Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ubiquitin-like ligase-substrate adaptor activity	PRAMEF5 PRAMEF9 PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF11 PRAMEF6	1.75e-09	82	52	7	GO:1990756
GeneOntologyMolecularFunction	enzyme-substrate adaptor activity	PRAMEF5 PRAMEF9 PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF11 PRAMEF6	4.95e-09	95	52	7	GO:0140767
GeneOntologyMolecularFunction	nuclear retinoic acid receptor binding	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF11 PRAMEF6	6.09e-09	55	52	6	GO:0042974
GeneOntologyMolecularFunction	nuclear receptor binding	PRAMEF5 PRAMEF15 TRIM68 PRAMEF4 PRAMEF27 PRAMEF11 PRAMEF6	5.29e-07	187	52	7	GO:0016922
GeneOntologyMolecularFunction	protein-macromolecule adaptor activity	LDLRAP1 KSR1 KMT2C PRAMEF5 PRAMEF9 ZNF493 CIDEC PRAMEF15 APBB1 NAPA PRAMEF4 PRAMEF27 PRAMEF11 PRAMEF6	1.02e-06	1160	52	14	GO:0030674
GeneOntologyMolecularFunction	molecular adaptor activity	LDLRAP1 KSR1 KMT2C PRAMEF5 PRAMEF9 ZNF493 CIDEC PRAMEF15 APBB1 NAPA PRAMEF4 PRAMEF27 PRAMEF11 PRAMEF6	6.36e-06	1356	52	14	GO:0060090
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	ZNF585A ZNF493 ZNF780A RREB1 CLOCK PRDM15 ZNF574 ZNF585B	9.24e-05	560	52	8	GO:0001228
GeneOntologyMolecularFunction	RNA polymerase II-specific DNA-binding transcription factor binding	PRAMEF5 PRAMEF15 TRIM68 PRAMEF4 PRAMEF27 PRAMEF11 PRAMEF6	9.80e-05	417	52	7	GO:0061629
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	ZNF585A ZNF493 ZNF780A RREB1 CLOCK PRDM15 ZNF574 ZNF585B	9.95e-05	566	52	8	GO:0001216
GeneOntologyMolecularFunction	DNA-binding transcription factor binding	PRAMEF5 PRAMEF15 APBB1 TRIM68 PRAMEF4 PRAMEF27 PRAMEF11 PRAMEF6	1.21e-04	582	52	8	GO:0140297
GeneOntologyMolecularFunction	transcription factor binding	PRAMEF5 PRAMEF15 APBB1 TRIM68 PRAMEF4 CLOCK PRAMEF27 PRAMEF11 PRAMEF6	1.26e-04	753	52	9	GO:0008134
GeneOntologyBiologicalProcess	blastocyst formation	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	1.69e-06	78	53	5	GO:0001825
GeneOntologyBiologicalProcess	oocyte development	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	5.50e-06	99	53	5	GO:0048599
GeneOntologyBiologicalProcess	oocyte differentiation	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	6.68e-06	103	53	5	GO:0009994
GeneOntologyBiologicalProcess	negative regulation of DNA-templated transcription	PRAMEF25 PRAMEF5 PRAMEF9 ZNF493 WNT11 PRAMEF15 ZBTB21 APBB1 PRAMEF4 RREB1 CLOCK PRAMEF27 PRAMEF11 PRAMEF6	8.00e-06	1399	53	14	GO:0045892
GeneOntologyBiologicalProcess	somatic stem cell population maintenance	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	8.42e-06	108	53	5	GO:0035019
GeneOntologyBiologicalProcess	negative regulation of RNA biosynthetic process	PRAMEF25 PRAMEF5 PRAMEF9 ZNF493 WNT11 PRAMEF15 ZBTB21 APBB1 PRAMEF4 RREB1 CLOCK PRAMEF27 PRAMEF11 PRAMEF6	8.97e-06	1413	53	14	GO:1902679
GeneOntologyBiologicalProcess	regulation of MAPK cascade	KSR1 MFAP3 TRAF4 SFRP5 PRAMEF5 PRAMEF15 PRAMEF4 PRDM15 PRAMEF11 PRAMEF6	3.66e-05	815	53	10	GO:0043408
GeneOntologyBiologicalProcess	oogenesis	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	4.97e-05	156	53	5	GO:0048477
GeneOntologyBiologicalProcess	negative regulation of cell differentiation	PRAMEF25 PRAMEF5 PRAMEF9 IPO7 PRAMEF15 APBB1 PRAMEF4 PRAMEF27 PRAMEF11 PRAMEF6	6.65e-05	875	53	10	GO:0045596
