Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhistone H3K14 acetyltransferase activity

BRPF3 BRD1 KAT6B

5.31e-069813GO:0036408
GeneOntologyMolecularFunctionhistone H3 acetyltransferase activity

BRPF3 BRD1 KAT6B

2.82e-0515813GO:0010484
GeneOntologyMolecularFunctionhistone modifying activity

USP49 BRPF3 SLK KDM2A PKN1 BRD1 KAT6B

4.03e-05229817GO:0140993
GeneOntologyMolecularFunctionpeptide-lysine-N-acetyltransferase activity

ESCO2 BRPF3 BRD1 KAT6B

7.32e-0555814GO:0061733
GeneOntologyMolecularFunctionpeptide N-acetyltransferase activity

ESCO2 BRPF3 BRD1 KAT6B

1.03e-0460814GO:0034212
GeneOntologyMolecularFunctionG-protein beta/gamma-subunit complex binding

GNA11 GNA12 GNAQ

1.39e-0425813GO:0031683
GeneOntologyMolecularFunctionalkylglycerophosphoethanolamine phosphodiesterase activity

GNA11 GNAQ

1.61e-045812GO:0047391
GeneOntologyMolecularFunctionN-acetyltransferase activity

ESCO2 BRPF3 BRD1 KAT6B

2.85e-0478814GO:0008080
GeneOntologyMolecularFunctioncysteine-type endopeptidase activity

CFLAR USP49 CASP9 CAPN5

4.14e-0486814GO:0004197
GeneOntologyMolecularFunctionN-acyltransferase activity

ESCO2 BRPF3 BRD1 KAT6B

7.90e-04102814GO:0016410
GeneOntologyMolecularFunctionacetyltransferase activity

ESCO2 BRPF3 BRD1 KAT6B

8.49e-04104814GO:0016407
GeneOntologyMolecularFunctionhistone H4K8 acetyltransferase activity

BRPF3 BRD1

8.73e-0411812GO:0043996
GeneOntologyMolecularFunctionhistone H4K5 acetyltransferase activity

BRPF3 BRD1

8.73e-0411812GO:0043995
GeneOntologyMolecularFunctionhistone H4K12 acetyltransferase activity

BRPF3 BRD1

1.04e-0312812GO:0043997
GeneOntologyMolecularFunctionhistone acetyltransferase activity

BRPF3 BRD1 KAT6B

1.16e-0351813GO:0004402
GeneOntologyMolecularFunctionG protein activity

GNA11 GNA12 GNAQ

1.78e-0359813GO:0003925
GeneOntologyCellularComponentMOZ/MORF histone acetyltransferase complex

BRPF3 BRD1 KAT6B

2.01e-067823GO:0070776
GeneOntologyCellularComponentH3 histone acetyltransferase complex

BRPF3 BRD1 KAT6B

3.21e-068823GO:0070775
GeneOntologyCellularComponentperikaryon

CACNA1A SEMA4F KCNK1 KNDC1 GRIK5 BRD1

2.46e-04223826GO:0043204
GeneOntologyCellularComponentheterotrimeric G-protein complex

