11 CYP4A22	2.95e-04	10	52	2	GO:0120250
GeneOntologyMolecularFunction	long-chain fatty acid omega-hydroxylase activity	CYP4A11 CYP4A22	2.95e-04	10	52	2	GO:0102033
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	CYP4A11 CYP4A22	5.09e-04	13	52	2	GO:0016713
GeneOntologyMolecularFunction	arachidonate binding	CYP4A11 CYP4A22	6.83e-04	15	52	2	GO:0050544
GeneOntologyMolecularFunction	icosanoid binding	CYP4A11 CYP4A22	7.80e-04	16	52	2	GO:0050542
GeneOntologyMolecularFunction	icosatetraenoic acid binding	CYP4A11 CYP4A22	7.80e-04	16	52	2	GO:0050543
GeneOntologyMolecularFunction	arachidonate epoxygenase activity	CYP4A11 CYP4A22	1.77e-03	24	52	2	GO:0008392
GeneOntologyMolecularFunction	arachidonate monooxygenase activity	CYP4A11 CYP4A22	2.24e-03	27	52	2	GO:0008391
GeneOntologyMolecularFunction	long-chain fatty acid binding	CYP4A11 CYP4A22	2.41e-03	28	52	2	GO:0036041
GeneOntologyMolecularFunction	deaminase activity	APOBEC3D ADA2	3.54e-03	34	52	2	GO:0019239
GeneOntologyMolecularFunction	aromatase activity	CYP4A11 CYP4A22	3.75e-03	35	52	2	GO:0070330
GeneOntologyMolecularFunction	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	APOBEC3D ADA2	3.96e-03	36	52	2	GO:0016814
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	CHD9 CHD6	4.18e-03	37	52	2	GO:0140658
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	RTEL1 CHD9 CHD6	4.42e-03	127	52	3	GO:0008094
GeneOntologyBiologicalProcess	lauric acid metabolic process	CYP4A11 CYP4A22	1.80e-05	3	51	2	GO:0048252
GeneOntologyBiologicalProcess	microtubule cytoskeleton organization	SPATA7 CEP250 KATNB1 OBSL1 TLE6 UXT CUL7 SPAG16 CEP63	5.98e-05	720	51	9	GO:0000226
GeneOntologyCellularComponent	3M complex	OBSL1 CUL7	6.04e-05	5	52	2	GO:1990393
GeneOntologyCellularComponent	rod photoreceptor outer segment	SPATA7 GUCY2F	2.16e-04	9	52	2	GO:0120200
GeneOntologyCellularComponent	nuclear ubiquitin ligase complex	PHC3 CUL7 PHC2	2.47e-04	49	52	3	GO:0000152
Domain	Znf_FCS	PHC3 PHC2	7.56e-05	5	52	2	IPR012313
Domain	BRK	CHD9 CHD6	1.13e-04	6	52	2	SM00592
Domain	BRK_domain	CHD9 CHD6	1.13e-04	6	52	2	IPR006576
Domain	BRK	CHD9 CHD6	1.13e-04	6	52	2	PF07533
Domain	ZF_FCS	PHC3 PHC2	1.13e-04	6	52	2	PS51024
Domain	Chromo_domain	CHD9 CHD6	2.02e-03	24	52	2	IPR023780
Domain	Chromo	CHD9 CHD6	2.37e-03	26	52	2	PF00385
Domain	CHROMO_2	CHD9 CHD6	2.74e-03	28	52	2	PS50013
Domain	CHROMO_1	CHD9 CHD6	2.74e-03	28	52	2	PS00598
Domain	SNF2_N	CHD9 CHD6	3.57e-03	32	52	2	PF00176
Domain	SNF2_N	CHD9 CHD6	3.57e-03	32	52	2	IPR000330
Domain	Spectrin/alpha-actinin	AKAP6 PLEC	3.57e-03	32	52	2	IPR018159
Domain	SPEC	AKAP6 PLEC	3.57e-03	32	52	2	SM00150
Domain	Chromodomain-like	CHD9 CHD6	3.57e-03	32	52	2	IPR016197
Domain	CHROMO	CHD9 CHD6	3.80e-03	33	52	2	SM00298
Domain	Chromo/shadow_dom	CHD9 CHD6	3.80e-03	33	52	2	IPR000953
Domain	Kinase-like_dom	GUCY2F HIPK2 PKDCC CHD9 ULK1 MAP3K4	3.81e-03	542	52	6	IPR011009
