Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR1N1 OR51L1 OR14K1 HCAR3 GPR50 OR4K17 OR4C6 OR4A16 OR4A15 OR4K1 MTNR1B OR4D1 OR4C46 OR1F12P OR4C13 OR4C12 CCR6 ADGRV1 OR14C36 PTAFR OR4D5 OR4X1 PTGER4 OR4C5 OR4L1 OR4F6

4.61e-218845526GO:0004930
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

SORT1 OR1N1 OR51L1 OR14K1 HCAR3 GPR50 CRIM1 OR4K17 OR4C6 OR4A16 OR4A15 OR4K1 MTNR1B OR4D1 OR4C46 OR1F12P OR4C13 OR4C12 CCR6 ADGRV1 OR14C36 PTAFR OR4D5 OR4X1 PTGER4 OR4C5 OR4L1 OR4F6

9.09e-1913535528GO:0004888
GeneOntologyMolecularFunctionolfactory receptor activity

OR1N1 OR51L1 OR14K1 OR4K17 OR4C6 OR4A16 OR4A15 OR4K1 OR4D1 OR4C46 OR1F12P OR4C13 OR4C12 OR14C36 OR4D5 OR4X1 OR4C5 OR4L1 OR4F6

2.07e-184315519GO:0004984
GeneOntologyMolecularFunctionmelatonin receptor activity

GPR50 MTNR1B

4.45e-054552GO:0008502
GeneOntologyMolecularFunctionvery-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity

HACD2 HACD1

4.45e-054552GO:0102158
GeneOntologyMolecularFunction3-hydroxyacyl-CoA dehydratase activity

HACD2 HACD1

2.06e-048552GO:0018812
GeneOntologyMolecularFunctionenoyl-CoA hydratase activity

HACD2 HACD1

4.83e-0412552GO:0004300
GeneOntologyMolecularFunctionnucleotide receptor activity

HCAR3 PTAFR

1.66e-0322552GO:0016502
GeneOntologyMolecularFunctionpurinergic nucleotide receptor activity

HCAR3 PTAFR

1.66e-0322552GO:0001614
GeneOntologyBiologicalProcesssensory perception of smell

OR1N1 OR51L1 OR14K1 OR4K17 OR4C6 OR4A16 OR4A15 OR4K1 OR4D1 OR4C46 OR1F12P OR4C13 OR4C12 OR14C36 OR4D5 OR4X1 ADCY3 OR4C5 OR4L1 OR4F6

1.87e-194655520GO:0007608
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

SORT1 OR1N1 OR51L1 OR14K1 HCAR3 GPR50 OR4K17 OR4C6 OR4A16 OR4A15 OR4K1 MTNR1B OR4D1 OR4C46 OR1F12P OR4C13 OR4C12 CCR6 ADGRV1 OR14C36 PTAFR OR4D5 OR4X1 PTGER4 ADCY3 OR4C5 OR4L1 OR4F6

8.72e-1913955528GO:0007186
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of smell

OR1N1 OR51L1 OR14K1 OR4K17 OR4C6 OR4A16 OR4A15 OR4K1 OR4D1 OR4C46 OR1F12P OR4C13 OR4C12 OR14C36 OR4D5 OR4X1 OR4C5 OR4L1 OR4F6

1.19e-184325519GO:0050911
GeneOntologyBiologicalProcesssensory perception of chemical stimulus

OR1N1 OR51L1 OR14K1 OR4K17 OR4C6 OR4A16 OR4A15 OR4K1 OR4D1 OR4C46 OR1F12P OR4C13 OR4C12 OR14C36 OR4D5 OR4X1 ADCY3 OR4C5 OR4L1 OR4F6

4.48e-185475520GO:0007606
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception

OR1N1 OR51L1 OR14K1 OR4K17 OR4C6 OR4A16 OR4A15 OR4K1 OR4D1 OR4C46 OR1F12P OR4C13 OR4C12 OR14C36 OR4D5 OR4X1 OR4C5 OR4L1 OR4F6

