Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
HumanPheno	Short REM sleep	FLII RAI1	1.16e-04	4	23	2	HP:5200360
HumanPheno	Abnormal sleep architecture	FLII RAI1	1.16e-04	4	23	2	HP:5200298
HumanPheno	Onychotillomania	FLII RAI1	1.16e-04	4	23	2	HP:0032509
HumanPheno	Vocal cord polyp	FLII RAI1	1.16e-04	4	23	2	HP:0032041
Domain	EGF_CA	MASP1 SCUBE1 FBLN2 SCUBE2 UMODL1 MASP2	6.37e-07	86	67	6	PF07645
Domain	EGF_Ca-bd_CS	MASP1 SCUBE1 FBLN2 SCUBE2 UMODL1 MASP2	1.30e-06	97	67	6	IPR018097
Domain	EGF_CA	MASP1 SCUBE1 FBLN2 SCUBE2 UMODL1 MASP2	1.46e-06	99	67	6	PS01187
Domain	ASX_HYDROXYL	MASP1 SCUBE1 FBLN2 SCUBE2 UMODL1 MASP2	1.55e-06	100	67	6	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	MASP1 SCUBE1 FBLN2 SCUBE2 UMODL1 MASP2	2.18e-06	106	67	6	IPR000152
Domain	EGF-like_dom	MASP1 SCUBE1 FBLN2 MALRD1 SCUBE2 UMODL1 LAMA5 MASP2	2.95e-06	249	67	8	IPR000742
Domain	EGF_1	MASP1 SCUBE1 FBLN2 MALRD1 SCUBE2 UMODL1 LAMA5 MASP2	3.52e-06	255	67	8	PS00022
Domain	EGF-like_CS	MASP1 SCUBE1 FBLN2 MALRD1 SCUBE2 UMODL1 LAMA5 MASP2	4.18e-06	261	67	8	IPR013032
Domain	EGF_2	MASP1 SCUBE1 FBLN2 MALRD1 SCUBE2 UMODL1 LAMA5 MASP2	4.68e-06	265	67	8	PS01186
Domain	EGF_CA	MASP1 SCUBE1 FBLN2 SCUBE2 UMODL1 MASP2	4.95e-06	122	67	6	SM00179
Domain	EGF-like_Ca-bd_dom	MASP1 SCUBE1 FBLN2 SCUBE2 UMODL1 MASP2	5.44e-06	124	67	6	IPR001881
Domain	Keratin_B2	KRTAP4-7 KRTAP4-11 KRTAP4-6 KRTAP4-9	1.25e-05	40	67	4	PF01500
Domain	EGF_3	MASP1 SCUBE1 FBLN2 MALRD1 SCUBE2 UMODL1 MASP2	2.09e-05	235	67	7	PS50026
Domain	EGF	SCUBE1 FBLN2 MALRD1 SCUBE2 UMODL1 LAMA5 MASP2	2.09e-05	235	67	7	SM00181
Domain	CUB	MASP1 SCUBE1 SCUBE2 MASP2	2.84e-05	49	67	4	PF00431
Domain	CUB	MASP1 SCUBE1 SCUBE2 MASP2	3.08e-05	50	67	4	SM00042
Domain	-	MASP1 SCUBE1 SCUBE2 MASP2	3.60e-05	52	67	4	2.60.120.290
Domain	CUB	MASP1 SCUBE1 SCUBE2 MASP2	3.88e-05	53	67	4	PS01180
Domain	CUB_dom	MASP1 SCUBE1 SCUBE2 MASP2	5.18e-05	57	67	4	IPR000859
Domain	KAP	KRTAP4-7 KRTAP4-11 KRTAP4-6 KRTAP4-9	5.55e-05	58	67	4	IPR002494
Domain	G8	PKHD1 PKHD1L1	7.57e-05	4	67	2	PF10162
Domain	G8_domain	PKHD1 PKHD1L1	7.57e-05	4	67	2	IPR019316
Domain	G8	PKHD1 PKHD1L1	7.57e-05	4	67	2	PS51484
Domain	Pept_S1A_C1r/C1S/mannan-bd	MASP1 MASP2	7.57e-05	4	67	2	IPR024175
Domain	G8	PKHD1 PKHD1L1	7.57e-05	4	67	2	SM01225
Domain	cEGF	SCUBE1 FBLN2 SCUBE2	1.08e-04	26	67	3	IPR026823
Domain	cEGF	SCUBE1 FBLN2 SCUBE2	1.08e-04	26	67	3	PF12662
Domain	PbH1	PKHD1 PKHD1L1	1.88e-04	6	67	2	SM00710
Domain	PbH1	PKHD1 PKHD1L1	1.88e-04	6	67	2	IPR006626
Domain	Growth_fac_rcpt_	SCUBE1 FBLN2 SCUBE2 UMODL1 LAMA5	2.43e-04	156	67	5	IPR009030
Domain	TRYPSIN_SER	MASP1 TMPRSS13 CELA2A MASP2	3.06e-04	90	67	4	IPR033116
Domain	Pectin_lyase_fold/virulence	PKHD1 PKHD1L1	3.50e-04	8	67	2	IPR011050
Domain	TRYPSIN_HIS	MASP1 TMPRSS13 CELA2A MASP2	5.12e-04	103	67	4	IPR018114
Domain	TRYPSIN_SER	MASP1 TMPRSS13 CELA2A MASP2	5.71e-04	106	67	4	PS00135
Domain	TRYPSIN_HIS	MASP1 TMPRSS13 CELA2A MASP2	5.91e-04	107	67	4	PS00134
Domain	Ephrin_rec_like	SCUBE1 SCUBE2	6.83e-04	11	67	2	PF07699
Domain	Peptidase_S1A	MASP1 TMPRSS13 CELA2A MASP2	7.26e-04	113	67	4	IPR001314
