Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor binding	CRTC3 LATS1 CENPF CTDP1 SOX17 FOXA1 CREBBP MED13	1.21e-04	582	52	8	GO:0140297
GeneOntologyMolecularFunction	transcription factor binding	CRTC3 LATS1 CENPF CTDP1 SOX17 NR3C2 FOXA1 CREBBP MED13	1.26e-04	753	52	9	GO:0008134
GeneOntologyMolecularFunction	cAMP response element binding protein binding	CRTC3 CREBBP	4.32e-04	12	52	2	GO:0008140
GeneOntologyMolecularFunction	general transcription initiation factor binding	CTDP1 NR3C2 CREBBP	6.20e-04	64	52	3	GO:0140296
GeneOntologyMolecularFunction	RNA polymerase II-specific DNA-binding transcription factor binding	LATS1 CTDP1 SOX17 FOXA1 CREBBP MED13	7.23e-04	417	52	6	GO:0061629
GeneOntologyBiologicalProcess	positive regulation of CREB transcription factor activity	CRTC3 TSSK4 CREBBP	1.13e-05	18	51	3	GO:0032793
GeneOntologyBiologicalProcess	inner cell mass cellular morphogenesis	LATS1 SOX17	1.80e-05	3	51	2	GO:0001828
GeneOntologyBiologicalProcess	protein localization to organelle	RANBP2 LATS1 DZIP1L HGS CEP83 CFAP58 POM121L2 F2 CREBBP PCM1 PYGO1	5.83e-05	1091	51	11	GO:0033365
GeneOntologyCellularComponent	nuclear membrane	RANBP2 CENPF DPY19L4 PUM2 PCM1 SULT1E1	2.21e-04	349	52	6	GO:0031965
GeneOntologyCellularComponent	ciliary transition fiber	CENPF CEP83	2.70e-04	10	52	2	GO:0097539
GeneOntologyCellularComponent	nuclear envelope	RANBP2 CENPF DPY19L4 PUM2 POM121L2 PCM1 SULT1E1	4.49e-04	560	52	7	GO:0005635
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION	FAM120B CREBBP MED13 SLC2A4	5.98e-05	84	36	4	M1008
Pubmed	Hypermethylation of FOXA1 and allelic loss of PTEN drive squamous differentiation and promote heterogeneity in bladder cancer.	PTEN FOXA1	2.19e-06	2	52	2	31636388
Pubmed	CBP loss cooperates with PTEN haploinsufficiency to drive prostate cancer: implications for epigenetic therapy.	PTEN CREBBP	2.19e-06	2	52	2	24491799
Pubmed	CD103-positive CSC exosome promotes EMT of clear cell renal cell carcinoma: role of remote MiR-19b-3p.	PTEN ITGAE	6.57e-06	3	52	2	30975145
Pubmed	PUM2 promoted osteoarthritis progression through PTEN-mediated chondrocyte ferroptosis by facilitating NEDD4 mRNA degradation.	PUM2 PTEN	6.57e-06	3	52	2	38733337
Pubmed	Aberrant activation of CYR61 enhancers in colorectal cancer development.	FOXA1 CREBBP	6.57e-06	3	52	2	31118064
Pubmed	A human MAP kinase interactome.	RANBP2 CRTC3 USF3 LATS1 HGS CREBBP PYGO1	7.74e-06	486	52	7	20936779
Pubmed	Association between hepatocyte nuclear factor 6 (HNF-6) and FoxA2 DNA binding domains stimulates FoxA2 transcriptional activity but inhibits HNF-6 DNA binding.	FOXA1 CREBBP	1.31e-05	4	52	2	12509444
Pubmed	Regulation of insulin signaling and glucose transporter 4 (GLUT4) exocytosis by phosphatidylinositol 3,4,5-trisphosphate (PIP3) phosphatase, skeletal muscle, and kidney enriched inositol polyphosphate phosphatase (SKIP).	PTEN SLC2A4	1.31e-05	4	52	2	22247557
