Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	low voltage-gated calcium channel activity	CACNA1I CACNA1H	2.66e-05	3	60	2	GO:0008332
GeneOntologyMolecularFunction	carbon dioxide transmembrane transporter activity	RHCG RHAG	5.31e-05	4	60	2	GO:0035379
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	SP1 SOX21 UNCX DACH2 MNX1 NKX2-1 POU3F1 DMRTA2 POU3F2 POU3F3 PAX2 ONECUT3 ZNF513	2.36e-04	1412	60	13	GO:0000981
GeneOntologyMolecularFunction	ammonium channel activity	RHCG RHAG	5.75e-04	12	60	2	GO:0008519
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNA1I CACNA1H	7.89e-04	14	60	2	GO:0008331
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	SP1 SOX21 DACH2 NKX2-1 POU3F1 DMRTA2 POU3F2 POU3F3 PAX2 ONECUT3 ZNF513	1.07e-03	1244	60	11	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	SP1 SOX21 DACH2 NKX2-1 POU3F1 DMRTA2 POU3F2 POU3F3 PAX2 ONECUT3 ZNF513	1.27e-03	1271	60	11	GO:0000987
GeneOntologyMolecularFunction	HMG box domain binding	POU3F2 POU3F3	2.16e-03	23	60	2	GO:0071837
GeneOntologyMolecularFunction	ankyrin binding	RHCG RHAG	2.16e-03	23	60	2	GO:0030506
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	CACNA1I CACNA1H	2.75e-03	26	60	2	GO:0005248
GeneOntologyBiologicalProcess	brain development	HSPG2 FLNA SOX21 UNCX NKX2-1 POU3F1 DMRTA2 POU3F2 POU3F3 CHD8 PAX2	1.37e-05	859	55	11	GO:0007420
GeneOntologyBiologicalProcess	metanephric DCT cell differentiation	POU3F3 PAX2	2.09e-05	3	55	2	GO:0072240
GeneOntologyBiologicalProcess	DCT cell differentiation	POU3F3 PAX2	2.09e-05	3	55	2	GO:0072069
GeneOntologyBiologicalProcess	metanephric nephron tubule development	POU3F3 WWTR1 PAX2	2.31e-05	21	55	3	GO:0072234
GeneOntologyBiologicalProcess	head development	HSPG2 FLNA SOX21 UNCX NKX2-1 POU3F1 DMRTA2 POU3F2 POU3F3 CHD8 PAX2	2.56e-05	919	55	11	GO:0060322
GeneOntologyBiologicalProcess	cell differentiation involved in metanephros development	POU3F3 WWTR1 PAX2	2.67e-05	22	55	3	GO:0072202
GeneOntologyBiologicalProcess	metanephric nephron epithelium development	POU3F3 WWTR1 PAX2	3.06e-05	23	55	3	GO:0072243
GeneOntologyBiologicalProcess	carbon dioxide transmembrane transport	RHCG RHAG	4.17e-05	4	55	2	GO:0035378
GeneOntologyBiologicalProcess	metanephric tubule development	POU3F3 WWTR1 PAX2	4.47e-05	26	55	3	GO:0072170
GeneOntologyBiologicalProcess	cerebral cortex development	FLNA NKX2-1 DMRTA2 POU3F2 POU3F3	4.48e-05	147	55	5	GO:0021987
GeneOntologyBiologicalProcess	metanephric epithelium development	POU3F3 WWTR1 PAX2	5.61e-05	28	55	3	GO:0072207
GeneOntologyBiologicalProcess	central nervous system development	HSPG2 FLNA SOX21 UNCX MNX1 NKX2-1 POU3F1 DMRTA2 POU3F2 POU3F3 CHD8 PAX2	5.92e-05	1197	55	12	GO:0007417
GeneOntologyBiologicalProcess	metanephric distal convoluted tubule development	POU3F3 PAX2	6.95e-05	5	55	2	GO:0072221
GeneOntologyBiologicalProcess	metanephric distal tubule development	POU3F3 PAX2	6.95e-05	5	55	2	GO:0072235
GeneOntologyBiologicalProcess	distal convoluted tubule development	POU3F3 PAX2	6.95e-05	5	55	2	GO:0072025
GeneOntologyBiologicalProcess	one-carbon compound transport	RHCG POU3F3 RHAG	9.25e-05	33	55	3	GO:0019755
GeneOntologyBiologicalProcess	neuron fate commitment	MNX1 NKX2-1 DMRTA2 POU3F2	1.02e-04	91	55	4	GO:0048663
GeneOntologyBiologicalProcess	forebrain ventricular zone progenitor cell division	POU3F2 POU3F3	1.04e-04	6	55	2	GO:0021869
GeneOntologyBiologicalProcess	ammonium homeostasis	RHCG RHAG	1.04e-04	6	55	2	GO:0097272
GeneOntologyBiologicalProcess	regulation of metanephric nephron tubule epithelial cell differentiation	WWTR1 PAX2	1.45e-04	7	55	2	GO:0072307
GeneOntologyBiologicalProcess	metanephric nephron tubule epithelial cell differentiation	WWTR1 PAX2	1.45e-04	7	55	2	GO:0072257
GeneOntologyBiologicalProcess	neuron fate specification	MNX1 DMRTA2 POU3F2	1.91e-04	42	55	3	GO:0048665
GeneOntologyBiologicalProcess	regulation of calcium ion-dependent exocytosis	SYT3 CACNA1I CACNA1H	2.35e-04	45	55	3	GO:0017158
GeneOntologyBiologicalProcess	telencephalon development	FLNA UNCX NKX2-1 DMRTA2 POU3F2 POU3F3	2.48e-04	332	55	6	GO:0021537
GeneOntologyBiologicalProcess	forebrain development	FLNA UNCX NKX2-1 POU3F1 DMRTA2 POU3F2 POU3F3	3.06e-04	489	55	7	GO:0030900
GeneOntologyBiologicalProcess	distal tubule development	POU3F3 PAX2	3.10e-04	10	55	2	GO:0072017
GeneOntologyBiologicalProcess	pallium development	FLNA NKX2-1 DMRTA2 POU3F2 POU3F3	3.10e-04	222	55	5	GO:0021543
GeneOntologyBiologicalProcess	cell fate specification	MNX1 DMRTA2 POU3F2 PAX2	3.25e-04	123	55	4	GO:0001708
GeneOntologyBiologicalProcess	cerebral cortex cell migration	NKX2-1 POU3F2 POU3F3	4.50e-04	56	55	3	GO:0021795
GeneOntologyBiologicalProcess	cell differentiation involved in kidney development	POU3F3 WWTR1 PAX2	4.74e-04	57	55	3	GO:0061005
GeneOntologyBiologicalProcess	regulation of nephron tubule epithelial cell differentiation	WWTR1 PAX2	5.34e-04	13	55	2	GO:0072182
GeneOntologyBiologicalProcess	ammonium transmembrane transport	RHCG RHAG	5.34e-04	13	55	2	GO:0072488
GeneOntologyBiologicalProcess	neuronal action potential	KCNC4 CACNA1I CACNA1H	6.36e-04	63	55	3	GO:0019228
GeneOntologyBiologicalProcess	nephron tubule epithelial cell differentiation	WWTR1 PAX2	7.17e-04	15	55	2	GO:0072160
GeneOntologyBiologicalProcess	telencephalon cell migration	NKX2-1 POU3F2 POU3F3	9.39e-04	72	55	3	GO:0022029
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	SP1 SOX21 NKX2-1 POU3F1 POU3F2 POU3F3 CHD8 WWTR1 PAX2 ONECUT3 ZNF513	9.55e-04	1390	55	11	GO:0045944
GeneOntologyBiologicalProcess	forebrain cell migration	NKX2-1 POU3F2 POU3F3	1.06e-03	75	55	3	GO:0021885
GeneOntologyBiologicalProcess	regulation of epithelial cell differentiation involved in kidney development	WWTR1 PAX2	1.16e-03	19	55	2	GO:2000696