1.03e-174855519GO:0050907
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

OR1N1 OR51L1 OR14K1 OR4K17 OR4C6 OR4A16 OR4A15 OR4K1 OR4D1 OR4C46 OR1F12P OR4C13 OR4C12 ADGRV1 OR14C36 OR4D5 OR4X1 OR4C5 OR4L1 OR4F6

1.49e-175825520GO:0050906
GeneOntologyBiologicalProcessdetection of chemical stimulus

OR1N1 OR51L1 OR14K1 OR4K17 OR4C6 OR4A16 OR4A15 OR4K1 OR4D1 OR4C46 OR1F12P OR4C13 OR4C12 OR14C36 OR4D5 OR4X1 OR4C5 OR4L1 OR4F6

4.30e-175245519GO:0009593
GeneOntologyBiologicalProcessdetection of stimulus

OR1N1 OR51L1 OR14K1 OR4K17 OR4C6 OR4A16 OR4A15 OR4K1 OR4D1 OR4C46 OR1F12P OR4C13 OR4C12 ADGRV1 OR14C36 OR4D5 OR4X1 OR4C5 OR4L1 OR4F6

9.41e-167225520GO:0051606
GeneOntologyBiologicalProcesssensory perception

OR1N1 OR51L1 OR14K1 OR4K17 OR4C6 OR4A16 OR4A15 OR4K1 OR4D1 OR4C46 OR1F12P OR4C13 OR4C12 ADGRV1 OR14C36 OR4D5 OR4X1 ADCY3 OR4C5 OR4L1 OR4F6

1.38e-1310725521GO:0007600
GeneOntologyBiologicalProcessregulation of gastro-intestinal system smooth muscle contraction

PTAFR PTGER4

2.48e-049552GO:1904304
GeneOntologyBiologicalProcesspositive regulation of circadian sleep/wake cycle, non-REM sleep

MTNR1B PTGER4

2.48e-049552GO:0046010
Domain7tm_1

OR1N1 OR51L1 OR14K1 HCAR3 GPR50 OR4K17 OR4C6 OR4A16 OR4A15 OR4K1 MTNR1B OR4D1 OR4C46 OR1F12P OR4C13 OR4C12 CCR6 OR14C36 PTAFR OR4D5 OR4X1 PTGER4 OR4C5 OR4L1 OR4F6

3.89e-226775425PF00001
DomainG_PROTEIN_RECEP_F1_1

OR1N1 OR51L1 OR14K1 HCAR3 GPR50 OR4K17 OR4C6 OR4A16 OR4A15 OR4K1 MTNR1B OR4D1 OR4C46 OR1F12P OR4C13 OR4C12 CCR6 OR14C36 PTAFR OR4D5 OR4X1 PTGER4 OR4C5 OR4L1 OR4F6

5.18e-226855425PS00237
DomainG_PROTEIN_RECEP_F1_2

OR1N1 OR51L1 OR14K1 HCAR3 GPR50 OR4K17 OR4C6 OR4A16 OR4A15 OR4K1 MTNR1B OR4D1 OR4C46 OR1F12P OR4C13 OR4C12 CCR6 OR14C36 PTAFR OR4D5 OR4X1 PTGER4 OR4C5 OR4L1 OR4F6

6.41e-226915425PS50262
DomainGPCR_Rhodpsn

OR1N1 OR51L1 OR14K1 HCAR3 GPR50 OR4K17 OR4C6 OR4A16 OR4A15 OR4K1 MTNR1B OR4D1 OR4C46 OR1F12P OR4C13 OR4C12 CCR6 OR14C36 PTAFR OR4D5 OR4X1 PTGER4 OR4C5 OR4L1 OR4F6

6.64e-226925425IPR000276
DomainOlfact_rcpt

OR1N1 OR51L1 OR14K1 OR4K17 OR4C6 OR4A16 OR4A15 OR4K1 OR4D1 OR4C46 OR1F12P OR4C13 OR4C12 OR14C36 OR4D5 OR4X1 OR4C5 OR4L1 OR4F6

