Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhigh voltage-gated calcium channel activity

CACNA1A CACNA1B CACNB1

3.83e-0614453GO:0008331
GeneOntologyMolecularFunctionprotein domain specific binding

USP8 CACNB1 LDB1 ATN1 MYO7A NIPBL PICALM SH3BP2 HNRNPK TP53BP2

1.96e-058754510GO:0019904
GeneOntologyMolecularFunctionphosphoprotein binding

CACNB1 PLCG2 ZAP70 SH3BP2

1.39e-04117454GO:0051219
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity

CACNA1A CACNA1B CACNB1

1.52e-0446453GO:0005245
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity involved in regulation of cytosolic calcium levels

CACNA1A CACNA1B

1.77e-049452GO:0099511
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

CACNA1A CACNA1B

1.77e-049452GO:0099626
GeneOntologyMolecularFunctionphosphotyrosine residue binding

PLCG2 ZAP70 SH3BP2

2.06e-0451453GO:0001784
GeneOntologyMolecularFunctionSH3 domain binding

USP8 PICALM SH3BP2 TP53BP2

2.99e-04143454GO:0017124
GeneOntologyMolecularFunctionprotein phosphorylated amino acid binding

PLCG2 ZAP70 SH3BP2

5.05e-0469453GO:0045309
GeneOntologyMolecularFunctionlamin binding

PLCB1 HNRNPK

8.29e-0419452GO:0005521
GeneOntologyMolecularFunctionphosphatidylinositol phospholipase C activity

PLCB1 PLCG2

1.56e-0326452GO:0004435
GeneOntologyMolecularFunctionamyloid-beta binding

CACNA1A CACNA1B PICALM

1.57e-03102453GO:0001540
GeneOntologyMolecularFunctionphospholipase C activity

PLCB1 PLCG2

1.94e-0329452GO:0004629
GeneOntologyBiologicalProcesspositive regulation of transcription by RNA polymerase II

LRP5 MAFB GATA5 PPP2R5D LDB1 BCL9 MAP2K1 PCBP1 CREB3L4 LMX1B NIPBL HNRNPK STAT6 PYGO1

8.58e-0713904514GO:0045944
GeneOntologyBiologicalProcesscentral nervous system development

COL4A1 PLCB1 CACNA1A LRP5 MAFB ABR LDB1 ATN1 MAP2K1 LMX1B NIPBL HNRNPK TP53BP2

1.01e-0611974513GO:0007417
GeneOntologyBiologicalProcesshead development

COL4A1 ANKRD11 PLCB1 CACNA1A MAFB ABR LDB1 MAP2K1 LMX1B NIPBL HNRNPK

3.26e-069194511GO:0060322
GeneOntologyBiologicalProcesscellular response to oxygen-containing compound

PLCB1 CACNA1A LRP5 USP8 ZNF683 CACNB1 IRS4 PLCG2 GBP4 MAP2K1 HNRNPK DDR2 STAT6

8.45e-0614504513GO:1901701
GeneOntologyBiologicalProcesscerebellum morphogenesis

CACNA1A LDB1 MAP2K1 LMX1B

8.82e-0660454GO:0021587
GeneOntologyBiologicalProcesshindbrain morphogenesis

CACNA1A LDB1 MAP2K1 LMX1B

1.14e-0564454GO:0021575
GeneOntologyBiologicalProcessbrain development

COL4A1 PLCB1 CACNA1A MAFB ABR LDB1 MAP2K1 LMX1B NIPBL HNRNPK

1.26e-058594510GO:0007420
GeneOntologyBiologicalProcessembryo development

ANKRD11 PLCB1 LRP5 MAFB ABR LDB1 MAP2K1 MYO7A LMX1B NIPBL PRRC2B TP53BP2

4.15e-0514374512GO:0009790
GeneOntologyBiologicalProcesscerebellar cortex formation

CACNA1A LDB1 MAP2K1

5.54e-0534453GO:0021697
GeneOntologyBiologicalProcessresponse to nitrogen compound

PLCB1 CACNA1A CACNA1B LRP5 CACNB1 IRS4 PLCG2 MAP2K1 HNRNPK DDR2 STAT6

6.81e-0512724511GO:1901698
GeneOntologyBiologicalProcessresponse to ionomycin

PLCB1 ZNF683

6.94e-056452GO:1904636
GeneOntologyBiologicalProcesscellular response to ionomycin

PLCB1 ZNF683

6.94e-056452GO:1904637
GeneOntologyBiologicalProcessretinal blood vessel morphogenesis

COL4A1 LRP5

6.94e-056452GO:0061304
GeneOntologyBiologicalProcesshindbrain development

CACNA1A MAFB LDB1 MAP2K1 LMX1B

8.75e-05208455GO:0030902
GeneOntologyBiologicalProcesssomatic stem cell population maintenance

LRP5 LDB1 BCL9 NIPBL

8.98e-05108454GO:0035019
GeneOntologyBiologicalProcesssynapse organization

COL4A1 CACNA1A GABRG3 LRP5 CACNB1 LMX1B PICALM HNRNPK

1.03e-04685458GO:0050808
GeneOntologyBiologicalProcesspositive regulation of cellular component organization

PLCB1 CACNA1B LRP5 USP8 PLCG2 PPP2R5D ABR MAP2K1 PICALM HNRNPK DDR2

1.29e-0413664511GO:0051130
GeneOntologyBiologicalProcessdevelopmental growth

ANKRD11 PLCB1 ATN1 BCL9 LMX1B NIPBL PICALM HNRNPK DDR2

1.30e-04911459GO:0048589
GeneOntologyBiologicalProcessembryonic morphogenesis

LRP5 MAFB ABR LDB1 MAP2K1 MYO7A LMX1B NIPBL

1.36e-04713458GO:0048598
GeneOntologyBiologicalProcessresponse to peptide hormone

PLCB1 LRP5 IRS4 MAP2K1 HNRNPK DDR2 STAT6

1.38e-04530457GO:0043434
GeneOntologyBiologicalProcesscerebellar cortex morphogenesis

CACNA1A LDB1 MAP2K1

1.57e-0448453GO:0021696
GeneOntologyBiologicalProcesscellular response to peptide hormone stimulus

PLCB1 IRS4 MAP2K1 HNRNPK DDR2 STAT6

1.69e-04381456GO:0071375
GeneOntologyBiologicalProcesscell surface receptor protein tyrosine kinase signaling pathway

COL4A1 PLCB1 IRS4 PPP2R5D MAP2K1 ZAP70 DDR2 STAT6

1.87e-04747458GO:0007169
GeneOntologyBiologicalProcesscellular response to nitrogen compound

PLCB1 CACNA1A CACNB1 IRS4 MAP2K1 HNRNPK DDR2 STAT6

1.96e-04752458GO:1901699
GeneOntologyBiologicalProcessnegative regulation of cellular extravasation

PLCB1 ABR

2.07e-0410452GO:0002692
GeneOntologyBiologicalProcesscell junction organization

COL4A1 CACNA1A GABRG3 LRP5 CACNB1 LDB1 LMX1B PICALM HNRNPK

2.15e-04974459GO:0034330
GeneOntologyBiologicalProcesscerebellum development

CACNA1A LDB1 MAP2K1 LMX1B

2.37e-04139454GO:0021549
GeneOntologyBiologicalProcesshemopoiesis

PLCB1 KLF3 ZNF683 MAFB PLCG2 LDB1 PICALM ZAP70 STAT6 PYGO1

2.46e-0412234510GO:0030097
GeneOntologyBiologicalProcesscellular response to ether

PLCB1 ZNF683

2.53e-0411452GO:0071362
GeneOntologyBiologicalProcessretina vasculature morphogenesis in camera-type eye

COL4A1 LRP5

2.53e-0411452GO:0061299
GeneOntologyBiologicalProcessnegative regulation of erythrocyte differentiation

MAFB LDB1

2.53e-0411452GO:0045647
GeneOntologyBiologicalProcessgrowth

ANKRD11 PLCB1 ATN1 BCL9 LMX1B DCBLD2 NIPBL PICALM HNRNPK DDR2

2.66e-0412354510GO:0040007
GeneOntologyBiologicalProcesscollagen-activated tyrosine kinase receptor signaling pathway

COL4A1 DDR2

3.03e-0412452GO:0038063
GeneOntologyBiologicalProcessresponse to amyloid-beta

CACNA1A CACNA1B CACNB1

3.20e-0461453GO:1904645
GeneOntologyBiologicalProcessmetencephalon development

CACNA1A LDB1 MAP2K1 LMX1B

3.42e-04153454GO:0022037
GeneOntologyBiologicalProcessear morphogenesis

MAFB ABR MYO7A NIPBL

3.51e-04154454GO:0042471
GeneOntologyBiologicalProcessface development

ANKRD11 MAP2K1 NIPBL

3.52e-0463453GO:0060324
GeneOntologyBiologicalProcessneuromuscular junction development

COL4A1 LRP5 CACNB1

4.40e-0468453GO:0007528
GeneOntologyBiologicalProcessimport into cell

CACNA1A CACNA1B LRP5 SIGLEC1 PLCG2 ABR MYO7A PICALM HNRNPK

4.42e-041074459GO:0098657
GeneOntologyBiologicalProcesscerebellar cortex development

CACNA1A LDB1 MAP2K1

5.00e-0471453GO:0021695
GeneOntologyBiologicalProcessregulation of vesicle-mediated transport

CACNA1A CACNA1B PLCG2 ABR MAP2K1 PICALM HNRNPK

5.58e-04667457GO:0060627
GeneOntologyBiologicalProcessneuromuscular process controlling balance

CACNA1A ABR MYO7A

5.64e-0474453GO:0050885
GeneOntologyBiologicalProcessinositol trisphosphate metabolic process

PLCB1 PLCG2

6.20e-0417452GO:0032957
GeneOntologyBiologicalProcessresponse to lipid

PLCB1 CACNA1B USP8 ZNF683 PLCG2 ABR GBP4 MAP2K1 HNRNPK

6.23e-041126459GO:0033993
GeneOntologyBiologicalProcesscollagen-activated signaling pathway

COL4A1 DDR2

6.96e-0418452GO:0038065
GeneOntologyBiologicalProcesscerebellar Purkinje cell differentiation

CACNA1A LDB1

6.96e-0418452GO:0021702
GeneOntologyBiologicalProcesspositive regulation of cell cycle G1/S phase transition

PLCB1 PLCG2 DDR2

7.09e-0480453GO:1902808
GeneOntologyBiologicalProcessanterograde trans-synaptic signaling

PLCB1 CACNA1A CACNA1B GABRG3 USP8 CACNB1 ABR HNRNPK

8.15e-04931458GO:0098916
GeneOntologyBiologicalProcesschemical synaptic transmission

PLCB1 CACNA1A CACNA1B GABRG3 USP8 CACNB1 ABR HNRNPK

8.15e-04931458GO:0007268
GeneOntologyBiologicalProcessWnt signaling pathway

LRP5 USP8 PLCG2 LDB1 BCL9 PYGO1

8.47e-04516456GO:0016055
GeneOntologyBiologicalProcesstrans-synaptic signaling

PLCB1 CACNA1A CACNA1B GABRG3 USP8 CACNB1 ABR HNRNPK

8.61e-04939458GO:0099537
GeneOntologyBiologicalProcesscerebellar Purkinje cell layer formation

CACNA1A LDB1

8.62e-0420452GO:0021694
GeneOntologyBiologicalProcesssensory organ morphogenesis

LRP5 MAFB ABR MYO7A NIPBL

8.74e-04343455GO:0090596
GeneOntologyBiologicalProcessenzyme-linked receptor protein signaling pathway

COL4A1 PLCB1 IRS4 PPP2R5D BCL9 MAP2K1 ZAP70 DDR2 STAT6

9.03e-041186459GO:0007167
GeneOntologyBiologicalProcesscellular response to hormone stimulus

PLCB1 USP8 IRS4 MAP2K1 HNRNPK DDR2 STAT6

9.27e-04727457GO:0032870
GeneOntologyBiologicalProcesssensory organ development

COL4A1 LRP5 MAFB ABR MYO7A LMX1B NIPBL

9.50e-04730457GO:0007423
GeneOntologyBiologicalProcessresponse to ether

PLCB1 ZNF683

1.05e-0322452GO:0045472
GeneOntologyBiologicalProcesssynaptic signaling

PLCB1 CACNA1A CACNA1B GABRG3 USP8 CACNB1 ABR HNRNPK

1.11e-03976458GO:0099536
GeneOntologyBiologicalProcesspigment granule transport

MAP2K1 MYO7A

1.14e-0323452GO:0051904
GeneOntologyBiologicalProcesspositive regulation of endocytosis

PLCG2 ABR PICALM HNRNPK

1.18e-03213454GO:0045807
GeneOntologyBiologicalProcessphosphatidylinositol-mediated signaling