Domain	TRYPSIN_DOM	MASP1 TMPRSS13 CELA2A MASP2	7.75e-04	115	67	4	PS50240
Domain	EGF_3	SCUBE1 SCUBE2	8.18e-04	12	67	2	PF12947
Domain	EGF_dom	SCUBE1 SCUBE2	8.18e-04	12	67	2	IPR024731
Domain	Tryp_SPc	MASP1 TMPRSS13 CELA2A MASP2	8.27e-04	117	67	4	SM00020
Domain	Trypsin	MASP1 TMPRSS13 CELA2A MASP2	9.38e-04	121	67	4	PF00089
Domain	Trypsin_dom	MASP1 TMPRSS13 CELA2A MASP2	9.38e-04	121	67	4	IPR001254
Domain	Peptidase_S1_PA	MASP1 TMPRSS13 CELA2A MASP2	9.97e-04	123	67	4	IPR009003
Domain	ZP_1	ZP1 UMODL1	1.12e-03	14	67	2	PS00682
Domain	ZP_2	ZP1 UMODL1	1.12e-03	14	67	2	PS51034
Domain	ZP	ZP1 UMODL1	1.29e-03	15	67	2	SM00241
Domain	ZP_dom	ZP1 UMODL1	1.67e-03	17	67	2	IPR001507
Domain	Zona_pellucida	ZP1 UMODL1	1.67e-03	17	67	2	PF00100
Domain	-	ZNF672 ZBTB39 ZBTB20 ZSCAN10 ZNF532 ZNF75A ZNF700 ZXDA	2.88e-03	679	67	8	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZNF672 ZBTB39 ZBTB20 ZSCAN10 ZNF532 ZNF75A ZNF700 ZXDA	3.29e-03	694	67	8	IPR013087
Domain	Ephrin_rec_like	SCUBE1 SCUBE2	3.61e-03	25	67	2	SM01411
Domain	SR	TMPRSS13 CD163	3.61e-03	25	67	2	SM00202
Domain	-	TMPRSS13 CD163	3.61e-03	25	67	2	3.10.250.10
Domain	Tyr-kin_ephrin_A/B_rcpt-like	SCUBE1 SCUBE2	3.61e-03	25	67	2	IPR011641
Domain	SRCR_1	TMPRSS13 CD163	3.90e-03	26	67	2	PS00420
Domain	SRCR_2	TMPRSS13 CD163	3.90e-03	26	67	2	PS50287
Domain	SRCR-like_dom	TMPRSS13 CD163	3.90e-03	26	67	2	IPR017448
Domain	IPT	PKHD1 PKHD1L1	4.20e-03	27	67	2	SM00429
Domain	SRCR	TMPRSS13 CD163	4.20e-03	27	67	2	IPR001190
Domain	zf-C2H2_6	ZNF672 ZSCAN10 ZNF532 ZNF75A ZNF700	5.37e-03	314	67	5	PF13912
Domain	TIG	PKHD1 PKHD1L1	5.51e-03	31	67	2	PF01833
Domain	IPT	PKHD1 PKHD1L1	5.87e-03	32	67	2	IPR002909
Domain	ZINC_FINGER_C2H2_2	ZNF672 ZBTB39 ZBTB20 ZSCAN10 ZNF532 ZNF75A ZNF700 ZXDA	6.36e-03	775	67	8	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF672 ZBTB39 ZBTB20 ZSCAN10 ZNF532 ZNF75A ZNF700 ZXDA	6.46e-03	777	67	8	PS00028
Pathway	WP_COMPLEMENT_ACTIVATION	MASP1 CFP MASP2	6.17e-05	22	50	3	M39502
Pathway	REACTOME_FICOLINS_BIND_TO_REPETITIVE_CARBOHYDRATE_STRUCTURES_ON_THE_TARGET_CELL_SURFACE	MASP1 MASP2	1.22e-04	5	50	2	M27204
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_FIBRINOLYTIC_SYSTEM_C1INH	MASP1 MASP2	1.83e-04	6	50	2	M47882
Pathway	REACTOME_LECTIN_PATHWAY_OF_COMPLEMENT_ACTIVATION	MASP1 MASP2	2.56e-04	7	50	2	MM14654
Pathway	REACTOME_LECTIN_PATHWAY_OF_COMPLEMENT_ACTIVATION	MASP1 MASP2	3.41e-04	8	50	2	M27005
Pathway	WP_COMPLEMENT_SYSTEM	MASP1 LAMA5 CFP MASP2	3.66e-04	96	50	4	M39581
Pubmed	Size polymorphisms in the human ultrahigh sulfur hair keratin-associated protein 4, KAP4, gene family.	KRTAP4-7 KRTAP4-11 KRTAP4-6	4.34e-07	8	70	3	15955084
Pubmed	Characterization of a cluster of human high/ultrahigh sulfur keratin-associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21.	KRTAP4-7 KRTAP4-11 KRTAP4-6 KRTAP4-9	9.45e-07	37	70	4	11279113
Pubmed	Mannose-binding lectin (MBL)-associated serine protease (MASP)-1 contributes to activation of the lectin complement pathway.	MASP1 MASP2	3.99e-06	2	70	2	18424734