Domain	Pkinase	GUCY2F HIPK2 PKDCC ULK1 MAP3K4	4.07e-03	381	52	5	PF00069
Domain	DNA/RNA_helicase_DEAH_CS	RTEL1 CHD6	4.27e-03	35	52	2	IPR002464
Domain	DEAH_ATP_HELICASE	RTEL1 CHD6	5.01e-03	38	52	2	PS00690
Domain	Cyt_P450_E_grp-I	CYP4A11 CYP4A22	6.97e-03	45	52	2	IPR002401
Domain	Cyt_P450_CS	CYP4A11 CYP4A22	9.57e-03	53	52	2	IPR017972
Domain	CYTOCHROME_P450	CYP4A11 CYP4A22	1.10e-02	57	52	2	PS00086
Pathway	REACTOME_RUNX1_INTERACTS_WITH_CO_FACTORS_WHOSE_PRECISE_EFFECT_ON_RUNX1_TARGETS_IS_NOT_KNOWN	PHC3 HIPK2 PHC2	7.29e-05	34	34	3	MM15531
Pathway	REACTOME_RUNX1_INTERACTS_WITH_CO_FACTORS_WHOSE_PRECISE_EFFECT_ON_RUNX1_TARGETS_IS_NOT_KNOWN	PHC3 HIPK2 PHC2	9.42e-05	37	34	3	M27797
Pathway	REACTOME_SUMOYLATION_OF_TRANSCRIPTION_COFACTORS	PHC3 HIPK2 PHC2	1.19e-04	40	34	3	MM15000
Pathway	REACTOME_SUMOYLATION_OF_TRANSCRIPTION_COFACTORS	PHC3 HIPK2 PHC2	1.59e-04	44	34	3	M27295
Pathway	WP_EICOSANOID_METABOLISM_VIA_CYTOCHROME_P450_MONOOXYGENASES_PATHWAY	CYP4A11 CYP4A22	2.01e-04	9	34	2	M39819
Pathway	REACTOME_SYNTHESIS_OF_16_20_HYDROXYEICOSATETRAENOIC_ACIDS_HETE	CYP4A11 CYP4A22	3.06e-04	11	34	2	MM14863
Pathway	REACTOME_EICOSANOIDS	CYP4A11 CYP4A22	3.67e-04	12	34	2	M27129
Pathway	REACTOME_MISCELLANEOUS_SUBSTRATES	CYP4A11 CYP4A22	3.67e-04	12	34	2	M27128
Pathway	REACTOME_EICOSANOIDS	CYP4A11 CYP4A22	3.67e-04	12	34	2	MM14845
Pathway	WP_EICOSANOID_METABOLISM_VIA_CYTOCHROME_P450_MONOOXYGENASES	CYP4A11 CYP4A22	5.05e-04	14	34	2	MM15842
Pathway	REACTOME_FATTY_ACIDS	CYP4A11 CYP4A22	5.81e-04	15	34	2	M27126
Pathway	REACTOME_SUMOYLATION_OF_DNA_METHYLATION_PROTEINS	PHC3 PHC2	6.63e-04	16	34	2	M27403
Pathway	REACTOME_MISCELLANEOUS_SUBSTRATES	CYP4A11 CYP4A22	8.43e-04	18	34	2	MM14843
Pathway	REACTOME_FATTY_ACIDS	CYP4A11 CYP4A22	8.43e-04	18	34	2	MM14841
Pathway	REACTOME_SYNTHESIS_OF_LEUKOTRIENES_LT_AND_EOXINS_EX	CYP4A11 CYP4A22	1.15e-03	21	34	2	M27137
Pathway	REACTOME_SYNTHESIS_OF_LEUKOTRIENES_LT_AND_EOXINS_EX	CYP4A11 CYP4A22	1.64e-03	25	34	2	MM14858
Pathway	KEGG_MEDICUS_REFERENCE_DEUBIQUITINATION_OF_H2AK119	PHC3 PHC2	1.77e-03	26	34	2	M47923
Pathway	WP_EICOSANOID_METABOLISM_VIA_LIPOOXYGENASES_LOX	CYP4A11 CYP4A22	2.20e-03	29	34	2	M39858
Pubmed	The rat clofibrate-inducible CYP4A subfamily. II. cDNA sequence of IVA3, mapping of the Cyp4a locus to mouse chromosome 4, and coordinate and tissue-specific regulation of the CYP4A genes.	CYP4A11 CYP4A22	2.28e-06	2	53	2	2766933
Pubmed	Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension.	CYP4A11 CYP4A22	2.28e-06	2	53	2	15611369
Pubmed	Further expanding the mutational spectrum and investigation of genotype-phenotype correlation in 3M syndrome.	OBSL1 CUL7	2.28e-06	2	53	2	30980518
Pubmed	20-HETE induces remodeling of renal resistance arteries independent of blood pressure elevation in hypertension.	CYP4A11 CYP4A22	2.28e-06	2	53	2	23825080
Pubmed	Natural history of facial and skeletal features from neonatal period to adulthood in a 3M syndrome cohort with biallelic CUL7 or OBSL1 variants.	OBSL1 CUL7	2.28e-06	2	53	2	34597859