GeneOntologyBiologicalProcess	blastocyst development	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	9.53e-05	179	53	5	GO:0001824
GeneOntologyBiologicalProcess	MAPK cascade	KSR1 MFAP3 TRAF4 SFRP5 PRAMEF5 PRAMEF15 PRAMEF4 PRDM15 PRAMEF11 PRAMEF6	1.10e-04	930	53	10	GO:0000165
GeneOntologyBiologicalProcess	convergent extension involved in axis elongation	SFRP5 WNT11	1.80e-04	8	53	2	GO:0060028
GeneOntologyBiologicalProcess	positive regulation of cell population proliferation	LDLRAP1 KMT2C PRAMEF25 PRAMEF5 PRAMEF9 PRAMEF15 PRAMEF4 RREB1 PRAMEF27 PRAMEF11 PRAMEF6	1.83e-04	1190	53	11	GO:0008284
GeneOntologyBiologicalProcess	negative regulation of developmental process	PRAMEF25 PRAMEF5 PRAMEF9 IPO7 WNT11 PRAMEF15 APBB1 PRAMEF4 PRAMEF27 PRAMEF11 PRAMEF6	2.27e-04	1220	53	11	GO:0051093
GeneOntologyBiologicalProcess	negative regulation of non-canonical Wnt signaling pathway	SFRP5 RNF213	2.31e-04	9	53	2	GO:2000051
GeneOntologyBiologicalProcess	female gamete generation	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	2.66e-04	223	53	5	GO:0007292
GeneOntologyBiologicalProcess	stem cell population maintenance	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	3.52e-04	237	53	5	GO:0019827
GeneOntologyBiologicalProcess	maintenance of cell number	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	3.87e-04	242	53	5	GO:0098727
GeneOntologyBiologicalProcess	regulation of ERK1 and ERK2 cascade	MFAP3 PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	4.45e-04	385	53	6	GO:0070372
GeneOntologyBiologicalProcess	ERK1 and ERK2 cascade	MFAP3 PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	6.86e-04	418	53	6	GO:0070371
GeneOntologyCellularComponent	Cul2-RING ubiquitin ligase complex	PRAMEF5 PRAMEF9 PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF11 PRAMEF6	2.60e-11	47	53	7	GO:0031462
GeneOntologyCellularComponent	cullin-RING ubiquitin ligase complex	PRAMEF5 PRAMEF9 PRAMEF15 FBXL12 PRAMEF4 PRAMEF27 PRAMEF11 PRAMEF6	5.87e-08	212	53	8	GO:0031461
GeneOntologyCellularComponent	ubiquitin ligase complex	PRAMEF5 PRAMEF9 PRAMEF15 FBXL12 PRAMEF4 PRAMEF27 PRAMEF11 PRAMEF6	2.73e-06	352	53	8	GO:0000151
GeneOntologyCellularComponent	acrosomal vesicle	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	1.73e-04	206	53	5	GO:0001669
GeneOntologyCellularComponent	transferase complex	KMT2C PRAMEF5 PRAMEF9 PRAMEF15 FBXL12 PRAMEF4 PRAMEF27 PRAMEF11 PRAMEF6	6.42e-04	963	53	9	GO:1990234
GeneOntologyCellularComponent	motile cilium	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	2.02e-03	355	53	5	GO:0031514
MousePheno	abnormal spermatogonia proliferation	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF11 PRAMEF6	1.87e-09	47	36	6	MP:0002685
MousePheno	abnormal jejunum morphology	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	5.95e-08	41	36	5	MP:0004002
MousePheno	abnormal duodenum morphology	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	5.80e-07	64	36	5	MP:0003271
MousePheno	increased kidney weight	PRAMEF5 PRAMEF15 PRAMEF4 LYST PRAMEF11 PRAMEF6	1.69e-06	145	36	6	MP:0003917
MousePheno	abnormal circulating amylase level	PRAMEF5 PRAMEF15 PRAMEF4 IZUMO1R PRAMEF11 PRAMEF6	2.59e-06	156	36	6	MP:0008804
