Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionchloride ion binding

SLC22A6 WNK4

2.94e-0416322GO:0031404
GeneOntologyMolecularFunctionprotein kinase activity

EPHB4 IRAK1 PRKDC IGF2R MAPK7 WNK4

3.34e-04600326GO:0004672
GeneOntologyBiologicalProcessnegative regulation of protein phosphorylation

DAB2IP PRKDC SFRP5 DMD WNK4 HYAL2

2.54e-05375336GO:0001933
GeneOntologyBiologicalProcessnegative regulation of intracellular signal transduction

DAB2IP PDE3B PRKDC SFRP5 DMD MAPK7 SZT2 HYAL2

2.77e-05795338GO:1902532
GeneOntologyBiologicalProcessnegative regulation of phosphorylation

DAB2IP PRKDC SFRP5 DMD WNK4 HYAL2

3.69e-05401336GO:0042326
GeneOntologyBiologicalProcessnegative regulation of non-canonical Wnt signaling pathway

RNF213 SFRP5

8.87e-059332GO:2000051
GeneOntologyBiologicalProcessrenal system process

SLC22A6 SUCNR1 WNK4 HYAL2

9.09e-05149334GO:0003014
GeneOntologyBiologicalProcessnegative regulation of MAP kinase activity

DAB2IP SFRP5 HYAL2

9.25e-0555333GO:0043407
GeneOntologyBiologicalProcessnegative regulation of phosphate metabolic process

DAB2IP PRKDC SFRP5 DMD WNK4 HYAL2

9.77e-05478336GO:0045936
GeneOntologyBiologicalProcessnegative regulation of phosphorus metabolic process

DAB2IP PRKDC SFRP5 DMD WNK4 HYAL2

1.00e-04480336GO:0010563
GeneOntologyBiologicalProcessnegative regulation of protein modification process

DAB2IP PRKDC SFRP5 DMD WNK4 HYAL2

1.42e-04512336GO:0031400
GeneOntologyBiologicalProcessregulation of JUN kinase activity

DAB2IP IRAK1 SFRP5

1.67e-0467333GO:0043506
GeneOntologyBiologicalProcessregulation of MAP kinase activity

DAB2IP IRAK1 SFRP5 HYAL2

2.51e-04194334GO:0043405
GeneOntologyBiologicalProcessnegative regulation of MAPK cascade

DAB2IP SFRP5 DMD HYAL2

2.87e-04201334GO:0043409
GeneOntologyBiologicalProcesscellular response to interleukin-1

DAB2IP IRAK1 HYAL2

3.37e-0485333GO:0071347
GeneOntologyBiologicalProcessnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

DAB2IP SFRP5 HYAL2

3.49e-0486333GO:0051898
GeneOntologyBiologicalProcessnegative regulation of protein kinase activity

DAB2IP SFRP5 WNK4 HYAL2

4.11e-04221334GO:0006469
GeneOntologyBiologicalProcessnegative regulation of kinase activity

DAB2IP SFRP5 WNK4 HYAL2

5.27e-04236334GO:0033673
GeneOntologyBiologicalProcessregulation of phosphorylation

DAB2IP EPHB4 IRAK1 PRKDC SFRP5 DMD WNK4 HYAL2

5.56e-041226338GO:0042325
GeneOntologyBiologicalProcessMAPK cascade

DAB2IP IRAK1 SFRP5 DMD MAPK7 WNK4 HYAL2

5.65e-04930337GO:0000165
DomainKinase-like_dom

EPHB4 IRAK1 PRKDC DMD MAPK7 WNK4

2.77e-04542326IPR011009
Pubmed

T and B lymphocyte depletion has a marked effect on the fibrosis of dystrophic skeletal muscles in the scid/mdx mouse.

PRKDC DMD

8.73e-07233217668421
Pubmed

Human muscle-derived cell populations isolated by differential adhesion rates: phenotype and contribution to skeletal muscle regeneration in Mdx/SCID mice.

PRKDC DMD

8.73e-07233221854253
Pubmed

Chemokine/ITGA4 Interaction Directs iPSC-Derived Myogenic Progenitor Migration to Injury Sites in Aging Muscle for Regeneration.

PRKDC DMD

8.73e-07233237508502
Pubmed

Transplantation-based screen identifies inducers of muscle progenitor cell engraftment across vertebrate species.

