Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	enoyl-[acyl-carrier-protein] reductase activity (NAD(P)H)	FASN MECR	3.52e-05	2	119	2	GO:0016631
GeneOntologyMolecularFunction	enoyl-[acyl-carrier-protein] reductase (NADPH) activity	FASN MECR	3.52e-05	2	119	2	GO:0141148
GeneOntologyMolecularFunction	guanyl-nucleotide exchange factor activity	DENND3 ARHGEF10L FARP2 RAB3GAP1 ARHGEF10 EIF2B5 HERC2 FGD6	7.40e-05	231	119	8	GO:0005085
GeneOntologyMolecularFunction	1-phosphatidylinositol binding	SNAP91 SCIN WDFY1	1.32e-04	17	119	3	GO:0005545
Domain	WD40_repeat_dom	SEH1L WDR64 TBL1Y TBL1XR1 DENND3 ARHGEF10L PWP1 AAAS ARHGEF10 TECPR2 EML1 CDC20 WDFY1	5.54e-08	297	119	13	IPR017986
Domain	WD40_repeat	SEH1L WDR64 TBL1Y TBL1XR1 DENND3 PWP1 AAAS TECPR2 EML1 HERC2 CDC20 WDFY1	1.70e-07	272	119	12	IPR001680
Domain	-	SEH1L WDR64 TBL1Y TBL1XR1 DENND3 ARHGEF10L PWP1 AAAS ARHGEF10 TECPR2 EML1 CDC20 WDFY1	2.08e-07	333	119	13	2.130.10.10
Domain	WD_REPEATS_1	SEH1L WDR64 TBL1Y TBL1XR1 DENND3 PWP1 AAAS TECPR2 EML1 HERC2 CDC20 WDFY1	2.15e-07	278	119	12	PS00678
Domain	WD40/YVTN_repeat-like_dom	SEH1L WDR64 TBL1Y TBL1XR1 DENND3 ARHGEF10L PWP1 AAAS ARHGEF10 TECPR2 EML1 CDC20 WDFY1	2.23e-07	335	119	13	IPR015943
Domain	WD_REPEATS_2	SEH1L WDR64 TBL1Y TBL1XR1 DENND3 PWP1 AAAS TECPR2 EML1 HERC2 CDC20 WDFY1	2.24e-07	279	119	12	PS50082
Domain	WD_REPEATS_REGION	SEH1L WDR64 TBL1Y TBL1XR1 DENND3 PWP1 AAAS TECPR2 EML1 HERC2 CDC20 WDFY1	2.24e-07	279	119	12	PS50294
Domain	WD40	SEH1L WDR64 TBL1Y TBL1XR1 DENND3 PWP1 AAAS TECPR2 EML1 CDC20 WDFY1	1.16e-06	268	119	11	SM00320
Domain	N2O_reductase_N	SEH1L AAAS EML1 CDC20	2.03e-06	15	119	4	IPR011045
Domain	WD40	SEH1L WDR64 TBL1Y TBL1XR1 DENND3 PWP1 AAAS EML1 CDC20 WDFY1	6.25e-06	259	119	10	PF00400
Domain	WD40_repeat_CS	TBL1Y TBL1XR1 DENND3 PWP1 AAAS CDC20 WDFY1	8.70e-05	164	119	7	IPR019775
Domain	TECPR	TECPR2 HERC2	1.20e-04	3	119	2	SM00706
Domain	Beta-propeller_rpt_TECPR	TECPR2 HERC2	1.20e-04	3	119	2	IPR006624
Domain	ZF_ZZ_2	MIB2 HERC2 DMD	1.92e-04	18	119	3	PS50135
Domain	ZF_ZZ_1	MIB2 HERC2 DMD	1.92e-04	18	119	3	PS01357
Domain	ZZ	MIB2 HERC2 DMD	1.92e-04	18	119	3	PF00569
Domain	G-protein_beta_WD-40_rep	SEH1L TBL1Y TBL1XR1 PWP1 WDFY1	2.11e-04	85	119	5	IPR020472
Domain	Znf_ZZ	MIB2 HERC2 DMD	2.27e-04	19	119	3	IPR000433
Domain	ZnF_ZZ	MIB2 HERC2 DMD	2.27e-04	19	119	3	SM00291
Domain	Mib_Herc2	MIB2 HERC2	2.40e-04	4	119	2	IPR010606
Domain	MIB_HERC2	MIB2 HERC2	2.40e-04	4	119	2	PS51416
Domain	MIB_HERC2	MIB2 HERC2	2.40e-04	4	119	2	PF06701
Domain	RhoGEF	ARHGEF10L FARP2 ARHGEF10 FGD6	9.32e-04	68	119	4	SM00325
Domain	SAM_1	SFMBT1 ARAP1 EPHA1 L3MBTL4	9.32e-04	68	119	4	PF00536
Domain	RhoGEF	ARHGEF10L FARP2 ARHGEF10 FGD6	1.04e-03	70	119	4	PF00621
Domain	DH_2	ARHGEF10L FARP2 ARHGEF10 FGD6	1.04e-03	70	119	4	PS50010
Domain	-	ARHGEF10L FARP2 ARHGEF10 FGD6	1.10e-03	71	119	4	1.20.900.10
Domain	DH-domain	ARHGEF10L FARP2 ARHGEF10 FGD6	1.10e-03	71	119	4	IPR000219
Domain	DHC_N1	DNAH8 DNAH9	1.10e-03	8	119	2	PF08385
Domain	Dynein_heavy_dom-1	DNAH8 DNAH9	1.10e-03	8	119	2	IPR013594
Domain	MBT	SFMBT1 L3MBTL4	1.41e-03	9	119	2	SM00561
Domain	MBT	SFMBT1 L3MBTL4	1.41e-03	9	119	2	PS51079
Domain	LisH	TBL1Y TBL1XR1	1.41e-03	9	119	2	PF08513
Domain	MBT	SFMBT1 L3MBTL4	1.75e-03	10	119	2	PF02820
Domain	Mbt	SFMBT1 L3MBTL4	1.75e-03	10	119	2	IPR004092
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	RAB23 ABCC4 NCBP1 URB2 ACVR1B TBL1XR1 AAAS ARHGEF10 MMS19 TMEM102 HERC2 FZD2 FGD6	1.30e-06	719	120	13	35337019
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	SEH1L ORC3 ELP1 GTF3C3 PWP1 AAAS MMS19 HERC2 CDC20 KPNA1	3.19e-06	440	120	10	34244565