GeneOntologyBiologicalProcess	carbon dioxide transport	RHCG RHAG	1.16e-03	19	55	2	GO:0015670
GeneOntologyBiologicalProcess	positive regulation of calcium ion-dependent exocytosis	CACNA1I CACNA1H	1.29e-03	20	55	2	GO:0045956
GeneOntologyBiologicalProcess	calcium-ion regulated exocytosis	SYT3 CACNA1I CACNA1H	1.37e-03	82	55	3	GO:0017156
GeneOntologyCellularComponent	chromatin	SP1 SLF1 SOX21 UNCX MNX1 NKX2-1 POU3F1 DMRTA2 POU3F2 POU3F3 CHD8 PAX2 ONECUT3	2.39e-04	1480	60	13	GO:0000785
GeneOntologyCellularComponent	transcription regulator complex	SP1 DACH2 NKX2-1 POU3F1 POU3F2 WWTR1 PAX2 ONECUT3	2.89e-04	596	60	8	GO:0005667
Domain	TF_POU_3	POU3F1 POU3F2 POU3F3	1.20e-07	4	59	3	IPR016362
Domain	-	POU3F1 POU3F2 POU3F3 ONECUT3	1.49e-06	27	59	4	1.10.260.40
Domain	Lambda_DNA-bd_dom	POU3F1 POU3F2 POU3F3 ONECUT3	2.01e-06	29	59	4	IPR010982
Domain	-	UNCX MNX1 NKX2-1 POU3F1 POU3F2 POU3F3 PAX2 ONECUT3	2.86e-06	283	59	8	1.10.10.60
Domain	Homeobox	UNCX MNX1 NKX2-1 POU3F1 POU3F2 POU3F3 ONECUT3	8.68e-06	234	59	7	PF00046
Domain	HOMEOBOX_1	UNCX MNX1 NKX2-1 POU3F1 POU3F2 POU3F3 ONECUT3	9.18e-06	236	59	7	PS00027
Domain	Homeodomain-like	UNCX MNX1 NKX2-1 POU3F1 POU3F2 POU3F3 PAX2 ONECUT3	9.23e-06	332	59	8	IPR009057
Domain	HOX	UNCX MNX1 NKX2-1 POU3F1 POU3F2 POU3F3 ONECUT3	9.44e-06	237	59	7	SM00389
Domain	HOMEOBOX_2	UNCX MNX1 NKX2-1 POU3F1 POU3F2 POU3F3 ONECUT3	9.97e-06	239	59	7	PS50071
Domain	Homeobox_dom	UNCX MNX1 NKX2-1 POU3F1 POU3F2 POU3F3 ONECUT3	9.97e-06	239	59	7	IPR001356
Domain	POU	POU3F1 POU3F2 POU3F3	1.63e-05	16	59	3	SM00352
Domain	POU_2	POU3F1 POU3F2 POU3F3	1.63e-05	16	59	3	PS00465
Domain	POU_dom	POU3F1 POU3F2 POU3F3	1.63e-05	16	59	3	IPR000327
Domain	POU_3	POU3F1 POU3F2 POU3F3	1.63e-05	16	59	3	PS51179
Domain	Pou	POU3F1 POU3F2 POU3F3	1.63e-05	16	59	3	PF00157
Domain	POU_1	POU3F1 POU3F2 POU3F3	1.63e-05	16	59	3	PS00035
Domain	POU	POU3F1 POU3F2 POU3F3	1.97e-05	17	59	3	IPR013847
Domain	Homeobox_CS	UNCX MNX1 NKX2-1 POU3F1 POU3F2 POU3F3	2.62e-05	186	59	6	IPR017970
Domain	VDCC_T_a1	CACNA1I CACNA1H	2.94e-05	3	59	2	IPR005445
Domain	Fumarylacetoacetase_C-rel	FAHD2B FAHD2A	5.86e-05	4	59	2	IPR011234
Domain	FAA_hydrolase	FAHD2B FAHD2A	5.86e-05	4	59	2	PF01557
Domain	-	FAHD2B FAHD2A	5.86e-05	4	59	2	3.90.850.10
Domain	Ammonium_transpt	RHCG RHAG	9.75e-05	5	59	2	IPR001905
Domain	Ammonium_transp	RHCG RHAG	9.75e-05	5	59	2	PF00909
Domain	NH4_transpt_AmtB-like_dom	RHCG RHAG	9.75e-05	5	59	2	IPR024041
Domain	RhesusRHD	RHCG RHAG	9.75e-05	5	59	2	IPR002229
Domain	-	RHCG RHAG	2.04e-04	7	59	2	1.10.3430.10
Domain	Ammonium/urea_transptr	RHCG RHAG	2.04e-04	7	59	2	IPR029020
Domain	VDCCAlpha1	CACNA1I CACNA1H	4.34e-04	10	59	2	IPR002077
Domain	Channel_four-helix_dom	KCNC4 CACNA1I CACNA1H	7.76e-04	57	59	3	IPR027359
Domain	-	KCNC4 CACNA1I CACNA1H	7.76e-04	57	59	3	1.20.120.350
Domain	Collagen	COL8A2 COL20A1 COL1A2	2.46e-03	85	59	3	IPR008160
Domain	Collagen	COL8A2 COL20A1 COL1A2	2.46e-03	85	59	3	PF01391
Domain	Ion_trans_dom	KCNC4 CACNA1I CACNA1H	5.62e-03	114	59	3	IPR005821
Domain	Ion_trans	KCNC4 CACNA1I CACNA1H	5.62e-03	114	59	3	PF00520
Pathway	REACTOME_EGR2_AND_SOX10_MEDIATED_INITIATION_OF_SCHWANN_CELL_MYELINATION	POU3F1 POU3F2 WWTR1	7.92e-05	29	41	3	M29808
Pathway	REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION	SP1 WWTR1 COL1A2	1.53e-04	36	41	3	M633
Pathway	REACTOME_COLLAGEN_CHAIN_TRIMERIZATION	COL8A2 COL20A1 COL1A2	2.25e-04	41	41	3	MM15538
Pathway	REACTOME_COLLAGEN_CHAIN_TRIMERIZATION	COL8A2 COL20A1 COL1A2	2.78e-04	44	41	3	M27812
Pathway	REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER	SP1 WWTR1 COL1A2	4.32e-04	51	41	3	M665
Pathway	REACTOME_COLLAGEN_DEGRADATION	PRSS3 COL8A2 COL1A2	4.84e-04	53	41	3	MM14566
Pathway	REACTOME_GP1B_IX_V_ACTIVATION_SIGNALLING	FLNA COL1A2	5.35e-04	12	41	2	MM15093
Pathway	REACTOME_GP1B_IX_V_ACTIVATION_SIGNALLING	FLNA COL1A2	5.35e-04	12	41	2	M27352
Pathway	REACTOME_NEPHRON_DEVELOPMENT	POU3F3 PAX2	6.31e-04	13	41	2	M48245
Pathway	REACTOME_COLLAGEN_BIOSYNTHESIS_AND_MODIFYING_ENZYMES	COL8A2 COL20A1 COL1A2	7.31e-04	61	41	3	MM14637
Pathway	REACTOME_COLLAGEN_BIOSYNTHESIS_AND_MODIFYING_ENZYMES	COL8A2 COL20A1 COL1A2	9.61e-04	67	41	3	M26999
Pubmed	Identification of Pax2-regulated genes by expression profiling of the mid-hindbrain organizer region.	POU3F1 POU3F2 POU3F3 PAX2	1.07e-09	9	61	4	15872005
Pubmed	Structure and evolution of four POU domain genes expressed in mouse brain.	POU3F1 POU3F2 POU3F3	2.05e-08	4	61	3	1565620
Pubmed	Selective influence of Sox2 on POU transcription factor binding in embryonic and neural stem cells.	POU3F1 POU3F2 POU3F3	2.05e-08	4	61	3	26265007
Pubmed	A census of human transcription factors: function, expression and evolution.	SP1 SOX21 UNCX DACH2 MNX1 NKX2-1 POU3F1 DMRTA2 POU3F2 POU3F3 PAX2 ONECUT3	5.02e-08	908	61	12	19274049
Pubmed	The class III POU factor Brn-4 interacts with other class III POU factors and the heterogeneous nuclear ribonucleoprotein U.	POU3F1 POU3F2 POU3F3	5.12e-08	5	61	3	9105675
Pubmed	Cooperative function of POU proteins and SOX proteins in glial cells.	POU3F1 POU3F2 POU3F3	5.12e-08	5	61	3	9632656
Pubmed	Expression of a large family of POU-domain regulatory genes in mammalian brain development.	POU3F1 POU3F2 POU3F3	1.02e-07	6	61	3	2739723
Pubmed	Hippocampus-like corticoneurogenesis induced by two isoforms of the BTB-zinc finger gene Zbtb20 in mice.	POU3F1 POU3F2 POU3F3	1.79e-07	7	61	3	17301088
Pubmed	Murine chromosomal location of four class III POU transcription factors.	POU3F1 POU3F2 POU3F3	1.12e-06	12	61	3	8276397
Pubmed	Expression of Pou3f3/Brn-1 and its genomic methylation in developing auditory epithelium.	POU3F2 POU3F3 PAX2	1.12e-06	12	61	3	19743445