PLCB1 PLCG2

1.25e-0324452GO:0048015
GeneOntologyBiologicalProcessestablishment of pigment granule localization

MAP2K1 MYO7A

1.25e-0324452GO:0051905
GeneOntologyBiologicalProcesscalcium ion transmembrane import into cytosol

PLCB1 CACNA1A CACNA1B PLCG2

1.27e-03217454GO:0097553
GeneOntologyBiologicalProcessembryonic organ development

MAFB ABR LDB1 MAP2K1 MYO7A NIPBL

1.30e-03561456GO:0048568
GeneOntologyBiologicalProcesscerebellar Purkinje cell layer morphogenesis

CACNA1A LDB1

1.35e-0325452GO:0021692
GeneOntologyBiologicalProcesspositive regulation of Ras protein signal transduction

MAP2K1 PICALM

1.35e-0325452GO:0046579
GeneOntologyBiologicalProcessanimal organ morphogenesis

ANKRD11 LRP5 MAFB GATA5 ABR MAP2K1 MYO7A NIPBL STAT6

1.45e-031269459GO:0009887
GeneOntologyBiologicalProcesspigment granule localization

MAP2K1 MYO7A

1.46e-0326452GO:0051875
GeneOntologyBiologicalProcesscalcium ion transmembrane transport

PLCB1 CACNA1A CACNA1B CACNB1 PLCG2

1.58e-03392455GO:0070588
GeneOntologyBiologicalProcessresponse to hormone

PLCB1 LRP5 USP8 IRS4 MAP2K1 HNRNPK DDR2 STAT6

1.68e-031042458GO:0009725
GeneOntologyBiologicalProcessstem cell population maintenance

LRP5 LDB1 BCL9 NIPBL

1.75e-03237454GO:0019827
GeneOntologyBiologicalProcesspositive regulation of developmental growth

PLCB1 NIPBL PICALM HNRNPK

1.78e-03238454GO:0048639
GeneOntologyBiologicalProcessnegative regulation of transcription by RNA polymerase II

KLF3 MAFB GATA5 LDB1 ATN1 NIPBL HNRNPK STAT6

1.80e-031053458GO:0000122
GeneOntologyBiologicalProcessmaintenance of cell number

LRP5 LDB1 BCL9 NIPBL

1.89e-03242454GO:0098727
GeneOntologyBiologicalProcessretina vasculature development in camera-type eye

COL4A1 LRP5

1.95e-0330452GO:0061298
GeneOntologyBiologicalProcessendocytosis

LRP5 SIGLEC1 PLCG2 ABR MYO7A PICALM HNRNPK

1.95e-03827457GO:0006897
GeneOntologyBiologicalProcessregulation of neuron projection development

CACNA1A PPP2R5D MAP2K1 PICALM HNRNPK DDR2

2.03e-03612456GO:0010975
GeneOntologyBiologicalProcessimmune system development

LRP5 MAFB MAP2K1 STAT6

2.06e-03248454GO:0002520
GeneOntologyBiologicalProcesspositive regulation of dendrite extension

PICALM HNRNPK

2.08e-0331452GO:1903861
GeneOntologyBiologicalProcesscognition

ANKRD11 PLCB1 LMX1B NIPBL PICALM

2.20e-03423455GO:0050890
GeneOntologyBiologicalProcesscell differentiation in hindbrain

CACNA1A LDB1

2.21e-0332452GO:0021533
GeneOntologyCellularComponentpostsynapse

PLCB1 CACNA1A GABRG3 USP8 CACNB1 ABR MAP2K1 PCBP1 PICALM HNRNPK

3.92e-0510184410GO:0098794
GeneOntologyCellularComponentvoltage-gated calcium channel complex

CACNA1A CACNA1B CACNB1

1.24e-0446443GO:0005891
GeneOntologyCellularComponentchromatin

ANKRD11 PLCB1 KLF3 MAFB GATA5 LDB1 CREB3L4 LMX1B NIPBL HNRNPK STAT6

1.87e-0414804411GO:0000785
GeneOntologyCellularComponentglutamatergic synapse

PLCB1 CACNA1A CACNA1B USP8 CACNB1 ABR MAP2K1 HNRNPK

2.67e-04817448GO:0098978
GeneOntologyCellularComponentbeta-catenin-TCF complex

LDB1 BCL9

3.33e-0413442GO:1990907
GeneOntologyCellularComponentcalcium channel complex

CACNA1A CACNA1B CACNB1

4.88e-0473443GO:0034704
HumanPhenoHypoplastic radial head

LMX1B NIPBL

2.13e-052242HP:0003997
HumanPhenoAbnormal cheek morphology

ANKRD11 LRP5 MAFB GATA5 MAP2K1 LMX1B SH3BP2 HNRNPK

2.70e-05282248HP:0004426
HumanPhenoInability to walk

SLC19A3 PLCB1 CACNA1A CACNA1B LRP5 MAFB ATN1 LMX1B HNRNPK

3.45e-05385249HP:0002540
MousePhenoabnormal neurocranium morphology

ANKRD11 LRP5 MAFB LMX1B NIPBL SH3BP2 PRRC2B DDR2

7.64e-07269408MP:0000074
MousePhenoabnormal cranium morphology

ANKRD11 PLCB1 LRP5 MAFB MAP2K1 LMX1B NIPBL SH3BP2 PRRC2B TP53BP2 DDR2

1.17e-058134011MP:0000438
MousePhenoabnormal craniofacial bone morphology

ANKRD11 PLCB1 LRP5 MAFB MAP2K1 LMX1B NIPBL SH3BP2 PRRC2B TP53BP2 DDR2

1.38e-058274011MP:0002116
MousePhenoabnormal rhombomere morphology

MAFB LDB1 LMX1B

1.44e-0517403MP:0000933
MousePhenoabnormal neuromere morphology

MAFB LDB1 LMX1B

1.72e-0518403MP:0003208
MousePhenopostnatal lethality

COL4A1 PLCB1 CACNA1A CACNA1B LRP5 KLF3 MAFB PPP2R5D ATN1 NIPBL PICALM TP53BP2

3.23e-0510844012MP:0002082
MousePhenobuphthalmos

COL4A1 LMX1B

4.77e-054402MP:0009274
MousePhenoabsent midbrain-hindbrain boundary

LDB1 LMX1B

4.77e-054402MP:0012133
MousePhenoincreased B cell apoptosis

PLCG2 SH3BP2 STAT6

6.77e-0528403MP:0008782
MousePhenoabnormal axial skeleton morphology

ANKRD11 PLCB1 LRP5 CACNB1 MAFB MAP2K1 LMX1B DCBLD2 NIPBL SH3BP2 PRRC2B TP53BP2 DDR2

1.32e-0414584013MP:0002114
MousePhenosmall face

ANKRD11 NIPBL DDR2

1.58e-0437403MP:0030064
MousePhenoabnormal cranium size

ANKRD11 PLCB1 MAP2K1 DDR2

1.64e-0497404MP:0010031
MousePhenoabnormal rhombomere 5 morphology

MAFB LDB1

1.66e-047402MP:0012800
MousePhenoabnormal nephron morphology

SLC19A3 COL4A1 MAFB GATA5 PLCG2 LMX1B STAT6

1.81e-04426407MP:0003881
MousePhenomacrophthalmia

COL4A1 LMX1B

2.21e-048402MP:0001296
MousePhenoabnormal face size

ANKRD11 NIPBL DDR2

2.31e-0442403MP:0030063
MousePhenoabnormal craniofacial morphology

ANKRD11 PLCB1 LRP5 MAFB LDB1 MAP2K1 LMX1B NIPBL SH3BP2 PRRC2B TP53BP2 DDR2

3.13e-0413724012MP:0000428
MousePhenocraniofacial phenotype

ANKRD11 PLCB1 LRP5 MAFB LDB1 MAP2K1 LMX1B NIPBL SH3BP2 PRRC2B TP53BP2 DDR2

3.13e-0413724012MP:0005382
MousePhenodecreased IgM level

SIGLEC1 PLCG2 SH3BP2 STAT6

3.16e-04115404MP:0001806
MousePhenoabnormal B cell apoptosis

PLCG2 SH3BP2 STAT6

3.23e-0447403MP:0008781
MousePhenocircling

CACNA1A MAFB MYO7A NIPBL

3.38e-04117404MP:0001394
MousePhenoabnormal cardiovascular development

LRP5 KLF3 USP8 GATA5 LDB1 MAP2K1 DCBLD2 PRRC2B TP53BP2

3.52e-04802409MP:0002925
MousePhenoincreased heart right atrium size

KLF3 GATA5

3.54e-0410402MP:0008727
MousePhenoimpaired macrophage phagocytosis

SIGLEC1 PLCG2 SH3BP2

3.88e-0450403MP:0001798
MousePhenodecreased collagen level

COL4A1 DDR2

4.32e-0411402MP:0020254
MousePhenoreduced male fertility

PLCB1 CACNA1A MAFB ATN1 MYO7A DDR2

4.55e-04352406MP:0001922
MousePhenoabnormal osteoclast cell number

ANKRD11 LRP5 PLCG2 SH3BP2

4.75e-04128404MP:0004983
MousePhenoabnormal heart atrium size

KLF3 GATA5 NIPBL

4.87e-0454403MP:0031576
MousePhenoreduced fertility

COL4A1 PLCB1 CACNA1A MAFB GATA5 IRS4 ATN1 MYO7A DDR2

5.12e-04844409MP:0001921
MousePhenoabnormal podocyte foot process morphology

COL4A1 MAFB LMX1B

5.14e-0455403MP:0008059
MousePhenoabnormal blood circulation

COL4A1 LRP5 KLF3 MAFB GATA5 PLCG2 DCBLD2 PRRC2B TP53BP2

5.16e-04845409MP:0002128
MousePhenovascular stenosis

GATA5 MAP2K1 TP53BP2

5.42e-0456403MP:0005412
MousePhenodecreased osteoclast cell number

ANKRD11 LRP5 PLCG2

6.01e-0458403MP:0004985
MousePhenoabnormal midbrain-hindbrain boundary morphology

