Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	Leu-rich_rpt	LRRC25 SLIT1 NXF5 NLRP1 LRRC4 LRRC17	2.75e-04	271	62	6	IPR001611
Domain	MFS	SLC2A8 SLC22A5 SLCO4A1 SLCO1B3	4.56e-04	108	62	4	PS50850
Domain	LRR	SLIT1 NXF5 NLRP1 LRRC4 LRRC17	5.40e-04	201	62	5	PS51450
Domain	-	LRRC25 SLIT1 NXF5 NLRP1 LRRC4 LRRC17	6.73e-04	321	62	6	3.80.10.10
Domain	OA_transporter	SLCO4A1 SLCO1B3	7.00e-04	12	62	2	IPR004156
Domain	OATP	SLCO4A1 SLCO1B3	7.00e-04	12	62	2	PF03137
Domain	L_dom-like	LRRC25 SLIT1 NXF5 NLRP1 LRRC4 LRRC17	7.54e-04	328	62	6	IPR032675
Domain	MFS_dom	SLC2A8 SLC22A5 SLCO4A1 SLCO1B3	1.02e-03	134	62	4	IPR020846
Domain	Synaptotagmin	SYT3 SYT9	1.98e-03	20	62	2	IPR001565
Domain	BRCT	LIG3 CTDP1	2.40e-03	22	62	2	SM00292
Domain	PWWP	NSD1 PWWP3A	2.62e-03	23	62	2	PF00855
Domain	PWWP_dom	NSD1 PWWP3A	2.62e-03	23	62	2	IPR000313
Domain	-	LIG3 CTDP1	2.62e-03	23	62	2	3.40.50.10190
Domain	PWWP	NSD1 PWWP3A	2.85e-03	24	62	2	PS50812
Domain	SUGAR_TRANSPORT_1	SLC2A8 SLC22A5	2.85e-03	24	62	2	PS00216
Domain	CTCK_2	DAND5 SLIT1	3.10e-03	25	62	2	PS01225
Domain	Cys-rich_flank_reg_C	SLIT1 LRRC4 LRRC17	3.33e-03	90	62	3	IPR000483
Domain	LRRCT	SLIT1 LRRC4 LRRC17	3.33e-03	90	62	3	SM00082
Domain	BRCT	LIG3 CTDP1	3.35e-03	26	62	2	PS50172
Domain	Bromodomain_CS	BAZ2B PHIP	3.35e-03	26	62	2	IPR018359
Domain	BRCT_dom	LIG3 CTDP1	3.88e-03	28	62	2	IPR001357
Domain	Sugar_transporter_CS	SLC2A8 SLC22A5	5.04e-03	32	62	2	IPR005829
Domain	LRR_1	SLIT1 NLRP1 LRRC4 LRRC17	6.03e-03	219	62	4	PF00560
Domain	MFS_sugar_transport-like	SLC2A8 SLC22A5	6.35e-03	36	62	2	IPR005828
Domain	Sugar_tr	SLC2A8 SLC22A5	6.35e-03	36	62	2	PF00083
Domain	Kazal_2	SLCO4A1 SLCO1B3	6.35e-03	36	62	2	PF07648
Domain	BROMODOMAIN_1	BAZ2B PHIP	6.70e-03	37	62	2	PS00633
Domain	Bromodomain	BAZ2B PHIP	7.06e-03	38	62	2	PF00439
Domain	BROMODOMAIN_2	BAZ2B PHIP	8.18e-03	41	62	2	PS50014
Domain	BROMO	BAZ2B PHIP	8.57e-03	42	62	2	SM00297
Domain	Bromodomain	BAZ2B PHIP	8.57e-03	42	62	2	IPR001487
Domain	-	BAZ2B PHIP	8.57e-03	42	62	2	1.20.920.10
Pathway	REACTOME_SLC_TRANSPORTER_DISORDERS	AAAS SLC22A5 SLC6A5 SLCO1B3 SLC3A2	3.09e-05	99	52	5	M27474
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TAOK2 NADSYN1 LMAN2L DNAJC14 CTDP1 RDH10 NSD1 SLCO4A1 MED13L ADCY9	2.79e-05	1105	63	10	35748872