Pubmed	Development and survival of the endocrine hypothalamus and posterior pituitary gland requires the neuronal POU domain factor Brn-2.	POU3F1 POU3F2 POU3F3	1.45e-06	13	61	3	8543156
Pubmed	Proneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motif.	POU3F1 POU3F2 POU3F3	1.84e-06	14	61	3	17141158
Pubmed	Satb2 is a postmitotic determinant for upper-layer neuron specification in the neocortex.	POU3F1 POU3F2 POU3F3	2.30e-06	15	61	3	18255031
Pubmed	Two Pairs of ON and OFF Retinal Ganglion Cells Are Defined by Intersectional Patterns of Transcription Factor Expression.	MNX1 POU3F1 PAX2 ONECUT3	2.35e-06	53	61	4	27210758
Pubmed	The winged helix gene, Mf3, is required for normal development of the diencephalon and midbrain, postnatal growth and the milk-ejection reflex.	POU3F1 POU3F2 POU3F3	2.83e-06	16	61	3	9118797
Pubmed	Dynamic expression of the Onecut transcription factors HNF-6, OC-2 and OC-3 during spinal motor neuron development.	MNX1 POU3F1 ONECUT3	2.83e-06	16	61	3	19800948
Pubmed	Replacement of related POU transcription factors leads to severe defects in mouse forebrain development.	POU3F1 POU3F2 POU3F3	2.83e-06	16	61	3	19527706
Pubmed	Differential expression of murine CGI-105 gene in 3T3-L1 cells by adrenocorticotropic hormones.	FAHD2B FAHD2A	3.03e-06	2	61	2	15774318
Pubmed	A T-type calcium channel required for normal function of a mammalian mechanoreceptor.	CACNA1I CACNA1H	3.03e-06	2	61	2	12808460
Pubmed	Identification of the nuclear localization signal of the POU domain protein Tst-1/Oct6.	POU3F1 POU3F3	3.03e-06	2	61	2	8663425
Pubmed	Neural lineage-specific homeoprotein BRN2 is directly involved in TTF1 expression in small-cell lung cancer.	NKX2-1 POU3F2	3.03e-06	2	61	2	23358112
Pubmed	Rebound burst firing in the reticular thalamus is not essential for pharmacological absence seizures in mice.	CACNA1I CACNA1H	3.03e-06	2	61	2	25071191
Pubmed	The Rh complex exports ammonium from human red blood cells.	RHCG RHAG	3.03e-06	2	61	2	12846905
Pubmed	Whole Exome Sequencing of Hemiplegic Migraine Patients Shows an Increased Burden of Missense Variants in CACNA1H and CACNA1I Genes.	CACNA1I CACNA1H	3.03e-06	2	61	2	36786913
Pubmed	The challenge of understanding ammonium homeostasis and the role of the Rh glycoproteins.	RHCG RHAG	3.03e-06	2	61	2	16564724
Pubmed	Human class III POU genes, POU3F1 and POU3F3, map to chromosomes 1p34.1 and 3p14.2.	POU3F1 POU3F3	3.03e-06	2	61	2	9457692
Pubmed	RhCG is downregulated in oesophageal squamous cell carcinomas, but expressed in multiple squamous epithelia.	RHCG RHAG	3.03e-06	2	61	2	12204676
Pubmed	Isolation of cDNA clones for a 50 kDa glycoprotein of the human erythrocyte membrane associated with Rh (rhesus) blood-group antigen expression.	RHCG RHAG	3.03e-06	2	61	2	1417776
Pubmed	The human Rhesus-associated RhAG protein and a kidney homologue promote ammonium transport in yeast.	RHCG RHAG	3.03e-06	2	61	2	11062476
Pubmed	MicroRNA-9 regulates neurogenesis in mouse telencephalon by targeting multiple transcription factors.	RHCG NKX2-1 POLG POU3F2	3.15e-06	57	61	4	21368052
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	SP1 UNCX MNX1 POU3F1 DMRTA2 POU3F2 PAX2 ONECUT3	4.84e-06	544	61	8	28473536
Pubmed	Transcriptional regulation of cortical neuron migration by POU domain factors.	POU3F1 POU3F2 POU3F3	5.73e-06	20	61	3	11859196
Pubmed	SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function.	SOX21 MNX1 PAX2	7.72e-06	22	61	3	17084361
Pubmed	DMRT5 Together with DMRT3 Directly Controls Hippocampus Development and Neocortical Area Map Formation.	POU3F1 DMRTA2 PAX2	8.87e-06	23	61	3	28031177
Pubmed	Ethanol inhibition of a T-type Ca²+ channel through activity of protein kinase C.	CACNA1I CACNA1H	9.07e-06	3	61	2	23488970
Pubmed	T-type channels: release a brake, engage a gear.	CACNA1I CACNA1H	9.07e-06	3	61	2	26488564
Pubmed	Differential interactions of Na+ channel toxins with T-type Ca2+ channels.	CACNA1I CACNA1H	9.07e-06	3	61	2	18591418
Pubmed	Class III POU genes: generation of homopolymeric amino acid repeats under GC pressure in mammals.	POU3F2 POU3F3	9.07e-06	3	61	2	8703082
Pubmed	Identification of the t-type calcium channel (Ca(v)3.1d) in developing mouse heart.	CACNA1I CACNA1H	9.07e-06	3	61	2	11230107
Pubmed	Prognostic relevance of a T-type calcium channels gene signature in solid tumours: A correlation ready for clinical validation.	CACNA1I CACNA1H	9.07e-06	3	61	2	28846697
Pubmed	Knockdown of HDAC10 inhibits POLE2-mediated DNA damage repair in NSCLC cells by increasing SP1 acetylation levels.	SP1 HDAC10	9.07e-06	3	61	2	37657752
Pubmed	Homeostatic plasticity and burst activity are mediated by hyperpolarization-activated cation currents and T-type calcium channels in neuronal cultures.	CACNA1I CACNA1H	9.07e-06	3	61	2	33547341
Pubmed	Calmodulin regulates Cav3 T-type channels at their gating brake.	CACNA1I CACNA1H	9.07e-06	3	61	2	28972185
Pubmed	Specific contribution of human T-type calcium channel isotypes (alpha(1G), alpha(1H) and alpha(1I)) to neuronal excitability.	CACNA1I CACNA1H	9.07e-06	3	61	2	11927664
Pubmed	Pax2.1 is required for the development of thyroid follicles in zebrafish.	NKX2-1 PAX2	9.07e-06	3	61	2	12117823
Pubmed	Mechanisms of ammonia and ammonium transport by rhesus-associated glycoproteins.	RHCG RHAG	9.07e-06	3	61	2	26354748
Pubmed	A universal metabolite repair enzyme removes a strong inhibitor of the TCA cycle.	FAHD2B FAHD2A	9.07e-06	3	61	2	38287013
Pubmed	Relative CO₂/NH₃ permeabilities of human RhAG, RhBG and RhCG.	RHCG RHAG	9.07e-06	3	61	2	24077989