Pubmed	Phc2 controls hematopoietic stem and progenitor cell mobilization from bone marrow by repressing Vcam1 expression.	VCAM1 PHC2	2.28e-06	2	53	2	31375680
Pubmed	Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel.	CYP4A11 CYP4A22	2.28e-06	2	53	2	16691295
Pubmed	Deduced amino acid sequence of a murine cytochrome P-450 Cyp4a protein: developmental and hormonal regulation in liver and kidney.	CYP4A11 CYP4A22	2.28e-06	2	53	2	8031839
Pubmed	The P450 gene superfamily: recommended nomenclature.	CYP4A11 CYP4A22	2.28e-06	2	53	2	3829886
Pubmed	Human fatty acid omega-hydroxylase, CYP4A11: determination of complete genomic sequence and characterization of purified recombinant protein.	CYP4A11 CYP4A22	2.28e-06	2	53	2	10860550
Pubmed	Identification and characterisation of novel mammalian homologues of Drosophila polyhomeoticpermits new insights into relationships between members of the polyhomeotic family.	PHC3 PHC2	2.28e-06	2	53	2	12384788
Pubmed	Induction of cytochrome P450 4A14 contributes to angiotensin II-induced renal fibrosis in mice.	CYP4A11 CYP4A22	2.28e-06	2	53	2	29277328
Pubmed	Mouse Cyp4a isoforms: enzymatic properties, gender- and strain-specific expression, and role in renal 20-hydroxyeicosatetraenoic acid formation.	CYP4A11 CYP4A22	2.28e-06	2	53	2	17112342
Pubmed	Genetic polymorphism of CYP4A11 and CYP4A22 genes and in silico insights from comparative 3D modelling in a French population.	CYP4A11 CYP4A22	2.28e-06	2	53	2	21820496
Pubmed	Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension.	CYP4A11 CYP4A22	2.28e-06	2	53	2	11320253
Pubmed	Androgen-sensitive hypertension associates with upregulated vascular CYP4A12-20-HETE synthase.	CYP4A11 CYP4A22	2.28e-06	2	53	2	23641057
Pubmed	Characterization of the CYP4A11 gene, a second CYP4A gene in humans.	CYP4A11 CYP4A22	2.28e-06	2	53	2	12464262
Pubmed	Renal function and vasomotor activity in mice lacking the Cyp4a14 gene.	CYP4A11 CYP4A22	2.28e-06	2	53	2	20943934
Pubmed	The Blood Pressure-Lowering Effect of 20-HETE Blockade in Cyp4a14(-/-) Mice Is Associated with Natriuresis.	CYP4A11 CYP4A22	2.28e-06	2	53	2	28912346
Pubmed	High-fat diet-induced obesity and insulin resistance in CYP4a14-/- mice is mediated by 20-HETE.	CYP4A11 CYP4A22	2.28e-06	2	53	2	30088983
Pubmed	Expression of cytochrome P450 4A mRNA in mouse lung: effect of clofibrate and interleukin-1beta.	CYP4A11 CYP4A22	2.28e-06	2	53	2	15066132
Pubmed	Altered inflammatory responses to Citrobacter rodentium infection, but not bacterial lipopolysaccharide, in mice lacking the Cyp4a10 or Cyp4a14 genes.	CYP4A11 CYP4A22	2.28e-06	2	53	2	24413902
Pubmed	Mechanisms of podocyte injury in diabetes: role of cytochrome P450 and NADPH oxidases.	CYP4A11 CYP4A22	2.28e-06	2	53	2	19208908