Pubmed	Selective inhibition of the lectin pathway of complement with phage display selected peptides against mannose-binding lectin-associated serine protease (MASP)-1 and -2: significant contribution of MASP-1 to lectin pathway activation.	MASP1 MASP2	3.99e-06	2	70	2	20817870
Pubmed	Cutting Edge: Role of MASP-3 in the Physiological Activation of Factor D of the Alternative Complement Pathway.	MASP1 MASP2	3.99e-06	2	70	2	31399515
Pubmed	Dissociation and re-association studies on the interaction domains of mannan-binding lectin (MBL)-associated serine proteases, MASP-1 and MASP-2, provide evidence for heterodimer formation.	MASP1 MASP2	3.99e-06	2	70	2	24424083
Pubmed	Serine proteases of the complement lectin pathway and their genetic variations in ischaemic stroke.	MASP1 MASP2	3.99e-06	2	70	2	28720568
Pubmed	MBL-associated serine proteases (MASPs) and infectious diseases.	MASP1 MASP2	3.99e-06	2	70	2	25862418
Pubmed	Plasma levels of mannan-binding lectin-associated serine proteases MASP-1 and MASP-2 are elevated in type 1 diabetes and correlate with glycaemic control.	MASP1 MASP2	3.99e-06	2	70	2	25533914
Pubmed	The role of MASP-1/3 in complement activation.	MASP1 MASP2	3.99e-06	2	70	2	23402018
Pubmed	Molecular characterization of a novel serine protease involved in activation of the complement system by mannose-binding protein.	MASP1 MASP2	3.99e-06	2	70	2	8018603
Pubmed	The lectin complement pathway serine proteases (MASPs) represent a possible crossroad between the coagulation and complement systems in thromboinflammation.	MASP1 MASP2	3.99e-06	2	70	2	26614707
Pubmed	Monospecific inhibitors show that both mannan-binding lectin-associated serine protease-1 (MASP-1) and -2 Are essential for lectin pathway activation and reveal structural plasticity of MASP-2.	MASP1 MASP2	3.99e-06	2	70	2	22511776
Pubmed	The role of mannose-binding lectin-associated serine protease-3 in activation of the alternative complement pathway.	MASP1 MASP2	3.99e-06	2	70	2	21865552
Pubmed	Cooperation between MASP-1 and MASP-2 in the generation of C3 convertase through the MBL pathway.	MASP1 MASP2	3.99e-06	2	70	2	17182967
Pubmed	Synergy of protease-binding sites within the ecotin homodimer is crucial for inhibition of MASP enzymes and for blocking lectin pathway activation.	MASP1 MASP2	3.99e-06	2	70	2	35483450
Pubmed	Distinct Longitudinal Associations of MBL, MASP-1, MASP-2, MASP-3, and MAp44 With Endothelial Dysfunction and Intima-Media Thickness: The Cohort on Diabetes and Atherosclerosis Maastricht (CODAM) Study.	MASP1 MASP2	3.99e-06	2	70	2	27055907
Pubmed	Distinct pathways of mannan-binding lectin (MBL)- and C1-complex autoactivation revealed by reconstitution of MBL with recombinant MBL-associated serine protease-2.	MASP1 MASP2	1.20e-05	3	70	2	10925294
Pubmed	Rare Variants in LAMA5 Gene associated with FLT4 and FOXC2 Mutations in Primary Lymphedema May Contribute to Severity.	FLT4 LAMA5	1.20e-05	3	70	2	29908552
Pubmed	Two lineages of mannose-binding lectin-associated serine protease (MASP) in vertebrates.	MASP1 MASP2	1.20e-05	3	70	2	9794427