MousePheno	abnormal cecum morphology	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	5.10e-06	99	36	5	MP:0000494
MousePheno	increased male germ cell apoptosis	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF11 PRAMEF6	7.84e-06	189	36	6	MP:0014052
MousePheno	enlarged urinary bladder	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	1.11e-05	116	36	5	MP:0011874
MousePheno	increased circulating amylase level	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	1.25e-05	119	36	5	MP:0008806
MousePheno	abnormal kidney weight	PRAMEF5 PRAMEF15 PRAMEF4 LYST PRAMEF11 PRAMEF6	1.36e-05	208	36	6	MP:0002707
MousePheno	abnormal male germ cell apoptosis	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF11 PRAMEF6	2.77e-05	236	36	6	MP:0008280
MousePheno	cataract	PRAMEF5 PRAMEF15 PRAMEF4 MYO15A PRAMEF27 PRAMEF11 PRAMEF6 VCPIP1	3.03e-05	497	36	8	MP:0001304
MousePheno	azoospermia	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF11 PRAMEF6	3.34e-05	244	36	6	MP:0005159
MousePheno	abnormal male germ cell physiology	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF11 PRAMEF6	3.34e-05	244	36	6	MP:0020362
MousePheno	abnormal pancreas morphology	PRAMEF5 PRAMEF15 PRAMEF4 CLOCK SYT13 PRAMEF11 PRAMEF6	3.51e-05	367	36	7	MP:0001944
MousePheno	abnormal urinary bladder morphology	PRAMEF5 IPO7 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	3.58e-05	247	36	6	MP:0000538
MousePheno	absent gametes	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF11 PRAMEF6	4.37e-05	256	36	6	MP:0001117
MousePheno	abnormal lens morphology	PRAMEF5 PRAMEF15 NAPA PRAMEF4 MYO15A PRAMEF27 PRAMEF11 PRAMEF6 VCPIP1	5.17e-05	699	36	9	MP:0001303
MousePheno	abnormal germ cell physiology	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF11 PRAMEF6	5.52e-05	267	36	6	MP:0020363
MousePheno	abnormal tail morphology	TRAF4 PRAMEF5 PRAMEF15 PRAMEF4 LYST PRAMEF11 PRAMEF6	6.36e-05	403	36	7	MP:0002111
MousePheno	abnormal vitreous body morphology	PRAMEF5 CIDEC PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF11 PRAMEF6	9.42e-05	429	36	7	MP:0002699
MousePheno	abnormal small intestine morphology	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	1.09e-04	187	36	5	MP:0000496
MousePheno	abnormal exploration in a new environment	PRAMEF5 IPO7 HTR4 PRAMEF15 PRAMEF4 CLOCK PRAMEF11 PRAMEF6	1.93e-04	647	36	8	MP:0013189
MousePheno	enlarged kidney	PRAMEF5 PRAMEF15 PRAMEF4 LYST PRAMEF11 PRAMEF6	2.59e-04	354	36	6	MP:0003068
MousePheno	abnormal ear physiology	PRAMEF5 CIDEC PRAMEF15 PRAMEF4 MYO15A LYST PRAMEF11 PRAMEF6	2.82e-04	684	36	8	MP:0003878
MousePheno	abnormal response to new environment	PRAMEF5 IPO7 HTR4 PRAMEF15 PRAMEF4 CLOCK PRAMEF11 PRAMEF6	2.90e-04	687	36	8	MP:0001413
MousePheno	decreased testis weight	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF11 PRAMEF6	3.28e-04	370	36	6	MP:0004852
MousePheno	abnormal hair cycle	KSR1 CLOCK LYST	3.75e-04	55	36	3	MP:0000427
MousePheno	abnormal anterior eye segment morphology	PRAMEF5 PRAMEF15 NAPA PRAMEF4 MYO15A LYST PRAMEF27 PRAMEF11 PRAMEF6 VCPIP1	3.78e-04	1117	36	10	MP:0005193
MousePheno	abnormal stomach morphology	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	4.06e-04	248	36	5	MP:0000470
