Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionG protein-coupled receptor activity

FZD9 OR2A14 OR2L8 MRGPRD TAS1R3 OR1Q1 OR6Q1 OR6J1 OR4D1 FZD10 CCKBR OR10D4P

5.91e-068845712GO:0004930
GeneOntologyMolecularFunctionhistone binding

TSPY3 TSPY10 TSPY2 CHD4 TSPY8 TSPY1

1.06e-04265576GO:0042393
GeneOntologyMolecularFunctionolfactory receptor activity

OR2A14 OR2L8 OR1Q1 OR6Q1 OR6J1 OR4D1 OR10D4P

2.17e-04431577GO:0004984
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

FZD9 OR2A14 OR2L8 MRGPRD TAS1R3 OR1Q1 OR6Q1 OR6J1 OR4D1 FZD10 CCKBR OR10D4P

3.64e-0413535712GO:0004888
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

CACNA1F SLC8A3 CNGB1 RYR1

9.09e-04151574GO:0015085
GeneOntologyMolecularFunctionWnt receptor activity

FZD9 FZD10

1.06e-0317572GO:0042813
GeneOntologyBiologicalProcessgonadal mesoderm development

TSPY3 TSPY10 TSPY2 TSPY8 TSPY1

1.54e-119565GO:0007506
GeneOntologyBiologicalProcessdetection of stimulus

OR2A14 CACNA1F OR2L8 TAS1R3 OR1Q1 OR6Q1 PIEZO1 OR6J1 OR4D1 CNGB1 OR10D4P

3.17e-067225611GO:0051606
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

OR2A14 CACNA1F OR2L8 TAS1R3 OR1Q1 OR6Q1 OR6J1 OR4D1 CNGB1 OR10D4P

3.28e-065825610GO:0050906
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception

OR2A14 OR2L8 TAS1R3 OR1Q1 OR6Q1 OR6J1 OR4D1 CNGB1 OR10D4P

5.79e-06485569GO:0050907
GeneOntologyBiologicalProcessdetection of chemical stimulus

OR2A14 OR2L8 TAS1R3 OR1Q1 OR6Q1 OR6J1 OR4D1 CNGB1 OR10D4P

1.08e-05524569GO:0009593
GeneOntologyBiologicalProcesssensory perception of chemical stimulus

OR2A14 OR2L8 TAS1R3 OR1Q1 OR6Q1 OR6J1 OR4D1 CNGB1 OR10D4P

1.52e-05547569GO:0007606
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

FZD9 OR2A14 OR2L8 MRGPRD TAS1R3 OR1Q1 OR6Q1 OR6J1 OR4D1 FZD10 GIT2 CNGB1 CCKBR OR10D4P

1.54e-0513955614GO:0007186
GeneOntologyBiologicalProcessnucleosome assembly

TSPY3 TSPY10 TSPY2 TSPY8 TSPY1

2.00e-05122565GO:0006334
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of smell

OR2A14 OR2L8 OR1Q1 OR6Q1 OR6J1 OR4D1 CNGB1 OR10D4P

2.04e-05432568GO:0050911
GeneOntologyBiologicalProcesssensory perception of smell

