Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	coumarin 7-hydroxylase activity	CYP2A6 CYP2A7 CYP2A13	1.29e-07	3	102	3	GO:0008389
GeneOntologyMolecularFunction	arachidonate monooxygenase activity	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	2.33e-07	27	102	5	GO:0008391
GeneOntologyMolecularFunction	steroid hydroxylase activity	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	7.79e-07	34	102	5	GO:0008395
GeneOntologyMolecularFunction	aromatase activity	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	9.06e-07	35	102	5	GO:0070330
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	5.03e-06	49	102	5	GO:0016712
GeneOntologyMolecularFunction	anandamide 8,9 epoxidase activity	CYP2D7 CYP2D6	1.54e-04	4	102	2	GO:0062187
GeneOntologyMolecularFunction	anandamide 11,12 epoxidase activity	CYP2D7 CYP2D6	1.54e-04	4	102	2	GO:0062188
GeneOntologyMolecularFunction	steroid 21-monooxygenase activity	CYP2D7 CYP2D6	1.54e-04	4	102	2	GO:0004509
GeneOntologyMolecularFunction	progesterone 21-hydroxylase activity	CYP2D7 CYP2D6	1.54e-04	4	102	2	GO:0106309
GeneOntologyMolecularFunction	arachidonate epoxygenase activity	CYP2A6 CYP2A7 CYP2A13	2.42e-04	24	102	3	GO:0008392
GeneOntologyMolecularFunction	neuropilin binding	TAOK2 PXN	2.56e-04	5	102	2	GO:0038191
GeneOntologyMolecularFunction	monooxygenase activity	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	3.10e-04	115	102	5	GO:0004497
GeneOntologyMolecularFunction	fatty acyl-CoA hydrolase activity	ACOT1 ACOT4 ACOT2	3.46e-04	27	102	3	GO:0047617
GeneOntologyMolecularFunction	anandamide 14,15 epoxidase activity	CYP2D7 CYP2D6	3.82e-04	6	102	2	GO:0062189
GeneOntologyMolecularFunction	anandamide epoxidase activity	CYP2D7 CYP2D6	3.82e-04	6	102	2	GO:0062186
GeneOntologyMolecularFunction	acyl-CoA hydrolase activity	ACOT1 ACOT4 ACOT2	3.86e-04	28	102	3	GO:0016289
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	HIC1 RARB ETV2 SOX18 TEAD1 SOX8 HMX1 EOMES BCL11B ZFHX4 ZNF398 TPRX1 IRX2 GLIS1 FOXD4 ZNF513 NPAS1	7.71e-04	1412	102	17	GO:0000981
GeneOntologyMolecularFunction	heme binding	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	1.17e-03	154	102	5	GO:0020037
GeneOntologyMolecularFunction	tetrapyrrole binding	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	1.54e-03	164	102	5	GO:0046906
GeneOntologyMolecularFunction	iron ion binding	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	1.63e-03	166	102	5	GO:0005506
GeneOntologyMolecularFunction	thiolester hydrolase activity	ACOT1 ACOT4 ACOT2	1.78e-03	47	102	3	GO:0016790
GeneOntologyBiologicalProcess	phenylpropanoid metabolic process	CYP2A6 CYP2A7 CYP2A13 CYP2D6	1.11e-07	10	101	4	GO:0009698
GeneOntologyBiologicalProcess	coumarin metabolic process	CYP2A6 CYP2A7 CYP2A13 CYP2D6	1.11e-07	10	101	4	GO:0009804
GeneOntologyBiologicalProcess	long-chain fatty acid metabolic process	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6 ACOT1 ACOT4 ACOT2	1.72e-07	124	101	8	GO:0001676
GeneOntologyBiologicalProcess	regulation of sensory perception of pain	SMR3A GRIN2D GRM1 SMR3B	4.46e-06	23	101	4	GO:0051930
GeneOntologyBiologicalProcess	regulation of sensory perception	SMR3A GRIN2D GRM1 SMR3B	5.34e-06	24	101	4	GO:0051931
GeneOntologyBiologicalProcess	arachidonate metabolic process	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	2.08e-05	68	101	5	GO:0019369
GeneOntologyBiologicalProcess	saturated monocarboxylic acid metabolic process	ACOT1 ACOT4	2.37e-05	2	101	2	GO:0032788
GeneOntologyBiologicalProcess	unsaturated monocarboxylic acid metabolic process	ACOT1 ACOT4	2.37e-05	2	101	2	GO:0032789
GeneOntologyBiologicalProcess	long-chain fatty-acyl-CoA catabolic process	ACOT1 ACOT2	7.10e-05	3	101	2	GO:0036116
GeneOntologyBiologicalProcess	serotonin biosynthetic process from tryptophan	CYP2D7 CYP2D6	7.10e-05	3	101	2	GO:0006587
GeneOntologyBiologicalProcess	tissue morphogenesis	FIGNL2 ETV2 SOX18 TRIM71 TEAD1 SOX8 EOMES FMN1 ARMC5 PXN AJUBA IRX2 CRB2	7.50e-05	750	101	13	GO:0048729
GeneOntologyBiologicalProcess	positive regulation of protein-containing complex assembly	ABCA1 LGALS3 FMN1 AJUBA EPN1 BAIAP2L2 VCP	1.28e-04	227	101	7	GO:0031334
GeneOntologyBiologicalProcess	epoxygenase P450 pathway	CYP2A6 CYP2A7 CYP2A13	1.64e-04	22	101	3	GO:0019373
GeneOntologyBiologicalProcess	negative regulation of transcription by RNA polymerase II	HIC1 RARB ATN1 TRO SOX18 SOX8 HMX1 EOMES PRDM13 CTBP2 HDAC10 AJUBA IRX2 GLIS1 NPAS1	1.82e-04	1053	101	15	GO:0000122
GeneOntologyBiologicalProcess	secondary metabolic process	CYP2A6 CYP2A7 CYP2A13 CYP2D6	3.28e-04	67	101	4	GO:0019748
MousePheno	decreased intestinal cholesterol absorption	CYP2A6 CYP2A7 CYP2A13 ABCA1	2.85e-06	17	85	4	MP:0002647
MousePheno	abnormal intestinal cholesterol absorption	CYP2A6 CYP2A7 CYP2A13 ABCA1	4.60e-06	19	85	4	MP:0002645
MousePheno	abnormal intestinal lipid absorption	CYP2A6 CYP2A7 CYP2A13 ABCA1	3.53e-05	31	85	4	MP:0005342
Domain	Cyt_P450_E_grp-I_CYP2A-like	CYP2A6 CYP2A7 CYP2A13	5.93e-07	4	100	3	IPR008067
Domain	Bile_Hydr_Trans	ACOT1 ACOT4 ACOT2	5.93e-07	4	100	3	PF04775
Domain	Thio_Ohase/aa_AcTrfase	ACOT1 ACOT4 ACOT2	5.93e-07	4	100	3	IPR006862
Domain	Acyl-CoA_thioEstase_long-chain	ACOT1 ACOT4 ACOT2	5.93e-07	4	100	3	IPR016662
Domain	BAAT_C	ACOT1 ACOT4 ACOT2	1.48e-06	5	100	3	IPR014940
Domain	BAAT_C	ACOT1 ACOT4 ACOT2	1.48e-06	5	100	3	PF08840
Domain	Atrophin-like	ATN1 RERE	2.84e-05	2	100	2	IPR002951
Domain	Atrophin-1	ATN1 RERE	2.84e-05	2	100	2	PF03154
Domain	SMR-like	SMR3A SMR3B	8.48e-05	3	100	2	IPR026288
Domain	PROL5-SMR	SMR3A SMR3B	8.48e-05	3	100	2	PF15621
Domain	Cyt_P450_E_grp-I	CYP2A6 CYP2A7 CYP2A13 CYP2D6	9.74e-05	45	100	4	IPR002401
Domain	Cyt_P450_CS	CYP2A6 CYP2A7 CYP2A13 CYP2D6	1.85e-04	53	100	4	IPR017972
Domain	CYTOCHROME_P450	CYP2A6 CYP2A7 CYP2A13 CYP2D6	2.46e-04	57	100	4	PS00086
Domain	-	CYP2A6 CYP2A7 CYP2A13 CYP2D6	2.63e-04	58	100	4	1.10.630.10
Domain	p450	CYP2A6 CYP2A7 CYP2A13 CYP2D6	2.63e-04	58	100	4	PF00067
Domain	Cyt_P450	CYP2A6 CYP2A7 CYP2A13 CYP2D6	3.00e-04	60	100	4	IPR001128
Domain	Pectin_lyase_fold/virulence	CEMIP2 FBXO10	7.78e-04	8	100	2	IPR011050
Domain	FH2	FMN1 DIAPH2	2.85e-03	15	100	2	PS51444
Domain	FH2_Formin	FMN1 DIAPH2	2.85e-03	15	100	2	IPR015425
Domain	FH2	FMN1 DIAPH2	2.85e-03	15	100	2	PF02181
Domain	FH2	FMN1 DIAPH2	2.85e-03	15	100	2	SM00498
Domain	HMG_box	HMGXB4 SOX18 SOX8	2.87e-03	53	100	3	PF00505
Domain	HMG_BOX_2	HMGXB4 SOX18 SOX8	3.03e-03	54	100	3	PS50118
Domain	HMG	HMGXB4 SOX18 SOX8	3.03e-03	54	100	3	SM00398
Domain	-	HMGXB4 SOX18 SOX8	3.19e-03	55	100	3	1.10.30.10
Domain	HMG_box_dom	HMGXB4 SOX18 SOX8	5.12e-03	65	100	3	IPR009071
Domain	Znf_C2H2_jaz	ZNF385A GPATCH8	6.11e-03	22	100	2	IPR022755