PRKDC DMD

8.73e-07233237018075
Pubmed

Reversible immortalisation enables genetic correction of human muscle progenitors and engineering of next-generation human artificial chromosomes for Duchenne muscular dystrophy.

PRKDC DMD

2.62e-06333229242210
Pubmed

Dysferlin deficiency enhances monocyte phagocytosis: a model for the inflammatory onset of limb-girdle muscular dystrophy 2B.

IGF2R DMD

2.62e-06333218276788
Pubmed

Cell-mediated exon skipping normalizes dystrophin expression and muscle function in a new mouse model of Duchenne Muscular Dystrophy.

PRKDC DMD

2.62e-06333238438561
Pubmed

Human pluripotent stem cell-derived myogenic progenitors undergo maturation to quiescent satellite cells upon engraftment.

PRKDC DMD

2.62e-06333235395188
Pubmed

OXTRHigh stroma fibroblasts control the invasion pattern of oral squamous cell carcinoma via ERK5 signaling.

PRKDC MAPK7

5.23e-06433236045118
Pubmed

Locus coeruleus neurons are resistant to dysfunction and degeneration by maintaining free ubiquitin levels although total ubiquitin levels decrease upon disruption of polyubiquitin gene Ubb.

PRKDC DMD

5.23e-06433222285186
Pubmed

Gli1 marks a sentinel muscle stem cell population for muscle regeneration.

PRKDC DMD

8.72e-06533237914731
Pubmed

Direct Reprogramming of Mouse Fibroblasts into Functional Skeletal Muscle Progenitors.

PRKDC DMD

1.31e-05633229742392
Pubmed

Mest but Not MiR-335 Affects Skeletal Muscle Growth and Regeneration.

IGF2R DMD

1.31e-05633226098312
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

DAB2IP EPHB4 IRAK1 PRKDC IGF2R MRPL46 SZT2

6.64e-05110533735748872
Pubmed

Myocardial-specific R-spondin3 drives proliferation of the coronary stems primarily through the Leucine Rich Repeat G Protein coupled receptor LGR4.

RNF213 LGR6

1.04e-041633229859889
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

EPHB4 IRAK1 TMEM214 PDE3B PRKDC IGF2R

2.30e-0494233631073040
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

EPHB4 MRPL38 CBARP TMEM214 PDE3B IGF2R MRPL46

4.14e-04148733733957083
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

DAB2IP CBARP IGF2R DMD

6.56e-0442133436976175
Pubmed

p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA-binding ability.

MRPL38 MRPL46

7.00e-044133222904065
Pubmed

Identification of kidney mesenchymal genes by a combination of microarray analysis and Sall1-GFP knockin mice.

SLC22A6 WNK4

9.19e-044733215172686
ToppCellAdult-Mesenchymal-vascular_smooth_muscle_cell-D175|Adult / Lineage, Cell type, age group and donor

DAB2IP FHOD3 CBARP LGR6

6.89e-06167334c4e321bb87512ea839f324c92c0f1afea891483f
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK-Natural_Killer_Cell_/_Natural_Killer_T_Cell-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CNOT6 LRRC66 LGR6 SUCNR1

7.39e-0617033428fb192b21cdc5a77ba4f276694cff852eb2304b
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK-Natural_Killer_Cell_/_Natural_Killer_T_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CNOT6 LRRC66 LGR6 SUCNR1

7.39e-06170334239cb4b801b2d71a6facb386f2684c0851504151
ToppCellPND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRRC66 FHOD3 LGR6 DMD

8.67e-06177334c9b02a2e1ff2aa18c37e88a53b06a5b696a442ae
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6|TCGA-Prostate / Sample_Type by Project: Shred V9

CNOT6 PDE3B PRKDC IGF2R

1.22e-05193334abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCellwk_08-11-Epithelial-Airway_epithelial_progenitor-epi-airway_progenitor_early|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

ESPN USP43 ANKRD65 DMD

1.32e-051973344ae08ccb6f1da626c4f0fb0140a2811cb6e31ba1
ToppCellLPS_IL1RA-Endothelial-Endothelial|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

EPHB4 RNF213 PDE3B HYAL2

1.40e-0520033472ea9882a8ed26fa1534aeb6ba0d1897dccc20c5
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

EPHB4 RNF213 PDE3B HYAL2

1.40e-05200334a1fa6bae5a688faf488d6925cd3fad725dfa916b
ToppCellLPS_IL1RA_TNF-Endothelial|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

