Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	dense core granule cytoskeletal transport	TANC2 KIF1A SYBU	2.73e-06	12	49	3	GO:0099519
GeneOntologyBiologicalProcess	dense core granule transport	TANC2 KIF1A SYBU	4.50e-06	14	49	3	GO:1901950
GeneOntologyBiologicalProcess	dense core granule localization	TANC2 KIF1A SYBU	3.96e-05	28	49	3	GO:0032253
GeneOntologyBiologicalProcess	secretory granule localization	TANC2 KIF1A SYBU	7.16e-05	34	49	3	GO:0032252
GeneOntologyBiologicalProcess	anterograde neuronal dense core vesicle transport	KIF1A SYBU	1.53e-04	8	49	2	GO:1990048
Domain	Spectrin	SPTBN4 SYNE3 MACF1	3.27e-05	23	51	3	PF00435
Domain	Spectrin_repeat	SPTBN4 SYNE3 MACF1	6.67e-05	29	51	3	IPR002017
Domain	Spectrin/alpha-actinin	SPTBN4 SYNE3 MACF1	9.00e-05	32	51	3	IPR018159
Domain	SPEC	SPTBN4 SYNE3 MACF1	9.00e-05	32	51	3	SM00150
Domain	Chromodomain_CS	CBX6 CDYL	1.09e-03	18	51	2	IPR023779
Domain	Actinin_actin-bd_CS	SPTBN4 MACF1	1.78e-03	23	51	2	IPR001589
Domain	ACTININ_2	SPTBN4 MACF1	1.78e-03	23	51	2	PS00020
Domain	ACTININ_1	SPTBN4 MACF1	1.78e-03	23	51	2	PS00019
Domain	Chromo_domain	CBX6 CDYL	1.94e-03	24	51	2	IPR023780
Domain	Chromo	CBX6 CDYL	2.28e-03	26	51	2	PF00385
Domain	CHROMO_1	CBX6 CDYL	2.64e-03	28	51	2	PS00598
Domain	CHROMO_2	CBX6 CDYL	2.64e-03	28	51	2	PS50013
Domain	FHA	KIF1A CEP170B	2.64e-03	28	51	2	SM00240
Domain	FHA_DOMAIN	KIF1A CEP170B	3.23e-03	31	51	2	PS50006
Domain	FHA	KIF1A CEP170B	3.23e-03	31	51	2	PF00498
Domain	Chromodomain-like	CBX6 CDYL	3.44e-03	32	51	2	IPR016197
Domain	Chromo/shadow_dom	CBX6 CDYL	3.66e-03	33	51	2	IPR000953
Domain	CHROMO	CBX6 CDYL	3.66e-03	33	51	2	SM00298
Domain	FHA_dom	KIF1A CEP170B	4.34e-03	36	51	2	IPR000253
Domain	-	KIF1A CEP170B	4.34e-03	36	51	2	2.60.200.20
Domain	UQ_con	UBE2T BIRC6	5.08e-03	39	51	2	PF00179
Domain	UBIQUITIN_CONJUGAT_1	UBE2T BIRC6	5.34e-03	40	51	2	PS00183
Domain	UBQ-conjugat_E2	UBE2T BIRC6	5.60e-03	41	51	2	IPR000608
Domain	UBIQUITIN_CONJUGAT_2	UBE2T BIRC6	5.60e-03	41	51	2	PS50127
Domain	-	UBE2T BIRC6	8.56e-03	51	51	2	3.10.110.10
Domain	SMAD_FHA_domain	KIF1A CEP170B	8.88e-03	52	51	2	IPR008984
Domain	UBQ-conjugating_enzyme/RWD	UBE2T BIRC6	9.22e-03	53	51	2	IPR016135
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TANC2 FLII CRYBG2 HIVEP2 SYNE3 INF2 NBEAL2 WDR70 ANKHD1 BIRC6 CEP170B	4.71e-07	1105	51	11	35748872
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	TANC2 RIN1 MACF1 SYNPO BSN MTCH1 CEP170B	7.36e-07	347	51	7	17114649
Pubmed	Exon sharing of a novel human zinc-finger gene, ZIM2, and paternally expressed gene 3 (PEG3).	PEG3 ZIM2	2.11e-06	2	51	2	10708526
Pubmed	Effects of presynaptic mutations on a postsynaptic Cacna1s calcium channel colocalized with mGluR6 at mouse photoreceptor ribbon synapses.	CACNA1F BSN	2.11e-06	2	51	2	18952919
