Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionsodium:bicarbonate symporter activity

SLC4A10 SLC4A7 SLC4A8

6.75e-086313GO:0008510
GeneOntologyMolecularFunctionmonoatomic cation:bicarbonate symporter activity

SLC4A10 SLC4A7 SLC4A8

9.59e-0713313GO:0140410
GeneOntologyMolecularFunctionsodium,bicarbonate:chloride antiporter activity

SLC4A10 SLC4A8

6.99e-063312GO:0140892
GeneOntologyMolecularFunctionsolute:inorganic anion antiporter activity

SLC4A10 SLC4A7 SLC4A8

1.63e-0532313GO:0005452
GeneOntologyMolecularFunctionbicarbonate transmembrane transporter activity

SLC4A10 SLC4A7 SLC4A8

1.63e-0532313GO:0015106
GeneOntologyMolecularFunctionchloride:bicarbonate antiporter activity

SLC4A10 SLC4A8

1.80e-0413312GO:0140900
GeneOntologyMolecularFunctionbicarbonate:monoatomic anion antiporter activity

SLC4A10 SLC4A8

1.80e-0413312GO:0140829
GeneOntologyMolecularFunctionsolute:sodium symporter activity

SLC4A10 SLC4A7 SLC4A8

2.66e-0481313GO:0015370
GeneOntologyMolecularFunctiontau-protein kinase activity

DYRK1A SIK3

5.28e-0422312GO:0050321
GeneOntologyMolecularFunctionsolute:monoatomic cation symporter activity

SLC4A10 SLC4A7 SLC4A8

8.21e-04119313GO:0015294
GeneOntologyMolecularFunctionantiporter activity

SLC4A10 SLC4A7 SLC4A8

1.26e-03138313GO:0015297
GeneOntologyMolecularFunctionsymporter activity

SLC4A10 SLC4A7 SLC4A8

1.60e-03150313GO:0015293
GeneOntologyMolecularFunctionmonoatomic anion transmembrane transporter activity

SLC4A10 SLC4A7 SLC4A8

1.63e-03151313GO:0008509
GeneOntologyMolecularFunctionmetal cation:monoatomic cation antiporter activity

SLC4A10 SLC4A8

2.02e-0343312GO:0140828
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SLC4A10 SLC4A7 SLC4A8

2.33e-03171313GO:0015081
GeneOntologyMolecularFunctioninorganic anion transmembrane transporter activity

SLC4A10 SLC4A7 SLC4A8

2.33e-03171313GO:0015103
GeneOntologyBiologicalProcessbicarbonate transport

SLC4A10 SLC4A7 SLC4A8

2.76e-0538323GO:0015701
DomainANION_EXCHANGER_2

SLC4A10 SLC4A7 SLC4A8

1.30e-077303PS00220
DomainANION_EXCHANGER_1

SLC4A10 SLC4A7 SLC4A8

1.30e-077303PS00219
DomainBand3_cytoplasmic_dom

SLC4A10 SLC4A7 SLC4A8

3.12e-079303IPR013769
DomainBand_3_cyto

SLC4A10 SLC4A7 SLC4A8

3.12e-079303PF07565
Domain-

SLC4A10 SLC4A7 SLC4A8

3.12e-0793033.40.1100.10
DomainPTrfase/Anion_transptr

SLC4A10 SLC4A7 SLC4A8

4.45e-0710303IPR016152
DomainHCO3_cotransp

SLC4A10 SLC4A7 SLC4A8

4.45e-0710303PF00955
DomainHCO3_transpt_euk

SLC4A10 SLC4A7 SLC4A8

4.45e-0710303IPR003020
DomainHCO3_transpt_C

SLC4A10 SLC4A7 SLC4A8

4.45e-0710303IPR011531
DomainNa/HCO3_transpt

SLC4A10 SLC4A8

2.49e-055302IPR003024
DomainAnion_exchange

SLC4A10 SLC4A7

2.49e-055302IPR001717
PathwayREACTOME_BICARBONATE_TRANSPORTERS

SLC4A10 AHCYL2 SLC4A7 SLC4A8

1.35e-0910244M27335
PathwayREACTOME_BICARBONATE_TRANSPORTERS

SLC4A10 AHCYL2 SLC4A7 SLC4A8

1.35e-0910244MM15073
PathwayREACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES

SLC4A10 AHCYL2 SLC4A7 SLC4A8

3.08e-05108244M823
PathwayREACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES

SLC4A10 AHCYL2 SLC4A7 SLC4A8

3.19e-05109244MM15074
PathwayREACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT

SLC4A10 AHCYL2 SLC4A7 SLC4A8

6.45e-04238244MM15076
PathwayREACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT

SLC4A10 AHCYL2 SLC4A7 SLC4A8

7.64e-04249244M5988
Pubmed

Immunocytochemical identification of electroneutral Na⁺-coupled HCO₃⁻ transporters in freshly dissociated mouse medullary raphé neurons.