EPHB4 RNF213 PDE3B HYAL2

1.40e-05200334d01cec331be3b03cef80e9536fc531285bcf00f6
ToppCellLPS_IL1RA-Endothelial|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

EPHB4 RNF213 PDE3B HYAL2

1.40e-052003345c092b2ecc081b5d04476c56333c338cd89ab984
ToppCellHippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Excitatory_Neuron.Slc17a6.Nell1_(Neuron.Slc17a6.Nell1)|Hippocampus / BrainAtlas - Mouse McCarroll V32

ESPN USP43 LGR6

1.82e-056933311e6747ed4a45acee210c48ba670bfe0375fb19b
ToppCellHippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Excitatory_Neuron.Slc17a6.Nell1_(Neuron.Slc17a6.Nell1)-|Hippocampus / BrainAtlas - Mouse McCarroll V32

ESPN USP43 LGR6

1.82e-056933396564b46008a6e5220b6596cbbe0a24e9b5955ee
ToppCellGlobus_pallidus-Macroglia-POLYDENDROCYTE-P3|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

CNOT6 SUCNR1 MAPK7

6.77e-05107333c41bc8810df67158f0ae9f6015c965a8ebd96965
ToppCellGlobus_pallidus-Macroglia-POLYDENDROCYTE-P3-Tnr|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

CNOT6 SUCNR1 MAPK7

6.77e-0510733360b272f5c89bea8a2714f870e18b7ac89a4a4bf6
ToppCellLPS-antiTNF-Stromal_mesenchymal-Myocytic-Myofibroblast|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FHOD3 LGR6 DMD

1.02e-0412333387401764a073c1808f214642a9c84299c78f7ec7
ToppCellChildren_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

FHOD3 LGR6 DMD

2.03e-04155333cd7d95cbcad248670e531d80bb83c55e36ebc573
ToppCellfacs-Heart-RA-18m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB4 IGF2R HYAL2

2.57e-0416833306dc5b2d356d3a9454b10bba6f3b9ead2a0a7d46
ToppCellfacs-Heart-RA-18m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB4 IGF2R HYAL2

2.57e-041683331002f058a340763e3d8de0bd1f0547a903526ec6
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

USP43 FHOD3 WNK4

2.80e-041733334bc6d93716f093b460c8b047199db8cab5fea720
ToppCelldroplet-Heart-4Chambers-18m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DAB2IP EPHB4 HYAL2

2.80e-041733339a04271c51fae34f547db3206f9ff5857686e45c
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Macrophage-macrophage,_alveolar-Macro_c1-C1QC|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

IRAK1 PLA2G4F HYAL2

2.85e-04174333d77fa525d5c87c190b4a10787b270eabd16c610f
ToppCell10x5'-blood-Lymphocytic_Invariant-Inducer-like-MAIT|blood / Manually curated celltypes from each tissue

DAB2IP FHOD3 PDE3B

2.90e-04175333b4e4b66e89f79999768a6192c8404cb2465f920b
ToppCellPND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRRC66 FHOD3 LGR6

2.99e-041773337ebdcedfe02da6d05bba3d625d8bd4c4ea96e4ad
ToppCelldroplet-Heart-4Chambers-18m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DAB2IP EPHB4 USP43

3.04e-04178333ba2f0585626988b511046630bc16be5c5fec3fb2
ToppCelldroplet-Liver-Npc-18m-Lymphocytic-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CNOT6 PRKDC SZT2

3.04e-0417833309d2687e0d79f12e90af35fc1c0453d249cf2d19
ToppCellPCW_10-12-Neuronal-Neuronal_postreplicative|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

FHOD3 DMD PLXNB3

3.20e-041813331aebb62ed4439db444ee9d30688212b86ee3d9ef
ToppCell5'-GW_trimst-1-SmallIntestine-Epithelial-epithelial_progenitor_cell-Stem_cells|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SFRP5 PIGZ WNK4

3.20e-04181333c7a220891567c7539ad5a9ac9db375f0de08ea00
ToppCellPCW_10-12-Neuronal-Neuronal_postreplicative-neuro_NA|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

FHOD3 DMD PLXNB3

3.20e-041813336aee2ddee4790250ef3b2ef0038bd9839925c995
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

USP43 FHOD3 WNK4

3.20e-04181333e0abf2707d9e0aa942c657eef7d2cbcd02f060dd
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ESPN SLC22A6 FHOD3