LDB1 LMX1B

8.19e-0415402MP:0012132
DomainPH_dom-like

PLCB1 IRS4 PLCG2 PTPN21 ABR MYO7A SH3BP2

6.56e-05426457IPR011993
DomainSH2

PLCG2 ZAP70 SH3BP2 STAT6

1.01e-04101454PF00017
DomainVDCC_a1su_IQ

CACNA1A CACNA1B

1.18e-047452IPR014873
DomainGPHH

CACNA1A CACNA1B

1.18e-047452PF16905
DomainGPHH_dom

CACNA1A CACNA1B

1.18e-047452IPR031649
DomainCa_chan_IQ

CACNA1A CACNA1B

1.18e-047452SM01062
DomainCa_chan_IQ

CACNA1A CACNA1B

1.18e-047452PF08763
DomainSH2

PLCG2 ZAP70 SH3BP2 STAT6

1.41e-04110454SM00252
DomainSH2

PLCG2 ZAP70 SH3BP2 STAT6

1.46e-04111454PS50001
DomainSH2

PLCG2 ZAP70 SH3BP2 STAT6

1.51e-04112454IPR000980
Domain-

PLCG2 ZAP70 SH3BP2 STAT6

1.51e-041124543.30.505.10
DomainVDCCAlpha1

CACNA1A CACNA1B

2.52e-0410452IPR002077
Domain-

IRS4 PLCG2 PTPN21 ABR MYO7A SH3BP2

3.31e-043914562.30.29.30
DomainPLipase_C_Pinositol-sp_Y

PLCB1 PLCG2

5.84e-0415452IPR001711
DomainEF-hand_like

PLCB1 PLCG2

5.84e-0415452PF09279
DomainPIPLC_Y_DOMAIN

PLCB1 PLCG2

5.84e-0415452PS50008
DomainPI-PLC_fam

PLCB1 PLCG2

5.84e-0415452IPR001192
DomainPLC_EF-hand-like

PLCB1 PLCG2

5.84e-0415452IPR015359
DomainPI-PLC-Y

PLCB1 PLCG2

5.84e-0415452PF00387
DomainPLCYc

PLCB1 PLCG2

5.84e-0415452SM00149
DomainPI-PLC-X

PLCB1 PLCG2

8.47e-0418452PF00388
DomainPLCXc

PLCB1 PLCG2

8.47e-0418452SM00148
DomainPIPLC_X_DOMAIN

PLCB1 PLCG2

9.46e-0419452PS50007
DomainPLipase_C_PInositol-sp_X_dom

PLCB1 PLCG2

9.46e-0419452IPR000909
DomainFA58C

DCBLD2 DDR2

1.16e-0321452SM00231
DomainFA58C_3

DCBLD2 DDR2

1.16e-0321452PS50022
DomainFA58C_1

DCBLD2 DDR2

1.16e-0321452PS01285
DomainFA58C_2

DCBLD2 DDR2

1.16e-0321452PS01286
DomainF5_F8_type_C

DCBLD2 DDR2

1.51e-0324452PF00754
DomainFA58C

DCBLD2 DDR2

1.51e-0324452IPR000421
Domain-

PLCB1 PLCG2

1.64e-03254523.20.20.190
DomainPLC-like_Pdiesterase_TIM-brl

PLCB1 PLCG2

1.64e-0325452IPR017946
DomainSH3

CACNB1 PLCG2 MYO7A TP53BP2

1.79e-03216454SM00326
DomainSH3

CACNB1 PLCG2 MYO7A TP53BP2

1.79e-03216454PS50002
DomainSH3_domain

CACNB1 PLCG2 MYO7A TP53BP2

1.91e-03220454IPR001452
DomainFERM_N

PTPN21 MYO7A

2.86e-0333452PF09379
DomainFERM_N

PTPN21 MYO7A

2.86e-0333452IPR018979
DomainTF_DNA-bd

MAFB CREB3L4

3.58e-0337452IPR008917
DomainKH_1

PCBP1 HNRNPK

3.78e-0338452PF00013
DomainC2

PLCB1 PLCG2 ABR

3.86e-03131453PF00168
Domain-

PCBP1 HNRNPK

3.97e-03394523.30.1370.10
DomainKH

PCBP1 HNRNPK

4.18e-0340452SM00322
DomainKH_dom

PCBP1 HNRNPK

4.18e-0340452IPR004087
DomainC2

PLCB1 PLCG2 ABR

4.37e-03137453SM00239
DomainPH

IRS4 PLCG2 ABR SH3BP2

4.43e-03278454SM00233
DomainPH_DOMAIN

IRS4 PLCG2 ABR SH3BP2

4.49e-03279454PS50003
DomainPH_domain

IRS4 PLCG2 ABR SH3BP2

4.55e-03280454IPR001849
DomainKH_TYPE_1

PCBP1 HNRNPK

4.60e-0342452PS50084
DomainC2

PLCB1 PLCG2 ABR

4.83e-03142453PS50004
DomainEF-hand-dom_pair

PLCB1 CACNA1B PLCG2 STAT6

4.96e-03287454IPR011992
DomainKH_dom_type_1

PCBP1 HNRNPK

5.04e-0344452IPR004088
Domain-

PLCB1 PLCG2 ABR

5.42e-031484532.60.40.150
DomainFERM_M

PTPN21 MYO7A

5.49e-0346452PF00373
Domain-

PTPN21 MYO7A

6.21e-03494521.20.80.10
DomainFERM_central

PTPN21 MYO7A

6.21e-0349452IPR019748
DomainFERM_domain

PTPN21 MYO7A

6.21e-0349452IPR000299
DomainFERM_1

PTPN21 MYO7A

6.46e-0350452PS00660
DomainFERM_2

PTPN21 MYO7A

6.46e-0350452PS00661
PathwayREACTOME_PRESYNAPTIC_DEPOLARIZATION_AND_CALCIUM_CHANNEL_OPENING

CACNA1A CACNA1B CACNB1

3.18e-0611393MM14498
PathwayREACTOME_PRESYNAPTIC_DEPOLARIZATION_AND_CALCIUM_CHANNEL_OPENING

CACNA1A CACNA1B CACNB1

3.18e-0611393M26913
PathwayKEGG_MEDICUS_REFERENCE_CXCL12_CXCR4_PKC_ERK_SIGNALING_PATHAWAY

PLCB1 PLCG2 MAP2K1

1.84e-0519393M47596
PathwayKEGG_MEDICUS_REFERENCE_CA2_ENTRY_VOLTAGE_GATED_CA2_CHANNEL

CACNA1A CACNA1B CACNB1

4.32e-0525393M47948
PathwayREACTOME_SIGNALING_BY_WNT

PLCB1 LRP5 USP8 PPP2R5D BCL9 PYGO1

4.55e-05239396MM14756
PathwayWP_WNTBETACATENIN_SIGNALING_IN_LEUKEMIA

LRP5 BCL9 PYGO1

4.87e-0526393M39407
PathwayREACTOME_TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT

LRP5 USP8 PPP2R5D BCL9 PYGO1

7.03e-05158395MM14791
PathwayPID_AR_NONGENOMIC_PATHWAY

PLCB1 PLCG2 MAP2K1

8.34e-0531393M213
PathwayREACTOME_SIGNALING_BY_WNT

PLCB1 LRP5 USP8 PPP2R5D BCL9 PYGO1

2.67e-04330396M7847
PathwayREACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES

PLCB1 CACNA1A CACNA1B GABRG3 CACNB1

2.73e-04211395MM14502
PathwayKEGG_TYPE_II_DIABETES_MELLITUS

CACNA1A CACNA1B IRS4

2.92e-0447393M19708
PathwayKEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY

CACNA1A CACNA1B

4.04e-0411392M47958
PathwayREACTOME_TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT

LRP5 USP8 PPP2R5D BCL9 PYGO1

4.30e-04233395M27099
PathwayKEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY

PLCG2 MAP2K1 ZAP70 SH3BP2

5.39e-04137394M5669
PathwayREACTOME_SIGNALING_BY_RECEPTOR_TYROSINE_KINASES

COL4A1 GABRG3 USP8 IRS4 PPP2R5D MAP2K1 STAT6

5.64e-04532397M27870
PathwayBIOCARTA_BARR_MAPK_PATHWAY

PLCB1 MAP2K1

6.65e-0414392M668
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_PLCG_ERK_SIGNALING_PATHWAY

PLCG2 MAP2K1

6.65e-0414392M47383
PathwayKEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_PLCG_ERK_SIGNALING_PATHWAY

PLCG2 MAP2K1

6.65e-0414392M47384
PathwayREACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_ASSOCIATION_WITH_CO_FACTORS

TP53BP2 BANP

6.65e-0414392MM15341
PathwayREACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_ASSOCIATION_WITH_CO_FACTORS

TP53BP2 BANP

6.65e-0414392M27638
PathwayBIOCARTA_BARR_MAPK_PATHWAY

PLCB1 MAP2K1

6.65e-0414392MM1489
PathwayBIOCARTA_CDMAC_PATHWAY

PLCB1 MAP2K1

7.65e-0415392MM1358
PathwayWP_GPR40_PATHWAY

PLCB1 PLCG2

7.65e-0415392M39526
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_PLCG_ERK_SIGNALING_PATHWAY

PLCG2 MAP2K1

7.65e-0415392M47382
PathwayREACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES

PLCB1 CACNA1A CACNA1B GABRG3 CACNB1

8.39e-04270395M15514
PathwayBIOCARTA_SPPA_PATHWAY

PLCB1 MAP2K1

8.73e-0416392M8731
PathwayBIOCARTA_CDMAC_PATHWAY

PLCB1 MAP2K1

8.73e-0416392M4388
PathwayREACTOME_SIGNALING_BY_RECEPTOR_TYROSINE_KINASES

COL4A1 USP8 IRS4 PPP2R5D MAP2K1 STAT6

9.33e-04418396MM15587
PathwayKEGG_LONG_TERM_DEPRESSION

PLCB1 CACNA1A MAP2K1

9.43e-0470393M8232
PathwayBIOCARTA_BARRESTIN_SRC_PATHWAY

PLCB1 MAP2K1

9.88e-0417392M111
PathwayBIOCARTA_BARRESTIN_SRC_PATHWAY

PLCB1 MAP2K1

9.88e-0417392MM1491
PathwayWP_DRAVET_SYNDROME_SCN1AA1783V_POINT_MUTATION_MODEL

CACNA1A CACNA1B CACNB1

1.07e-0373393MM16641
PathwayBIOCARTA_CCR3_PATHWAY

PLCB1 MAP2K1

1.24e-0319392MM1361
PathwayKEGG_MEDICUS_REFERENCE_TCR_PLCG_ITPR_SIGNALING_PATHWAY

PLCG2 ZAP70

1.24e-0319392M47733
PathwayBIOCARTA_CCR3_PATHWAY

PLCB1 MAP2K1

1.24e-0319392M9152
PathwayREACTOME_REGULATION_OF_FZD_BY_UBIQUITINATION

LRP5 USP8

1.37e-0320392MM15155
PathwayWP_FOCAL_ADHESION_PI3KAKTMTORSIGNALING

COL4A1 IRS4 PPP2R5D MAP2K1 CREB3L4

1.38e-03302395M39719
PathwayKEGG_CALCIUM_SIGNALING_PATHWAY

PLCB1 CACNA1A CACNA1B PLCG2

1.43e-03178394M2890
PathwayKEGG_MEDICUS_REFERENCE_ACH_CHRN_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 CREB3L4

1.52e-0321392M47792
PathwayKEGG_MEDICUS_REFERENCE_GNRH_GNRHR_PLCB_PKC_SIGNALING_PATHWAY

PLCB1 MAP2K1

1.52e-0321392M47638
PathwayREACTOME_REGULATION_OF_FZD_BY_UBIQUITINATION

LRP5 USP8

1.52e-0321392M27401
PathwayKEGG_MEDICUS_REFERENCE_CXCR4_GNAQ_PLCB_G_CALCINEURIN_SIGNALING_PATHWAY

PLCB1 PLCG2

1.52e-0321392M47542
PathwayWP_PKCGAMMA_CALCIUM_SIGNALING_IN_ATAXIA

PLCB1 CACNA1A

1.66e-0322392M39795
PathwayKEGG_MEDICUS_REFERENCE_E2_ER_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 CREB3L4

1.82e-0323392M47799
PathwayKEGG_MEDICUS_REFERENCE_VGCC_CA2_APOPTOTIC_PATHWAY

CACNA1A CACNA1B

1.82e-0323392M47666
PathwayWNT_SIGNALING

LRP5 BCL9 PYGO1

1.89e-0389393M5493
PathwayWP_FOCAL_ADHESION_PI3KAKTMTOR_SIGNALING_PATHWAY

COL4A1 IRS4 PPP2R5D MAP2K1 CREB3L4

1.94e-03326395MM15917
PathwayREACTOME_NEURONAL_SYSTEM

PLCB1 CACNA1A CACNA1B GABRG3 CACNB1

2.18e-03335395MM14503
PathwayREACTOME_DECTIN_2_FAMILY

MUC16 PLCG2

2.32e-0326392M27483
PathwayREACTOME_SYNTHESIS_OF_IP3_AND_IP4_IN_THE_CYTOSOL

PLCB1 PLCG2

2.32e-0326392M27053
PathwayREACTOME_FORMATION_OF_THE_BETA_CATENIN_TCF_TRANSACTIVATING_COMPLEX

BCL9 PYGO1

2.32e-0326392MM14793
PathwayWP_B_CELL_RECEPTOR_SIGNALING

PLCG2 MAP2K1 SH3BP2

2.41e-0397393M39323
PathwayWP_CANCER_PATHWAYS

COL4A1 PLCB1 LRP5 PLCG2 MAP2K1 STAT6

2.50e-03507396M48302
PathwayREACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES

PLCG2 ZAP70

2.51e-0327392MM14809
PathwayREACTOME_SYNTHESIS_OF_IP3_AND_IP4_IN_THE_CYTOSOL

PLCB1 PLCG2

2.69e-0328392MM14711
PathwayKEGG_MEDICUS_REFERENCE_ANGIOTENSIN_ALDOSTERONE_SIGNALING_PATHWAY

PLCB1 CREB3L4

2.69e-0328392M47508
PathwayKEGG_MELANOGENESIS

PLCB1 MAP2K1 CREB3L4

2.71e-03101393M7761
PathwayWP_1Q211_COPY_NUMBER_VARIATION_SYNDROME

BCL9 PYGO1

2.89e-0329392M39890
PathwayWP_PDGFRBETA_PATHWAY

MAP2K1 STAT6

2.89e-0329392M39616
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

PLCB1 CACNA1A CACNB1 PPP2R5D ABR LDB1 BCL9 PCBP1 NIPBL PICALM HNRNPK PRRC2B TP53BP2

1.67e-10963451328671696
Pubmed

beta subunit reshuffling modifies N- and P/Q-type Ca2+ channel subunit compositions in lethargic mouse brain.

CACNA1A CACNA1B CACNB1

4.04e-08645310328888
Pubmed

Regulation of NK cell-mediated cytotoxicity by the adaptor protein 3BP2.

PLCG2 ZAP70 SH3BP2

1.13e-07845311390470
Pubmed

Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.

CACNA1A CACNA1B CACNB1

9.11e-071545320188150
Pubmed

Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.

CACNA1A CACNA1B CACNB1

9.11e-071545324453333
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

PLCB1 MUC16 USP8 DNAH12 BCL9 MYO7A NIPBL PRRC2B

1.45e-0663845831182584
Pubmed

Stable respiratory activity requires both P/Q-type and N-type voltage-gated calcium channels.

