Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	sodium-independent organic anion transmembrane transporter activity	SLCO5A1 SLCO4A1 SLC22A7	1.94e-05	18	59	3	GO:0015347
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	KCNJ6 KCNJ9 BEST4 GABRQ CNGB1 ITPR2	2.22e-05	193	59	6	GO:0015276
GeneOntologyMolecularFunction	ligand-gated channel activity	KCNJ6 KCNJ9 BEST4 GABRQ CNGB1 ITPR2	2.49e-05	197	59	6	GO:0022834
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR2W3 GPR3 OR56B1 OR6N2 SIGMAR1 CXCR4 OPN3 OR6C4 TLR2 INSR GABRQ OR8G5 GRM4 S1PR1	2.98e-05	1353	59	14	GO:0004888
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR2W3 GPR3 OR56B1 OR6N2 SIGMAR1 CXCR4 OPN3 OR6C4 OR8G5 GRM4 S1PR1	4.80e-05	884	59	11	GO:0004930
GeneOntologyMolecularFunction	G-protein activated inward rectifier potassium channel activity	KCNJ6 KCNJ9	5.13e-05	4	59	2	GO:0015467
GeneOntologyMolecularFunction	alpha-1,4-glucosidase activity	MGAM SI	8.53e-05	5	59	2	GO:0004558
GeneOntologyMolecularFunction	alpha-glucosidase activity	MGAM SI	1.79e-04	7	59	2	GO:0090599
GeneOntologyMolecularFunction	gated channel activity	KCNJ6 KCNJ9 BEST4 GABRQ CNGB1 ITPR2	4.47e-04	334	59	6	GO:0022836
GeneOntologyMolecularFunction	prostaglandin transmembrane transporter activity	SLCO4A1 SLC22A7	7.63e-04	14	59	2	GO:0015132
GeneOntologyMolecularFunction	ligand-gated monoatomic cation channel activity	KCNJ6 KCNJ9 CNGB1 ITPR2	7.81e-04	140	59	4	GO:0099094
GeneOntologyMolecularFunction	icosanoid transmembrane transporter activity	SLCO4A1 SLC22A7	8.79e-04	15	59	2	GO:0071714
GeneOntologyMolecularFunction	glucosidase activity	MGAM SI	8.79e-04	15	59	2	GO:0015926
GeneOntologyMolecularFunction	monoatomic ion channel activity	KCNJ6 KCNJ9 BEST4 GABRQ CNGB1 ITPR2	2.30e-03	459	59	6	GO:0005216
GeneOntologyMolecularFunction	inward rectifier potassium channel activity	KCNJ6 KCNJ9	3.09e-03	28	59	2	GO:0005242
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR2W3 GPR3 OR56B1 OR6N2 SIGMAR1 CXCR4 OPN3 OR6C4 INSR OR8G5 GRM4 CNGB1 ADCY1 S1PR1 HTT	6.18e-06	1395	59	15	GO:0007186
GeneOntologyBiologicalProcess	detection of stimulus	OR2W3 OR56B1 OR6N2 CXCR4 OPN3 OR6C4 TLR2 TIMELESS OR8G5 CNGB1	3.45e-05	722	59	10	GO:0051606
GeneOntologyBiologicalProcess	disaccharide catabolic process	MGAM SI	4.81e-05	4	59	2	GO:0046352
Domain	Gal_mutarotase_SF_dom	MGAM BEST4 SI	2.08e-05	17	60	3	IPR011013
Domain	Glyco_hydro_31_CS	MGAM SI	6.06e-05	4	60	2	IPR030459
Domain	NtCtMGAM_N	MGAM SI	6.06e-05	4	60	2	PF16863
Domain	Gal_mutarotase_N	MGAM SI	6.06e-05	4	60	2	IPR031727
Domain	GLYCOSYL_HYDROL_F31_2	MGAM SI	1.01e-04	5	60	2	PS00707
Domain	Glyco_hydro_31_AS	MGAM SI	1.51e-04	6	60	2	IPR030458
Domain	Glyco_hydro_31	MGAM SI	2.11e-04	7	60	2	IPR000322
Domain	Glyco_hydro_31	MGAM SI	2.11e-04	7	60	2	PF01055
Domain	GLYCOSYL_HYDROL_F31_1	MGAM SI	2.11e-04	7	60	2	PS00129
Domain	GPCR_Rhodpsn_7TM	OR2W3 GPR3 OR56B1 OR6N2 CXCR4 OPN3 OR6C4 OR8G5 S1PR1	2.68e-04	670	60	9	IPR017452
Domain	Trefoil	MGAM SI	2.81e-04	8	60	2	PF00088
Domain	P_TREFOIL_1	MGAM SI	2.81e-04	8	60	2	PS00025
Domain	P_trefoil_CS	MGAM SI	2.81e-04	8	60	2	IPR017957
Domain	7tm_1	OR2W3 GPR3 OR56B1 OR6N2 CXCR4 OPN3 OR6C4 OR8G5 S1PR1	2.90e-04	677	60	9	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR2W3 GPR3 OR56B1 OR6N2 CXCR4 OPN3 OR6C4 OR8G5 S1PR1	3.16e-04	685	60	9	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR2W3 GPR3 OR56B1 OR6N2 CXCR4 OPN3 OR6C4 OR8G5 S1PR1	3.37e-04	691	60	9	PS50262
Domain	GPCR_Rhodpsn	OR2W3 GPR3 OR56B1 OR6N2 CXCR4 OPN3 OR6C4 OR8G5 S1PR1	3.40e-04	692	60	9	IPR000276
Domain	P_TREFOIL_2	MGAM SI	3.60e-04	9	60	2	PS51448
Domain	PD	MGAM SI	3.60e-04	9	60	2	SM00018
Domain	-	MGAM SI	5.48e-04	11	60	2	4.10.110.10
Domain	P_trefoil_dom	MGAM SI	6.56e-04	12	60	2	IPR000519
Domain	OA_transporter	SLCO5A1 SLCO4A1	6.56e-04	12	60	2	IPR004156
Domain	OATP	SLCO5A1 SLCO4A1	6.56e-04	12	60	2	PF03137
Domain	MFS_dom	SLCO5A1 SLCO4A1 OCLN SLC22A7	9.05e-04	134	60	4	IPR020846
Domain	K_chnl_inward-rec_Kir_cyto	KCNJ6 KCNJ9	1.18e-03	16	60	2	IPR013518
Domain	IRK	KCNJ6 KCNJ9	1.18e-03	16	60	2	PF01007
Domain	-	KCNJ6 KCNJ9	1.18e-03	16	60	2	2.60.40.1400
Domain	K_chnl_inward-rec_Kir	KCNJ6 KCNJ9	1.18e-03	16	60	2	IPR016449
Domain	Pentatricopeptide_repeat	DTNB HTT	2.46e-03	23	60	2	IPR002885
Domain	Ig_E-set	KCNJ6 KCNJ9 CD109	4.56e-03	104	60	3	IPR014756
Domain	MFS	SLCO5A1 SLCO4A1 SLC22A7	5.07e-03	108	60	3	PS50850
Domain	Kazal_2	SLCO5A1 SLCO4A1	5.96e-03	36	60	2	PF07648
Pathway	REACTOME_GABA_RECEPTOR_ACTIVATION	KCNJ6 KCNJ9 GABRQ ADCY1	5.02e-05	60	48	4	MM15708
