Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionG protein-coupled receptor kinase activity

GRK4 GRK5 GRK6

3.83e-067973GO:0004703
GeneOntologyMolecularFunctionATP-dependent activity

DNHD1 MYD88 ATP13A4 MYH9 ABCA4 CHD1 ABCA8 MSH6 MDN1 ATP11C ABCC2 ASCC3

4.22e-056149712GO:0140657
GeneOntologyMolecularFunctionhistone modifying activity

JAK2 MED24 KMT2C BRPF1 KDM2B KDM2A ATM

1.27e-04229977GO:0140993
GeneOntologyMolecularFunctionbeta-adrenergic receptor kinase activity

GRK5 GRK6

1.39e-044972GO:0047696
GeneOntologyMolecularFunctionhistone H3K36me/H3K36me2 demethylase activity

KDM2B KDM2A

1.39e-044972GO:0140680
GeneOntologyMolecularFunctionphosphatidylethanolamine flippase activity

ABCA4 ATP11C

4.83e-047972GO:0090555
GeneOntologyBiologicalProcessmembrane lipid biosynthetic process

HACD3 GAL3ST1 SMPD4 ABCA8 ELOVL7 CERS5 ST3GAL5 MPPE1

8.30e-07157988GO:0046467
GeneOntologyBiologicalProcesssphingolipid biosynthetic process

HACD3 GAL3ST1 SMPD4 ABCA8 ELOVL7 CERS5 ST3GAL5

1.42e-06117987GO:0030148
GeneOntologyBiologicalProcessmembrane lipid metabolic process

HACD3 GAL3ST1 SMPD4 ABCA8 ELOVL7 CERS5 ST3GAL5 MPPE1

1.36e-05229988GO:0006643
GeneOntologyBiologicalProcessamide biosynthetic process

GAL3ST1 SMPD4 SLC1A1 ABCA8 ELOVL7 CERS5 ST3GAL5

1.81e-05172987GO:0043604
GeneOntologyBiologicalProcesssphingolipid metabolic process

HACD3 GAL3ST1 SMPD4 ABCA8 ELOVL7 CERS5 ST3GAL5

2.10e-05176987GO:0006665
GeneOntologyBiologicalProcesslipid biosynthetic process

HACD3 GAL3ST1 AMACR SMPD4 CYP39A1 LDLR ABCA8 ELOVL7 CERS5 MECR ST3GAL5 PIK3CD ATM MPPE1

2.95e-058139814GO:0008610
GeneOntologyCellularComponentextrinsic component of membrane

MYD88 CYTH1 JAK2 ARHGEF40 CADPS PIK3CD ATM GNAS

1.48e-052301008GO:0019898
GeneOntologyCellularComponentcytoplasmic side of plasma membrane

MYD88 MYH9 CYTH1 SPTB KCNIP1 JAK2 GNAS

3.04e-051851007GO:0009898
GeneOntologyCellularComponentcytoplasmic side of membrane

MYD88 MYH9 CYTH1 SPTB KCNIP1 JAK2 GNAS

1.20e-042301007GO:0098562
GeneOntologyCellularComponentrecycling endosome membrane