CACNA1A CACNA1B

1.64e-06245223426690
Pubmed

A dominant-negative mutation of mouse Lmx1b causes glaucoma and is semi-lethal via LDB1-mediated dimerization [corrected].

LDB1 LMX1B

1.64e-06245224809698
Pubmed

Synthetic Aβ oligomers (Aβ(1-42) globulomer) modulate presynaptic calcium currents: prevention of Aβ-induced synaptic deficits by calcium channel blockers.

CACNA1A CACNA1B

1.64e-06245223376566
Pubmed

Novel Cav2.1 splice variants isolated from Purkinje cells do not generate P-type Ca2+ current.

CACNA1A CACNB1

1.64e-06245211756409
Pubmed

Tissue specific expression and cDNA structure of a human transcript encoding a nucleic acid binding [oligo(dC)] protein related to the pre-mRNA binding protein K.

PCBP1 HNRNPK

1.64e-0624528152927
Pubmed

Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex.

BCL9 PYGO1

1.64e-06245218498752
Pubmed

CaV 2.1 α1  subunit motifs that control presynaptic CaV 2.1 subtype abundance are distinct from CaV 2.1 preference.

CACNA1A CACNA1B

1.64e-06245238155373
Pubmed

Cloning and expression of a cardiac/brain beta subunit of the L-type calcium channel.

CACNA1A CACNB1

1.64e-0624521370480
Pubmed

Confirmation of CLIM2/LMX1B interaction by yeast two-hybrid screening and analysis of its involvement in nail-patella syndrome.

LDB1 LMX1B

1.64e-06245212792813
Pubmed

LMX1B transactivation and expression in nail-patella syndrome.

LDB1 LMX1B

1.64e-06245210767331
Pubmed

Expression analysis of P/Q-type Ca2+ channel alpha 1A subunit mRNA in olfactory mitral cell in N-type Ca2+ channel alpha 1B subunit gene-deficient mice.

CACNA1A CACNA1B

1.64e-06245215050706
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

USP8 IRS4 AFTPH PCBP1 NIPBL PICALM HNRNPK PRRC2B TP53BP2

2.60e-0693445933916271
Pubmed

Pygopus residues required for its binding to Legless are critical for transcription and development.

BCL9 PYGO1

4.91e-06345214612447
Pubmed

Munc13-3 Is Required for the Developmental Localization of Ca2+ Channels to Active Zones and the Nanopositioning of Cav2.1 Near Release Sensors.

CACNA1A CACNA1B

4.91e-06345229466725
Pubmed

Ankyrin-B regulates Cav2.1 and Cav2.2 channel expression and targeting.

CACNA1A CACNA1B

4.91e-06345224394417
Pubmed

The intracellular C-terminus confers compartment-specific targeting of voltage-gated calcium channels.

CACNA1A CACNA1B

4.91e-06345238996073
Pubmed

The podocyte-specific inactivation of Lmx1b, Ldb1 and E2a yields new insight into a transcriptional network in podocytes.

LDB1 LMX1B

4.91e-06345217316599
Pubmed

MEK1/2 Inhibition Promotes Macrophage Reparative Properties.

MAP2K1 STAT6

4.91e-06345228003382
Pubmed

SH3BP2 mutations potentiate osteoclastogenesis via PLCγ.

PLCG2 SH3BP2

4.91e-06345220872577
Pubmed

Post-Transcriptional Regulation of the Human Mu-Opioid Receptor (MOR) by Morphine-Induced RNA Binding Proteins hnRNP K and PCBP1.

PCBP1 HNRNPK

4.91e-06345227292014
Pubmed

Assignment of human KH-box-containing genes by in situ hybridization: HNRNPK maps to 9q21.32-q21.33, PCBP1 to 2p12-p13, and PCBP2 to 12q13.12-q13.13, distal to FRA12A.

PCBP1 HNRNPK

4.91e-0634528833161
Pubmed

Distinct roles for Cav2.1-2.3 in activity-dependent synaptic dynamics.

CACNA1A CACNA1B

4.91e-06345224523520
Pubmed

Molecular moieties masking Ca2+-dependent facilitation of voltage-gated Cav2.2 Ca2+ channels.

CACNA1A CACNA1B

4.91e-06345229208674
Pubmed

Molecular architecture of CAG repeats in human disease related transcripts.

CACNA1A ATN1

4.91e-06345215223312
Pubmed

Molecular Basis of Regulating High Voltage-Activated Calcium Channels by S-Nitrosylation.

CACNA1A CACNA1B

4.91e-06345226507659
Pubmed

Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta.

ABR BCL9 NIPBL PRRC2B

5.76e-069045415033168
Pubmed

A quantitative protein interaction network for the ErbB receptors using protein microarrays.

IRS4 PLCG2 ZAP70 SH3BP2

5.76e-069045416273093
Pubmed

Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation.

LRP5 PPP2R5D BCL9 PYGO1

5.76e-069045419515997
Pubmed

Interaction network of human early embryonic transcription factors.

KLF3 LDB1 ATN1 BCL9 NIPBL PRRC2B

5.92e-0635145638297188
Pubmed

Bcl2L13 is a ceramide synthase inhibitor in glioblastoma.

BCL9 PCBP1 HNRNPK

9.78e-063245324706805
Pubmed

Synapse and Active Zone Assembly in the Absence of Presynaptic Ca2+ Channels and Ca2+ Entry.

CACNA1A CACNA1B

9.81e-06445232616470
Pubmed

Constitutive and ghrelin-dependent GHSR1a activation impairs CaV2.1 and CaV2.2 currents in hypothalamic neurons.

CACNA1A CACNA1B

9.81e-06445226283199
Pubmed

A strategy for fine-structure functional analysis of a 6- to 11-centimorgan region of mouse chromosome 7 by high-efficiency mutagenesis.

MYO7A PICALM

9.81e-0644522300582
Pubmed

The transcription factor MafB promotes anti-inflammatory M2 polarization and cholesterol efflux in macrophages.

MAFB STAT6

9.81e-06445228790455
Pubmed

A protein phosphatase 2calpha-Ca2+ channel complex for dephosphorylation of neuronal Ca2+ channels phosphorylated by protein kinase C.

CACNA1A CACNA1B

9.81e-06445215728831
Pubmed

CNS expression pattern of Lmx1b and coexpression with ptx genes suggest functional cooperativity in the development of forebrain motor control systems.

LDB1 LMX1B

9.81e-06445212498783
Pubmed

53BP2S, interacting with insulin receptor substrates, modulates insulin signaling.

IRS4 TP53BP2

9.81e-06445217965023
Pubmed

The MAP1B-LC1/UBE2L3 complex catalyzes degradation of cell surface CaV2.2 channels.

CACNA1A CACNA1B

9.81e-06445225483588
Pubmed

Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex.

BCL9 PYGO1

9.81e-06445211955446
Pubmed

Cerebellar granule cell signaling is indispensable for normal motor performance.

CACNA1A CACNA1B

9.81e-06445237141091
Pubmed

Interactions of Rabconnectin-3 with Cav2 calcium channels.

CACNA1A CACNA1B

9.81e-06445231253182
Pubmed

G protein-gated inhibitory module of N-type (ca(v)2.2) ca2+ channels.

CACNA1A CACNA1B

9.81e-06445215953418
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

ANKRD11 LRP5 EML2 ABR BCL9 MYO7A LMX1B PRRC2B BANP

1.01e-05110545935748872
Pubmed

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.

CACNB1 LDB1 ATN1 PCBP1 HNRNPK PRRC2B TP53BP2

1.23e-0560845716713569
Pubmed

Ion channel expression in the developing enteric nervous system.

CACNA1A CACNA1B CACNB1

1.52e-053745325798587
Pubmed

Chromosomal localization of the human genes for alpha 1A, alpha 1B, and alpha 1E voltage-dependent Ca2+ channel subunits.

CACNA1A CACNA1B

1.63e-0554528825650
Pubmed

Identification of a cardiac isoform of the murine calcium channel alpha1C (Cav1.2-a) subunit and its preferential binding with the beta2 subunit.

CACNA1A CACNA1B

1.63e-05545216787652
Pubmed

TBX3 acts as tissue-specific component of the Wnt/β-catenin transcriptional complex.

BCL9 PYGO1

1.63e-05545232808927
Pubmed

Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice.

CACNA1A CACNA1B

1.63e-05545215451373
Pubmed

Bcl9 and Pygo synergise downstream of Apc to effect intestinal neoplasia in FAP mouse models.

BCL9 PYGO1

1.63e-05545230760710
Pubmed

Functional disorders of the sympathetic nervous system in mice lacking the alpha 1B subunit (Cav 2.2) of N-type calcium channels.

CACNA1A CACNA1B

1.63e-05545211296258
Pubmed

Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.

CACNA1A CACNA1B CACNB1

1.65e-053845330786075
Pubmed

Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha.

PLCB1 PLCG2 MAP2K1

1.65e-053845312482669
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

IRS4 AFTPH ATN1 BCL9 PICALM TP53BP2

1.87e-0543045635044719
Pubmed

Voltage-gated calcium channels in developing GnRH-1 neuronal system in the mouse.

CACNA1B CACNB1

2.45e-05645216029198
Pubmed

Expression and immunohistochemical localization of eight phospholipase C isoforms in adult male mouse cerebellar cortex.

PLCB1 PLCG2

2.45e-0564528739298
Pubmed

RNA-binding proteins heterogeneous nuclear ribonucleoprotein A1, E1, and K are involved in post-transcriptional control of collagen I and III synthesis.

PCBP1 HNRNPK

2.45e-05645215514164
Pubmed

An action potential initiation mechanism in distal axons for the control of dopamine release.

CACNA1A CACNA1B

2.45e-05645235324301
Pubmed

Jerky/Earthbound facilitates cell-specific Wnt/Wingless signalling by modulating β-catenin-TCF activity.

BCL9 PYGO1

2.45e-05645221399610
Pubmed

Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis.

CACNA1A CACNA1B

2.45e-05645212827191
Pubmed

Purification and characterization of membrane-bound phospholipase C specific for phosphoinositides from human platelets.

PLCB1 PLCG2

2.45e-0564522841328
Pubmed

Role of a BCL9-related beta-catenin-binding protein, B9L, in tumorigenesis induced by aberrant activation of Wnt signaling.

BCL9 PYGO1

2.45e-05645215574752
Pubmed

Dickkopf-related protein 1 (Dkk1) regulates the accumulation and function of myeloid derived suppressor cells in cancer.

LRP5 PLCG2

2.45e-05645227045006
Pubmed

Pax6-dependent, but β-catenin-independent, function of Bcl9 proteins in mouse lens development.

BCL9 PYGO1

2.45e-05645225184676
Pubmed

A β-amyloid oligomer directly modulates P/Q-type calcium currents in Xenopus oocytes.

CACNA1A CACNB1

2.45e-05645221883149
Pubmed

Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors.

CACNA1A CACNA1B

2.45e-0564529238069
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

LDB1 ATN1 BCL9 NIPBL PRRC2B

2.49e-0526845533640491
Pubmed

Islet α-, β-, and δ-cell development is controlled by the Ldb1 coregulator, acting primarily with the islet-1 transcription factor.

MAFB LDB1 LMX1B

2.76e-054545323193182
Pubmed

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells.

ZAP70 STAT6

3.42e-05745220118929
Pubmed

Mutations in Bcl9 and Pygo genes cause congenital heart defects by tissue-specific perturbation of Wnt/β-catenin signaling.

BCL9 PYGO1

3.42e-05745230366904
Pubmed

Genetic testing in spinocerebellar ataxia in Taiwan: expansions of trinucleotide repeats in SCA8 and SCA17 are associated with typical Parkinson's disease.

CACNA1A ATN1

3.42e-05745214756671
Pubmed

Rebuilding essential active zone functions within a synapse.

CACNA1A CACNA1B

3.42e-05745235176221
Pubmed

Fate-mapping analysis of cochlear cells expressing Atoh1 mRNA via a new Atoh13*HA-P2A-Cre knockin mouse strain.

MAFB MYO7A

3.42e-05745235038200
Pubmed

Direct evidence for the action of phosphatidylinositol (3,4,5)-trisphosphate-mediated signal transduction in the 2-cell mouse embryo.

PLCB1 PLCG2

3.42e-05745217634444
Pubmed

Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts.

LRP5 MAP2K1

3.42e-05745223945236
Pubmed

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.

LDB1 ATN1 BCL9 PRRC2B

4.54e-0515245438360978
Pubmed

N-ethyl-N-nitrosourea mutagenesis of a 6- to 11-cM subregion of the Fah-Hbb interval of mouse chromosome 7: Completed testing of 4557 gametes and deletion mapping and complementation analysis of 31 mutations.