Pubmed	Interaction of p38 and Sp1 in a mechanical force-induced, beta 1 integrin-mediated transcriptional circuit that regulates the actin-binding protein filamin-A.	SP1 FLNA	9.07e-06	3	61	2	12324467
Pubmed	Alpha(1H) mRNA in single skeletal muscle fibres accounts for T-type calcium current transient expression during fetal development in mice.	CACNA1I CACNA1H	9.07e-06	3	61	2	11897840
Pubmed	The Sox2 regulatory region 2 functions as a neural stem cell-specific enhancer in the telencephalon.	POU3F2 POU3F3	9.07e-06	3	61	2	16547000
Pubmed	Human Rhesus B and Rhesus C glycoproteins: properties of facilitated ammonium transport in recombinant kidney cells.	RHCG RHAG	9.07e-06	3	61	2	15929723
Pubmed	Ezh2 represses the basal cell lineage during lung endoderm development.	NKX2-1 POU3F3 PAX2	1.01e-05	24	61	3	25516972
Pubmed	Development, maturation, and necessity of transcription factors in the mouse suprachiasmatic nucleus.	SOX21 NKX2-1 POU3F1 POU3F2	1.05e-05	77	61	4	21525287
Pubmed	Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells.	POU3F1 POU3F2 POU3F3	1.30e-05	26	61	3	22992956
Pubmed	Transcriptional coactivator with PDZ-binding motif is essential for normal alveolarization in mice.	NKX2-1 WWTR1 COL1A2	1.46e-05	27	61	3	19498055
Pubmed	Myocardin-related transcription factor-A complexes activate type I collagen expression in lung fibroblasts.	SP1 COL1A2	1.81e-05	4	61	2	22049076
Pubmed	Mutually repressive interaction between Brn1/2 and Rorb contributes to the establishment of neocortical layer 2/3 and layer 4.	POU3F2 POU3F3	1.81e-05	4	61	2	26951672
Pubmed	Gbx2 directly restricts Otx2 expression to forebrain and midbrain, competing with class III POU factors.	POU3F1 POU3F2	1.81e-05	4	61	2	22566684
Pubmed	A POU factor binding site upstream of the Chx10 homeobox gene is required for Chx10 expression in subsets of retinal progenitor cells and bipolar cells.	POU3F1 POU3F2	1.81e-05	4	61	2	15893976
Pubmed	Pharmacogenetics of antiepileptic drug efficacy in childhood absence epilepsy.	CACNA1I CACNA1H	1.81e-05	4	61	2	28165634
Pubmed	Rh-RhAG/ankyrin-R, a new interaction site between the membrane bilayer and the red cell skeleton, is impaired by Rh(null)-associated mutation.	RHCG RHAG	1.81e-05	4	61	2	12719424
Pubmed	Transport characteristics of mammalian Rh and Rh glycoproteins expressed in heterologous systems.	RHCG RHAG	1.81e-05	4	61	2	16563829
Pubmed	TAZ is a coactivator for Pax8 and TTF-1, two transcription factors involved in thyroid differentiation.	NKX2-1 WWTR1	1.81e-05	4	61	2	19010321
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	HSPG2 FLNA INTS5 POLG CHD8 CACNA1H PAX2 WRAP53 ZNF839 AHNAK2	2.08e-05	1105	61	10	35748872
Pubmed	Yap and Taz are required for Ret-dependent urinary tract morphogenesis.	UNCX WWTR1 PAX2	2.23e-05	31	61	3	26243870
Pubmed	The POU domain transcription factors Oct-6 and Oct-11 negatively regulate loricrin gene expression in keratinocytes: association with AP-1 and Sp1/Sp3.	SP1 POU3F1	3.02e-05	5	61	2	23341029
Pubmed	Evolutionary conservation and diversification of Rh family genes and proteins.	RHCG RHAG	3.02e-05	5	61	2	16227429
Pubmed	Yap/Taz inhibit goblet cell fate to maintain lung epithelial homeostasis.	NKX2-1 WWTR1	3.02e-05	5	61	2	34260916
Pubmed	TAZ interacts with TTF-1 and regulates expression of surfactant protein-C.	NKX2-1 WWTR1	3.02e-05	5	61	2	14970209
Pubmed	The POU proteins Brn-2 and Oct-6 share important functions in Schwann cell development.	POU3F1 POU3F2	3.02e-05	5	61	2	12782656
Pubmed	Chondroitin sulphate decreases collagen synthesis in normal and scleroderma fibroblasts through a Smad-independent TGF-beta pathway--implication of C-Krox and Sp1.	SP1 COL1A2	3.02e-05	5	61	2	18298657
Pubmed	Expression of Nephronectin in the Descemet's membrane of mouse corneas during development and adult homeostasis.	HSPG2 COL8A2	3.02e-05	5	61	2	38246333
Pubmed	PRC1 sustains the integrity of neural fate in the absence of PRC2 function.	MNX1 NKX2-1 POU3F1	4.15e-05	38	61	3	34994686
Pubmed	Sox12 deletion in the mouse reveals nonreciprocal redundancy with the related Sox4 and Sox11 transcription factors.	POU3F1 POU3F2	4.52e-05	6	61	2	18505825
Pubmed	The Pou5f1/Pou3f-dependent but SoxB-independent regulation of conserved enhancer N2 initiates Sox2 expression during epiblast to neural plate stages in vertebrates.	POU3F1 POU3F2	4.52e-05	6	61	2	21185279
Pubmed	Embryonic origins of ZebrinII parasagittal stripes and establishment of topographic Purkinje cell projections.	POU3F2 PAX2	4.52e-05	6	61	2	19150487
Pubmed	Hox/Pbx and Brn binding sites mediate Pax3 expression in vitro and in vivo.	POU3F2 POU3F3	4.52e-05	6	61	2	15465489
Pubmed	The requirement for Phr1 in CNS axon tract formation reveals the corticostriatal boundary as a choice point for cortical axons.	MNX1 MAP3K12	4.52e-05	6	61	2	17901218
Pubmed	Conserved POU binding DNA sites in the Sox2 upstream enhancer regulate gene expression in embryonic and neural stem cells.	POU3F2 POU3F3	4.52e-05	6	61	2	15262984
Pubmed	The class III POU domain protein Brn-1 can fully replace the related Oct-6 during schwann cell development and myelination.	POU3F1 POU3F3	4.52e-05	6	61	2	15713637
Pubmed	Tumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivators.	POU3F1 POU3F3 WWTR1	5.61e-05	42	61	3	23863479
Pubmed	ZPK/DLK, a mitogen-activated protein kinase kinase kinase, is a critical mediator of programmed cell death of motoneurons.	MNX1 MAP3K12	6.32e-05	7	61	2	21593306
Pubmed	Filamin A-interacting protein (FILIP) is a region-specific modulator of myosin 2b and controls spine morphology and NMDA receptor accumulation.	FLNA POU3F3	6.32e-05	7	61	2	25220605