GNA11 GNA12 GNAQ

3.48e-0435823GO:0005834
GeneOntologyCellularComponentGTPase complex

GNA11 GNA12 GNAQ

5.57e-0441823GO:1905360
GeneOntologyCellularComponentcentrosome

TUBGCP6 FRY KIF15 LRRC45 CCNP CC2D1A CEP295 CROCC MTUS2 CCDC85B

8.46e-047708210GO:0005813
HumanPhenoEnlarged labia minora

ESCO2 KAT6B

1.95e-052232HP:0008683
HumanPhenoMydriasis

CACNA1A GNA11 GNAQ

4.33e-0516233HP:0011499
HumanPhenoVitreous hemorrhage

GNA11 CAPN5 GNAQ

6.28e-0518233HP:0007902
HumanPhenoChoroidal melanoma

GNA11 GNAQ

1.93e-045232HP:0012054
HumanPhenoCiliary body melanoma

GNA11 GNAQ

1.93e-045232HP:0012055
HumanPhenoIris melanoma

GNA11 GNAQ

1.93e-045232HP:0011524
HumanPhenoAbnormal visual accommodation

GNA11 GNAQ

1.93e-045232HP:0030800
HumanPhenoInferior lens subluxation

GNA11 GNAQ

1.93e-045232HP:0008494
DomainG-alpha

GNA11 GNA12 GNAQ

4.71e-0516843PF00503
DomainGproteinA_insert

GNA11 GNA12 GNAQ

4.71e-0516843IPR011025
Domain-

GNA11 GNA12 GNAQ

4.71e-05168431.10.400.10
DomainG_alpha

GNA11 GNA12 GNAQ

4.71e-0516843SM00275
DomainZnf_PHD

BRPF3 PHF24 KDM2A BRD1 KAT6B

5.60e-0591845IPR001965
DomainGprotein_alpha_su

GNA11 GNA12 GNAQ

5.70e-0517843IPR001019
DomainZF_PHD_2

BRPF3 PHF24 KDM2A BRD1 KAT6B

6.88e-0595845PS50016
DomainZF_PHD_1

BRPF3 PHF24 KDM2A BRD1 KAT6B

7.23e-0596845PS01359
DomainGprotein_alpha_Q

GNA11 GNAQ

1.19e-044842IPR000654
DomainZinc_finger_PHD-type_CS

BRPF3 PHF24 KDM2A BRD1

2.09e-0465844IPR019786
DomainBromodomain_CS

BRPF3 ATAD2B BRD1

2.12e-0426843IPR018359
DomainZnf_PHD-finger

BRPF3 KDM2A BRD1 KAT6B

4.43e-0479844IPR019787
DomainZnf_FYVE_PHD

BRPF3 PHF24 KDM2A BRD1 KAT6B

5.29e-04147845IPR011011
DomainEPL1

BRPF3 BRD1

5.50e-048842PF10513
DomainEnhancer_polycomb-like_N

BRPF3 BRD1

5.50e-048842IPR019542
DomainBROMODOMAIN_1

BRPF3 ATAD2B BRD1

6.11e-0437843PS00633
DomainBromodomain

BRPF3 ATAD2B BRD1

6.61e-0438843PF00439
DomainPHD

BRPF3 KDM2A BRD1 KAT6B

6.95e-0489844SM00249
DomainBROMODOMAIN_2

BRPF3 ATAD2B BRD1

8.27e-0441843PS50014
DomainBROMO

BRPF3 ATAD2B BRD1

8.88e-0442843SM00297
DomainBromodomain

BRPF3 ATAD2B BRD1

8.88e-0442843IPR001487
Domain-

BRPF3 ATAD2B BRD1

8.88e-04428431.20.920.10
DomainCASc

CFLAR CASP9

1.51e-0313842SM00115
DomainPept_C14A

CFLAR CASP9

1.51e-0313842IPR015917
DomainPept_C14_p20

CFLAR CASP9

1.76e-0314842IPR001309
DomainCaspase-like_dom

CFLAR CASP9

1.76e-0314842IPR029030
DomainCASPASE_P20

CFLAR CASP9

1.76e-0314842PS50208
Domain-

CFLAR CASP9

1.76e-03148423.40.50.1460
DomainSemaphorin

SEMA6B SEMA4F

3.60e-0320842IPR027231
DomainPWWP

BRPF3 BRD1

3.60e-0320842SM00293
DomainC2

WWC2 CC2D1A PKN1 CAPN5

3.86e-03142844PS50004
Domain-

USP49 BRPF3 PHF24 KDM2A BRD1 KAT6B PDZRN3

4.09e-034498473.30.40.10
DomainEPHD

BRPF3 BRD1

4.36e-0322842PS51805
Domain-

UBR5 HERC6

4.36e-03228422.130.10.30
Domain-

WWC2 CC2D1A PKN1 CAPN5

4.47e-031488442.60.40.150
DomainZnf_RING/FYVE/PHD

USP49 BRPF3 PHF24 KDM2A BRD1 KAT6B PDZRN3

4.61e-03459847IPR013083
DomainPHD

BRPF3 BRD1 KAT6B

4.69e-0375843PF00628
DomainPWWP

BRPF3 BRD1

4.76e-0323842PF00855
DomainPWWP_dom

BRPF3 BRD1

4.76e-0323842IPR000313
DomainRCC1/BLIP-II

UBR5 HERC6

4.76e-0323842IPR009091
DomainPWWP

BRPF3 BRD1

5.17e-0324842PS50812
DomainC2_dom

WWC2 CC2D1A PKN1 CAPN5

6.41e-03164844IPR000008
PathwayPID_S1P_S1P2_PATHWAY

GNA11 GNA12 GNAQ CDH5

2.08e-0624554M268
PathwayBIOCARTA_MYOSIN_PATHWAY

GNA12 PKN1 GNAQ

9.07e-0611553M7014
PathwayPID_THROMBIN_PAR1_PATHWAY

GNA11 GNA12 PKN1 GNAQ

2.29e-0543554M238
PathwayPID_S1P_META_PATHWAY

GNA11 GNA12 GNAQ

7.11e-0521553M155
PathwayWP_PKCGAMMA_CALCIUM_SIGNALING_IN_ATAXIA

CACNA1A GNA11 GNAQ

8.21e-0522553M39795
PathwayKEGG_LONG_TERM_DEPRESSION

CACNA1A GNA11 GNA12 GNAQ

1.57e-0470554M8232
PathwayPID_S1P_S1P3_PATHWAY

GNA11 GNA12 GNAQ

1.91e-0429553M55
PathwayKEGG_MEDICUS_PATHOGEN_HCMV_UL33_TO_GNAQ_PLCB_G_CALCINEURIN_SIGNALING_PATHWAY

GNA11 GNAQ

2.22e-046552M47548
PathwayREACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS

GNA11 GNA12 GNAQ

2.57e-0432553MM15148
PathwayREACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS

GNA11 GNA12 GNAQ

2.57e-0432553M861
PathwayREACTOME_ACETYLCHOLINE_REGULATES_INSULIN_SECRETION

GNA11 GNAQ

4.12e-048552MM15032
PathwayREACTOME_FATTY_ACIDS_BOUND_TO_GPR40_FFAR1_REGULATE_INSULIN_SECRETION

GNA11 GNAQ

4.12e-048552M27356
PathwayREACTOME_FATTY_ACIDS_BOUND_TO_GPR40_FFAR1_REGULATE_INSULIN_SECRETION

GNA11 GNAQ

4.12e-048552MM15100
PathwayKEGG_MEDICUS_REFERENCE_LPA_GNAQ_11_RHOA_SIGNALING_PATHWAY

GNA11 GNAQ

5.29e-049552M47732
PathwayREACTOME_CHROMATIN_MODIFYING_ENZYMES

BRPF3 KDM2A BRD1 KAT6B BRMS1

5.86e-04175555MM14941
PathwayREACTOME_ACETYLCHOLINE_REGULATES_INSULIN_SECRETION

GNA11 GNAQ

6.59e-0410552M1825
PathwayREACTOME_HATS_ACETYLATE_HISTONES

BRPF3 BRD1 KAT6B

7.58e-0446553MM14935
PathwayREACTOME_FREE_FATTY_ACIDS_REGULATE_INSULIN_SECRETION

GNA11 GNAQ

8.04e-0411552M27317
PathwayREACTOME_FREE_FATTY_ACIDS_REGULATE_INSULIN_SECRETION

GNA11 GNAQ

8.04e-0411552MM15035
PathwayKEGG_MEDICUS_REFERENCE_KISS1_KISS1R_PLCB_PKC_SIGNALING_PATHWAY

GNA11 GNAQ

8.04e-0411552M47637
PathwayKEGG_MEDICUS_REFERENCE_TRH_TRHR_PLCB_PKC_SIGNALING_PATHWAY

GNA11 GNAQ

9.62e-0412552M47649
PathwayKEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION

CALD1 GNA11 GNA12 GNAQ

1.04e-03115554M9387
PathwayPID_TXA2PATHWAY

GNA11 GNA12 GNAQ

1.35e-0356553M99
PathwayPID_THROMBIN_PAR4_PATHWAY

GNA11 GNAQ

1.52e-0315552M138
PathwayREACTOME_REGULATION_OF_INSULIN_SECRETION

CACNA1A GNA11 GNAQ

1.72e-0361553MM15071
PathwayPID_ENDOTHELIN_PATHWAY

GNA11 GNA12 GNAQ

1.89e-0363553M8
Pubmed

Galpha12/13 is essential for directed cell migration and localized Rho-Dia1 function.

GNA11 GNA12 GNAQ

5.43e-08484316251183
Pubmed

Antagonistic regulation of neurite morphology through Gq/G11 and G12/G13.

GNA11 GNA12 GNAQ

5.43e-08484318854320
Pubmed

Anaphylactic shock depends on endothelial Gq/G11.

GNA11 GNA12 GNAQ

1.35e-07584319171764
Pubmed

G protein-dependent basal and evoked endothelial cell vWF secretion.

GNA11 GNA12 GNAQ

1.35e-07584324081657
Pubmed

G(13)-mediated signaling pathway is required for pressure overload-induced cardiac remodeling and heart failure.

GNA11 GNA12 GNAQ

1.35e-07584322972902
Pubmed

Procontractile G protein-mediated signaling pathways antagonistically regulate smooth muscle differentiation in vascular remodeling.

GNA11 GNA12 GNAQ

1.35e-07584323129751
Pubmed

Translating biased signaling in the ghrelin receptor system into differential in vivo functions.

GNA11 GNA12 GNAQ

1.35e-07584330301804
Pubmed

Myogenic vasoconstriction requires G12/G13 and LARG to maintain local and systemic vascular resistance.

GNA11 GNA12 GNAQ

1.35e-07584331549965
Pubmed

Loss of epithelial Gq and G11 signaling inhibits TGFβ production but promotes IL-33-mediated macrophage polarization and emphysema.

GNA11 GNA12 GNAQ

2.70e-07684327811142
Pubmed

G12-G13-LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension.

GNA11 GNA12 GNAQ

2.70e-07684318084302
Pubmed

Protein kinase C-related kinase and ROCK are required for thrombin-induced endothelial cell permeability downstream from Galpha12/13 and Galpha11/q.

GNA11 GNA12 PKN1

2.70e-07684318713748
Pubmed

Lysophospholipids control integrin-dependent adhesion in splenic B cells through G(i) and G(12)/G(13) family G-proteins but not through G(q)/G(11).

GNA11 GNA12 GNAQ

4.72e-07784317023430
Pubmed

Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes.

BRPF3 BRD1 KAT6B

4.72e-07784318794358
Pubmed

Analysis of G protein alpha subunit mRNA abundance in preimplantation mouse embryos using a rapid, quantitative RT-PCR approach.

GNA11 GNA12 GNAQ

1.61e-06108438588930
Pubmed

The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families.

GNA11 GNA12 GNAQ

1.61e-06108438552586
Pubmed

Knockout mouse models reveal the contributions of G protein subunits to complement C5a receptor-mediated chemotaxis.

GNA11 GNA12 GNAQ

2.21e-061184332332099
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

MYCL SEMA6B PHLDB3 SEMA4F EIF4ENIF1 SND1 SURF6 DEF6 SNX8 CC2D1A GNA12 PKN1 ELAC2

2.43e-061105841335748872
Pubmed

Age-dependent blood pressure elevation is due to increased vascular smooth muscle tone mediated by G-protein signalling.