MYO7A PICALM

4.56e-05845210224267
Pubmed

Adaptor function for the Syk kinases-interacting protein 3BP2 in IL-2 gene activation.

ZAP70 SH3BP2

4.56e-0584529846481
Pubmed

The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation.

PPP2R5D MAP2K1

4.56e-05845219029245
Pubmed

Constitutive scaffolding of multiple Wnt enhanceosome components by Legless/BCL9.

LDB1 BCL9

4.56e-05845228296634
Pubmed

Identification of a heterogeneous nuclear ribonucleoprotein-recognition region in the HIV Rev protein.

PCBP1 HNRNPK

4.56e-05845219808671
Pubmed

Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line.

PLCB1 PLCG2

5.86e-0594527589147
Pubmed

The Prader-Willi syndrome proteins MAGEL2 and necdin regulate leptin receptor cell surface abundance through ubiquitination pathways.

USP8 IRS4

5.86e-05945228973533
Pubmed

International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.

CACNA1A CACNA1B

5.86e-05945216382099
Pubmed

Genetics of dizziness: cerebellar and vestibular disorders.

CACNA1A MYO7A

5.86e-05945224275721
Pubmed

Lmx1a and Lmx1b are Redundantly Required for the Development of Multiple Components of the Mammalian Auditory System.

MYO7A LMX1B

5.86e-05945233246067
Pubmed

Positive regulation of Raf1-MEK1/2-ERK1/2 signaling by protein serine/threonine phosphatase 2A holoenzymes.

PPP2R5D MAP2K1

5.86e-05945216239230
Pubmed

Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat.

PLCB1 PLCG2

5.86e-05945210501179
Pubmed

Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors.

CACNA1A KLF3 MAFB

6.58e-056045332027825
Pubmed

Novel ENU-induced eye mutations in the mouse: models for human eye disease.

COL4A1 LMX1B

7.32e-051045211929848
Pubmed

Expression of phospholipase C isozymes by murine B lymphocytes.

PLCB1 PLCG2

7.32e-05104522033248
Pubmed

Screening for premutation in the FMR1 gene in male patients suspected of spinocerebellar ataxia.

CACNA1A ATN1

7.32e-051045219235102
Pubmed

Human transcription factor protein interaction networks.

KLF3 IRS4 LDB1 ATN1 BCL9 NIPBL PRRC2B BANP PYGO1

7.57e-05142945935140242
Pubmed

USP9X-mediated deubiquitination of B-cell CLL/lymphoma 9 potentiates Wnt signaling and promotes breast carcinogenesis.

BCL9 PYGO1

8.94e-051145231073027
InteractionLHX8 interactions

KLF3 PLCG2 LDB1 BCL9 BANP PYGO1

1.86e-0953456int:LHX8
InteractionISL1 interactions

MAFB PLCG2 LDB1 BCL9 PYGO1

3.12e-0841455int:ISL1
InteractionCACNB1 interactions

CACNA1A CACNA1B CACNB1 ATN1

2.65e-0725454int:CACNB1
InteractionCRX interactions

LDB1 ATN1 BCL9 NIPBL PICALM PRRC2B BANP

1.40e-06254457int:CRX
InteractionISL2 interactions

LDB1 BCL9 LMX1B PYGO1

2.07e-0641454int:ISL2
InteractionLHX6 interactions

KLF3 LDB1 BCL9 LMX1B

8.43e-0658454int:LHX6
InteractionSSBP4 interactions

LDB1 BCL9 LMX1B PYGO1

9.02e-0659454int:SSBP4
InteractionCACNB2 interactions

CACNA1A CACNA1B CACNB1

1.79e-0523453int:CACNB2
InteractionTSPOAP1 interactions

ANKRD11 CACNA1A PPP2R5D

2.31e-0525453int:TSPOAP1
InteractionWWP1 interactions

PTPN21 ATN1 PCBP1 HNRNPK TP53BP2 STAT6

2.33e-05260456int:WWP1
InteractionPLCG1 interactions

IRS4 PLCG2 PICALM ZAP70 SH3BP2 HNRNPK

2.53e-05264456int:PLCG1
InteractionLMO4 interactions

LDB1 BCL9 TP53BP2 BANP PYGO1

2.72e-05159455int:LMO4
InteractionPYGO1 interactions

LDB1 BCL9 PYGO1

3.28e-0528453int:PYGO1
InteractionLHX4 interactions

LDB1 BCL9 TP53BP2 BANP PYGO1

3.34e-05166455int:LHX4
InteractionIRF4 interactions

LDB1 NIPBL PRRC2B STAT6

3.85e-0585454int:IRF4
InteractionEGR2 interactions

LDB1 ATN1 BCL9 NIPBL PRRC2B

3.85e-05171455int:EGR2
InteractionTLX1 interactions

LDB1 ATN1 BCL9 NIPBL PYGO1

4.30e-05175455int:TLX1
InteractionCACNB3 interactions

CACNA1A CACNA1B CACNB1

4.93e-0532453int:CACNB3
InteractionNOTO interactions

ANKRD11 HNRNPK BANP

5.42e-0533453int:NOTO
InteractionERBB4 interactions

USP8 PLCG2 PTPN21 ZAP70 SH3BP2

5.46e-05184455int:ERBB4
InteractionSP7 interactions

LDB1 ATN1 BCL9 NIPBL PRRC2B PYGO1

5.57e-05304456int:SP7
InteractionCTNNB1 interactions

LRP5 USP8 GATA5 BCL9 PCBP1 MYO7A HNRNPK TP53BP2 DDR2 PYGO1

6.08e-0510094510int:CTNNB1
InteractionHNF1B interactions

LDB1 BCL9 PCBP1 NIPBL PRRC2B

6.36e-05190455int:HNF1B
InteractionCACNA1B interactions

CACNA1A CACNA1B CACNB1

7.67e-0537453int:CACNA1B
InteractionSSBP2 interactions

LDB1 BCL9 LMX1B PYGO1

8.80e-05105454int:SSBP2
InteractionSRC interactions

ANKRD11 USP8 PTPN21 MAP2K1 SH3BP2 HNRNPK DDR2 STAT6

9.76e-05664458int:SRC
InteractionPAX8 interactions

LDB1 BCL9 NIPBL PRRC2B

1.09e-04111454int:PAX8
InteractionCBLB interactions

PLCG2 ZAP70 HNRNPK DDR2

1.25e-04115454int:CBLB
InteractionLDB1 interactions

LDB1 BCL9 LMX1B PYGO1

1.25e-04115454int:LDB1
InteractionTBXT interactions

LDB1 ATN1 BCL9 NIPBL

1.29e-04116454int:TBXT
InteractionLAT interactions

SLC19A3 PLCG2 ZAP70 SH3BP2

1.34e-04117454int:LAT
InteractionERG interactions

LDB1 BCL9 PCBP1 NIPBL PRRC2B

1.35e-04223455int:ERG
InteractionSSBP3 interactions

LDB1 BCL9 LMX1B PYGO1

1.43e-04119454int:SSBP3
InteractionRASD1 interactions

PTPN21 HNRNPK TP53BP2

1.48e-0446453int:RASD1
InteractionVAV1 interactions

PLCG2 MAP2K1 ZAP70 SH3BP2 HNRNPK

1.50e-04228455int:VAV1
InteractionPAX6 interactions

MAFB LDB1 BCL9 NIPBL PRRC2B BANP

1.54e-04366456int:PAX6
InteractionSCN5A interactions

CACNA1A CACNA1B BANP

1.57e-0447453int:SCN5A
InteractionSH3BP2 interactions

PLCG2 ZAP70 SH3BP2

1.68e-0448453int:SH3BP2
InteractionBCL9L interactions

LDB1 BCL9 PYGO1

1.68e-0448453int:BCL9L
InteractionORC6 interactions

LDB1 BCL9 PYGO1

1.78e-0449453int:ORC6
InteractionPAX9 interactions

LDB1 ATN1 BCL9 NIPBL

2.01e-04130454int:PAX9
InteractionEYA4 interactions

LDB1 ATN1 BCL9 MAP2K1 PRRC2B

2.02e-04243455int:EYA4
InteractionNAA40 interactions

USP8 IRS4 AFTPH PCBP1 NIPBL PICALM HNRNPK PRRC2B TP53BP2

2.63e-04978459int:NAA40
InteractionCDH1 interactions

USP8 MAP2K1 PCBP1 MYO7A PICALM HNRNPK TP53BP2 DDR2

2.65e-04768458int:CDH1
InteractionRPL35A interactions

MAFB PPP2R5D PTPN21 MAP2K1 PCBP1 HNRNPK

2.66e-04405456int:RPL35A
InteractionMAGEL2 interactions

USP8 IRS4 HNRNPK

3.42e-0461453int:MAGEL2
InteractionRNF43 interactions

IRS4 PCBP1 PICALM HNRNPK PRRC2B TP53BP2

3.53e-04427456int:RNF43
InteractionGRB2 interactions

USP8 IRS4 PLCG2 ZAP70 SH3BP2 HNRNPK TP53BP2 DDR2

3.66e-04806458int:GRB2
InteractionIFNAR1 interactions

ZAP70 HNRNPK STAT6

3.94e-0464453int:IFNAR1
InteractionNALCN interactions

CACNA1A CACNA1B

4.36e-0414452int:NALCN
InteractionIDI2 interactions

LDB1 LMX1B

4.36e-0414452int:IDI2
InteractionKLF15 interactions

IRS4 BCL9 NIPBL PRRC2B BANP

4.55e-04290455int:KLF15
InteractionMET interactions

CACNB1 PLCG2 PCBP1 ZAP70 SH3BP2

4.55e-04290455int:MET
InteractionSGF29 interactions

KLF3 ATN1 TP53BP2 BANP

4.86e-04164454int:SGF29
InteractionSCN11A interactions

CACNA1A CACNA1B

5.03e-0415452int:SCN11A
InteractionMEGF6 interactions

CACNA1A ATN1

5.74e-0416452int:MEGF6
InteractionDHX9 interactions

PLCB1 MAFB PCBP1 NIPBL HNRNPK DDR2 STAT6

6.12e-04662457int:DHX9
InteractionCIC interactions

KLF3 IRS4 LDB1 PCBP1 LMX1B HNRNPK BANP

6.75e-04673457int:CIC
InteractionPARD6A interactions

PLCB1 PTPN21 TP53BP2

7.04e-0478453int:PARD6A
InteractionSLC19A3 interactions

SLC19A3 CREB3L4

7.29e-0418452int:SLC19A3
GeneFamilyCalcium voltage-gated channel subunits

CACNA1A CACNA1B CACNB1

1.40e-0526333253
GeneFamilySH2 domain containing

PLCG2 ZAP70 SH3BP2 STAT6

3.31e-05101334741
GeneFamilyPhospholipases|C2 domain containing phospholipases

PLCB1 PLCG2

5.42e-0419332832
GeneFamilyPhospholipases

PLCB1 PLCG2

2.66e-0342332467
GeneFamilyBasic leucine zipper proteins

MAFB CREB3L4

3.60e-0349332506
GeneFamilyAnkyrin repeat domain containing|FERM domain containing

PTPN21 MYO7A

3.75e-03503321293
ToppCellCOVID-19_Mild|World / Disease condition and Cell class

MAFB SIGLEC1 PLCG2 GBP4 SH3BP2

1.66e-0619845561ceb2245b6cb58e308b999a61d218c89dbc615e
ToppCellInfluenza_Severe-gd_T|World / Disease group and Cell class

SLC19A3 ZNF683 ZAP70 DDR2

2.10e-05161454b3cdaed4d58d57e3c5dbc904a09388f3bf949407
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

PLCB1 ZNF683 MAFB PPP2R5D

2.72e-05172454a9e13aa36087170dadca421ba9de588e5a1cf715
ToppCell3'-Child09-12-SmallIntestine-Hematopoietic-T_cells-Th1|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNB1 MAP2K1 MYO7A ZAP70

2.72e-05172454c0c9a3f5b5fb942b049bc159fd9f21b5b706edd2
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-K_cells_(GIP+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1A PLCG2 DNAH12 LMX1B

2.84e-051744543503c7dec498597f76a86dbd5e4bb2311e743bde
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

ANKRD11 PLCB1 NIPBL TP53BP2

3.85e-05188454ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A1 PLCB1 GABRG3 DDR2

3.93e-05189454c734e5693808a0333139e87bd5be2597a9252afe
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A1 PLCB1 GABRG3 DDR2

4.01e-051904542e592323085ba9c019d678ac2a784462ab470ed9
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A1 PLCB1 GABRG3 DDR2

4.01e-05190454445952b70abffadb6ccc1ed4bbf61a88b06b73b3
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A1 PLCB1 GABRG3 DDR2

4.09e-05191454c54c420a94dc749ebc67fc64c5614663f4b9798d
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A1 PLCB1 GABRG3 DDR2