Pubmed	Yap- and Cdc42-dependent nephrogenesis and morphogenesis during mouse kidney development.	UNCX WWTR1 PAX2	7.38e-05	46	61	3	23555292
Pubmed	Mouse Dach1 and Dach2 are redundantly required for Müllerian duct development.	DACH2 PAX2	8.42e-05	8	61	2	18395837
Pubmed	Specific ablation of the nidogen-binding site in the laminin gamma1 chain interferes with kidney and lung development.	HSPG2 PAX2	8.42e-05	8	61	2	12015298
Pubmed	Filamin B mutations cause chondrocyte defects in skeletal development.	FLNA COL1A2	8.42e-05	8	61	2	17510210
Pubmed	DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity.	MNX1 MAP3K12	8.42e-05	8	61	2	21893599
Pubmed	POU-III transcription factors (Brn1, Brn2, and Oct6) influence neurogenesis, molecular identity, and migratory destination of upper-layer cells of the cerebral cortex.	POU3F2 POU3F3	8.42e-05	8	61	2	22892427
Pubmed	The Transcription Factor Pou3f1 Sheds Light on the Development and Molecular Diversity of Glutamatergic Cerebellar Nuclear Neurons in the Mouse.	POU3F1 POU3F2	8.42e-05	8	61	2	35935334
Pubmed	Different transcription factors regulate nestin gene expression during P19 cell neural differentiation and central nervous system development.	POU3F2 POU3F3	8.42e-05	8	61	2	19147497
Pubmed	Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue.	CACNA1I CACNA1H	8.42e-05	8	61	2	28330839
Pubmed	3D Mapping Reveals a Complex and Transient Interstitial Matrix During Murine Kidney Development.	HSPG2 COL1A2	8.42e-05	8	61	2	33875569
Pubmed	Neuroepithelial progenitors generate and propagate non-neuronal action potentials across the spinal cord.	CACNA1I CACNA1H	8.42e-05	8	61	2	34478646
Pubmed	Soluble dominant-negative receptor uncovers essential roles for fibroblast growth factors in multi-organ induction and patterning.	NKX2-1 PAX2	8.42e-05	8	61	2	9501086
Pubmed	Intracellular calcium plays an essential role in cardiac development.	CACNA1I CACNA1H	8.42e-05	8	61	2	12761855
Pubmed	Protein profile of exosomes from trabecular meshwork cells.	HSPG2 FLNA COL1A2	8.93e-05	49	61	3	21362503
Pubmed	Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways.	NKX2-1 POU3F1 POU3F2 POU3F3	9.27e-05	134	61	4	19030180
Pubmed	Essential role of the TFIID subunit TAF4 in murine embryogenesis and embryonic stem cell differentiation.	UNCX POU3F2 PAX2	9.49e-05	50	61	3	27026076
Interaction	POU3F4 interactions	POU3F1 POU3F2 POU3F3	4.74e-07	6	59	3	int:POU3F4
Interaction	PAX3 interactions	POU3F2 WWTR1 HDAC10 COL1A2	1.61e-05	52	59	4	int:PAX3
Interaction	POU3F1 interactions	POU3F1 POU3F2 POU3F3	2.23e-05	19	59	3	int:POU3F1
Interaction	POU3F2 interactions	POU3F1 POU3F2 POU3F3	2.62e-05	20	59	3	int:POU3F2
Interaction	POU3F3 interactions	POU3F1 POU3F2 POU3F3	3.53e-05	22	59	3	int:POU3F3
Cytoband	15q25	RHCG POLG	4.84e-05	8	61	2	15q25
Cytoband	11q12.3	INTS5 STX5	1.18e-03	38	61	2	11q12.3
Cytoband	14q11.2	TM9SF1 CHD8 SLC22A17	1.81e-03	180	61	3	14q11.2
Cytoband	2q11.2	FAHD2B FAHD2A	4.18e-03	72	61	2	2q11.2
GeneFamily	POU class homeoboxes and pseudogenes	POU3F1 POU3F2 POU3F3	2.15e-05	23	43	3	523
GeneFamily	Collagens	COL8A2 COL20A1 COL1A2	1.77e-04	46	43	3	490
GeneFamily	Calcium voltage-gated channel subunits	CACNA1I CACNA1H	1.73e-03	26	43	2	253
Coexpression	MEISSNER_BRAIN_HCP_WITH_H3K27ME3	RHCG COL8A2 UNCX MNX1 NKX2-1 PAX2 ONECUT3	3.24e-06	272	61	7	M1938
Coexpression	MEISSNER_BRAIN_HCP_WITH_H3K27ME3	RHCG COL8A2 UNCX MNX1 NKX2-1 PAX2 ONECUT3	4.11e-06	282	61	7	MM822
Coexpression	SHEPARD_BMYB_MORPHOLINO_DN	SOX21 FAHD2A POU3F1 POU3F2 POU3F3 COL1A2	7.59e-06	202	61	6	M11840
Coexpression	SHEPARD_BMYB_TARGETS	SOX21 POU3F1 POU3F2 POU3F3	3.00e-05	76	61	4	M15973
Coexpression	MIKKELSEN_MCV6_HCP_WITH_H3K27ME3	COL8A2 UNCX KCNC4 POU3F3 CACNA1I PAX2 ONECUT3	6.95e-05	438	61	7	M1954
Coexpression	MIKKELSEN_MCV6_HCP_WITH_H3K27ME3	COL8A2 UNCX KCNC4 POU3F3 CACNA1I PAX2 ONECUT3	7.15e-05	440	61	7	MM832
Coexpression	SHEPARD_CRASH_AND_BURN_MUTANT_DN	SOX21 POU3F1 POU3F2 POU3F3 PAX2	8.33e-05	191	61	5	M2148
Coexpression	CHANDRAN_METASTASIS_DN	COL8A2 TM9SF1 AMDHD2 MN1 SLC22A17 AHNAK2	9.31e-05	316	61	6	M11615
Coexpression	GSE27786_LSK_VS_BCELL_DN	SP1 FLNA SYT3 CHD8 HDAC10	1.01e-04	199	61	5	M4744
Coexpression	NABA_COLLAGENS	COL8A2 COL20A1 COL1A2	1.39e-04	43	61	3	MM17060
Coexpression	NABA_COLLAGENS	COL8A2 COL20A1 COL1A2	1.48e-04	44	61	3	M3005
Coexpression	MEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3	UNCX KCNC4 NKX2-1 CACNA1I PAX2 ONECUT3	1.62e-04	350	61	6	M1949
Coexpression	MEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3	UNCX KCNC4 NKX2-1 CACNA1I PAX2 ONECUT3	1.81e-04	357	61	6	MM828
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_top-relative-expression-ranked_100	SOX21 NKX2-1 SCG5 POU3F1 POU3F3	8.87e-06	99	60	5	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_100
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_ASM_(13)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	RHCG FLNA DACH2 MNX1 AHNAK2	5.62e-06	189	60	5	da9ecc0d7b81c1901f30f97bb44112dc85444a66
ToppCell	Mesenchymal_cells-Arteriolar_fibro.\|World / Lineage and Cell class	HSPG2 COL8A2 MN1 AHNAK2 COL1A2	6.38e-06	194	60	5	c1e8923a50b4138a1e4c054c0c17b7f7122aa8a9
ToppCell	15-Trachea-Epithelial-Epithelial\|Trachea / Age, Tissue, Lineage and Cell class	COL20A1 POU3F2 POU3F3 MN1 COL1A2	6.54e-06	195	60	5	9e9283a397f56732a0a5f2e2527f154d4c2dd56a
ToppCell	15-Distal-Mesenchymal-Airway_Smooth_Muscle\|Distal / Age, Tissue, Lineage and Cell class	RHCG FLNA DACH2 SCG5 COL1A2	6.70e-06	196	60	5	0e45817625b96d21a8cc4dfbbd465ee6403b6802
ToppCell	Mesenchymal_cells-Arteriolar_fibro.\|Mesenchymal_cells / Lineage and Cell class	HSPG2 COL8A2 MN1 AHNAK2 COL1A2	6.87e-06	197	60	5	cb321836980e7b4efbb9284c6af7ccd34079d2be