Pubmed	Microtubule actin crosslinking factor 1 promotes osteoblast differentiation by promoting β-catenin/TCF1/Runx2 signaling axis.	MACF1 RUNX2	1.26e-05	4	51	2	28621459
Pubmed	Comprehensive identification of phosphorylation sites in postsynaptic density preparations.	TANC2 MACF1 SYNPO BSN CEP170B	2.27e-05	231	51	5	16452087
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	TANC2 FLII MACF1 SYNPO BSN ALDH9A1 BIRC6 MTCH1 CEP170B	3.70e-05	1139	51	9	36417873
Pubmed	Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.	TANC2 KIF1A PEG3 MACF1	3.83e-05	128	51	4	30995482
Pubmed	Many sequence variants affecting diversity of adult human height.	DIS3L2 ETV6 RUNX2 TNXB	5.89e-05	143	51	4	18391951
Pubmed	Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network.	UBE2T TRIM41 RLIM DTX3L	6.91e-05	149	51	4	19549727
Pubmed	Fibromodulin is expressed by both chondrocytes and osteoblasts during fetal bone development.	FMOD RUNX2	7.54e-05	9	51	2	11400162
Pubmed	Genomic imprinting in Dicer1-hypomorphic mice.	RTL1 PEG3	1.15e-04	11	51	2	16575173
Pubmed	Choroid plexus mis-splicing and altered cerebrospinal fluid composition in myotonic dystrophy type 1.	INF2 DMPK	1.38e-04	12	51	2	37143315
Pubmed	YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis.	SYNPO TNXB	1.38e-04	12	51	2	10101119
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	FLII RIN1 DIS3L2 INF2 WDR70 MACF1 ALDH9A1 ANKHD1 BIRC6	1.38e-04	1353	51	9	29467282
Pubmed	Spatiotemporal disorder in the axial skeleton development of the Mesp2-null mouse: a model of spondylocostal dysostosis and spondylothoracic dysostosis.	FMOD RUNX2	1.90e-04	14	51	2	23238123
Pubmed	O-linked N-acetylglucosamine proteomics of postsynaptic density preparations using lectin weak affinity chromatography and mass spectrometry.	SYNPO BSN	1.90e-04	14	51	2	16452088
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	TANC2 SPTBN4 FLII RIN1 INF2 MACF1 SYNPO BSN CEP170B	2.10e-04	1431	51	9	37142655
Pubmed	H19 acts as a trans regulator of the imprinted gene network controlling growth in mice.	RTL1 PEG3	2.19e-04	15	51	2	19762426
Pubmed	Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes.	CRYBG2 INF2 CBX6	2.60e-04	84	51	3	15203218
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	SPTBN4 HIVEP2 KIF1A INF2 WDR70 MACF1 SYNPO POLK CEP170B	2.82e-04	1489	51	9	28611215
Pubmed	Different roles of Runx2 during early neural crest-derived bone and tooth development.	WNT10A RUNX2	2.83e-04	17	51	2	16813524
Pubmed	The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.	TANC2 KIF1A BSN CEP170B	2.98e-04	218	51	4	33378226
Pubmed	The metalloproteinase-proteoglycans ADAMTS7 and ADAMTS12 provide an innate, tendon-specific protective mechanism against heterotopic ossification.	FMOD RUNX2	3.55e-04	19	51	2	29618652