GNA11 GNA12 GNAQ

3.82e-061384326531127
Pubmed

GNAQ and GNA11 mutations occur in 9.5% of mucosal melanoma and are associated with poor prognosis.

GNA11 GNAQ

5.76e-06284227498141
Pubmed

The Role of Mutation Rates of GNAQ or GNA11 in Cases of Uveal Melanoma in Japan.

GNA11 GNAQ

5.76e-06284228248732
Pubmed

Uveal Melanoma: GNAQ and GNA11 Mutations in a Greek Population.

GNA11 GNAQ

5.76e-06284228982892
Pubmed

Mutations in GNA11 in uveal melanoma.

GNA11 GNAQ

5.76e-06284221083380
Pubmed

Activation of Gq/11 in the mouse corpus luteum is required for parturition.

GNA11 GNAQ

5.76e-06284225495873
Pubmed

GNAQ and GNA11 mutations in uveal melanoma.

GNA11 GNAQ

5.76e-06284225304237
Pubmed

Epidermal loss of Gαq confers a migratory and differentiation defect in keratinocytes.

GNA11 GNAQ

5.76e-06284228301547
Pubmed

Forebrain-specific inactivation of Gq/G11 family G proteins results in age-dependent epilepsy and impaired endocannabinoid formation.

GNA11 GNAQ

5.76e-06284216847339
Pubmed

Uveal melanoma driver mutations in GNAQ/11 yield numerous changes in melanocyte biology.

GNA11 GNAQ

5.76e-06284229570931
Pubmed

Muscarinic inhibition of calcium current and M current in Galpha q-deficient mice.

GNA11 GNAQ

5.76e-06284210818132
Pubmed

Endothelial Gαq/11 is required for VEGF-induced vascular permeability and angiogenesis.

GNA11 GNAQ

5.76e-06284226272756
Pubmed

NK2 receptor-mediated detrusor muscle contraction involves Gq/11-dependent activation of voltage-dependent Ca2+ channels and the RhoA-Rho kinase pathway.

GNA11 GNAQ

5.76e-06284231461351
Pubmed

Ultradeep sequencing detects GNAQ and GNA11 mutations in cell-free DNA from plasma of patients with uveal melanoma.

GNA11 GNAQ

5.76e-06284223634288
Pubmed

Distribution of GNAQ and GNA11 Mutation Signatures in Uveal Melanoma Points to a Light Dependent Mutation Mechanism.

GNA11 GNAQ

5.76e-06284226368812
Pubmed

Postsynaptic mechanisms underlying responsiveness of amygdaloid neurons to cholecystokinin are mediated by a transient receptor potential-like current.

GNA11 GNAQ

5.76e-06284217482476
Pubmed

Molecular genetic testing of uveal melanoma from routinely processed and stained cytology specimens.

GNA11 GNAQ

5.76e-06284221945171
Pubmed

Combined PKC and MEK inhibition in uveal melanoma with GNAQ and GNA11 mutations.

GNA11 GNAQ

5.76e-06284224141786
Pubmed

Interaction of the G-protein G11alpha with receptors and phosphoinositidase C: the contribution of G-protein palmitoylation and membrane association.

GNA11 GNAQ

5.76e-0628429175863
Pubmed

The ethnic profile of patients with birthmarks reveals interaction of germline and postzygotic genetics.

GNA11 GNAQ

5.76e-06284228083870
Pubmed

Stretch regulates alveologenesis and homeostasis via mesenchymal Gαq/11-mediated TGFβ2 activation.

GNA11 GNAQ

5.76e-06284237102682
Pubmed

Gq/11-Dependent Changes in the Murine Ovarian Transcriptome at the End of Gestation.

GNA11 GNAQ

5.76e-06284226843449
Pubmed

Direct targeting of Gαq and Gα11 oncoproteins in cancer cells.

GNA11 GNAQ

5.76e-06284230890659
Pubmed

Ca2+ signalling in K562 human erythroleukaemia cells: effect of dimethyl sulphoxide and role of G-proteins in thrombin- and thromboxane A2-activated pathways.

GNA11 GNAQ

5.76e-0628427492305
Pubmed

Reduced trabecular bone mass and strength in mice overexpressing Gα11 protein in cells of the osteoblast lineage.

GNA11 GNAQ

5.76e-06284224308950
Pubmed

Gαq and Gα11 contribute to the maintenance of cellular electrophysiology and Ca2+ handling in ventricular cardiomyocytes.

GNA11 GNAQ

5.76e-06284222562663
Pubmed

Functional specificity of G alpha q and G alpha 11 in the cholinergic and glutamatergic modulation of potassium currents and excitability in hippocampal neurons.

GNA11 GNAQ

5.76e-06284211826096
Pubmed

Blue nevi and variants: an update.

GNA11 GNAQ

5.76e-06284221366456
Pubmed

In uveal melanoma Gα-protein GNA11 mutations convey a shorter disease-specific survival and are more strongly associated with loss of BAP1 and chromosomal alterations than Gα-protein GNAQ mutations.

GNA11 GNAQ

5.76e-06284235580369
Pubmed

Gonadotropin and gonadal steroid release in response to a gonadotropin-releasing hormone agonist in Gqalpha and G11alpha knockout mice.

GNA11 GNAQ

5.76e-0628429607776
Pubmed

Reverse Phenotyping in Patients with Skin Capillary Malformations and Mosaic GNAQ or GNA11 Mutations Defines a Clinical Spectrum with Genotype-Phenotype Correlation.

GNA11 GNAQ

5.76e-06284231726051
Pubmed

Papillary Hemangioma Harbors Somatic GNA11 and GNAQ Mutations.

GNA11 GNAQ

5.76e-06284237750536
Pubmed

G(alpha)q-deficient mice lack metabotropic glutamate receptor-dependent long-term depression but show normal long-term potentiation in the hippocampal CA1 region.

GNA11 GNAQ

5.76e-06284211438569
Pubmed

GNAQ/GNA11 Mosaicism Is Associated with Abnormal Serum Calcium Indices and Microvascular Neurocalcification.

GNA11 GNAQ

5.76e-06284237802294
Pubmed

Mosaic Activating Mutations in GNA11 and GNAQ Are Associated with Phakomatosis Pigmentovascularis and Extensive Dermal Melanocytosis.

GNA11 GNAQ

5.76e-06284226778290
Pubmed

Distinct profiles of functional discrimination among G proteins determine the actions of G protein-coupled receptors.

GNA11 GNAQ

5.76e-06284226628681
Pubmed

Skeletal Muscle-Specific Activation of Gq Signaling Maintains Glucose Homeostasis.

GNA11 GNAQ

5.76e-06284230936140
Pubmed

The time-course of agonist-induced solubilization of trimeric G(q)alpha/G(11)alpha proteins resolved by two-dimensional electrophoresis.

GNA11 GNAQ

5.76e-06284217552882
Pubmed

Patient survival in uveal melanoma is not affected by oncogenic mutations in GNAQ and GNA11.

GNA11 GNAQ

5.76e-06284223778528
Pubmed

Distinct roles for Ste20-like kinase SLK in muscle function and regeneration.

SLK MYOG

5.76e-06284223815977
Pubmed

High throughput mass spectrometry-based mutation profiling of primary uveal melanoma.

GNA11 GNAQ

5.76e-06284222977135
Pubmed

An experimental strategy to probe Gq contribution to signal transduction in living cells.

GNA11 GNAQ

5.76e-06284233639168
Pubmed

GNAQ and GNA11 mutant nonuveal melanoma: a subtype distinct from both cutaneous and uveal melanoma.

GNA11 GNAQ

5.76e-06284232064597
Pubmed

Mutational analysis of GNAQ and GNA11 to aid therapy management of a choroidal melanoma metastatic to the contralateral orbit.