4.09e-05191454806b94f567ea09a9f443cd4091e70cdb1253ac08
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A1 PLCB1 GABRG3 DDR2

4.09e-05191454cb0aee740b08f7d5fdd2717ecf7429043b277ae7
ToppCellmoderate-Myeloid-Monocyte-derived_Macrophage|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

CACNA1A MAFB SIGLEC1 GBP4

4.26e-0519345422455801194bd8c73c5c397f5eac4f723429c383
ToppCellChildren_(3_yrs)-Immune-monocyte-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

PLCB1 MAFB MAP2K1 SH3BP2

4.44e-0519545481a28289eda1a8a1a31b7357106f64ac5000e172
ToppCellmoderate-Myeloid-Monocyte-derived_Macrophage|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

CACNA1A MAFB SIGLEC1 GBP4

4.44e-051954549c9634906168239cf978adb398787692437bf9e7
ToppCellCOVID-19_Mild-Classical_Monocyte-cMono_4|COVID-19_Mild / Disease condition and Cell class

MAFB SIGLEC1 PCBP1 SH3BP2

4.53e-051964543729d1444c65cad640377894decc64129bc3fd5b
ToppCellCOVID-19-lung-Macrophage_metabolically_active|lung / Disease (COVID-19 only), tissue and cell type

MAFB SIGLEC1 ABR MYO7A

4.53e-05196454a753d76d764c181eecb0e17a794a2e7d0ff70136
ToppCellCOVID-19_Mild|World / Disease group, lineage and cell class

ANKRD11 KLF3 SIGLEC1 PLCG2

4.62e-051974545c33454b10023decd2f5ccda9229b6512659711e
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PLCB1 CACNA1A CACNA1B GABRG3

4.71e-05198454c01091ef18e096d792ea2a7a715764a5b215355f
ToppCellprimary_auditory_cortex_(A1C)-Neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PLCB1 CACNA1A CACNA1B GABRG3

4.71e-051984546d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCellPBMC-Mild|PBMC / Location, Disease Group, Cell group, Cell class (2021.03.09)

ANKRD11 KLF3 SIGLEC1 PLCG2

4.71e-0519845444417089b62056269cac38d3134ff209c05b7007
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PLCB1 CACNA1A CACNA1B GABRG3

4.71e-051984544ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCellPBMC-Mild|PBMC / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ANKRD11 KLF3 SIGLEC1 PLCG2

4.71e-0519845428ef3fc4c17dcb765537b75917f7db78baa522db
ToppCellmild-HLA-DR+_CD83+_Monocyte|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

MAFB SIGLEC1 PLCG2 SH3BP2

4.89e-05200454934c2efc780318c66d667ca75be0de350361d351
ToppCellCOVID-19|World / group, cell type (main and fine annotations)

MAFB PLCG2 PCBP1 PICALM

4.89e-05200454ac38a468559c33ee00152735ce6e408f3f48df84
ToppCellNeuronal|World / cells hierarchy compared to all cells using T-Statistic

PLCB1 CACNA1A CACNA1B GABRG3

4.89e-0520045448d801219bc771d6c7e151dc88ca4c179988de85
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ANKRD11 SIGLEC1 PLCG2 NIPBL

4.89e-0520045412f1685ce8f218433068e090c9d839cd5a1910bf
ToppCellBronchial-NucSeq-Immune_Myeloid-Macrophage_other|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MAFB SIGLEC1 ABR MYO7A

4.89e-0520045478d75d381cb2b9a4c9eb7c32a07b014eaee39195
ToppCellCOVID-19|World / Disease, condition lineage and cell class

ANKRD11 KLF3 PLCG2 NIPBL

4.89e-052004547dec470c379cd89f05a0f37c8628b21f136e52f0
ToppCellControl_saline-Mesenchymal_myocytic-Pericyte-Pericyte_2|Control_saline / Treatment groups by lineage, cell group, cell type

COL4A1 PLCB1 ABR DDR2

4.89e-05200454bc8949eb34482aca166c4602ff6ab876cb4c2c3c
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Lhx6|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

GABRG3 MAFB DDR2

2.25e-041174530602bbad908cb28c5093b74d717da5f2af577943
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Tac2_Tacstd2|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

MAFB IRS4 PLCG2

2.36e-04119453e868453c02dcf0e07821886b81ca739887d43c67
ToppCellControl-Neu_0|World / 5 Neutrophil clusters in COVID-19 patients

CACNB1 LMX1B PYGO1

2.42e-04120453840d0ac995e2fa41996514753e4e03c4aa4a26d0
ToppCellFrontal_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_2|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

SLC19A3 GBP4 CREB3L4

3.13e-04131453d5bc40cd585582856881081b7130dec3515b4ae0
ToppCellNS-moderate-d_16-33-Epithelial-unknown_epithelial|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

MUC16 MAFB IRS4

3.57e-0413745303e124901a0e85b59b6882bbafab568b50907e8b
ToppCellTracheal-10x5prime-Immune_Lymphocytic-T-T_CD8-gdT|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ZNF683 MYO7A ZAP70

3.65e-04138453769be787e24532d5e023f99f82c7272bddac40c3
ToppCellEndothelial-F|World / shred on cell class and cell subclass (v4)

COL4A1 PLCB1 GBP4

3.72e-0413945332d3c5d35e6c4205711c3500d736fd108443e6b4
ToppCellCOVID-19-kidney-Technical/muscle_(Mes)|COVID-19 / Disease (COVID-19 only), tissue and cell type

CACNA1A CACNA1B GABRG3

4.47e-04148453d6ac5972267254651dfbe16bb4e9a62228093cc7
ToppCellCOVID-19-kidney-Technical/muscle_(Imm)|COVID-19 / Disease (COVID-19 only), tissue and cell type

CACNA1A CACNA1B GABRG3

4.65e-041504530205318a870e091add66ee4305747dda9f51510d
ToppCell367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

SLC19A3 KLF3 ZNF683

5.02e-04154453ea5d0da5dd8ccfc19969aec35f044db77d589f54
ToppCellCOVID-19_Moderate-multiplets|World / disease group, cell group and cell class

ZNF683 PLCG2 ZAP70

5.21e-04156453afdc025fa75e7926b1cc182c4a33654a2186abb1
ToppCellmetastatic_Brain-T/NK_cells-Naive_CD8+_T|metastatic_Brain / Location, Cell class and cell subclass

ZNF683 PLCG2 ZAP70

5.21e-041564531dcb0b2d1c4b524e692d40e8403dbf7140af19b4
ToppCellCOVID-19-kidney-Technical/muscle_(Mes)|kidney / Disease (COVID-19 only), tissue and cell type

CACNA1A CACNA1B GABRG3

5.51e-041594535335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

ZNF683 PPP2R5D ZAP70

5.61e-041604538e2b51d7b42e0b6e62641efdbbc73d31561d6a3e
ToppCellLPS-IL1RA-Stromal_mesenchymal-Fibroblasts-MatrixFB_->_Myofibroblast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNB1 GATA5 STAT6

5.61e-04160453778faada072e3abfa76a9a06fd4885fb63de7902
ToppCellE18.5-samps-Myeloid-Macrophage-macrophage_-_intermediate_-_unactivated|E18.5-samps / Age Group, Lineage, Cell class and subclass

PLCG2 MYO7A SH3BP2

5.82e-0416245360d3fe1f5cec4285b8774ff078ebcc6bfaec26ed
ToppCellE18.5-samps-Myeloid|E18.5-samps / Age Group, Lineage, Cell class and subclass

PLCG2 MYO7A SH3BP2

5.82e-0416245318e4a807e25f754a69e9eaaddfde40f8de9b8512
ToppCellE18.5-samps-Myeloid-Macrophage|E18.5-samps / Age Group, Lineage, Cell class and subclass

PLCG2 MYO7A SH3BP2

5.82e-041624530970e4eda60e3f015335e2726e6d565fb2f43372
ToppCelldroplet-Marrow-BM-30m-Lymphocytic-plasma_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAFB SIGLEC1 PYGO1

6.03e-04164453758e85e2f5e7236b345e16c78344d5e0bf17d8dc
ToppCell3'-Child09-12-SmallIntestine-Hematopoietic-T_cells-ILC3|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PLCB1 CACNB1 MYO7A

6.03e-04164453631ec9f54475dcc9d6b1c5bf6917e7fda4671034
ToppCellChildren_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

CACNA1A CACNA1B LMX1B

6.03e-04164453be49af6335f2505065cde2cb9800e4a5516811b1
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Reln_Tac1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

KLF3 MAFB DCBLD2

6.14e-04165453d8df50f5a3b646e8ea13739fdc65ce6f39b4d4d2
ToppCellfacs-Marrow-T_cells-18m-Lymphocytic-late_pro_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNB1 ATN1 LMX1B

6.14e-041654530edd56e8d14eaeced9882dd9206ea93e8f402e8d
ToppCellCerebellum-Endothelial-ENDOTHELIAL_STALK|Cerebellum / BrainAtlas - Mouse McCarroll V32

SLC19A3 GBP4 ZAP70

6.14e-041654537d319a112b9062efee428bef6f4534d2ce782e04
ToppCellfacs-Marrow-T_cells-18m-Lymphocytic-late_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNB1 ATN1 LMX1B

6.14e-04165453fa3aadfff6fb1e7f142db333c60c2cba02b17e6c
ToppCellAdult-Immune-interstitial_macrophage_(C1Q_positive)-D122|Adult / Lineage, Cell type, age group and donor

MAFB SIGLEC1 MYO7A

6.25e-04166453be284e2e596390f05305c7bcfc316f87b963fc0b
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6|356C / Donor, Lineage, Cell class and subclass (all cells)

PLCB1 ZNF683 PPP2R5D

6.25e-04166453c4f7ea1cad962b1d6ad77423d15978b68a0d6f1d
ToppCellControl-Epithelial-Mesothelial|Control / Disease state, Lineage and Cell class

MUC16 GATA5 DDR2

6.25e-041664531ed3788257e14f097862b999f020bfe2a57de52b
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CACNA1A CACNA1B GABRG3

6.36e-041674533edb0570e583bb527165bcd8a4c25a042054043b
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Hematologic-fibroblast|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A SIGLEC1 SH3BP2

6.36e-04167453f5bffa77061baec0ba87bd688a047595f32534db
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MAFB GATA5 LMX1B

6.47e-04168453fc80e4fecfc92458eb627013a983041d8ca025a9
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_ILC-NK_cell|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

ZNF683 PLCG2 MYO7A

6.47e-04168453b4bb03efb601a61465260f93896c56861c588bef
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MAFB GATA5 LMX1B

6.47e-04168453315ca578c945aeeb77acda2727f3e6db8b43f43e
ToppCelldroplet-Spleen-SPLEEN-1m-Hematologic-proerythroblast|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLCB1 LRP5 MAFB

6.47e-04168453f3b7a7df54988de77dcc7066e2fc1feb9c280b13
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_ILC|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

ZNF683 PLCG2 MYO7A

6.47e-04168453240ea32b64d86f9216785010d6b237d9adf052c9
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MAFB GATA5 LMX1B

6.47e-04168453e96859dbf51cf8c4def8ee8db132f4d874fb4381
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c01-FCGR3A|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

ZNF683 PLCG2 MYO7A

6.58e-04169453e7470a5b060881b2a8ce2ab04b0788396aa13889
ToppCelldroplet-Spleen-SPLEEN-1m-Hematologic|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLCB1 LRP5 MAFB

6.69e-041704537cb7ad9ab064b6ea452545d145e5b1d4090cd4c1
ToppCellControl-Classical_Monocyte-cMono_4|Classical_Monocyte / Disease condition and Cell class

KLF3 MAFB SIGLEC1

6.69e-041704539e328e1f904c77dcce8aee4df775d7f0ac725775
ToppCelldroplet-Spleen-SPLEEN-1m-Hematologic-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLCB1 LRP5 MAFB

6.69e-04170453db7cee7e518debb2cbe9eeae05d47e14b69cb8e3
ToppCelldroplet-Thymus-nan-21m-Lymphocytic-Macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNB1 MAFB MYO7A

6.81e-04171453a474aaed3ca4cacb0ab565c35f25d92a10f531b7
ToppCellControl-Fibroblasts-Pericytes|Control / group, cell type (main and fine annotations)

COL4A1 PLCB1 DDR2

6.81e-04171453080003f698f867935c2bfc55d241d3650f45a0ab
ToppCell390C-Myeloid-Macrophage-SPP1+_Macrophage_4|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

CACNB1 SIGLEC1 CREB3L4

6.81e-041714537c8304573b892ef9ea4e048cba9ea9fbab848dcd
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SLC19A3 SIGLEC1 ABR

6.92e-04172453c8ea80042faf923b08ff03d73100533d521d73ef
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c08-IL2RB|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