Domain	zf-C2H2_jaz	ZNF385A GPATCH8	6.11e-03	22	100	2	PF12171
Domain	G_patch	GPATCH8 GPANK1	6.67e-03	23	100	2	SM00443
Domain	G_patch_dom	GPATCH8 GPANK1	6.67e-03	23	100	2	IPR000467
Domain	ZnF_RBZ	DZANK1 SHARPIN	6.67e-03	23	100	2	SM00547
Domain	G_PATCH	GPATCH8 GPANK1	6.67e-03	23	100	2	PS50174
Domain	G-patch	GPATCH8 GPANK1	6.67e-03	23	100	2	PF01585
Pathway	REACTOME_CYP2E1_REACTIONS	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	2.01e-09	12	70	5	MM14847
Pathway	REACTOME_FATTY_ACIDS	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	2.13e-08	18	70	5	MM14841
Pathway	REACTOME_XENOBIOTICS	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	1.28e-07	25	70	5	MM14846
Pathway	REACTOME_CYP2E1_REACTIONS	CYP2A6 CYP2A7 CYP2A13 CYP2D6	1.79e-07	11	70	4	M27130
Pathway	REACTOME_XENOBIOTICS	CYP2A6 CYP2A7 CYP2A13 CYP2D6	4.60e-06	23	70	4	M5372
Pathway	REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	1.85e-05	66	70	5	MM14839
Pathway	REACTOME_FATTY_ACIDS	CYP2A7 CYP2A13 CYP2D6	5.11e-05	15	70	3	M27126
Pathway	WP_MESODERMAL_COMMITMENT_PATHWAY	RARB TRIM71 TEAD1 EOMES ZFHX4 CTBP2	1.10e-04	153	70	6	M39546
Pathway	KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS	ACOT1 ACOT4 ACOT2	1.69e-04	22	70	3	M11673
Pathway	REACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	1.72e-04	105	70	5	MM14842
Pathway	KEGG_MEDICUS_ENV_FACTOR_NNK_TO_DNA_ADDUCTS	CYP2A6 CYP2A13	2.41e-04	5	70	2	M47808
Pathway	WP_OXIDATION_BY_CYTOCHROME_P450	CYP2A6 CYP2A7 CYP2A13 CYP2D6	2.50e-04	62	70	4	M39653
Pathway	REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE	CYP2A6 CYP2A7 CYP2A13 CYP2D6	2.83e-04	64	70	4	M5650
Pathway	WP_7OXOC_AND_7BETAHC_PATHWAYS	ACOT1 ACOT4 ACOT2	3.15e-04	27	70	3	M40054
Pathway	KEGG_DRUG_METABOLISM_CYTOCHROME_P450	CYP2A6 CYP2A7 CYP2A13 CYP2D6	4.45e-04	72	70	4	M9257
Pubmed	A DNA methylation site in the male-specific P450 (Cyp 2d-9) promoter and binding of the heteromeric transcription factor GABP.	CYP2A6 CYP2A7 CYP2A13 CYP2D6	7.84e-11	4	105	4	7565685
Pubmed	A census of human transcription factors: function, expression and evolution.	HIC1 RARB ETV2 SOX18 ZNF385A TEAD1 SOX8 HMX1 EOMES BCL11B ZFHX4 ZNF398 TPRX1 RERE IRX2 GLIS1 FOXD4 NPAS1	2.56e-10	908	105	18	19274049
Pubmed	Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses.	CYP2A6 CYP2A7 CYP2A13 CYP2D6	2.73e-09	7	105	4	9630227
Pubmed	Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition.	CYP2A6 CYP2A7 CYP2A13	2.67e-08	3	105	3	31645370
Pubmed	A trans-acting locus regulates transcriptional repression of the female-specific steroid 15 alpha-hydroxylase gene in male mice.	CYP2A6 CYP2A7 CYP2A13	2.67e-08	3	105	3	8297477
Pubmed	Lack of the steroid 15 alpha-hydroxylase gene (Cyp2a-4) in wild mouse strain Mus spretus: rapid evolution of the P450 gene superfamily.	CYP2A6 CYP2A7 CYP2A13	2.67e-08	3	105	3	8188299
Pubmed	Comparison of hamster and mouse reveals interspecies differences in the regulation of hepatic CYP2A isozymes.	CYP2A6 CYP2A7 CYP2A13	2.67e-08	3	105	3	8250953
Pubmed	The structure and characterization of type I P-450(15) alpha gene as major steroid 15 alpha-hydroxylase and its comparison with type II P-450(15) alpha gene.	CYP2A6 CYP2A7 CYP2A13	2.67e-08	3	105	3	2703500
Pubmed	Alteration of the substrate specificity of mouse 2A P450s by the identity of residue-209: steroid-binding site and orientation.	CYP2A6 CYP2A7 CYP2A13	2.67e-08	3	105	3	22217847
Pubmed	Differential distribution of CYP2A6 and CYP2A13 in the human respiratory tract.	CYP2A6 CYP2A7 CYP2A13	2.67e-08	3	105	3	22890016
Pubmed	Reciprocal regulation of sex-dependent expression of testosterone 15 alpha-hydroxylase (P-450(15 alpha)) in liver and kidney of male mice by androgen. Evidence for a single gene.	CYP2A6 CYP2A7 CYP2A13	2.67e-08	3	105	3	3346244
Pubmed	Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue.	CYP2A6 CYP2A7 CYP2A13	2.67e-08	3	105	3	2733794
Pubmed	Peroxisome proliferator-induced long chain acyl-CoA thioesterases comprise a highly conserved novel multi-gene family involved in lipid metabolism.	ACOT1 ACOT4 ACOT2	2.67e-08	3	105	3	10567408
Pubmed	Site-directed mutagenesis of mouse steroid 7 alpha-hydroxylase (cytochrome P-450(7) alpha): role of residue-209 in determining steroid-cytochrome P-450 interaction.	CYP2A6 CYP2A7 CYP2A13	2.67e-08	3	105	3	8484736
Pubmed	Cerium-induced strain-dependent increase in Cyp2a-4/5 (cytochrome P4502a-4/5) expression in the liver and kidneys of inbred mice.	CYP2A6 CYP2A7 CYP2A13	2.67e-08	3	105	3	1417950
Pubmed	Impact of nicotine metabolism on nicotine's pharmacological effects and behavioral responses: insights from a Cyp2a(4/5)bgs-null mouse.	CYP2A6 CYP2A7 CYP2A13	2.67e-08	3	105	3	24045421
Pubmed	Highly homologous mouse Cyp2a4 and Cyp2a5 genes are differentially expressed in the liver and both express long non-coding antisense RNAs.	CYP2A6 CYP2A7 CYP2A13	2.67e-08	3	105	3	32987105
Pubmed	Mouse steroid 15 alpha-hydroxylase gene family: identification of type II P-450(15)alpha as coumarin 7-hydroxylase.	CYP2A6 CYP2A7 CYP2A13	2.67e-08	3	105	3	2765478
Pubmed	Sexual dimorphism of testosterone 15 alpha-hydroxylase mRNA levels in mouse liver. cDNA cloning and regulation.	CYP2A6 CYP2A7 CYP2A13	2.67e-08	3	105	3	2415518
Pubmed	Establishment and analysis of a mouse model that regulates sex-related differences in liver drug metabolism.	CYP2A6 CYP2A7 CYP2A13 CYP2D6	1.04e-07	15	105	4	29968852
Pubmed	Circadian expression of the steroid 15 alpha-hydroxylase (Cyp2a4) and coumarin 7-hydroxylase (Cyp2a5) genes in mouse liver is regulated by the PAR leucine zipper transcription factor DBP.	CYP2A6 CYP2A7 CYP2A13	1.07e-07	4	105	3	10490589
Pubmed	Two steroid 15 alpha-hydroxylase genes and a homologous gene family in mice.	CYP2A6 CYP2A7 CYP2A13	1.07e-07	4	105	3	1970547
Pubmed	Molecular cloning and characterization of two mouse peroxisome proliferator-activated receptor alpha (PPARalpha)-regulated peroxisomal acyl-CoA thioesterases.	ACOT1 ACOT4 ACOT2	1.07e-07	4	105	3	15007068
Pubmed	Transcriptional regulation by HNF-4 of the steroid 15alpha-hydroxylase P450 (Cyp2a-4) gene in mouse liver.	CYP2A6 CYP2A7 CYP2A13	1.07e-07	4	105	3	9408084
Pubmed	Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.	RARB HMGXB4 ETV2 SOX18 HMX1 ZFHX4 AJUBA IRX2 FOXD4	1.13e-07	263	105	9	20932939
Pubmed	Interaction network of human early embryonic transcription factors.	BCL9L ATN1 TEAD1 PRR12 BCL11B ZFHX4 TPRX1 CTBP2 RERE INO80E	1.19e-07	351	105	10	38297188
Pubmed	Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic Cyp Gene Expression in the Adult Mouse Liver.	CYP2A6 CYP2A7 CYP2A13 CYP2D6	1.81e-07	17	105	4	27197076
