Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
Domain-

ARRDC5 ARRDC2

1.90e-0475722.60.40.640
DomainArrestin_C

ARRDC5 ARRDC2

2.53e-048572IPR014752
DomainArrestin-like_N

ARRDC5 ARRDC2

4.05e-0410572IPR011021
DomainArrestin_C-like

ARRDC5 ARRDC2

4.05e-0410572IPR011022
DomainArrestin_C

ARRDC5 ARRDC2

4.05e-0410572PF02752
DomainArrestin_N

ARRDC5 ARRDC2

4.05e-0410572PF00339
DomainArrestin_C

ARRDC5 ARRDC2

4.05e-0410572SM01017
Domain-

FCSK TOP2A

1.85e-03215723.30.230.10
DomainRibosomal_S5_D2-typ_fold_subgr

FCSK TOP2A

2.03e-0322572IPR014721
DomainBRCT

ENGASE TOPBP1

2.84e-0326572PS50172
DomainBRCT_dom

ENGASE TOPBP1

3.29e-0328572IPR001357
DomainRibosomal_S5_D2-typ_fold

FCSK TOP2A

4.82e-0334572IPR020568
Pubmed

TOPBP1 recruits TOP2A to ultra-fine anaphase bridges to aid in their resolution.

TOPBP1 TOP2A

2.73e-06258225762097
Pubmed

Topoisomerase IIα represses transcription by enforcing promoter-proximal pausing.

FOS TOP2A

2.73e-06258233852840
Pubmed

Cell cycle-coupled variation in topoisomerase IIalpha mRNA is regulated by the 3'-untranslated region. Possible role of redox-sensitive protein binding in mRNA accumulation.

FOS TOP2A

8.19e-06358210986283
Pubmed

Bcl3, an IkappaB protein, stimulates activating protein-1 transactivation and cellular proliferation.

FOS BCL3

4.08e-05658210497212
Pubmed

METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6 A homeostasis.

NOP58 SRSF8 HERC1 TOP2A RYR3

4.26e-0523158536597993
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

USP34 SEPHS1 CAD TOPBP1 MAML1 TACC2

4.37e-0458858638580884
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

ENGASE USP34 PHF12 MAML1 SAC3D1 HERC1 ARRDC2 NBPF1

4.74e-04110558835748872
Pubmed

Usp12 stabilizes the T-cell receptor complex at the cell surface during signaling.

USP34 UCHL3

6.18e-042258226811477
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

CAD FAT3 HERC1 TOP2A

6.37e-0423458436243803
Pubmed

NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.

NOP58 TOP2A DHX8

6.91e-0410358332744500
Pubmed

SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity.

PIK3CA C2orf88 ANO5 TACC2 IQCN ZNF653 RYR3

7.98e-0491558732393512
Pubmed

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

PALS1 NOP58 CAD PIK3CA UCHL3 ATP1A3 TOP2A DHX8

1.04e-03124758827684187
Pubmed

Insights into the ubiquitin-proteasome system of human embryonic stem cells.

NOP58 CAD TACC2 ATP1A3

1.07e-0326958429511261
Pubmed

KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4.

CAD TACC2 DHX8

1.36e-0313058335545047
Pubmed

Integrated Transcriptome and Network Analysis Reveals Spatiotemporal Dynamics of Calvarial Suturogenesis.

CPXM2 TOP2A

1.40e-033358232640236
Pubmed

Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.

NOP58 CAD C2orf88 AGPAT1 TOP2A

1.42e-0349658531343991
GeneFamilyAlpha arrestins

ARRDC5 ARRDC2

5.75e-0563621311
CoexpressionGOTTWEIN_TARGETS_OF_KSHV_MIR_K12_11

PIK3CA FOS C2orf88 ARRDC2

1.17e-0563584M18201
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Hematopoietic|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

C19orf81 C2orf88 ANO5 MFAP3L DYRK3

3.84e-061815859dc0563453e24c9d1d975e2e0e1e272487e19908
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Hematopoietic-Megakaryocytic|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

C19orf81 C2orf88 ANO5 MFAP3L DYRK3

3.84e-0618158514c2dd946e89ba578711c2d25935b6b3d319b701
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Hematopoietic-Megakaryocytic-Megakaryocyte|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

C19orf81 C2orf88 ANO5 MFAP3L DYRK3

3.84e-06181585c5843b89f3d362e236ff76c3279518a2fdfc1f75
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Hematopoietic-Megakaryocytic-Megakaryocyte-Mega|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

C19orf81 C2orf88 ANO5 MFAP3L DYRK3

3.84e-06181585fcefb5902416c004631f4f8dd5c8f99fe3bd90bc
Diseasemultiple sclerosis symptom measurement