ToppCell	Brain_organoid-organoid_Velasco_nature-6_mon-Neuronal-Immature_CPNs\|6_mon / Sample Type, Dataset, Time_group, and Cell type.	SLF1 POU3F1 POU3F2 POU3F3 MN1	7.04e-06	198	60	5	4e598aab92141e7d32ec963291ddeed14a21beba
ToppCell	18-Distal-Mesenchymal-Airway_Smooth_Muscle\|Distal / Age, Tissue, Lineage and Cell class	RHCG FLNA RPL27A DACH2 SCG5	7.22e-06	199	60	5	9dd130c041beaa319727f9d22b3f45ba0da49487
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Macroglial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RHCG DACH2 EPB41L4B WRAP53	8.31e-06	95	60	4	a09443e527d37adb637a66ca857525dab1c39a9b
ToppCell	TCGA-Brain-Recurrent_Tumor\|TCGA-Brain / Sample_Type by Project: Shred V9	MNX1 PAX2 ONECUT3 COL1A2	4.16e-05	143	60	4	eeb8ce6e051e18b82b74aaf2fc23f0cb87fc96d5
ToppCell	Bronchial_Biopsy-Epithelial-Goblet_1\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	RHCG PRSS3 DACH2 ONECUT3	4.39e-05	145	60	4	e932361734839c14ffa0c1e028dcef9c833f884f
ToppCell	Bronchial_Biopsy-Epithelial-Goblet_1\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	RHCG PRSS3 DACH2 ONECUT3	4.51e-05	146	60	4	a4f2e3ea79e7154873c01739672ec6454547e6a6
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SEL1L RHCG MN1 COL1A2	7.08e-05	164	60	4	d167c7a987b9b35d1e7725c803df4f9cd5380e47
ToppCell	Adult-Mesenchymal-pericyte_cell-D231\|Adult / Lineage, Cell type, age group and donor	KCNC4 MNX1 CACNA1H COL1A2	8.51e-05	172	60	4	858cee96c1c06160863b4adcd7023c0d678bd50f
ToppCell	343B-Lymphocytic-CD4_T-cell-Treg_cell_4\|343B / Donor, Lineage, Cell class and subclass (all cells)	STX5 POLG POU3F1 ZNF513	9.93e-05	179	60	4	c09c3eed43d1aa3b7aa8f3021e6f2737840cde16
ToppCell	facs-Marrow-T-cells-3m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEL1L SYT3 OGFOD2 CACNA1H	1.04e-04	181	60	4	57f0cc749ae8b6a3d77e2af31f9a6e4739c57049
ToppCell	facs-Marrow-T-cells-3m-Hematologic-hematopoietic_stem_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEL1L SYT3 OGFOD2 CACNA1H	1.04e-04	181	60	4	d01b35cc2fc57991a35be6a06cb7351fbabd9a11
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-kidney_collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RHCG EPB41L4B SCG5 POU3F3	1.06e-04	182	60	4	2ef6889321fd0104d277518d130e19143b3af41c
ToppCell	Pericytes-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	KCNC4 CACNA1H MN1 COL1A2	1.06e-04	182	60	4	46c213597445b1f4f09dc367f27702d24b201daf
ToppCell	droplet-Kidney-nan-21m-Epithelial-Epcam____kidney_collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RHCG EPB41L4B SCG5 POU3F3	1.06e-04	182	60	4	fe4fb213dc0ca482b0f94097fe1b0a51fc2690e2
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25-31\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HSPG2 EPB41L4B COL20A1 POU3F1	1.06e-04	182	60	4	a1c0e4090a9e7aa4941a40c817d178de144888b6
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Macroglial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPB41L4B COL20A1 POU3F1 POU3F2	1.06e-04	182	60	4	82ca6d5ed48b4c487ce00b9309255abb8f20b61d
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Macroglial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPB41L4B COL20A1 FAHD2A POU3F1	1.06e-04	182	60	4	c00e503f442d44fbae73c5e2dc85be69e294e67a
ToppCell	droplet-Limb_Muscle-nan-3m-Macroglial-Schwann_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPB41L4B COL20A1 POU3F1 POU3F2	1.08e-04	183	60	4	2cf36ad89584eb9f8b04de52a1b511b7f3527884
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	RHCG FLNA DACH2 MNX1	1.08e-04	183	60	4	e84539978ab4de42e19186aed00f24bb50cbc21f
ToppCell	droplet-Limb_Muscle-nan-3m-Macroglial\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPB41L4B COL20A1 POU3F1 POU3F2	1.08e-04	183	60	4	98fee6838acfaee5e2e449ba088764ec06b8bc57
ToppCell	droplet-Limb_Muscle-nan-3m-Macroglial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPB41L4B COL20A1 POU3F1 POU3F2	1.10e-04	184	60	4	da8d6e7944eb35e6cbea2feb7cbc2894787d723f
ToppCell	wk_20-22-Epithelial-PNS-intermediate_Schwann\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	HSPG2 COL8A2 EPB41L4B POU3F1	1.10e-04	184	60	4	4e3ba64692868563a579902aa9c6f88cab5bce26
ToppCell	droplet-Limb_Muscle-nan-24m-Macroglial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DACH2 COL20A1 POU3F1 SLC22A17	1.15e-04	186	60	4	adba5647a2feaba8e361dc1020d2f2dc4ce36b16
ToppCell	droplet-Limb_Muscle-nan-24m-Macroglial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPB41L4B COL20A1 POU3F1 SLC22A17	1.15e-04	186	60	4	ea936e66ae4b7b40564711fad60ac0137327995f
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	RHCG DACH2 MNX1 SCG5	1.17e-04	187	60	4	387cb27c8a20031cd87381a9e1172f1f62e1488b
ToppCell	droplet-Limb_Muscle-nan-24m-Macroglial\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPB41L4B COL20A1 POU3F1 SLC22A17	1.17e-04	187	60	4	a0bd2b0ec9e73521c245037b1dd51ff8cf24cbf5
ToppCell	droplet-Limb_Muscle-nan-24m-Macroglial-Schwann_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPB41L4B COL20A1 POU3F1 SLC22A17	1.17e-04	187	60	4	f2af79a20438108c814a73f9e24cd986d537237f
ToppCell	droplet-Limb_Muscle-nan-18m-Macroglial-Schwann_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPB41L4B COL20A1 POU3F1 SLC22A17	1.20e-04	188	60	4	8385fd384fc55e3b17802bb6698eb93b2c16d7f2
ToppCell	droplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HSPG2 KCNC4 MN1 COL1A2	1.20e-04	188	60	4	6c6486cae9a8f2f8200598cb4bfd3fd513eb28a3
ToppCell	droplet-Kidney-nan-21m-Epithelial-kidney_collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RHCG EPB41L4B SCG5 POU3F3	1.20e-04	188	60	4	315ce1736e3a84a63a8d5dfa70d411b501cb2532