SLC4A10 SLC4A7 SLC4A8

7.07e-09532323500099
Pubmed

K+-Driven Cl-/HCO3- Exchange Mediated by Slc4a8 and Slc4a10.

SLC4A10 SLC4A8

8.20e-07232238674160
Pubmed

Chronic continuous hypoxia decreases the expression of SLC4A7 (NBCn1) and SLC4A10 (NCBE) in mouse brain.

SLC4A10 SLC4A7

8.20e-07232217928512
Pubmed

The COOH termini of NBC3 and the 56-kDa H+-ATPase subunit are PDZ motifs involved in their interaction.

SLC4A7 SLC4A8

2.46e-06332212444018
Pubmed

Regulation of the human NBC3 Na+/HCO3- cotransporter by carbonic anhydrase II and PKA.

SLC4A7 SLC4A8

2.46e-06332214736710
Pubmed

A SCL4A10 gene product maps selectively to the basolateral plasma membrane of choroid plexus epithelial cells.

SLC4A10 SLC4A7

4.92e-06432214592810
Pubmed

The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3- salvage transporter human Na+-HCO3- cotransport isoform 3.

SLC4A7 SLC4A8

4.92e-06432212403779
Pubmed

Molecular expression of SLC4-derived Na+-dependent anion transporters in selected human tissues.

SLC4A7 SLC4A8

4.92e-06432217715183
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

DYRK1A FBXO11 IRS1 SLC4A7 ZNF467 USP42 NUS1 IQSEC2

1.00e-05120332829180619
Pubmed

Early Hearing Loss upon Disruption of Slc4a10 in C57BL/6 Mice.

SLC4A10 SLC4A7

1.23e-05632231001720
Pubmed

USP42 protects ZNRF3/RNF43 from R-spondin-dependent clearance and inhibits Wnt signalling.

USP42 RNF43

1.72e-05732233786993
Pubmed

Inositol 1,4,5-triphosphate receptor-binding protein released with inositol 1,4,5-triphosphate (IRBIT) associates with components of the mRNA 3' processing machinery in a phosphorylation-dependent manner and inhibits polyadenylation.

CPSF1 AHCYL2

2.94e-05932219224921
Pubmed

Identification of novel Smad2 and Smad3 associated proteins in response to TGF-beta1.

DYRK1A IRS1 SIK3

2.97e-056532318729074
Pubmed

A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network.

AHCYL2 FAM135B

3.67e-051032222228203
Pubmed

Severe neurologic impairment in mice with targeted disruption of the electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5 gene).

SLC4A10 SLC4A7

5.38e-051232221705333
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

DYRK1A IRS1 MTCL1 SLC4A7 SIK3 IQSEC2

1.18e-0486132636931259
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

FBXO11 AHCYL2 MTCL1 USP42 RPL3L PRIM2

2.73e-04100532619615732
Pubmed

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.

U2AF1L4 DYRK1A CPSF1 IRS1 LTBP1 SLC4A7 SIK3

2.91e-04145132730550785
Pubmed

Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.

SLC4A10 MTCL1 SLC4A7 SLC4A8

3.62e-0437132415747579
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

MTCL1 SIK3 ZNF579 USP42 IQSEC2

3.89e-0468932536543142
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

DYRK1A CPSF1 IRS1 ZNF579 ADGRA2 RNF43

4.53e-04110532635748872
Pubmed

Novel gene function revealed by mouse mutagenesis screens for models of age-related disease.