PLEKHB2 ATP13A4 SLC1A1 LDLR ATP11C

2.03e-041121005GO:0055038
GeneOntologyCellularComponentrecycling endosome

PLEKHB2 ATP13A4 SLC1A1 LDLR ATP11C GNAS

6.97e-042221006GO:0055037
DomainGPCR_kinase

GRK4 GRK5 GRK6

5.13e-0671003IPR000239
DomainRGS

MYH9 GRK4 GRK5 GRK6

5.51e-05391004IPR016137
DomainRFX1_trans_act

RFX1 RFX3

8.48e-0531002IPR007668
DomainRFX1_trans_act

RFX1 RFX3

8.48e-0531002PF04589
DomainPHD_4

KDM2B KDM2A

8.48e-0531002PF16866
DomainNeurofascin/L1/NrCAM_C

CHL1 NFASC

1.69e-0441002IPR026966
DomainBravo_FIGEY

CHL1 NFASC

1.69e-0441002PF13882
DomainFAT

TMTC1 ATM

4.20e-0461002PF02259
DomainPIK-rel_kinase_FAT

TMTC1 ATM

4.20e-0461002IPR003151
DomainZnf_PHD-finger

KMT2C BRPF1 KDM2B KDM2A

8.55e-04791004IPR019787
DomainRGS

GRK4 GRK5 GRK6

8.61e-04351003PF00615
DomainRGS

GRK4 GRK5 GRK6

8.61e-04351003SM00315
DomainRGS

GRK4 GRK5 GRK6

9.35e-04361003PS50132
DomainRFX_DNA_binding

RFX1 RFX3

9.97e-0491002PF02257
DomainDNA-bd_RFX

RFX1 RFX3

9.97e-0491002IPR003150
DomainRFX_DBD

RFX1 RFX3

9.97e-0491002PS51526
DomainAAA

ABCA4 ABCA8 MDN1 ABCC2 ASCC3

1.06e-031441005SM00382
DomainAAA+_ATPase

ABCA4 ABCA8 MDN1 ABCC2 ASCC3

1.06e-031441005IPR003593
DomainPHD

KMT2C BRPF1 KDM2B KDM2A

1.33e-03891004SM00249
DomainZnf_PHD

KMT2C BRPF1 KDM2B KDM2A

1.45e-03911004IPR001965
DomainZF_CXXC

KDM2B KDM2A

1.51e-03111002PS51058
DomainZnf_CXXC

KDM2B KDM2A

1.51e-03111002IPR002857
Domainzf-CXXC

KDM2B KDM2A

1.51e-03111002PF02008
DomainZF_PHD_2

KMT2C BRPF1 KDM2B KDM2A

1.70e-03951004PS50016
DomainZF_PHD_1

KMT2C BRPF1 KDM2B KDM2A

1.76e-03961004PS01359
DomainABC_A

ABCA4 ABCA8

1.81e-03121002IPR026082
DomainP-loop_NTPase

DNHD1 MYH9 ABCA4 GAL3ST1 CHD1 ABCA8 MSH6 SPATA17 MDN1 GNAS ABCC2 ASCC3

1.90e-0384810012IPR027417
DomainABC_tran

ABCA4 ABCA8 ABCC2

2.16e-03481003PF00005
DomainABC_TRANSPORTER_2

ABCA4 ABCA8 ABCC2

2.16e-03481003PS50893
DomainABC_TRANSPORTER_1

ABCA4 ABCA8 ABCC2

2.30e-03491003PS00211
DomainABC_transporter-like

ABCA4 ABCA8 ABCC2

2.43e-03501003IPR003439
DomainPI3/4_kinase_CS

PIK3CD ATM

2.85e-03151002IPR018936
DomainLY

LDLR ROS1

2.85e-03151002SM00135
DomainLDLR_classB_rpt

LDLR ROS1

2.85e-03151002IPR000033
Domain-

PIK3CD ATM

3.24e-031610021.10.1070.11
DomainPI3Kc

PIK3CD ATM

3.24e-03161002SM00146
DomainAT_hook

AHCTF1 KMT2C

3.24e-03161002PF02178
DomainAGC-kinase_C

GRK4 GRK5 GRK6

3.36e-03561003IPR000961
DomainAGC_KINASE_CTER

GRK4 GRK5 GRK6

3.36e-03561003PS51285
DomainS_TK_X

GRK4 GRK5 GRK6

3.36e-03561003SM00133
DomainPH

PLEKHB2 CYTH1 PLEKHA6 ARHGEF40 CADPS ARHGAP12

3.82e-032781006SM00233
DomainPH_DOMAIN

PLEKHB2 CYTH1 PLEKHA6 ARHGEF40 CADPS ARHGAP12

3.89e-032791006PS50003
DomainPH_domain

PLEKHB2 CYTH1 PLEKHA6 ARHGEF40 CADPS ARHGAP12

3.96e-032801006IPR001849
DomainPI3_PI4_kinase

PIK3CD ATM

4.11e-03181002PF00454
DomainPI3_4_KINASE_1

PIK3CD ATM

4.11e-03181002PS00915
DomainPI3_4_KINASE_2

PIK3CD ATM

4.11e-03181002PS00916
DomainPI3/4_kinase_cat_dom

PIK3CD ATM

4.11e-03181002IPR000403
DomainPI3_4_KINASE_3

PIK3CD ATM

4.11e-03181002PS50290
DomainLeu-rich_rpt_Cys-con_subtyp

KDM2B KDM2A

4.57e-03191002IPR006553
DomainLRR_CC

KDM2B KDM2A

4.57e-03191002SM00367
DomainPWWP

MSH6 BRPF1

5.06e-03201002SM00293
DomainCH

MICAL1 SPTB UTRN

5.12e-03651003SM00033
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

MYH9 HACD3 NFASC FOCAD JAK2 MSH6 KMT2C MDN1 AHR ATM ZBTB11 UTRN PLXNB3

2.27e-077361011329676528
Pubmed

The GRK4 subfamily of G protein-coupled receptor kinases. Alternative splicing, gene organization, and sequence conservation.

GRK4 GRK5 GRK6

4.72e-076101310506199
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

CYTH1 GRK5 GRK6 SFI1 GRIN2D MLXIP LDLR FOCAD JAK2 KMT2C ARHGEF40 MDN1 MEGF8 PIK3CD TTLL4

7.16e-0711051011535748872
Pubmed

Members of the G protein-coupled receptor kinase family that phosphorylate the beta2-adrenergic receptor facilitate sequestration.

GRK4 GRK5 GRK6

8.25e-07710138672451
Pubmed

Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function.

GRK4 GRK5 GRK6

8.25e-077101311517230
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

MYH9 AHCTF1 CHD1 RPL14 NSUN2 MSH6 MDN1 ATM ASCC3 ZBTB11 UTRN

3.24e-066531011122586326
Pubmed

Treg-mediated suppression of atherosclerosis requires MYD88 signaling in DCs.

MYD88 LDLR

8.35e-062101223257360
Pubmed

Glomerular-specific imprinting of the mouse gsalpha gene: how does this relate to hormone resistance in albright hereditary osteodystrophy?

GNAS UTRN

8.35e-06210128812454
Pubmed

Combined expression levels of KDM2A and KDM2B correlate with nucleolar size and prognosis in primary breast carcinomas.

KDM2B KDM2A

8.35e-062101232901907
Pubmed

Nonsynonymous variants in MYH9 and ABCA4 are the most frequent risk loci associated with nonsyndromic orofacial cleft in Taiwanese population.

MYH9 ABCA4

8.35e-062101227527345
Pubmed

Inhibitory effects of two G protein-coupled receptor kinases on the cell surface expression and signaling of the human adrenomedullin receptor.

GRK4 GRK5

8.35e-062101226820533
Pubmed

RFX1 and RFX3 Transcription Factors Interact with the D Sequence of Adeno-Associated Virus Inverted Terminal Repeat and Regulate AAV Transduction.

RFX1 RFX3

8.35e-062101229317724
Pubmed

Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection.

GRK5 GRK6

8.35e-062101217786238
Pubmed

Biological Functions of the KDM2 Family of Histone Demethylases.

KDM2B KDM2A

8.35e-062101237751135
Pubmed

Macrophage Inflammation, Erythrophagocytosis, and Accelerated Atherosclerosis in Jak2 V617F Mice.

LDLR JAK2

8.35e-062101230571460
Pubmed

Role for the regulator of G-protein signaling homology domain of G protein-coupled receptor kinases 5 and 6 in beta 2-adrenergic receptor and rhodopsin phosphorylation.

GRK5 GRK6

8.35e-062101220038610
Pubmed

KDM2 proteins constrain transcription from CpG island gene promoters independently of their histone demethylase activity.

KDM2B KDM2A

8.35e-062101231363749
Pubmed

The Aryl Hydrocarbon Receptor Regulates Invasiveness and Motility in Acute Myeloid Leukemia Cells through Expressional Regulation of Non-Muscle Myosin Heavy Chain IIA.

MYH9 AHR

8.35e-062101239125717
Pubmed

Atypical, milder presentation in a child with CC2D2A and KIDINS220 variants.

KIDINS220 CC2D2A

8.35e-062101231577543
Pubmed

Lack of glutamate transporter EAAC1 in the epididymis of infertile c-ros receptor tyrosine-kinase deficient mice.

SLC1A1 ROS1

8.35e-062101212399522
Pubmed

Functional screening of FxxLF-like peptide motifs identifies SMARCD1/BAF60a as an androgen receptor cofactor that modulates TMPRSS2 expression.

MED24 MDN1 MED12L

1.05e-0515101319762545
Pubmed

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.

GAL3ST1 SMPD4 TMEM87A LDLR ELOVL7 FOCAD JAK2 MED24 MDN1 AHR ATP11C ATM IPO11

1.26e-0510611011333845483
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

HACD3 RFX1 NSUN2 MED24 MSH6 TBC1D10B MDN1 BRPF1 KDM2B ATM EXOC2

1.60e-057741011115302935
Pubmed

Chromosomal mapping of the genes GPRK5 and GPRK6 encoding G protein-coupled receptor kinases GRK5 and GRK6.

GRK5 GRK6

2.50e-05310127789183
Pubmed

G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway.

GRK5 GRK6

2.50e-053101219801552
Pubmed

Involvement of RFX proteins in transcriptional activation from a Ras-responsive enhancer element.

RFX1 RFX3

2.50e-053101215024578
Pubmed

Role for RFX transcription factors in non-neuronal cell-specific inactivation of the microtubule-associated protein MAP1A promoter.

RFX1 RFX3

2.50e-053101212411430
Pubmed

RFX transcription factors are essential for hearing in mice.

RFX1 RFX3

2.50e-053101226469318
Pubmed

Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains.

RFX1 RFX3

2.50e-053101210330134
Pubmed

Ciliogenic RFX transcription factors regulate FGF1 gene promoter.

RFX1 RFX3

2.50e-053101222415835
Pubmed

A Structure-Based Strategy for Engineering Selective Ubiquitin Variant Inhibitors of Skp1-Cul1-F-Box Ubiquitin Ligases.

KDM2B KDM2A

2.50e-053101230033217
Pubmed

G protein-coupled receptor kinase GRK4. Molecular analysis of the four isoforms and ultrastructural localization in spermatozoa and germinal cells.

GRK4 GRK5

2.50e-05310129092566
Pubmed

Drosophila regulatory factor X is necessary for ciliated sensory neuron differentiation.

RFX1 RFX3

2.50e-053101212403718
Pubmed

GRK5 Gln41Leu polymorphism is not associated with sensitivity to beta(1)-adrenergic blockade in humans.

GRK4 GRK5

2.50e-053101219842931
Pubmed

Interplay of RFX transcription factors 1, 2 and 3 in motile ciliogenesis.

RFX1 RFX3

2.50e-053101232725242
Pubmed

Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN).

GRK5 GRK6

2.50e-053101218662895
Pubmed

Hepatic JAK2 protects against atherosclerosis through circulating IGF-1.

LDLR JAK2

2.50e-053101228724798
Pubmed

Dysregulation of schizophrenia-related aquaporin 3 through disruption of paranode influences neuronal viability.