MousePheno	abnormal testis weight	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF11 PRAMEF6	4.41e-04	391	36	6	MP:0004850
MousePheno	abnormal auditory brainstem response	PRAMEF5 CIDEC PRAMEF15 PRAMEF4 MYO15A PRAMEF11 PRAMEF6	5.72e-04	576	36	7	MP:0004738
MousePheno	abnormal large intestine morphology	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	6.61e-04	276	36	5	MP:0000489
MousePheno	small kidney	PRAMEF5 WNT11 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	6.85e-04	425	36	6	MP:0002989
MousePheno	abnormal hearing electrophysiology	PRAMEF5 CIDEC PRAMEF15 PRAMEF4 MYO15A PRAMEF11 PRAMEF6	6.87e-04	594	36	7	MP:0006335
MousePheno	abnormal response to novelty	PRAMEF5 IPO7 HTR4 PRAMEF15 PRAMEF4 CLOCK PRAMEF11 PRAMEF6	7.20e-04	787	36	8	MP:0003107
MousePheno	abnormal skin morphology	KSR1 PRAMEF5 IPO7 PRAMEF15 NAPA PRAMEF4 CLOCK LYST PRAMEF27 PRAMEF11 PRAMEF6	7.67e-04	1455	36	11	MP:0002060
MousePheno	abnormal learning/memory/conditioning	KSR1 PRAMEF5 IPO7 HTR4 PRAMEF15 APBB1 PRAMEF4 CLOCK PRAMEF11 PRAMEF6	8.60e-04	1239	36	10	MP:0002063
MousePheno	abnormal cognition	KSR1 PRAMEF5 IPO7 HTR4 PRAMEF15 APBB1 PRAMEF4 CLOCK PRAMEF11 PRAMEF6	8.98e-04	1246	36	10	MP:0014114
MousePheno	abnormal hearing physiology	PRAMEF5 CIDEC PRAMEF15 PRAMEF4 MYO15A PRAMEF11 PRAMEF6	1.10e-03	643	36	7	MP:0001963
MousePheno	abnormal seminal vesicle morphology	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	1.26e-03	319	36	5	MP:0002059
MousePheno	enlarged lymph nodes	PRAMEF5 IPO7 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	1.70e-03	507	36	6	MP:0000702
MousePheno	decreased exploration in new environment	PRAMEF5 HTR4 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	1.76e-03	510	36	6	MP:0001417
MousePheno	hearing/vestibular/ear phenotype	PRAMEF5 CIDEC PRAMEF15 PRAMEF4 MYO15A LYST PRAMEF11 PRAMEF6	1.78e-03	905	36	8	MP:0005377
MousePheno	abnormal kidney size	PRAMEF5 WNT11 PRAMEF15 PRAMEF4 LYST PRAMEF11 PRAMEF6	2.01e-03	714	36	7	MP:0002706
MousePheno	abnormal male accessory sex gland morphology	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	2.10e-03	358	36	5	MP:0013330
Domain	PRAME_family	PRAMEF25 PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF6	7.13e-12	19	50	6	IPR026271
Domain	-	PRAMEF25 PRAMEF5 PRAMEF15 FBXL12 PRAMEF4 PRAMEF27 PRAMEF6	2.20e-05	321	50	7	3.80.10.10
Domain	L_dom-like	PRAMEF25 PRAMEF5 PRAMEF15 FBXL12 PRAMEF4 PRAMEF27 PRAMEF6	2.52e-05	328	50	7	IPR032675
Domain	-	ZNF585A ZNF493 ZNF780A ZBTB21 RREB1 PRDM15 ZNF461 ZNF574 ZNF585B	6.93e-05	679	50	9	3.30.160.60
Domain	zf-C2H2	ZNF585A ZNF493 ZNF780A ZBTB21 RREB1 PRDM15 ZNF461 ZNF574 ZNF585B	8.10e-05	693	50	9	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF585A ZNF493 ZNF780A ZBTB21 RREB1 PRDM15 ZNF461 ZNF574 ZNF585B	8.19e-05	694	50	9	IPR013087
Domain	ZINC_FINGER_C2H2_2	ZNF585A ZNF493 ZNF780A ZBTB21 RREB1 PRDM15 ZNF461 ZNF574 ZNF585B	1.89e-04	775	50	9	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF585A ZNF493 ZNF780A ZBTB21 RREB1 PRDM15 ZNF461 ZNF574 ZNF585B	1.93e-04	777	50	9	PS00028
Domain	Znf_C2H2-like	ZNF585A ZNF493 ZNF780A ZBTB21 RREB1 PRDM15 ZNF461 ZNF574 ZNF585B	2.31e-04	796	50	9	IPR015880
Domain	Znf_C2H2	ZNF585A ZNF493 ZNF780A ZBTB21 RREB1 PRDM15 ZNF461 ZNF574 ZNF585B	2.51e-04	805	50	9	IPR007087
Domain	ZnF_C2H2	ZNF585A ZNF493 ZNF780A ZBTB21 RREB1 PRDM15 ZNF461 ZNF574 ZNF585B	2.58e-04	808	50	9	SM00355