ToppCell	droplet-Limb_Muscle-nan-18m-Macroglial\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPB41L4B COL20A1 POU3F1 SLC22A17	1.20e-04	188	60	4	cb9d0b48e2fd9cc576132803273b9c0382900944
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	RHCG FLNA DACH2 MNX1	1.20e-04	188	60	4	3004e961d214919e08c7cd5f10c3de5cf85b35a3
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_myocytic\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	RHCG FLNA DACH2 AHNAK2	1.22e-04	189	60	4	b6d5dec55bf352f6ae19d8f488ae70aa10fb9a8f
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_myocytic\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	RHCG FLNA DACH2 MNX1	1.22e-04	189	60	4	f75cebd4c3e54e297557449ba67ccc8d1a2a14f5
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	RHCG FLNA DACH2 SCG5	1.22e-04	189	60	4	0abc7a4900cc9033bc1be69b770ccc54a6bf41b4
ToppCell	droplet-Limb_Muscle-nan-18m-Macroglial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPB41L4B COL20A1 POU3F1 SLC22A17	1.25e-04	190	60	4	e2481bd5166fde2cdc0c3824894f2bccb8294fdd
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-Neuronal-ventral_progenitors_and_neurons_2\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	RPL27A NKX2-1 POU3F1 COL1A2	1.27e-04	191	60	4	509d17d8ee0d028757ce0f2c9b97e5875f06f0ab
ToppCell	COVID-19-kidney-CNT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	RHCG KCNC4 POU3F3 PAX2	1.30e-04	192	60	4	760c6b9628de9693034b00c5025c5c4df94bb2e8
ToppCell	droplet-Kidney-nan-3m-Epithelial-Epcam____kidney_collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RHCG EPB41L4B SCG5 POU3F3	1.33e-04	193	60	4	536b277d90070c4571c592a3c6323b4bf4819f67
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-Epcam____kidney_collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RHCG EPB41L4B SCG5 PAX2	1.33e-04	193	60	4	0208fcd8ea4662f40fc2c072ac220d97823eec12
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-kidney_collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RHCG EPB41L4B SCG5 PAX2	1.33e-04	193	60	4	04d47ba7cc1f19f1ffb18d9e68469e75063697cf
ToppCell	droplet-Kidney-nan-3m-Epithelial-kidney_collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RHCG EPB41L4B SCG5 POU3F3	1.33e-04	193	60	4	0499611c21d283321ef6dd24add154dea48da1b7
ToppCell	wk_20-22-Mesenchymal-Myofibro_&_SMC-Myofibro_2\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	RHCG FLNA DACH2 SCG5	1.33e-04	193	60	4	2f203f6f0c2135acb046c9351a633c3b5b254a46
ToppCell	facs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l1\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	COL8A2 WWTR1 MN1 COL1A2	1.44e-04	197	60	4	3fe665c0277d091290b63f0dd24c0c6536a45309
ToppCell	wk_15-18-Mesenchymal-Myofibro_&_SMC-MYL4+_SMC\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	RHCG FLNA MNX1 AHNAK2	1.44e-04	197	60	4	4797f414330316e2ac2cf7cd2570d991877d7a38
ToppCell	(2)_Fibroblasts-(23)_Fibro-4\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	COL8A2 MN1 AHNAK2 COL1A2	1.44e-04	197	60	4	a183919023a4aca90a06be0e5e89c817b38c5574
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia/MHC-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FLNA TM9SF1 WWTR1 COL1A2	1.46e-04	198	60	4	399760b6b6fef8639ded53b14f251b9fce600e81
ToppCell	(2)_Fibroblasts\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	COL8A2 MN1 AHNAK2 COL1A2	1.49e-04	199	60	4	777423b413376b0d3fbd92ff51dd0133fb54d293
ToppCell	(2)_Fibroblasts-(24)_Fibro-5\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	COL8A2 MN1 AHNAK2 COL1A2	1.49e-04	199	60	4	6c0354f57883330c685a8d9d5d3014ace7eca584
ToppCell	Kidney-Keratinocytes\|Kidney / Skin and Kidney Cells in Lupus Nephritis Patients.	PRSS3 SOX21 POU3F1 AHNAK2	1.52e-04	200	60	4	41d83faa9f45ee7ea2ab19be8ecc6d2c5ac7fe5d
ToppCell	tumor_Lymph_Node_/_Brain-Fibroblasts-Myofibroblasts\|Fibroblasts / Location, Cell class and cell subclass	HSPG2 FLNA WWTR1 COL1A2	1.52e-04	200	60	4	eabb7d4aa92ace7d970bcd3fae2c7cb5400a43b4
ToppCell	MS-Multiple_Sclerosis-Lymphocyte-T/NK-dn_T\|Multiple_Sclerosis / Disease, condition lineage and cell class	FBXO40 SCG5 PPME1 POU3F1	1.52e-04	200	60	4	1aa298dd7172e023adf569c32e49f69fa8d9c7ff
Drug	Levopropoxyphene napsylate [5714-90-9]; Up 200; 7.4uM; MCF7; HT_HG-U133A	SEL1L SP1 HSPG2 FBXO40 STX5 CACNA1I WRAP53	8.85e-07	198	60	7	5503_UP
Drug	LY 294002; Up 200; 10uM; HL60; HT_HG-U133A	STX5 SCG5 POLG WWTR1 SLC22A17 COL1A2	8.95e-06	184	60	6	2696_UP
Drug	15d-PGJ2; Down 200; 10uM; MCF7; HT_HG-U133A	SEL1L VPS13D POLG WWTR1 WRAP53 ZNF839	1.14e-05	192	60	6	6990_DN
Drug	Nizatidine [76963-41-2]; Down 200; 12uM; HL60; HT_HG-U133A	HSPG2 COL8A2 MNX1 WWTR1 PAX2 COL1A2	1.25e-05	195	60	6	3047_DN
Drug	Naringenine [480-41-1]; Down 200; 14.6uM; PC3; HT_HG-U133A	VPS13D POLG SAFB2 ZNF839 MN1 DNAH7	1.25e-05	195	60	6	4597_DN
Drug	Amodiaquin dihydrochloride dihydrate [6398-98-7]; Up 200; 8.6uM; PC3; HT_HG-U133A	SP1 HSPG2 FBXO40 POLG CACNA1I PAX2	1.32e-05	197	60	6	5747_UP
Drug	Cholecalciferol [67-97-0]; Up 200; 10.4uM; HL60; HT_HG-U133A	FBXO40 PRSS3 CACNA1I PAX2 TMEM104 COL1A2	1.36e-05	198	60	6	2436_UP
Drug	SureCN2398996	CACNA1I CACNA1H	2.05e-05	3	60	2	CID010220069
Drug	N-desmethylmethsuximide	CACNA1I CACNA1H	2.05e-05	3	60	2	CID000092154
Drug	1,3-dioxoisoindoline-5-carboxamide	CACNA1I CACNA1H	2.05e-05	3	60	2	CID010679219
Drug	methsuximide	CACNA1I CACNA1H	4.08e-05	4	60	2	CID000006476
Drug	AC1O7G5C	CACNA1I CACNA1H	6.79e-05	5	60	2	CID006603942
Drug	phensuximide	CACNA1I CACNA1H	6.79e-05	5	60	2	CID000006839
Drug	Flunarizine	CACNA1I CACNA1H	6.79e-05	5	60	2	DB04841
Drug	AC1MQ5W8	CACNA1I CACNA1H	1.02e-04	6	60	2	CID003396482
Drug	cerebrocrast	CACNA1I CACNA1H	1.02e-04	6	60	2	CID000159556
Drug	3,4-dihydroquinazoline	CACNA1I CACNA1H	1.02e-04	6	60	2	CID000583065