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	AKAP6 NAA25 OBSL1 CHD9 CHD6 PLEC ZFC3H1 LRRFIP1 EXOC4 AGAP3 CEP63	3.07e-06	1285	53	11	35914814
Pubmed	Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis.	CYP4A11 CYP4A22	6.83e-06	3	53	2	28270609
Pubmed	The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature.	CYP4A11 CYP4A22	6.83e-06	3	53	2	1991046
Pubmed	Genetic analysis of resistance to radiation lymphomagenesis with recombinant inbred strains of mice.	CYP4A11 CYP4A22	6.83e-06	3	53	2	2354437
Pubmed	Three M Syndrome	OBSL1 CUL7	6.83e-06	3	53	2	20301654
Pubmed	Exome sequencing identifies CCDC8 mutations in 3-M syndrome, suggesting that CCDC8 contributes in a pathway with CUL7 and OBSL1 to control human growth.	OBSL1 CUL7	6.83e-06	3	53	2	21737058
Pubmed	Increased renal proximal convoluted tubule transport contributes to hypertension in Cyp4a14 knockout mice.	CYP4A11 CYP4A22	6.83e-06	3	53	2	19713718
Pubmed	Mouse cathepsin D gene: molecular organization, characterization of the promoter, and chromosomal localization.	CYP4A11 CYP4A22	6.83e-06	3	53	2	8011168
Pubmed	Peroxisome proliferator activated receptor alpha regulates a male-specific cytochrome P450 in mouse liver.	CYP4A11 CYP4A22	6.83e-06	3	53	2	15313227
Pubmed	Mutations in CUL7, OBSL1 and CCDC8 in 3-M syndrome lead to disordered growth factor signalling.	OBSL1 CUL7	6.83e-06	3	53	2	23018678
Pubmed	H19/Mir-130b-3p/Cyp4a14 potentiate the effect of praziquantel on liver in the treatment of Schistosoma japonicum infection.	CYP4A11 CYP4A22	6.83e-06	3	53	2	37659685
Pubmed	A rare cause of syndromic short stature: 3M syndrome in three families.	OBSL1 CUL7	6.83e-06	3	53	2	33258289
Pubmed	The genetics of 3-M syndrome: unravelling a potential new regulatory growth pathway.	OBSL1 CUL7	6.83e-06	3	53	2	22156540
Pubmed	A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a and Cyp4b, but not of CYP4F, genes in mouse and humans.	CYP4A11 CYP4A22	6.83e-06	3	53	2	9271096
Pubmed	Murine c-mpl: a member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal.	CYP4A11 CYP4A22	1.36e-05	4	53	2	8334987
Pubmed	The 3M complex maintains microtubule and genome integrity.	OBSL1 CUL7	1.36e-05	4	53	2	24793695
Pubmed	Mapping of the azh locus to mouse chromosome 4.	CYP4A11 CYP4A22	1.36e-05	4	53	2	1552159
Pubmed	Differences in metabolite burden of di(2-ethylhexyl)phthalate in pregnant and postpartum dams and their offspring in relation to drug-metabolizing enzymes in mice.	CYP4A11 CYP4A22	1.36e-05	4	53	2	22159897
Pubmed	Altered expression of hepatic CYP2E1 and CYP4A in obese, diabetic ob/ob mice, and fa/fa Zucker rats.	CYP4A11 CYP4A22	1.36e-05	4	53	2	10049703
Pubmed	Salt modulates vascular response through adenosine A(2A) receptor in eNOS-null mice: role of CYP450 epoxygenase and soluble epoxide hydrolase.	CYP4A11 CYP4A22	1.36e-05	4	53	2	21161333
Pubmed	Species-specific induction of cytochrome P-450 4A RNAs: PCR cloning of partial guinea-pig, human and mouse CYP4A cDNAs.	CYP4A11 CYP4A22	2.27e-05	5	53	2	8363569