GNA11 GNAQ

5.76e-06284223572068
Pubmed

Heterogeneity in Mitogen-Activated Protein Kinase (MAPK) Pathway Activation in Uveal Melanoma With Somatic GNAQ and GNA11 Mutations.

GNA11 GNAQ

5.76e-06284231173078
Pubmed

Low mutational burden of eight genes involved in the MAPK/ERK, PI3K/AKT, and GNAQ/11 pathways in female genital tract primary melanomas.

GNA11 GNAQ

5.76e-06284225695059
Pubmed

Frequent and Yet Unreported GNAQ and GNA11 Mutations are Found in Uveal Melanomas.

GNA11 GNAQ

5.76e-06284229209985
Pubmed

Group I metabotropic glutamate receptor signaling via Galpha q/Galpha 11 secures the induction of long-term potentiation in the hippocampal area CA1.

GNA11 GNAQ

5.76e-06284212351712
Pubmed

Cardiac remodeling in Gαq and Gα11 knockout mice.

GNA11 GNAQ

5.76e-06284226476043
Pubmed

Early-onset hypertension associated with extensive cutaneous capillary malformations harboring postzygotic variants in GNAQ and GNA11.

GNA11 GNAQ

5.76e-06284236440997
Pubmed

Loss of Gq/11 family G proteins in the nervous system causes pituitary somatotroph hypoplasia and dwarfism in mice.

GNA11 GNAQ

5.76e-06284215713647
Pubmed

Distinct roles of Galpha(q) and Galpha11 for Purkinje cell signaling and motor behavior.

GNA11 GNAQ

5.76e-06284215175381
Pubmed

GNAQ and GNA11 mutations in melanocytomas of the central nervous system.

GNA11 GNAQ

5.76e-06284222307269
Pubmed

Oncogenic GNAQ and GNA11 mutations in uveal melanoma in Chinese.

GNA11 GNAQ

5.76e-06284225280020
Pubmed

Mechanism of GTP hydrolysis by G-protein alpha subunits.

GNA11 GNA12 GNAQ

6.06e-06158437937899
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

CACNA1A SLK CALD1 SND1 AMOT SPTA1 KNDC1 GNAQ MAP7 CROCC CCDC177 MTUS2 PPP1R12C RPL19

8.01e-061431841437142655
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

TUBGCP6 BRPF3 EIF4ENIF1 MCM8 UBR5 SURF6 PNMA2 CEP295 MAP7 BRD1 KAT6B PDZRN3

1.51e-051116841231753913
Pubmed

Frequent GNAQ, GNA11, and EIF1AX Mutations in Iris Melanoma.

GNA11 GNAQ

1.73e-05384228700778
Pubmed

Dissecting Gq/11-Mediated Plasma Membrane Translocation of Sphingosine Kinase-1.

GNA11 GNAQ

1.73e-05384233003441
Pubmed

P2Y₂ and Gq/G₁₁ control blood pressure by mediating endothelial mechanotransduction.

GNA11 GNAQ

1.73e-05384226168216
Pubmed

G alpha12 interaction with alphaSNAP induces VE-cadherin localization at endothelial junctions and regulates barrier function.

GNA12 CDH5

1.73e-05384215980433
Pubmed

The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling.

GNA11 GNAQ

1.73e-05384210446129
Pubmed

Specificity of G alpha q and G alpha 11 gene expression in platelets and erythrocytes. Expressions of cellular differentiation and species differences.

GNA11 GNAQ

1.73e-0538428836152
Pubmed

Gqα/G11α deficiency in dorsomedial hypothalamus leads to obesity resulting from decreased energy expenditure and impaired sympathetic nerve activity.

GNA11 GNAQ

1.73e-05384233166186
Pubmed

Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Galphaq/Galpha11 in cardiomyocytes.

GNA11 GNAQ

1.73e-05384211689889
Pubmed

Diabetes-related defects in sarcoplasmic Ca2+ release are prevented by inactivation of G(alpha)11 and G(alpha)q in murine cardiomyocytes.

GNA11 GNAQ

1.73e-05384220372981
Pubmed

Endocannabinoid-mediated modulation of Gq/11 protein-coupled receptor signaling-induced vasoconstriction and hypertension.

GNA11 GNAQ

1.73e-05384225595485
Pubmed

Expression of GTP-binding protein alpha subunits in human thymocytes.

GNA12 GNAQ

1.73e-0538427791744
Pubmed

The orphan receptor GPR139 signals via Gq/11 to oppose opioid effects.

GNA11 GNAQ

1.73e-05384232576659
Pubmed

Thyrocyte-specific Gq/G11 deficiency impairs thyroid function and prevents goiter development.

GNA11 GNAQ

1.73e-05384217694176
Pubmed

Identification of HRAS mutations and absence of GNAQ or GNA11 mutations in deep penetrating nevi.

GNA11 GNAQ

1.73e-05384223599145
Pubmed

Heterotrimeric G proteins of the Gq/11 family are crucial for the induction of maternal behavior in mice.

GNA11 GNAQ

1.73e-05384215340067
Pubmed

Galphao2 regulates vesicular glutamate transporter activity by changing its chloride dependence.

GNA11 GNAQ

1.73e-05384215872115
Pubmed

GNA11 and N-RAS mutations: alternatives for MAPK pathway activating GNAQ mutations in primary melanocytic tumours of the central nervous system.

GNA11 GNAQ

1.73e-05384222758774
Pubmed

Regulation of the epithelial Na+ channel by the RH domain of G protein-coupled receptor kinase, GRK2, and Galphaq/11.

GNA11 GNAQ

1.73e-05384221464134
Pubmed

G protein diversity: a distinct class of alpha subunits is present in vertebrates and invertebrates.

GNA11 GNAQ

1.73e-0538422123549
Pubmed

Balance of Go1α and Go2α expression regulates motor function via the striatal dopaminergic system.

GNA11 GNA12

1.73e-05384229747224
Pubmed

CXCL2/CXCR2 axis induces cancer stem cell characteristics in CPT-11-resistant LoVo colon cancer cells via Gαi-2 and Gαq/11.

GNA11 GNAQ

1.73e-05384230552676
Pubmed

Intraocular Metastasis in Unilateral Multifocal Uveal Melanoma Without Melanocytosis or Germline BAP1 Mutations.

GNA11 GNAQ

1.73e-05384231580399
Pubmed

G alpha(q) signal in osteoblasts is inhibitory to the osteoanabolic action of parathyroid hormone.

GNA11 GNAQ

1.73e-05384221345793
Pubmed

Normal hematopoiesis and inflammatory responses despite discrete signaling defects in Galpha15 knockout mice.

GNA11 GNAQ

1.73e-05384210629036
Pubmed

Parathyroid-specific double knockout of Gq and G11 alpha-subunits leads to a phenotype resembling germline knockout of the extracellular Ca2+ -sensing receptor.

GNA11 GNAQ

1.73e-05384216988000
Pubmed

Prognostic impact of chromosomal aberrations and GNAQ, GNA11 and BAP1 mutations in uveal melanoma.