Pubmed	The mannan-binding lectin pathway of complement activation: biology and disease association.	MASP1 MASP2	1.20e-05	3	70	2	11532276
Pubmed	Mannan-binding lectin-associated serine protease (MASP)-1 is crucial for lectin pathway activation in human serum, whereas neither MASP-1 nor MASP-3 is required for alternative pathway function.	MASP1 MASP2	1.20e-05	3	70	2	22966085
Pubmed	Collectin-11/MASP complex formation triggers activation of the lectin complement pathway--the fifth lectin pathway initiation complex.	MASP1 MASP2	1.20e-05	3	70	2	23220946
Pubmed	Revised mechanism of complement lectin-pathway activation revealing the role of serine protease MASP-1 as the exclusive activator of MASP-2.	MASP1 MASP2	1.20e-05	3	70	2	22691502
Pubmed	Mannose-binding lectin binds to a range of clinically relevant microorganisms and promotes complement deposition.	MASP1 MASP2	1.20e-05	3	70	2	10639434
Pubmed	Extra-hepatic transcription of the human mannose-binding lectin gene (mbl2) and the MBL-associated serine protease 1-3 genes.	MASP1 MASP2	1.20e-05	3	70	2	16112196
Pubmed	Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino acid sequences.	FBLN2 LAMA5	1.20e-05	3	70	2	9006922
Pubmed	The relationship of serum SCUBE-1, -2 and -3 levels with clinical findings and ultrasonographic skin thickness in systemic sclerosis patients.	SCUBE1 SCUBE2	1.20e-05	3	70	2	31991528
Pubmed	Natural substrates and inhibitors of mannan-binding lectin-associated serine protease-1 and -2: a study on recombinant catalytic fragments.	MASP1 MASP2	1.20e-05	3	70	2	12538697
Pubmed	Oligomerization of Mannan-binding Lectin Dictates Binding Properties and Complement Activation.	MASP1 MASP2	1.20e-05	3	70	2	27104295
Pubmed	Identification of a novel family of cell-surface proteins expressed in human vascular endothelium.	SCUBE1 SCUBE2	1.20e-05	3	70	2	12270931
Pubmed	Interaction properties of human mannan-binding lectin (MBL)-associated serine proteases-1 and -2, MBL-associated protein 19, and MBL.	MASP1 MASP2	1.20e-05	3	70	2	11290788
Pubmed	Activation of the lectin complement pathway by H-ficolin (Hakata antigen).	MASP1 MASP2	1.20e-05	3	70	2	11907111
Pubmed	MASP interactions with plasma-derived MBL.	MASP1 MASP2	1.20e-05	3	70	2	22607836
Pubmed	Human chromosome 11 DNA sequence and analysis including novel gene identification.	ZP1 TMPRSS13 OR56A5 ZNF75CP	2.12e-05	80	70	4	16554811
Pubmed	Co-complexes of MASP-1 and MASP-2 associated with the soluble pattern-recognition molecules drive lectin pathway activation in a manner inhibitable by MAp44.	MASP1 MASP2	2.39e-05	4	70	2	23785123
Pubmed	The chaperone and potential mannan-binding lectin (MBL) co-receptor calreticulin interacts with MBL through the binding site for MBL-associated serine proteases.	MASP1 MASP2	2.39e-05	4	70	2	18177377
Pubmed	Heteromeric complexes of native collectin kidney 1 and collectin liver 1 are found in the circulation with MASPs and activate the complement system.	MASP1 MASP2	2.39e-05	4	70	2	24174618
Pubmed	Cutting edge: complement-activating complex of ficolin and mannose-binding lectin-associated serine protease.	MASP1 MASP2	2.39e-05	4	70	2	10679061