8.36e-193935419IPR000725
DomainGPCR_Rhodpsn_7TM

OR1N1 OR51L1 HCAR3 GPR50 OR4K17 OR4C6 OR4A16 OR4A15 OR4K1 MTNR1B OR4D1 OR4C46 OR4C13 OR4C12 CCR6 OR14C36 PTAFR OR4D5 OR4X1 PTGER4 OR4L1 OR4F6

3.03e-186705422IPR017452
DomainMelatonin_rcpt

GPR50 MTNR1B

2.46e-053542IPR000025
DomainPTPLA

HACD2 HACD1

4.90e-054542PF04387
DomainTyr_Pase-like_PTPLA

HACD2 HACD1

4.90e-054542IPR007482
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR1N1 OR51L1 OR14K1 OR4K17 OR4C6 OR4A16 OR4A15 OR4K1 OR4D1 OR4C46 OR1F12P OR4C13 OR4C12 OR14C36 OR4D5 OR4X1 ADCY3 OR4C5 OR4L1 OR4F6

2.69e-194174520M4072
PathwayREACTOME_SENSORY_PERCEPTION

OR1N1 OR51L1 OR14K1 OR4K17 OR4C6 OR4A16 OR4A15 OR4K1 OR4D1 OR4C46 OR1F12P OR4C13 OR4C12 OR14C36 OR4D5 OR4X1 ADCY3 OR4C5 OR4L1 OR4F6

1.00e-156364520M41834
PathwayKEGG_OLFACTORY_TRANSDUCTION

OR1N1 OR51L1 OR4K17 OR4C6 OR4A16 OR4A15 OR4K1 OR4D1 OR4C46 OR4C13 OR4C12 OR14C36 OR4D5 OR4X1 ADCY3 OR4L1 OR4F6

1.20e-153894517M14091
PathwayWP_SMALL_LIGAND_GPCRS

GPR50 MTNR1B PTAFR PTGER4

3.39e-0719454M39728
PathwayWP_GPCRS_SMALL_LIGAND

MTNR1B PTAFR PTGER4

2.40e-0518453MM15858
PathwayWP_GPCRS_CLASS_A_RHODOPSINLIKE

HCAR3 GPR50 MTNR1B CCR6 PTAFR PTGER4

1.66e-04260456M39397
PathwayWP_GPCRS_NONODORANT

HCAR3 GPR50 MTNR1B CCR6 PTAFR PTGER4

1.87e-04266456MM15843
PathwayWP_GPCRS_CLASS_A_RHODOPSINLIKE

HCAR3 GPR50 CCR6 PTAFR PTGER4

3.02e-04186455MM15994
Pubmed

The human olfactory receptor gene family.

OR1N1 OR51L1 OR14K1 OR4K17 OR4C6 OR4A16 OR4A15 OR4K1 OR4D1 OR1F12P OR4C13 OR4C12 OR14C36 OR4D5 OR4X1 OR4C5 OR4L1 OR4F6

1.82e-19541551814983052
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR1N1 OR4C6 OR4A16 OR4A15 OR4K1 OR4D1 OR4C46 OR1F12P OR4C13 OR4C12 OR14C36 OR4D5 OR4C5 OR4L1 OR4F6

4.37e-18340551511875048
Pubmed

The olfactory receptor gene superfamily of the mouse.

OR1N1 OR4C6 OR4A16 OR4A15 OR4K1 OR4D1 OR4C46 OR1F12P OR4C13 OR4C12 OR14C36 OR4D5 OR4C5 OR4L1 OR4F6

4.37e-18340551511802173
Pubmed

A unified nomenclature for vertebrate olfactory receptors.

OR1N1 OR4C6 OR4A16 OR4A15 OR4K1 OR4D1 OR4C46 OR1F12P OR4C13 OR4C12 OR14C36 OR4D5 OR4C5 OR4L1 OR4F6

4.98e-18343551532295537
Pubmed

Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.

