Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhistone methyltransferase binding

PAXBP1 WIZ

2.09e-0418242GO:1990226
DomainZinc_finger_PHD-type_CS

AIRE JADE2

2.88e-0365232IPR019786
DomainPHD

AIRE JADE2

3.81e-0375232PF00628
DomainZnf_PHD-finger

AIRE JADE2

4.22e-0379232IPR019787
DomainPHD

AIRE JADE2

5.32e-0389232SM00249
DomainZnf_PHD

AIRE JADE2

5.56e-0391232IPR001965
DomainZF_PHD_2

AIRE JADE2

6.04e-0395232PS50016
DomainZF_PHD_1

AIRE JADE2

6.17e-0396232PS01359
DomainSH2

TEC SH2B1

6.80e-03101232PF00017
DomainSH2

TEC SH2B1

8.02e-03110232SM00252
DomainSH2

TEC SH2B1

8.16e-03111232PS50001
DomainSH2

TEC SH2B1

8.31e-03112232IPR000980
Domain-

TEC SH2B1

8.31e-031122323.30.505.10
DomainZnf_FYVE_PHD

AIRE JADE2

1.40e-02147232IPR011011
Domain-

AIRE JADE2 DTX3

1.71e-024492333.30.40.10
DomainSH3_1

ARHGAP32 TEC

1.72e-02164232PF00018
DomainZnf_RING/FYVE/PHD

AIRE JADE2 DTX3

1.81e-02459233IPR013083
Pubmed

Reciprocal regulation of C-Maf tyrosine phosphorylation by Tec and Ptpn22.

PTPN22 TEC

1.49e-06325225993510
Pubmed

Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes.

AIRE PTPN22

1.39e-05825219264985
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

ARHGAP32 DHX37 SH2B1

1.11e-0413025312421765
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

CACNA1S ARHGAP32 PTPN22 SH2B1

2.37e-0443025435044719
Pubmed

Functional analysis and identification of cis-regulatory elements of human chromosome 21 gene promoters.

AIRE PAXBP1

2.74e-043425220494980
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

EIF3A PAXBP1 WIZ JADE2 DHX37

3.00e-0484725535850772
Pubmed

A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C.

EIF3A DHX37

4.61e-044425226471122
Pubmed

Large-scale structural analysis of the classical human protein tyrosine phosphatome.

PTPN22 TEC

5.26e-044725219167335
Pubmed

Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.

ARHGAP32 EIF3A PAXBP1 WIZ

6.05e-0455125434728620
GeneFamilyPHD finger proteins

AIRE JADE2

2.81e-039016288
GeneFamilySH2 domain containing

TEC SH2B1

3.52e-03101162741
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

TEC SH2B1

1.40e-02206162682
CoexpressionGSE7460_TREG_VS_TCONV_ACT_DN

AIRE PTPN22 TNNT1 DENND11

2.45e-05197234M5691
CoexpressionGSE411_UNSTIM_VS_100MIN_IL6_STIM_MACROPHAGE_UP

CACNA1S PAXBP1 TNNT1 DENND11

2.60e-05200234M5985
CoexpressionGSE7831_UNSTIM_VS_INFLUENZA_STIM_PDC_1H_DN

CACNA1S FBLN2 PAXBP1 TEC

2.60e-05200234M6949
ToppCellLPS-IL1RA-Lymphocytic_NKT-T_cells-Erythroid|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PTPN22 GAPDHS TEC

4.94e-05128253c2045f052cc713e52312eb015825711576fcb6c5
ToppCellfacs-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

REC8 WIZ TNNT1

5.06e-05129253cbeeaa554da971ba2e4c4b82c85a1d070a45abb8
ToppCellLPS-IL1RA-Lymphocytic_NKT-T_cells-iNKT-MAIT|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PTPN22 GAPDHS TEC

5.66e-0513425392981dc68c1b3cdc53f9cf83386c47f0c6c98ae7
ToppCellLPS-IL1RA-Hematopoietic_Mast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PTPN22 GAPDHS TEC

6.73e-05142253f7d0d5ca9fc3dd929d4fdd59b71bfa623007e992
ToppCellLPS-IL1RA-Hematopoietic_Mast-Mast_cells|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PTPN22 GAPDHS TEC