Pubmed	Proteolytic activities of two types of mannose-binding lectin-associated serine protease.	MASP1 MASP2	2.39e-05	4	70	2	10946292
Pubmed	Experimentally-induced anti-myeloperoxidase vasculitis does not require properdin, MASP-2 or bone marrow-derived C5.	CFP MASP2	2.39e-05	4	70	2	27235854
Pubmed	The ZNF75 zinc finger gene subfamily: isolation and mapping of the four members in humans and great apes.	ZNF75A ZNF75CP	2.39e-05	4	70	2	8661144
Pubmed	Characterization of the interaction between L-ficolin/p35 and mannan-binding lectin-associated serine proteases-1 and -2.	MASP1 MASP2	2.39e-05	4	70	2	12421953
Pubmed	Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.	FBLN2 ASPN CELA2A LAMA5 ECM1	2.83e-05	175	70	5	28071719
Pubmed	Toward a structure-based comprehension of the lectin pathway of complement.	MASP1 MASP2	3.98e-05	5	70	2	23911397
Pubmed	A novel PCR-based technique using expressed sequence tags and gene homology for murine genetic mapping: localization of the complement genes.	MASP1 MASP2	3.98e-05	5	70	2	10700458
Pubmed	Scube3 is expressed in multiple tissues during development but is dispensable for embryonic survival in the mouse.	SCUBE1 SCUBE2	3.98e-05	5	70	2	23383134
Pubmed	Essential role of mannose-binding lectin-associated serine protease-1 in activation of the complement factor D.	MASP1 MASP2	3.98e-05	5	70	2	20038603
Pubmed	The cytoplasmic tail of fibrocystin contains a ciliary targeting sequence.	PKHD1 PKHD1L1	3.98e-05	5	70	2	20048263
Pubmed	Ficolin A and ficolin B are expressed in distinct ontogenic patterns and cell types in the mouse.	MASP1 MASP2	5.96e-05	6	70	2	15950722
Pubmed	Interaction of C1q and mannan-binding lectin (MBL) with C1r, C1s, MBL-associated serine proteases 1 and 2, and the MBL-associated protein MAp19.	MASP1 MASP2	5.96e-05	6	70	2	10878362
Pubmed	Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes.	SH2D2A ECM1	8.33e-05	7	70	2	10964718
Pubmed	Disruption of Scube2 Impairs Endochondral Bone Formation.	SCUBE1 SCUBE2	8.33e-05	7	70	2	25639508
Pubmed	Arf4 is required for Mammalian development but dispensable for ciliary assembly.	PKHD1 PKHD1L1	8.33e-05	7	70	2	24586199
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ZNF532 SZT2 LAMA5 FASTKD2 NUP188 RGP1 RAI1	9.49e-05	529	70	7	14621295
Pubmed	Bridging expressed sequence alignments through targeted cDNA sequencing.	SCUBE1 SZT2	1.11e-04	8	70	2	15028280
Pubmed	Npa3 interacts with Gpn3 and assembly factor Rba50 for RNA polymerase II biogenesis.	RPAP1 POLR2B	1.11e-04	8	70	2	32985767
Pubmed	Gene expression in mouse oocytes and preimplantation embryos: use of suppression subtractive hybridization to identify oocyte- and embryo-specific genes.	ZP1 UMODL1	1.11e-04	8	70	2	12493692
Pubmed	Defective lymphatic valve development and chylothorax in mice with a lymphatic-specific deletion of Connexin43.	FLT4 LAMA5	2.17e-04	11	70	2	27899284
Pubmed	Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.	FBLN2 ASPN LAMA5 ECM1	2.20e-04	146	70	4	27068509