OR2A14 OR2L8 OR1Q1 OR6Q1 OR6J1 OR4D1 CNGB1 OR10D4P

3.45e-05465568GO:0007608
GeneOntologyBiologicalProcessnucleosome organization

TSPY3 TSPY10 TSPY2 TSPY8 TSPY1

4.15e-05142565GO:0034728
GeneOntologyBiologicalProcessmesoderm development

TSPY3 TSPY10 TSPY2 TSPY8 TSPY1

6.69e-05157565GO:0007498
GeneOntologyBiologicalProcesssensory perception

OR2A14 CACNA1F OR2L8 TAS1R3 OR1Q1 OR6Q1 OR6J1 OR4D1 KCNMA1 CNGB1 OR10D4P

1.22e-0410725611GO:0007600
DomainNAP

TSPY10 TSPY2 TSPY8

1.60e-0517553PF00956
DomainNAP_family

TSPY10 TSPY2 TSPY8

1.60e-0517553IPR002164
DomainIon_trans_dom

CACNA1F KCNMA1 CNGB1 RYR1

3.53e-04114554IPR005821
DomainIon_trans

CACNA1F KCNMA1 CNGB1 RYR1

3.53e-04114554PF00520
DomainFrizzled

FZD9 FZD10

4.60e-0411552IPR000539
DomainFrizzled

FZD9 FZD10

4.60e-0411552PF01534
DomainFrizzled

FZD9 FZD10

4.60e-0411552SM01330
Domain7tm_1

OR2A14 OR2L8 MRGPRD OR1Q1 OR6Q1 OR6J1 OR4D1 CCKBR

7.72e-04677558PF00001
DomainG_PROTEIN_RECEP_F1_1

OR2A14 OR2L8 MRGPRD OR1Q1 OR6Q1 OR6J1 OR4D1 CCKBR

8.34e-04685558PS00237
DomainG_PROTEIN_RECEP_F1_2

OR2A14 OR2L8 MRGPRD OR1Q1 OR6Q1 OR6J1 OR4D1 CCKBR

8.82e-04691558PS50262
DomainGPCR_Rhodpsn

OR2A14 OR2L8 MRGPRD OR1Q1 OR6Q1 OR6J1 OR4D1 CCKBR

8.90e-04692558IPR000276
DomainFrizzled/SFRP

FZD9 FZD10

9.95e-0416552IPR015526
DomainOlfact_rcpt

OR2A14 OR2L8 OR1Q1 OR6Q1 OR6J1 OR4D1

1.01e-03393556IPR000725
DomainFRI

FZD9 FZD10

1.56e-0320552SM00063
Domain-

FZD9 FZD10

1.72e-03215521.10.2000.10
DomainFrizzled_dom

FZD9 FZD10

2.25e-0324552IPR020067
DomainFZ

FZD9 FZD10

2.25e-0324552PS50038
DomainFz

FZD9 FZD10

2.25e-0324552PF01392
DomainGPCR_Rhodpsn_7TM

OR2A14 OR2L8 MRGPRD OR1Q1 OR6Q1 OR4D1 CCKBR

3.37e-03670557IPR017452
DomainSNF2_N

CHD4 HELLS

3.99e-0332552PF00176
DomainSNF2_N

CHD4 HELLS

3.99e-0332552IPR000330
PathwayREACTOME_SENSORY_PERCEPTION

OR2A14 OR2L8 TAS1R3 OR1Q1 OR6Q1 OR6J1 OR4D1 KCNMA1 CNGB1

4.59e-05636399M41834
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR2A14 OR2L8 OR1Q1 OR6Q1 OR6J1 OR4D1 CNGB1

1.28e-04417397M4072
Pubmed

Piezo1 and BKCa channels in human atrial fibroblasts: Interplay and remodelling in atrial fibrillation.

PIEZO1 KCNMA1

2.73e-06258233974928
Pubmed

Voltage-dependent Ca2+ channels, not ryanodine receptors, activate Ca2+-dependent BK potassium channels in human retinal pigment epithelial cells.

KCNMA1 RYR1

2.73e-06258219096717
Pubmed

PIEZO1 transduces mechanical itch in mice.

MRGPRD PIEZO1

2.72e-05558235732741
Pubmed

Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.

CACNA1F SLC8A3 RYR1

3.56e-053858330786075
Pubmed

Wnt receptors and Wnt inhibitors are expressed in gradients in the developing telencephalon.

FZD9 FZD10

5.71e-05758211335128
Pubmed

A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.

FZD9 FZD10

9.77e-0595829707618
Pubmed

Expression of Frizzled genes in developing and postnatal hair follicles.

FZD9 FZD10

1.22e-041058215245425
Pubmed

The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer.

BMP2K TCF25 CHD4 GIT2 HELLS

1.41e-0429858530737378
Pubmed

Frizzled-9 impairs acetylcholine receptor clustering in skeletal muscle cells.

FZD9 FZD10

1.49e-041158224860427
Pubmed

Distinct but redundant expression of the Frizzled Wnt receptor genes at signaling centers of the developing mouse brain.

FZD9 FZD10

1.49e-041158217582687
Pubmed

Expression of Frizzled5, Frizzled7, and Frizzled10 during early mouse development and interactions with canonical Wnt signaling.