Pathway	REACTOME_GABA_RECEPTOR_ACTIVATION	KCNJ6 KCNJ9 GABRQ ADCY1	5.02e-05	60	48	4	M976
Pubmed	S1PR1 regulates the quiescence of lymphatic vessels by inhibiting laminar shear stress-dependent VEGF-C signaling.	DLL4 CXCR4 S1PR1	6.11e-07	10	61	3	32544090
Pubmed	Pathogen induction of CXCR4/TLR2 cross-talk impairs host defense function.	CXCR4 TLR2	3.03e-06	2	61	2	18765807
Pubmed	Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease.	ATM HTT	3.03e-06	2	61	2	25540325
Pubmed	GIRK3 deletion facilitates kappa opioid signaling in chondrocytes, delays vascularization and promotes bone lengthening in mice.	KCNJ6 KCNJ9	3.03e-06	2	61	2	35314385
Pubmed	The sphingosine 1-phosphate receptor agonist FTY720 supports CXCR4-dependent migration and bone marrow homing of human CD34+ progenitor cells.	CXCR4 S1PR1	3.03e-06	2	61	2	14988150
Pubmed	Huntingtin is a scaffolding protein in the ATM oxidative DNA damage response complex.	ATM HTT	3.03e-06	2	61	2	28017939
Pubmed	Toll-like receptor 2-blocking antibodies promote angiogenesis and induce ERK1/2 and AKT signaling via CXCR4 in endothelial cells.	CXCR4 TLR2	3.03e-06	2	61	2	23723373
Pubmed	Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3.	KCNJ6 KCNJ9	3.03e-06	2	61	2	10956667
Pubmed	Mutations of the Huntington's disease protein impact on the ATM-dependent signaling and repair pathways of the radiation-induced DNA double-strand breaks: corrective effect of statins and bisphosphonates.	ATM HTT	3.03e-06	2	61	2	24277524
Pubmed	G-protein-gated potassium channels containing Kir3.2 and Kir3.3 subunits mediate the acute inhibitory effects of opioids on locus ceruleus neurons.	KCNJ6 KCNJ9	3.03e-06	2	61	2	12040038
Pubmed	GIRK2 splice variants and neuronal G protein-gated K+ channels: implications for channel function and behavior.	KCNJ6 KCNJ9	3.03e-06	2	61	2	28487514
Pubmed	Absence and rescue of morphine withdrawal in GIRK/Kir3 knock-out mice.	KCNJ6 KCNJ9	3.03e-06	2	61	2	18400906
Pubmed	Regulation of CXCR4 by the Notch ligand delta-like 4 in endothelial cells.	DLL4 CXCR4	3.03e-06	2	61	2	18339870
Pubmed	Interaction between the α-glucosidases, sucrase-isomaltase and maltase-glucoamylase, in human intestinal brush border membranes and its potential impact on disaccharide digestion.	MGAM SI	3.03e-06	2	61	2	36968271
Pubmed	The GARP Domain of the Rod CNG Channel's β1-Subunit Contains Distinct Sites for Outer Segment Targeting and Connecting to the Photoreceptor Disk Rim.	CD109 CNGB1	3.03e-06	2	61	2	33637563
Pubmed	Contribution of the Individual Small Intestinal α-Glucosidases to Digestion of Unusual α-Linked Glycemic Disaccharides.	MGAM SI	3.03e-06	2	61	2	27480812
Pubmed	Structural basis for substrate selectivity in human maltase-glucoamylase and sucrase-isomaltase N-terminal domains.	MGAM SI	3.03e-06	2	61	2	20356844
Pubmed	Pre- and postsynaptic regulation of locus coeruleus neurons after chronic morphine treatment: a study of GIRK-knockout mice.	KCNJ6 KCNJ9	3.03e-06	2	61	2	18702733
Pubmed	Pancreatic adenocarcinoma upregulated factor promotes metastasis by regulating TLR/CXCR4 activation.	CXCR4 TLR2	9.07e-06	3	61	2	20802527
Pubmed	Partial characterization of murine intestinal maltase-glucoamylase.	MGAM SI	9.07e-06	3	61	2	12150962
Pubmed	Hyperalgesia and blunted morphine analgesia in G protein-gated potassium channel subunit knockout mice.	KCNJ6 KCNJ9	9.07e-06	3	61	2	12499858
Pubmed	Specific expression of OATPs in primary small cell lung cancer (SCLC) cells as novel biomarkers for diagnosis and therapy.	SLCO5A1 SLCO4A1	9.07e-06	3	61	2	25301452
Pubmed	TLR2/CXCR4 coassociation facilitates Chlamydia pneumoniae infection-induced atherosclerosis.	CXCR4 TLR2	9.07e-06	3	61	2	32330088
Pubmed	Molecular cloning of a mouse G-protein-activated K+ channel (mGIRK1) and distinct distributions of three GIRK (GIRK1, 2 and 3) mRNAs in mouse brain.	KCNJ6 KCNJ9	9.07e-06	3	61	2	7702616
Pubmed	Mammalian TIMELESS is required for ATM-dependent CHK2 activation and G2/M checkpoint control.	TIMELESS ATM	9.07e-06	3	61	2	19996108
Pubmed	Identification of GIRK2-4 subunits in human esophageal smooth muscle cells.	KCNJ6 KCNJ9	9.07e-06	3	61	2	21637918
Pubmed	Developmental regulation of G protein-gated inwardly-rectifying K+ (GIRK/Kir3) channel subunits in the brain.	KCNJ6 KCNJ9	9.07e-06	3	61	2	22098295
Pubmed	Behavioral characterization of mice lacking GIRK/Kir3 channel subunits.	KCNJ6 KCNJ9	9.07e-06	3	61	2	18194467