Pubmed	The transcription factors L-Sox5 and Sox6 are essential for cartilage formation.	FMOD RUNX2	3.94e-04	20	51	2	11702786
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	FLII MACF1 SYNPO MTCH1 CEP170B	4.15e-04	430	51	5	32581705
Pubmed	DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.	SPTBN4 ANKHD1	4.78e-04	22	51	2	12812986
Pubmed	Deficiency of STING Signaling in Embryonic Cerebral Cortex Leads to Neurogenic Abnormalities and Autistic-Like Behaviors.	FMOD CFAP65	4.78e-04	22	51	2	33304758
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	TANC2 SPTBN4 FLII MACF1 SYNPO BSN CEP170B	4.89e-04	963	51	7	28671696
Pubmed	Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks.	TRIM41 RLIM DTX3L	5.01e-04	105	51	3	22493164
Pubmed	Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.	FLII ALDH9A1 BIRC6 CEP170B	5.07e-04	251	51	4	29778605
Pubmed	The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair.	WDR70 ALDH9A1 ANKHD1	5.15e-04	106	51	3	31024071
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	HIVEP2 KIF1A PEG3 ETV6 MACF1 BIRC6	5.80e-04	709	51	6	22988430
Pubmed	The DNA sequence and analysis of human chromosome 14.	SYNE3 RTL1 CEP170B	5.89e-04	111	51	3	12508121
Pubmed	Interactome of the negative regulator of nuclear import BRCA1-binding protein 2.	TANC2 TEX35	6.70e-04	26	51	2	25820252
Pubmed	Fgfr2b mediated epithelial-mesenchymal interactions coordinate tooth morphogenesis and dental trigeminal axon patterning.	WNT10A RUNX2	7.78e-04	28	51	2	17951031
Pubmed	Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease.	KIF1A BSN	1.15e-03	34	51	2	25915474
Pubmed	HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP.	MACF1 MTCH1	1.15e-03	34	51	2	25925205
Pubmed	Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins.	TRIM41 ANKHD1	1.22e-03	35	51	2	27812135
Pubmed	Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing.	DMPK OGG1	1.36e-03	37	51	2	20843780
Cytoband	3p21.31	NBEAL2 BSN KLHL18	1.94e-04	100	51	3	3p21.31
Cytoband	Ensembl 112 genes in cytogenetic band chr14q32	SYNE3 IGHD INF2 RTL1 CEP170B	4.12e-04	566	51	5	chr14q32
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	SPTBN4 PEG3 DACT3 ZIM2 DMPK IL4I1	2.01e-03	1192	51	6	chr19q13
Cytoband	14q32.33	IGHD INF2 CEP170B	2.11e-03	228	51	3	14q32.33
Cytoband	2q35	WNT10A CFAP65	3.53e-03	79	51	2	2q35
Cytoband	19q13.4	PEG3 ZIM2	3.53e-03	79	51	2	19q13.4
Cytoband	Ensembl 112 genes in cytogenetic band chr3p21	NBEAL2 BSN KLHL18	5.27e-03	316	51	3	chr3p21
CoexpressionAtlas	FacebaseRNAseq_e10.5_Medial Nasal Eminence_top-relative-expression-ranked_1000	SPTBN4 CACNA1F CRYBG2 FMOD KIF1A RTL1 CBX6 MACF1 SYNPO IL4I1 KLHL18	1.35e-05	979	50	11	Facebase_RNAseq_e10.5_Medial Nasal Eminence_1000
CoexpressionAtlas	DevelopingLowerUrinaryTract_e13.5_bladder epithelial cells_emap-30875_k-means-cluster#5_top-relative-expression-ranked_500	CRYBG2 LIPH NBEAL2 DTX3L	2.63e-05	73	50	4	gudmap_developingLowerUrinaryTract_e13.5_bladder epithelial cells_500_k5