ZNF683 PLCG2 MYO7A

6.92e-04172453e3a8891694343b6b01e80a200ae338d24797e417
ToppCellAdult-Mesenchymal-pericyte_cell-D175|Adult / Lineage, Cell type, age group and donor

COL4A1 PLCB1 DDR2

7.04e-04173453fd6653d6be9ca6ac36798590694efe03cb758c67
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL4A1 DDR2 PYGO1

7.16e-04174453f90ca117b729436cf452e2ddcec26ba525c5c13b
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

ZNF683 MAFB PPP2R5D

7.28e-04175453f3a68aeb79c4935006e17a5ff3445a8ec0e33f5f
ToppCellMonocytes-IFN-activated_Monocytes|Monocytes / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

CACNA1A ZNF683 GBP4

7.40e-041764536a4b403ee3e4dc4f23fbd7a154011e41fd429a9e
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL4A1 PLCB1 GBP4

7.40e-04176453269326c2bf44a9003d95bc6dbc839f08f25737ca
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1A DNAH12 LMX1B

7.40e-0417645371f96cace3f20fbef975037f4deff9b82b0282a1
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

GATA5 ABR GBP4

7.40e-04176453dc5a22f9d1347f157bdd93e6e5769b983deccf1a
ToppCellPND14-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SIGLEC1 MYO7A SH3BP2

7.40e-04176453b0b87eebcf5c994386b39ca607e17f10e9d9de74
ToppCellControl-Myeloid-MoAM2,_CCL18|Myeloid / Condition, Lineage and Cell class

PLCB1 MAFB MYO7A

7.52e-04177453470f54fe2b21c7350ea471e02039461a3808f700
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-regulatory_T_cell-regulatory_T_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SLC19A3 GBP4 ZAP70

7.52e-04177453fd4a297e519b3959811a462d63feebff76429031
ToppCelldroplet-Lung-nan-21m-Lymphocytic-regulatory_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC19A3 GBP4 ZAP70

7.52e-041774538cc74873f4d2d0f81042426a687b01750abc72d2
ToppCellPND01-Immune-Immune_Myeloid-Monocytic-Macrophage|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MAFB MYO7A SH3BP2

7.52e-041774531e7b4c0e41649d57a2c219a3b7e693538b8b34e4
ToppCelldroplet-Lung-nan-21m-Lymphocytic-Regulatory_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC19A3 GBP4 ZAP70

7.52e-04177453fe0f6a73264632bdd4f9fbc22de2d155ba2bcf8c
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-regulatory_T_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SLC19A3 GBP4 ZAP70

7.52e-04177453e995230ef207dcd87eab4550617589016ffa9970
ToppCell15-Airway-Immune-Hematopoietic,_Natural_Killer_Cell|Airway / Age, Tissue, Lineage and Cell class

ZNF683 PLCG2 ZAP70

7.65e-041784530003c3f2561b7a1fd86772bcba59883ba1f17cd2
ToppCelldroplet-Limb_Muscle-MUSCLE-30m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANKRD11 KLF3 GBP4

7.65e-0417845301dafd19de04eff459253eaa9a35debf8f3deedf
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c07-TYROBP|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ZNF683 CACNB1 ZAP70

7.90e-04180453557453b74d4a9cc95ed1c7b9a9a58e45eb02ed6a
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A1 GABRG3 DDR2

7.90e-04180453280ff5c8f292be1b88120db5ff1788b750644856
ToppCellAdult-Immune-natural_killer_cell-D175|Adult / Lineage, Cell type, age group and donor

PLCB1 ZNF683 ZAP70

7.90e-04180453fc59e28f39e7d4fb1bcc7205202cf39224b70d7b
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A1 GABRG3 DDR2

7.90e-04180453fdbd7c22044d9328a1e06e2f9a4451529d1df767
ToppCellfacs-Liver-Liver_non-hepato/SCs-18m-Lymphocytic-T_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNB1 IRS4 ZAP70

7.90e-041804538cef63866c205df3825df84ce51fa61aa04ae491
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-I_cells_(INS+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MAFB DNAH12 LMX1B

7.90e-041804530c5d9245b8a7cc34ad52522d31559906cda55bdf
ToppCellChildren_(3_yrs)-Mesenchymal-pericyte_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

COL4A1 PLCB1 DDR2

8.02e-04181453451b87ac95154bb80018b8dd245b4a6389d81411
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c11-GNLY|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CACNB1 PPP2R5D ZAP70

8.02e-041814535cecbafc29cc95896e6ccb2c74d9237b9aaece69
ToppCellControl-Classical_Monocyte-cMono_4|Control / Disease condition and Cell class

MAFB SIGLEC1 SH3BP2

8.02e-04181453f3e1d8fe5cf1eba19e51c3680a55306cae687fe9
DrugEthylnitrosourea

COL4A1 ANKRD11 CACNA1A LRP5 PLCG2 MYO7A DCBLD2 ZAP70

9.25e-08291458ctd:D005038
Druggenistein

PLCB1 CACNA1A CACNA1B GABRG3 CACNB1 PLCG2 ATN1 MAP2K1 PCBP1 ZAP70 HNRNPK DDR2

1.17e-0611174512CID005280961
DrugIsoetharine mesylate salt [7279-75-6]; Down 200; 12uM; MCF7; HT_HG-U133A

EML2 MAFB PTPN21 LDB1 BCL9 PRRC2B

2.54e-061994567170_DN
DrugAC1L1KS5

PLCB1 CACNA1A CACNA1B CACNB1 PLCG2 ATN1 MAP2K1

3.86e-06334457CID000005631
DrugVerapamil

CACNA1A CACNA1B CACNB1

3.97e-0616453DB00661
DrugBiliverdin hydrochloride

CACNA1B MAFB SIGLEC1 ATN1 TP53BP2

1.43e-05157455CID000000251
DrugAC 110

CACNA1A CACNA1B

2.29e-054452CID000022860
Drugpapaverine

PLCB1 CACNA1A CACNA1B CACNB1 PLCG2

2.48e-05176455CID000004680
DrugAC1Q6T8I

PLCB1 SIGLEC1 PLCG2

2.82e-0530453CID000000343
Drughalothane

PLCB1 CACNA1A CACNA1B GABRG3 CACNB1 PLCG2

3.40e-05314456CID000003562
Drug3-aminopropylphosphinic acid

CACNA1A CACNA1B GABRG3

3.44e-0532453CID006335948
DrugSulconazole nitrate [61318-91-0]; Up 200; 8.6uM; MCF7; HT_HG-U133A

COL4A1 PLCB1 CACNB1 PTPN21 ATN1

3.49e-051894554998_UP
DrugCNS 1145

CACNA1A CACNA1B CACNB1

3.78e-0533453CID000190902
DrugIHC-64

CACNA1A CACNA1B CACNB1

3.78e-0533453CID000162753
DrugS 8510

CACNA1A CACNA1B

3.81e-055452CID005488383
DrugMuramic acid, N-acetyl [10597-89-4]; Up 200; 13.6uM; MCF7; HT_HG-U133A

CACNA1A PTPN21 ATN1 SH3BP2 PRRC2B

3.86e-051934553262_UP
DrugAmoxapine [14028-44-5]; Up 200; 12.8uM; MCF7; HT_HG-U133A

PLCB1 KLF3 EML2 PTPN21 SH3BP2

3.86e-051934554996_UP
DrugBephenium hydroxynaphthoate [3818-50-6]; Down 200; 9uM; MCF7; HT_HG-U133A

PLCB1 KLF3 PTPN21 LDB1 STAT6

3.95e-051944555263_DN
Drugbutein; Down 200; 10uM; PC3; HG-U133A

COL4A1 PLCB1 CACNB1 ABR PRRC2B

3.95e-05194455582_DN
DrugAmyleine hydrochloride [532-59-2]; Down 200; 14.8uM; MCF7; HT_HG-U133A

CACNA1A KLF3 EML2 DCBLD2 SH3BP2

3.95e-051944554169_DN
DrugFluocinonide [356-12-7]; Up 200; 8uM; PC3; HT_HG-U133A

KLF3 CACNB1 PTPN21 ATN1 ZAP70

4.05e-051954553757_UP
DrugSulfamethazine sodium salt [1981-58-4]; Down 200; 13.4uM; MCF7; HT_HG-U133A

PLCG2 LDB1 BCL9 SH3BP2 STAT6

4.15e-051964553422_DN
Drugretinoic acid; Up 200; 1uM; MCF7; HG-U133A

LRP5 CACNB1 ABR SH3BP2 PRRC2B

4.15e-05196455384_UP
DrugIodipamide [606-17-7]; Up 200; 3.6uM; MCF7; HT_HG-U133A

PLCB1 CACNA1A CACNB1 DCBLD2 STAT6

4.15e-051964555510_UP
DrugFamotidine [76824-35-6]; Up 200; 11.8uM; MCF7; HT_HG-U133A

PLCB1 CACNB1 PTPN21 ATN1 LMX1B

4.15e-051964555011_UP
DrugCP-320650-01 [172079-28-6]; Down 200; 1uM; PC3; HT_HG-U133A

KLF3 EML2 PTPN21 ATN1 MYO7A

4.15e-051964554560_DN
DrugPHA-00767505E [723337-45-9]; Down 200; 10uM; PC3; HT_HG-U133A

KLF3 EML2 PTPN21 LDB1 BANP

4.15e-051964556591_DN
DrugMafenide hydrochloride [138-37-4]; Down 200; 18uM; MCF7; HT_HG-U133A

MAFB PTPN21 ATN1 BCL9 PICALM

4.15e-051964555499_DN
DrugPregnenolone [145-13-1]; Down 200; 12.6uM; MCF7; HT_HG-U133A

KLF3 PTPN21 ATN1 BCL9 SH3BP2

4.15e-051964554802_DN
DrugCetirizine dihydrochloride [83881-52-1]; Down 200; 8.6uM; MCF7; HT_HG-U133A

PPP2R5D LDB1 PICALM SH3BP2 PRRC2B

4.15e-051964554815_DN
Drug(+) -Levobunolol hydrochloride [47141-41-3]; Down 200; 12.2uM; MCF7; HT_HG-U133A

KLF3 MAFB PTPN21 DCBLD2 SH3BP2

4.25e-051974553355_DN
DrugRaloxifene hydrochloride [82640-04-8]; Up 200; 7.8uM; PC3; HT_HG-U133A

PLCB1 CACNB1 MYO7A SH3BP2 STAT6

4.25e-051974555759_UP
DrugCotinine (-) [486-56-6]; Up 200; 22.6uM; MCF7; HT_HG-U133A

CACNB1 ATN1 ZAP70 SH3BP2 STAT6

4.25e-051974555246_UP
DrugPraziquantel [55268-74-1]; Up 200; 12.8uM; MCF7; HT_HG-U133A

SLC19A3 PLCB1 IRS4 MYO7A SH3BP2

4.25e-051974553189_UP
Drug(+)-Isoproterenol (+)-bitartrate salt [14638-70-1]; Up 200; 11uM; MCF7; HT_HG-U133A

PLCB1 CACNB1 PTPN21 LMX1B STAT6

4.25e-051974555009_UP
DrugTheophylline monohydrate [5967-84-0]; Down 200; 20.2uM; MCF7; HT_HG-U133A

PLCB1 EML2 ATN1 SH3BP2 STAT6

4.36e-051984553326_DN
DrugNafcillin sodium salt monohydrate [7177-50-6]; Up 200; 8.8uM; MCF7; HT_HG-U133A

COL4A1 PTPN21 ATN1 LMX1B SH3BP2

4.36e-051984553323_UP
DrugPhenethicillin potassium salt [132-93-4]; Up 200; 10uM; MCF7; HT_HG-U133A

KLF3 CACNB1 PTPN21 ATN1 SH3BP2

4.36e-051984556239_UP
DrugDiflorasone Diacetate [33564-31-7]; Up 200; 8uM; MCF7; HT_HG-U133A

GABRG3 EML2 CACNB1 MAFB IRS4

4.36e-051984554158_UP
DrugMetformin hydrochloride [1115-70-4]; Down 200; 24.2uM; MCF7; HT_HG-U133A

PLCG2 PTPN21 ABR ATN1 PRRC2B

4.36e-051984555487_DN
DrugGlycopyrrolate [596-51-0]; Up 200; 10uM; PC3; HT_HG-U133A

CACNA1A KLF3 PTPN21 ABR SH3BP2

4.36e-051984557386_UP
DrugAlprostadil [745-65-3]; Up 200; 11.2uM; MCF7; HT_HG-U133A

COL4A1 CACNA1A GABRG3 CACNB1 MYO7A

4.36e-051984554179_UP
DrugDimethadione [695-53-4]; Up 200; 31uM; MCF7; HT_HG-U133A