SEPHS1 CPXM2 ITPRID1

9.78e-0546573EFO_0803536
Diseaseabdominal adipose tissue measurement

ATP1A3 ADAMTSL3 UBOX5

1.49e-0453573EFO_0803316
DiseaseColorectal Carcinoma

FZD4 DNAH3 ACAP1 CAD PIK3CA ITPRID1 ADAMTSL3

3.94e-04702577C0009402
Diseasesusceptibility to rheumatic fever measurement

MAML1 RYR3

1.34e-0328572EFO_0008416
DiseaseVentricular Dysfunction, Left

PIK3CA ATP1A3

1.54e-0330572C0242698
Diseasegranulocyte percentage of myeloid white cells

ACAP1 MAML1 IRF8 ARRDC2

1.80e-03268574EFO_0007997

Protein segments in the cluster

PeptideGeneStartEntry
ICDPEIGGQMIMCPL

ANO5

341

Q75V66
KRAVLMGPMDPPRPC

ARID3C

321

A6NKF2
VEALDLPMPGCFRMR

DLGAP1

476

O14490
LARLGPPEPMMAECL

ACAP1

66

Q15027
EDPNPLLGDMRPRCM

ARRDC2

391

Q8TBH0
MRMEILGCPLPDPNN

CPXM2

286

Q8N436
EEEPLVLMCGPPPMI

CYB5R3

266

P00387
CEVQGMLVPPMAPTG

IQCN

826

Q9H0B3
MVLPTCPMAEFALPR

MAML1

1

Q92585
LIPGVEPREMAAMCL

NOP58

126

Q9Y2X3
MQPEVEPVCFPAMGS

C19orf81

1

C9J6K1
VPLPPLIMNCRTIME

MFAP3L

241

O75121
MPHLPVTACGLDPME

NUDT18

211

Q6ZVK8
LGMGPMATELEPLCT

FOS

311

P01100
MEGPPELYIPDMACA

ITPRID1

511

Q6ZRS4
MGDREECLSTPQPPM

ARRDC5

1

A6NEK1
ICDMQMRGTPRDLLP

HERC1

2186

Q15751
MGMIKRSPSPPEACR

IRF8

156

Q02556
SCLPAMLLDPRQAPM

NSUN5P2

31

Q63ZY6
EDQNPPCPRLSGMLM

NBPF1

1126

Q3BBV0
PCPRLSGMLMEVEEP

NBPF1

1131

Q3BBV0
MPPRILVECLLPNGM

PIK3CA

16

P42336
AVDCPGDLGTRMMPI

PALS1

36

Q8N3R9
IPPTLLMGMRPLCSA

CPT1C

291

Q8TCG5
MAPGCEPLTVRRMMD

FCSK

996

Q8N0W3
HMCMEGPGDEEVPLP

FZD4

156

Q9ULV1
PPGPVKLVMESICIM

DNAH3

2791

Q8TD57
PMQVDGEPCRLAPAM

DGKI

676

O75912
MPMPEPCELEERFAL

FMNL3

26

Q8IVF7
MDIIMGHCVGTRPPA

FAT3

1

Q8TDW7
MPSLAPDCPLLAMPE

LSMEM2

1

Q8N112
CPGMDVALRMYPLKP

ATP1A3

961

P13637
RELPRPEMPMFLGLA

ENGASE

676

Q8NFI3
MPRCPAGAMDEGPVD

BCL3

1

P20749
LMPGCELPVGTCPDM

SAC3D1

46

A6NKF1
STPGPPIEIMEMTCI

CFAP47

2546

Q6ZTR5
DQLACMMELLGMPPP

DYRK3

416

O43781
LGRRMAEFPLEPMLC

DHX8

976

Q14562
VPMCSDPEPRQEVPM

FAM120B

401

Q96EK7
IMPCPMLLPSGKVID

UBOX5

271

O94941
SRICMAIPAMAIPPL

SFXN3

231

Q9BWM7
LEPPLTAMPLGRWMC

PHF12

301

Q96QT6
MPRLGIGMDTCVIPL

SEPHS1

61

P49903
RVALSMALPCPMLPA

SLC35E2A

251

P0CK97
MSCGRPPPDVDGMIT

SRSF8

1

Q9BRL6
GMDPELLSMVPRPVC

UCHL3

36

P15374
LGEVVASCPMPGMVP

ZNF653

301

Q96CK0
LGMMEVLPGRCVPIA

AGPAT1

111

Q99943
LGMPDTVEDMCPDIP

RYR3

3091

Q15413
METAVRGMPLECPPR

SMRP1

136

Q8NCR6
GPVDSMPCLDRMPLL

TACC2

1321

O95359
EPFMPEERCLPRMAS

C2orf88

26

Q9BSF0
GITMVCAMPNTRPPI

CAD

1496

P27708
IRRLMDGEEPLPMLP

TOP2A

876

P11388
MPPEVKGPSGMACVL

WDR93

366

Q6P2C0
MLIDPVIPCGDLMAE

UGT2A3

146

Q6UWM9
PRPELNMCLLPTMVE

USP34

3111

Q70CQ2
PVPVMTGMTPLEDCV

TOPBP1

636

Q92547
PCPNVTVSEMPLIIM

WFIKKN2

516

Q8TEU8
IPLSEMMCRDLPGLP

ADAMTSL3

856

P82987
MMCRDLPGLPLVRSC

ADAMTSL3

861

P82987