Pubmed	Predicting Drug Response in Human Prostate Cancer from Preclinical Analysis of In Vivo Mouse Models.	CENPF PTEN	2.19e-05	5	52	2	26387954
Pubmed	p54nrb acts as a transcriptional coactivator for activation function 1 of the human androgen receptor.	PSPC1 CREBBP	2.19e-05	5	52	2	12810069
Pubmed	Oxidative stress-CBP axis modulates MOB1 acetylation and activates the Hippo signaling pathway.	LATS1 CREBBP	2.19e-05	5	52	2	35349706
Pubmed	Anatomy and development of the extrahepatic biliary system in mouse and rat: a perspective on the evolutionary loss of the gallbladder.	SOX17 FOXA1	2.19e-05	5	52	2	29023691
Pubmed	Lysine acetyltransferases cyclic adenosine monophosphate response element-binding binding protein and acetyltransferase p300 attenuate transcriptional activity of the mineralocorticoid receptor through its acetylation.	NR3C2 CREBBP	2.19e-05	5	52	2	25707758
Pubmed	LATS1 K751 acetylation blocks activation of Hippo signalling and switches LATS1 from a tumor suppressor to an oncoprotein.	LATS1 CREBBP	3.28e-05	6	52	2	33945069
Pubmed	Murine CENPF interacts with syntaxin 4 in the regulation of vesicular transport.	CENPF SLC2A4	3.28e-05	6	52	2	18827011
Pubmed	p34 is a novel regulator of the oncogenic behavior of NEDD4-1 and PTEN.	N4BP1 PTEN	3.28e-05	6	52	2	24141722
Pubmed	Acetylation of alpha-fetoprotein promotes hepatocellular carcinoma progression.	PTEN CREBBP	3.28e-05	6	52	2	31811908
Pubmed	Opposing roles for 53BP1 during homologous recombination.	DCLRE1C CENPF	3.28e-05	6	52	2	23969417
Pubmed	A novel PTEN/mutant p53/c-Myc/Bcl-XL axis mediates context-dependent oncogenic effects of PTEN with implications for cancer prognosis and therapy.	PTEN CREBBP	3.28e-05	6	52	2	23908595
Pubmed	Human transcription factor protein interaction networks.	HGS SOX17 AUTS2 PUM2 N4BP1 SSBP4 FOXA1 CREBBP PCM1 PYGO1	4.35e-05	1429	52	10	35140242
Pubmed	Polymorphisms of thrombophilic and vasoactive genes and severe preeclampsia: a pilot study.	NR3C2 F2	4.58e-05	7	52	2	15120696
Pubmed	Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice.	LATS1 PTEN	4.58e-05	7	52	2	31754005
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	CRTC3 WDR70 AUTS2 PUM2 PSPC1 CREBBP	6.08e-05	457	52	6	32344865
Pubmed	Cross-species regulatory network analysis identifies a synergistic interaction between FOXM1 and CENPF that drives prostate cancer malignancy.	CENPF PTEN	6.10e-05	8	52	2	24823640
Pubmed	Hrs, a FYVE finger protein localized to early endosomes, is implicated in vesicular traffic and required for ventral folding morphogenesis.	HGS FOXA1	7.84e-05	9	52	2	10364163
Pubmed	Discovering human diabetes-risk gene function with genetics and physiological assays.	ADRA2A DGKB	7.84e-05	9	52	2	30242153
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	AUTS2 PUM2 PSPC1 CREBBP	8.06e-05	152	52	4	38360978