Pubmed	Cyclin O (Ccno) functions during deuterosome-mediated centriole amplification of multiciliated cells.	DAND5 DNAH5	3.22e-05	5	63	2	25712475
Pubmed	Toxicity and therapy outcome associations in LIG3, SLCO1B3, ABCB1, OPRM1 and GSTP1 in high-grade serous ovarian cancer.	LIG3 SLCO1B3	3.22e-05	5	63	2	36988399
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	MYO7B CTDP1 NSD1 DNAH5 VPS13B	6.76e-05	234	63	5	36243803
Pubmed	Broad mesodermal and endodermal deletion of Nodal at postgastrulation stages results solely in left/right axial defects.	DAND5 DNAH5	8.98e-05	8	63	2	18773491
Pubmed	WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding.	SYT3 SYT9	8.98e-05	8	63	2	15350218
Pubmed	Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters.	SLCO4A1 SLCO1B3	8.98e-05	8	63	2	19129463
Pubmed	Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X.	SYT3 SYT9	1.15e-04	9	63	2	10531343
Pubmed	The expression of thyroid hormone transporters in the human fetal cerebral cortex during early development and in N-Tera-2 neurodifferentiation.	SLCO4A1 SLC3A2	1.15e-04	9	63	2	21486766
Pubmed	Distinct developmental expression of synaptotagmin I and IX in the mouse brain.	SYT3 SYT9	1.15e-04	9	63	2	16407767
Pubmed	SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms.	SYT3 SYT9	1.76e-04	11	63	2	10734137
Pubmed	Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties.	SLCO4A1 SLCO1B3	1.76e-04	11	63	2	14579113
Pubmed	The mouse homeobox gene Noto regulates node morphogenesis, notochordal ciliogenesis, and left right patterning.	DAND5 DNAH5	2.49e-04	13	63	2	17884984
Pubmed	Genomic analysis of synaptotagmin genes.	SYT3 SYT9	2.49e-04	13	63	2	11543631
Pubmed	Localization of Xenobiotic Transporters Expressed at the Human Blood-Testis Barrier.	SLC22A5 SLCO1B3	3.81e-04	16	63	2	35307651
Pubmed	Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.	SULT2B1 SLC22A5 SLCO4A1 SLCO1B3	4.24e-04	193	63	4	19343046
Pubmed	Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.	SLC22A5 SLIT1 SYT9 SNTG1	4.76e-04	199	63	4	23382691
Pubmed	Identification of Peroxisomal Protein Complexes with PTS Receptors, Pex5 and Pex7, in Mammalian Cells.	PEX2 TYSND1	1.02e-03	26	63	2	30378028
Pubmed	Identification by proximity labeling of novel lipidic and proteinaceous potential partners of the dopamine transporter.	SLC6A5 SLC3A2	1.10e-03	27	63	2	34709416