GAL3ST1 NFASC

2.50e-053101230025158
Pubmed

Kdm2a/b Lysine Demethylases Regulate Canonical Wnt Signaling by Modulating the Stability of Nuclear β-Catenin.

KDM2B KDM2A

2.50e-053101226004508
Pubmed

Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice.

GRK5 GRK6

2.50e-053101212032308
Pubmed

Dyslipidemia induces opposing effects on intrapulmonary and extrapulmonary host defense through divergent TLR response phenotypes.

MYD88 LDLR

2.50e-053101220581153
Pubmed

Aryl hydrocarbon receptor mediates Jak2/STAT3 signaling for non-small cell lung cancer stem cell maintenance.

JAK2 AHR

2.50e-053101232941808
Pubmed

Expression of G-protein-coupled receptor kinases in pregnant term and non-pregnant human myometrium.

GRK5 GRK6

2.50e-053101210467231
Pubmed

RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins.

RFX1 RFX3

2.50e-05310128289803
Pubmed

Cigarette smoke extract stimulates PCSK9 production in HepG2 cells via ROS/NF‑κB signaling.

LDLR ROS1

2.50e-053101233760160
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

MLXIP EPG5 FOCAD KIDINS220 MEGF8 CADPS SV2B PLXNB3

2.57e-05407101812693553
Pubmed

Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.

KMT2C KDM2B KDM2A

3.04e-0521101327626377
Pubmed

Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.

CHL1 DNHD1 HACD3 SLC1A1 KMT2C KIDINS220

3.36e-05208101633230847
Pubmed

Genetic mutations associated with cigarette smoking in pancreatic cancer.

JAK2 MSH6 ATM GNAS

3.50e-0563101419351817
Pubmed

Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members.

RFX1 RFX3

4.99e-054101211682486
Pubmed

G-protein receptor kinases 2, 5 and 6 redundantly modulate Smoothened-GATA transcriptional crosstalk in fetal mouse hearts.

GRK5 GRK6

4.99e-054101229969579
Pubmed

MyD88 deficiency attenuates angiotensin II-induced abdominal aortic aneurysm formation independent of signaling through Toll-like receptors 2 and 4.

MYD88 LDLR

4.99e-054101221960563
Pubmed

Differential expression of Rfx1-4 during mouse spermatogenesis.

RFX1 RFX3

4.99e-054101219596083
Pubmed

Proximal Lck Promoter-Driven Cre Function Is Limited in Neonatal and Ineffective in Adult γδ T Cell Development.

KIDINS220 AHR

4.99e-054101231167772
Pubmed

Proatherogenic conditions promote autoimmune T helper 17 cell responses in vivo.

MYD88 LDLR

4.99e-054101224412615
Pubmed

B cell responses to apoptotic cells in MFG-E8-/- mice.

MYD88 LDLR

4.99e-054101230286201
Pubmed

Role of G protein-coupled receptor kinases on the agonist-induced phosphorylation and internalization of the follitropin receptor.

GRK4 GRK6

4.99e-054101210379886
Pubmed

In vivo ablation of NF-κB cascade effectors alleviates disease burden in myeloproliferative neoplasms.

MYD88 JAK2

4.99e-054101238457657
Pubmed

Heterozygous mutation of ataxia-telangiectasia mutated gene aggravates hypercholesterolemia in apoE-deficient mice.

LDLR ATM

4.99e-054101215863839
Pubmed

The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock.

MYD88 PIK3CD

4.99e-054101223023391
Pubmed

Reduced expression of G protein-coupled receptor kinases in schizophrenia but not in schizoaffective disorder.

GRK5 GRK6

4.99e-054101221784156
Pubmed

Correlation of dysfunction of nonmuscle myosin IIA with increased induction of Cyp1a1 in Hepa-1 cells.

MYH9 AHR

4.99e-054101221216307
Pubmed

L41Q polymorphism of the G protein coupled receptor kinase 5 is associated with left ventricular apical ballooning syndrome.

GRK5 GNAS

4.99e-054101220023040
Pubmed

Phosphorylation and desensitization of the human thromboxane receptor-alpha by G protein-coupled receptor kinases.

GRK5 GRK6

4.99e-054101211504827
Pubmed

Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22.

MYD88 AHR

4.99e-054101223973224
Pubmed

Histone demethylation by a family of JmjC domain-containing proteins.

KDM2B KDM2A

4.99e-054101216362057
Pubmed

Structural and functional evolution of the L1 family: are four adhesion molecules better than one?

CHL1 NFASC

4.99e-054101210662501
Pubmed

Vimentin and Non-Muscle Myosin IIA are Members of the Neural Precursor Cell Expressed Developmentally Down-Regulated 9 (NEDD9) Interactome in Head and Neck Squamous Cell Carcinoma Cells.

MICAL1 MYH9

4.99e-054101230267961
Pubmed

Innate response activator B cells aggravate atherosclerosis by stimulating T helper-1 adaptive immunity.

MYD88 LDLR

8.30e-055101224488984
Pubmed

Inflammatory stimuli induce acyl-CoA thioesterase 7 and remodeling of phospholipids containing unsaturated long (≥C20)-acyl chains in macrophages.

MYD88 LDLR

8.30e-055101228416579
Pubmed

Aberrantly expressed recoverin is functionally associated with G-protein-coupled receptor kinases in cancer cell lines.

GRK5 GRK6

8.30e-055101212507501
Pubmed

Glycosphingolipids are not pivotal receptors for Subtilase cytotoxin in vivo: sensitivity analysis with glycosylation-defective mutant mice.

GAL3ST1 ST3GAL5

8.30e-055101218996356
Pubmed

ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome.

LDLR ATM

8.30e-055101217084711
Pubmed

Evolutionarily dynamic alternative splicing of GPR56 regulates regional cerebral cortical patterning.

RFX1 RFX3

8.30e-055101224531968
Pubmed

c-Src, Insulin-Like Growth Factor I Receptor, G-Protein-Coupled Receptor Kinases and Focal Adhesion Kinase are Enriched Into Prostate Cancer Cell Exosomes.

GRK5 GRK6

8.30e-055101227232975
Pubmed

RFX proteins, a novel family of DNA binding proteins conserved in the eukaryotic kingdom.

RFX1 RFX3

8.30e-05510128600444
Pubmed

Genetic variations and treatments that affect the lifespan of the NPC1 mouse.

LDLR ST3GAL5

8.30e-055101218077828
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

PLEKHB2 HACD3 AHCTF1 NSUN2 CERS5 MED24 TBC1D10B ARHGEF40 KIDINS220 ASCC3 IPO11

9.39e-059421011131073040
Pubmed

PTEN identified as important risk factor of chronic obstructive pulmonary disease.

AMACR LDLR MSH6 AHR ROS1 ATM ABCC2

1.14e-04374101719625176
Pubmed

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.

MYH9 HACD3 RPL14 NSUN2 EPG5 MSH6 MDN1 BRPF1 GNAS UTRN

1.23e-048071011030575818
Pubmed

Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8.

ABCA4 ABCA8

1.24e-046101212111378
Pubmed

beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein.

GRK5 GRK6

1.24e-04610129826657
Pubmed

Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity.

GRK5 GRK6

1.24e-04610129211925
Pubmed

CD300a and CD300f differentially regulate the MyD88 and TRIF-mediated TLR signalling pathways through activation of SHP-1 and/or SHP-2 in human monocytic cell lines.

MYD88 CD300A

1.24e-046101222043923
Pubmed

A CD36-dependent pathway enhances macrophage and adipose tissue inflammation and impairs insulin signalling.

MYD88 LDLR

1.24e-046101221088116
Pubmed

Hyperglycemia promotes myelopoiesis and impairs the resolution of atherosclerosis.