Pubmed	The transcriptional co-repressor TLE3 suppresses basal signaling on a subset of estrogen receptor α target genes.	FOXA1 CREBBP	9.79e-05	10	52	2	25223786
Pubmed	LATS1/WARTS phosphorylates MYPT1 to counteract PLK1 and regulate mammalian mitotic progression.	LATS1 PTEN	1.20e-04	11	52	2	22641346
Pubmed	Revising the embryonic origin of thyroid C cells in mice and humans.	SOX17 FOXA1	1.20e-04	11	52	2	26395490
Pubmed	Hgs Deficiency Caused Restrictive Cardiomyopathy via Disrupting Proteostasis.	HGS AUTS2	1.20e-04	11	52	2	35342336
Pubmed	Control of thrombin signaling through PI3K is a mechanism underlying plasticity between hair follicle dermal sheath and papilla cells.	PTEN F2	1.20e-04	11	52	2	18398001
Pubmed	Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are associated with reduced glucose-stimulated beta cell function in middle-aged Danish people.	ADRA2A DGKB	1.43e-04	12	52	2	20419449
Pubmed	Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins.	DZIP1L PUM2	1.69e-04	13	52	2	12511597
Pubmed	A genetic study of the suppressors of the Engrailed-1 cerebellar phenotype.	PTEN FOXA1	1.69e-04	13	52	2	16884697
Pubmed	Temporal reduction of LATS kinases in the early preimplantation embryo prevents ICM lineage differentiation.	LATS1 SOX17	1.69e-04	13	52	2	23824537
Pubmed	TLR3 downregulates expression of schizophrenia gene Disc1 via MYD88 to control neuronal morphology.	AUTS2 PTEN	1.97e-04	14	52	2	27979975
Pubmed	A cytoplasmic role of Wnt/β-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation.	AMBN PYGO1	1.97e-04	14	52	2	28174279
Pubmed	Depletion of definitive gut endoderm in Sox17-null mutant mice.	SOX17 FOXA1	1.97e-04	14	52	2	11973269
Pubmed	C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals.	CEP83 PCM1	2.27e-04	15	52	2	24469809
Pubmed	Hindgut defects and transformation of the gastro-intestinal tract in Tcf4(-/-)/Tcf1(-/-) embryos.	SOX17 FOXA1	2.60e-04	16	52	2	15057272
Pubmed	Redundant roles of Tead1 and Tead2 in notochord development and the regulation of cell proliferation and survival.	SOX17 FOXA1	2.60e-04	16	52	2	18332127
Pubmed	Essential requirement of mammalian Pumilio family in embryonic development.	SOX17 PUM2	2.60e-04	16	52	2	30256721
Pubmed	Study of 18 functional hemostatic polymorphisms in mucocutaneous bleeding disorders.	ADRA2A F2	2.60e-04	16	52	2	20532885
Pubmed	The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics.	ADRA2A NR3C2	2.60e-04	16	52	2	15824464
Pubmed	Chfr is linked to tumour metastasis through the downregulation of HDAC1.	RANBP2 HLTF	2.60e-04	16	52	2	19182791
Pubmed	Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules.	FOXA1 CREBBP	2.60e-04	16	52	2	22780989
Pubmed	NRF1 association with AUTS2-Polycomb mediates specific gene activation in the brain.	AUTS2 CREBBP	2.94e-04	17	52	2	34637754