Pubmed	Modulation by salt intake of the vascular response mediated through adenosine A(2A) receptor: role of CYP epoxygenase and soluble epoxide hydrolase.	CYP4A11 CYP4A22	2.27e-05	5	53	2	20427718
Pubmed	Mapping of guanylin to murine chromosome 4 and human chromosome 1p34-p35.	CYP4A11 CYP4A22	2.27e-05	5	53	2	7601480
Pubmed	Genesis, a winged helix transcriptional repressor with expression restricted to embryonic stem cells.	CYP4A11 CYP4A22	3.40e-05	6	53	2	8798505
Pubmed	Organization of the distal end of mouse chromosome 4.	CYP4A11 CYP4A22	3.40e-05	6	53	2	3166417
Pubmed	Peroxisome proliferator-activated receptor-α accelerates α-chlorofatty acid catabolism.	CYP4A11 CYP4A22	3.40e-05	6	53	2	28007964
Pubmed	Mouse uroporphyrinogen decarboxylase: cDNA cloning, expression, and mapping.	CYP4A11 CYP4A22	3.40e-05	6	53	2	8661721
Pubmed	Peroxisome proliferator-activated receptor alpha-responsive genes induced in the newborn but not prenatal liver of peroxisomal fatty acyl-CoA oxidase null mice.	CYP4A11 CYP4A22	3.40e-05	6	53	2	11461119
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	PHC3 NELFCD CHD6 PLEC DENND4C EXOC4	4.14e-05	418	53	6	34709266
Pubmed	Activation of PPAR-alpha in streptozotocin-induced diabetes is essential for resistance against acetaminophen toxicity.	CYP4A11 CYP4A22	4.76e-05	7	53	2	12958197
Pubmed	Perfluorocarboxylic acids induce cytochrome P450 enzymes in mouse liver through activation of PPAR-alpha and CAR transcription factors.	CYP4A11 CYP4A22	4.76e-05	7	53	2	18648086
Pubmed	Molecular mapping of the mouse db mutation.	CYP4A11 CYP4A22	4.76e-05	7	53	2	1978328
Pubmed	Microdissection and microcloning of mid-chromosome 4: genetic mapping of 41 microdissection clones.	CYP4A11 CYP4A22	6.34e-05	8	53	2	8098006
Pubmed	Drug metabolizing enzyme induction pathways in experimental non-alcoholic steatohepatitis.	CYP4A11 CYP4A22	6.34e-05	8	53	2	18488193
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	PHC3 CHD9 CHD6 CUL7 PHC2	7.06e-05	282	53	5	23667531
Pubmed	Mammalian Polycomb complexes are required for Peyer's patch development by regulating lymphoid cell proliferation.	VCAM1 PHC2	8.15e-05	9	53	2	16815646
Pubmed	The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature.	CYP4A11 CYP4A22	8.15e-05	9	53	2	7678494
Pubmed	Mapping genes encoding drug-metabolizing enzymes in recombinant inbred mice.	CYP4A11 CYP4A22	8.15e-05	9	53	2	1685137
Pubmed	Filament-associated TSGA10 protein is expressed in professional antigen presenting cells and interacts with vimentin.	OBSL1 PLEC	1.02e-04	10	53	2	20797700
Pubmed	Genetic mapping of meander tail, a mouse mutation affecting cerebellar development.	CYP4A11 CYP4A22	1.02e-04	10	53	2	2037292
Pubmed	Card9 protects fungal peritonitis through regulating Malt1-mediated activation of autophagy in macrophage.	MALT1 PLEC	1.49e-04	12	53	2	35850054