MYD88 LDLR

1.24e-046101223663738
Pubmed

beta-Arrestin-biased agonism of the angiotensin receptor induced by mechanical stress.

GRK5 GRK6

1.24e-046101220530803
Pubmed

Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes.

GRK5 GRK6

1.24e-046101217060617
Pubmed

Elastin-derived peptides potentiate atherosclerosis through the immune Neu1-PI3Kγ pathway.

LDLR PIK3CD

1.24e-046101224357053
Pubmed

Association of polymorphisms of ABCA1 and ROS1 with hypertension in Japanese individuals.

LDLR ROS1

1.24e-046101218097620
Pubmed

The AHR repressor limits expression of antimicrobial genes but not AHR-dependent genes in intestinal eosinophils.

MYD88 AHR

1.24e-046101238701199
Pubmed

β-arrestin-biased agonism of β-adrenergic receptor regulates Dicer-mediated microRNA maturation to promote cardioprotective signaling.

GRK5 GRK6

1.24e-046101229627294
Pubmed

ATM-mediated KDM2A phosphorylation is required for the DNA damage repair.

KDM2A ATM

1.24e-046101225823024
Pubmed

Genome-wide association study of multiplex schizophrenia pedigrees.

TMTC1 EXOC2

1.24e-046101222885689
Pubmed

Chemokine regulation of atherosclerosis.

MYD88 LDLR

1.24e-046101217329566
Pubmed

Combinatorial depletions of G-protein coupled receptor kinases in immune cells identify pleiotropic and cell type-specific functions.

GRK5 GRK6

1.24e-046101236451830
Pubmed

Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.

AMACR LDLR MSH6 AHR ROS1 ATM ABCC2

1.27e-04381101718676680
Pubmed

Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.

AMACR LDLR MSH6 AHR ROS1 ATM ABCC2

1.30e-04382101719170196
Pubmed

HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP.

MYH9 TMEM87A UTRN

1.33e-0434101325925205
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

MYH9 HACD3 AHCTF1 CHD1 RPL14 NSUN2 MSH6 ARHGEF40 MDN1 KDM2A EXOC2 ASCC3 UTRN

1.50e-0413531011329467282
InteractionEDNRB interactions

MMS22L GRK6 ATM EXOC2 IPO11

1.37e-06391005int:EDNRB
InteractionGPR182 interactions

MMS22L AHCTF1 SMPD4 TMEM87A FOCAD CERS5 KIDINS220 MDN1 SURF1 ATM EXOC2 IPO11

2.64e-0645510012int:GPR182
InteractionSCN2B interactions

FOCAD MDN1 ATP11C ATM EXOC2 IPO11

7.81e-06951006int:SCN2B
Cytoband9p24

SLC1A1 JAK2

1.33e-04810129p24
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

PLEKHB2 CYTH1 SPTB PLEKHA6 CADPS ARHGAP12

1.34e-04206696682
GeneFamilyPHD finger proteins

KMT2C BRPF1 KDM2B KDM2A

3.88e-049069488
GeneFamilyRegulatory factor X family

RFX1 RFX3

3.96e-0486921153
GeneFamilyZinc fingers CXXC-type

KDM2B KDM2A

9.24e-0412692136
GeneFamilyATP binding cassette subfamily A

ABCA4 ABCA8

1.27e-0314692805
GeneFamilyF-box and leucine rich repeat proteins

KDM2B KDM2A

2.88e-0321692558
GeneFamilyPWWP domain containing

MSH6 BRPF1

3.16e-03226921147
GeneFamilyPHD finger proteins|Lysine demethylases

KDM2B KDM2A

3.75e-0324692485
GeneFamilyCyclins|Mediator complex

MED24 MED12L

7.02e-03336921061
CoexpressionBUSSLINGER_GASTRIC_IMMUNE_CELLS

MICAL1 MYH9 CYTH1 GRK6 CHD1 RPL14 LAX1 EPG5 KMT2C KIDINS220 ST3GAL5 PIK3CD TRPV2 AHR KDM2A ATM GNAS ASCC3 UTRN

2.33e-0614929819M40023
CoexpressionGSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_TREATED_WITH_DIGOXIN_UP

KMT2C PIK3CD TTLL4 MED12L KDM2A ATM UTRN

5.24e-06180987M8239
CoexpressionGSE16450_IMMATURE_VS_MATURE_NEURON_CELL_LINE_UP

MICAL1 CYTH1 MLXIP ST3GAL5 ATM MPPE1 UTRN

8.85e-06195987M7397
CoexpressionGSE15767_MED_VS_SCS_MAC_LN_DN

HACD3 CYTH1 RPL14 LAX1 MDN1 TRPV2 MPPE1

1.01e-05199987M3585
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

CYTH1 AHCTF1 GRK5 CHD1 TMEM87A LDLR MSH6 KIDINS220 MDN1 ST3GAL5 ARHGAP12 ASCC3 ZBTB11

1.82e-058569813M4500
CoexpressionGSE7219_UNSTIM_VS_LPS_AND_ANTI_CD40_STIM_NIK_NFKB2_KO_DC_UP

CYTH1 GRK6 PLEKHA6 RFX3 ELOVL7 MDN1

5.66e-05178986M383
CoexpressionPTEN_DN.V1_UP

GAL3ST1 NFASC CYP39A1 CD1E TCHH NYNRIN

7.22e-05186986M2787
CoexpressionTGFB_UP.V1_UP

CYTH1 MLXIP CD1E PIK3CD ARHGAP12 CLCF1

7.88e-05189986M2839
CoexpressionHASLINGER_B_CLL_WITH_11Q23_DELETION

AHR PCSK7 ATM

8.50e-0523983M11509
CoexpressionGSE13484_12H_UNSTIM_VS_YF17D_VACCINE_STIM_PBMC_DN

PLEKHA6 JAK2 TTLL4 AHR EXOC2 ABCC2

1.02e-04198986M3273
CoexpressionGSE2706_LPS_VS_R848_AND_LPS_8H_STIM_DC_UP

MYD88 MICAL1 SPATA17 SURF1 COMMD7 AHR

1.02e-04198986M4727
CoexpressionGSE7460_FOXP3_MUT_VS_WT_ACT_TCONV_DN

LRRC66 GRK4 CYP39A1 RFX3 ELOVL7 ATP11C

1.02e-04198986M5701
CoexpressionGSE37532_WT_VS_PPARG_KO_VISCERAL_ADIPOSE_TISSUE_TCONV_UP

MICAL1 CD300A RFX1 KMT2C BRPF1 CLCF1

1.05e-04199986M8964
CoexpressionGSE27786_CD8_TCELL_VS_NKCELL_UP

CYTH1 RPL14 NSUN2 MECR ADAMTS16 MPPE1

1.05e-04199986M4836
CoexpressionZHENG_BOUND_BY_FOXP3

LRRC66 CYTH1 GRK6 RFX3 CADPS AHR CC2D2A EXOC2 UTRN

1.06e-04498989M1741
CoexpressionGSE41867_DAY6_EFFECTOR_VS_DAY30_MEMORY_CD8_TCELL_LCMV_ARMSTRONG_UP

MICAL1 SFI1 TRPV2 MPPE1 UTRN TXLNG

1.08e-04200986M9458
CoexpressionGSE18893_CTRL_VS_TNF_TREATED_TREG_24H_DN

MMS22L CNTLN LDLR KMT2C SURF1 GNAS

1.08e-04200986M7296
CoexpressionGSE3982_BASOPHIL_VS_CENT_MEMORY_CD4_TCELL_DN

HACD3 SFI1 FOCAD CADPS TRPV2 ASCC3

1.08e-04200986M5560
CoexpressionGSE40273_GATA1_KO_VS_WT_TREG_DN

CYTH1 SFI1 KMT2C AHR KDM2B CLCF1

1.08e-04200986M9133
CoexpressionZHENG_BOUND_BY_FOXP3

LRRC66 CYTH1 GRK6 RFX3 CADPS AHR CC2D2A EXOC2 UTRN

1.21e-04507989MM1030
ToppCellfacs-Lung-Endomucin-3m-Myeloid-Myeloid_Dendritic_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DCAF15 MICAL1 MMS22L MLXIP ST3GAL5 ADAMTS16 CLCF1