GNA11 GNAQ

1.73e-05384228444874
GeneFamilyPHD finger proteins

BRPF3 PHF24 KDM2A BRD1 KAT6B

4.38e-069049588
GeneFamilyImmunoglobulin like domain containing|Semaphorins

SEMA6B SEMA4F

1.33e-0320492736
GeneFamilyPWWP domain containing

BRPF3 BRD1

1.61e-03224921147
CoexpressionOCONNOR_PBMC_MENVEO_ACWYVAX_AGE_30_70YO_7DY_AFTER_SECOND_DOSE_VS_7DY_AFTER_FIRST_DOSE_UP

SND1 MRPS16 KDM2A PKN1 CROCC KAT6B BRMS1

4.20e-07146837M41190
CoexpressionGSE6259_FLT3L_INDUCED_DEC205_POS_DC_VS_BCELL_DN

ESCO2 MYCL SLK KIF15 SND1 WDFY4 ITM2A

1.17e-06170837M6762
CoexpressionGABRIELY_MIR21_TARGETS

WWC2 CALD1 APOLD1 UBR5 TENT5A ATAD2B GNAQ

3.74e-05289837M2196
CoexpressionGSE360_L_DONOVANI_VS_M_TUBERCULOSIS_DC_UP

ARHGEF18 CASP9 GNAQ CDH5 SLC4A3 CCDC85B

4.12e-05199836M5205
ToppCellmetastatic_Brain-Endothelial_cells-Stalk-like_ECs|metastatic_Brain / Location, Cell class and cell subclass

SEMA6B FRY APOLD1 AMOT CCNP CDH5 PDZRN3

6.15e-08185847ad52970e88e8947ef256095bd4b40229b912d58a
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD4_T-CD4_T_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SEMA4F KIF15 ARHGEF18 DRC1 CROCC PIF1

7.65e-07167846754e6412d3b9cc0b126e59593df2f5956b4712ef
ToppCellPND01-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ESCO2 OGFRL1 KIF15 MCM8 WDFY4 SYCE1L

7.92e-0716884652fd65024af8683db11d931f7563cbe8eb815d1c
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-B_cells-STAT1+_Naive_B|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MXD3 APOLD1 TCL1A WDFY4 PIF1 RPL19

7.92e-07168846ba127d97697202a8558a0d50bcdafa30b0509de1
ToppCell5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MXD3 SEMA4F KIF15 APOLD1 CDH5 PIF1

1.11e-06178846ea10117026021c959ffc871fc377cdb3e161d264
ToppCelldroplet-Spleen-SPLEEN-1m-Lymphocytic-immature_NKT_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ESCO2 TYRO3 MXD3 KIF15 ITM2A PIF1

1.39e-06185846736bf89a7a1a840ab6920060f2d98598332065a0
ToppCellcontrol-pDC|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

MYCL TCL1A KCNK1 WDFY4 SLC4A3 CUEDC1

1.48e-06187846c78aee98b32719aa45811b620fc97be1ecf5fd53
ToppCell343B-Lymphocytic-ILC-ILC-1|343B / Donor, Lineage, Cell class and subclass (all cells)

ZNF821 CASP9 CEP295 BRD1 ELAC2 ATG16L2

1.52e-061888468f6b45ad82bde65e044d17f0edbc3db90d457915
ToppCellpdx-Tumor_cells-T1|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

ESCO2 KIF15 MCM8 APOLD1 CEP295 PIF1

1.62e-06190846d06ee5f89f1cec8db6897fe3b2a890a07cd3697b
ToppCellhuman_hepatoblastoma-Tumor_cells-T1|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

ESCO2 KIF15 MCM8 APOLD1 CEP295 PIF1

1.77e-061938464b9fa2a4424f8abe63fa7bee78db93dda04ab15f
ToppCellPBMC-Control-Myeloid-cDC-cDC-cDC_3|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MYCL OGFRL1 GNAQ MAP7 WDFY4 SLC4A3

1.83e-06194846b16ed97eb6b7b7a220e943474c0d85c141b6e3a5
ToppCellPBMC-Control-Myeloid-cDC-cDC-cDC_3|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

MYCL OGFRL1 GNAQ MAP7 WDFY4 SLC4A3

1.83e-061948462210f0755882d8f04edb4c109fb17c3f9149f6f7
ToppCellCOVID-19-T_cells-Cycling_NK/T_cells|COVID-19 / group, cell type (main and fine annotations)

ESCO2 KIF15 MCM8 APOLD1 SPTA1 PIF1

1.88e-06195846764ed100c28d9bc93ee5ecabc5291c8f184d78da
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-G|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SEMA6B FRY APOLD1 CDH5 ITM2A CCDC85B

2.00e-06197846a312d9cf4ced949307eb9620be4eed926300b892
ToppCellmild-pDC|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

MYCL TCL1A WDFY4 SLC4A3 PDZRN3 CUEDC1

2.00e-0619784615230a54fa5903dd728de1a0ad633bd2d2c7a04d
ToppCellsevere-pDC|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

MYCL TCL1A KCNK1 WDFY4 SLC4A3 CUEDC1

2.06e-0619884622da4a29b9ff8b94d98bc69b4632a2a58d5dd9e6
ToppCellHematolymphoid-Endothelial-NOSTRIN|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

FRY CALD1 APOLD1 CDH5 ITM2A PDZRN3

2.18e-06200846032df80aa5c40991e1c1e80f9d8da106e6aeaee2
ToppCellHematolymphoid-Endothelial-NOSTRIN---|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

FRY CALD1 APOLD1 CDH5 ITM2A PDZRN3

2.18e-0620084668fce28690246895fd33354b30960ebcc31aa4cc
ToppCellHematolymphoid-Endothelial-NOSTRIN-|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

FRY CALD1 APOLD1 CDH5 ITM2A PDZRN3

2.18e-06200846376b19ab5a7cd2c85f726d8ba41337d4525863e5
ToppCellHematolymphoid-Endothelial-NOSTRIN--|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

FRY CALD1 APOLD1 CDH5 ITM2A PDZRN3

2.18e-062008467fa54370221ed61bac0e09e6bcf1f3dff202a846
ToppCellHematolymphoid-Endothelial-NOSTRIN----L2-6|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

FRY CALD1 APOLD1 CDH5 ITM2A PDZRN3

2.18e-06200846878bbbe32e3602723aa14ef32877ab2453b8c6e5
ToppCellHematolymphoid-Endothelial|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

FRY CALD1 APOLD1 CDH5 ITM2A PDZRN3

2.18e-062008467136936d05ab344a560cf159684c881063b5430d
ToppCell3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic-EC_venous_systemic_L.2.2.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SEMA6B CALD1 APOLD1 CDH5 ITM2A CCDC85B

2.18e-06200846310c75e13be9194312a8b686804edcf13d44caf5
ToppCellEndothelial-H_(cycle)|World / shred on cell class and cell subclass (v4)

MXD3 KIF15 PABPC5 CDH5 PIF1

5.36e-061338458e3005114761feee028c496cc739e607b35d7831
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma|TCGA-Brain / Sample_Type by Project: Shred V9

NFE2L1 AMOT DEF6 CROCC WDFY4

1.40e-05162845810881210e015c788814e4fe8d7a24c929cf2621
ToppCellChildren_(3_yrs)-Immune-dendritic_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

MYCL TCL1A WDFY4 SLC4A3 MTUS2

1.40e-0516284586a0b9dabd150dc993bfc0f3344804de7f8e4042
ToppCelldroplet-Heart-nan-18m-Hematologic-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ESCO2 MXD3 SEMA4F KIF15 WDFY4

1.40e-051628457f425a3983325a5a3ea33f812b15aa010cc55de0
ToppCellLPS-antiTNF-Epithelial_airway-Mes-Epi-like|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ESCO2 MXD3 KIF15 KCNK1 PIF1

1.48e-051648454307b002fb41ddfc7ab8a6bca66a60942c250052
ToppCellLPS-antiTNF-Epithelial_airway-Mes-Epi-like-Airway|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ESCO2 MXD3 KIF15 KCNK1 PIF1

1.48e-051648451d84aa5b925f502ee9c5fa39714490f613a58028
ToppCellBronchial_Biopsy-Immune-T_and_NK|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X

FRY CALD1 APOLD1 CDH5 PIF1

1.66e-05168845435b2f238fbb3f50427e8cdecf2220615015153c
ToppCelldroplet-Lung-nan-18m-Myeloid-dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ESCO2 MYCL MXD3 PHF24 WDFY4