Pubmed	Enhanced Chemokine Receptor Recycling and Impaired S1P1 Expression Promote Leukemic Cell Infiltration of Lymph Nodes in Chronic Lymphocytic Leukemia.	CXCR4 S1PR1	9.07e-06	3	61	2	26282174
Pubmed	Developmental expression of the GIRK family of inward rectifying potassium channels: implications for abnormalities in the weaver mutant mouse.	KCNJ6 KCNJ9	9.07e-06	3	61	2	9459542
Pubmed	Molecular and cellular diversity of neuronal G-protein-gated potassium channels.	KCNJ6 KCNJ9	9.07e-06	3	61	2	16339040
Pubmed	Altered neurotransmission in the mesolimbic reward system of Girk mice.	KCNJ6 KCNJ9	9.07e-06	3	61	2	20557431
Pubmed	Spinal G-protein-gated K+ channels formed by GIRK1 and GIRK2 subunits modulate thermal nociception and contribute to morphine analgesia.	KCNJ6 KCNJ9	9.07e-06	3	61	2	15028774
Pubmed	Co-expression of human Kir3 subunits can yield channels with different functional properties.	KCNJ6 KCNJ9	1.81e-05	4	61	2	10659995
Pubmed	TRIM24 is a p53-induced E3-ubiquitin ligase that undergoes ATM-mediated phosphorylation and autodegradation during DNA damage.	ATM TRIM24	1.81e-05	4	61	2	24820418
Pubmed	Molecular properties of neuronal G-protein-activated inwardly rectifying K+ channels.	KCNJ6 KCNJ9	1.81e-05	4	61	2	7499385
Pubmed	Functional analysis of the weaver mutant GIRK2 K+ channel and rescue of weaver granule cells.	KCNJ6 KCNJ9	1.81e-05	4	61	2	8630252
Pubmed	Structural characterization of the mouse Girk genes.	KCNJ6 KCNJ9	1.81e-05	4	61	2	11891065
Pubmed	S1P(1) overexpression stimulates S1P-dependent chemotaxis of human CD34+ hematopoietic progenitor cells but strongly inhibits SDF-1/CXCR4-dependent migration and in vivo homing.	CXCR4 S1PR1	1.81e-05	4	61	2	18760838
Pubmed	Expression of G-protein inwardly rectifying potassium channels (GIRKs) in lung cancer cell lines.	KCNJ6 KCNJ9	1.81e-05	4	61	2	16109170
Pubmed	Cell type-specific subunit composition of G protein-gated potassium channels in the cerebellum.	KCNJ6 KCNJ9	1.81e-05	4	61	2	18088366
Pubmed	Context-Specific Striatal Astrocyte Molecular Responses Are Phenotypically Exploitable.	HTT ITPR2	1.81e-05	4	61	2	33086039
Pubmed	Impact of Acute and Persistent Excitation of Prelimbic Pyramidal Neurons on Motor Activity and Trace Fear Learning.	KCNJ6 KCNJ9	3.02e-05	5	61	2	33402420
Pubmed	Subcellular compartment-specific molecular diversity of pre- and post-synaptic GABA-activated GIRK channels in Purkinje cells.	KCNJ6 KCNJ9	3.02e-05	5	61	2	19558451
Pubmed	Cloning provides evidence for a family of inward rectifier and G-protein coupled K+ channels in the brain.	KCNJ6 KCNJ9	3.02e-05	5	61	2	7926018
Pubmed	Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington's disease knock-in mice is blocked by Mlh1 knock-out.	MTMR10 HTT	4.52e-05	6	61	2	32876667
Pubmed	Reversal of female infertility by Chk2 ablation reveals the oocyte DNA damage checkpoint pathway.	ATM TRIP13	4.52e-05	6	61	2	24482479
Pubmed	Serum response factor is required for sprouting angiogenesis and vascular integrity.	DLL4 OCLN S1PR1	6.03e-05	43	61	3	18804439
Pubmed	The ATM signaling cascade promotes recombination-dependent pachytene arrest in mouse spermatocytes.	ATM TRIP13	6.32e-05	7	61	2	25768017
Pubmed	p53 and TAp63 participate in the recombination-dependent pachytene arrest in mouse spermatocytes.	ATM TRIP13	6.32e-05	7	61	2	28617799
Pubmed	The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.	ZBTB33 CD109 ATM TRIM24 ITPR2	9.85e-05	262	61	5	36880596
Pubmed	Notch1 expression and ligand interactions in progenitor cells of the mouse olfactory epithelium.	DLL4 CXCR4	1.08e-04	9	61	2	17605079
Pubmed	G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase.	KCNJ6 KCNJ9	1.08e-04	9	61	2	12297500
Pubmed	Dll4 and Notch signalling couples sprouting angiogenesis and artery formation.	DLL4 CXCR4	1.08e-04	9	61	2	28714968
Pubmed	LncRNA H19 Regulates BMP2-Induced Hypertrophic Differentiation of Mesenchymal Stem Cells by Promoting Runx2 Phosphorylation.	DLL4 S1PR1	1.08e-04	9	61	2	32903671
Pubmed	Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.	USP30 DTNB OTUB1 TIMELESS	1.33e-04	147	61	4	29576527
Pubmed	Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal proteins, are depleted from synapsed chromosome axes with the help of TRIP13 AAA-ATPase.	ATM TRIP13	1.35e-04	10	61	2	19851446
Pubmed	PRDM16 regulates arterial development and vascular integrity.	DLL4 CXCR4	1.65e-04	11	61	2	37324380
Pubmed	Molecular physiology of renal organic anion transporters.	SLCO4A1 SLC22A7	2.33e-04	13	61	2	16403838