OR1N1 OR4C6 OR4A16 OR4A15 OR4K1 OR4D1 OR4C46 OR1F12P OR4C13 OR4C12 OR14C36 OR4D5 OR4C5 OR4L1 OR4F6

5.67e-18346551514611657
Pubmed

DEFOG: a practical scheme for deciphering families of genes.

OR1N1 OR14K1 OR4A15 OR4K1 OR4D1 OR4C13 OR4C12

5.60e-0821955712213199
Pubmed

Cloning of a melatonin-related receptor from human pituitary.

GPR50 MTNR1B

2.46e-0625528647286
Pubmed

The 3-hydroxyacyl-CoA dehydratases HACD1 and HACD2 exhibit functional redundancy and are active in a wide range of fatty acid elongation pathways.

HACD2 HACD1

2.46e-06255228784662
Pubmed

Molecular cloning, chromosomal mapping, and developmental expression of a novel protein tyrosine phosphatase-like gene.

HACD2 HACD1

2.46e-06255210644438
Pubmed

The 3-hydroxyacyl-CoA dehydratase 1/2 form complex with trans-2-enoyl-CoA reductase involved in substrates transfer in very long chain fatty acid elongation.

HACD2 HACD1

7.36e-06355238422897
Pubmed

Evaluation of GPR50, hMel-1B, and ROR-alpha melatonin-related receptors and the etiology of adolescent idiopathic scoliosis.

GPR50 MTNR1B

7.36e-06355220733416
Pubmed

Association of disease-predisposition polymorphisms of the melatonin receptors and sunshine duration in the global human populations.

GPR50 MTNR1B

7.36e-06355220050988
Pubmed

Chemokine receptor CCR6-dependent accumulation of γδ T cells in injured liver restricts hepatic inflammation and fibrosis.

CCR6 IL17F

7.36e-06355223959575
Pubmed

Identification of pathway-biased and deleterious melatonin receptor mutants in autism spectrum disorders and in the general population.

GPR50 MTNR1B

7.36e-06355220657642
Pubmed

Characterization of four mammalian 3-hydroxyacyl-CoA dehydratases involved in very long-chain fatty acid synthesis.

HACD2 HACD1

1.47e-05455218554506
Pubmed

Changes in melatonin receptor expression in a murine model of glaucoma.

GPR50 MTNR1B

1.47e-05455232818016
Pubmed

T helper 17 cells promote cytotoxic T cell activation in tumor immunity.

CCR6 IL17F

1.47e-05455219879162
Pubmed

Mutation screening of melatonin-related genes in patients with autism spectrum disorders.

GPR50 MTNR1B

2.45e-05555220377855
Pubmed

Functional activity of serotoninergic and melatoninergic systems expressed in the skin.

GPR50 MTNR1B

3.67e-05655212767050
Pubmed

HACD1, a regulator of membrane composition and fluidity, promotes myoblast fusion and skeletal muscle growth.

HACD2 HACD1

3.67e-05655226160855
Pubmed

The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization.

GPR50 MTNR1B

5.13e-05755216778767
Pubmed

Lymphatic migration of unconventional T cells promotes site-specific immunity in distinct lymph nodes.

CCR6 IL17F

1.10e-041055236002023
Pubmed

Odorant and vomeronasal receptor genes in two mouse genome assemblies.

OR4A16 OR14C36 OR4L1

2.24e-047455315081110
Pubmed

Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning.

ADGRV1 ADCY3

2.90e-041655217567809
Pubmed

Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.

SORT1 MTNR1B

7.79e-042655219060910
Pubmed

Modulation of the combinatorial code of odorant receptor response patterns in odorant mixtures.

OR4A16 OR14C36

8.40e-042755232061665
Pubmed

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.

CCR6 PTGER4

9.04e-042855218587394
Pubmed

Large-scale identification of human genes implicated in epidermal barrier function.