1.66e-0516884596f7411474edd673b8d3ee6b8a8bb185c246daaf
ToppCellEndothelial-B-Donor_08|World / lung cells shred on cell class, cell subclass, sample id

CALD1 APOLD1 PHF24 PABPC5 CDH5

1.81e-0517184507ff7059071da83da1d8f266a586573920d75b58
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ESCO2 KIF15 APOLD1 WDFY4 PIF1

1.81e-0517184555c7bf7211587fa08df13c0a4ff5b78a85d5439e
ToppCellChildren_(3_yrs)-Immune-dendritic_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

MYCL TCL1A WDFY4 SLC4A3 MTUS2

1.81e-051718456a5ac0f56bd7b4543be103100fb735ca6bc5b8bf
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ESCO2 MXD3 KIF15 APOLD1 PIF1

1.97e-05174845c26eac176e9b0cba385630fdc60e0314a4e4caac
ToppCellPND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ESCO2 MXD3 KIF15 GNA12 PIF1

1.97e-0517484572df66319f6efbd88ecf439013d97409fbf3cb52
ToppCellPND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ESCO2 MXD3 KIF15 GNA12 PIF1

1.97e-05174845c6087fd0e036ec7f40f0f8f17d1f6ce13ddb5235
ToppCelldroplet-Lung-18m-Hematologic-myeloid-myeloid_dendritic_cell-proliferating_dendritic|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ESCO2 MYCL MXD3 KIF15 WDFY4

2.02e-05175845a6913f992a1ea20b43e5adeca3ede3a6fda820ad
ToppCellBAL-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ESCO2 MXD3 KIF15 APOLD1 PIF1

2.02e-05175845553e68e8b439a2293efb969e1e2aa017ceb80daf
ToppCellBAL-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

ESCO2 MXD3 KIF15 APOLD1 PIF1

2.02e-0517584516d4e97271df1db9a0d167fc82a90d84d20dd1f2
ToppCellBAL-Control-Lymphocyte-T/NK-Other_T|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

ESCO2 MXD3 KIF15 APOLD1 PIF1

2.02e-05175845289d2aa7164bc02b1876b99f2fb67baa8e030c4e
ToppCelldroplet-Lung-3m-Hematologic-myeloid-myeloid_dendritic_cell-proliferating_dendritic|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ESCO2 MYCL KIF15 PHF24 WDFY4

2.08e-05176845581045e61cdcdfa85701343d1a7c0a72a36606a7
ToppCelldroplet-Lung-18m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell-proliferating_NK|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ESCO2 TYRO3 MXD3 KIF15 PIF1

2.08e-05176845b17317ac41d3215db55a38cbd3366c0947f7a2a3
ToppCellBAL-Severe-cDC_3|Severe / Compartment, Disease Groups and Clusters

MYCL TYRO3 MXD3 AMOT DEF6

2.14e-05177845939487a05311b66edfc3f44a7955fbf25266d6bf
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Dendritic-plasmacytoid_dendritic_cell|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TCL1A KCNK1 WDFY4 SLC4A3 CUEDC1

2.26e-05179845124da6f882968dc0d05f3edd8f3b4d61617cc214
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Dendritic-plasmacytoid_dendritic_cell-DC_c4-LILRA4|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TCL1A KCNK1 WDFY4 SLC4A3 CUEDC1

2.26e-05179845edc5ef693dc4e7ea70717b77fb908fc784dce3a2
ToppCellPND01-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ESCO2 MXD3 KIF15 CDH5 PIF1

2.32e-05180845b35a8c6169f4b548b912af005e92ae7c6596f376
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c11-MKI67-FOS|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

KIF15 LRRC45 APOLD1 MRPS16 ITM2A

2.38e-051818456873c1138b28c130637d06b64981ad11c262e85f
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling-Cycling_Connecting_Tubule_Cell_G2M|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ESCO2 MXD3 KIF15 APOLD1 PIF1

2.44e-05182845336cd05e46a741185ce3c59ee67a4b07fa6a5101
ToppCellPND14-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ESCO2 MXD3 KIF15 MCM8 PIF1

2.44e-0518284521dcab170ffeef89faa9fee5008568cb6e15c694
ToppCellfacs-Skin-Skin_Anagen-18m-Epithelial-keratinocyte_stem_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ESCO2 MXD3 KIF15 CROCC PIF1

2.44e-051828450fc45214f0b0766f69be6eff69cc4bec574023aa
ToppCellControl-T/NK-proliferating_T/NK|Control / Disease group,lineage and cell class （2021.01.30）

ESCO2 MXD3 KIF15 APOLD1 PIF1

2.51e-05183845e740f05536d1e4b2512811771928eb65f6696409
ToppCellDividing_Macrophages-IPF_01|World / lung cells shred on cell class, cell subclass, sample id

ESCO2 MXD3 KIF15 MCM8 PIF1

2.57e-05184845f15ce786d25c6546804a6d1efcc2ad645f2ef54e
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ESCO2 MXD3 KIF15 PABPC5 PIF1

2.57e-05184845d1e0e3b0eed2db8a5b7e3d6f81294667e4ba64e5
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA6B APOLD1 CDH5 CCDC85B RPL19

2.57e-05184845a12a6a481e78adc62da1904431f62b119f70b15f
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ESCO2 MXD3 KIF15 APOLD1 PIF1

2.64e-0518584530e041d6f6e310d64809e9d6d93cd30052972f3b
ToppCellControl-Myeloid-cDC1|World / Disease state, Lineage and Cell class

MYCL PHLDB3 SNX8 WDFY4 MTUS2

2.71e-051868453de803dee3ef10eb85a2b47d3f93385214e5b0ff
ToppCellIIH-pDC-|IIH / Condition, Cell_class and T cell subcluster

MYCL TCL1A KCNK1 SLC4A3 CUEDC1

2.78e-05187845ad87b146ea8dd9f695e722f8f0e8e1057c7f3167
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m-Epithelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ESCO2 MYCL MXD3 KIF15 PIF1

2.78e-051878454d12c70c8ed922fbc8f7b139145611203735cab4
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m-Epithelial-neuronal_stem_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ESCO2 MYCL MXD3 KIF15 PIF1

2.78e-05187845e46b49b4053d2d0f3e1d2bcdc380f7f8733cbe07
ToppCellIIH-pDC|IIH / Condition, Cell_class and T cell subcluster

MYCL TCL1A KCNK1 SLC4A3 CUEDC1

2.78e-051878455e59e9153a18bcfb5c8dc94599080216661de7ce
ToppCellControl-Lymphoid-B|Lymphoid / Disease state, Lineage and Cell class

TCL1A SNX8 ARHGEF18 GNA12 WDFY4

2.78e-051878454e64be635f445276e71f2937f33f041c3a4204ab
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ESCO2 MXD3 KIF15 APOLD1 PIF1

2.78e-051878459351fa87b69a951af85b10bf91fe9b1cce8c0517
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m-Epithelial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ESCO2 MYCL MXD3 KIF15 PIF1

2.78e-05187845e851ee46a6b4068a7bd7602ee183c0ace50ee4dd
ToppCellIPF-Lymphoid-B|Lymphoid / Disease state, Lineage and Cell class

TCL1A SNX8 ARHGEF18 GNA12 WDFY4

2.78e-05187845af1327559f7e01bec070881cae52834917c3da65
ToppCell343B-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-|343B / Donor, Lineage, Cell class and subclass (all cells)

TYRO3 FRY CALD1 CDH5 ITM2A

2.85e-05188845fe7143c36e4a883745862d3c3147cf751b440e46
ToppCell343B-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)|343B / Donor, Lineage, Cell class and subclass (all cells)