Pubmed	Hypoxia-induced proteasomal degradation of DBC1 by SIAH2 in breast cancer progression.	USP30 OTUB1	2.33e-04	13	61	2	35913115
Pubmed	DNA methylation profiling in doxorubicin treated primary locally advanced breast tumours identifies novel genes associated with survival and treatment response.	CXCR4 ATM	2.72e-04	14	61	2	20338046
Pubmed	Phosphorylation of chromosome core components may serve as axis marks for the status of chromosomal events during mammalian meiosis.	ATM TRIP13	2.72e-04	14	61	2	22346761
Pubmed	International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels.	KCNJ6 KCNJ9	3.13e-04	15	61	2	16382105
Pubmed	Reelin and CXCL12 regulate distinct migratory behaviors during the development of the dopaminergic system.	CXCR4 KCNJ6	3.13e-04	15	61	2	24449842
Pubmed	Importance of endothelial Hey1 expression for thoracic great vessel development and its distal enhancer for Notch-dependent endothelial transcription.	DLL4 CXCR4	3.13e-04	15	61	2	33454003
Pubmed	ETS factors regulate Vegf-dependent arterial specification.	DLL4 CXCR4	3.13e-04	15	61	2	23830865
Pubmed	Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor.	COPS2 TRIP13	4.55e-04	18	61	2	7776974
Pubmed	On the integration of alcohol-related quantitative trait loci and gene expression analyses.	KCNJ9 SHOC2	4.55e-04	18	61	2	15597075
Pubmed	Chloride intracellular channel 4 is required for maturation of the cerebral collateral circulation.	DLL4 S1PR1	4.55e-04	18	61	2	26276819
Pubmed	CUEDC2, a novel interacting partner of the SOCS1 protein, plays important roles in the leukaemogenesis of acute myeloid leukaemia.	CXCR4 INSR ATM	4.90e-04	87	61	3	29991678
Pubmed	A plastic SQSTM1/p62-dependent autophagic reserve maintains proteostasis and determines proteasome inhibitor susceptibility in multiple myeloma cells.	INSR GFM2	5.08e-04	19	61	2	26043024
Pubmed	Analysis of microsatellite polymorphism in inbred knockout mice.	TLR2 ATM	5.63e-04	20	61	2	22509320
Pubmed	T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities.	NFE2L3 TRIM24	5.63e-04	20	61	2	11877444
Pubmed	HAND1 loss-of-function within the embryonic myocardium reveals survivable congenital cardiac defects and adult heart failure.	ADCY1 ITPR2	6.83e-04	22	61	2	31286141
Pubmed	Crosstalk between lysine methylation and phosphorylation of ATG16L1 dictates the apoptosis of hypoxia/reoxygenation-induced cardiomyocytes.	TLR2 ATM	6.83e-04	22	61	2	29634390
Pubmed	Rare independent mutations in renal salt handling genes contribute to blood pressure variation.	KCNJ6 KCNJ9	6.83e-04	22	61	2	18391953
Pubmed	Genome-wide identification of endothelial cell-enriched genes in the mouse embryo.	CD109 ARHGEF15	7.48e-04	23	61	2	22535667
Pubmed	Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.	INSR GABRQ ITPR2	7.57e-04	101	61	3	23382219
Pubmed	Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.	NFE2L3 ITPR2	8.15e-04	24	61	2	20935629
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	ATM TRIP13 HTT	8.24e-04	104	61	3	31240132
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	CXCR4 OTUB1 CD109 HSD17B12 ATM COPS2 TRIP13 GFM2 ITPR2	8.68e-04	1440	61	9	30833792
Pubmed	Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins.	KCNJ6 KCNJ9	8.84e-04	25	61	2	17185339
Pubmed	Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purification.	DLL4 ARHGEF15	1.19e-03	29	61	2	24003143
Pubmed	Atm deficiency in the DNA polymerase β null cerebellum results in cerebellar ataxia and Itpr1 reduction associated with alteration of cytosine methylation.	ATM ITPR2	1.19e-03	29	61	2	32123907
Pubmed	Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation.	DLL4 CXCR4	1.28e-03	30	61	2	20890042
Pubmed	Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis.	USP30 OTUB1	1.36e-03	31	61	2	25527291
Pubmed	Interactome Analysis of Human Phospholipase D and Phosphatidic Acid-Associated Protein Network.	USP30 MCMBP CD109 GFM2	1.54e-03	282	61	4	35007762
Pubmed	Ubiquitin-specific peptidase 2a (USP2a) deubiquitinates and stabilizes β-catenin.	USP30 OTUB1	1.54e-03	33	61	2	30323974
Pubmed	Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.	SIGMAR1 TIMELESS HTT ITPR2	1.60e-03	285	61	4	32838362
Pubmed	BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.	SETD1A ZBTB33 TRIM24	1.71e-03	134	61	3	25452129
Pubmed	Myocardial Bmp2 gain causes ectopic EMT and promotes cardiomyocyte proliferation and immaturity.	DLL4 CXCR4	1.73e-03	35	61	2	29540665
GeneFamily	Potassium voltage-gated channel subfamily J	KCNJ6 KCNJ9	7.43e-04	16	46	2	276