Pubmed	Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus.	PHC3 PHC2	1.49e-04	12	53	2	19636380
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	SPATA7 OBSL1 ANKMY2 UXT PLEC SPAG16 DENND4C EXOC4 AGAP3	1.57e-04	1321	53	9	27173435
Pubmed	Slc25a17 Gene Trapped Mice: PMP34 Plays a Role in the Peroxisomal Degradation of Phytanic and Pristanic Acid.	CYP4A11 CYP4A22	1.76e-04	13	53	2	32266253
Pubmed	Mechanical regulation of glycolysis via cytoskeleton architecture.	VWA8 PLEC	2.05e-04	14	53	2	32051585
Pubmed	Establishment and analysis of a mouse model that regulates sex-related differences in liver drug metabolism.	CYP4A11 CYP4A22	2.36e-04	15	53	2	29968852
Pubmed	The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans.	PHC3 PHC2	2.70e-04	16	53	2	12167701
Pubmed	Exon structure of the nuclear factor I DNA-binding domain from C. elegans to mammals.	CYP4A11 CYP4A22	2.70e-04	16	53	2	10087299
Pubmed	Effects of perfluorooctanoic acid (PFOA) on expression of peroxisome proliferator-activated receptors (PPAR) and nuclear receptor-regulated genes in fetal and postnatal CD-1 mouse tissues.	CYP4A11 CYP4A22	2.70e-04	16	53	2	22154759
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	CLCN3 NELFCD SANBR ZBTB41 CHD6 VPS36 ULK1 PLEC ZFC3H1	3.01e-04	1442	53	9	35575683
Pubmed	RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly.	ULK1 EXOC4	3.05e-04	17	53	2	21241894
Pubmed	An OBSL1-Cul7Fbxw8 ubiquitin ligase signaling mechanism regulates Golgi morphology and dendrite patterning.	OBSL1 CUL7	3.05e-04	17	53	2	21572988
Pubmed	Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic Cyp Gene Expression in the Adult Mouse Liver.	CYP4A11 CYP4A22	3.05e-04	17	53	2	27197076
Pubmed	HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis.	OBSL1 CUL7 EXOC4	3.24e-04	87	53	3	33711283
Pubmed	CRL7SMU1 E3 ligase complex-driven H2B ubiquitylation functions in sister chromatid cohesion by regulating SMC1 expression.	OBSL1 CUL7	3.43e-04	18	53	2	29507117
Pubmed	Expression of murine cyclin B1 mRNAs and genetic mapping of related genomic sequences.	CYP4A11 CYP4A22	3.43e-04	18	53	2	1387105
Pubmed	A conserved acetylation switch enables pharmacological control of tubby-like protein stability.	OBSL1 CHD9 CUL7 LRRFIP1	3.77e-04	223	53	4	33187986
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ARFGEF3 OBSL1 CHD6 ULK1 MAP3K4	3.87e-04	407	53	5	12693553
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	AKAP6 RTEL1 OBSL1 CHD6	3.90e-04	225	53	4	12168954
Pubmed	The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets.	SPATA7 CLCN3 OBSL1 AGAP3	3.90e-04	225	53	4	25277244
Pubmed	SENP3 and USP7 regulate Polycomb-rixosome interactions and silencing functions.	PHC3 PHC2	4.70e-04	21	53	2	37014752
Pubmed	PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos.	PHC3 PHC2	4.70e-04	21	53	2	18311137