Drug	troglitazone; Down 200; 10uM; PC3; HT_HG-U133A	SEL1L VPS13D POLG SAFB2 WRAP53	1.41e-04	189	60	5	1232_DN
Drug	LY215840	CACNA1I CACNA1H	1.42e-04	7	60	2	CID000132049
Drug	losigamone	CACNA1I CACNA1H	1.42e-04	7	60	2	CID000060572
Drug	Flumethasone [2135-17-3]; Down 200; 9.8uM; MCF7; HT_HG-U133A	COL8A2 MNX1 POLG CACNA1H SLC22A17	1.63e-04	195	60	5	4734_DN
Drug	Suprofen [40828-46-4]; Up 200; 15.4uM; MCF7; HT_HG-U133A	HSPG2 FBXO40 SOX21 CACNA1H WWTR1	1.63e-04	195	60	5	4123_UP
Drug	cox-2 inhibitor I; Up 200; 10uM; MCF7; HG-U133A	CACNA1I CACNA1H WRAP53 MAP3K12 RHAG	1.63e-04	195	60	5	207_UP
Drug	radicicol; Down 200; 0.1uM; MCF7; HT_HG-U133A	VPS13D POLG POU3F2 CACNA1I MAP3K12	1.67e-04	196	60	5	5947_DN
Drug	Meclocycline sulfosalicylate [73816-42-9]; Down 200; 5.8uM; MCF7; HT_HG-U133A	SP1 VPS13D SAFB2 TMEM104 SLC22A17	1.67e-04	196	60	5	4982_DN
Drug	Roxarsone [121-19-7]; Down 200; 15.2uM; HL60; HT_HG-U133A	SP1 VPS13D STX5 SAFB2 ZNF839	1.67e-04	196	60	5	2950_DN
Drug	Primidone [125-33-7]; Down 200; 18.4uM; HL60; HT_HG-U133A	MNX1 SCG5 AMDHD2 WWTR1 COL1A2	1.71e-04	197	60	5	3065_DN
Drug	Raloxifene hydrochloride [82640-04-8]; Up 200; 7.8uM; PC3; HT_HG-U133A	SEL1L SP1 FBXO40 COL8A2 CACNA1I	1.71e-04	197	60	5	5759_UP
Drug	Butylparaben [94-26-8]; Up 200; 20.6uM; HL60; HT_HG-U133A	SEL1L VPS13D STX5 WWTR1 RHAG	1.71e-04	197	60	5	3069_UP
Drug	Morantel tartrate [26155-31-7]; Up 200; 10.8uM; MCF7; HT_HG-U133A	VPS13D POLG SAFB2 SLC22A17 AHNAK2	1.71e-04	197	60	5	1676_UP
Drug	chlorpromazine hydrochloride; Up 200; 1uM; PC3; HT_HG-U133A	STX5 SOX21 POLG AMDHD2 CACNA1I	1.71e-04	197	60	5	1217_UP
Drug	Oxybenzone [131-57-7]; Up 200; 17.6uM; HL60; HT_HG-U133A	POU3F1 POU3F2 CACNA1I TMEM104 SLC22A17	1.75e-04	198	60	5	3092_UP
Drug	Levonordefrin [829-74-3]; Up 200; 21.8uM; MCF7; HT_HG-U133A	SAFB2 CACNA1H SLC22A17 AHNAK2 COL1A2	1.75e-04	198	60	5	3450_UP
Drug	Nilutamide [63612-50-0]; Up 200; 12.6uM; MCF7; HT_HG-U133A	VPS13D CACNA1I CACNA1H WWTR1 PAX2	1.75e-04	198	60	5	6481_UP
Drug	estradiol, USP; Up 200; 0.01uM; PC3; HT_HG-U133A	VPS13D SOX21 MNX1 POLG CACNA1I	1.75e-04	198	60	5	1241_UP
Drug	Droperidol [548-73-2]; Up 200; 10.6uM; MCF7; HT_HG-U133A	FBXO40 SOX21 NKX2-1 PAX2 COL1A2	1.75e-04	198	60	5	5690_UP
Drug	Benzathine benzylpenicillin [5928-84-7]; Up 200; 4.2uM; MCF7; HT_HG-U133A	HSPG2 FBXO40 SAFB2 CACNA1I AHNAK2	1.79e-04	199	60	5	4140_UP
Drug	estradiol, USP; Down 200; 0.01uM; MCF7; HT_HG-U133A	VPS13D STX5 POLG SAFB2 MAP3K12	1.79e-04	199	60	5	7000_DN
Drug	Biperiden hydrochloride [1235-82-1]; Down 200; 11.4uM; MCF7; HT_HG-U133A	SEL1L SP1 HSPG2 SAFB2 AHNAK2	1.79e-04	199	60	5	5644_DN
Disease	Schwartz-Jampel Syndrome, Type 1	HSPG2 FLNA	4.17e-04	16	56	2	C4551479
Disease	Spondyloepiphyseal Dysplasia	HSPG2 FLNA	4.17e-04	16	56	2	C0038015
Disease	Schwartz-Jampel Syndrome	HSPG2 FLNA	4.17e-04	16	56	2	C0036391
Disease	Melnick-Needles Syndrome	HSPG2 FLNA	4.17e-04	16	56	2	C0025237
Disease	Spondyloepiphyseal Dysplasia Tarda, X-Linked	HSPG2 FLNA	4.17e-04	16	56	2	C3541456
Disease	Van Buchem disease	HSPG2 FLNA	4.72e-04	17	56	2	C0432272
Disease	osteochondrodysplasia (is_implicated_in)	HSPG2 FLNA	5.93e-04	19	56	2	DOID:2256 (is_implicated_in)
Disease	Dyschondroplasias	HSPG2 FLNA	5.93e-04	19	56	2	C0013366
Disease	Osteochondrodysplasias	HSPG2 FLNA	5.93e-04	19	56	2	C0029422
Disease	Multiple Epiphyseal Dysplasia	HSPG2 FLNA	6.58e-04	20	56	2	C0026760
Disease	sciatic neuropathy (biomarker_via_orthology)	KCNC4 CACNA1I CACNA1H	8.93e-04	99	56	3	DOID:11446 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
SGGPQGHRHVVLGSL	CHD8	296	Q9HCK8
LAGHHIKGGPQAELG	CFAP77	91	Q6ZQR2
GGAHEGLQHLGPFGN	SCG5	76	P05408
GIAHAALAGQPGIGG	DACH2	281	Q96NX9
LNHHRGGLAAGLGPA	DMRTA2	351	Q96SC8
VGSGGAGLGAHPGHQ	NKX2-1	306	P43699
GPNGHSHLLKVRAGG	RAVER1	526	Q8IY67
AVLHVHGGGGPRVQV	HSPG2	1946	P98160
GPVLLLLHGGGHSAL	PPME1	76	Q9Y570
GVLHRGGQLHGARPL	OGFOD2	281	Q6N063
GLALGLHPGGAQGGA	MNX1	136	P50219
GSGGAPVLRVGHDHG	PMS2P11	121	Q13670
LAAGGGGAGPGLHHA	POU3F1	176	Q03052
HLVGPHLGLETGNGG	FAHD2A	36	Q96GK7
FVLGGGLHSHPQGAE	HSPA7	336	P48741
SAMHPGHGGVNQLGG	PAX2	11	Q02962
NGLQGLPGIAGHHGD	COL1A2	1026	P08123
LPGIAGHHGDQGAPG	COL1A2	1031	P08123
LVALGPGHGLQGPHA	HDAC10	576	Q969S8
HLVGPHLGLETGNGG	FAHD2B	36	Q6P2I3
QGHPGHQGIPGRVGL	COL20A1	1116	Q9P218
IGGHGLGAGIGPTIQ	FLNA	1651	P21333
NGHLDPSLPLGGHLG	CACNA1I	911	Q9P0X4
IAGLHLPNGGVEGAV	COL8A2	541	P25067
GALHLHLGGAPEGPA	DNAH7	1316	Q8WXX0
HVLQLHEQDAGGPGG	MAP3K12	46	Q12852
GAVGGVDIGLVPHGL	FBXO40	171	Q9UH90
EHGLGQAPGHLSGLS	CACNA1H	666	O95180
AGGGPLLTGGAAVHI	EPB41L4B	61	Q9H329
GAGGGAQSLVHPGLV	POU3F3	246	P20264
GLQHLGLGHNKLLGP	LRRC43	196	Q8N309
PLGGLAAAGAHGPHG	ONECUT3	286	O60422
RKHPGGRGNAGGLHH	RPL27A	26	P46776
QGGLVHGGPVGGLAQ	MN1	586	Q10571
LGRGNLPHIGGGHIP	POLG	221	A0A3B3IS91
HLAAGLGGHPLLGGP	SYT3	116	Q9BQG1
GLHAGAGGGLVPESL	SOX21	116	Q9Y651
DGSPLALLGGHQGGI	WRAP53	356	Q9BUR4
SQPHGIHGTALIGGL	PPP1R8	276	Q12972
LGGLSGPAQRLHMGH	SLC22A17	456	Q8WUG5
QVGLGQLHLHGGRGV	SEL1L	376	Q9UBV2
EGGGEGGPHLAVLHS	INTS5	976	Q6P9B9
HGAQLGLHGAGGDGI	SP1	561	P08047
LGAGGQPAGLHHHGL	POU3F2	201	P20265
LAPNHLGGGAVVLGA	STX5	221	Q13190
LPEGHVLEGAGLKGH	AHNAK2	3211	Q8IVF2
QKVHGHGGAGGPGLS	ZNF513	491	Q8N8E2
GHTHLGLPGARGLGL	STPG3	196	Q8N7X2
LALIRIGHGQGEGHP	TMEM104	251	Q8NE00
HNLHGLPGVVGGLAG	RHAG	331	Q02094
LNLGLHAGGGSGPGL	SLC35A4	231	Q96G79
HSQGHVVPGGGLEGG	SAFB2	911	Q14151
HDVGHLGPLSPAGGG	nan	76	Q5BKY6
GHVEIGKLLLQHGGP	SLF1	886	Q9BQI6
NNLHGIPGIIGGIVG	RHCG	341	Q9UBD6
GGPGHAEAGHLGKVC	ZNF839	646	A8K0R7
GGAQRGGAGLELHPL	PRSS3	36	P35030
LLGTGHGPGVEGVTH	TM9SF1	21	O15321
LLEHPHAQFGGSLGG	UNCX	6	A6NJT0
GGHPGPRLAGGAQHV	WWTR1	71	Q9GZV5
LVAGIHGLAHGIIGG	VPS13D	4146	Q5THJ4
LQRLGPHEGGAGHGA	KCNC4	186	Q03721
GPHGAGVLGLHLEGP	AMDHD2	131	Q9Y303