ToppCell	droplet-Trachea-nan-3m-Endothelial\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYT15 DLL4 INSR TIMELESS S1PR1 ARHGEF15	1.99e-07	184	61	6	fa5c3020e75fdde1363393dea97ebd99f1eae9ff
ToppCell	droplet-Trachea-3m-Endothelial\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SYT15 DLL4 INSR TIMELESS S1PR1 ARHGEF15	1.99e-07	184	61	6	ad520ab6bb776b5303df505b7e1afb22484f18a7
ToppCell	droplet-Trachea-nan-3m-Endothelial-nan\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYT15 DLL4 INSR TIMELESS S1PR1 ARHGEF15	1.99e-07	184	61	6	1d63cb75a89c5f3f3b9ebf7fce8cb0fd4a92b645
ToppCell	droplet-Trachea-nan-3m-Endothelial-endothelial_cell\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYT15 DLL4 INSR TIMELESS S1PR1 ARHGEF15	1.99e-07	184	61	6	76caad53d55fff5acca27bf190a6de7b27437d9f
ToppCell	droplet-Trachea-3m-Endothelial-endothelial_cell_of_trachea\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SYT15 DLL4 INSR TIMELESS S1PR1 ARHGEF15	1.99e-07	184	61	6	1fc1f0a3b4dbb085ebcc3960f67be24a108fe5b9
ToppCell	droplet-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SYT15 DLL4 INSR TIMELESS S1PR1 ARHGEF15	1.99e-07	184	61	6	2467207aaea307873ab286f89cfc7668a227a694
ToppCell	droplet-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l10\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SYT15 DLL4 INSR TIMELESS S1PR1 ARHGEF15	2.33e-07	189	61	6	28b9e96a5206b7fdae9b17daf05c8f5d24b6c5ec
ToppCell	droplet-Lung-immune-endo-depleted-3m-Lymphocytic-Proliferating_NK\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DTNB SLCO4A1 TIMELESS ATM TRIP13	3.75e-06	171	61	5	1eebd7138c3b20ddc1104f21615f9df0e776bbe6
ToppCell	droplet-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l19\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SYT15 DLL4 INSR S1PR1 ARHGEF15	5.08e-06	182	61	5	840427d1c23d60482c943ff006b14007ed44d247
ToppCell	TCGA-Uvea-Primary_Tumor-Uveal_Melanoma-Epithelioid_Cell\|TCGA-Uvea / Sample_Type by Project: Shred V9	DLL4 SRGAP1 TIMELESS ADCY1 ITPR2	5.64e-06	186	61	5	e8580a2093eb7e50aad55ec7fada850d2fed8ae1
ToppCell	droplet-Lung-3m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_aerocyte_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DLL4 PCDHAC1 OCLN S1PR1 ARHGEF15	5.94e-06	188	61	5	db0652f000d459493321b53239326706eace598c
ToppCell	droplet-Kidney-nan-3m-Endothelial-kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYT15 DLL4 TIMELESS S1PR1 ARHGEF15	5.94e-06	188	61	5	67c04f446fa4528b13a381622e88eb1f314cc6d5
ToppCell	droplet-Kidney-nan-3m-Endothelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYT15 DLL4 TIMELESS S1PR1 ARHGEF15	5.94e-06	188	61	5	03a7f6538cfddc230c0eab10c3613929addd7e33
ToppCell	PND07-28-samps-Endothelial\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	DLL4 TIMELESS OCLN S1PR1 ARHGEF15	6.10e-06	189	61	5	eb2f8c8a90e5e9f6697a2d13274c94f40e1973e4
ToppCell	droplet-Mammary_Gland-nan-3m-Endothelial\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DLL4 INSR TIMELESS S1PR1 ARHGEF15	6.10e-06	189	61	5	1d4ad307c0606957dd7bf8da84450e5193cf4a50
ToppCell	droplet-Mammary_Gland-nan-3m-Endothelial-endothelial_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DLL4 INSR TIMELESS S1PR1 ARHGEF15	6.10e-06	189	61	5	b952026044d5f6c0adce60cf24f6e0199e6f8757
ToppCell	droplet-Mammary_Gland-nan-3m-Endothelial-endothelial_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DLL4 INSR TIMELESS S1PR1 ARHGEF15	6.10e-06	189	61	5	25781edbd08c6e413740b796ecc8ba1934bd3aa5
ToppCell	PND07-28-samps-Endothelial-Postnatal_endothelial\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	DLL4 TIMELESS OCLN S1PR1 ARHGEF15	6.10e-06	189	61	5	d4a25d59d88325d3b20f4287e9b1160c82961a96
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DLL4 CXCR4 INSR S1PR1 ARHGEF15	6.58e-06	192	61	5	5a0615fdc217554ccd611504b16e5d97628e207d
ToppCell	COVID-19-kidney-PLVAP+EC\|kidney / Disease (COVID-19 only), tissue and cell type	DLL4 INSR CD109 S1PR1 ARHGEF15	7.10e-06	195	61	5	a436483fec137584611f86b7a498a4dc2aa19cd3
ToppCell	Tracheal-NucSeq-Endothelial-Endothelia_vascular-VE_systemic_arterial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SYT15 DLL4 SLCO4A1 S1PR1 ARHGEF15	7.10e-06	195	61	5	517af3e6784f02c382df6f5691945eefaa9ec4ae
ToppCell	368C-Endothelial_cells-Endothelial-A_(Artery)\|368C / Donor, Lineage, Cell class and subclass (all cells)	DLL4 INSR SLCO4A1 S1PR1 ARHGEF15	7.46e-06	197	61	5	7caa2c86dc4d50b57a7db8f7278d1588282ad6db