1.05e-071661017a2ce44702a0cd5fa5872cac3302d3c451205feef
ToppCellfacs-Lung-Endomucin-3m-Myeloid-myeloid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DCAF15 MICAL1 MMS22L MLXIP ST3GAL5 ADAMTS16 CLCF1

1.05e-0716610170f641302a6b71c4badaaf20f51162bfc2386b167
ToppCellILEUM-inflamed-(3)_MNP-(3)_moDC|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

CHD1 AHR PCSK7 KDM2A ATM GNAS UTRN

2.37e-0718710170099def970fbc828756fbf853eca2ce77b8cd342
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

AHCTF1 CHD1 LDLR EPG5 KMT2C ZBTB11 UTRN

2.46e-071881017ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellCOVID-19_Mild|World / Disease condition and Cell class

MYH9 CHD1 LDLR KMT2C AHR KDM2A UTRN

3.49e-07198101761ceb2245b6cb58e308b999a61d218c89dbc615e
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

CYTH1 CHD1 JAK2 KMT2C KDM2A ATM UTRN

3.73e-07200101712f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

CHD1 SFI1 LDLR PCSK7 ATM UTRN

2.59e-0617110162e9a20f8980b78325c52065a9c14ab3656267c05
ToppCellAT1_cells-Donor_03|World / lung cells shred on cell class, cell subclass, sample id

ATP13A4 SLC1A1 LDLR ABCA8 ELOVL7 UTRN

2.78e-0617310163afca2a429c634af0220c1aa19ce4cf4ee3e8b3e
ToppCellIonocyte-iono-2|World / Class top

GRK5 SPTB ELOVL7 KIDINS220 GNAS TMEM117

2.78e-061731016e5ec28ccc5e048fd98de4c876e5c53b866b66228
ToppCellCOPD-Myeloid-ncMonocyte|Myeloid / Disease state, Lineage and Cell class

CD300A AHCTF1 GRK5 CHD1 TMTC1 UTRN

4.76e-061901016ed978cd5d9da87b49878a330e362762c487f849f
ToppCell10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

CHD1 SFI1 LDLR KMT2C KDM2A ATM

5.06e-06192101647646d7e4990be85072987f92bf18d52f8da752e
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

AMACR FAM153B CADPS SV2B LRRC53 MED12L

5.69e-06196101695544097577f20ed7f4144bd940471cde0617554
ToppCellIPF-Endothelial-VE_Peribronchial|Endothelial / Disease state, Lineage and Cell class

CYTH1 AHCTF1 CHD1 ELOVL7 MDN1 ATP11C

6.03e-061981016b8bd1ba268480f54451648e01631b615a3401144
ToppCellCOVID-19|World / Disease, condition lineage and cell class

MYH9 CHD1 KMT2C KDM2A GNAS UTRN

6.39e-0620010167dec470c379cd89f05a0f37c8628b21f136e52f0
ToppCelldroplet-Lung-nan-21m-Myeloid-Intermediate_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP13A4 CD300A GRK5 JAK2 CLCF1

3.21e-0516010150b8151037b28f52a21918856a1e9336e8d5edb90
ToppCelldroplet-Lung-nan-21m-Myeloid-intermediate_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP13A4 CD300A GRK5 JAK2 CLCF1

3.21e-0516010154738d0c73d8c3508e5b5beb6c61e0ad551d9b949
ToppCelldroplet-Lung-21m-Hematologic-myeloid-intermediate_monocyte|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ATP13A4 CD300A GRK5 JAK2 CLCF1

3.62e-051641015cd0794f84dfd346807e2d803723718b7f22e9232
ToppCelldroplet-Lung-21m-Hematologic-myeloid-intermediate_monocyte-intermediate_monocyte_l4|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ATP13A4 CD300A GRK5 JAK2 CLCF1

3.62e-05164101512251a49fd4af32d4edb58046245548c260cf04b
ToppCelldroplet-Lung-nan-3m-Myeloid-myeloid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRRC66 MDN1 ST3GAL5 SV2B KDM2B

3.62e-051641015a67dd181eba275c191f4d0cab13df30eaa3ad913
ToppCellnucseq-Immune-Hematopoietic-Granulocytic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SPTB KCNIP1 LAX1 CADPS MED12L

3.72e-05165101537615622c736e43260c38016e7c9e565ac97a3e8
ToppCellnucseq-Immune-Hematopoietic-Granulocytic-Mast/Basophil|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SPTB KCNIP1 LAX1 CADPS MED12L

3.72e-051651015640bb71e74a61df2fcb01ceeabe4c493ef836b21
ToppCellnucseq-Immune-Hematopoietic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SPTB KCNIP1 LAX1 CADPS MED12L

3.72e-051651015f3df74b5763130c71c0a482a3a23f6b22acc2892
ToppCellControl-Mast_cells|Control / group, cell type (main and fine annotations)

SPTB KCNIP1 LAX1 CADPS MED12L

4.17e-051691015fdb9abca1d0f4fdc32dd8ac6231651ef34aa5afb
ToppCellIonocyte-iono-1|World / Class top

HACD3 ELOVL7 CC2D2A GNAS TMEM117

4.17e-0516910154b68bcb4b5fc3cd2db23cd4edace7444aa2d605c
ToppCellIonocyte|World / Class top

HACD3 ELOVL7 KIDINS220 GNAS TMEM117

4.29e-051701015d2e592f2a679e6a8d32f2b752d9a3c493e50ced4
ToppCellControl-Mast_cells-Mast_cells|Control / group, cell type (main and fine annotations)

SPTB KCNIP1 LAX1 CADPS MED12L

4.29e-051701015c80f6d29096c372da95a8407f402349ff1bb7018
ToppCell10x3'2.3-week_17-19-Neuro|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

CHL1 GAL3ST1 KCNIP1 ABCA8 PLXNB3

4.92e-051751015bbce8b1a160b414c0bf643c21c4e5e78fbccb7e1
ToppCell10x3'2.3-week_17-19-Neuro-stroma-schwann_cells|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

CHL1 GAL3ST1 KCNIP1 ABCA8 PLXNB3

4.92e-0517510158b010220cdfb680ec839572f4933adfb85045ea6
ToppCell10x3'2.3-week_17-19-Neuro-stroma|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

CHL1 GAL3ST1 KCNIP1 ABCA8 PLXNB3

4.92e-0517510150b579aeadcc06be83627391c0b01bd8605fdbdf3
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

ATP13A4 KCNIP1 SLC1A1 ABCA8 FYB2

5.48e-0517910154f6ca313b78aa93557937a046c44dcf8bcc9963c
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP13A4 ABCA4 SFI1 ADAMTS16 ROS1

6.25e-0518410152cbed6462fea2622871bb7e49b0df3d984239281
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT1-AT1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ATP13A4 GRK5 KCNIP1 SLC1A1 UTRN

6.25e-05184101557c792e6e2fedba25d3350ffe649fd74750b579d
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP13A4 ABCA4 SFI1 ADAMTS16 ROS1

6.25e-051841015ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP13A4 ABCA4 SFI1 ADAMTS16 ROS1