Domain	C1	KSR1 KMT2C CDC42BPA	7.02e-04	65	50	3	SM00109
Domain	PE/DAG-bd	KSR1 KMT2C CDC42BPA	7.34e-04	66	50	3	IPR002219
Domain	ZF_RING_2	KMT2C TRAF4 RNF213 ZSWIM2 TRIM68	1.18e-03	298	50	5	PS50089
Domain	-	KMT2C TRAF4 PHF3 RNF213 ZSWIM2 TRIM68	1.21e-03	449	50	6	3.30.40.10
Domain	RING	KMT2C TRAF4 RNF213 ZSWIM2 TRIM68	1.31e-03	305	50	5	SM00184
Domain	Znf_RING/FYVE/PHD	KMT2C TRAF4 PHF3 RNF213 ZSWIM2 TRIM68	1.36e-03	459	50	6	IPR013083
Domain	zf-C2H2_6	ZNF493 ZNF780A RREB1 ZNF461 ZNF574	1.48e-03	314	50	5	PF13912
Domain	Znf_RING	KMT2C TRAF4 RNF213 ZSWIM2 TRIM68	1.75e-03	326	50	5	IPR001841
Domain	PID	LDLRAP1 APBB1	2.54e-03	28	50	2	PF00640
Domain	zf-C3HC4	TRAF4 RNF213 ZSWIM2 TRIM68	2.96e-03	223	50	4	PF00097
Domain	PID	LDLRAP1 APBB1	3.31e-03	32	50	2	PS01179
Pubmed	Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF11 PRAMEF6	3.56e-13	20	53	6	26694250
Pubmed	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF11 PRAMEF6	6.84e-13	22	53	6	31729367
Pubmed	MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF11 PRAMEF6	1.62e-12	25	53	6	37451217
Pubmed	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF11 PRAMEF6	3.43e-12	28	53	6	25089626
Pubmed	Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF11 PRAMEF6	1.47e-11	35	53	6	19389355
Pubmed	Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	4.13e-11	17	53	5	23565261
Pubmed	Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	4.13e-11	17	53	5	37781892
Pubmed	Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	5.71e-11	18	53	5	29731491
Pubmed	The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	5.71e-11	18	53	5	23894331
Pubmed	Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	5.71e-11	18	53	5	14675769
Pubmed	Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	5.71e-11	18	53	5	12890732
Pubmed	Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	5.71e-11	18	53	5	39181896
Pubmed	Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	7.75e-11	19	53	5	28604677
Pubmed	Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	1.03e-10	20	53	5	16580637
Pubmed	Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	1.03e-10	20	53	5	21425410
Pubmed	Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	2.23e-10	23	53	5	19480014
Pubmed	Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	3.51e-10	25	53	5	12620990
Pubmed	Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	4.35e-10	26	53	5	18500982
Pubmed	Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	9.37e-10	30	53	5	38786026
Pubmed	LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	1.32e-09	32	53	5	37889087
Pubmed	Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells.	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	8.85e-09	46	53	5	17287250
Pubmed	DUX is a non-essential synchronizer of zygotic genome activation.	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	1.36e-08	50	53	5	31806660
Pubmed	ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation.	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	2.92e-08	58	53	5	31598710
Pubmed	An abundance of X-linked genes expressed in spermatogonia.	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	3.18e-08	59	53	5	11279525