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	RAB23 SEH1L ABCC4 SPG11 ANKRD46 AAAS OSBPL1A TMEM131L SCIN DOP1B	1.05e-05	504	120	10	34432599
Pubmed	Genetic Analysis of Human Chymotrypsin-Like Elastases 3A and 3B (CELA3A and CELA3B) to Assess the Role of Complex Formation between Proelastases and Procarboxypeptidases in Chronic Pancreatitis.	CELA3B CELA3A	1.18e-05	2	120	2	27999401
Pubmed	Common genetic variants associated with melanoma risk or naevus count in patients with wildtype MC1R melanoma.	MC1R HERC2	1.18e-05	2	120	2	35701387
Pubmed	Angiotensin II type 1 receptor blockade attenuates TGF-beta-induced failure of muscle regeneration in multiple myopathic states.	FBN1 DMD	1.18e-05	2	120	2	17237794
Pubmed	Sequence variation in promoter of Ica1 gene, which encodes protein implicated in type 1 diabetes, causes transcription factor autoimmune regulator (AIRE) to increase its binding and down-regulate expression.	ICA1 AIRE	1.18e-05	2	120	2	22447927
Pubmed	GRAF1 deficiency blunts sarcolemmal injury repair and exacerbates cardiac and skeletal muscle pathology in dystrophin-deficient mice.	ARHGAP26 DMD	1.18e-05	2	120	2	26301073
Pubmed	Molecular cloning of complementary DNA encoding one of the human pancreatic protease E isozymes.	CELA3B CELA3A	1.18e-05	2	120	2	2460440
Pubmed	Duchenne-like myopathy in double-mutant mdx mice expressing exaggerated mast cell activity.	FBN1 DMD	1.18e-05	2	120	2	7561939
Pubmed	Activation of ryanodine receptor/Ca2+ release channels downregulates CD38 in the Namalwa B lymphoma.	RYR1 CD38	1.18e-05	2	120	2	14596927
Pubmed	Identification of a novel class of elastase isozyme, human pancreatic elastase III, by cDNA and genomic gene cloning.	CELA3B CELA3A	1.18e-05	2	120	2	2826474
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	EPPK1 ELP1 NCBP1 URB2 GTF3C3 PWP1 NEFL FASN URB1 ATAD3A HERC2	1.72e-05	653	120	11	22586326
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	ELP1 URB2 GTF3C3 SLC7A1 FASN RAB3GAP1 URB1 AAAS APH1A ATAD3A EIF2B5 UGGT2 MMS19	2.36e-05	942	120	13	31073040
Pubmed	Dynamic and coordinated expression profile of dbl-family guanine nucleotide exchange factors in the developing mouse brain.	ARHGEF10L FARP2 ARHGEF10	3.15e-05	18	120	3	12799088
Pubmed	Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes.	RAB23 RAB22A RAB32	3.15e-05	18	120	3	21255211
Pubmed	Interactions between HERC2, OCA2 and MC1R may influence human pigmentation phenotype.	MC1R HERC2	3.53e-05	3	120	2	19208107
Pubmed	Identification of Key Prognostic Biomarker and Its Correlation with Immune Infiltrates in Pancreatic Ductal Adenocarcinoma.	COL6A3 FBN1	3.53e-05	3	120	2	32934754
Pubmed	Nuclear import of Pin1 is mediated by a novel sequence in the PPIase domain.	GRM1 KPNA1	3.53e-05	3	120	2	19084525
Pubmed	CD38-NADase is a new major contributor to Duchenne muscular dystrophic phenotype.	CD38 DMD	3.53e-05	3	120	2	35298089
Pubmed	An atlas of genetic influences on human blood metabolites.	MGAM ABCC4 UGT1A5 UGT1A4 RAB3GAP1 PRODH	5.35e-05	190	120	6	24816252
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	SEH1L ELP1 URB2 GTF3C3 FASN RAB3GAP1 URB1 AAAS ATAD3A SERPINB12 EIF2B5 MMS19 HERC2 CDC20 KPNA1	6.74e-05	1353	120	15	29467282
Pubmed	Genetic variations and haplotypes of UDP-glucuronosyltransferase 1A locus in a Korean population.	UGT1A5 UGT1A4	7.05e-05	4	120	2	18223459
Pubmed	Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle.	RYR1 DMD	7.05e-05	4	120	2	19198614