Pubmed	Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues.	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	2.25e-07	44	105	5	12745259
Pubmed	Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs.	ACOT1 ACOT4 ACOT2	2.66e-07	5	105	3	16940157
Pubmed	Molecular genetics of the human cytochrome P450 monooxygenase superfamily.	CYP2A6 CYP2A7 CYP2A13 CYP2D6	3.66e-07	20	105	4	9890157
Pubmed	A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles.	CYP2A6 CYP2A7 CYP2A13	5.31e-07	6	105	3	7668294
Pubmed	Organization and evolution of the cytochrome P450 CYP2A-2B-2F subfamily gene cluster on human chromosome 19.	CYP2A6 CYP2A7 CYP2A13	5.31e-07	6	105	3	8587134
Pubmed	Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS.	CYP2A6 CYP2A7 CYP2A13 CYP2D6 ACOT1	8.42e-07	57	105	5	17208939
Pubmed	Organization and evolution of the Cyp2 gene cluster on mouse chromosome 7, and comparison with the syntenic human cluster.	CYP2A6 CYP2A7 CYP2A13	9.28e-07	7	105	3	14630516
Pubmed	Maternal DHA intake in mice increased DHA metabolites in the pup brain and ameliorated MeHg-induced behavioral disorder.	CYP2A6 CYP2A7 CYP2A13	2.22e-06	9	105	3	37838304
Pubmed	A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases.	ACOT1 ACOT4 ACOT2	2.22e-06	9	105	3	16103133
Pubmed	Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	2.36e-06	70	105	5	15128046
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	BCL9L CPSF6 HMGXB4 ZNF385A GPATCH8 LGALS3 C6orf132 TAOK2 PRR12 SRRT PXN HELZ CTBP2 UNC93B1 ZNF598 EPN1 INO80E	2.47e-06	1497	105	17	31527615
Pubmed	ZEB1 Represses Neural Differentiation and Cooperates with CTBP2 to Dynamically Regulate Cell Migration during Neocortex Development.	EOMES BCL11B CTBP2	5.77e-06	12	105	3	31116980
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	HIC1 RARB ETV2 SOX18 TEAD1 SOX8 HMX1 EOMES BCL11B GLIS1	6.17e-06	544	105	10	28473536
Pubmed	Characterization of a novel CYP2A7/CYP2A6 hybrid allele (CYP2A6*12) that causes reduced CYP2A6 activity.	CYP2A6 CYP2A7	9.03e-06	2	105	2	12325023
Pubmed	Suppressed hepatocyte proliferation via a ROS-HNE-P21 pathway is associated with nicotine- and cotinine-enhanced alcoholic fatty liver in mice.	CYP2A6 CYP2A13	9.03e-06	2	105	2	30876690
Pubmed	CYP2A5 induction and hepatocellular stress: an adaptive response to perturbations of heme homeostasis.	CYP2A6 CYP2A13	9.03e-06	2	105	2	21395539
Pubmed	Species differences in coumarin metabolism: a molecular modelling evaluation of CYP2A interactions.	CYP2A6 CYP2A13	9.03e-06	2	105	2	12162851
Pubmed	Molecular characterization of the murine Coh locus: an amino acid difference at position 117 confers high and low coumarin 7-hydroxylase activity in P450coh.	CYP2A6 CYP2A13	9.03e-06	2	105	2	1302041
Pubmed	Structural alteration of mouse P450coh by mutation of glycine-207 to proline: spin equilibrium, enzyme kinetics, and heat sensitivity.	CYP2A6 CYP2A13	9.03e-06	2	105	2	8395817
Pubmed	Protein binding of a DRPLA family through arginine-glutamic acid dipeptide repeats is enhanced by extended polyglutamine.	ATN1 RERE	9.03e-06	2	105	2	10814707
Pubmed	Absence of cytochrome P450 2A5 enhances alcohol-induced liver injury in mice.	CYP2A6 CYP2A13	9.03e-06	2	105	2	25804444
Pubmed	Effect of pyrazole, cobalt and phenobarbital on mouse liver cytochrome P-450 2a-4/5 (Cyp2a-4/5) expression.	CYP2A6 CYP2A13	9.03e-06	2	105	2	1520280
Pubmed	Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: in vivo studies using a CYP2A13-humanized mouse model.	CYP2A6 CYP2A13	9.03e-06	2	105	2	23917075
Pubmed	Molecular evolution of the CYP2D subfamily in primates: purifying selection on substrate recognition sites without the frequent or long-tract gene conversion.	CYP2D7 CYP2D6	9.03e-06	2	105	2	25808902
Pubmed	CYP2A7 polymorphic alleles confound the genotyping of CYP2A6*4A allele.	CYP2A6 CYP2A7	9.03e-06	2	105	2	16636685
Pubmed	Genomic Landscape of Experimental Bladder Cancer in Rodents and Its Application to Human Bladder Cancer: Gene Amplification and Potential Overexpression of Cyp2a5/CYP2A6 Are Associated with the Invasive Phenotype.	CYP2A6 CYP2A13	9.03e-06	2	105	2	27902773
Pubmed	Polymorphisms in CYP2D6 duplication-negative individuals with the ultrarapid metabolizer phenotype: a role for the CYP2D6*35 allele in ultrarapid metabolism?	CYP2D7 CYP2D6	9.03e-06	2	105	2	11207030
Pubmed	Circadian Regulation of Hepatic Cytochrome P450 2a5 by Peroxisome Proliferator-Activated Receptor γ.	CYP2A6 CYP2A13	9.03e-06	2	105	2	30154104
Pubmed	Expression of CYP2A genes in human liver and extrahepatic tissues.	CYP2A7 CYP2A13	9.03e-06	2	105	2	10353262
Pubmed	Acyl-CoA thioesterases belong to a novel gene family of peroxisome proliferator-regulated enzymes involved in lipid metabolism.	ACOT1 ACOT2	9.03e-06	2	105	2	11330065
Pubmed	Mechanism-based inhibition of cytochrome P450 (CYP)2A6 by chalepensin in recombinant systems, in human liver microsomes and in mice in vivo.	CYP2A6 CYP2A13	9.03e-06	2	105	2	21418183
Pubmed	Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone binding and access channel in human cytochrome P450 2A6 and 2A13 enzymes.	CYP2A13 CYP2D6	9.03e-06	2	105	2	22700965
Pubmed	Characterization of the common genetic defect in humans deficient in debrisoquine metabolism.	CYP2D7 CYP2D6	9.03e-06	2	105	2	3123997
Pubmed	Role of CYP2A5 in the clearance of nicotine and cotinine: insights from studies on a Cyp2a5-null mouse model.	CYP2A6 CYP2A13	9.03e-06	2	105	2	19923441
Pubmed	Effects of lipopolysaccharide-stimulated inflammation and pyrazole-mediated hepatocellular injury on mouse hepatic Cyp2a5 expression.	CYP2A6 CYP2A13	9.03e-06	2	105	2	12499123
Pubmed	Function and regulation of the Cyp2a5/CYP2A6 genes in response to toxic insults in the liver.	CYP2A6 CYP2A13	9.03e-06	2	105	2	22497566
Pubmed	The role of CYP2A5 in liver injury and fibrosis: chemical-specific difference.	CYP2A6 CYP2A13	9.03e-06	2	105	2	26363552
Pubmed	Mouse liver P450Coh: genetic regulation of the pyrazole-inducible enzyme and comparison with other P450 isoenzymes.	CYP2A6 CYP2A13	9.03e-06	2	105	2	2712571
Pubmed	Characterization of Cyp2d22, a novel cytochrome P450 expressed in mouse mammary cells.	CYP2D7 CYP2D6	9.03e-06	2	105	2	11032406
Pubmed	Evaluation of inhibition selectivity for human cytochrome P450 2A enzymes.	CYP2A6 CYP2A13	9.03e-06	2	105	2	22696418
Pubmed	Nicotine enhances alcoholic fatty liver in mice: Role of CYP2A5.	CYP2A6 CYP2A13	9.03e-06	2	105	2	30222954
Pubmed	Up-regulation of CYP2A5 expression by porphyrinogenic agents in mouse liver.	CYP2A6 CYP2A13	9.03e-06	2	105	2	7543189
Pubmed	Characterization and regulation of sex-specific mouse steroid hydroxylase genes.	CYP2A6 CYP2A13	9.03e-06	2	105	2	2372744
