Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunction[heparan sulfate]-glucosamine N-sulfotransferase activity

NDST4 NDST3 NDST1

2.75e-084393GO:0015016
GeneOntologyMolecularFunctionN-acetylglucosamine deacetylase activity

NDST4 NDST3 NDST1

2.75e-084393GO:0050119
GeneOntologyMolecularFunctionheparan sulfate sulfotransferase activity

NDST4 NDST3 NDST1

3.08e-0615393GO:0034483
GeneOntologyMolecularFunctionheparan sulfate N-deacetylase activity

NDST3 NDST1

1.11e-053392GO:0102140
GeneOntologyMolecularFunctiondeacetylase activity

NDST4 NDST3 NDST1

6.47e-0540393GO:0019213
GeneOntologyMolecularFunctionsulfotransferase activity

NDST4 NDST3 NDST1

1.68e-0455393GO:0008146
GeneOntologyMolecularFunctioncarboxylic ester hydrolase activity

NDST3 LGALS13 NDST1 ABHD2

2.44e-04157394GO:0052689
GeneOntologyMolecularFunctiontransferase activity, transferring sulphur-containing groups

NDST4 NDST3 NDST1

4.06e-0474393GO:0016782
GeneOntologyMolecularFunctionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

NDST4 NDST3 NDST1

5.29e-0481393GO:0016811
GeneOntologyMolecularFunctiondipeptidase activity

FOLH1B ACE

5.58e-0418392GO:0016805
GeneOntologyMolecularFunctionacid-amino acid ligase activity

TTLL8 TTLL13

9.16e-0423392GO:0016881
GeneOntologyMolecularFunctionnuclear steroid receptor activity

PAQR8 ABHD2

1.08e-0325392GO:0003707
GeneOntologyMolecularFunctionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

NDST4 NDST3 NDST1

2.89e-03146393GO:0016810
GeneOntologyMolecularFunctioncarboxypeptidase activity

FOLH1B ACE

4.13e-0349392GO:0004180
GeneOntologyMolecularFunctionligase activity, forming carbon-nitrogen bonds

TTLL8 TTLL13

4.81e-0353392GO:0016879
GeneOntologyMolecularFunctionnuclear receptor activity

PAQR8 ABHD2

6.13e-0360392GO:0004879
GeneOntologyMolecularFunctionligand-activated transcription factor activity

PAQR8 ABHD2

6.33e-0361392GO:0098531
GeneOntologyMolecularFunctionmetallopeptidase activity

FOLH1B ACE ADAM18

6.94e-03200393GO:0008237
GeneOntologyBiologicalProcessheparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process

NDST4 NDST3 NDST1

3.76e-078403GO:0015014
GeneOntologyBiologicalProcessheparin biosynthetic process

NDST4 NDST3 NDST1

1.10e-0611403GO:0030210
GeneOntologyBiologicalProcessheparin metabolic process

NDST4 NDST3 NDST1

4.51e-0617403GO:0030202
GeneOntologyBiologicalProcesspeptidyl-glutamic acid modification

FOLH1B TTLL8 TTLL13

2.38e-0529403GO:0018200
GeneOntologyBiologicalProcessheparan sulfate proteoglycan biosynthetic process

NDST4 NDST3 NDST1

4.24e-0535403GO:0015012
GeneOntologyBiologicalProcessproteoglycan biosynthetic process

NDST4 NDST3 NDST1

3.38e-0470403GO:0030166
GeneOntologyBiologicalProcesspolysaccharide biosynthetic process

NDST4 NDST3 NDST1

4.31e-0476403GO:0000271
GeneOntologyBiologicalProcessglycosaminoglycan biosynthetic process

NDST4 NDST3 NDST1

4.31e-0476403GO:0006024
GeneOntologyBiologicalProcessaminoglycan biosynthetic process

NDST4 NDST3 NDST1

5.01e-0480403GO:0006023
DomainHSNSD

NDST4 NDST3 NDST1

3.10e-084383PF12062
DomainHeparan_SO4_deacetylase

NDST4 NDST3 NDST1

3.10e-084383IPR021930
DomainSulfotransferase_dom

NDST4 NDST3 NDST1

5.30e-0536383IPR000863
DomainSulfotransfer_1

NDST4 NDST3 NDST1

5.30e-0536383PF00685
Domain-

LGALS13 COL12A1 LMAN1

9.45e-04953832.60.120.200
DomainBTB_2

KCNA7 KCTD5

5.20e-0353382PF02214
DomainT1-type_BTB

KCNA7 KCTD5

5.20e-0353382IPR003131
PathwayKEGG_MEDICUS_REFERENCE_HEPARAN_SULFATE_BIOSYNTHESIS

NDST4 NDST3 NDST1

1.15e-0611283M47921
PathwayKEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE

NDST4 NDST3 NDST1

1.77e-0526283M7330
PathwayREACTOME_HS_GAG_BIOSYNTHESIS

NDST4 NDST3 NDST1

2.48e-0529283MM14802
PathwayREACTOME_HS_GAG_BIOSYNTHESIS

NDST4 NDST3 NDST1

3.04e-0531283M685
PathwayWP_GLYCOSAMINOGLYCAN_SYNTHESIS_IN_FIBROBLASTS

NDST4 NDST3 NDST1

7.11e-0541283M48095
PathwayREACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM

NDST4 NDST3 NDST1

1.63e-0454283MM14633
PathwayREACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM

NDST4 NDST3 NDST1

1.91e-0457283M692
PathwayREACTOME_CARBOXYTERMINAL_POST_TRANSLATIONAL_MODIFICATIONS_OF_TUBULIN

TTLL8 TTLL13

1.29e-0327282MM15549
Pubmed

Lowered expression of heparan sulfate/heparin biosynthesis enzyme N-deacetylase/n-sulfotransferase 1 results in increased sulfation of mast cell heparin.

NDST4 NDST3 NDST1

5.63e-09440322049073
Pubmed

Regulated translation of heparan sulfate N-acetylglucosamine N-deacetylase/n-sulfotransferase isozymes by structured 5'-untranslated regions and internal ribosome entry sites.

NDST4 NDST3 NDST1

5.63e-09440312070138
Pubmed

Multiple isozymes of heparan sulfate/heparin GlcNAc N-deacetylase/GlcN N-sulfotransferase. Structure and activity of the fourth member, NDST4.

NDST4 NDST3 NDST1

1.41e-08540311087757
Pubmed

FGF signaling sustains the odontogenic fate of dental mesenchyme by suppressing β-catenin signaling.

NDST4 NDST3 NDST1

7.86e-08840324067353
Pubmed

Developmental and regional expression of heparan sulfate sulfotransferase genes in the mouse brain.

NDST4 NDST3 NDST1

2.31e-071140315944372
Pubmed

Variant heparan sulfates synthesized in developing mouse brain differentially regulate FGF signaling.

NDST4 NDST3 NDST1

3.08e-071240312460940
Pubmed

Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development.

NDST4 NDST3 NDST1

1.58e-062040317107998
Pubmed

NDST1-dependent heparan sulfate regulates BMP signaling and internalization in lung development.

NDST4 NDST3 NDST1

2.14e-062240319299468
Pubmed

Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family.

NDST3 NDST1

3.87e-0634029915799
Pubmed

Endothelial heparan sulfate deficiency impairs L-selectin- and chemokine-mediated neutrophil trafficking during inflammatory responses.

NDST3 NDST1

7.73e-06440216056228
Pubmed

Heparan Sulfate Proteoglycan Sulfation Regulates Uterine Differentiation and Signaling During Embryo Implantation.

NDST3 NDST1

7.73e-06440229688404
Pubmed

Pentameric assembly of potassium channel tetramerization domain-containing protein 5.

GORASP2 KCTD5

7.73e-06440219361449
Pubmed

Altered heparan sulfate structure in mice with deleted NDST3 gene function.

NDST3 NDST1

2.70e-05740218385133
Pubmed

Analysis of the human protein interactome and comparison with yeast, worm and fly interaction datasets.

GORASP2 KCTD5

8.45e-051240216501559
Pubmed

A targeted multienzyme mechanism for selective microtubule polyglutamylation.

TTLL8 TTLL13

9.98e-051340217499049
Pubmed

Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation.

NDST4 NDST3 NDST1

1.13e-048140339217171
Pubmed

Tubulin polyglutamylase enzymes are members of the TTL domain protein family.

TTLL8 TTLL13

1.16e-041440215890843
Pubmed

LZTR1 is a regulator of RAS ubiquitination and signaling.

GORASP2 ADD3 MINK1

4.26e-0412740330442766
Pubmed

Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.

PELP1 KAT8

5.87e-043140215960975
Pubmed

Choroid plexuses carry nodal-like cilia that undergo axoneme regression from early adult stage.

TTLL8 TTLL13

7.49e-043540237890489
Pubmed

A novel lncRNA MDHDH suppresses glioblastoma multiforme by acting as a scaffold for MDH2 and PSMA1 to regulate NAD+ metabolism and autophagy.

LMAN1 ACO2

9.79e-044040236527092
InteractionNDST4 interactions

NDST4 NDST3 NDST1

3.17e-078373int:NDST4
Cytoband4q26

NDST4 NDST3

6.84e-04444024q26
Cytoband15q26.1

ABHD2 TTLL13

1.03e-035440215q26.1
CytobandEnsembl 112 genes in cytogenetic band chr4q26

NDST4 NDST3

1.07e-0355402chr4q26
Cytoband17p13.2

PELP1 MINK1

1.07e-035540217p13.2
GeneFamilySulfotransferases, membrane bound

NDST4 NDST3 NDST1

3.76e-0537323763
GeneFamilyTubulin tyrosine ligase family

TTLL8 TTLL13

2.73e-0414322779
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCED1B DNAJC5G NDST3 FOLH1B

1.65e-051714046a489a75eeab2a2d48d604682e93599c20a945fe
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCED1B DNAJC5G FOLH1B COL12A1

1.73e-05173404ee972d9cc68755926512fd3bbe1267098c67cd94
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