Pubmed	Two proteases, trypsin domain-containing 1 (Tysnd1) and peroxisomal lon protease (PsLon), cooperatively regulate fatty acid β-oxidation in peroxisomal matrix.	PEX2 TYSND1	1.18e-03	28	63	2	22002062
Pubmed	Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.	GIPR ADCY9	1.18e-03	28	63	2	24861553
Pubmed	Defining the membrane proteome of NK cells.	NRM AAAS DNAJC14 G6PC3 INPP5K PEX2 TYSND1 SLC3A2	1.19e-03	1168	63	8	19946888
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	LIG3 NSD1 PWWP3A MED13L SLC3A2	1.39e-03	453	63	5	29656893
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	DNAJC14 G6PC3 SLC2A8 SLCO4A1 SLC3A2 TMEM63A	1.63e-03	697	63	6	28298427
Pubmed	GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.	PEX2 DEGS2	1.64e-03	33	63	2	21658281
Cytoband	12p11.21	IPO8 ETFBKMT	4.21e-04	22	63	2	12p11.21
GeneFamily	Solute carriers	SLC2A8 SLC22A5 SLC6A5 SLCO4A1 SLCO1B3 SLC3A2	5.92e-04	395	48	6	752
GeneFamily	Synaptotagmins	SYT3 SYT9	9.15e-04	17	48	2	765
GeneFamily	PWWP domain containing	NSD1 PWWP3A	1.54e-03	22	48	2	1147
Drug	Metronidazole [443-48-1]; Down 200; 23.4uM; HL60; HG-U133A	TAOK2 LIG3 AAAS NADSYN1 LMAN2L G6PC3	1.60e-05	197	62	6	2003_DN
Drug	Picotamide monohydrate [80530-63-8]; Down 200; 10.2uM; MCF7; HT_HG-U133A	AAAS CTDP1 PWWP3A ANKMY1 ADCY9 TMEM63A	1.60e-05	197	62	6	6787_DN
Drug	Monensin sodium salt [22373-78-0]; Down 200; 5.8uM; MCF7; HT_HG-U133A	SULT2B1 NSD1 FAXDC2 PWWP3A MTMR9 TMEM63A	1.60e-05	197	62	6	3443_DN
Drug	Budesonide [51333-22-3]; Down 200; 9.2uM; MCF7; HT_HG-U133A	TAOK2 IPO8 INPP5K CTDP1 FAXDC2 TMEM63A	1.64e-05	198	62	6	5431_DN
Drug	Amrinone [60719-84-8]; Down 200; 21.4uM; HL60; HT_HG-U133A	INPP5K FAXDC2 NLRP1 ANKMY1 ADCY9 TMEM63A	1.64e-05	198	62	6	2724_DN
Drug	estradiol, USP; Up 200; 0.01uM; HL60; HT_HG-U133A	IPO8 ANKMY1 IL5RA VPS13B ADCY9 SGK2	1.64e-05	198	62	6	6200_UP
Drug	Biperiden hydrochloride [1235-82-1]; Up 200; 11.4uM; HL60; HT_HG-U133A	LIG3 SLC2A8 INPP5K SLC22A5 CTDP1 TMEM63A	1.64e-05	198	62	6	2460_UP
Disease	waist circumference	TAOK2 GIPR SYT3 SLIT1 SNTG1 DNAH5 PHIP ADCY9	3.18e-06	429	62	8	EFO_0004342
Disease	deoxycholic acid glucuronide measurement	TMPRSS11E SLCO1B3	1.21e-04	8	62	2	EFO_0800575

Protein segments in the cluster

Peptide	Gene	Start	Entry
EAGLCKPLWAWWELQ	nan	86	Q9HAA7