FZD9 FZD10

1.49e-041158217576136
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR2A14 OR2L8 OR1Q1 OR4D1 OR10D4P

2.60e-0434058511875048
Pubmed

The olfactory receptor gene superfamily of the mouse.

OR2A14 OR2L8 OR1Q1 OR4D1 OR10D4P

2.60e-0434058511802173
Pubmed

A unified nomenclature for vertebrate olfactory receptors.

OR2A14 OR2L8 OR1Q1 OR4D1 OR10D4P

2.71e-0434358532295537
Pubmed

The human olfactory receptor gene family.

OR2A14 OR2L8 OR1Q1 OR6Q1 OR4D1 OR10D4P

2.81e-0454158614983052
Pubmed

Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.

OR2A14 OR2L8 OR1Q1 OR4D1 OR10D4P

2.82e-0434658514611657
Pubmed

TMEM79/MATTRIN defines a pathway for Frizzled regulation and is required for Xenopus embryogenesis.

FZD9 FZD10

4.11e-041858232924931
Pubmed

DEFOG: a practical scheme for deciphering families of genes.

OR2A14 OR1Q1 OR6Q1 OR4D1

4.97e-0421958412213199
Pubmed

Expression of the Wnt inhibitor Dickkopf-1 is required for the induction of neural markers in mouse embryonic stem cells differentiating in response to retinoic acid.

FZD9 FZD10

6.18e-042258217064353
Pubmed

Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.

VPS18 ATP6V1H DYRK1B GIT2 MRRF HELLS

7.10e-0464558625281560
Pubmed

Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species.

OR1Q1 OR4D1

7.37e-04245829119360
Pubmed

3D representation of Wnt and Frizzled gene expression patterns in the mouse embryo at embryonic day 11.5 (Ts19).

FZD9 FZD10

1.08e-032958218364260
Pubmed

A probabilistic classifier for olfactory receptor pseudogenes.

OR2L8 OR6Q1

1.57e-033558216939646
Pubmed

A mutually stimulating loop involving emx2 and canonical wnt signalling specifically promotes expansion of occipital cortex and hippocampus.

FZD9 FZD10

1.66e-033658215800025
Pubmed

Wnt/Rspondin/β-catenin signals control axonal sorting and lineage progression in Schwann cell development.