Pubmed	Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort.	FOXA1 CREBBP	2.94e-04	17	52	2	19183483
Pubmed	Daxx Inhibits HIV-1 Reverse Transcription and Uncoating in a SUMO-Dependent Manner.	RANBP2 CREBBP	3.69e-04	19	52	2	32545337
Pubmed	An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis.	CREBBP MED13	3.69e-04	19	52	2	16799563
Pubmed	Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling.	SOX17 PTEN	4.09e-04	20	52	2	20133625
Pubmed	New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.	ADRA2A DGKB	4.09e-04	20	52	2	20081858
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	CRTC3 LATS1 HGS COA7 PCM1	5.37e-04	446	52	5	24255178
Pubmed	Composite co-activator ARC mediates chromatin-directed transcriptional activation.	CREBBP MED13	5.44e-04	23	52	2	10235267
Pubmed	Global proteomics of Ubqln2-based murine models of ALS.	SCRN2 LATS1 HGS N4BP1	6.32e-04	261	52	4	33277362
Pubmed	A microarray minisequencing system for pharmacogenetic profiling of antihypertensive drug response.	ADRA2A NR3C2	6.43e-04	25	52	2	12544508
Pubmed	Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse.	LATS1 SOX17	6.43e-04	25	52	2	19786569
Pubmed	Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning.	SOX17 FOXA1	6.96e-04	26	52	2	25446530
Pubmed	Identification of host proteins required for HIV infection through a functional genomic screen.	RANBP2 CRTC3 HGS CTDP1	7.38e-04	272	52	4	18187620
Pubmed	Increased gene copy number of VAMP7 disrupts human male urogenital development through altered estrogen action.	CREBBP SULT1E1	8.08e-04	28	52	2	24880616
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	RANBP2 LATS1 CTDP1 PUM2 MED13 PCM1	1.02e-03	774	52	6	15302935
Pubmed	Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.	RANBP2 LATS1 PCM1	1.05e-03	133	52	3	15144186
Pubmed	HIV-1 Vpr degrades the HLTF DNA translocase in T cells and macrophages.	CENPF HLTF	1.06e-03	32	52	2	27114546
Pubmed	S100A3 a partner protein regulating the stability/activity of RARα and PML-RARα in cellular models of breast/lung cancer and acute myeloid leukemia.	CEP83 PSPC1	1.06e-03	32	52	2	30532072
Pubmed	Genome-wide analysis of translation reveals a critical role for deleted in azoospermia-like (Dazl) at the oocyte-to-zygote transition.	PUM2 PCM1	1.06e-03	32	52	2	21460039
Pubmed	Spindle Assembly Checkpoint Inhibition Can Resensitize p53-Null Stem Cells to Cancer Chemotherapy.	PGLYRP4 PUM2 NR3C2	1.15e-03	137	52	3	30862715
Pubmed	Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.	ZNF469 NR3C2	1.26e-03	35	52	2	23291589
Pubmed	Transcription Factors YAP/TAZ and SRF Cooperate To Specify Renal Myofibroblasts in the Developing Mouse Kidney.	LATS1 SOX17	1.41e-03	37	52	2	35918150
Pubmed	Enzymatic analysis of WWP2 E3 ubiquitin ligase using protein microarrays identifies autophagy-related substrates.	HGS PTEN	1.49e-03	38	52	2	35331737