Pubmed	Intracisternal A-type particle elements as genetic markers: detection by repeat element viral element amplified locus-PCR.	CYP4A11 CYP4A22	6.16e-04	24	53	2	7873878
Pubmed	TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation.	OBSL1 CHD9 CHD6	6.26e-04	109	53	3	33554859
Pubmed	Molecular genetic linkage maps of mouse chromosomes 4 and 6.	CYP4A11 CYP4A22	7.23e-04	26	53	2	1684952
Pubmed	Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia.	CYP4A11 CYP4A22	7.80e-04	27	53	2	28167773
Pubmed	HENA, heterogeneous network-based data set for Alzheimer's disease.	ZFC3H1 EXOC4 CEP63	8.27e-04	120	53	3	31413325
Pubmed	Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8.	OBSL1 CUL7	8.40e-04	28	53	2	25752541
Pubmed	Profiling, Bioinformatic, and Functional Data on the Developing Olfactory/GnRH System Reveal Cellular and Molecular Pathways Essential for This Process and Potentially Relevant for the Kallmann Syndrome.	AKAP6 HIPK2	8.40e-04	28	53	2	24427155
Pubmed	AMPK Interactome Reveals New Function in Non-homologous End Joining DNA Repair.	KCNT2 ULK1 PARS2	8.48e-04	121	53	3	31900314
Pubmed	A human MAP kinase interactome.	CEP250 HIPK2 CHD6 PLEC MAP3K4	8.62e-04	486	53	5	20936779
Pubmed	The phosphorylation status of T522 modulates tissue-specific functions of SIRT1 in energy metabolism in mice.	CYP4A11 CYP4A22	9.01e-04	29	53	2	28364022
Pubmed	Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers.	PHC3 CHD6 PHC2	9.10e-04	124	53	3	20850016
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	TIMELESS DENND4C LRRFIP1 EXOC4 AGAP3	1.01e-03	503	53	5	16964243
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	VWA8 INTS4 CHD9 CHD6 PLEC PARS2 PHC2	1.22e-03	1082	53	7	38697112
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	AKAP6 PHC3 HIPK2 ZBTB41 TIMELESS PLEC CEP63	1.24e-03	1084	53	7	11544199
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	PHC3 NAA25 NELFCD CHD9 PHC2	1.30e-03	533	53	5	30554943
Interaction	H4C8 interactions	CEP250 OBSL1 CUL7 VCAM1	4.02e-06	41	53	4	int:H4C8
Interaction	CYP4A22 interactions	CYP4A11 CYP4A22	2.03e-05	3	53	2	int:CYP4A22
Interaction	HBA1 interactions	CEP250 OBSL1 CUL7 VCAM1	2.89e-05	67	53	4	int:HBA1
Cytoband	1q31.3	KCNT2 ZBTB41	1.55e-04	16	53	2	1q31.3
Cytoband	1p33	CYP4A11 CYP4A22	7.59e-04	35	53	2	1p33
Cytoband	Ensembl 112 genes in cytogenetic band chr9p22	BNC2 DENND4C	1.74e-03	53	53	2	chr9p22
Cytoband	Ensembl 112 genes in cytogenetic band chr1p33	CYP4A11 CYP4A22	2.29e-03	61	53	2	chr1p33
ToppCell	droplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BNC2 KCNT2 FAM167A PKDCC CUL7	2.38e-06	180	53	5	c4068fe47408cfd899131a85fa4b7e5908926f94
Disease	3-M syndrome (is_implicated_in)	OBSL1 CUL7	9.13e-06	3	52	2	DOID:0060241 (is_implicated_in)
Disease	3-M syndrome	OBSL1 CUL7	9.13e-06	3	52	2	cv:C1848862
Disease	X-14939 measurement	CYP4A11 CYP4A22	4.55e-05	6	52	2	EFO_0800747
Disease	CHARGE syndrome (implicated_via_orthology)	CHD9 CHD6	6.36e-05	7	52	2	DOID:0050834 (implicated_via_orthology)