6.73e-051422532a9a070e7c53ac593d46c6c5f6983f07d4413501
ToppCellControl-Lymphocytic_NKT-iNKT/MAIT-T-cells|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PTPN22 GAPDHS TEC

7.61e-05148253003e10bf477984248211b99d75daa8f7dcdb12c8
ToppCellControl-Lymphocytic_NKT-T_cells-iNKT-MAIT|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PTPN22 WIZ TEC

8.07e-051512537e5e35ce601ca3d3722063566e89664909171b8d
ToppCell368C-Myeloid-Macrophage-SPP1+_Macrophage|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

AIRE SCAF1 ZNF219

9.58e-051602536d941e584360975e1fdbb2fc67af8e31f18759d8
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PTPN22 FBLN2 WIZ

1.05e-0416525362457b7b74c6eae42d91d65e7dc6df6bf8e061f7
ToppCelldroplet-Lung-1m-Hematologic-lymphocytic-regulatory_T_cell-regulatory_T_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PTPN22 TNNT1 DHX37

1.23e-0417425333386750842c47ad7e7286d0f26a556da1a2de02
ToppCelldroplet-Lung-1m-Hematologic-lymphocytic-regulatory_T_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PTPN22 TNNT1 DHX37

1.23e-041742539344d4e76d7d9429aea87d3c0b98246200d16014
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

PTPN22 JADE2 DTX3

1.27e-041762536b1cf1e98b4509e87f9eea827fa7090ce1e504f1
ToppCellSevere-B_intermediate-10|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

AIRE CACNA1S FBLN2

1.31e-04178253b7374a97c51239782bed658381a02cb1b3d9bf66
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PTPN22 PAXBP1 JADE2

1.38e-04181253986c036e656f24fe374807e2711cec9e3c83c892
ToppCellControl-Lymphocytic_NKT-iNKT/MAIT|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PTPN22 GAPDHS TEC

1.43e-0418325359e8d07556390828f7557ba3fd2f7d49851498b7
ToppCelldroplet-Thymus-nan-18m-Myeloid-Plasma_cells_and_B_cells|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AIRE CACNA1S ANTXR2

1.43e-04183253ffb1bbbccb34d1a7e99872611f497450039d5019
ToppCellE18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARHGAP32 WIZ JADE2

1.45e-04184253a6dee97ee4ef9d89e11d17339e0dadaea1210ce5
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

ANTXR2 DENND11 ATAD2B

1.45e-04184253e6bf826be31e1723e24c366fc5a1cee9b15589bc
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

PTPN22 JADE2 DTX3

1.47e-04185253f1263899a2d41d182022dc4ca62cbae08a463c89
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

PTPN22 JADE2 DTX3

1.50e-04186253bbcd9062c0f6f65ca6f3cb101b6fa72ddd1e14fe
Drugsilaned

AIRE ARHGAP32 PTPN22 TNNT1

1.14e-0743244CID006335299
DrugX-GlcA

GAPDHS TEC

2.97e-058242CID002733578
Drug(+)-Isoproterenol (+)-bitartrate salt [14638-70-1]; Down 200; 11uM; HL60; HT_HG-U133A

REC8 PTPN22 WIZ TEC

4.56e-051922443046_DN
Drugdi-n-butyl sebacate

TEC TNNT1

4.77e-0510242CID000007986
DrugChlortetracycline hydrochloride [64-72-2]; Up 200; 7.8uM; PC3; HT_HG-U133A

REC8 AIRE PTPN22 WIZ

4.85e-051952446761_UP
DrugProtoveratrine A [143-57-7]; Up 200; 5uM; MCF7; HT_HG-U133A

REC8 CACNA1S PTPN22 SH2B1

4.95e-051962444963_UP
DrugCefotaxime sodium salt [64485-93-4]; Down 200; 8.4uM; PC3; HT_HG-U133A

ARHGAP32 EIF3A WIZ SH2B1

5.04e-051972442072_DN
DrugBendroflumethiazide [73-48-3]; Up 200; 9.4uM; PC3; HT_HG-U133A