Pubmed	The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes.	CYP2A6 CYP2A7	9.03e-06	2	105	2	2322567
Pubmed	Acyl-CoA thioesterase-2 facilitates mitochondrial fatty acid oxidation in the liver.	ACOT1 ACOT2	9.03e-06	2	105	2	25114170
Pubmed	Metabolic effects of CYP2A6 and CYP2A13 on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced gene mutation--a mammalian cell-based mutagenesis approach.	CYP2A6 CYP2A13	9.03e-06	2	105	2	21473878
Pubmed	The CYP2A gene subfamily: species differences, regulation, catalytic activities and role in chemical carcinogenesis.	CYP2A6 CYP2A13	9.03e-06	2	105	2	7581481
Pubmed	Expression and alternative splicing of the cytochrome P-450 CYP2A7.	CYP2A6 CYP2A7	9.03e-06	2	105	2	7864805
Pubmed	Interstrain differences in the expression and activity of Cyp2a5 in the mouse liver.	CYP2A6 CYP2A13	9.03e-06	2	105	2	28298240
Pubmed	Genetic polymorphisms for a phenobarbital-inducible cytochrome P-450 map to the Coh locus in mice.	CYP2A6 CYP2A13	9.03e-06	2	105	2	6309775
Pubmed	Role of CYP2A5 in the bioactivation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mice.	CYP2A6 CYP2A13	9.03e-06	2	105	2	22262919
Pubmed	Modulation of cytochrome P450 2A5 activity by lipopolysaccharide: low-dose effects and non-monotonic dose-response relationship.	CYP2A6 CYP2A13	9.03e-06	2	105	2	25635819
Pubmed	The expression of CYP2D22, an ortholog of human CYP2D6, in mouse striatum and its modulation in 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease phenotype and nicotine-mediated neuroprotection.	CYP2D7 CYP2D6	9.03e-06	2	105	2	19594327
Pubmed	Coding-noncoding gene expression in intrahepatic cholangiocarcinoma.	CYP2D7 CYP2D6	9.03e-06	2	105	2	26297049
Pubmed	Genetic variation between mice in their metabolism of coumarin and its derivatives.	CYP2A6 CYP2A13	9.03e-06	2	105	2	566237
Pubmed	Identification and characterization of a 44 kDa protein that binds specifically to the 3'-untranslated region of CYP2a5 mRNA: inducibility, subcellular distribution and possible role in mRNA stabilization.	CYP2A6 CYP2A13	9.03e-06	2	105	2	8611142
Pubmed	A frameshift mutation and alternate splicing in human brain generate a functional form of the pseudogene cytochrome P4502D7 that demethylates codeine to morphine.	CYP2D7 CYP2D6	9.03e-06	2	105	2	15051713
Pubmed	Coumarin toxicity in different strains of mice.	CYP2A6 CYP2A13	9.03e-06	2	105	2	665441
Pubmed	Essential role of the cytochrome P450 enzyme CYP2A5 in olfactory mucosal toxicity of naphthalene.	CYP2A6 CYP2A13	9.03e-06	2	105	2	24104196
Pubmed	Novel DNA sequence variations of cytochrome P450 genes in the Han Chinese population.	CYP2A6 CYP2A13 CYP2D6	9.50e-06	14	105	3	19290787
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	BCL9L ATN1 CPSF6 TEAD1 GPATCH8 PRR12 DAZAP1 ALDH16A1 HELZ	1.06e-05	457	105	9	32344865
Pubmed	Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner.	ACOT1 EOMES BCL11B ACOT2	1.27e-05	47	105	4	31097699
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	ATN1 CPSF6 TRO GPATCH8 DZANK1 CTBP2 RERE AJUBA LTBP4 RAI2	1.61e-05	608	105	10	16713569
Pubmed	ARX regulates cortical intermediate progenitor cell expansion and upper layer neuron formation through repression of Cdkn1c.	RARB EOMES BCL11B	2.50e-05	19	105	3	23968833
Pubmed	Expression of cytochrome P450 2A5 in a glucose-6-phosphate dehydrogenase-deficient mouse model of oxidative stress.	CYP2A6 CYP2A13	2.70e-05	3	105	2	18068688
Pubmed	CYP2A6/2A7 and CYP2E1 expression in human oesophageal mucosa: regional and inter-individual variation in expression and relevance to nitrosamine metabolism.	CYP2A6 CYP2A7	2.70e-05	3	105	2	11960914
Pubmed	Rip locus: regulation of female-specific isozyme (I-P-450(16 alpha) of testosterone 16 alpha-hydroxylase in mouse liver, chromosome localization, and cloning of P-450 cDNA.	CYP2A6 CYP2A13	2.70e-05	3	105	2	3219345
Pubmed	Zfp30, a KRAB domain containing zinc finger protein gene, maps to mouse chromosome 7.	CYP2A6 CYP2A13	2.70e-05	3	105	2	7849402
Pubmed	Mechanisms of olfactory toxicity of the herbicide 2,6-dichlorobenzonitrile: essential roles of CYP2A5 and target-tissue metabolic activation.	CYP2A6 CYP2A13	2.70e-05	3	105	2	20840855
Pubmed	Hypermethylated in cancer 1 (HIC1) suppresses bladder cancer progression by targeting yes-associated protein (YAP) pathway.	HIC1 TEAD1	2.70e-05	3	105	2	30417565
Pubmed	Cutting Edge: Divergent Requirement of T-Box Transcription Factors in Effector and Memory NK Cells.	NDOR1 EOMES	2.70e-05	3	105	2	29440505
Pubmed	Acyl-Coa Thioesterases: A Rheostat That Controls Activated Fatty Acids Modulates Dengue Virus Serotype 2 Replication.	ACOT1 ACOT2	2.70e-05	3	105	2	35215835
Pubmed	Close linkage of the cytochrome P450IIA gene subfamily (Cyp2a) to Cyp2b and Coh on mouse chromosome 7.	CYP2A6 CYP2A13	2.70e-05	3	105	2	1973143
Interaction	CYP2A7 interactions	CYP2A6 CYP2A7 CYP2A13	1.26e-07	3	102	3	int:CYP2A7
Interaction	EGR2 interactions	BCL9L ATN1 SOX8 PRR12 BCL11B ZFHX4 RERE INO80E	2.54e-06	171	102	8	int:EGR2
Interaction	TLE3 interactions	BCL9L ATN1 TEAD1 GPATCH8 PRR12 SRRT BCL11B HELZ CTBP2 RERE VCP	3.22e-06	376	102	11	int:TLE3
Interaction	CYP2A6 interactions	CYP2A6 CYP2A7 TRO	1.03e-05	9	102	3	int:CYP2A6
Interaction	ALG13 interactions	MIA3 ATN1 CPSF6 GPATCH8 PRR12 HELZ RERE	4.05e-05	183	102	7	int:ALG13
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	CYP2A6 CYP2A7 CYP2A13 ETV2 GRIN2D PRR12 ALDH16A1 TPRX1 EPN1 LTBP4 ARHGAP33 NPAS1	1.89e-05	1192	105	12	chr19q13
Cytoband	19q13.33	GRIN2D PRR12 ALDH16A1 TPRX1	1.07e-04	106	105	4	19q13.33
Cytoband	Ensembl 112 genes in cytogenetic band chr22q13	CYP2D7 CYP2D6 HDAC10 BAIAP2L2 SHISA8	9.99e-04	330	105	5	chr22q13
Cytoband	22q13.1	CYP2D6 HMGXB4 BAIAP2L2	1.00e-03	85	105	3	22q13.1
Cytoband	14q24.3	ACOT1 ACOT4 ACOT2	1.30e-03	93	105	3	14q24.3
GeneFamily	Cytochrome P450 family 2	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	3.16e-07	35	75	5	1001
GeneFamily	Acyl-CoA thioesterases	ACOT1 ACOT4 ACOT2	8.06e-06	10	75	3	41
Coexpression	WENG_POR_DOSAGE	CYP2A6 CYP2A7 CYP2A13 ACOT1 ACOT2	1.18e-07	30	104	5	MM1199
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA1 WIPF1 RTN1 CEMIP2 SCNN1A GLIS1	3.72e-06	175	105	6	cf53a15bfb37b6019e7052ffdf594a9ac040900e
ToppCell	facs-Heart\|facs / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIC1 SOX18 ARHGEF25 C1QTNF7 LTBP4 MN1	7.33e-06	197	105	6	6a9571c0a3238b39214afdece93d7541bc8a0a70
ToppCell	LPS_only-Myeloid-Monocytes,_Macrophages-Erythroid\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ATN1 CITED4 ZNF598 MN1 GPANK1	1.97e-05	139	105	5	d96e5c17582f1576fa09d6bad35c418b6248448c