Interaction	LDB1 interactions	SOX17 SSBP4 PTEN FOXA1 PYGO1	9.57e-06	115	50	5	int:LDB1
Interaction	LDB2 interactions	SSBP4 FOXA1 CREBBP PYGO1	1.12e-05	56	50	4	int:LDB2
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-smooth_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADRA2A DZIP1L TRPV2 DGKB SLC2A4	2.82e-06	190	52	5	1ab3f19f1ce9f58e5125135704d94655a2e330a0
Disease	Ductal Carcinoma	PTEN FOXA1	1.59e-04	11	51	2	C1176475
Disease	Hypertrophy	PTEN F2	4.40e-04	18	51	2	C0020564
Disease	Fatty Liver	PTEN FOXA1 F2	4.81e-04	88	51	3	C0015695
Disease	Steatohepatitis	PTEN FOXA1 F2	4.81e-04	88	51	3	C2711227
Disease	Adenocarcinoma of prostate	PTEN FOXA1	5.46e-04	20	51	2	C0007112
Disease	fasting blood glucose measurement, HOMA-B, fasting blood insulin measurement	ADRA2A DGKB	8.57e-04	25	51	2	EFO_0004465, EFO_0004466, EFO_0004469
Disease	Sezary Syndrome	PTEN CREBBP	1.00e-03	27	51	2	C0036920

Protein segments in the cluster

Peptide	Gene	Start	Entry
VYFQGTGDMNAPPGS	CTDP1	321	Q9Y5B0
GNSRNLFGQPPDMGF	CATSPERB	521	Q9H7T0
AVPFFPQQSGTPGMA	AMBN	26	Q9NP70
KMGITGNTSPFGQPF	CREBBP	266	Q92793
FGQPFSQAGGQPMGA	CREBBP	276	Q92793
FTDMDTFPNNFPPGG	CEP83	6	Q9Y592
FGKTNFVQPMPGEGL	RANBP2	1001	P49792
NPTLAFGQGLATGMP	PUM2	416	Q8TB72
GGVSLFFMPNAGPQR	DZIP1L	691	Q8IYY4
FFMPNAGPQRAATPG	DZIP1L	696	Q8IYY4
FKGNPTVNPFPFMDG	NR3C2	441	P08235
FDFTQPAGVSGMAFP	MAGED4	236	Q96JG8
SKFNFPSGRPGMQNG	LATS1	336	O95835
FSQGPRPAAMAVAGF	SLC2A4	411	P14672
NTFLMVKPNGPGFTG	CFAP58	846	Q5T655
FQIPLPEDGMQFGGS	KIAA1109	4641	Q2LD37
MAFTPSALPIGFNGV	ITGAE	686	P38570
APGMNFSPLFPSNFG	PCM1	1136	Q15154
GITFMGTFTGIPPNA	PGLYRP4	306	Q96LB8
GFFVEDNFMVGPQLP	PCED1B	366	Q96HM7
FGGLGNPSVTPNSMF	AUTS2	761	Q8WXX7
FMFYNTGAQTGPGPS	PCDHAC2	806	Q9Y5I4
PASFNMSYANPGLGA	FOXA1	61	P55317
CPGSVMFLFQGNNGT	DCLRE1C	116	Q96SD1
FSGPNALVPMDFLGN	CENPF	1751	P49454
FFPDVGFDQQSMRPG	CRTC3	496	Q6UUV7
PVAAVFAGSPQLMGA	DPY19L4	576	Q7Z388
LSGNGPMPGLNFFRD	DGKB	471	Q9Y6T7
MFGGDFPTARDPQGN	KCTD6	41	Q8NC69
EGVVPFGANNAFTMP	HLTF	131	Q14527
LAPPGGTSMFPFQNI	FTH1P19	161	P0C7X4
PGRNMFFIPSGLAVF	FAM120B	126	Q96EK7
ETIPMFSGGTCNPQF	PTEN	201	P60484
LGMGFNRPHAFNFGP	PYGO1	136	Q9Y3Y4
MDGLGLQFPEQGFPA	SOX17	176	Q9H6I2
FKPFIFGMGVAQAPQ	SCRN2	316	Q96FV2
PSFPPFGSMNSNAAG	MED13	1556	Q9UHV7
PQPFTFGGFVTPMDC	POM121L2	886	Q96KW2
GSFAPMGSLQPDAGN	ADRA2A	11	P08913
FNLSAMFLQGAPGFP	COA7	151	Q96BR5
TLTFPPGFGQFMAGQ	CLCN2	376	P51788
DFGFAKMVPSNQPVG	TSSK4	166	Q6SA08
PGSFPEFVEKFMQGQ	SULT1E1	151	P49888
AINMGDAFSPAPAGN	PSPC1	401	Q8WXF1
GPDPQLAVTMGFTGF	WDR70	16	Q9NW82
SMAAGFFQGPPGSQP	SSBP4	116	Q9BWG4
MYPAGATGAQAAPQA	HGS	636	O14964
DFGSGLPPMESQFQG	TRPV2	31	Q9Y5S1
QNFGFSFIPEGGMNP	USF3	2061	Q68DE3
NGMTDPGAQPLFFGV	ZNF469	551	Q96JG9
PGDFGAFAQLPEQPM	ZBTB7C	261	A1YPR0
FKAPVFEPGGSMQQG	UBR3	836	Q6ZT12
GDSGGPFVMKSPFNN	F2	566	P00734
GMFDPSFRVPGTQAA	N4BP1	791	O75113
PVPTRMGGFFNSGCS	NAA25	756	Q14CX7