Pubmed	A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.	PRAMEF5 CDC40 ADAM5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	9.63e-07	347	53	7	16033648
Pubmed	Iron-inhibited autophagy via transcription factor ZFP27 in Parkinson's disease.	ZNF585A ZNF585B	2.28e-06	2	53	2	37668106
Pubmed	Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.	PRAMEF5 IPO7 PRAMEF15 PRAMEF4 MYO15A PRAMEF11 PRAMEF6	2.30e-05	564	53	7	21565611
Pubmed	The DNA sequence and biological annotation of human chromosome 1.	LDLRAP1 PRAMEF25 PRAMEF5 PRAMEF9 CDC42BPA PRAMEF4 LYST PRAMEF11 PRAMEF6	2.34e-05	1031	53	9	16710414
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	KMT2C MFAP3 PRAMEF5 EML5 ZNF780A PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	3.47e-05	1084	53	9	11544199
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	IPO7 ZNF780A PHF3 DHX37 ZBTB21 RREB1 PRDM15	3.70e-05	608	53	7	36089195
Pubmed	Deterministic and stochastic allele specific gene expression in single mouse blastomeres.	SFRP5 PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	4.48e-05	424	53	6	21731673
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	KSR1 CDC42BPA PHF3 ZBTB21 APBB1 TRIM68 LYST VCPIP1	4.52e-05	861	53	8	36931259
Pubmed	Ts65Dn -- localization of the translocation breakpoint and trisomic gene content in a mouse model for Down syndrome.	ZBTB21 PRDM15	4.76e-05	7	53	2	11528125
Pubmed	Specific and ubiquitous expression of different Zn finger protein genes in the mouse.	ZNF585A ZNF585B	4.76e-05	7	53	2	3143103
Pubmed	SELENOPROTEINS. CRL2 aids elimination of truncated selenoproteins produced by failed UGA/Sec decoding.	PRAMEF9 PRAMEF6	4.76e-05	7	53	2	26138980
Pubmed	Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.	ZNF585A ZNF493 ZNF585B	5.86e-05	49	53	3	9630514
Pubmed	Maternal microRNAs are essential for mouse zygotic development.	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	6.06e-05	273	53	5	17369397
Pubmed	Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo.	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	1.39e-04	326	53	5	17015433
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	KMT2C CDC42BPA ZBTB21 FASTKD2 CLOCK SYT13	1.51e-04	529	53	6	14621295
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	2.29e-04	363	53	5	14691545
Pubmed	Id2 controls specification of Lgr5+ intestinal stem cell progenitors during gut development.	SFRP5 WNT11	2.36e-04	15	53	2	28077488
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	KSR1 EML5 ZBTB21 RNF213 RREB1 ANKRD52 ZNF461 ZNF574	2.70e-04	1116	53	8	31753913
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	KMT2C PHF3 RNF213 VCPIP1	2.89e-04	208	53	4	33230847
Pubmed	A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry Breaking.	SFRP5 WNT11	3.05e-04	17	53	2	28292423
Pubmed	Evolutionary breakpoints on human chromosome 21.	ZBTB21 PRDM15	4.25e-04	20	53	2	11707078
Pubmed	Primary cilia in murine palatal rugae development.	SFRP5 WNT11	5.65e-04	23	53	2	31226309
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	CDC42BPA EML5 CLIC3 NAPA RREB1 MYO15A SLC36A2	8.50e-04	1016	53	7	19056867
Pubmed	Expression of all Wnt genes and their secreted antagonists during mouse blastocyst and postimplantation development.	SFRP5 WNT11	9.64e-04	30	53	2	15880404