Pubmed	RPAP1, a novel human RNA polymerase II-associated protein affinity purified with recombinant wild-type and mutated polymerase subunits.	RPAP1 POLR2B	2.60e-04	12	70	2	15282305
Pubmed	Developmental activities of the complement pathway in migrating neurons.	MASP1 MASP2	2.60e-04	12	70	2	28462915
Pubmed	Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.	FBLN2 ASPN LAMA5 ECM1	2.63e-04	153	70	4	25037231
Pubmed	Syndecan 4 controls lymphatic vasculature remodeling during mouse embryonic development.	FLT4 LAMA5	3.07e-04	13	70	2	27789626
Pubmed	Mesangial cells organize the glomerular capillaries by adhering to the G domain of laminin alpha5 in the glomerular basement membrane.	FBLN2 LAMA5	3.07e-04	13	70	2	12682087
Pubmed	Tie1 is required for lymphatic valve and collecting vessel development.	FLT4 LAMA5	3.58e-04	14	70	2	25576926
Pubmed	Smooth muscle-endothelial cell communication activates Reelin signaling and regulates lymphatic vessel formation.	FLT4 LAMA5	3.58e-04	14	70	2	22665518
Pubmed	The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.	FBLN2 ASPN LAMA5 ECM1	3.67e-04	167	70	4	22159717
Pubmed	Differential expression of the actin-binding proteins, alpha-actinin-2 and -3, in different species: implications for the evolution of functional redundancy.	ZP1 LIPE	4.12e-04	15	70	2	11440986
Pubmed	Cell-matrix signals specify bone endothelial cells during developmental osteogenesis.	FLT4 LAMA5	4.71e-04	16	70	2	28218908
Pubmed	Segregated Foxc2, NFATc1 and Connexin expression at normal developing venous valves, and Connexin-specific differences in the valve phenotypes of Cx37, Cx43, and Cx47 knockout mice.	FLT4 LAMA5	4.71e-04	16	70	2	26953188
Pubmed	Polydom Is an Extracellular Matrix Protein Involved in Lymphatic Vessel Remodeling.	FLT4 LAMA5	4.71e-04	16	70	2	28179430
Pubmed	Mechanotransduction, PROX1, and FOXC2 cooperate to control connexin37 and calcineurin during lymphatic-valve formation.	FLT4 LAMA5	5.33e-04	17	70	2	22306086
Pubmed	GATA2 controls lymphatic endothelial cell junctional integrity and lymphovenous valve morphogenesis through miR-126.	FLT4 LAMA5	5.98e-04	18	70	2	31582413
Pubmed	SCUBE3 loss-of-function causes a recognizable recessive developmental disorder due to defective bone morphogenetic protein signaling.	SCUBE1 SCUBE2	5.98e-04	18	70	2	33308444
Pubmed	Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis.	FLT4 LAMA5	5.98e-04	18	70	2	19686679
Pubmed	Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network.	SCUBE1 TMEM18	6.68e-04	19	70	2	23149075
Pubmed	Multiple roles of lymphatic vessels in peripheral lymph node development.	FLT4 LAMA5	7.41e-04	20	70	2	30355615
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	ZP1 TEPSIN ZSCAN10 AGO3 RIMBP2 GNB3 ADCY2 ADGRD1 TMEM18	8.43e-04	1242	70	9	30973865
Pubmed	Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation.	FBLN2 ASPN LAMA5	1.01e-03	97	70	3	27559042
Pubmed	Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse.	FLII RAI1	1.07e-03	24	70	2	11997338
Pubmed	Proteomics characterization of extracellular space components in the human aorta.	ASPN LAMA5 CFP	1.13e-03	101	70	3	20551380