Pubmed	STIM1 signalling controls store-operated calcium entry required for development and contractile function in skeletal muscle.	RYR1 DMD	7.05e-05	4	120	2	18488020
Pubmed	Retention of stress susceptibility in the mdx mouse model of Duchenne muscular dystrophy after PGC-1α overexpression or ablation of IDO1 or CD38.	CD38 DMD	7.05e-05	4	120	2	38181046
Pubmed	iNOS is not responsible for RyR1 S-nitrosylation in mdx mice with truncated dystrophin.	RYR1 DMD	7.05e-05	4	120	2	32693782
Pubmed	Genetic analysis of three important genes in pigmentation and melanoma susceptibility: CDKN2A, MC1R and HERC2/OCA2.	MC1R HERC2	7.05e-05	4	120	2	20629734
Pubmed	Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity.	RAB23 RAB22A RAB3GAP1 RAB32	1.16e-04	72	120	4	16923123
Pubmed	A Japanese-specific allele in the GALNT11 gene.	ABCC4 FBN1	1.17e-04	5	120	2	20547088
Pubmed	Nitric oxide signalling pathway in Duchenne muscular dystrophy mice: up-regulation of L-arginine transporters.	SLC7A1 DMD	1.17e-04	5	120	2	23009292
Pubmed	Hepatic deficiency in transcriptional cofactor TBL1 promotes liver steatosis and hypertriglyceridemia.	TBL1Y TBL1XR1	1.17e-04	5	120	2	21459324
Pubmed	Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2.	CELA3B CELA3A	1.17e-04	5	120	2	27358403
Pubmed	Model-based prediction of human hair color using DNA variants.	MC1R HERC2	1.17e-04	5	120	2	21197618
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	EPPK1 ARHGAP26 ELP1 MIB2 NEFL SNAP91 HERC2 TNR	1.29e-04	430	120	8	32581705
Pubmed	Reporter Gene Silencing in Targeted Mouse Mutants Is Associated with Promoter CpG Island Methylation.	RAB32 ARAP1	1.75e-04	6	120	2	26275310
Pubmed	CARD6 is a modulator of NF-kappa B activation by Nod1- and Cardiak-mediated pathways.	XK CARD8	1.75e-04	6	120	2	12775719
Pubmed	Structure of the MeCP2-TBLR1 complex reveals a molecular basis for Rett syndrome and related disorders.	TBL1Y TBL1XR1	1.75e-04	6	120	2	28348241
Pubmed	Developmental regulation of biglycan expression in muscle and tendon.	COL6A3 DMD	1.75e-04	6	120	2	16810681
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	SEH1L EPPK1 ORC3 ELP1 NCBP1 FASN CDC20 ARAP1 KPNA1	1.95e-04	582	120	9	20467437
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	GABRB2 COL6A3 RAB22A CUBN AQP1 RYR1 SCRN2 FASN RAB3GAP1 OSBPL1A SCIN DOP1B	2.12e-04	1016	120	12	19056867
Pubmed	A gene expression map of human chromosome 21 orthologues in the mouse.	AIRE NCAM2 URB1 TMEM50B DOP1B	2.27e-04	158	120	5	12466855
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	EPPK1 ELP1 NCBP1 URB2 NEFL FASN URB1 AAAS ATAD3A SERPINB12 HERC2 SCIN	2.28e-04	1024	120	12	24711643
Pubmed	Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37.	UGT1A5 UGT1A4	2.45e-04	7	120	2	8467709
Pubmed	Proteomic analysis of the mammalian nuclear pore complex.	SEH1L AAAS	2.45e-04	7	120	2	12196509
Pubmed	The nuclear receptor corepressor deacetylase activating domain is essential for repression by thyroid hormone receptor.	TBL1Y TBL1XR1	2.45e-04	7	120	2	15695367
Pubmed	Nox4 - RyR1 - Nox2: Regulators of micro-domain signaling in skeletal muscle.	RYR1 DMD	2.45e-04	7	120	2	32506037
Pubmed	Zbtb7c is a molecular 'off' and 'on' switch of Mmp gene transcription.	TBL1Y TBL1XR1	2.45e-04	7	120	2	27646874
Pubmed	Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.	DNAH8 DNAH9	2.45e-04	7	120	2	31178125
Pubmed	Human chromosome 21 gene expression atlas in the mouse.	AIRE NCAM2 URB1 TMEM50B DOP1B	2.63e-04	163	120	5	12466854
Pubmed	Regulatory pathway analysis by high-throughput in situ hybridization.	GABRB2 GRM1 TMEM131L FZD2	2.86e-04	91	120	4	17953485