ToppCell	Tracheal-NucSeq-Endothelial-Endothelia_vascular-VE_capillary\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DLL4 CD109 SLCO4A1 S1PR1 ARHGEF15	7.46e-06	197	61	5	31bec97c3952c48031bd66a5dad16a70a61519c3
ToppCell	368C-Endothelial_cells-Endothelial-A_(Artery)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	DLL4 INSR SLCO4A1 S1PR1 ARHGEF15	7.46e-06	197	61	5	951f18f326967206adbbfc422cce9eea3d2e0854
ToppCell	Tracheal-NucSeq-Endothelial-Endothelia_vascular\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DLL4 CD109 SLCO4A1 S1PR1 ARHGEF15	7.64e-06	198	61	5	f7aa809040fa9f5782b92eec1f289d690eb5c7bd
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_general_capillary-EC_general_capillary_L.2.0.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DLL4 CD109 SLCO4A1 S1PR1 ARHGEF15	7.64e-06	198	61	5	2400f8b8c51739ea2ae2b9f24f44eaeefa2bb6fc
ToppCell	343B-Endothelial_cells-Endothelial-E-\|343B / Donor, Lineage, Cell class and subclass (all cells)	DLL4 CD109 SLCO4A1 S1PR1 ARHGEF15	7.83e-06	199	61	5	bff61a784ef8bc040f5c7baabccaf7a7cddd5a31
ToppCell	Parenchymal-NucSeq-Endothelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DLL4 CD109 SLCO4A1 S1PR1 ARHGEF15	7.83e-06	199	61	5	a4a9a1c2a34b5a8318a55d1211d6c8661ca9793e
ToppCell	Parenchymal-NucSeq-Endothelial-Endothelia_vascular\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DLL4 CD109 SLCO4A1 S1PR1 ARHGEF15	7.83e-06	199	61	5	d58edc5f74970bb26d844746184e4bae7c494d6b
ToppCell	Tracheal-NucSeq-Endothelial-Endothelia_vascular-VE_pulmonary_venous\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DLL4 SLCO4A1 TIMELESS S1PR1 ARHGEF15	7.83e-06	199	61	5	079931e7196719f22a89cfad82f452ec67219ee5
ToppCell	343B-Endothelial_cells-Endothelial-E\|343B / Donor, Lineage, Cell class and subclass (all cells)	DLL4 CD109 SLCO4A1 S1PR1 ARHGEF15	7.83e-06	199	61	5	3cb1d9d9de64ed0a56c4f8d5e2fa02a13a73d8ac
ToppCell	5'-Parenchyma_lung-Endothelial\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DLL4 CD109 SLCO4A1 S1PR1 ARHGEF15	7.83e-06	199	61	5	c0a1ed48bebcd85cbbffb8ac50fb0f902b97f239
ToppCell	Tracheal-10x3prime_v2-Endothelial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	DLL4 CD109 SLCO4A1 S1PR1 ARHGEF15	8.02e-06	200	61	5	2e51195810bca8a98488a8a06c538feaa27f1f28
ToppCell	Tracheal-10x3prime_v2-Endothelial-Endothelia_vascular\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	DLL4 CD109 SLCO4A1 S1PR1 ARHGEF15	8.02e-06	200	61	5	30dc7ffef2052ee8610cdca952ca12f240bcec50
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	DLL4 CD109 OCLN S1PR1 ARHGEF15	8.02e-06	200	61	5	a1fa6bae5a688faf488d6925cd3fad725dfa916b
ToppCell	Biopsy_Control_(H.)-Endothelial\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	DLL4 CD109 SLCO4A1 S1PR1 ARHGEF15	8.02e-06	200	61	5	6a9b6a4b4f204598290ae21c87ddb42ac95dfc4c
ToppCell	LPS_IL1RA_TNF-Endothelial\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	DLL4 CD109 OCLN S1PR1 ARHGEF15	8.02e-06	200	61	5	d01cec331be3b03cef80e9536fc531285bcf00f6
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_STALK\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	SYT15 DLL4 OCLN CNGB1	4.44e-05	143	61	4	35d3652680c4dddd293301595d813161c66e5673
ToppCell	Adult-Immune-B_cell-D231\|Adult / Lineage, Cell type, age group and donor	CXCR4 KLHL14 GRM4 NIBAN3	7.38e-05	163	61	4	4f5821299b265663c7d0352b28285f56e1988841
ToppCell	10x3'2.3-week_14-16-Lymphocytic_B-B_lineage-immature_B_cell\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	BEST4 KLHL14 NIBAN3 S1PR1	7.55e-05	164	61	4	69b6566fb88c7449b7ab9056b57508cb6a1aa2af
ToppCell	PND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLCO5A1 KLHL14 TRIP13 NIBAN3	7.55e-05	164	61	4	249d8f75a64bce7db52ce0c563f496b9edf602a6
ToppCell	367C-Myeloid-Monocyte-CD16+_Monocyte\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	SLCO5A1 TMEM86B SLCO4A1 KLHL14	7.55e-05	164	61	4	1aff83fc73b4e41e6f0d4b04dbca153bcc7a3518
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DLL4 TMPRSS7 S1PR1 ARHGEF15	7.73e-05	165	61	4	a74751e0ec857aa974bec04ccc747c004a8f6e01
ToppCell	Ionocyte\|World / shred by cell class for turbinate	DLL4 CXCR4 SLCO4A1 ITPR2	7.73e-05	165	61	4	0cb2199b87f17ece743fb2652b2f448dfa78ae0b
ToppCell	367C-Myeloid-Monocyte-CD16+_Monocyte\|367C / Donor, Lineage, Cell class and subclass (all cells)	SLCO5A1 TLR2 TMEM86B KLHL14	7.92e-05	166	61	4	430d604f5bef9fae20dc81492e6695616f6701a3