6.25e-0518410152b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_1-D122|Adult / Lineage, Cell type, age group and donor

ATP13A4 KCNIP1 SLC1A1 ABCA8 FYB2

6.25e-051841015561592edc3083fad41b91811151b442207c65dd9
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ATP13A4 GRK5 KCNIP1 SLC1A1 UTRN

6.25e-051841015d7bd0f0c607bade67c99e9fb3578a570298bf926
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1|Children_(3_yrs) / Lineage, Cell type, age group and donor

ATP13A4 GRK5 KCNIP1 SLC1A1 FYB2

6.41e-0518510151c222f7285d6e3dae0354dc7e853ddc0ea55e63e
ToppCellCV-Moderate-7|Moderate / Virus stimulation, Condition and Cluster

MMS22L AHCTF1 SFI1 LDLR KIDINS220

6.41e-051851015a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCellCV-Moderate-7|CV / Virus stimulation, Condition and Cluster

MMS22L AHCTF1 SFI1 MSH6 KIDINS220

6.57e-0518610158571956890fc9894d766ba294a28e376b4aba428
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

ATP13A4 GRK5 KCNIP1 SLC1A1 FYB2

6.74e-051871015d4b0afd9b92c47c8aa348bbd1af7eb54c3d478f2
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_1|Adult / Lineage, Cell type, age group and donor

ATP13A4 GRK5 KCNIP1 SLC1A1 ABCA8

6.74e-05187101577f78aec946bc6bd85c29aee9ca978ce49f853a3
ToppCell5'-Airway_Nasal-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells-Mast_cells_L.1.4.0.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KCNIP1 LAX1 ARHGEF40 CADPS AHR

7.09e-051891015aba941ba6ce7702418b3f470bde573d123c4aade
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51|PBMC_fresh-frozen / Compartment, severity and other cell annotations on 10x 3' data (130k)

CYTH1 PCSK7 ATM GNAS UTRN

7.09e-0518910150e8d1be3c406d1a393e18faccfe89116a8f82bcf
ToppCellCOPD-Myeloid-ncMonocyte|World / Disease state, Lineage and Cell class

CD300A AHCTF1 CHD1 TMTC1 UTRN

7.27e-051901015aece860b5609ad5a8fc920d685f0d0ec71bf9018
ToppCellCOVID-19-Heart-CM_4|Heart / Disease (COVID-19 only), tissue and cell type

SPTB LDLR FAM153B CADPS FYB2

7.27e-0519010153729648a17093b438398b82e32bbccc3af7b8c5d
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

GRK5 NFASC KCNIP1 ABCA8 TMTC1

7.45e-051911015a58c75e9580139fb370b498d95660f10f3a2a27b
ToppCellCD8+_Memory_T_cell-CV-7|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

MMS22L AHCTF1 SFI1 LDLR KIDINS220

7.45e-0519110159454f642c3621370fa23640b631301346b300950
ToppCell5'-Airway_Nasal-Immune_Myeloid_mast-Myeloid_Mast/Baso|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KCNIP1 LAX1 ARHGEF40 CADPS AHR

7.64e-051921015690cf19e9b0b2ada80097c63eae827529aa5b6f3
ToppCellIPF-Epithelial-Club|Epithelial / Disease state, Lineage and Cell class

ATP13A4 LDLR ST3GAL5 AHR ROS1

7.64e-051921015356e7a820b744a0ac87352a8d0e6e8d9fa9ed7d2
ToppCell5'-Airway_Nasal-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KCNIP1 LAX1 ARHGEF40 CADPS AHR

7.64e-0519210153d6c4c5847ca1e44fa380403d25af45d5b51ee9b
ToppCell5'-Airway_Nasal-Immune_Myeloid_mast|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KCNIP1 LAX1 ARHGEF40 CADPS AHR

7.64e-051921015e0412964a3ee1bf3c0ef64f9a6f20f7e7835701e
ToppCell5'-Airway_Nasal-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KCNIP1 LAX1 ARHGEF40 CADPS AHR

7.64e-051921015b5871247a5f3e970fa05b33fff21bef9d2ab5741
ToppCellCOPD-Myeloid-ncMonocyte|COPD / Disease state, Lineage and Cell class

CD300A AHCTF1 CHD1 TMTC1 UTRN

7.82e-051931015936ca95995599356b794fba32bfd82d8de339365
ToppCellsevere-low-quality_cells|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SFI1 RFX3 PCSK7 ATM UTRN

7.82e-0519310159337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCellmild-low-quality_cells|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

LRRC66 SFI1 PCSK7 ATM UTRN

8.62e-051971015e4331969bd911d1ebb5453f40a7057297b5389b4
ToppCellParenchymal-NucSeq-Epithelial-Epi_alveolar-AT1|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ATP13A4 GRK5 KCNIP1 SLC1A1 ABCA8

8.62e-0519710158d5097898dd01cedb04cb694cb480c931e08462c
ToppCellCOVID-19_Mild|World / Disease group, lineage and cell class

CHD1 KMT2C KDM2A GNAS UTRN

8.62e-0519710155c33454b10023decd2f5ccda9229b6512659711e
ToppCellPBMC-Mild|PBMC / Location, Disease Group, Cell group, Cell class (2021.03.09)

CHD1 KMT2C KDM2A GNAS UTRN

8.83e-05198101544417089b62056269cac38d3134ff209c05b7007
ToppCellPBMC-Mild|PBMC / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CHD1 KMT2C KDM2A GNAS UTRN

8.83e-05198101528ef3fc4c17dcb765537b75917f7db78baa522db
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CHL1 GAL3ST1 KCNIP1 LDLR PLXNB3

9.04e-051991015333056c2abe9724efeab542c0365fcfe4eff8f18
ToppCellASK452-Epithelial-Type_1|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq

SLC1A1 LDLR ABCA8 AHR UTRN

9.04e-05199101548cafe44951908d03f3c6f3e185e9cbb86fb5b3b
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CHL1 GAL3ST1 KCNIP1 LDLR PLXNB3

9.04e-051991015e60ecbb8fa7bcd3e2ce7d78f6efb2cfd1fd77698
ToppCell5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ATP13A4 TMEM87A LDLR ST3GAL5 ROS1

9.04e-0519910152dc33804f6691d7c9682e6c9b885e945fb97fc36
ToppCellBrain_organoid-organoid_Tanaka_cellReport-6m-Mesenchymal-BMP_responsible_cell|6m / Sample Type, Dataset, Time_group, and Cell type.

ABCA4 FOCAD SPATA17 ATP11C FYB2

9.25e-0520010155fb90118d3abc28d72bc483e68317255090a04c7
ToppCellParenchymal-10x3prime_v2-Immune_Myeloid-Myeloid-Megakaryocyte|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

GRK6 SFI1 LAX1 KIDINS220 COMMD7

9.25e-0520010150d76b006d8e8b32174e65e400acd0674354b962c
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CHL1 GAL3ST1 KCNIP1 LDLR PLXNB3

9.25e-052001015ad777683adeb2ce45ade570386235e311fa7ea2d
ToppCellParenchymal-10x3prime_v2-Immune_Myeloid-Myeloid|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

GRK6 SFI1 LAX1 KIDINS220 COMMD7

9.25e-052001015cc8368665bc6bb7c4f39632ccff07ceaa98a7b65
ToppCellBrain_organoid-organoid_Tanaka_cellReport-2m-Mesenchymal-Cilia-bearing_cell|2m / Sample Type, Dataset, Time_group, and Cell type.