HCAR3 ITPRIP

1.04e-033055217562024
Pubmed

Evidence for significant overlap between common risk variants for Crohn's disease and ankylosing spondylitis.

CCR6 PTGER4

1.11e-033155221072187
Pubmed

A probabilistic classifier for olfactory receptor pseudogenes.

OR14K1 OR4X1

1.41e-033555216939646
CytobandEnsembl 112 genes in cytogenetic band chr11q11

OR4C6 OR4A16 OR4A15 OR4C46

1.63e-0740554chr11q11
Cytoband11p11.12

OR4C46 OR4C13 OR4C12

1.81e-054255311p11.12
Cytoband11q11

OR4C6 OR4A16 OR4A15

2.54e-054755311q11
CytobandEnsembl 112 genes in cytogenetic band chr11p11

OR4C13 OR4C12 OR4X1 OR4C5

3.54e-05153554chr11p11
Cytoband14q11.2

OR4K17 OR4K1 OR4L1

1.34e-0318055314q11.2
Cytoband11p11.2

OR4X1 OR4C5

4.51e-038355211p11.2
GeneFamilyOlfactory receptors, family 4

OR4K17 OR4C6 OR4A16 OR4A15 OR4K1 OR4D1 OR4C46 OR4C13 OR4C12 OR4D5 OR4X1 OR4C5 OR4L1 OR4F6

8.52e-211294014151
GeneFamilyOlfactory receptors, family 14

OR14K1 OR14C36

9.95e-057402163
GeneFamilyOlfactory receptors, family 1

OR1N1 OR1F12P

3.53e-0340402147
Drugrubraxanthone

PTAFR IL17F

1.47e-053512CID006450342
Drug2-methyl-6,7-dichloromelatonin

MTNR1B IL17F

1.47e-053512CID000128592
Drugagomelatine

GPR50 MTNR1B IL17F

1.82e-0523513CID000082148
Drug5-methoxyluzindole

MTNR1B IL17F

2.94e-054512CID000129776
Diseasefocal segmental glomerulosclerosis

KCNK6 OR4X1

3.46e-0416512EFO_0004236
Diseaseacute kidney failure (implicated_via_orthology)

PTAFR PTGER4

1.00e-0327512DOID:3021 (implicated_via_orthology)
DiseaseOvarian Cysts

TIMD4 PTGER4

1.68e-0335512C0029927
DiseaseCorpus Luteum Cyst

TIMD4 PTGER4

1.68e-0335512C0010093
DiseaseSclerocystic Ovaries

MTNR1B PTAFR HACD1

2.00e-03144513C1136382
DiseasePolycystic Ovary Syndrome

MTNR1B PTAFR HACD1

2.00e-03144513C0032460
Diseasetransient cerebral ischemia (biomarker_via_orthology)

CCR6 PTAFR PTGER4

2.55e-03157513DOID:224 (biomarker_via_orthology)
Diseaseocular hypertension, response to triamcinolone acetonide