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-lymphocytic-T_lymphocytic-type_I_NK_T_cell\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	TICRR ZNF385A CITED4 CTBP2 MN1	2.50e-05	146	105	5	447c05414eda71681a0c07baba900f88ed6165ed
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l21\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PRPF8 TAOK2 CITED4 BCL11B TTLL4	2.75e-05	149	105	5	65778f19599b4955c0a16f0121237656449431fb
ToppCell	Healthy_donor-B_cell\|World / disease group, cell group and cell class (v2)	PRR22 ARHGEF25 FBXO10 C2CD4D ZNF398	2.84e-05	150	105	5	a2dfed562de7f58f902b547acec5a13853c80c4c
ToppCell	wk_15-18-Mesenchymal-Myofibro_&_SMC-Myofibro_2\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	TEAD1 HMX1 C1QTNF7 RAI2 FOXD4	3.54e-05	157	105	5	b9d04ee417c0d8ea0801d10f1c54e138587009fd
ToppCell	facs-Lung-ENDOMUCIN-18m-Lymphocytic-Natural_Killer\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WIPF1 EOMES DZANK1 CITED4 UHMK1	4.11e-05	162	105	5	0321fc954ae4ad67ca438cbbc84632562d222188
ToppCell	facs-Lung-ENDOMUCIN-18m-Lymphocytic-NK_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WIPF1 EOMES DZANK1 CITED4 UHMK1	4.11e-05	162	105	5	5731f9514434296132df4bc86f78ce87b07cdeca
ToppCell	Substantia_nigra-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Igfbp2_(Igfbp2)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	NWD1 TRIM71 SCNN1A GPC2	4.26e-05	82	105	4	89aff8676f98e062d0e69b38c7184e51aa1a915e
ToppCell	Substantia_nigra-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Igfbp2_(Igfbp2)--\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	NWD1 TRIM71 SCNN1A GPC2	4.26e-05	82	105	4	6875a10abf1221b3dfd954c319b5e8e12fac1ff2
ToppCell	Substantia_nigra-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Igfbp2_(Igfbp2)-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	NWD1 TRIM71 SCNN1A GPC2	4.26e-05	82	105	4	259bb4ae0373d8352cb1c3bff08f66b89a298440
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TICRR PEAK3 EOMES FMN1 KIF18B	5.46e-05	172	105	5	ef33b5e0515c6d29fb6d9a673011c1b68ef264f3
ToppCell	droplet-Kidney-KIDNEY-30m-Endothelial-Pecam____kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRO SOX18 PRR22 SOX8 MN1	6.09e-05	176	105	5	c4d9166e5bbb7ca544107db14e4374289f5de6bd
ToppCell	droplet-Kidney-KIDNEY-30m-Endothelial-kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRO SOX18 PRR22 SOX8 MN1	6.09e-05	176	105	5	d58ef51002ea50b3037636038214bbb7454cb503
ToppCell	343B-Lymphocytic-NK_cells-Proliferating_NK_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	LDLRAD2 TAOK2 GPC2 KIF18B ARHGAP33	6.43e-05	178	105	5	c7e890cd02206c516cf1d7692ea7abc8ce746482
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CYP2A6 CYP2A7 ADRA1B SCNN1A IRX2	6.43e-05	178	105	5	f5ed4a6e3eb8056b1be1fb311021710c95bdf888
ToppCell	3'-Airway_Nasal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_acinar_cell-SMG_duct-SMG_duct_L.0.6.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SMR3A LGALS3 SMR3B CITED4 C2CD4D	6.60e-05	179	105	5	ec331b1132f965581f851a3b29e62873c4140e6c
ToppCell	10x3'2.3-week_17-19-Lymphocytic_NK-T_NK\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	HIC1 WIPF1 CEMIP2 EOMES BCL11B	6.77e-05	180	105	5	0a98d21fec67a890e75ebf0e2d23adddd77da214
ToppCell	10x3'2.3-week_17-19-Lymphocytic_NK\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	HIC1 WIPF1 CEMIP2 EOMES BCL11B	6.77e-05	180	105	5	1c8398342d3fa4d5ca9a8a63626cc497c5291446
ToppCell	10x3'2.3-week_17-19-Lymphocytic_NK-T_NK-CD56_bright_NK\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	HIC1 WIPF1 CEMIP2 EOMES BCL11B	6.77e-05	180	105	5	ddbab26b05f057bd78b78773381cd447bd2e2726
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRIN2D ADRA1B BCL11B MN1 NPAS1	6.77e-05	180	105	5	b6efdb4d319ef6f87f559acd974e5a71b06a2322
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RARB SOX18 ARHGEF25 CEMIP2 LTBP4	6.95e-05	181	105	5	4df7972f88117108698efd06b124b232f8588981
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RARB SOX18 ARHGEF25 CEMIP2 LTBP4	6.95e-05	181	105	5	cbb530566893281289026bfd93adf721decd4ca3
ToppCell	Basal\|World / shred by cell class for mouse tongue	ABCA1 BCL11B PXN AJUBA LTBP4	7.32e-05	183	105	5	c6729a207526ff4aa48176207b9353176f631fea
ToppCell	Control-Epithelial-Mesothelial\|Epithelial / Disease state, Lineage and Cell class	EPHB6 FRMD6-AS1 ZFHX4 MN1 CRB2	7.71e-05	185	105	5	0af540323c0113203ba6c1a4cb32d2fb9cf79d39
ToppCell	droplet-Skin\|droplet / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB6 NDOR1 BCL11B AJUBA IRX2	7.71e-05	185	105	5	657fd191ed160f8620d57b33820ec7222806f289
ToppCell	droplet-Liver-Hepatocytes-18m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NDOR1 RARB SOX18 TEAD1 LTBP4	7.91e-05	186	105	5	37860daeecd6d412bd3797f30496a56da667fbd1
ToppCell	droplet-Liver-Hepatocytes-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NDOR1 RARB SOX18 TEAD1 LTBP4	7.91e-05	186	105	5	60830822d3de3147816693404fd03392e04c2b8e
ToppCell	droplet-Liver-Hepatocytes-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NDOR1 RARB SOX18 TEAD1 LTBP4	7.91e-05	186	105	5	baebeffdd426ce767190ddefc857cc78e6a58d36
ToppCell	renal_medulla_nuclei-Adult_normal_reference\|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	RARB TEAD1 FMN1 CTBP2 RERE	8.74e-05	190	105	5	f1363f7806cfc4f14fbc1b0e8dac2de813a88eee
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-ventral_progenitors_and_neurons_1\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	EPHB6 GRM1 RTN1 BCL11B ZFHX4	8.74e-05	190	105	5	6e92c78799f34b31d098854503c796edb0dc7f80
ToppCell	Frontal_cortex-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Col3a1_(Mural.Rgs5Acta2.Col3a1)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	LGALS3 C1QTNF7 AJUBA GLIS1	8.89e-05	99	105	4	98c40a27432929434879c9e7283a14102f405f39
ToppCell	Frontal_cortex-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Col3a1_(Mural.Rgs5Acta2.Col3a1)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	LGALS3 C1QTNF7 AJUBA GLIS1	8.89e-05	99	105	4	d6bd8075dc7aba2034ea78b1389868282bc80a2d
ToppCell	droplet-Mammary_Gland-nan-18m-Epithelial-luminal_epithelial_cell_of_mammary_gland\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACOT1 CEMIP2 LGALS3 SCNN1A FGB	8.96e-05	191	105	5	c21e7904e06a5c90176f935f6822dbb5a1aa6755
ToppCell	Children_(3_yrs)-Epithelial-club_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CYP2A6 CYP2A7 RARB ADRA1B SCNN1A	8.96e-05	191	105	5	23776c7302cead3881b39127398f3b3e0d27885e