Pubmed	Candidate gene study to investigate the genetic determinants of normal variation in central corneal thickness.	AQP1 FBN1	3.26e-04	8	120	2	20360993
Pubmed	A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma.	TBL1Y TBL1XR1	3.26e-04	8	120	2	16127449
Pubmed	A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation.	MC1R HERC2	3.26e-04	8	120	2	18483556
Pubmed	Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor.	TBL1Y TBL1XR1	3.26e-04	8	120	2	23770565
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	WDR64 ORC3 ARHGAP26 ELP1 URB2 RYR1 RAB3GAP1 AAAS KPNA1	3.82e-04	638	120	9	31182584
Pubmed	A genome-wide association study identifies UGT1A1 as a regulator of serum cell-free DNA in young adults: The Cardiovascular Risk in Young Finns Study.	UGT1A5 UGT1A4	4.18e-04	9	120	2	22511988
Pubmed	A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini.	UGT1A5 UGT1A4	4.18e-04	9	120	2	1339448
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	ORC3 ELP1 MIB2 TMEM14DP DENND3 FARP2 PWP1 EIF2B5 UGGT2	4.37e-04	650	120	9	38777146
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	EPPK1 ARHGAP26 MIB2 RYR1 ARHGEF10L SLC7A1 FASN URB1 C2CD3 STK40 HERC2 ARAP1	4.51e-04	1105	120	12	35748872
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	ELP1 NCBP1 SLC7A1 FASN ATAD3A EIF2B5 MMS19 HERC2 RAB32	4.72e-04	657	120	9	36180527
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	ARHGEF10 TECPR2 HERC2 DNAH9	4.75e-04	104	120	4	9205841
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	COL6A3 NEFL ATAD3A DMD DNAH8	4.93e-04	187	120	5	26460568
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	DIS3L ZNF343 AIRE NCAM2 NCBP1 NEFL FBN1 ARHGEF10 OSBPL1A ZNF558 HERC2 DOP1B KPNA1	5.07e-04	1285	120	13	35914814
Pubmed	The epigenetic regulators Bmi1 and Ring1B are differentially regulated in pancreatitis and pancreatic ductal adenocarcinoma.	CELA3B CELA3A	5.22e-04	10	120	2	19585519
Pubmed	Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study.	UGT1A5 UGT1A4	5.22e-04	10	120	2	23642732
Pubmed	A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors.	TBL1Y TBL1XR1	5.22e-04	10	120	2	14980219
Pubmed	UDP-glucuronosyltransferases.	UGT1A5 UGT1A4	5.22e-04	10	120	2	11465080
Pubmed	AAV-mediated intramuscular delivery of myotubularin corrects the myotubular myopathy phenotype in targeted murine muscle and suggests a function in plasma membrane homeostasis.	RYR1 DMD	5.22e-04	10	120	2	18434328
Pubmed	A genome-wide association study for serum bilirubin levels and gene-environment interaction in a Chinese population.	UGT1A5 UGT1A4	5.22e-04	10	120	2	23371916
Pubmed	Genetic determinants of hair, eye and skin pigmentation in Europeans.	MC1R HERC2	5.22e-04	10	120	2	17952075
Pubmed	A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia.	UGT1A5 UGT1A4	5.22e-04	10	120	2	22558097
Pubmed	A genome-wide association study of breast and prostate cancer in the NHLBI's Framingham Heart Study.	ABCC4 FBN1	6.36e-04	11	120	2	17903305
Pubmed	FBXO11 constitutes a major negative regulator of MHC class II through ubiquitin-dependent proteasomal degradation of CIITA.	ATAD3A MMS19	6.36e-04	11	120	2	37279268
Pubmed	BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A.	NEFL SLC7A1 RAB3GAP1 EIF2B5 DMD TAF7 TMEM50B	6.49e-04	419	120	7	33001583
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	ORC3 ELP1 TBL1XR1 RAB3GAP1 IGHA1 EIF2B5 MMS19 KPNA1	7.47e-04	560	120	8	35241646
Pubmed	Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia.	UGT1A5 UGT1A4	7.62e-04	12	120	2	19419973
Pubmed	Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus.	UGT1A5 UGT1A4	7.62e-04	12	120	2	11434514