3.20e-041813339542c19edc9bd2cba68c01c2a8407705398e3011
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ESPN SLC22A6 FHOD3

3.20e-041813338f04f8cac5d705dc5f6cf6f4516d6e45b0aa4ae5
ToppCellPCW_10-12-Neuronal|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

FHOD3 DMD PLXNB3

3.20e-04181333381b553e2cae65ce6be100662a5f9f963353840c
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25-31|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LGR6 SFRP5 PLXNB3

3.25e-04182333a1c0e4090a9e7aa4941a40c817d178de144888b6
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Macroglial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFRP5 WNK4 PLXNB3

3.25e-04182333c00e503f442d44fbae73c5e2dc85be69e294e67a
ToppCellP03-Epithelial-epithelial_progenitor_cell-epithelial_unknown_3|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ESPN SFRP5 PLXNB3

3.35e-041843338880ff36c243cc60a524d74934d000aef26a70ac
ToppCell5'-Adult-LargeIntestine-Neuronal-Glial_mature|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SFRP5 DMD PLXNB3

3.41e-04185333f607b6ee579562e2f92103fa5c7053df0170a229
ToppCell3'-GW_trimst-1-LargeIntestine-Mesenchymal-mesothelial_cell-Mesothelium_(RGS5+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PDE3B DMD OR10G9

3.41e-0418533311fbea1eb1d9a3e4480d0d2b0f7b02e2866b8142
ToppCell5'-Adult-LargeIntestine-Neuronal|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SFRP5 DMD PLXNB3

3.41e-04185333317f2c854f00aa5957319b818c85eeed7d72ec7f
ToppCell5'-Adult-LargeIntestine-Neuronal-Glial_mature-Adult_Glia|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SFRP5 DMD PLXNB3

3.41e-041853337bb8fdfe04f85d25056380ec58222366de323a21
ToppCell5'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC22A6 DMD PLXNB3

3.46e-041863336f88b68735d0f7c9904eb8413e6007910d556185
ToppCelldroplet-Limb_Muscle-nan-24m-Macroglial-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFRP5 WNK4 PLXNB3

3.46e-04186333ea936e66ae4b7b40564711fad60ac0137327995f
ToppCellfacs-Heart-LA-24m-Mesenchymal-ventricular_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FHOD3 LGR6 SFRP5

3.46e-04186333337f768cc43db2db96ba6495b076006b1a5b0331
ToppCell10x5'-Liver-Myeloid_Dendritic-DC1|Liver / Manually curated celltypes from each tissue

ANKRD65 DMD PIGZ

3.46e-04186333e823529ffd06352c6bdec102f221fdf27f7c7369
ToppCellfacs-Heart-LA-24m-Mesenchymal-ventricular_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FHOD3 LGR6 SFRP5

3.46e-04186333e378c82ef6d6cb24751515aa499a01372b3e7ccf
ToppCellfacs-Heart-LA-24m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGF2R WNK4 HYAL2

3.52e-041873337b13c3b67d66f3afb410141d5471c9e78a4d8623
ToppCellsaliva-Mild-Moderate_progression_d12-25-Epithelial-Epithelial,_Airway-secretory_cell-Epi-Secretory|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DAB2IP USP43 ANKRD65

3.52e-0418733343ef900b76f3c38bd8ce9858201124130c743d56
ToppCelldroplet-Limb_Muscle-nan-24m-Macroglial|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFRP5 WNK4 PLXNB3

3.52e-04187333a0bd2b0ec9e73521c245037b1dd51ff8cf24cbf5
ToppCelldroplet-Limb_Muscle-nan-24m-Macroglial-Schwann_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFRP5 WNK4 PLXNB3

3.52e-04187333f2af79a20438108c814a73f9e24cd986d537237f
ToppCellsaliva-Mild-Moderate_progression_d12-25-Epithelial-Epithelial,_Airway-secretory_cell|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DAB2IP USP43 ANKRD65

3.52e-041873336e5c38425b6b1d4774f8dcea7e146f1eab785c3e
ToppCellfacs-Heart-LA-24m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGF2R WNK4 HYAL2

3.52e-04187333d9943e65eedab73d141eae524e2411653a751705
ToppCellfacs-Heart-RA-3m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB4 IGF2R WNK4

3.57e-041883334ddb11a90bf3baa7237bde304db44dfcc56aed52
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FHOD3 LGR6 DMD