ToppCell	Control-Lymphocytic_B-B_cells\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLCO5A1 CXCR4 KLHL14 NIBAN3	8.10e-05	167	61	4	a15a70d3837b31cc83a2a9e3f1bbfd77a95f2312
ToppCell	Control-Lymphocytic_B\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLCO5A1 CXCR4 KLHL14 NIBAN3	8.10e-05	167	61	4	956da82394fd6a9f45fc2031796f12cc889542cd
ToppCell	Control-Lymphocytic_B-B_cells-B-cells\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLCO5A1 CXCR4 KLHL14 NIBAN3	8.10e-05	167	61	4	69ed8a4a507190a1a66c4baf1f3e9be21ada39d8
ToppCell	Control-B_cells-Activated_B_cells\|Control / group, cell type (main and fine annotations)	CXCR4 ATM KLHL14 NIBAN3	8.29e-05	168	61	4	a7159a35fe37f8c241cf8d391debe271e0698105
ToppCell	LPS-IL1RA+antiTNF-Lymphocytic_B-B_cells-B-cells\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CXCR4 KLHL14 GRM4 NIBAN3	8.29e-05	168	61	4	eeb381b62c7ba263af96de1194ed59e57b6ca3ae
ToppCell	LPS-IL1RA+antiTNF-Lymphocytic_B-B_cells\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CXCR4 KLHL14 GRM4 NIBAN3	8.29e-05	168	61	4	063d0368d656962b335154c230bdcd9236e7c9ad
ToppCell	LPS-IL1RA+antiTNF-Lymphocytic_B\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CXCR4 KLHL14 GRM4 NIBAN3	8.29e-05	168	61	4	a7c4251d8a83bc30196a444028a35c17c24dc291
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DLL4 CD109 S1PR1 ARHGEF15	8.48e-05	169	61	4	c7fc3a8c44f07c557b60d469717b66e2f5863d38
ToppCell	LPS-IL1RA-Lymphocytic_B-B_cells-B-cells\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CXCR4 KLHL14 GRM4 NIBAN3	8.68e-05	170	61	4	92e0873f618b2fa60c4d555b10f234d5cbcf3325
ToppCell	LPS-IL1RA-Lymphocytic_B-B_cells\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CXCR4 KLHL14 GRM4 NIBAN3	8.68e-05	170	61	4	c181991f933b779f99afc3782f292306f209e2ac
ToppCell	LPS-IL1RA-Lymphocytic_B\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CXCR4 KLHL14 GRM4 NIBAN3	8.68e-05	170	61	4	56284fbfd1e53f67c8c0b7fba64505a4002adba2
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_bronchial_vessel-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CD109 SLCO4A1 ADCY1 ARHGEF15	8.88e-05	171	61	4	1ae4b6a25bc9c1065cf5d95998ebcc70aee21ab5
ToppCell	Adult-Immune-B_cell-D175\|Adult / Lineage, Cell type, age group and donor	NFE2L3 SLCO5A1 KLHL14 NIBAN3	8.88e-05	171	61	4	355a246f3395900342d400f6f7c6640cba0d4d5d
ToppCell	E12.5-Endothelial-proliferative_endothelial_cell-proliferative_endothelial_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	DLL4 CD109 S1PR1 ARHGEF15	9.08e-05	172	61	4	ba99688e9f46671deccf824b1e77c6db0742d7df
ToppCell	E12.5-Endothelial-proliferative_endothelial_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	DLL4 CD109 S1PR1 ARHGEF15	9.08e-05	172	61	4	2136170f6e1204734cec7dbf7b32e7d5179b92b5
ToppCell	control-Lymphocytic-B_cells_2\|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	CXCR4 OPN3 KLHL14 NIBAN3	9.29e-05	173	61	4	95af11b7d6c7dcd470943e5bdc56bed7a134e358
ToppCell	LPS-antiTNF-Lymphocytic_B\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CXCR4 KLHL14 GRM4 NIBAN3	9.50e-05	174	61	4	cc493654ea3517bc6a145c7f787f304929636f86
ToppCell	LPS-antiTNF-Lymphocytic_B-B_cells-B-cells\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CXCR4 KLHL14 GRM4 NIBAN3	9.50e-05	174	61	4	9eb3504f9340517ef5d056503044fbdb9ffeb714
ToppCell	LPS-antiTNF-Lymphocytic_B-B_cells\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CXCR4 KLHL14 GRM4 NIBAN3	9.50e-05	174	61	4	b4c2d1c029fcd0d4926aa79a5b789c713919dcf3
ToppCell	5'-GW_trimst-2-LymphNode-Endothelial-blood_vessel_EC-Fetal_venous_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CD109 ADCY1 S1PR1 ARHGEF15	9.50e-05	174	61	4	6b5ff1cc5fe6705f7ea70b5a892dfbf91e32288d
ToppCell	368C-Endothelial_cells-Endothelial-D\|368C / Donor, Lineage, Cell class and subclass (all cells)	DLL4 SLCO4A1 S1PR1 ARHGEF15	9.71e-05	175	61	4	c4088b5f9fa145869cf5dd8bee7680b1c8fada42
ToppCell	368C-Endothelial_cells-Endothelial-D-\|368C / Donor, Lineage, Cell class and subclass (all cells)	DLL4 SLCO4A1 S1PR1 ARHGEF15	9.71e-05	175	61	4	ca0d3e3a0a271cccdd3881b055fecb626712478d
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Gkn3_(Gkn3)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	SYT15 DLL4 CNGB1	9.76e-05	65	61	3	c736a773a1b9cb16b51849a3bf0ccd9aeec7b342
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Gkn3_(Gkn3)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	SYT15 DLL4 CNGB1	9.76e-05	65	61	3	8f7eac868f1605830cc97d9d1676f3ebff47d49b