VNPDWLWSCLERWDK	CTDP1	706	Q9Y5B0
VWKRCINIWRDVGLF	AAAS	76	Q9NRG9
FGWWRIIDPEDLKAL	BAZ2B	1716	Q9UIF8
CWERNEVKAIWWIIR	GIPR	286	P48546
LIWAKFKRRPWWPCR	NSD1	326	Q96L73
WVKVGRYRWWPAEIC	NSD1	1761	Q96L73
ARKRWAPVVLWCLTG	DAND5	151	Q8N907
VRIVQWGWLELPWVK	DNAJC14	391	Q6Y2X3
VKPDCKELWIFWWGD	MED13L	76	Q71F56
KWEAPVFLLFLDCVW	MTMR9	391	Q96QG7
FLKLLWLRDNPWRCD	LRRC17	341	Q8N6Y2
IAGPVLAWRLWRCRV	LRRC25	181	Q8N386
WSISLAFKWCERPEW	G6PC3	226	Q9BUM1
GPESQRWWCLLSLKW	NXF5	356	Q9H1B4
RWWCLLSLKWKDGLR	NXF5	361	Q9H1B4
RFEPEVKACLWVFLW	PEX2	51	P28328
KELWALCLVPWVSWL	NLRP1	511	Q9C000
CDILWLAWWLREYIP	LRRC4	306	Q9HBW1
GALWNRVPCFLRDWE	LMAN2L	96	Q9H0V9
WEARAEPWATWVPLL	NRM	126	Q8IXM6
RKGRVSVPLRQACWW	PDPK2P	381	Q6A1A2
ICWKNLSIQGLRWWL	TMEM63A	406	O94886
VSPEWIWACIRKRRL	LIG3	991	P49916
LGLGRLLCWWWLAEL	HHAT	246	Q5VTY9
DRVVCWWPLVNDDAW	WDPCP	236	O95876
WWRDPCRRELPTFHW	FAXDC2	156	Q96IV6
CWFPRTFILSKGRDW	IL5RA	196	Q01344
AWTDRILWRLKRQPC	INPP5K	266	Q9BT40
LACWLVRGLAWRWLL	DEGS2	56	Q6QHC5
PGWVRTRWALLLLFW	SLC3A2	176	P08195
CTKRLLEWIAGWLPR	ADCY9	851	O60503
WDPTWLYLCKRAELI	ANKMY1	836	Q9P2S6
LWPFKETVRKCARSW	MAN2C1	266	Q9NTJ4
EIQLRLLTPRCKFWW	ETFBKMT	66	Q8IXQ9
LLTPRCKFWWERADL	ETFBKMT	71	Q8IXQ9
VALWWFIPESPRWLI	SLC22A5	271	O76082
TWAWRAPVELFLLCA	C8B	6	P07358
FDARIPAWWKKASWI	DNAH5	4436	Q8TE73
DDRPELVWWKCKKWA	IPO8	251	O15397
YVLCRWEKRLWPAKV	PWWP3A	6	Q2TAK8
SLFVSWKLCWVPWRD	SYT3	71	Q9BQG1
LFVSWKLCWVPWRER	SYT9	71	Q86SS6
LFDKRCWLWVWEAFV	TAS2R16	251	Q9NYV7
RPSCVDASIVIGKWW	TAFA1	81	Q7Z5A9
WIRSVPIWERAPWCE	SULT2B1	91	O00204
LRKEPYDRAVDWWCL	SGK2	206	Q9HBY8
WAVFAPIWLWKLLVV	TMEM185B	41	Q9H7F4
EIRWPLALCLFLAWV	SLC6A5	391	Q9Y345
DWERPWQVWPISCTL	PIGF	176	Q07326
GLRWEKRWCDLRLIP	SNTG1	196	Q9NSN8
RLVVWLPDVPADLWW	PNPLA5	361	Q7Z6Z6
GWVLEWRWLAVLGCV	SLC2A8	176	Q9NY64
LLARVWVLCKGWNWR	TAOK2	1146	Q9UL54
WAFVLAAARWLVRPK	RDH10	16	Q8IZV5
PIAFGWVIDKACLLW	SLCO4A1	631	Q96BD0
WCWALALLWLAVVPG	CLN5	26	O75503
DVVRARKRVCWEPWV	TMPRSS11E	6	Q9UL52
RKRVCWEPWVIGLVI	TMPRSS11E	11	Q9UL52
CFWLWDAGTLKINPR	PHIP	296	Q8WWQ0
EIFPWALGKDWCLRV	SPDYC	131	Q5MJ68
RITPKDSRWVGAWWL	SLCO1B3	246	Q9NPD5
KWSLRWFLSPRWILQ	nan	66	Q6ZVQ6
LAKPDTSFWIKCRRW	nan	111	Q8IYB0
LPWALLINESKWDLW	VPS13B	2986	Q7Z7G8
PELWLLLWAAAWRLG	SLIT1	16	O75093
VALVVAPLCWKAGEW	TYSND1	276	Q2T9J0
WDDPWFSRLEVLGCK	ZNF606	166	Q8WXB4
EISLGPACWLWDFLR	NADSYN1	331	Q6IA69
EEAKVAFLKWICRWP	MYO7B	1991	Q6PIF6