TYRO3 FRY CALD1 CDH5 ITM2A

2.85e-05188845cbf32b675a7cd0c808d5c9c22dfa7fa79fbe2437
ToppCellLAM-Endothelial-VasEndo-1|LAM / Condition, Lineage and Cell class

FRY CALD1 CDH5 ITM2A CCDC85B

2.93e-05189845454e64b1ee93edebbc1576fbf7c3a6db332fa927
ToppCellMS-pDC-|MS / Condition, Cell_class and T cell subcluster

MYCL TCL1A KCNK1 SLC4A3 CUEDC1

3.00e-05190845f56ec302d556ace4f7609017a35c311cf43aa8a5
ToppCell3'_v3-bone_marrow-Myeloid_Dendritic|bone_marrow / Manually curated celltypes from each tissue

MYCL KCNK1 WDFY4 SLC4A3 CUEDC1

3.00e-051908456892c603037b61ef88d6ca01b7592dc0d347d63b
ToppCellMS-pDC|MS / Condition, Cell_class and T cell subcluster

MYCL TCL1A KCNK1 SLC4A3 CUEDC1

3.00e-05190845f41d7ab7d7fbcd73fddb6c3533c6a3e642e3d07f
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-Proliferating_T_cell-proliferating_T|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ESCO2 MXD3 KIF15 MCM8 PIF1

3.08e-0519184515dbc5a03bfab8931c0fd385b0f25874736ae874
ToppCellPCW_10-12-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

MXD3 KIF15 KCNK1 MAP7 PIF1

3.08e-0519184539220f4a345e328f7fa4fd462a0abeea821b3e02
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-Proliferating_T_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ESCO2 MXD3 KIF15 MCM8 PIF1

3.08e-0519184545c15f5ce4a207ac944bed65d45f06c1657d1a6d
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_cycling-mes_proliferating2_(11)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

ESCO2 MXD3 KIF15 APOLD1 PIF1

3.08e-051918450ba5b112a82e489f5a21966f78a403a7436ce73b
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_cycling-mes_proliferating2_(11)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ESCO2 MXD3 KIF15 APOLD1 PIF1

3.16e-0519284527723f4e320e49d4a3daafa2d8d3946ff79fab64
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_cycling-mes_proliferating2_(11)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ESCO2 MXD3 KIF15 APOLD1 PIF1

3.16e-051928450a54c79dcfdeb99e3b512d42b22359618cfd17e9
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_cycling-mes_proliferating2_(11)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ESCO2 MXD3 KIF15 APOLD1 PIF1

3.16e-05192845026f3e38970bea1e6e8d76a4e2becdfb8484b2ff
ToppCell15-Trachea-Epithelial-Intermediate_ciliated|Trachea / Age, Tissue, Lineage and Cell class

MYCL CFAP73 KNDC1 CAPN5 CUEDC1

3.16e-051928459cbe961a800c981cdc742a47ed18e9c8eb6430bd
ToppCellPND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ESCO2 MXD3 CALD1 KIF15 PIF1

3.23e-05193845a332dfdcc48c405020014e644aa4d14fda98cc86
ToppCellcontrol-pDC|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TCL1A KCNK1 WDFY4 SLC4A3 CUEDC1

3.23e-0519384530a6559c9a9e8941861cb259b4836acccc427e68
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ESCO2 MXD3 KIF15 APOLD1 PIF1

3.32e-051948451a2090e997c70433d07f56bf7cb0a50c4151118c
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_cycling-mes_proliferating3_(7)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ESCO2 MXD3 KIF15 MCM8 APOLD1

3.32e-05194845f9070035553bc68106a9e0bdf4b507715a138aba
ToppCellE15.5-Mesenchymal-developing_mesenchymal_cell|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ESCO2 MXD3 CALD1 KIF15 ITM2A

3.32e-05194845d840c1949c328779426c9172e02da09e968f0567
ToppCell3'-Child09-12-SmallIntestine-Hematopoietic-B_cells-Cycling_plasma_cell|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MXD3 KIF15 APOLD1 TCL1A PIF1

3.32e-0519484506b8dc2e46f833707d5b68b324b4ff6c4d0dccf9
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ESCO2 MXD3 KIF15 CDH5 PIF1

3.32e-051948453a49c7c86036e09a8cd0114988380d04ad1a26fb
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ESCO2 MXD3 KIF15 APOLD1 PIF1

3.40e-0519584575759fd7f925725f0ecd07214afcca5aa2158f9e
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ESCO2 MXD3 KIF15 CDH5 PIF1

3.40e-051958455790b47b0e028e49b99bda8d6d9e80ac79208cdf
ToppCellEndothelial|World / shred by cell class for bronchial biopsy

SEMA6B FRY CDH5 ITM2A CCDC85B

3.40e-05195845f0e46e859f7a9bdead3203889f7e20fa21f76ff0
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ESCO2 MXD3 KIF15 CDH5 PIF1

3.40e-05195845a838bddeed487154791b69d27a68673783ff63c0
ToppCellBAL-Control-Myeloid-Myeloid-proliferating_Myeloid_cells|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

ESCO2 MXD3 KIF15 APOLD1 PIF1

3.48e-051968456d80e23f6a1725a3f5ea7263233c55c2ea56f977
ToppCellBAL-Control-Myeloid-Myeloid|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ESCO2 MXD3 KIF15 APOLD1 PIF1

3.48e-05196845bf1d3fae8c01bb3d17c2dafad92b94937c663acd
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ESCO2 MXD3 KIF15 CDH5 PIF1

3.48e-0519684520383d576708b7e4bfce3e9fe40548cce496e3cb
ToppCelldistal-Hematologic-Plasmacytoid_Dendritic-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MYCL EIF4ENIF1 TCL1A WDFY4 SLC4A3

3.48e-05196845170629b9ae82e9a911b93e8739dcd38176fbecb4
ToppCellBAL-Control-Myeloid-Myeloid-proliferating_Myeloid_cells-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ESCO2 MXD3 KIF15 APOLD1 PIF1

3.48e-051968453dd7ed1dfac8d90c8a44f0ae00128bb46d9ef496
ToppCellBAL-Control-Myeloid-Myeloid-proliferating_Myeloid_cells-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ESCO2 MXD3 KIF15 APOLD1 PIF1

3.48e-051968454f649e3bfd21f21682678828673843a7d51c4ff2
ToppCellBAL-Control-Myeloid-Myeloid|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

ESCO2 MXD3 KIF15 APOLD1 PIF1

3.48e-05196845799c290fb3dfacb666dd0dc3c43ec8a86b697ec7
ToppCellBAL-Control-Myeloid-Myeloid-proliferating_Myeloid_cells|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ESCO2 MXD3 KIF15 APOLD1 PIF1

3.48e-051968450c003a767c3b58605099dab64b9df0d8e5d8bc4b
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ESCO2 MXD3 KIF15 CDH5 PIF1

3.48e-051968450644bd14a944b9c9759a295dfdd5e67a4775f20a
ToppCellmild-pDC|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

MYCL WDFY4 SLC4A3 PDZRN3 CUEDC1

3.57e-051978450cb00daa6943f7a7fb34a8fdf51188646af65686
Drugsalmeterol xinafoate

GNA11 GNA12 GNAQ CDH5

1.38e-0623834CID000056801
DiseasePhakomatosis cesioflammea

GNA11 GNAQ

7.44e-062812C3838883
DiseaseCongenital hemangioma

GNA11 GNAQ

7.44e-062812C0235753
DiseasePort-wine stain with oculocutaneous melanosis

GNA11 GNAQ

7.44e-062812C1274879
DiseaseMalignant melanoma of iris

GNA11 GNAQ

7.40e-055812C0346373
DiseaseMalignant melanoma of choroid

GNA11 GNAQ

7.40e-055812C0346388
Diseaselymphocyte percentage of leukocytes

MXD3 APOLD1 UBR5 HS6ST1 TENT5A SPTA1 ARHGEF18 GNAQ CROCC

8.74e-05665819EFO_0007993
DiseaseUveal melanoma

GNA11 GNAQ

2.06e-048812C0220633
Diseaseresponse to triptolide, cytotoxicity measurement

CFLAR MTUS2

8.71e-0416812EFO_0006952, EFO_0007662
Diseaselung non-small cell carcinoma (is_marker_for)