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-Neuronal-ventral_progenitors_and_neurons_2\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	ABCA1 RTN1 BCL11B ZFHX4 GPC2	8.96e-05	191	105	5	509d17d8ee0d028757ce0f2c9b97e5875f06f0ab
ToppCell	facs-Skin\|facs / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB6 NDOR1 LGALS3 BCL11B AJUBA	8.96e-05	191	105	5	ae524103331fa53fa82888dbb567fc36abcee7e0
ToppCell	IPF-Epithelial-Club\|World / Disease state, Lineage and Cell class	CYP2A6 CYP2A7 TEAD1 SCNN1A IRX2	8.96e-05	191	105	5	3c88a6f1d74bb3b9173cd0ea3a63c6d9570e3954
ToppCell	Control-Epithelial-Club\|Control / Disease state, Lineage and Cell class	CYP2A6 CYP2A7 TEAD1 C6orf132 SCNN1A	9.18e-05	192	105	5	d84ed1ea4a03edaa18c804f75afb03bd7b1f0e16
ToppCell	wk_08-11-Mesenchymal-Fibroblast-Mesenchymal_3\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	CYP2A6 HIC1 ZFHX4 MN1 GLIS1	9.18e-05	192	105	5	d88753b200d9c8da6716222d697ddf0a1548d6c8
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-lymphocytic-T_lymphocytic-mature_NK_T_cell\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	HIC1 CEMIP2 EOMES BCL11B GLIS1	9.18e-05	192	105	5	189477c44040cf0ee16c3932fa49fbd9e3acaa3c
ToppCell	PBMC-Mild-Myeloid-cDC-cDC-cDC_0\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ZNF385A RTN1 LGALS3 MTMR11 MN1	9.41e-05	193	105	5	6b3a2a32ec6dc96230cee4bbf03932f8a81e6683
ToppCell	PBMC-Mild-Myeloid-cDC-cDC-cDC_0\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ZNF385A RTN1 LGALS3 MTMR11 MN1	9.41e-05	193	105	5	b18c61e360f5f094f260007a56b189e2a48369e4
ToppCell	droplet-Mammary_Gland-nan-21m-Epithelial-luminal_epithelial_cell_of_mammary_gland\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACOT1 CEMIP2 C6orf132 SCNN1A IRX2	9.41e-05	193	105	5	22ebc3f586eb0aabc5785e468c88d7416c624ff4
ToppCell	droplet-Lung-nan-3m-Mesenchymal-Myofibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB6 TRO C1QTNF7 LTBP4 MN1	9.87e-05	195	105	5	d32716a12014522492becbde1088dc1106308490
ToppCell	10x5'-bone_marrow-Lymphocytic_T_CD8-Trm/em_CD8\|bone_marrow / Manually curated celltypes from each tissue	WIPF1 CEMIP2 EOMES SRRT BCL11B	9.87e-05	195	105	5	ed4e2275dac47cc9fb9c381e3f80fed0ce50b074
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-lymphocytic-T_lymphocytic-type_I_NK_T_cell\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	HIC1 GPATCH8 CEMIP2 EOMES BCL11B	9.87e-05	195	105	5	0a72b8446399807ace5b6c72f865bb40dbd9e92d
ToppCell	Healthy/Control-CD8+_Tem\|Healthy/Control / Disease group and Cell class	BCL9L WIPF1 CEMIP2 EOMES BCL11B	9.87e-05	195	105	5	f4955c176c4918052dc151c5e5249223ec428272
ToppCell	Children_(3_yrs)-Epithelial-club_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CYP2A6 CYP2A7 RARB ADRA1B SCNN1A	9.87e-05	195	105	5	dccc32fcf772e2504de7f663ef0a5bd8e23e92fc
ToppCell	droplet-Lung-nan-3m-Mesenchymal-pulmonary_interstitial_fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB6 TRO C1QTNF7 LTBP4 MN1	9.87e-05	195	105	5	b913d5df50c88a3a255f516a1aa42419c6701e1e
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRIN2D BCL11B SNRPN SHISA8 NPAS1	1.01e-04	196	105	5	7af6c5147ac859353504d19727dbe24f63a29dd4
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-PFC\|World / Primary Cells by Cluster	EPHB6 RTN1 RERE GPC2 MN1	1.04e-04	197	105	5	2c3b0072f8e1e09c77a85c6fc3133d1796932fb2
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-PFC-29\|World / Primary Cells by Cluster	EPHB6 RTN1 RERE GPC2 MN1	1.04e-04	197	105	5	c5bc0e7eb85642b270efc2ba92b13a736af22052
ToppCell	Multiple_Sclerosis-Myeloid-cDC\|Multiple_Sclerosis / Disease, Lineage and Cell Type	ZNF385A RTN1 LGALS3 MTMR11 UNC93B1	1.06e-04	198	105	5	ac139bfbf52b2feddb0c05b0708c8c9efbe119c9
ToppCell	control-HLA-DR+_CD83+_Monocyte\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ZNF385A LGALS3 MTMR11 CTBP2 UNC93B1	1.06e-04	198	105	5	35499a5231818e3432cf69b5c4a58c02f7771db8
ToppCell	distal-1-Epithelial-Club\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CYP2A6 CYP2A7 CYP2A13 C6orf132 IRX2	1.09e-04	199	105	5	8f0a72a95d0310ef2324c6975495c294b5a47cc8
ToppCell	distal-Epithelial-Club-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CYP2A6 CYP2A7 CYP2A13 C6orf132 IRX2	1.09e-04	199	105	5	685cefbe6ff5db8b578e50b5849524ac2f347d0c
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	GRIN2D BCL11B ZFHX4 MN1 NPAS1	1.11e-04	200	105	5	d0167f96314be78b6d867bbcc6e4396071d931b8
ToppCell	MS-Multiple_Sclerosis-Myeloid-cDC\|Multiple_Sclerosis / Disease, condition lineage and cell class	ZNF385A RTN1 LGALS3 MTMR11 UNC93B1	1.11e-04	200	105	5	d9e6c344c59544c87bc13d1e866491da432c9c1b
Drug	NSC35549	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	4.47e-08	22	104	5	CID000411697
Drug	2'-methoxyacetophenone	CYP2A6 CYP2A7 CYP2A13	9.26e-08	3	104	3	CID000068481
Drug	BP-9,10-oxide	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	1.35e-07	27	104	5	CID000037456
Drug	Brn 4136738	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	1.35e-07	27	104	5	CID000050331
Drug	C14845	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	1.35e-07	27	104	5	CID011954064
Drug	9-OH-BaP-4,5-oxide	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	1.63e-07	28	104	5	CID000115064
Drug	orphenadrine	CYP2A6 CYP2A13 CYP2D7 CYP2D6 GRIN2D SCNN1A	2.12e-07	56	104	6	CID000004601
Drug	19-hydroxytestosterone	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	2.35e-07	30	104	5	CID000150968
Drug	11-H-14,15-EETA	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	2.35e-07	30	104	5	CID011954058
Drug	BP-7,8-oxide	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	3.29e-07	32	104	5	CID000037455
Drug	12(13)-EpOME	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	4.52e-07	34	104	5	CID000001416
Drug	TCEO	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	4.52e-07	34	104	5	CID000028167
Drug	AC1O5XSP	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	4.52e-07	34	104	5	CID006442739
Drug	AC1L1CJI	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	5.25e-07	35	104	5	CID000001929
Drug	racemethorphan	CYP2A6 NDOR1 CYP2D7 CYP2D6 GRIN2D GRM1 SCNN1A	6.07e-07	107	104	7	CID000003008
Drug	15-H-11,12-EETA	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	6.08e-07	36	104	5	CID011954042
Drug	AC1L3NGJ	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	6.08e-07	36	104	5	CID000092121
Drug	11,14,15-THET	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	9.18e-07	39	104	5	CID006439531
Drug	hydroxynefazodone	EPHB6 CYP2D7 CYP2D6 ADRA1B	9.34e-07	17	104	4	CID000127096
Drug	debrisoquine	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6 ADRA1B	1.22e-06	75	104	6	CID000002965
Drug	11,12,15-trihydroxyeicosatrienoic acid	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	1.34e-06	42	104	5	CID006439610