FZD9 FZD10

1.66e-033658224151333
InteractionTSPY8 interactions

TSPY3 TSPY2 TSPY8

1.53e-083513int:TSPY8
CytobandYp11.2

TSPY3 TSPY10 TSPY2 TSPY8 TSPY1

1.36e-0794585Yp11.2
CytobandEnsembl 112 genes in cytogenetic band chrYp11

TSPY3 TSPY10 TSPY2 TSPY8 TSPY1

1.39e-06150585chrYp11
Cytoband10q24.2

PYROXD2 HELLS

3.57e-042258210q24.2
Cytoband9q33.2

OR1Q1 MRRF

1.13e-03395829q33.2
Cytoband16q24.3

PIEZO1 TCF25

2.00e-035258216q24.3
GeneFamilyG protein-coupled receptors, Class F frizzled

FZD9 FZD10

2.22e-0411372286
GeneFamilyOlfactory receptors, family 6

OR6Q1 OR6J1

4.88e-0351372153
DiseaseMale sterility

KMT2D TAS1R3 DROSHA

7.50e-0548503C0917731
DiseaseMale infertility

KMT2D TAS1R3 DROSHA

7.50e-0548503C0021364
DiseaseSubfertility, Male

KMT2D TAS1R3 DROSHA

7.50e-0548503C0848676
Diseaseasymmetric dimethylarginine measurement

PYROXD2 MTHFS

2.53e-0414502EFO_0010463

Protein segments in the cluster

PeptideGeneStartEntry
QMELYHALPFFCFLL

ALG6

201

Q9Y672
YQMLAFVHRLPCRDD

GIT2

111

Q14161
NPLVYCFMHRRFRQA

CCKBR

386

P32239
YSRNIHCLIRFMLEP

BMP2K

286

Q9NSY1
MFRNHLCLVFELLSY

DYRK1B

181

Q9Y463
LELFLGRMHKTCYFL

CACNA1F

256

O60840
RLAHFLLMFYQEMPC

MGAT4C

271

Q9UBM8
KICFIPRYRFQSNHM

MTHFS

76

P49914
RYADICHPLRYNSLM

OR2A14

121

Q96R47
FPLRYTVIMNHRVCF

OR10D4P

126

Q8NGN7
LMDYCHLRDFNFSRL

HELLS

631

Q9NRZ9
NMLCFGIYRLRDAHL

KCNMA1

1131

Q12791
RYIAICFPLHYLIRM

OR2L8

121

Q8NGY9
MLYVRRVCFFRGHLD

PRAMEF18

271

Q5VWM3
IYSMRFCPYSHRTRL

GSTO2

26

Q9H4Y5
LLGFRMHRNPFCIYI

MRGPRD

51

Q8TDS7
MHRNPFCIYILNLAA

MRGPRD

56

Q8TDS7
MLRYAIAFPLICAHF

NCKAP1L

561

P55160
RLRRPMYFFLTHLSC

OR6Q1

56

Q8NGQ2
QRYILENHDFRAMCP

RFPL4B

36

Q6ZWI9
VPCTQLSMSFFHRLY

CFAP300

101

Q9BRQ4
GHLRFFLCSLYAPMC

FZD10

81

Q9ULW2
SHLRFFLCSLYAPMC

FZD9

86

O00144
CRLYDMRLSPFHLQL

C2CD2

151

Q9Y426
RAMELCSHERLFQPY

ERN1

946

O75460
RFQCGYVLLHLFNRM

MARCHF11

366

A6NNE9
FLFYRHCRYFPMLLN

B3GNT7

111

Q8NFL0
FKAYVSLFMRHLCEP

CHD4

1456

Q14839
LYNLPTHRACNMFLE

RYR1

3641

P21817
ELRFLPFNMHVRYCV

CFAP47

2086

Q6ZTR5
FDCRLHTPMYFLLRN

OR4D1

51

Q15615
DNRIPHFFCDLYALM

OR1Q1

171

Q15612
CRPMTNNAGRLFHYR

DROSHA

561

Q9NRR4
AFSPQMCEHLRRYNI

ATP6V1H

251

Q9UI12
LYNFLRFCEMLIKRP

MITD1

131

Q8WV92
KCFRMVHPTFRNYLA

MRRF

6

Q96E11
CSRLHTPMYFFLCNL

OR6J1

51

Q8NGC5
SQLPRCHRNVFRYLM

OCRL

826

Q01968
LRLPRCLKYMAFFEF

CNGB1

761

Q14028
LMARDLLQPHRLYCY

POGLUT3

446

Q7Z4H8
VHLCKIMLFFRSNPY

TSPY10

196

P0CW01
VHLCKIMLFFRSNPY

TSPY2

196

A6NKD2
LAAFHLPRCYLLMRQ

TAS1R3

806

Q7RTX0
VHLCKIMLFFRSNPY

TSPY1

196

Q01534
PMFCHSDEYFRQLLR

SNX14

456

Q9Y5W7
FHCAMSLDQLYFARP

PYROXD2

521

Q8N2H3
LRRALFNYVHCMFGI

SESN3

401

P58005
RPLFHKLRYQLLCSM

SPDYE4

191

A6NLX3
LNRPFYLFLCGHMFH

VPS18

861

Q9P253
VHLCKIMLFFRSNPY

TSPY3

196

P0CV98
VHLCKIMLFFRSNPY

TSPY8

196

P0CW00
MALFFHRSQLLCYGL

PIEZO1

1791

Q92508
MNEFYHCFLPAEERR

LCMT2

271

O60294
RRPYSCHELFGFDIM

TTLL4

881

Q14679
DFRMHFMNYQRPTLC

ZYG11A

741

Q6WRX3
RALYSMECAFHPLFS

TCF25

311

Q9BQ70
FRESVPMHTCARYLF

ZSWIM4

536

Q9H7M6
RMRCPNVYHFACAIR

KMT2D

5106

O14686
EERLPSCFDYVMHFL

SLC8A3

721

P57103