REC8 AIRE WIZ SH2B1

5.04e-051972444315_UP
DrugMethacholine chloride [62-51-1]; Up 200; 20.4uM; PC3; HT_HG-U133A

AIRE WIZ DTX3 SH2B1

5.04e-051972445773_UP
DrugSulfamethizole [144-82-1]; Up 200; 14.8uM; PC3; HT_HG-U133A

REC8 PTPN22 WIZ DTX3

5.04e-051972445798_UP
DrugRolipram [61413-54-5]; Up 200; 14.6uM; MCF7; HT_HG-U133A

REC8 CACNA1S WIZ DTX3

5.04e-051972446449_UP
DrugSulfamerazine [127-79-7]; Up 200; 15.2uM; PC3; HT_HG-U133A

ZNF219 WIZ JADE2 DTX3

5.25e-051992443718_UP
DrugS010

ARHGAP32 TEC

6.98e-0512242CID006452892
Diseaserheumatoid arthritis, anti-citrullinated protein antibody seropositivity, rheumatoid factor seropositivity measurement

AIRE PTPN22 ANTXR2 TEC TEC

1.85e-07170235EFO_0000685, EFO_0007791, EFO_0007837
Diseasetyrosine-protein kinase TEC measurement

TEC TEC

3.48e-064232EFO_0020830
Diseasemyositis

PTPN22 TEC TEC

3.71e-0639233EFO_0000783
Diseaserheumatoid arthritis

AIRE PTPN22 ANTXR2 TEC TEC

2.45e-05462235EFO_0000685
DiseaseGenetic chronic primary adrenal insufficiency

AIRE PTPN22

4.51e-0513232Orphanet_101960
Diseasecystathionine measurement

TEC TEC

9.86e-0519232EFO_0010474
DiseaseProstatic Neoplasms

REC8 EIF3A ANTXR2 JADE2

1.21e-03616234C0033578
DiseaseMalignant neoplasm of prostate

REC8 EIF3A ANTXR2 JADE2

1.21e-03616234C0376358
Diseasecigarettes per day measurement

ITPKC JADE2 SH2B1

4.61e-03438233EFO_0006525

Protein segments in the cluster

PeptideGeneStartEntry
VKIPEETEEPIRPRP

ANTXR2

416

P58335
RAEEPRPQEPPVETP

AIRE

351

O43918
AAIPERVEEIPPEVP

REC8

161

O95072
RVEEIPPEVPTEPRE

REC8

166

O95072
TEPREPERIPVTVLP

REC8

176

O95072
PVPRLIITPETPEPE

ITPKC

326

Q96DU7
APRIDDEIPPPLPVR

PTPN22

606

Q9Y2R2
PVREPERYPLPTVLP

FAM166C

141

A6NJV1
EPSEPVPPLIVDRER

ATAD2B

1386

Q9ULI0
EAIPEPVVRILPPLE

JADE2

96

Q9NQC1
EEPLIVPEVRRPPEP

FBLN2

556

P98095
RERDEEQEPPPLLPP

PAXBP1

21

Q9Y5B6
VVPVPERPPEPRAMD

ARHGAP32

1341

A7KAX9
PPPLPPRLREEAEEQ

DTX3

146

Q8N9I9
VEERDPPRRVPPPAL

EIF3A

1321

Q14152
EEDEPEIPLSPRPRP

CACNA1S

746

Q13698
EEEVRRELALPPPDP

GAS2L2

176

Q8NHY3
PPRRREPEEPAAPEV

DENND11

46

A4D1U4
VEPQPQPEPTPVREE

GAPDHS

36

O14556
PPPEITRRPVEDLIL

DHX37

696

Q8IY37
PRPPRPAETKVPEEI

NUTM2G

361

Q5VZR2
ELLPPELPPRIPIEE

SH2B1

466

Q9NRF2
EEERPKPSRPVVPPL

TNNT1

36

P13805
RRPPPPIPLEEEDNS

TEC

166

P42680
LEEVRQPPPRVRPVP

WIZ

1561

O95785
EVRIGDRDPIPLPVP

SCAF1

131

Q9H7N4
RSVPQPEPEPEPERE

ZNF219

241

Q9P2Y4