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	EPPK1 ELP1 URB2 TBL1XR1 FASN RAB3GAP1 AAAS DNAH8 KPNA1	7.72e-04	704	120	9	29955894
Pubmed	Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo.	CUBN TRIM6 GTF3C3 PWP1 RAB3GAP1 FZD2 EPHA1	7.76e-04	432	120	7	7671812
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	NCBP1 GTF3C3 FARP2 MMS19 HERC2 DMD	7.84e-04	313	120	6	38270169
Pubmed	The TIP60 Complex Is a Conserved Coactivator of HIF1A.	ELP1 FASN ATAD3A MMS19	8.13e-04	120	120	4	27320910
Pubmed	UGT1A1 is a major locus influencing bilirubin levels in African Americans.	UGT1A5 UGT1A4	8.98e-04	13	120	2	22085899
Pubmed	Genome-wide analysis of hepatic lipid content in extreme obesity.	UGT1A5 UGT1A4	8.98e-04	13	120	2	25246029
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	CARD8 RYR1 FASN EML1 DOP1B	9.04e-04	214	120	5	22199357
Pubmed	Human metabolic individuality in biomedical and pharmaceutical research.	UGT1A5 UGT1A4 PRODH	1.02e-03	57	120	3	21886157
Pubmed	CEMIP, acting as a scaffold protein for bridging GRAF1 and MIB1, promotes colorectal cancer metastasis via activating CDC42/MAPK pathway.	ARHGAP26 IGHA1 ATAD3A	1.02e-03	57	120	3	36849460
Pubmed	GRWD1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system.	ELP1 GTF3C3 FASN URB1 ATAD3A	1.04e-03	221	120	5	29991511
Pubmed	Mayo Genome Consortia: a genotype-phenotype resource for genome-wide association studies with an application to the analysis of circulating bilirubin levels.	UGT1A5 UGT1A4	1.05e-03	14	120	2	21646302
Pubmed	Human UDP-glucuronosyltransferases: metabolism, expression, and disease.	UGT1A5 UGT1A4	1.05e-03	14	120	2	10836148
Pubmed	The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence.	UGT1A5 UGT1A4	1.05e-03	14	120	2	9295054
Pubmed	Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation.	UGT1A5 UGT1A4	1.05e-03	14	120	2	14672974
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	SEH1L NCBP1 URB2 PWP1 URB1 AAAS	1.06e-03	332	120	6	25693804
Pubmed	LC-MS/MS Based Quantitation of ABC and SLC Transporter Proteins in Plasma Membranes of Cultured Primary Human Retinal Pigment Epithelium Cells and Immortalized ARPE19 Cell Line.	ABCC4 SLC7A1	1.20e-03	15	120	2	28112518
Pubmed	Dynamic expression of chymotrypsin-like elastase 1 over the course of murine lung development.	CELA3B CELA3A	1.20e-03	15	120	2	24793170
Pubmed	Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans.	MC1R HERC2	1.20e-03	15	120	2	23548203
Pubmed	FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.	RAB23 ANKRD46 RAB3GAP1 AAAS ATAD3A TMEM131L UGGT2	1.23e-03	468	120	7	31056421
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	SEH1L EPPK1 CARD8 FASN SHPRH EML1 DMD VSIG10L2 KPNA1	1.24e-03	754	120	9	35906200
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	EPPK1 ARHGAP26 NCAM2 ARHGEF10L FARP2 NEFL ARHGEF10 DMD FGD6 ARAP1	1.31e-03	916	120	10	32203420
Pubmed	Hereditary Spastic Paraplegia Overview	SPG11 TECPR2 ATAD3A	1.37e-03	63	120	3	20301682
Cytoband	2q37	COL6A3 UGT1A5 UGT1A4	7.42e-05	31	120	3	2q37
Cytoband	6q24.3	SHPRH RAB32	3.67e-04	11	120	2	6q24.3
GeneFamily	WD repeat domain containing	SEH1L WDR64 TBL1Y TBL1XR1 DENND3 PWP1 AAAS EML1 CDC20 WDFY1	3.70e-07	262	84	10	362
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	MIB2 HERC2 DMD	7.51e-05	18	84	3	91
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ARHGEF10L FARP2 ARHGEF10 FGD6	2.51e-04	66	84	4	722
GeneFamily	Sterile alpha motif domain containing	SFMBT1 ARAP1 EPHA1 L3MBTL4	7.51e-04	88	84	4	760