Disease	ocular hypertension, response to triamcinolone acetonide	VWA8 CHD9 TIMELESS	8.98e-05	49	52	3	EFO_0006954, EFO_1001069
Disease	autosomal recessive polycystic kidney disease (biomarker_via_orthology)	CYP4A11 CYP4A22	1.66e-04	11	52	2	DOID:0110861 (biomarker_via_orthology)
Disease	hemopexin measurement	KCNT2 ZBTB41	1.66e-04	11	52	2	EFO_0008149
Disease	central nervous system cancer, glioma	AKAP6 RTEL1	1.20e-03	29	52	2	EFO_0000326, EFO_0005543
Disease	complement factor H-related protein 2 measurement	KCNT2 ZBTB41	1.20e-03	29	52	2	EFO_0600055
Disease	cesarean section, Self-injurious behavior	LRRFIP1 EXOC4	1.46e-03	32	52	2	EFO_0009636, HP_0100716
Disease	word list delayed recall measurement, memory performance	CHD6 ADA2	1.55e-03	33	52	2	EFO_0004874, EFO_0006805
Disease	Microlissencephaly	KATNB1 CEP63	1.55e-03	33	52	2	C1956147
Disease	blood molybdenum measurement	AKAP6 NAA25	2.06e-03	38	52	2	EFO_0007582
Disease	Combined immunodeficiency	MALT1 ADA2	2.39e-03	41	52	2	C0494261

Protein segments in the cluster

Peptide	Gene	Start	Entry
DLRLLVMLLAHGSKE	AGAP3	761	Q96P47
HMKTLLLLQDTERLK	ERICH1	391	Q86X53
VLLRLHKAGARVKIM	APOBEC3D	146	Q96AK3
NLHRKLLTKELDDMG	BNC2	886	Q6ZN30
KRHLDFLDILLLAKM	CYP4A11	286	Q02928
LKRHKLGMLTIGEDL	IQCH	946	Q86VS3
IKAMLQLHERGLKLH	INTS4	216	Q96HW7
LLVVKMDGRKHRLIL	OBSL1	761	O75147
ALMKLKSLGLIHADL	HIPK2	311	Q9H2X6
ELKKTLLDRMVHLLS	NELFCD	491	Q8IXH7
LIAKLDMHRGLGRKT	MALT1	711	Q9UDY8
DLEAAKILRTLMGHK	KATNB1	91	Q9BVA0
KPHLLVLNKMDLADL	MTG1	76	Q9BT17
KHLGKLELAQELRDM	CUL7	761	Q14999
ELAELVKNRMKHLGL	KCNT2	1051	Q6UVM3
IDGQALLLLKEDHLM	PHC3	946	Q8NDX5
QHLGLALDLDRMKKD	NBPF3	451	Q9H094
DLRLELHSKKMNLHL	EXOC4	176	Q96A65
EGLKLMNLEHKVLLT	CHD9	1011	Q3L8U1
LEGLKLMALEHKVLL	CHD6	611	Q8TD26
MKLELGLHEAKEISL	CEP63	481	Q96MT8
KRKSHLDLLKLIMDG	ARFGEF3	396	Q5TH69
KRHLDFLDILLLAKM	CYP4A22	286	Q5TCH4
LLDLIKGMKYLHHRE	GUCY2F	651	P51841
RGSLEHMKLILRDKE	CEP250	1721	Q9BV73
RELLSEKQLMHLGLL	DENND4C	281	Q5VZ89
HLLLKEKMMRLGGRL	ADA2	36	Q9NZK5
KGKLDMCKLLLRHGA	ANKMY2	56	Q8IV38
HMLLVDLELLLGIAK	MAN2C1	186	Q9NTJ4
LDKETHLGNEMLRLK	CCDC168	5316	Q8NDH2
LKQREEMLEKHGIIL	LRRFIP1	241	Q32MZ4
LMRLRGDINKLKIEH	FAM167A	141	Q96KS9
KLILRLHKLMDGSLQ	MAP3K4	541	Q9Y6R4
AKLKMILLRLEGAID	RTEL1	316	Q9NZ71
LMGKELLRLRDRHGK	PARS2	136	Q7L3T8
DRLEIDLLKGDHLMK	VCAM1	146	P19320
LAAHKLLKEMVLLER	PKDCC	191	Q504Y2
GHLIKMRLGDLDRVK	SANBR	656	Q6NSI8
LLELIASHKAGLKDM	AKAP6	846	Q13023
LLGIITKKDILRHMA	CLCN3	791	P51790
RLMGSVKDHLLREKA	TIMELESS	356	Q9UNS1
IDGQALLLLKEDHLM	PHC2	821	Q8IXK0
LLAKERLLLAEKMGH	VPS36	351	Q86VN1
IKAHIHMLLEGLREL	UXT	131	Q9UBK9
RSLLLGKKHGLKMLE	ZBTB41	231	Q5SVQ8
IHLLDLKSGEIHKLM	SPAG16	586	Q8N0X2
EKMRHLLHVLKVDLG	SPATA7	406	Q9P0W8
MKKGLILKDHGIRLL	PLEC	4166	Q15149
DMLKDFLLGEHLLLV	VWA8	766	A3KMH1
HRILLMKDESVLKNL	ZFC3H1	836	O60293
MRLLHSKGIIHRDLK	ULK1	126	O75385
KLEKMRILAHGELVL	TLE6	276	Q9H808
HSLLEMGELLKKRLE	NAA25	951	Q14CX7