Pubmed	Comprehensive expression analysis of all Wnt genes and their major secreted antagonists during mouse limb development and cartilage differentiation.	SFRP5 WNT11	1.31e-03	35	53	2	19185060
Interaction	PRAMEF4 interactions	PRAMEF5 PRAMEF9 PRAMEF4	1.19e-08	3	47	3	int:PRAMEF4
Interaction	PRAMEF5 interactions	PRAMEF5 PRAMEF15 PRAMEF4	6.60e-07	8	47	3	int:PRAMEF5
Interaction	PRAMEF15 interactions	PRAMEF5 PRAMEF15	5.32e-06	2	47	2	int:PRAMEF15
Cytoband	1p36.21	PRAMEF25 PRAMEF5 PRAMEF9 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	9.53e-13	63	53	7	1p36.21
Cytoband	Ensembl 112 genes in cytogenetic band chr1p36	LDLRAP1 PRAMEF25 PRAMEF5 PRAMEF9 PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF11 PRAMEF6	8.17e-08	681	53	9	chr1p36
Cytoband	19q13.12	ZNF585A ZNF461 ZNF585B	8.19e-05	72	53	3	19q13.12
Cytoband	11q21	IZUMO1R JRKL	1.20e-03	44	53	2	11q21
Cytoband	Ensembl 112 genes in cytogenetic band chr11q21	IZUMO1R JRKL	2.44e-03	63	53	2	chr11q21
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF585A ZNF780A NAPA ZNF461 ZNF574 ZNF585B	2.45e-03	1192	53	6	chr19q13
GeneFamily	PRAME family	PRAMEF25 PRAMEF5 PRAMEF9 PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF11 PRAMEF6	6.59e-16	24	46	8	686
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF585A ZNF493 ZNF780A ZBTB21 RREB1 PRDM15 ZNF461 ZNF574 ZNF585B	6.88e-05	718	46	9	28
Coexpression	DESCARTES_ORGANOGENESIS_SCHWANN_CELL_PRECURSOR	SFRP5 PRAMEF5 PRAMEF15 PRAMEF4 PDE7B PRAMEF11 PRAMEF6	9.58e-10	98	52	7	MM3656
Coexpression	KINNEY_DNMT1_METHYLATION_TARGETS	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	6.72e-09	34	52	5	MM955
Coexpression	KOHOUTEK_CCNT2_TARGETS	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF11 PRAMEF6	1.31e-08	81	52	6	MM938
Coexpression	MORI_SMALL_PRE_BII_LYMPHOCYTE_UP	PRAMEF5 PRAMEF15 PRAMEF4 CLOCK PRAMEF11 PRAMEF6	4.15e-08	98	52	6	MM592
Coexpression	MIKKELSEN_NPC_ICP_WITH_H3K4ME3	PRAMEF5 ZNF585A ZNF493 PRAMEF15 ZSWIM2 FASTKD2 PRAMEF4 PRAMEF11 PRAMEF6 ZNF585B	4.26e-08	497	52	10	MM863
Coexpression	MEISSNER_BRAIN_HCP_WITH_H3_UNMETHYLATED	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	9.77e-08	57	52	5	MM1262
Coexpression	INGRAM_SHH_TARGETS_UP	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF11 PRAMEF6	6.55e-07	156	52	6	MM550
Coexpression	HUANG_GATA2_TARGETS_DN	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	1.49e-06	98	52	5	MM942
Coexpression	BYSTRYKH_HEMATOPOIESIS_STEM_CELL_AND_BRAIN_QTL_TRANS	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6 ZNF574	1.51e-06	180	52	6	MM612
Coexpression	MIKKELSEN_ES_ICP_WITH_H3K4ME3	PRAMEF5 ZNF585A ZNF493 PRAMEF15 FASTKD2 PRAMEF4 PRAMEF27 PRAMEF11 PRAMEF6 ZNF585B	3.55e-06	807	52	10	MM855
Coexpression	YAMAZAKI_TCEB3_TARGETS_DN	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF11 PRAMEF6	6.53e-06	232	52	6	MM1019
Coexpression	SANSOM_APC_TARGETS	PRAMEF5 ZNF780A PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	8.91e-06	245	52	6	MM735
Coexpression	NIKOLSKY_BREAST_CANCER_19Q13.1_AMPLICON	ZNF585A ZNF461 ZNF585B	1.10e-05	22	52	3	M8692
Coexpression	GSE14415_ACT_TCONV_VS_ACT_NATURAL_TREG_UP	LDLRAP1 EML5 RNF213 RREB1 IZUMO1R	2.32e-05	172	52	5	M2945
Coexpression	YAUCH_HEDGEHOG_SIGNALING_PARACRINE_DN	PRAMEF5 ZNF493 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	3.30e-05	309	52	6	MM1244