COL24A1 CRPPA

3.27e-0349512EFO_0006954, EFO_1001069
DiseaseHOMA-B

MTNR1B CRPPA

4.10e-0355512EFO_0004469
Diseasemetabolic syndrome

HCAR3 TIMD4 MTNR1B

5.03e-03200513EFO_0000195
DiseaseObesity

CPB2 BBS12 ADCY3

5.39e-03205513C0028754

Protein segments in the cluster

PeptideGeneStartEntry
LLICVAAVAVFTTHI

DISP3

1191

Q9P2K9
LVPLTCLVVVFVVFI

ADGRV1

6066

Q8WXG9
IIAVVLVFLACQIPH

CCR6

256

P51684
ECLHLGVPISIIVSV

BBS12

101

Q6ZW61
FRVCLVVVTAIINHP

ITPRIP

6

Q8IWB1
SSLCILYPVVVVSVH

CRPPA

361

A4D126
LLGVVVTVCFLVPAV

KCNK6

176

Q9Y257
VTVCFLVPAVIFAHL

KCNK6

181

Q9Y257
ATVGLIFVVPSVCIL

OR1F12P

201

Q8NHA8
STCISHIIVVVLFFV

OR4C12

236

Q96R67
TAAVVVIHFLLPIAV

MTNR1B

201

P49286
PVFTVTIVCIHFVLP

GPR50

186

Q13585
TIVCIHFVLPLLIVG

GPR50

191

Q13585
FSTCIPHILVVSVFL

OR14C36

236

Q8NHC7
HVTVVILFFVPCIFL

OR4A15

271

Q8NGL6
FSNCVPHLIVVTVFL

OR14K1

236

Q8NGZ2
PHLIVVTVFLVTGAV

OR14K1

241

Q8NGZ2
PTCISHIIVVALVFV

OR4A16

236

Q8NH70
TCIPHLVVVTLFMIS

OR14L1P

241

Q8NHC6
HITVVILFFVPCIFV

OR4C46

241

A6NHA9
HICVVLIFFVPVIGV

OR51L1

246

Q8NGJ5
SAHVIVVVLVFGPLI

OR4F6

241

Q8NGB9
TAHITVVILFFGPCI

OR4K1

241

Q8NGD4
HITVVILFFGPCIFI

OR4K17

246

Q8NGC6
SAHIIVVTLFFGPCI

OR4L1

241

Q8NH43
HVTVVDLFFIPCSLV

OR4X1

241

Q8NH49
VLICSIPLVVRVFVN

PTGER4

281

P35408
FRVPHVAIFLSVVIC

MEAK7

201

Q6P9B6
HITVVILSFIPCIFV

OR4C13

241

Q8NGP0
VLVTVGCTCVTPVIH

IL17F

146

Q96PD4
HPSVSVVQILAFILI

CASD1

671

Q96PB1
LAVLVPIVLFCEQHV

CPB2

6

Q96IY4
FVIPVVQALLSRVVC

DDX51

266

Q8N8A6
IVHCLIGIVPTSVIV

HACD1

126

B0YJ81
EILHCAIGIVPSSVV

HACD2

91

Q6Y1H2
ASVVVPIIICLSIII

CRIM1

941

Q9NZV1
VIISVVSCVVHTLVL

ADCY3

191

O60266
LIFVTCPSLLVILHV

GJB3

81

O75712
TTHIIVVSMIFIPCI

OR4D1

241

Q15615
ASHIAVVTLIFVPCI

OR4D5

241

Q8NGN0
IVPFLCIVTSYIHIV

OR1N1

206

Q8NGS0
IAAAACTVILVIVVP

MINAR1

896

Q9UPX6
HITVVVLFFVPCILV

OR4C5

256

Q8NGB2
HLTVVVLFFVPCIFL

OR4C6

241

Q8NH72
TGVILVLTTFHVPLV

SORT1

121

Q99523
VCVSLVVFAILPVPV

SLC6A15

621

Q9H2J7
TVLAVFIICFVPHHV

PTAFR

236

P25105
VICFLPSVVVRIHIF

HCAR3

241

P49019
CVLAVTVTVLHPDFT

RNF26

236

Q9BY78
QIAAFLFTVCHVVIV

SMG9

306

Q9H0W8
VFVLLAVCIIVAVHF

SMIM33

51

A0A1B0GW64
TAIVIVIVSLCTTPI

SLC5A9

541

Q2M3M2
PIVSTIAIVLTLSCH

ABCC12

351

Q96J65
SLLHFIVLCVAGVVV

COL24A1

21

Q17RW2
VICIHDVSSTYRVPV

CTPS2

241

Q9NRF8
IEPIIAACVVIFLTL

TMIGD1

221

Q6UXZ0
ILCVVASIISIHPKI

SERINC3

246

Q13530
TVVTEVLGHRVTLPC

TIMD4

26

Q96H15
HCSTVIPVVVLTLKF

TMEM267

116

Q0VDI3