Drug	polybrominated biphenyl	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	1.70e-06	44	104	5	CID000042948
Drug	naphthalene-1,2-dihydrodiol	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	1.91e-06	45	104	5	CID000000362
Drug	C14802	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	2.38e-06	47	104	5	CID011954053
Drug	nitro-L	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	2.64e-06	48	104	5	CID000006849
Drug	C14800	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	2.64e-06	48	104	5	CID011954051
Drug	19-HETE	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	2.93e-06	49	104	5	CID006439528
Drug	bromobenzene-3,4-oxide	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	2.93e-06	49	104	5	CID000108121
Drug	bromobenzene-2,3-oxide	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	3.25e-06	50	104	5	CID003036760
Drug	6-hydroxymelatonin	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	3.25e-06	50	104	5	CID000001864
Drug	1,1-dichloroethylene epoxide	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	3.25e-06	50	104	5	CID000119521
Drug	naphthalene epoxide	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	3.59e-06	51	104	5	CID000108063
Drug	9-hydroxybenzo(a)pyrene	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	4.35e-06	53	104	5	CID000028598
Drug	paraxanthine	CYP2A6 CYP2A13 CYP2D7 CYP2D6 UHMK1	4.35e-06	53	104	5	CID000004687
Drug	dichloroacetaldehyde	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	4.78e-06	54	104	5	CID000006576
Drug	chloroacetyl chloride	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	5.24e-06	55	104	5	CID000006577
Drug	acetanilide	CYP2A6 CYP2D7 CYP2D6 ACOT4 ACOT2	5.73e-06	56	104	5	CID000000904
Drug	1,2-dihydroxynaphthalene	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	6.26e-06	57	104	5	CID000011318
Drug	bromoacetaldehyde	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	6.82e-06	58	104	5	CID000105131
Drug	Sparteinum	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6 SCNN1A	7.01e-06	101	104	6	CID000003966
Drug	encainide	CYP2A6 CYP2D7 CYP2D6 SCNN1A	7.73e-06	28	104	4	CID000048040
Drug	1,1-dichloroethylene	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	8.07e-06	60	104	5	CID000006366
Drug	BP-4,5-oxide	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	8.76e-06	61	104	5	CID000037786
Drug	chlorzoxazone	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	1.03e-05	63	104	5	CID000002733
Drug	piperonyl butoxide	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	1.39e-05	67	104	5	CID000005794
Drug	propoxyphene	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	1.39e-05	67	104	5	CID000010100
Drug	sphondin	CYP2A6 CYP2D7 CYP2D6	1.49e-05	11	104	3	CID000108104
Drug	5,6-epoxyeicosatrienoic acid	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	1.50e-05	68	104	5	CID000001778
Drug	(Z) Fluvoxamine	CYP2A6 CYP2A13 CYP2D7 CYP2D6 ADRA1B	1.61e-05	69	104	5	CID000003404
Drug	8(9)-EET	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	1.61e-05	69	104	5	CID000001901
Drug	1h1q	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	1.73e-05	70	104	5	CID000001540
Drug	4-bromophenol	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	1.73e-05	70	104	5	CID000007808
Drug	1,2-dibromoethane	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	1.85e-05	71	104	5	CID000007839
Drug	16 alpha-hydroxytestosterone	CYP2A6 CYP2D7 CYP2D6	1.98e-05	12	104	3	CID000065545
Drug	carteolol	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	1.98e-05	72	104	5	CID000002583
Drug	cupreidine	CYP2D7 CYP2D6	2.07e-05	2	104	2	CID000051196
Drug	propargyl ether	CYP2A6 CYP2A13	2.07e-05	2	104	2	ctd:C531209
Drug	Hempa	CYP2A6 CYP2A13	2.07e-05	2	104	2	ctd:D006492
Drug	nicotine imine	CYP2A6 CYP2A13	2.07e-05	2	104	2	ctd:C034629
Drug	alpha-nicotyrine	CYP2A6 CYP2A13	2.07e-05	2	104	2	ctd:C008615
Drug	3-methoxyphenethylamine	CYP2D7 CYP2D6	2.07e-05	2	104	2	CID000074866
Drug	N-nitrosoguvacoline	CYP2A6 CYP2A13	2.07e-05	2	104	2	ctd:C036676
Drug	2,2,2-trichloroethanol	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	2.12e-05	73	104	5	CID000008259
Drug	chloral	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	2.12e-05	73	104	5	CID000006407
Drug	atomoxetine	CYP2D7 CYP2D6 ADRA1B VCP	2.16e-05	36	104	4	CID000054840
Drug	S-oxalylglutathione	ACOT4 UHMK1 ACOT2	2.56e-05	13	104	3	CID000168007
Drug	Sordinol	CYP2D7 CYP2D6 ADRA1B	2.56e-05	13	104	3	CID000012453
Drug	chloral hydrate	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6 GRIN2D	2.84e-05	129	104	6	CID000002707
Drug	C20H32O4	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	2.92e-05	78	104	5	CID000001440
Drug	BP-7,8-diol	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	2.92e-05	78	104	5	CID000025892
Drug	Diethylstilbestrol [56-53-1]; Up 200; 15uM; PC3; HT_HG-U133A	NDOR1 ATN1 TRO WDR25 GRM1 CTAGE1 LTBP4	3.10e-05	194	104	7	3812_UP
Drug	Lomefloxacin hydrochloride [98079-52-8]; Up 200; 10.4uM; MCF7; HT_HG-U133A	EPHB6 NDOR1 WIPF1 ETV2 GRM1 SMR3B TTLL4	3.20e-05	195	104	7	3620_UP
Drug	N-nitrosomethylaniline	CYP2A6 CYP2A7 CYP2A13	3.25e-05	14	104	3	CID000011957
Drug	trimipramine	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	3.31e-05	80	104	5	CID000005584
Drug	Trioxsalen [3902-71-4]; Up 200; 17.6uM; HL60; HT_HG-U133A	NDOR1 ATN1 TRO SMR3B SCNN1A FGB ARHGAP33	3.41e-05	197	104	7	2516_UP
Drug	Sertaconazole nitrate [99592-39-9]; Up 200; 8uM; PC3; HT_HG-U133A	ATN1 GRM1 SCNN1A FGB RERE EPN1 LTBP4	3.41e-05	197	104	7	4475_UP
Drug	bupropion	CYP2A6 CYP2D7 CYP2D6 ADRA1B SCNN1A	3.51e-05	81	104	5	CID000000444
Drug	furafylline	CYP2A6 CYP2D7 CYP2D6 TRO	3.65e-05	41	104	4	CID000003433
Drug	aminoglutethimide	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6 SNRPN	3.98e-05	137	104	6	CID000002145
Drug	isopimpinellin	CYP2A6 CYP2D7 CYP2D6	4.05e-05	15	104	3	CID000068079
Drug	aflatoxin Q1	CYP2A6 CYP2D7 CYP2D6	4.05e-05	15	104	3	CID000104757
Drug	4-hydroxymephenytoin	CYP2A6 CYP2D7 CYP2D6	4.05e-05	15	104	3	CID000119507
Drug	phenobarbital	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6 GRIN2D ACOT4 GRM1 ACOT2	4.10e-05	360	104	9	CID000004763
Drug	nefazodone	CYP2A6 CYP2D7 CYP2D6 ADRA1B	4.42e-05	43	104	4	CID000004449
Drug	Gemfibrozil	ABCA1 ACOT1 ACOT4 FGB ACOT2	4.43e-05	85	104	5	ctd:D015248
Drug	diosmetin	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	4.43e-05	85	104	5	CID005281612
Drug	sulfaphenazole	CYP2A6 CYP2D7 CYP2D6 TRO	4.85e-05	44	104	4	CID000005335
Drug	GW 6471	ABCA1 ACOT1 ACOT2	4.97e-05	16	104	3	ctd:C449302
Drug	alpha-hydroxymetoprolol	CYP2A6 CYP2D7 CYP2D6	4.97e-05	16	104	3	CID000114962