GeneFamily	Sterile alpha motif domain containing\|MBT domain containing	SFMBT1 L3MBTL4	7.52e-04	9	84	2	1263
GeneFamily	Dyneins, axonemal	DNAH8 DNAH9	2.77e-03	17	84	2	536
GeneFamily	RAB, member RAS oncogene GTPases	RAB23 RAB22A RAB32	3.43e-03	65	84	3	388
GeneFamily	Ankyrin repeat domain containing	MIB2 ANKRD46 ANKRD33 OSBPL1A ARAP1	5.40e-03	242	84	5	403
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GABRB2 MGAM NCAM2 PKD1L2 GRM1 DMD DNAH9	6.50e-07	184	119	7	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GABRB2 MGAM NCAM2 PKD1L2 GRM1 DMD DNAH9	6.50e-07	184	119	7	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GABRB2 MGAM NCAM2 PKD1L2 GRM1 DMD DNAH9	6.50e-07	184	119	7	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW19-Macroglial-Astrocyte\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	ABCC4 NCAM2 RFTN2 ARHGEF10 TECPR2 OSBPL1A PRODH	1.06e-06	198	119	7	bfad1c51cf884ff7ce89f8278820800582541dc7
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW19-Macroglial\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	ABCC4 NCAM2 RFTN2 ARHGEF10 TECPR2 OSBPL1A PRODH	1.06e-06	198	119	7	6372e65242236c497d9b3be147092897c1609d22
ToppCell	368C-Lymphocytic-ILC-ILC-2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ARHGAP26 URB2 CUBN VSIG10L EPHA1 DOP1B	9.00e-06	180	119	6	eb5a57604c7f2ad256c300085dbf5069d0ae1ad0
ToppCell	368C-Lymphocytic-ILC\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ARHGAP26 URB2 CUBN VSIG10L EPHA1 DOP1B	9.00e-06	180	119	6	ddba4dc3bbcfe4e4a22400be73bbc62d3ff27d3c
ToppCell	ASK454-Epithelial-Secretory\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	ELP1 NCBP1 URB1 AAAS ARHGEF10 DOP1B	1.26e-05	191	119	6	c63c781e7e93265e591cf494cb4ce8ed797c24fb
Disease	1,5 anhydroglucitol measurement	MGAM NCAM2 PKD1L2 RAB3GAP1	5.16e-06	29	117	4	EFO_0008009
Disease	sensory system disease (implicated_via_orthology)	TBL1Y TBL1XR1	4.66e-05	3	117	2	DOID:0050155 (implicated_via_orthology)
Disease	scoliosis (is_implicated_in)	ELP1 FBN1	9.30e-05	4	117	2	DOID:0060249 (is_implicated_in)
Disease	hormone measurement	UGT1A5 NAALADL2 UGT1A4 ZNF716	3.55e-04	84	117	4	EFO_0004730
Disease	metabolite measurement	ABCC4 UGT1A5 NCBP1 PKD1L2 SLC22A24 UGT1A4 DMD SPRYD4 PRODH	4.03e-04	560	117	9	EFO_0004725
Disease	X-11793--oxidized bilirubin measurement	UGT1A5 UGT1A4	4.30e-04	8	117	2	EFO_0021260
Disease	Succinimide measurement	UGT1A5 UGT1A4	4.30e-04	8	117	2	EFO_0022118
Disease	X-11530 measurement	UGT1A5 UGT1A4	4.30e-04	8	117	2	EFO_0021249
Disease	sulfate of piperine metabolite C16H19NO3 (2) measurement	UGT1A5 UGT1A4	4.30e-04	8	117	2	EFO_0801034
Disease	cholelithiasis, bilirubin measurement	UGT1A5 UGT1A4	4.30e-04	8	117	2	EFO_0004570, EFO_0004799
Disease	X-11522 measurement	UGT1A5 UGT1A4	4.30e-04	8	117	2	EFO_0800696
Disease	X-10458 measurement	UGT1A5 UGT1A4	4.30e-04	8	117	2	EFO_0800692
Disease	X-24849 measurement	UGT1A5 UGT1A4	4.30e-04	8	117	2	EFO_0800909
Disease	membrane-associated progesterone receptor component 1 measurement	UGT1A5 UGT1A4	4.30e-04	8	117	2	EFO_0802740
Disease	X-16946 measurement	UGT1A5 UGT1A4	4.30e-04	8	117	2	EFO_0800766
Disease	X-11442 measurement	UGT1A5 UGT1A4	5.51e-04	9	117	2	EFO_0021236
Disease	X-11441 measurement	UGT1A5 UGT1A4	5.51e-04	9	117	2	EFO_0021235
Disease	circulating cell free DNA measurement	UGT1A5 UGT1A4	5.51e-04	9	117	2	EFO_0004739
Disease	sulfate of piperine metabolite C18H21NO3 (3) measurement	UGT1A5 UGT1A4	5.51e-04	9	117	2	EFO_0801037
Disease	sulfate of piperine metabolite C18H21NO3 (1) measurement	UGT1A5 UGT1A4	5.51e-04	9	117	2	EFO_0801036