3.57e-041883333177b2c1723268d330d3e9f24f9e24492ace6286
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

RNF213 PDE3B IGF2R

3.57e-04188333ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellfacs-Heart-RA-3m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB4 IGF2R WNK4

3.57e-04188333e47e66906922d5c69b1aafe28face0787d3fc563
ToppCell3'_v3-blood-Myeloid_Dendritic-DC1|blood / Manually curated celltypes from each tissue

ANKRD65 DMD PIGZ

3.57e-04188333411d4dd5c9dee7ebd8db352640cf009e7b033ba9
ToppCelldroplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l32-30|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SFRP5 DMD PLXNB3

3.57e-04188333502045a39ffb1e92bd9499848368e8fa971edb88
ToppCellfacs-Trachea-nan-3m-Mesenchymal-smooth_muscle_cell_of_trachea|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFRP5 DMD PLXNB3

3.57e-04188333794fc1d9a726945c42f7eac221eed938309b47a9
ToppCellfacs-Heart-RA-24m-Mesenchymal-ventricular_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FHOD3 LGR6 SFRP5

3.63e-04189333b98f60875b1a12b2ec9dc91889298ae57f98602f
ToppCellfacs-Heart-RA-24m-Mesenchymal-ventricular_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FHOD3 LGR6 SFRP5

3.63e-04189333e758b264c0a47127e33e66c395cf5a3224c7305b
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

USP43 FHOD3 WNK4

3.63e-04189333977a813e5d7a5a561c1fced2bbf21c20056b88d8
ToppCelldroplet-Heart-nan-3m-Endothelial-endocardial_endothelial_cells|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGF2R WNK4 HYAL2

3.63e-04189333fb2253b8463d08b3d28e952a31a23dea2c2d986b
ToppCell3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell-Neuroendocrine|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ESPN SUCNR1 PKD1L3

3.68e-0419033340d8b3403f4e38436b961cd3a2e69826cbae3042
ToppCell3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell-Neuroendocrine-Neuroendocrine_L.0.7.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ESPN SUCNR1 PKD1L3

3.68e-04190333f6cbf6d292f488ada5f7581e1dceba6198b933d1
ToppCelldroplet-Heart-nan-24m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB4 WNK4 HYAL2

3.68e-041903337068754c29f63a331e2b6c54715f3b26f37ad32b
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells-CD8_T_cells_L.1.1.4.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RNF213 PDE3B LGR6

3.68e-04190333d153a0bdedcd6865e6ee19575234a78b5d859ff1
ToppCell3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ESPN SUCNR1 PKD1L3

3.68e-04190333a9a705455019e28d655636de73b07540798f82e6
ToppCelldroplet-Heart-4Chambers-18m-Endothelial-endocardial_endothelial_cells|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLA2G4F WNK4 HYAL2

3.68e-041903336f71a9f74af7cd9a674753cfc9833ebe5bba0fa2
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

USP43 FHOD3 WNK4

3.68e-04190333e252e925600e6457fa6e362a55217f4cffa75cdb
ToppCellfacs-Heart-RV-3m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB4 WNK4 HYAL2

3.74e-04191333e518c598719119e60c76016c586b1520c258bbcb
ToppCellControl-Stromal_mesenchymal|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FHOD3 LGR6 DMD

3.74e-0419133314057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FHOD3 LGR6 DMD

3.74e-04191333b133ee1c0e58d00ddd2e4e05b01fd04947524c18
ToppCelldroplet-Heart-HEART-1m-Endothelial-endocardial_endothelial_cells|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGF2R WNK4 HYAL2

3.74e-041913334bfdf44d4402a42530d30c89d94946acdda4321b
ToppCellfacs-Heart-RV-3m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB4 WNK4 HYAL2

3.74e-04191333f0c649bb32732c9dd38a0af8ce94d2a4d16de39a
ToppCelldroplet-Lung-18m-Mesenchymal-myofibroblast|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FHOD3 LGR6 DMD

3.80e-041923332cc712186e37fb21a964c032765c36a8b4a852cf
ToppCellVE-mDC1|VE / Condition, Cell_class and T cell subcluster

ANKRD65 DMD PIGZ

3.86e-0419333312b2708db9db8b88365b8ebeb4908f28c50081bb
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-goblet|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PLA2G4F PIGZ WNK4