COL12A1 ACE PLEKHG5 ADD3

3.05e-05200404dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

COL12A1 ACE PLEKHG5 ADD3

3.05e-05200404b2d4e6f3e8e4da62e6b02758ab2ed8f505269f9a
ToppCellParenchymal-10x3prime_v2-Stromal-Peri/Epineurial_-NAF_epineurial|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

COL12A1 PELP1 USP28 MINK1

3.05e-05200404be46efc899d06c55ee297bee3126f69bcdb2048b
Diseaseazoospermia (implicated_via_orthology)

NDST4 NDST3 NDST1

5.64e-0627383DOID:14227 (implicated_via_orthology)
Disease1-linoleoyl-2-arachidonoyl-GPC (18:2/20:4n6) measurement

HAPLN4 ABHD2

4.50e-058382EFO_0800450
Diseaseintellectual disability (implicated_via_orthology)

NDST4 NDST3 NDST1

1.25e-0475383DOID:1059 (implicated_via_orthology)
Diseaselifestyle measurement, depressive symptom measurement

NDST3 COL12A1 CR2

3.37e-04105383EFO_0007006, EFO_0010724
Diseaseproteinuria (implicated_via_orthology)

ACE ADD3

6.87e-0430382DOID:576 (implicated_via_orthology)
Diseaseautism spectrum disorder (implicated_via_orthology)

NDST4 NDST3 NDST1

9.91e-04152383DOID:0060041 (implicated_via_orthology)
DiseaseBrain Ischemia

ACE ADD3

2.73e-0360382C0007786
DiseaseCerebral Ischemia

ACE ADD3

2.73e-0360382C0917798
Diseasecutaneous melanoma, hair color

LRRN2 ADD3

2.91e-0362382EFO_0000389, EFO_0003924

Protein segments in the cluster

PeptideGeneStartEntry
GPVPDTARYYKKHGI

ACO2

641

Q99798
GAKFHVPNVTPYIRY

ACE

516

P12821
GYAYRHPLIREKPRH

ADD3

386

Q9UEY8
ALYGKMGRVRSPHPY

ABHD2

81

P08910
VYRKHPKYVGATFPG

ADAM18

276

Q9Y3Q7
YVPRIAFYAGLRRPH

C1QL4

106

Q86Z23
KGRFVGRPGSYVYVF

ANO2

646

Q9NQ90
EYPHLKPARYRRGFI

NDST3

451

O95803
AKDLGPYVLHGRPYR

FOXH1

141

O75593
YGYLHRIPTRPFEEG

GORASP2

196

Q9H8Y8
PPYQRRGYGKFLIAF

KAT8

321

Q9H7Z6
TPAHAGRRYRVYPEG

LRRN2

466

O75325
RFRLGGVKFPPDIYY

MFI

71

Q8NCR3
VHRGFGRYRPRGPYT

PCED1B

396

Q96HM7
LGLPDRPFYRHVIYA

FOLH1B

371

Q9HBA9
EKFGKGGTYPRRYHV

MAP3K2

256

Q9Y2U5
YPHLKPARYRRGFIH

NDST1

461

P52848
LPHRRFEYKYSFKGP

LMAN1

41

P49257
YPHLKPARYRKGFIH

NDST4

451

Q9H3R1
FGGRVPRPAFVHYDK

PELP1

756

Q8IZL8
GIRIYGFVHRIPPSF

LGALS13

106

Q9UHV8
FREPYIRTGYRPTGH

PAQR8

46

Q8TEZ7
PPFEYHLGRKLALRY

DNAJC5G

46

Q8N7S2
YYQSGGRLRRPAHVP

KCNA7

71

Q96RP8
VPGGYKIRGSTPYRH

CR2

96

P20023
GKVVNYRVVYRPHGR

COL12A1

1021

Q99715
YPGVKRIRGAFHVYP

CFAP70

351

Q5T0N1
KRHLEPLPAGYFYNG

DNAAF9

1111

Q5TEA3
PTYFGPVLNYLRHGK

KCTD5

96

Q9NXV2
EGVVFPYHPRGGRYK

HAPLN4

161

Q86UW8
PYHPRGGRYKLTFAE

HAPLN4

166

Q86UW8
YRDPYHGRPLTKGEL

COLGALT1

396

Q8NBJ5
LLPGDRKPLYHYGRG

MINK1

496

Q8N4C8
YKEQGYHRLPPGALA

RIN1

676

Q13671
QARGTYPRPYHGFIA

SLC25A34

41

Q6PIV7
YPRPYHGFIASVAAV

SLC25A34

46

Q6PIV7
KYGRVGDVYIPREPH

SRSF8

36

Q9BRL6
YRFGGHYLRVKAPAK

PLEKHG5

136

O94827
YGHYPVVRAALRRKG

TTLL8

61

A6PVC2
LERYVKYGSGPARFP

USP28

426

Q96RU2
PPGSVHYKKLYVSRG

VGLL1

206

Q99990
PGKSRIPGRDHRRYY

ZFTA

91

C9JLR9
SHLGKYRRIYPGPDT

TTLL13

471

A6NNM8