Pubmed	Cannabinoid inhibits HIV-1 Tat-stimulated adhesion of human monocyte-like cells to extracellular matrix proteins.	LAMA5 ECM1	1.26e-03	26	70	2	24742657
Pubmed	Penetrance of craniofacial anomalies in mouse models of Smith-Magenis syndrome is modified by genomic sequence surrounding Rai1: not all null alleles are alike.	FLII RAI1	1.36e-03	27	70	2	17273973
Pubmed	Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins.	ZP1 NOP9 PDP1 CFP RIMBP2 ADCY2 PLK3	1.42e-03	832	70	7	36724073
Pubmed	Glucagon and regulation of glucose metabolism.	GNB3 ADCY2	1.79e-03	31	70	2	12626323
Pubmed	Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.	FLT4 CFP ECM1 CD163	1.82e-03	257	70	4	16335952
Pubmed	The TIP60 Complex Is a Conserved Coactivator of HIF1A.	FLII PDP1 POLR2B	1.85e-03	120	70	3	27320910
Pubmed	AMPK Interactome Reveals New Function in Non-homologous End Joining DNA Repair.	PKHD1 SCNN1D PARS2	1.90e-03	121	70	3	31900314
Pubmed	Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study.	MASP1 MASP2	1.90e-03	32	70	2	18842294
Pubmed	Severe obesity is associated with novel single nucleotide polymorphisms of the ESR1 and PPARgamma locus in Han Chinese.	LIPE GNB3	1.90e-03	32	70	2	19491387
Cytoband	1p36.3-p36.2	SCNN1D MASP2	1.37e-05	4	70	2	1p36.3-p36.2
Cytoband	17q21.2	KRTAP4-7 KRTAP4-11 KRTAP4-9	1.73e-04	70	70	3	17q21.2
GeneFamily	Keratin associated proteins	KRTAP4-7 KRTAP4-11 KRTAP4-6 KRTAP4-9	1.41e-04	109	44	4	619
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF672 ZBTB39 ZBTB20 ZSCAN10 ZNF532 ZNF75A ZNF700 ZXDA	2.97e-04	718	44	8	28
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRAPPC3L PKHD1 RIMBP2 PKHD1L1 ADCY2	5.36e-06	160	70	5	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRAPPC3L PKHD1 RIMBP2 PKHD1L1 ADCY2	5.36e-06	160	70	5	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MASP1 SCUBE1 FBLN2 ZNF700 ECM1	9.51e-06	180	70	5	40d4838a0ccb10d5e49266bc8a0037d27b75ccc2
ToppCell	facs-Kidney-nan-24m-Mesenchymal-kidney_interstitial_fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBLN2 CDCA7 FUT7 ECM1 ADGRD1	9.76e-06	181	70	5	c7f5aedcb74c21fb587a95a16d700e2a38a380ee
ToppCell	facs-Kidney-nan-24m-Mesenchymal-kidney_interstitial_fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBLN2 CDCA7 FUT7 ECM1 ADGRD1	9.76e-06	181	70	5	0ec9621a078d004bbd25a587757d24b5cf162959
ToppCell	368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	NOP9 FBLN2 SCUBE2 LAMA5 CFP	1.11e-05	186	70	5	77bebf576eb9b96ecb4fefb8a82a31aaaa917fc0
ToppCell	368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	NOP9 FBLN2 SCUBE2 LAMA5 CFP	1.11e-05	186	70	5	13bc41c60fd628af31899a5e8b480e06cc4781be
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM202 FBLN2 ECM1 PKHD1L1 ADGRD1	1.14e-05	187	70	5	4e553721fa5598cb211f44e3226280b7e6885484
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM202 FBLN2 ECM1 PKHD1L1 ADGRD1	1.14e-05	187	70	5	d36e7fc6125e7a4310499365022d38f34b757a73
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM202 FBLN2 ECM1 PKHD1L1 ADGRD1	1.14e-05	187	70	5	827eae63fabf6892a82ce7779b5f395958d3d628