ToppCell	TCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical\|TCGA-Thryoid / Sample_Type by Project: Shred V9	FLII RIN1 INF2 LIPH SYNPO RUNX2 CEP170B	2.12e-09	194	50	7	b46c54802b8d1e0a0a17f9ed8e82eaf5e7f4849d
ToppCell	Fibroblast-C\|World / shred on cell class and cell subclass (v4)	B3GNT9 FMOD PEG3 DACT3 TNXB	2.25e-06	189	50	5	58e0400fbab5a0755504275aef5cf7986149abab
Computational	Neighborhood of MSH3	TANC2 CDYL RUNX2 DMPK KLHL18	3.04e-04	243	27	5	MORF_MSH3
Computational	Neighborhood of RUNX1	TANC2 CDYL RUNX2 KLHL18	5.24e-04	152	27	4	MORF_RUNX1
Drug	nonyl phthalate	DMPK POLK	4.92e-06	2	51	2	CID000006787
Disease	Focal Segmental Glomerulosclerosis, Not Otherwise Specified	INF2 SYNPO	9.65e-05	9	49	2	C4049702
Disease	methionine measurement	SYBU ANKHD1	8.56e-04	26	49	2	EFO_0009771
Disease	Focal glomerulosclerosis	INF2 SYNPO	1.64e-03	36	49	2	C0017668

Protein segments in the cluster

Peptide	Gene	Start	Entry
RMGPLINRPHLERVL	ALDH9A1	326	P49189
LSPLQPQLPMHRRTE	BIRC6	2146	Q9NR09
RRPDSRLLELHITMP	CTAG2	81	O75638
CHRMSRRPLPRPDPQ	CBX6	126	O95503
GSLPVRMRRRLPQLP	CEP170B	691	Q9Y4F5
LLRRHPPPQTRMLSD	DIS3L2	606	Q8IYB7
MDGHLVPRRRLLPPT	CACNA1F	1781	O60840
PEQRPLRSPLDNMIR	ETV6	196	P41212
NLTRMPGPLPRSLRE	FMOD	166	Q06828
NRLESLPPQMRRLVH	FLII	161	Q13045
RHSMSQIPPVLTPLR	CFAP65	1156	Q6ZU64
RHPTDLLAHPLPMRR	BSN	2046	Q9UPA5
CPRPFESRMPHLRLV	FAM47B	386	Q8NA70
NLSSRLRMPPLIPAE	MACF1	2036	O94854
LRMKLRSLAHPERPQ	LIPH	411	Q8WWY8
LLPRRMGHRTLASTP	OGG1	6	O15527
PGPMHRRHLLLPARV	DMPK	566	Q09013
VPSHRRVNPPTLRMK	INF2	551	Q27J81
SHTRNPRSRMPPRDL	PEG3	181	Q9GZU2
MPERRPHLPAFRTRP	KLHL18	266	O94889
LTPSPLHAVAMRSPR	DACT3	216	Q96B18
RARMGSRPRIHPLVP	CDYL	251	Q9Y232
MASHLRPPSPLLVRV	DTX3L	1	Q8TDB6
LRSMEPPEILRTHRL	CRYBG2	771	Q8N1P7
LNHPSLPPQRLMALR	IGHD	251	P01880
LRPSRRHFPRVMPLS	KIF1A	1096	Q12756
TFSPPLPRHMQEALR	IL4I1	331	Q96RQ9
PRHPRPAAQPSARRM	MTCH1	51	Q9NZJ7
PRLRPPHDNRTMVEI	RUNX2	91	Q13950
AMLRLPPEARPRNLT	RTL1	366	A6NKG5
HPALMLSPDRRGVRL	TRIM41	441	Q8WV44
TSPHLGRRRPLLRSM	RIN1	336	Q13671
NPMDPIPRHRRRANL	SYNE3	781	Q6ZMZ3
LPDRSPRPQRHIMSR	SYNPO	521	Q8N3V7
MELRHLLRPRPGLDS	NBEAL2	531	Q6ZNJ1
QRHTPLRTSLRMPRQ	TANC2	286	Q9HCD6
PVLFLTRRPLQSMPR	SWSAP1	36	Q6NVH7
MCLQRLRLTPEPHPA	B3GNT9	321	Q6UX72
LAVPAPRVSHRMQPR	ANKHD1	2126	Q8IWZ3
SRSRIPRLILRPHMP	SYBU	21	Q9NX95
ITPHALPMFREPRQR	WDR70	531	Q9NW82
ERSRSPLHPMSEIPR	RLIM	226	Q9NVW2
TLEPHPRPLLQRELM	TNXB	3696	P22105
PHPLRLRLMGVRISS	POLK	501	Q9UBT6
RLKRELHMLATEPPP	UBE2T	6	Q9NPD8
QLPRPTRGRMRIHSL	SPTBN4	106	Q9H254
SHTRNPRSRMPPRDL	ZIM2	56	Q9NZV7
PVQMARPSARHLLPR	FP248	141	Q71RG6
MPRSAPNDILDLRLP	WNT10A	36	Q9GZT5
SPFVLMSRHPRIPRL	VN1R3	281	Q9BXE9
SPRRHLSPRRDLSPM	HIVEP2	2071	P31629
LSPRRDLSPMRHLSP	HIVEP2	2076	P31629
LRLMGKTHREPQLRP	TEX35	126	Q5T0J7