UBR5 CASP9 KDM2A GNAQ

1.23e-03169814DOID:3908 (is_marker_for)
DiseaseOvarian Failure, Premature

EIF4ENIF1 MCM8

1.51e-0321812C0085215
Diseasecreatinine measurement

MXD3 FRY SND1 NFE2L1 CCNP ARHGEF18 CASP9 IMP3 RPL19

1.62e-03995819EFO_0004518
Diseaseneutrophil-to-lymphocyte ratio

MXD3 ATAD2B ARHGEF18 GNAQ

1.71e-03185814EFO_0008447
Diseasemean platelet volume

SEMA4F FRY NFE2L1 SPTA1 ATAD2B SNX8 GNA11 BRD1 CUEDC1

1.91e-031020819EFO_0004584
Diseaselymphocyte count

MYCL APOLD1 HS6ST1 TCL1A SPTA1 SURF6 ATAD2B DEF6 ARHGEF18 GRIK5 GNAQ

2.15e-0314648111EFO_0004587

Protein segments in the cluster

PeptideGeneStartEntry
ERERVENRRAFLKLR

CACNA1A

366

O00555
AAFQRELLRKRRERE

SLC4A3

626

P48751
DLERARLLIELLRKR

BRD1

531

O95696
RLRTRLERELESLRI

AMOT

626

Q4VCS5
ERERERLELLRRLKK

ARHGEF18

1131

Q6ZSZ5
LRRLQEEARDLLERL

ATG16L2

181

Q8NAA4
RRLRREEAARLAALV

CCDC85B

26

Q15834
TLRFLKLRRERRALL

ABCA10

761

Q8WWZ4
RARLLIELIRKREKL

BRPF3

561

Q9ULD4
LRRDCRRRKVLFEDP

CAPN5

16

O15484
AELLRAERRILSRLD

CCNP

186

Q9H8S5
LRREHARLQRRLKRL

CFAP73

126

A6NFT4
KRLVEVREALTRLRR

CCDC154

151

A6NI56
LLIFLRRRLRKQARA

CDH5

616

P33151
AELLYRVRRFDLLKR

CFLAR

56

O15519
LRDRARRFEEALRKN

MTUS2

1206

Q5JR59
RDKARLLREKVEFLR

NFE2L1

691

Q14494
RPVRDRLLRERALKI

PDZRN3

936

Q9UPQ7
RLLRERALKIREERS

PDZRN3

941

Q9UPQ7
RDKRDARRELKLLLL

GNAQ

31

P50148
RDGRFVIIRREKLIL

KAT6B

951

Q8WYB5
VLRLREVARRLERLR

APOLD1

66

Q96LR9
ERDRLEGLRQRLRKA

PHLDB3

186

Q6NSJ2
TIRDRRERRKLLRFA

OGFRL1

286

Q5TC84
EKRRRAQLKRCLERL

MXD3

66

Q9BW11
RLLAEKRRLAREQRE

MAP7

481

Q14244
REENRRLRLLEPVKR

KIF15

521

Q9NS87
LIRLTEARARLELRE

MCM8

716

Q9UJA3
RELRLFLRDVTKRLA

ATAD2B

961

Q9ULI0
LLRQELRKLKRRFLE

KCNK1

51

O00180
IPVRLLRDFEERRRL

EID2B

106

Q96D98
RRFLLRAIEEKKRLD

EXOSC9

11

Q06265
RNRDFLLALERDRLK

CUEDC1

251

Q9NWM3
RFILRVRRSRLVKDA

HERC6

671

Q8IVU3
REKLRLREAEIARIR

LRRC45

626

Q96CN5
TLRELERLRELERLR

GOLGA6L19

411

H0YKK7
RELRDRERRLKSLEE

TUBGCP6

736

Q96RT7
RLETLLRRAVEKRAI

PNMA2

271

Q9UL42
LRIAARLEARRREAL

DRC1

41

Q96MC2
RLRSREERLLHRAKE

HS6ST1

371

O60243
KKIERLAELRRRFER

PABPC5

276

Q96DU9
LAELRRRFERLRLKE

PABPC5

281

Q96DU9
RSALRLEKDRVALRR

CROCC

1866

Q5TZA2
ASRDERFKRRQLLRL

KDM2A

751

Q9Y2K7
RRLLRRCRLRLVEEL

CASP9

6

P55211
RDKRDARRELKLLLL

GNA11

31

P29992
ERLERKILALRQARR

CC2D1A

856

Q6P1N0
LLARERRAVRRLVKI

GNA12

46

Q03113
RERRRAAKEEELLRL

DEF6

336

Q9H4E7
RLRRRDLLLGFNKRA

ITM2A

226

O43736
FRLKRRKRIARRLVD

ESCO2

541

Q56NI9
LSRAVRELARRLRDL

IMP3

51

Q9NV31
ELDRDALRRSRLRKV

KNDC1

291

Q76NI1
ERAERAAREDRLRKL

CCDC177

441

Q9NQR7
KRRERRDLLRLQLLR

FRY

1021

Q5TBA9
LRELAELLRFRYRLR

GRIK5

451

Q16478
ILKEDYERRRKLRLL

CEP295

21

Q9C0D2
NAERLRRKRAREVLL

MRPS16

106

Q9Y3D3
RRLRAERRRLDSALL

RUNDC1

81

Q96C34
DRLRRFLRTLRLKLA

PIF1

111

Q9H611
EELRFLRRQELRELR

SLK

821

Q9H2G2
LLELERFERRALERK

PPP1R12C

731

Q9BZL4
RRRQRELLARDKVGL

SEMA4F

686

O95754
DREFIEARRRALKRF

SNX8

141

Q9Y5X2
ILRRLLRRYRESKKI

RPL19

101

P84098
LRAAERFAKERRLRI

SND1

311

Q7KZF4
RKKAARAERRLLRAR

SURF6

331

O75683
RAERRLLRARKKGRI

SURF6

336

O75683
ELERERLRREIRKEL

PKN1

36

Q16512
LLSERRLVRAKLREV

SYCE1L

161

A8MT33
LLRLLTVKERERARA

PHF24

286

Q9UPV7
IKDRLQLRVLLRRED

TCL1A

41

P56279
EKLFRERLSQLRLRL

BRMS1

76

Q9HCU9
RLSDKDLRDLRDRDR

EIF4ENIF1

171

Q9NRA8
FLERLARREERRQKR

CALD1

96

Q05682
FVGLRERRELARRKD

SEMA6B

621

Q9H3T3
LAERLRLEERRKELL

WWC2

396

Q6AWC2
RREKRELRQVRAALL

ELAC2

781

Q9BQ52
RKRRNDLRSRFLALR

MYCL

291

P12524
RRRRREVKRRLLEEL

USP49

186

Q70CQ1
RRKLREFTQLLLREL

WDFY4

1871

Q6ZS81
SLLDRAEERRRRLLQ

SPTA1

1066

P02549
ARLIREREAKRLKRR

ZNF821

341

O75541
RRLAEKRIGVRDVRL

TENT5A

106

Q96IP4
LALILLRKRRKETRF

TYRO3

446

Q06418
ELLRERESVLRLRER

UBR5

306

O95071
DRRRAATLREKRRLK

MYOG

81

P15173