ABCA4 SPATA17 TTLL4 ATP11C TMEM117

9.25e-052001015c6060205cab46628d845edbf17e2c5be7508181c
ToppCellCOVID-19-COVID-19_Mild|COVID-19 / Disease, condition lineage and cell class

CYTH1 CHD1 PCSK7 GNAS UTRN

9.25e-05200101562c25042086f1afd1102e0720e933c2e476468fd
DrugImipenem [74431-23-5]; Up 200; 13.4uM; HL60; HG-U133A

GRK6 SFI1 ARHGEF40 CATSPER2 TTLL4 AHR KDM2A CLCF1

3.10e-0620010181724_UP
DiseaseIntellectual Disability

CHL1 GRIN2D NSUN2 KMT2C ST3GAL5 SURF1 MED12L GNAS ASCC3 ZBTB11

2.46e-064479810C3714756
Diseaselung non-small cell carcinoma (is_implicated_in)

MYD88 JAK2 KMT2C KDM2A ATM ABCC2

7.23e-06139986DOID:3908 (is_implicated_in)
DiseaseColorectal Carcinoma

CHL1 ABCA4 AMACR CHD1 ABCA8 MSH6 KMT2C ATP11C KDM2A GNAS ABCC2

2.19e-057029811C0009402
DiseaseNon-alcoholic Fatty Liver Disease

LDLR JAK2 AHR ABCC2

8.87e-0570984C0400966
DiseaseNonalcoholic Steatohepatitis

LDLR JAK2 AHR ABCC2

8.87e-0570984C3241937
Diseaseobsessive-compulsive symptom measurement

ATP13A4 TMTC1 CADPS

1.49e-0431983EFO_0007802
Diseasedisease of cellular proliferation (implicated_via_orthology)

JAK2 ATM

2.27e-047982DOID:14566 (implicated_via_orthology)
DiseaseMASA syndrome (implicated_via_orthology)

CHL1 NFASC

2.27e-047982DOID:0060246 (implicated_via_orthology)
Diseaseendometrial cancer (is_implicated_in)

MSH6 PIK3CD ATM

2.34e-0436983DOID:1380 (is_implicated_in)
Diseasevisceral heterotaxy (implicated_via_orthology)

RFX3 MEGF8 CC2D2A

2.54e-0437983DOID:0050545 (implicated_via_orthology)
DiseaseColorectal Neoplasms

ABCA4 AMACR CHD1 ABCA8 KDM2A ABCC2

3.31e-04277986C0009404
DiseaseLiver Diseases, Parasitic

KMT2C GNAS

3.87e-049982C0023897
Diseasenasopharynx carcinoma (is_marker_for)

JAK2 KMT2C ATM

3.98e-0443983DOID:9261 (is_marker_for)
DiseaseGastric Adenocarcinoma

GRK6 ROS1 ATM

4.56e-0445983C0278701
DiseaseAtrophic

SLC1A1 AHR

4.83e-0410982C0333641
Diseaseapolipoprotein B to apolipoprotein A1 ratio

LDLR ABCA8 PCSK7

5.86e-0449983EFO_0021897
DiseaseSchizophrenia

CHL1 AMACR GRK6 NFASC PLEKHA6 GRIN2D SLC1A1 KDM2B ATM GNAS

7.13e-048839810C0036341
Diseaseleukemia

JAK2 MSH6 ATM

8.22e-0455983C0023418
DiseaseDiffuse Large B-Cell Lymphoma

MYD88 JAK2 PIK3CD

8.22e-0455983C0079744
Diseasemelanoma

PLEKHA6 AHR ATM EXOC2

8.40e-04126984EFO_0000756
DiseaseProstatic Neoplasms

AMACR CHD1 JAK2 KMT2C PIK3CD BRPF1 AHR ATM

1.05e-03616988C0033578
DiseaseMalignant neoplasm of prostate

AMACR CHD1 JAK2 KMT2C PIK3CD BRPF1 AHR ATM

1.05e-03616988C0376358
Diseaselymphocyte count

MMS22L GRK5 SPTB SFI1 PLEKHA6 LAX1 FOCAD CERS5 ST3GAL5 PIK3CD MED12L ATM CLCF1

1.11e-0314649813EFO_0004587
Diseaselysophosphatidylethanolamine 18:0 measurement

TMTC1 ADAMTS16

1.11e-0315982EFO_0010367
DiseaseProfound Mental Retardation

CHL1 SURF1 GNAS ASCC3

1.21e-03139984C0020796
DiseaseMental Retardation, Psychosocial

CHL1 SURF1 GNAS ASCC3

1.21e-03139984C0025363
DiseaseMental deficiency

CHL1 SURF1 GNAS ASCC3

1.21e-03139984C0917816
Diseaseresponse to antineoplastic agent, response to antimicrotubule agent

MLXIP AHR

1.27e-0316982EFO_0005260, GO_0097327
DiseaseMalignant lymphoma, lymphocytic, intermediate differentiation, diffuse

PIK3CD ATM

1.27e-0316982C0334634
Diseasemean reticulocyte volume

MYH9 SPTB CHD1 MLXIP JAK2 NYNRIN CC2D2A ATM IPO11

1.38e-03799989EFO_0010701
Diseasebreast carcinoma (is_marker_for)

AMACR MSH6 ATM

1.40e-0366983DOID:3459 (is_marker_for)
DiseaseTachycardia

AHR GNAS

1.61e-0318982C0039231
DiseaseTachyarrhythmia

AHR GNAS

1.61e-0318982C0080203
Diseasecholesteryl ester measurement

CYP39A1 LDLR ABCA8 NYNRIN PCSK7

1.69e-03257985EFO_0010351
DiseaseLiver diseases

AMACR GRK5 AHR

1.79e-0372983C0023895
DiseaseLiver Dysfunction

AMACR GRK5 AHR

1.79e-0372983C0086565
Diseasemean platelet volume

LRRC66 MICAL1 MYH9 GRK4 GRK5 NFASC ELOVL7 JAK2 ST3GAL5 GNAS

2.09e-0310209810EFO_0004584
Diseaseepilepsy (implicated_via_orthology)

CHL1 NFASC GRIN2D SLC1A1

2.17e-03163984DOID:1826 (implicated_via_orthology)
Diseasecholangiocarcinoma (is_implicated_in)

GNAS ABCC2

2.42e-0322982DOID:4947 (is_implicated_in)
Diseasecolorectal carcinoma (is_implicated_in)

MYD88 MSH6

2.42e-0322982DOID:0080199 (is_implicated_in)
Diseaserisky sexual behaviour measurement