Drug	trichloroethylene	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	5.23e-05	88	104	5	CID000006575
Drug	mephenytoin	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	5.23e-05	88	104	5	CID000004060
Drug	14(15)-EpETrE	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	5.53e-05	89	104	5	CID000001431
Drug	noralfentanil	CYP2A6 CYP2D7 CYP2D6	6.01e-05	17	104	3	CID000162172
Drug	Methamphetamine	BCL9L CYP2D6 SOX18 ACOT1 GRIN2D GRM1 ARHGEF25 TAOK2 SRRT ADRA1B CITED4 TTLL4 PXN CTBP2 C1QTNF7 HDAC10 LTBP4 MN1	6.05e-05	1401	104	18	ctd:D008694
Drug	parathion	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	6.15e-05	91	104	5	CID000000991
Drug	2,4,6-trimethylbenzaldoxime	CYP2D7 CYP2D6	6.18e-05	3	104	2	CID000283782
Drug	O-demethyl encainide	CYP2D7 CYP2D6	6.18e-05	3	104	2	CID000054736
Drug	chlorpromazine N-oxide	CYP2D7 CYP2D6	6.18e-05	3	104	2	CID000443037
Drug	sulfur	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6 HMX1 GPC2	6.67e-05	219	104	7	CID000000402
Drug	tienilic acid	CYP2A6 CYP2A7 CYP2A13 CYP2D7 CYP2D6	6.82e-05	93	104	5	CID000038409
Disease	dentatorubral-pallidoluysian atrophy (implicated_via_orthology)	ATN1 RERE	1.18e-05	2	102	2	DOID:0060162 (implicated_via_orthology)
Disease	solanidine measurement	CYP2D7 CYP2D6	7.07e-05	4	102	2	EFO_0800966
Disease	lobe attachment	CYP2A13 GRM1 FMN1 TTLL4 MN1 GLIS1	8.53e-05	207	102	6	EFO_0007667
Disease	dodecadienoate (12:2) measurement	ACOT4 ACOT2	1.18e-04	5	102	2	EFO_0800572
Disease	X-16935 measurement	ACOT4 ACOT2	2.46e-04	7	102	2	EFO_0800763
Disease	X-24747 measurement	ACOT4 ACOT2	3.27e-04	8	102	2	EFO_0022135
Disease	X-17653 measurement	ACOT4 ACOT2	4.19e-04	9	102	2	EFO_0800783
Disease	melanoma-derived growth regulatory protein measurement	CYP2A6 LTBP4	6.38e-04	11	102	2	EFO_0008229
Disease	nicotine metabolite ratio	CYP2A6 CYP2A7	7.64e-04	12	102	2	EFO_0007794
Disease	undecenoylcarnitine (C11:1) measurement	ACOT4 ACOT2	9.00e-04	13	102	2	EFO_0800588
Disease	Neoplastic Cell Transformation	CYP2A13 LGALS3 PXN CTBP2	1.40e-03	139	102	4	C0007621
Disease	neurodegenerative disease (implicated_via_orthology)	BCL11B MTMR11 SCNN1A VCP	1.64e-03	145	102	4	DOID:1289 (implicated_via_orthology)
Disease	urinary metabolite measurement	CYP2D7 CYP2D6 ACOT4 ACOT2 HDAC10	1.64e-03	245	102	5	EFO_0005116
Disease	Feeding difficulties	ATN1 MN1	1.75e-03	18	102	2	C0232466
Disease	caffeine metabolite measurement	CYP2A6 CYP2A7	1.95e-03	19	102	2	EFO_0007872
Disease	Lung diseases	SCNN1A IRX2 LTBP4	2.53e-03	78	102	3	C0024115
Disease	unipolar depression, response to selective serotonin reuptake inhibitor	CYP2D7 CYP2D6	3.11e-03	24	102	2	EFO_0003761, EFO_0005658
Disease	non-high density lipoprotein cholesterol measurement	CYP2A6 ABCA1 CYP2D7 HMGXB4 FGB HELZ BAIAP2L2 DERPC	3.34e-03	713	102	8	EFO_0005689

Protein segments in the cluster

Peptide	Gene	Start	Entry
GPIKAYPRLGPPTPG	ZNF385A	236	Q96PM9
GTLFLPPEPGPFPGI	ACOT1	146	Q86TX2
LPPGGFPAAVCPPGR	EOMES	191	O95936
PCSPGPPGPVSGLRR	ARHGEF25	66	Q86VW2
RYPPGIVGVAPGGLP	CTBP2	386	P56545
TGPGFVPPPLAPIRG	CTAGE1	656	Q96RT6
GKLPPGPTPLPFIGN	CYP2A6	31	P11509
AGPEIGPSPAPPYGL	ALDH16A1	516	Q8IZ83
PLPAGPCLFGPPLAG	AJUBA	176	Q96IF1
PRPVLGGSFLGPPLP	FBXO10	381	Q9UK96
VCPPGAGGLPPPQRK	ABCA1	1476	O95477
GPPPPPPYGRLLANS	ATN1	441	P54259
GLALQPGPPGLHPFP	ATN1	976	P54259
VRGTLFLPPEPGPFP	ACOT2	206	P49753
PSPGYLGRGAPPPVE	ADRA1B	426	P35368
ALGPVPPPGQPLLGS	ARMC5	816	Q96C12
GVPPPPGISLNLPYG	DIAPH2	611	O60879
IVSTPPGGFPPPQGF	DAZAP1	266	Q96EP5
LVPLGGFLQPPGGPL	NWD1	846	Q149M9
GTLGPPPCQPPPGYA	RAI2	196	Q9Y5P3
PATPYPLLFPPVIGG	RARB	21	P10826
LAPPPPPGLFFGLGS	FMN1	951	Q68DA7
GIPAGFPAPRIGPQP	PTPN23	941	Q9H3S7
PPLGLPYPGPAGTRL	NPAS1	571	Q99742
YEGPPGAPRPLGSPL	LDLRAD2	116	Q5SZI1
LGPPFPGPPFSILSV	TRIM71	256	Q2Q1W2
PPNLPLGVPISSPGF	GPANK1	246	O95872
CPLPPGLLLPGYLGP	MTMR11	616	A4FU01
PPGFGGPRCRLPVPS	CRB2	1121	Q5IJ48
LLPLCPGPGPGPGSE	GPC2	11	Q8N158
SPGGPPLGLAPPPRY	HIC1	366	Q14526
AGPLIVPYNLPLPGG	LGALS3	111	P17931
SPGLLGPALGPPYPS	BAIAP2L2	231	Q6UXY1
GPALGPPYPSGRLTP	BAIAP2L2	236	Q6UXY1
PPQGYFGPKLPPSLG	GPATCH8	1126	Q9UKJ3
PAPPPISGGGYRARP	FGB	61	P02675
FGRVCLQPPGPPGSP	PEAK3	331	Q6ZS72
GPGPPGPCPTKRRLL	FAM214B	231	Q7L5A3
LLGPGALGLGPRPPP	HMX1	86	Q9NP08
IPYAGAAAPPLPLPG	HMGXB4	366	Q9UGU5
PVPGAYPNTGPGRRP	FOXD4	241	Q12950
GNPIRAYTPPPPLGP	HELZ	1156	P42694
PVPSPLCPEPPGYTG	KIF18B	576	Q86Y91
PPGGSPYPASPLLGR	IRX2	366	Q9BZI1
LYPPPPGLTEIPPGV	NDOR1	156	Q9UHB4
PPDCPVGGPLTFPGR	INO80E	176	Q8NBZ0
PPLPGALSPLYGVPE	PXN	171	P49023
GVPKPGLYPLGPPSF	ARHGAP33	1046	O14559
GQYGQDLLIPPPPPG	C6orf132	131	Q5T0Z8
SGVFPGPGLGPNPRP	DERPC	226	P0CG12
GRPPPLLPGGPVCKA	HDAC10	376	Q969S8
GEGRLPGTPPLFSPP	BCL11B	306	Q9C0K0
GKLPPGPTPLPFIGN	CYP2A13	31	Q16696
PVLFPGQPFGQPPLG	CPSF6	276	Q16630
GKLPPGPTPLPFIGN	CYP2A7	31	P20853
ARYPPGPLPLPGLGN	CYP2D6	31	P10635
QLRGGPPFPGPRFPG	BCL9L	591	Q86UU0
FFIPPRLPDPGGAVP	C2CD4D	51	B7Z1M9
GYVPGKVVPLRPPPP	CEMIP2	26	Q9UHN6
PGCRGPPGSPVIRGP	FRMD6-AS1	146	P0C7T7
RPPAYSPPRPGGFGL	LTBP4	1406	Q8N2S1
PTYISPLGGGPGLPP	EPN1	546	Q9Y6I3
FLLPVPGCPTGYLGP	HGSNAT	436	Q68CP4
ALLQPPPPPGYGPSA	FIGNL2	186	A6NMB9
PPYPLSQLPPGPSLG	GLIS1	166	Q8NBF1
GSPVPPIFGCRLPPP	DZANK1	231	Q9NVP4
SQTLGPAPLGPGPIP	ETV2	106	O00321
GGPGNGLRSLYPPPP	GRM1	1056	Q13255
PPPGLPCSGALRGFP	PRDM13	376	Q9H4Q3
PPAYATLGPRPSPGG	SCNN1A	641	P37088
RYICSIPGLPGPPGP	C1QTNF7	31	Q9BXJ2
PPPPGGSGVLFRGPL	MN1	666	Q10571
GPLGPGAPPPLLFLN	RTN1	571	Q16799
RLQPPPPLPFGLGGF	PRCC	76	Q92733
TQYPPGRGTPPPPVG	SNRPN	166	P63162
PPIRYGPPPQLCGPF	MIA3	1781	Q5JRA6
GPPPQLCGPFGPRPL	MIA3	1786	Q5JRA6
LCGPFGPRPLPPPFG	MIA3	1791	Q5JRA6
QEFRLPPPPGCPPGL	EPHB6	876	O15197
ESQRGPRGPYPPGPL	SMR3B	21	P02814
LFPPSLGLPPGPQPA	SHARPIN	326	Q9H0F6
PLPPTLGPPLGGCVQ	SHISA8	191	B8ZZ34
LPIPGALGPPNTGTP	TAOK2	756	Q9UL54
GTPYPRDLPGAIPPP	RERE	1496	Q9P2R6
DQYLPLGGPAPPEPG	SOX8	286	P57073
PAGLGPAQTPPYRPG	PRR12	216	Q9ULL5
PGPAQILPPGLTPGL	SRRT	771	Q9BXP5
GAVRPAVPTGGPPYP	SRRT	811	Q9BXP5
ATLFLPPGPGPFPGI	ACOT4	146	Q8N9L9
LGPPPPRQPGALAYG	CITED4	51	Q96RK1
ARYPPGPLPLPGLGN	CYP2D7	31	A0A087X1C5
PYRGPGNPVPGPLAP	PRPF8	6	Q6P2Q9
GSGARPGVPLYPPGL	PRR22	236	Q8IZ63
GGPGGGPLLPPRLLY	ZNF513	136	Q8N8E2
TAYPGLPGLPPVLLP	ZFHX4	3051	Q86UP3
PGPISGPVQIPGPFR	TPRX1	136	Q8N7U7
GPVQIPGPFRGPIPG	TPRX1	141	Q8N7U7
PQSPPERRGYPGPGL	TICRR	1431	Q7Z2Z1
PGPEPAGLGRRPCPY	UNC93B1	571	Q9H1C4
VPLFQGPLPPPGSLG	TRO	11	Q12816
KPPRGILLYGPPGTG	VCP	236	P55072
SGQPPNPPGPLITGL	ZNF398	601	Q8TD17
ESQRGPRGPYPPGPL	SMR3A	21	Q99954
GRFPPPLSPPYGPGR	SMR3A	61	Q99954
GPTPPPFPGNRGTAL	WIPF1	216	O43516
YLPPVGPRPPKGFVG	USP9Y	1546	O00507
PGLPRPLGSFPCPTP	ZNF598	651	Q86UK7
TLGTPGPYPGPLSPP	SOX18	286	P35713
GLPGIPRPTFPGAPG	TEAD1	141	P28347
GPPAGRAPAPLYVGP	WDR25	201	Q64LD2
GLGPGLLGVPPQPAY	TTLL4	66	Q14679
PGSPPGALKQFLPPG	UHMK1	46	Q8TAS1
PPTPALGGQRGPPTC	nan	21	Q6ZPA2
PPLLPGGAPLPAGLF	GRIN2D	291	O15399