ToppCell	facs-Trachea-24m-Mesenchymal\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FBLN2 ZBTB20 ASPN ECM1 ADGRD1	1.30e-05	192	70	5	e8af6ad1ae99cae13a82d0d8d7f38af9b777f0ba
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	NPHP3 UMODL1 CELA2A KIAA1958 ZXDA	1.47e-05	197	70	5	fd76cc5e12c7e7943a48f739e4f0626ff7211f51
Disease	Smith-Magenis syndrome	FLII RAI1	3.04e-05	4	67	2	C0795864
Disease	Autosomal Recessive Polycystic Kidney Disease	NPHP3 PKHD1	1.81e-04	9	67	2	C0085548
Disease	Obesity	GNB3 CD163 RAI1 TMEM18	1.23e-03	205	67	4	C0028754

Protein segments in the cluster

Peptide	Gene	Start	Entry
INLEGSYTCQCRTTR	UMODL1	526	Q5DID0
RGNLTYSVCRCTHLT	ADGRD1	531	Q6QNK2
AAHCISSSRTYRVGL	CELA2A	71	P08217
QLCHTYVRCTRSVSI	AGO3	786	Q9H9G7
SSYSERCRGHVCQVV	DIPK1B	51	Q5VUD6
CYSRVVHCSDLGLTS	ASPN	81	Q9BXN1
TSARGLSRRLQSCYC	RAI1	1771	Q7Z5J4
CAHLCNAVIGYLSTR	NOP9	296	Q86U38
TCSSHLTVVLLQYGC	OR10W1	231	Q8NGF6
LYQIRTNGSALCTRC	FLII	1056	Q13045
KESTQGHRSYLLTCC	FAM86C1P	76	Q9NVL1
RLCQHTCENTLGSYR	FBLN2	911	P98095
CCYVSRRLSQLSSHD	FBXO3	36	Q9UK99
DTCTRYGIARCHLSA	FUT7	66	Q11130
GRVSCHTTCYRPTCV	KRTAP4-11	166	Q9BYQ6
SRELSAHTGYLSCCR	GNB3	136	P16520
TCHLRGTSECTQLRA	TEPSIN	286	Q96N21
VTCSEGSQLRYRRCV	CFP	91	P27918
SLHPCLYSTLCRGTA	LAMA5	1141	O15230
HLCCSSSYIPQSRLR	PDP1	31	Q9P0J1
SCTAHVFSCLSLRLR	PAQR9	136	Q6ZVX9
SSRLRYCAGHIIKNC	OR56A5	166	P0C7T3
LDSRAYLNSSVCHCL	MALRD1	331	Q5VYJ5
TSLVLQTLGYTCTCR	ADCY2	1046	Q08462
CSCRFGYILHTDNRT	MASP1	166	P48740
SCRAGYVLHRNKRTC	MASP2	166	O00187
YVLHRNKRTCSALCS	MASP2	171	O00187
GRVSCHTTCYRPTCV	KRTAP4-6	176	Q9BYQ5
GRVSCHTTCYRPTCV	KRTAP4-7	181	Q9BYR0
GRVSCHTTCYRPTCV	KRTAP4-9	181	Q9BYQ8
GYSRCCHCRSHTNRL	ECM1	216	Q16610
TCSHSRDVGVVCSRY	CD163	566	Q86VB7
KESTQGHRSYLLTCC	FAM86C2P	76	A6NEL3
TTTHRCIRCPVGTYQ	SCUBE1	751	Q8IWY4
NTTTHRCIRCPVGTY	SCUBE2	761	Q9NQ36
LHNTSYTRQACLVSC	SCNN1D	546	P51172
NGYRSLVHTARCCLA	LIPE	371	Q05469
TCSRQLSGYVPCRFH	PARS2	16	Q7L3T8
SNGRYSTIQCRISHS	SZT2	601	Q5T011
ACTYRISVQCVTSRG	RIMBP2	361	O15034
VTFVLTYRSRTCCRH	SH2D2A	126	Q9NP31
TYRSRTCCRHFLLAQ	SH2D2A	131	Q9NP31
ERHCRSATTCNALYV	NPHP3	701	Q7Z494
TSCRSLHLYNISDGR	RGP1	206	Q92546
VLCVSRSAYCLGSSH	FASTKD2	636	Q9NYY8
RTHTYECRGCRNKTQ	POLR2B	1131	P30876
NCPTVTCTSHYRRVG	PKHD1	3621	P08F94
IYNRSLGSTCHQCRQ	CDCA7	261	Q9BWT1
SACTYLASHLRQLGC	PLK3	611	Q9H4B4
RECGLCYTSHVSLSR	ZNF532	1206	Q9HCE3
RCCNSLRYHERTHTG	ZNF700	546	Q9H0M5
VCSTCRAQLRGQHFY	TRIP6	306	Q15654
VLCSHCGQSFQRRSS	ZSCAN10	421	Q96SZ4
SQRYISLQCSHCGLR	TMPRSS13	306	Q9BYE2
LRGLVYLFCSTSACH	ZP1	521	P60852
VTTLGQFCQLCSRRY	IGHMBP2	906	P38935
RTHTGEQPYTCSICR	ZNF75CP	396	Q92670
RRTHAGQTLYICSEC	ZNF672	61	Q499Z4
LIGCILYSCLTSTTR	SERINC5	321	Q86VE9
SRHSRQALTCTAYGV	FLT4	436	P35916
LGYLCQACTSLLHSR	NUP188	1481	Q5SRE5
CAGYTCQRRLSLFHS	PKHD1L1	3806	Q86WI1
RNCYLTHCSPARASL	RPAP1	1056	Q9BWH6
VTHTGVRAYQCSICN	ZBTB20	626	Q9HC78
YRCTVCGHYSSTLNL	ZBTB39	661	O15060
GCCARFSARSSLYIH	ZXDA	516	P98168
CHSCNRVGYFSIRKS	XKR3	441	Q5GH77
ARSCVGRCHSYSEII	TRAPPC3L	61	Q5T215
THTGEQPYTCSICRR	ZNF75A	266	Q96N20
QAHIYIRTLCGSLCS	TMEM202	51	A6NGA9
LTCLSSRSYRLQIGH	TMEM18	41	Q96B42
SFTQVSRRLGSHSCC	KIAA1958	701	Q8N8K9