Disease	X-11880 measurement	UGT1A5 UGT1A4	5.51e-04	9	117	2	EFO_0800698
Disease	protein-tyrosine kinase 6 measurement	UGT1A5 UGT1A4	5.51e-04	9	117	2	EFO_0020691
Disease	testis-specific chromodomain protein Y 1 measurement	UGT1A5 UGT1A4	5.51e-04	9	117	2	EFO_0802127
Disease	bilirubin measurement, response to xenobiotic stimulus	UGT1A5 UGT1A4	5.51e-04	9	117	2	EFO_0004570, GO_0009410
Disease	bilirubin measurement, response to tenofovir	UGT1A5 UGT1A4	6.87e-04	10	117	2	EFO_0004570, EFO_0009279
Disease	X-21448 measurement	UGT1A5 UGT1A4	6.87e-04	10	117	2	EFO_0800816
Disease	UDP-glucuronosyltransferase 1-6 measurement	UGT1A5 UGT1A4	6.87e-04	10	117	2	EFO_0802185
Disease	X-23974 measurement	UGT1A5 UGT1A4	6.87e-04	10	117	2	EFO_0800867
Disease	executive function measurement	SFMBT1 COL6A3 CPXM2 PAK6 CARD8 RYR1 ARHGEF10L	7.71e-04	376	117	7	EFO_0009332
Disease	pigmentation disease (is_implicated_in)	MC1R HERC2	8.38e-04	11	117	2	DOID:10123 (is_implicated_in)
Disease	pregnenetriol sulfate measurement	UGT1A5 UGT1A4	8.38e-04	11	117	2	EFO_0800586
Disease	plasma N-desmethylclozapine measurement	UGT1A5 UGT1A4	8.38e-04	11	117	2	EFO_0600039
Disease	histidine betaine (hercynine) measurement	UGT1A5 UGT1A4	8.38e-04	11	117	2	EFO_0800972
Disease	X-21796 measurement	UGT1A5 UGT1A4	8.38e-04	11	117	2	EFO_0800825
Disease	insomnia, bilirubin measurement	UGT1A5 UGT1A4	8.38e-04	11	117	2	EFO_0004570, EFO_0004698
Disease	aldosterone measurement	UGT1A5 UGT1A4	8.38e-04	11	117	2	EFO_0010219
Disease	Gastrointestinal Stromal Sarcoma	RAB23 C2CD3 DMD	8.68e-04	47	117	3	C3179349
Disease	niacinamide measurement	NAALADL2 OSBPL1A	1.00e-03	12	117	2	EFO_0010511
Disease	hair colour measurement, hair morphology measurement	MC1R HERC2	1.00e-03	12	117	2	EFO_0007821, EFO_0007822
Disease	p-cresol glucuronide measurement	UGT1A5 UGT1A4	1.00e-03	12	117	2	EFO_0800079
Disease	biliverdin measurement	UGT1A5 UGT1A4	1.00e-03	12	117	2	EFO_0021033
Disease	Gastrointestinal Stromal Tumors	RAB23 C2CD3 DMD	1.04e-03	50	117	3	C0238198
Disease	pregnenetriol disulfate measurement	UGT1A5 UGT1A4	1.18e-03	13	117	2	EFO_0800587
Disease	retinol dehydrogenase 16 measurement	UGT1A5 UGT1A4	1.18e-03	13	117	2	EFO_0802007
Disease	dystonia (is_implicated_in)	MECR TMEM151A	1.38e-03	14	117	2	DOID:543 (is_implicated_in)
Disease	low density lipoprotein cholesterol measurement, body fat percentage	UGT1A5 UGT1A4	2.04e-03	17	117	2	EFO_0004611, EFO_0007800
Disease	X-21441 measurement	UGT1A5 UGT1A4	2.04e-03	17	117	2	EFO_0800814
Disease	angiopoietin-related protein 1 measurement	UGT1A5 UGT1A4	2.29e-03	18	117	2	EFO_0801382
Disease	skin sensitivity to sun	MC1R HERC2	2.55e-03	19	117	2	EFO_0004795
Disease	tissue factor measurement	UGT1A5 UGT1A4	3.12e-03	21	117	2	EFO_0010623
Disease	FEV/FEC ratio	MGAM COL6A3 ARHGAP26 ACVR1B DENND3 FBN1 UGGT2 HHIPL1 TAF7 FGD6 HCRTR1 ARAP1	3.53e-03	1228	117	12	EFO_0004713

Protein segments in the cluster

Peptide	Gene	Start	Entry
LASAWIDAEVTEFRT	URB2	431	Q14146
EAIAHRIFTTASDVW	EPHA1	796	P21709
DAAIRVWDVSTETCV	AAAS	266	Q9NRG9
FQIALASRVSEWDSV	ARHGEF10	481	O15013
FQIALSSRVAEWDST	ARHGEF10L	376	Q9HCE6
ATVASAAADETLRLW	CDC20	456	Q12834
VAVKIFSSREERSWF	ACVR1B	231	P36896
RAFVTDWDKVTATVA	ATAD3A	286	Q9NVI7
WRAVVAEFLATTLFV	AQP1	11	P29972
HVADFRWRVDVAIST	COMMD5	151	Q9GZQ3
DTLFERATNSSWVVV	SNAP91	61	O60641
FLAWLTEAETTANVL	DMD	2701	P11532
LSSFRTTWQEFVEDL	ANKRD46	176	Q86W74
LTEQRIVFFSSDWAL	DENND3	211	A2RUS2
LLTQDSTAILDFWRV	AIRE	66	O43918
SVFWKTVSRRFAEAA	CD38	186	P28907
WFLSENATVAAETRA	CPXM2	486	Q8N436
SFEAVSSWREKVVAE	RAB23	96	Q9ULC3
VGKSSIVWRFVEDSF	RAB22A	16	Q9UL26