Coexpression	MIKKELSEN_MEF_HCP_WITH_H3_UNMETHYLATED	PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	1.67e-04	261	52	5	MM1277
Coexpression	KUMAR_TARGETS_OF_MLL_AF9_FUSION	TRAF4 PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	3.01e-04	463	52	6	MM1011
Coexpression	GSE13547_CTRL_VS_ANTI_IGM_STIM_ZFX_KO_BCELL_12H_DN	LDLRAP1 EML5 FBXL12 IZUMO1R	3.02e-04	162	52	4	M7002
ToppCell	TCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Monophasic_Synovial_Sarcoma-5\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	PRAMEF5 PRAMEF9 PRAMEF15 PRAMEF4 PRAMEF11 PRAMEF6	1.41e-09	93	53	6	3e05ea0f8f4a7cdb78a596f47d563dc3c94d4d8e
Disease	cerebral cavernous malformation (implicated_via_orthology)	CDC42BPA RNF213	1.13e-04	11	43	2	DOID:0060669 (implicated_via_orthology)
Disease	complement factor H-related protein 5 measurement	ADAM5 CFHR5	1.72e-03	42	43	2	EFO_0008098
Disease	eye morphology measurement	SFRP5 ADAM5 PDE7B	3.95e-03	218	43	3	EFO_0007858
Disease	lung adenocarcinoma (is_marker_for)	KMT2C TRAF4	6.86e-03	85	43	2	DOID:3910 (is_marker_for)
Disease	smoking status measurement, chronic obstructive pulmonary disease	HTR4 RREB1	7.33e-03	88	43	2	EFO_0000341, EFO_0006527
Disease	age-related macular degeneration	CFHR5 RREB1	7.50e-03	89	43	2	EFO_0001365
Disease	Ischemic stroke, coronary artery disease	HTR4 RNF213	7.99e-03	92	43	2	EFO_0001645, HP_0002140

Protein segments in the cluster

Peptide	Gene	Start	Entry
VTCLCRHMHPKKGLL	SYT13	26	Q7L8C5
MHCKHVRFLMNLKLC	ADAM5	341	Q6NVV9
HCPSCQRLFMVLLLK	CLIC3	21	O95833
MLKCHVFRCEAPAKN	APBB1	476	O00213
LACSKGHEKCALMIL	ANKRD52	931	Q8NB46
LECHAFLCTKRKMAQ	LDLRAP1	141	Q5SW96
RGLQMKCVFCHKTGA	KMT2C	4456	Q8NEZ4
LLMPGCRKHFIQAIC	IZUMO1R	81	A6ND01
LCNLLKLCGDHEVMR	MYO15A	3096	Q9UKN7
LHDRKMCVLGLCALI	IPO7	831	O95373
SMIFGVKCKHCRLKC	KSR1	366	Q8IVT5
RHFMLQIALKCADIC	PDE7B	311	Q9NP56
HLCCKKLKILGMPFR	PRAMEF15	181	P0DUQ1
IMCCANATGLHKLKL	JRKL	211	Q9Y4A0
MKLHCCLFTLVASII	MFAP3	1	P55082
KAAKTLCIIMGCFCL	HTR4	256	Q13639
MCVATHQLKRCKIAG	CFHR5	321	Q9BXR6
LLMNALKLCGHKCIP	LYST	2816	Q99698
HCMLAVRKLKKGGRC	EML5	1031	Q05BV3
CFRKVCKIHRMLPAG	DHX37	456	Q8IY37
KRLVLHMKNGAGCPC	SFRP5	241	Q5T4F7
LKHCKRHTGIKDFMC	PRDM15	1156	P57071
MRLCCLGLCKPKIVH	FASTKD2	41	Q9NYY8
KILCKGLPHCMVIVR	FBXL12	301	Q9NXK8
GHLLLSCSMDCKIKL	CDC40	301	O60508
HLCCKKLKILGMPFR	PRAMEF25	181	A6NGN4
CMHILVKCAQRFCKR	SLC36A2	101	Q495M3
HLCCKKLKILGMPFR	PRAMEF27	181	A3QJZ7
LCHFCIDMLNAKLAV	NAPA	211	P54920
KVRHGALTCLCVAMK	CDC42BPA	1321	Q5VT25
KSKNQLEFCCHMLRG	CLOCK	186	O15516
LSYDLHCCGAKRIMK	CIDEC	171	Q96AQ7
HLCCKKLKILGMPFR	PRAMEF4	181	O60810
DLLHLCCKKLKILGM	PRAMEF6	176	Q5VXH4
CVDSLLKMCGNVKHL	RNF213	1156	Q63HN8
AITFKRQFMCKLCHR	ZBTB21	1036	Q9ULJ3
DLCERHGEKLKMFCK	TRIM68	96	Q6AZZ1
CDKAFPMLCSLALHK	RREB1	321	Q92766
HLCCKKLKILGMPFR	PRAMEF9	181	P0DUQ2
LERRHKCSICGKMFK	ZNF574	491	Q6ZN55
DLLHLCCKKLKILGM	PRAMEF5	176	Q5TYX0
ICMKCGLAFIRKAHL	ZNF585B	411	Q52M93
QHLFDLNCKICIGRM	PHF3	1111	Q92576
HLCCKKLKILGMPFR	PRAMEF11	181	O60813
GCKHRCPKLAMARHV	TRAF4	256	Q9BUZ4
VMDNRLHKCLLCGAL	VCPIP1	461	Q96JH7
ECKECGKAFRLHMQL	ZNF780A	586	O75290
ICMKCGLAFIQKAHL	ZNF585A	411	Q6P3V2
FGCGNSIHIKCMKIL	ZSWIM2	166	Q8NEG5
LRASLEMKCKCHGVS	WNT11	201	O96014
KSFCMLLHLCQHKRI	ZNF493	61	Q6ZR52
CFIVVLGGLLKMCLK	SLC9C2	36	Q5TAH2
CMICGKAFRLHSHLI	ZNF461	471	Q8TAF7