MMS22L GRK5 NFASC ASCC3

2.47e-03169984EFO_0007877
DiseaseImmunologic Deficiency Syndromes

EPG5 ATM

2.64e-0323982C0021051
DiseaseQRS duration, response to sulfonylurea

CNTLN MDN1

2.64e-0323982EFO_0005055, EFO_0007922
DiseaseIntrahepatic Cholangiocarcinoma

KMT2C GNAS

2.87e-0324982C0345905
DiseaseExtrahepatic Cholangiocarcinoma

KMT2C GNAS

2.87e-0324982C3805278
DiseaseDyslipidemias

LDLR AHR

2.87e-0324982C0242339
DiseaseDyslipoproteinemias

LDLR AHR

2.87e-0324982C0598784
Diseasemyeloproliferative disorder

JAK2 ATM

3.12e-0325982EFO_0004251

Protein segments in the cluster

PeptideGeneStartEntry
FRLLTKNNRWTWVQS

AHR

351

P35869
QWAWNLILRLKLHKN

EPG5

966

Q9HCE0
KLFLWWHQVLQLSLI

EPG5

2416

Q9HCE0
LKWTSSIAQLLWRQA

ARHGEF40

1361

Q8TER5
ILLKWLSNFSVFWKS

CATSPER2

161

Q96P56
ADKEFVWSLWKRLQV

CNTLN

121

Q9NXG0
QIQLLLWKNWTLRKR

ABCA4

6

P78363
WKKVIWIYLSALNSA

ATP13A4

86

Q4VNC1
LSSFLWKTQKLSLWE

AMACR

191

Q9UHK6
RWQKIFSFNVWGKIA

BCAP29

31

Q9UHQ4
EVWLTFQQKWIFLNK

DNHD1

1256

Q96M86
LQVRRSFKTWWQKKP

DNHD1

2781

Q96M86
IKQWRKNLWIFVSKF

CHD1

1471

O14646
LSKQLDWNVRKIQCW

CERS5

111

Q8N5B7
KKLQWLVSAWSQCSV

ADAMTS16

1051

Q8TE57
NILWKLEVAKQLAWA

JAK2

646

O60674
IDVWKKWTTLNSLQL

NSUN2

281

Q08J23
WKRWKKRFFVLVQVS

CADPS

536

Q9ULU8
WWQVLDSLLNSQRKR

KIDINS220

711

Q9ULH0
VASQWTLKKSLLQAW

MDN1

2851

Q9NU22
WTTRVKQIAKLWRKA

KMT2C

1671

Q8NEZ4
WTLRQSWLELQLMIK

MED12L

1321

Q86YW9
RLKGYQINWWKTKSL

CHL1

841

O00533
QINWWKTKSLLDGRT

CHL1

846

O00533
TVQKKVSQWWERLTK

HACD3

81

Q9P035
FVSESFWNWLNKLLK

MMS22L

311

Q6ZRQ5
FWNWLNKLLKTLLEK

MMS22L

316

Q6ZRQ5
WFTNSWVLKRKRTPQ

LRRC53

691

A6NM62
VIWLIGQWISVKFKS

IPO11

496

Q9UI26
VLSREASQKLLWWLQ

MPPE1

281

Q53F39
LLNAWRLVNAAKIWT

PCSK7

466

Q16549
TLHIWKTNSLLLRFW

PLXNB3

1746

Q9ULL4
TKLVLSQLPNFWKLW

EXOC2

456

Q96KP1
LWLLKKSNRYSLTIW

FAM151B

216

Q6UXP7
KTWKRRWFILTDNCL

CYTH1

276

Q15438
FWVLNLTTLQWRQEK

MEGF8

1596

Q7Z7M0
VVAVFCILWNWNKRK

LAX1

51

Q8IWV1
TKSWFWTRLAKALSL

MYD88

281

Q99836
IKDQLNYWSAKSLWT

MICAL1

51

Q8TDZ2
QKNSWFLSLFWILSI

ABCC2

126

Q92887
QWWRLFTKVKPLLQV

MYH9

826

P35579
RKWWQIKSQNFDLVI

MSH6

411

P52701
LQTKQRRPSKDIAWW

KCNIP1

11

Q9NZI2
QNFISESWRKKWNVI

LRRC66

266

Q68CR7
RRATLWIPQWFAKKA

SMPD4

16

Q9NXE4
KVRKNWLSSWAVLQG

ARHGAP12

481

Q8IWW6
TRTLQNWKFWIFSII

MLXIP

826

Q9HAP2
WRESSLLKNLWVSQK

NFASC

866

O94856
ANLWVTKLWKFIRDF

GAL3ST1

406

Q99999
LKLWNKIWCITFRGI

ATM

481

Q13315
LAQVSWIKNRVLKKW

CD1E

366

P15812
WTNISKKQLTWLVNR

KDM2A

961

Q9Y2K7
LSWTNISKKQLSWLI

KDM2B

1131

Q8NHM5
TSLQQWKAWRKVQRA

CC2D2A

576

Q9P2K1
LWWKKYLTSLQLVQF

ELOVL7

201

A1L3X0
QRIISWVFFWRQKIK

C7orf61

16

Q8IZ16
EKWKQNAPTLARWAI

COMMD7

111

Q86VX2
NLFKSIWNNRWLRTI

GNAS

271

P63092
LLRNWSKSKKWFLEL

CYP39A1

211

Q9NYL5
IFKDLKLRGFWLSQW

MECR

301

Q9BV79
RFVLEWTWNKVVLTK

AHCTF1

581

Q8WYP5
FLQWKWLERQPVTKN

GRK4

171

P32298
LQWKWLERQPVTKNT

GRK5

171

P34947
LQWKWLERQPVTKNT

GRK6

171

P43250
WWEFNVHSKLKLVRQ

DCAF15

111

Q66K64
WKRFLKNNWVLLSTV

SLC1A1

11

P43005
WKEQTQKFIDWLFSI

FOCAD

1746

Q5VW36
KKSRWNVLKCWDIFN

FAM153B

371

P0C7A2
SKAWLIRWSLLVQDK

NYNRIN

1251

Q9P2P1
WGNKTLKQTFLSVLW

TAS2R20

281

P59543
WGNKKLKQTFLSVLW

TAS2R46

281

P59540
SLQAKVWATWLAFVL

SFI1

851

A8K8P3
NRIVTIIQKWWRSFL

SPATA17

56

Q96L03
SAELLNWILKWKTAI

UTRN

696

P46939
NWILKWKTAIQTTEI

UTRN

701

P46939
RQSTILKRWKKNWFD

PLEKHB2

11

Q96CS7
QRWLVRFKTIFKQVW

SV2B

361

Q7L1I2
LQFTLVETLWKTFWR

RFX1

626

P22670
LQFSLIEKLWQTFWR

RFX3

371

P48380
FRNKLWNWEKVSSQK

FYB2

136

Q5VWT5
FKSIWNNRWLRTISV

GNAS

916

Q5JWF2
LKQAILQAWKERWSD

MED24

6

O75448
WVRLFFWKQVAEKIP

ST3GAL5

286

Q9UNP4
LGTWQVQRRKWKLNL

SURF1

76

Q15526
QLLKESLWKISDVAW

MROH2B

576

Q7Z745
QTWALLCKNFLKKWR

ABCA8

11

O94911
NWALKEQLKSWQRLR

BRPF1

581

P55201
NLSKVIDKRLWGWAS

ASCC3

1111

Q8N3C0
ASLLAWRMFQKWIKA

CD300A

196

Q9UGN4
LQTWLWRSAKDFNRL

CLCF1

191

Q9UBD9
TLKLALDTRFWTWIN

ATP11C

1011

Q8NB49
SSGVKQWNKRWFVLV

PLEKHA6

71

Q9Y2H5
LSKTYWWRGILKQVK

ZBTB11

96

O95625
LLLFSWKTVKQNEIW

TMTC1

451

Q8IUR5
DINTKWAATRWAKKI

RPL14

81

P50914
KWNRLLQKGWVDLFV

SERPINA7

291

P05543
SWSIWKLQKAISVLE

TRPV2

656

Q9Y5S1
EALRESWKTKVNWLA

PIK3CD

1021

O00329
NWDKWLSRRFQKVKL

TBC1D10B

341

Q4KMP7
NVNLIRFWVELQKWK

ROS1

1681

P08922
AQLEQSKRLWKFFWE

SPTB

631

P11277
LAIAQVWLWVSLAKA

UNQ9370/PRO34162

36

Q6UXP9
FWKKGNVRITLFWTV

TMEM117

191

Q9H0C3
TIIWRTKWENNNKAL

TXLNG

396

Q9NUQ3
LRKAWESSSRQKWIV

TTLL4

706

Q14679
RIKSRIPKWQWQLES

TCHH

696

Q07283
WWIFISLTQTMKLLK

TMEM87A

376

Q8NBN3
VFLLWKNWRLKNINS

LDLR

806

P01130
KSIWLLWALVFNNSV

GRIN2D

631

O15399