DFTTASEWERFISKV	RAB3GAP1	16	Q15042
TALEWAVLTDSFDTV	ANKRD33	226	Q7Z3H0
AVLTDSFDTVWRIRQ	ANKRD33	231	Q7Z3H0
FDISRSSTFEAVLKW	RAB32	106	Q13637
VISTLDADWLELTTF	RFTN2	276	Q52LD8
AALEAFSRKEWAAVT	IQCF1	116	Q8N6M8
ARRAVAAIWVASVVF	MC1R	161	Q01726
EVISRSLYATEVDIW	PAK6	571	Q9NQU5
SELSRDFTRLFVWEI	NCBP1	626	Q09161
SSEWIRISEFRVSED	HHIPL1	276	Q96JK4
VSWLIRATLSESENF	NAAA	216	Q02083
VSSVWLEVVERATRF	HERC2	246	O95714
LWASIRREVFQTASE	MMS19	301	Q96T76
VVWFILVHVTDRSDA	APH1A	51	Q96BI3
LSQFTTVDREAIWAE	DOP1B	1056	Q9Y3R5
VSWDVAFVNISRTVL	MGAM	2491	O43451
LAEETILSWFSQRDT	EIF2B5	676	Q13144
LITTEASDDSFRVWI	DNAH8	3981	Q96JB1
FSQEETRFARLWILT	FZD2	236	Q14332
ARWTVDEVAEFVQSL	L3MBTL4	541	Q8NA19
LTDVNAIDRWSRIFF	GABRB2	481	P47870
LTWIEEDVFLAVSHS	ELP1	506	O95163
VTWKETVDFLVSLAV	OR6Q1	196	Q8NGQ2
WDERAIKATFDISLV	NPEPPSL1	191	A6NEC2
VAAFAVSAVASQWER	OSBPL1A	606	Q9BXW6
TWLDALTRAVFVEST	PKD1L2	2126	Q7Z442
FLTTSRWFAVRLDAI	ABCC4	941	O15439
SVAVLTLSFIALDRW	HCRTR1	131	O43613
TNSVWIRFKIDASVE	CUBN	791	O60494
LFSTEEVTRSVIAWG	C2CD3	836	Q4AC94
VSLASWDVEKTAIFA	FBN1	2751	P35555
TVFTRVSAFIDWIEE	CELA3A	251	P09093
TTWFSADERATATAI	SLC49A4	171	Q96SL1
RVVVRIDSWESTSVY	DIS3L	391	Q8TF46
AAADIIFLVDSSWTI	COL6A3	36	P12111
FAITEATLSAWSSLD	FAM131C	156	Q96AQ9
TFAVTSILRVAAEDW	IGHA1	291	P01876
VRDEVTVTIAFGSWS	CARD8	201	Q9Y2G2
TVFTRVSAFIDWIEE	CELA3B	251	P08861
GTWRTEAVFSEEALI	MECR	136	Q9BV79
GRWFVFDTETKDLVT	EML1	606	O00423
KLSTVDAVISIWFEV	DNAH9	1501	Q9NYC9
FSSVECVKSTWDLIR	DNAH9	2691	Q9NYC9
LEWSNIESIIAIAFS	GRM1	586	Q13255
VITVWFRSAVVKEDA	FARP2	556	O94887
ILSQDAWESLFSRVS	FASN	1371	P49327
SCSFDRTAAVWEEIV	SEH1L	76	Q96EE3
REAATAVAALLWAAV	RYR1	4326	P21817
LFDREIVVTISWAKS	ESRRA	231	P11474
WADRTARVICDTFTV	LGSN	161	Q5TDP6
SFLDEEVSTAWKVLR	PARP6	76	Q2NL67
DVETGRSVASVTWAD	MIB2	191	Q96AX9
RLINLVDWSEAFATV	ORC3	641	Q9UBD5
VDWSEAFATVVTAAE	ORC3	646	Q9UBD5
VETFRHRAISDTWLT	ICA1	141	Q05084
STDAEAVSTRWEIIA	TAF7	171	Q15545
AADVLEALSAIIASW	STK40	321	Q8N2I9
SDWSDVEEISTVRFS	TATDN2	331	Q93075
FREWAVVLADTAVTS	SPRYD4	71	Q8WW59
IVFTPDFTSSWVIRD	TMEM131L	816	A2VDJ0
DFTSSWVIRDLSLVT	TMEM131L	821	A2VDJ0
SFLSTIVTEWDLVCE	SLC22A24	126	Q8N4F4
RVVRATEVPLSWDSF	SCIN	146	Q9Y6U3
FLLADRTEAWVLETA	SCRN2	161	Q96FV2
TAEFRTRKEAAWAIT	KPNA1	391	P52294
WELLFSEAISSEQRA	EPPK1	511	P58107
VWFSVAAVVLSLARS	ARHGAP26	706	Q9UNA1
IASRAEIEDWFTAET	PRODH	291	O43272
ATESALHFLWREIVT	SHPRH	326	Q149N8
SRVATVDFTELEWHI	TMEM151A	336	Q8N4L1
TWEVIRSAAVKLTDA	MROH2B	1516	Q7Z745
AASLAVSWVLRSVAE	URB1	2096	O60287
VVSERSLRSWVEFNA	SERPINB12	366	Q96P63
ASASFDSTVRLWDVD	TBL1XR1	416	Q9BZK7
VSESWALFVDLSVRS	SLC36A3	361	Q495N2
AIFAVLTSVLTKDDW	GTF3C3	611	Q9Y5Q9
ALSTSEVAERIWAAA	ARAP1	531	Q96P48
SVTGFTALFTWEVER	SPG11	431	Q96JI7
RVWDISTVSSVNEAF	PWP1	456	Q13610
DVTVIFTEAEWKRLS	ZNF343	66	Q6P1L6
LTFRDIAIEFSLAEW	ZNF735	16	P0CB33
EITWKRAVDGFTFTE	NCAM2	331	O15394
SSVARAWSATFDELI	SLC7A1	126	P30825
TSWLRGLVTFEDVAV	ZNF558	36	Q96NG5
FILSASSATERDEWL	FGD6	1161	Q6ZV73
LVRDVSDTVAFVEWI	TNR	511	Q92752
VAAWFFATLAAVAES	TMEM102	266	Q8N9M5
RNVWDFLAATSVTFV	TMEM14DP	61	A8MWL7
IDWSERRNAVASVVA	TMEM50B	16	P56557
LTFRDIAIEFSLAEW	ZNF716	16	A6NP11
REVSVVDLVSHASVW	UGT1A5	241	P35504
FVALSDDTAWIIRTS	TECPR2	896	O15040
ILTRTEGFEDVVTTW	NME9	231	Q86XW9
ASASFDSTVRLWDVE	TBL1Y	426	Q9BQ87
WEEADAVIVSARLVS	TLCD3B	31	Q71RH2
WSVADVVRFIRSTDC	SFMBT1	796	Q9UHJ3
VLTWDVERGALISSF	VSIG10L	686	Q86VR7
SIISAVTLWIIADFD	UGGT2	736	Q9NYU1
FWASEREEVTLSCLA	VSIG10L2	256	P0DP72
RVSAIIFSLATEWVI	WDFY1	116	Q8IWB7
IFLWRSFEIATRVVV	XK	211	P51811
DVSDVTERSEFWTLR	TRIM6	251	Q9C030
VVSLSSAKVFRVWDI	WDR64	381	B1ANS9
REVSVVDLVSYASVW	UGT1A4	241	P22310
QEWASSTAIITAFIR	NAALADL2	461	Q58DX5
AEEWFKSRFTVLTES	NEFL	276	P07196