3.86e-04193333402aad2f9e789ad1f2e1536cdc9ce61de7625427
ToppCellVE-mDC1-|VE / Condition, Cell_class and T cell subcluster

ANKRD65 DMD PIGZ

3.86e-041933335df6033bc0e4f96a20d526486a8e89c990e21831
ToppCelldroplet-Heart-HEART-1m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB4 IGF2R HYAL2

3.86e-04193333d0a5f212f8e8a13dbbe3e41df92548ef82eef70b
ToppCell(07)_Brush|World / shred by cell type and Timepoint

EPHB4 ESPN SUCNR1

3.86e-041933339af9d22a130ff97a9c37142a65e841b056d08640
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-goblet-Goblet_cell|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PLA2G4F PIGZ WNK4

3.86e-041933337ee3b1ef5c455f321b4e154ae62c69543fe9b30e
ToppCell3'-Child04-06-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

EPHB4 ANKRD65 HYAL2

3.97e-04195333527a5a50d6e2cbbbd64d11609e5cde2e33f14797
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGF2R WNK4 HYAL2

4.03e-041963337d5eaed189aa6116f3799be010139fb675ec65e0
ToppCelldroplet-Heart-nan-18m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB4 IGF2R WNK4

4.03e-04196333e386526332138e636aef2542c11316347a45689c
ToppCellBronchial-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FHOD3 LGR6 PLXNB3

4.03e-041963339830fb3da7a60f65ad463e9054bb77c06b025e4d
ToppCell3'-Child09-12-SmallIntestine-Endothelial-blood_vessel_EC|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

EPHB4 ANKRD65 HYAL2

4.03e-04196333a0ba408b802fa6d6e42e6d234b6879fdb1583f81
ToppCelldistal-3-Epithelial-Ionocyte|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ESPN FHOD3 PIGZ

4.03e-041963336ed146481dd04fb271eadc47d68eb3ae38986db6
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-endocardial_endothelial_cells|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGF2R WNK4 HYAL2

4.03e-04196333dbf154b3d166ffd07be717dac8d8a3350ac63e16
ToppCellBronchial-NucSeq-Stromal-Schwann|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CBARP SFRP5 PLXNB3

4.03e-04196333a90c76d9c57a4491b94a321ba541b792ec5d8e83
ToppCellCOVID-19_Severe-NK|World / disease group, cell group and cell class

RNF213 LGR6 IGF2R

4.03e-04196333f46ca7cc2d8407d0dcaa77c4b16a2c1f2a23734d
ToppCellBL|World / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

RNF213 PDE3B IGF2R

4.09e-041973331acf0191fa0a25cd20bfd9ea7bf727a1555986a1
ToppCellmild-low-quality_cells|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

RNF213 LRRC66 PDE3B

4.09e-04197333e4331969bd911d1ebb5453f40a7057297b5389b4
ToppCelldistal-Epithelial-Ionocyte-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ESPN FHOD3 PIGZ

4.09e-041973337a2cd970fe0866057999e40d15367b2b3324ae59
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

USP43 DMD WNK4

4.09e-0419733374a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCelldistal-Epithelial-Ionocyte|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ESPN FHOD3 PIGZ

4.09e-0419733311a5d2db2561d045756980ead61e1211c7dda100
ToppCell3'-Child09-12-SmallIntestine-Endothelial-blood_vessel_EC-arterial_capillary|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

EPHB4 ANKRD65 HYAL2

4.09e-04197333947042f888335c0829d4d5daeb623973eadb3348
ToppCellBronchial-NucSeq-Stromal-Schwann-Schwann_nonmyelinating|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CBARP SFRP5 PLXNB3

4.09e-041973334a7ff67bb0754e034e6f2a1bd34cde86ee3ef899
ToppCellTracheal-10x5prime-Stromal-Schwann-Schwann_nonmyelinating|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SFRP5 DMD PLXNB3

4.09e-04197333e239caae24f40564a24ad909754f5436f767ccdb
ToppCellhealthy_donor-Lymphocytic-ILC-NK_cell|healthy_donor / Disease condition, Lineage, Cell class and subclass

RNF213 LGR6 IGF2R

4.16e-04198333d7053a898e04478c577381085f615edaad3cdc5b
ToppCellhealthy_donor-Lymphocytic-ILC|healthy_donor / Disease condition, Lineage, Cell class and subclass

RNF213 LGR6 IGF2R

4.16e-04198333aa33be29e26f1b8facfc894413099083ae3bbb1b
ToppCellCOVID_non-vent-Lymphocytic-ILC|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