COL4A1 MAFB IRS4 DCBLD2 SH3BP2

4.36e-051984553367_UP
DrugMefenamic acid [61-68-7]; Up 200; 16.6uM; MCF7; HT_HG-U133A

KLF3 IRS4 PTPN21 ATN1 SH3BP2

4.46e-051994555534_UP
DrugAmidopyrine [58-15-1]; Up 200; 17.2uM; MCF7; HT_HG-U133A

CACNA1A LDB1 ATN1 DCBLD2 SH3BP2

4.46e-051994556818_UP
Drug0317956-0000 [391210-11-0]; Up 200; 10uM; PC3; HT_HG-U133A

PLCB1 CACNB1 ATN1 SH3BP2 STAT6

4.46e-051994553774_UP
DrugProtoveratrine A [143-57-7]; Down 200; 5uM; HL60; HT_HG-U133A

PLCB1 CACNA1A CACNB1 PLCG2 SH3BP2

4.46e-051994552144_DN
DrugEucatropine hydrochloride [536-93-6]; Up 200; 12.2uM; MCF7; HT_HG-U133A

EML2 CACNB1 IRS4 SH3BP2 STAT6

4.57e-052004553935_UP
DrugCosopt

KLF3 MAFB GATA5 ABR LDB1 MAP2K1

5.38e-05341456CID000003154
Drugsevoflurane

PLCB1 GABRG3 LRP5 PLCG2

5.50e-05105454CID000005206
DrugSKF83742

PLCB1 PLCG2

5.70e-056452CID000130828
Drug3,4-dihydroquinazoline

CACNA1A CACNA1B

5.70e-056452CID000583065
Drugalpha-sialylcholesterol

CACNA1A CACNA1B

5.70e-056452CID000133976
DrugAPMPA

CACNA1A CACNA1B

7.97e-057452CID000512300
DrugAC1NBU2S

CACNA1A CACNA1B CACNB1 MAP2K1

8.39e-05117454CID004473765
Drugh PM

CACNA1A CACNA1B ABR

9.66e-0545453CID005494424
Drugtyrphostin 25

PLCG2 MAP2K1 ZAP70 STAT6

9.86e-05122454CID000002061
DrugAC1L1DKK

PLCG2 MAP2K1 ZAP70 STAT6

1.15e-04127454CID000002390
Drugheptachlor

PLCB1 GABRG3 PLCG2 MAP2K1

1.22e-04129454CID000003589
Drug3-nitrocoumarin

PLCB1 PLCG2

1.70e-0410452CID002799766
DrugCinildipine

CACNA1A CACNA1B CACNB1

1.86e-0456453CID000002752
Drugnimodipine

CACNA1A CACNA1B GABRG3 CACNB1

1.92e-04145454CID000004497
DrugPI(3,4,5)P3

CACNB1 PLCG2 MAP2K1 ZAP70

2.08e-04148454CID000643963
Drug4-aminopiperidine

CACNA1A CACNA1B

2.08e-0411452CID000424361
Drugleys

CACNA1A CACNA1B

2.08e-0411452CID000484683
Drugidebenone

CACNA1A ATN1 MAP2K1

2.17e-0459453CID000003686
Druglead compounds

PLCB1 CACNA1A PLCG2 HNRNPK

2.19e-04150454CID000073212
Drugnilvadipine

CACNA1A CACNA1B CACNB1

2.28e-0460453CID000004494
Drugprocaine

CACNA1A CACNA1B GABRG3 CACNB1

2.36e-04153454CID000004914
DrugIAA-94

CACNA1A CACNA1B CACNB1

2.40e-0461453CID000003667
DrugAC1NSKHI

PLCB1 PLCG2 ATN1

2.40e-0461453CID005311358
DrugU46619

PLCB1 CACNA1A CACNA1B CACNB1 PLCG2

2.41e-04285455CID000005618
Druglindane

PLCB1 CACNA1B GABRG3 PLCG2

2.42e-04154454CID000000727
DrugAC1L2VU3

CACNA1A CACNA1B

2.49e-0412452CID000129572
Drug(4S,4aR,5aS,6S,12aR)-7-chloro-4-(dimethylamino)-6,10,11,12-tetrahydroxy-1,3-dioxo-4a,5,5a,6,11,11a,12,12a-octahydro-4H-tetracene-2-carboxamide

PLCB1 PLCG2

2.49e-0412452CID011840935
DrugAC1L1II7

PLCB1 PLCG2

2.49e-0412452CID000004589
Druglercanidipine

CACNA1A CACNA1B CACNB1

2.64e-0463453CID000065866
DrugD 609

PLCB1 PLCG2 MAP2K1

2.76e-0464453CID000002940
Drugmibefradil

CACNA1A CACNA1B CACNB1

2.76e-0464453CID000060662
Drugphenylpropane

SIGLEC1 ATN1

2.94e-0413452CID000007668
Druggallopamil

CACNA1A CACNA1B CACNB1

3.16e-0467453CID000001234
Drugvanadyl

SIGLEC1 PLCG2 MAP2K1 MYO7A STAT6

3.39e-04307455CID000061671
DrugAC1L1JG6

CACNA1A CACNA1B

3.42e-0414452CID000005026
Druggabapentin

CACNA1A CACNA1B GABRG3 CACNB1

3.44e-04169454CID000003446
DrugAC1L2AC7

CACNA1A CACNA1B CACNB1

3.45e-0469453CID000068733
Druglavendustin A

CACNA1A CACNA1B CACNB1 MAP2K1

3.60e-04171454CID000003894
Drugvorinostat

CACNA1A CACNA1B ATN1 MAP2K1 STAT6

3.76e-04314455CID000005311
Drugriluzole

CACNA1A CACNA1B GABRG3 CACNB1

3.84e-04174454CID000005070
DrugBarium

PLCB1 CACNA1A CACNA1B

3.91e-0472453ctd:D001464
Drugmonomethylarsonous acid

PLCB1 EML2 MAFB ATN1 MAP2K1 DCBLD2 STAT6

3.93e-04694457ctd:C406082
Drugbutamben

CACNA1A CACNA1B

3.95e-0415452CID000002482
DrugCAS 298-57-7

CACNA1A CACNA1B CACNB1

4.07e-0473453CID000002761
DrugCortisporin

PLCB1 CACNA1A CACNA1B PLCG2

4.10e-04177454CID000004454
Drugethosuximide

CACNA1A CACNA1B CACNB1

4.24e-0474453CID000003291
DrugBAPTA

PLCB1 CACNA1A CACNA1B GABRG3 MAP2K1

4.33e-04324455CID000104751
Drugpentasulfane

CACNA1A CACNA1B

4.50e-0416452CID000448216
DrugClemastine fumarate [14976-57-9]; Up 200; 8.6uM; MCF7; HT_HG-U133A

COL4A1 PLCB1 MAFB PTPN21

4.65e-041834547443_UP
DrugMephentermine hemisulfate [1212-72-2]; Up 200; 9.4uM; MCF7; HT_HG-U133A

COL4A1 GABRG3 ATN1 DCBLD2

4.85e-041854544707_UP
DrugChrysamine-G

CACNA1A CACNA1B ATN1

4.95e-0478453CID005488970
Drugnisoldipine

CACNA1A CACNA1B CACNB1

4.95e-0478453CID000004499
Diseasenail-patella syndrome (implicated_via_orthology)

LDB1 LMX1B

2.27e-062452DOID:9467 (implicated_via_orthology)
Diseasefamilial hemiplegic migraine 1 (implicated_via_orthology)

CACNA1A CACNA1B

6.82e-063452DOID:0111181 (implicated_via_orthology)
Diseasemigraine (implicated_via_orthology)

CACNA1A CACNA1B

1.36e-054452DOID:6364 (implicated_via_orthology)
Diseasehereditary ataxia (implicated_via_orthology)

CACNA1A CACNA1B

4.75e-057452DOID:0050951 (implicated_via_orthology)
DiseaseHematuria

COL4A1 LMX1B

8.13e-059452C0018965
DiseaseFEV/FEC ratio

COL4A1 ANKRD11 USP8 MAFB GATA5 DNAH12 ABR LMX1B SH3BP2

8.32e-051228459EFO_0004713
Diseasecyclic AMP-responsive element-binding protein 3-like protein 4 measurement

USP8 CREB3L4

1.02e-0410452EFO_0801506
Diseaseplatelet component distribution width

COL4A1 PLCB1 MAFB SIGLEC1 GATA5 PLCG2 HNRNPK

1.36e-04755457EFO_0007984
DiseaseImpaired cognition

COL4A1 PICALM

2.05e-0414452C0338656
DiseaseNeurodevelopmental Disorders

ANKRD11 PPP2R5D LMX1B

3.91e-0493453C1535926
Diseasemean platelet volume

COL4A1 ANKRD11 PLCB1 KLF3 PLCG2 MAP2K1 PICALM

8.32e-041020457EFO_0004584
Diseasesocial communication impairment

PLCB1 LMX1B

1.10e-0332452EFO_0005427
DiseaseGlobal developmental delay

COL4A1 CACNA1B ATN1

1.11e-03133453C0557874
Diseaseovarian neoplasm

MUC16 BCL9 MAP2K1

1.13e-03134453C0919267
DiseaseMalignant neoplasm of ovary

MUC16 BCL9 MAP2K1

1.20e-03137453C1140680
DiseaseAutoinflammatory disorder

PLCG2 SH3BP2

1.31e-0335452C3860213
DiseaseFocal glomerulosclerosis

COL4A1 LMX1B

1.39e-0336452C0017668

Protein segments in the cluster

PeptideGeneStartEntry
TMPYIDESPTMSPQL

ABR

46

Q12979
SSYCPSEPMMSTPPP

BANP

341

Q8N9N5
DRTPLMFQRMEPPSP

CACNA1A

1981

O00555
PAASSYDSPMPPSME

ANKRD11

1816

Q6UB99
YDSPMPPSMEDRAPL

ANKRD11

1821

Q6UB99
SMSRGPYPPSQEIPM

CACNB1

6

Q02641
MEPDIIRMYSSSPPP

AFTPH

1

Q6ULP2
PTGYHAPMEPPTSRM

ATN1

191

P54259
PATPRRMSDPPLSTM

SH3BP2

271

P78314
MFRAPPPLPPVYSME

PPP2R5D

521

Q14738
VMRSGPRPIVPYSSM

CACNA1B

1116

Q00975
AVGPYIQSSTMPRMP

TP53BP2

346

Q13625
YWLSTPEPMPMSMAP

COL4A1

1521

P02462
PLSSYGMDSRPPMAI

MAP2K1

296

Q02750
TEMMITTPYVFPDVP

MUC16

10521

Q8WXI7
GRVMTIPYQPMPASS

PCBP1

176

Q15365
YPEEMSPPLMNSVSP

KLF3

211

P57682
SMGPELPTSPLAMEY

MAFB

6

Q9Y5Q3
TMLDRDVGPTPMYPP

LDB1

36

Q86U70
ALPTSPMAPTTYDPM

DDR2

376

Q16832
PPSPATDPSLYNMDM

LRP5

1501

O75197
PYLIAMGTDPEPAMR

NIPBL

2321

Q6KC79
LPPPDYPQTMTSEMK

DNAH12

76

Q6ZR08
PTPGYPESESIMMAP

GBP4

11

Q96PP9
SRMYVDPSEINPSMP

PLCG2

756

P16885
SSRMSLPKPQPYVMP

PTPN21

326

Q16825
PMFVPPARVPSMLSY

GATA5

31

Q9BWX5
YSLLDMRPPPTAMIT

GABRG3

376

Q99928
RDVPFSPDEMVPPSM

BCL9

436

O00512
PMMIPDELAPTYSLD

EML2

31

O95834
PITGPEYATPIIMDM

DCBLD2

671

Q96PD2
SMMRPSEPFLIPYLS

SLC19A3

26

Q9BZV2
PPAPRATSSPMLYEV

CREB3L4

101

Q8TEY5
RGYMMMFPRVSPPPA

IRS4

741

O14654
YSTFRMPPHVPPRMS

PYGO1

101

Q9Y3Y4
RPMPPSRRDYDDMSP

HNRNPK

271

P61978
ATMAPPVMAYPATTP

PICALM

591

Q13492
SPDKPRPMPMDTSVY

ZAP70

301

P43403
LPTPELQMPTMVPSY

STAT6

656

P42226
MMPSYMDPRITPTRT

PRRC2B

676

Q5JSZ5
YPPKTPTMMVFVEPE

SIGLEC1

1531

Q9BZZ2
LESGVPLPSPMDLMY

PLCB1

446

Q9NQ66
SPTNTVHMYPPEMAP

USP8

671

P40818
MLPQDPSYPTMAMPS

ZNF683

221

Q8IZ20
RMEGMMASYTPLAPP

LMX1B

301

O60663
SVYVMPTVTMPPREI

MYO7A

1666

Q13402