SLC4A10 IRS1

7.57e-044432227534441
InteractionODAPH interactions

LTBP1 AHCYL2 SLC4A7 ZNF579

8.07e-0749304int:ODAPH
Cytoband8q24.23

CPSF1 FAM135B

2.82e-0643228q24.23
GeneFamilySolute carriers

SLC4A10 SLC4A7 SLC4A8

7.73e-03395193752
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

IRS1 LTBP1 MTCL1 RNF43

8.33e-06187314387cb27c8a20031cd87381a9e1172f1f62e1488b
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

IRS1 LTBP1 MTCL1 RNF43

8.69e-061893140abc7a4900cc9033bc1be69b770ccc54a6bf41b4
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

IRS1 LTBP1 MTCL1 SLC4A7

1.09e-05200314dcdaec3ca3a3024dc1b8788c417003f84c2bffdc
Diseaseanemia (implicated_via_orthology)

SLC4A10 SLC4A7 SLC4A8

3.46e-0715283DOID:2355 (implicated_via_orthology)
DiseaseEpilepsy, Cryptogenic

SLC4A10 DYRK1A IQSEC2

6.44e-0582283C0086237
DiseaseAwakening Epilepsy

SLC4A10 DYRK1A IQSEC2

6.44e-0582283C0751111
DiseaseAura

SLC4A10 DYRK1A IQSEC2

6.44e-0582283C0236018
DiseaseEpilepsy

SLC4A10 DYRK1A IQSEC2

1.50e-04109283C0014544
Diseaseresponse to fenofibrate

AHCYL2 FAM135B

1.03e-0350282GO_1901557
Diseaseintellectual disability (implicated_via_orthology)

DYRK1A IRS1

2.31e-0375282DOID:1059 (implicated_via_orthology)
Diseasesoluble triggering receptor expressed on myeloid cells 2 measurement

IRS1 MAP10 RPL3L

2.72e-03296283EFO_0010151
DiseaseNeurodevelopmental Disorders

DYRK1A IQSEC2

3.52e-0393282C1535926
Diseaseverbal-numerical reasoning measurement

SLC4A10 RNF43

6.86e-03131282EFO_0008394

Protein segments in the cluster

PeptideGeneStartEntry
PARRNIHDRGHQGHR

ERVPABLB-1

11

P60509
RFLHLRIHGDVPHHA

CEACAM18

326

A8MTB9
GNLAHRHPNNVHHGR

ADGRA2

1166

Q96PE1
HHHHGQQALGNRTRP

DYRK1A

616

Q13627
HHHLHPVAERRRLHR

MTCL1

26

Q9Y4B5
HLHPQHRRLLHQRQQ

PATL1

356

Q86TB9
HRHRGRFPLHNRVGE

MAP10

156

Q9P2G4
QLHRGELHRDPHGAR

IQSEC2

66

Q5JU85
GGRHHRLALHKPPLH

CPSF1

676

Q10570
FRRRGHLGIFHHHRH

HRCT1

61

Q6UXD1
HRRRPIHHHVGKGPV

LTBP1

741

Q14766
RRHHRHPRGGSCLAA

NUS1

66

Q96E22
RARHTPRAHPGHLHK

IGFBPL1

131

Q8WX77
LAVVKGRRQRHPHHH

NSMF

121

Q6X4W1
GRRQRHPHHHSQPLR

NSMF

126

Q6X4W1
AHRHRGSARLHPPLN

IRS1

356

P35568
LHKALRENHHLRHGG

PRIM2

291

P49643
HGNPIIRRNHIHHGR

FBXO11

441

Q86XK2
HHRPRLFHRHRHQSP

LCE2A

71

Q5TA79
RTLGLHFHPRNGLHH

FAM135B

136

Q49AJ0
PHHQHQRHRDGGEAL

AHCYL2

91

Q96HN2
RRRHRHRGHKHHHRR

SLC4A7

56

Q9Y6M7
HGHLGFLPHKRSHRH

RPL3L

11

Q92901
RLHGRIIKSHHLHPF

OR7E24

321

Q6IFN5
GRRLHLIRQHPGHAH

RNF43

336

Q68DV7
PSVHEHHRPRALQRH

SIK3

1201

Q9Y2K2
HRHHRTHGQKHRRRG

SLC4A8

61

Q2Y0W8
AGLHERPHKDHNRGR

USP42

1086

Q9H9J4
LGGRKSHRRHRHRGH

SLC4A10

56

Q6U841
HRGHHCPHLHPVLRR

nan

21

Q5BKY6
PRFHTGHHPRERNHR

U2AF1L4

196

Q8WU68
GHLRNHQRGHTGERP

ZNF418

411

Q8TF45
FRRPAHLSRHLRGHG

ZNF579

81

Q8NAF0
SHGQHLARHPRVHTG

ZNF467

441

Q7Z7K2
HLGRHQAVHTGSRPH

ZNF467

501

Q7Z7K2