RNF213 LGR6 IGF2R

4.22e-04199333df4f7d5be099e3e6054f3b812ccf70251664e4c0
DiseaseMetastatic melanoma

EPHB4 PRKDC WNK4

2.27e-0554303C0278883
DiseaseVentricular Dysfunction

IGF2R DMD

2.79e-058302C0242973
Diseaseperiodontitis

DAB2IP FHOD3 IGF2R DMD

7.46e-05223304EFO_0000649
DiseaseMicrocalcification

SLC22A6 DMD

8.39e-0442302C0521174
DiseaseCalcinosis

SLC22A6 DMD

8.39e-0442302C0006663
DiseaseTumoral calcinosis

SLC22A6 DMD

8.39e-0442302C0263628
Diseasedevelopmental disorder of mental health (implicated_via_orthology)

DAB2IP PLXNB3

1.14e-0349302DOID:0060037 (implicated_via_orthology)
Diseaseesophagus squamous cell carcinoma (is_marker_for)

DAB2IP EPHB4

2.58e-0374302DOID:3748 (is_marker_for)
DiseaseLung diseases

PRKDC IGF2R

2.86e-0378302C0024115
Diseasesleep duration, low density lipoprotein cholesterol measurement

IGF2R PKD1L3

3.87e-0391302EFO_0004611, EFO_0005271
Diseasefactor VIII measurement, coronary artery disease

DAB2IP IGF2R

5.90e-03113302EFO_0001645, EFO_0004630
Diseasecoronary artery disease

DAB2IP USP43 RNF213 IGF2R PKD1L3

6.60e-031194305EFO_0001645

Protein segments in the cluster

PeptideGeneStartEntry
DLWSLRASLELHAAA

CBARP

436

Q8N350
TSWSDGLALNALIHS

DMD

161

P11532
IDLGRELSSLHSLLW

DAB2IP

611

Q5VWQ8
ASLSASLLADWLEGH

MAPK7

771

Q13164
LLSLRTHSSEGRWKA

OR4C15

221

Q8NGM1
EAWAGSHLTSLLALA

HYAL2

451

Q12891
VSRLNGSSLHLEWSA

EPHB4

331

P54760
RSFEGLSSLRHLWLD

LGR6

156

Q9HBX8
LSWLLLHGGEISADL

ESPN

256

B1AK53
LEWRSGLAGHLTLSD

PLXNB3

1576

Q9ULL4
AWLRTLLSVCSHSLS

PDE3B

106

Q13370
LLSSHWEARLLQGSL

LMLN2

381

A0A1B0GTW7
WAAALGHTLLAARLL

ANKRD65

146

E5RJM6
SLGGLSAALRSWHLT

IRAK1

591

P51617
RSGHSVSLIDLWGLL

PLA2G4F

451

Q68DD2
IHSLSLDLLSPKSSW

LRRC66

121

Q68CR7
TLSSISELSARLHLW

FHOD3

1036

Q2V2M9
SARWHSSSGRLDLTL

SLC22A6

271

Q4U2R8
RSLSASLWSLTHLTA

CNOT6

41

Q9ULM6
SLWSLTHLTALHLSD

CNOT6

46

Q9ULM6
ALLATSTWLSGSLHS

OR10G9

141

Q8NGN4
RLLSSLTGSWSLVHN

IGF2R

2006

P11717
RISHSSLTSLLRDWS

SZT2

611

Q5T011
RLWAGSLSSRSLALA

MRPL46

21

Q9H2W6
RTAALALLLGALHWA

SFRP5

11

Q5T4F7
LLTTWTSLGNLHSLR

PKD1L3

796

Q7Z443
LLEGSLDWLCHLLTS

RNF213

636

Q63HN8
TSSSLSDHWLLRLGS

USP43

726

Q70EL4
GSLWTLLLTSLDGHL

MRPL38

211

Q96DV4
GASLISSRWLLSAAH

TMPRSS11B

211

Q86T26
LSQSSLLLEHLLSSW

TMEM214

411

Q6NUQ4
LSSLLSGAWRDHLSL

PIGZ

556

Q86VD9
SLTSFSRWAHELLLS

SUCNR1

316

Q9BXA5
DRSLLTLLWHCSLDA

PRKDC

1821

P78527
RRSSVDLGLLSSWSL

WNK4

61

Q96J92