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Gkn3_(Gkn3)--\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	SYT15 DLL4 CNGB1	9.76e-05	65	61	3	350f33bcc5924d7e3c3318391d33a984763fe206
ToppCell	Adult-Immune-B_cell\|Adult / Lineage, Cell type, age group and donor	SLCO5A1 CXCR4 KLHL14 NIBAN3	9.92e-05	176	61	4	4aa00dcde907ad83d3aa4bb10439b7b5c4be1e5d
ToppCell	facs-Pancreas-Endocrine-18m-Endothelial-endothelial_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DLL4 TIMELESS S1PR1 ARHGEF15	9.92e-05	176	61	4	9ddf87e586d2378984cd007c60f7dc254845f8f3
ToppCell	facs-Pancreas-Endocrine-18m-Endothelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DLL4 TIMELESS S1PR1 ARHGEF15	9.92e-05	176	61	4	e987e741fcf1bed8598a5060700efd3018f8123b
ToppCell	Control-B_cells\|Control / group, cell type (main and fine annotations)	CXCR4 ATM KLHL14 NIBAN3	9.92e-05	176	61	4	9125caa27bf790f6b1b960a86c09b4bcb1b58641
ToppCell	Control-B_cells-B_cells\|Control / group, cell type (main and fine annotations)	CXCR4 ATM KLHL14 NIBAN3	9.92e-05	176	61	4	d2c353783bd78dc24f28e00d917b88d8294fb5df
ToppCell	facs-Pancreas-Endocrine-18m-Endothelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DLL4 TIMELESS S1PR1 ARHGEF15	9.92e-05	176	61	4	92ebcea9b2b22601234b76d7a98f0410b905a87b
ToppCell	droplet-Liver-LIVER_HEP-30m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NFE2L3 TLR2 CD109 CNGB1	9.92e-05	176	61	4	5e46a09a36b9645b1b1fcb0b64bd0898561af3a9
ToppCell	LPS_only-Lymphocytic_B-B_cells\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CXCR4 KLHL14 GRM4 NIBAN3	1.01e-04	177	61	4	c82332c5f656aa26513e4f7525d5d4d733019725
ToppCell	LPS_only-Lymphocytic_B\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CXCR4 KLHL14 GRM4 NIBAN3	1.01e-04	177	61	4	5ed65e08d773d157840317c72e0d43c261d438d4
ToppCell	LPS_only-Lymphocytic_B-B_cells-B-cells\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CXCR4 KLHL14 GRM4 NIBAN3	1.01e-04	177	61	4	8a955a7ab84c434f9ad4b467246b8be3cb479406
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SRGAP1 TIMELESS S1PR1 ARHGEF15	1.01e-04	177	61	4	0e74980a7686c31fcf1476b8f19a3392541df240
ToppCell	5'-GW_trimst-2-LargeIntestine-Hematopoietic-B_cells-Immature_B\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CXCR4 SLCO4A1 KLHL14 NIBAN3	1.04e-04	178	61	4	2e51c1596022b7047994ee13c18375bad19a54a5
ToppCell	droplet-Heart-4Chambers-18m-Endothelial-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLCO4A1 CNGB1 S1PR1 ARHGEF15	1.04e-04	178	61	4	ba2f0585626988b511046630bc16be5c5fec3fb2
ToppCell	droplet-Heart-4Chambers-18m-Endothelial-endothelial_cell_of_coronary_artery\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLCO4A1 CNGB1 S1PR1 ARHGEF15	1.04e-04	178	61	4	93ce73f8bcec63ebf86fabb546f88400e8f06465
ToppCell	COVID-19-kidney-PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DLL4 INSR CD109 ARHGEF15	1.08e-04	180	61	4	493cf8d1a8f2a1ed2672f394a0338b110fd81d88
ToppCell	367C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)\|367C / Donor, Lineage, Cell class and subclass (all cells)	DLL4 SLCO4A1 OCLN S1PR1	1.08e-04	180	61	4	162cec1734e560c068cd61717e40e18dcf92308c
ToppCell	Endothelial-A-HP_01\|World / lung cells shred on cell class, cell subclass, sample id	KCNJ9 SLCO4A1 S1PR1 ARHGEF15	1.08e-04	180	61	4	4c3376169770ee9f9283daae44c17f35e46bfd19
ToppCell	367C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	DLL4 SLCO4A1 OCLN S1PR1	1.08e-04	180	61	4	33c86c22ba877358cd8c1e39b5c0b3dc3a45b7dd
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SYT15 DLL4 CXCR4 ARHGEF15	1.11e-04	181	61	4	4d7793026373cbcf04b15c77f95f1025d07d4c00
ToppCell	droplet-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SYT15 ZFP28 TRIP13 S1PR1	1.11e-04	181	61	4	2c44c41b4e8a75ebdbaeb0c6cc5a03f17c44758c
ToppCell	droplet-Heart-nan-3m-Endothelial-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DLL4 S1PR1 ARHGEF15 ITPR2	1.11e-04	181	61	4	92d44892bb15771f0ab5fe61879b204b0acbd9b3
ToppCell	droplet-Mammary_Gland-nan-18m-Endothelial-nan\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYT15 DLL4 S1PR1 ARHGEF15	1.11e-04	181	61	4	2e15c46e8260bb04d8264478c19a707221996026
ToppCell	10x3'2.3-week_14-16-Endothelial-stroma-proliferating_EC\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	DLL4 SRGAP1 S1PR1 ARHGEF15	1.13e-04	182	61	4	997d37ca2af661c92a56add888762724dfccc890
ToppCell	droplet-Heart-nan-3m-Endothelial-endothelial_cell_of_coronary_artery\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DLL4 S1PR1 ARHGEF15 ITPR2	1.13e-04	182	61	4	81279877b920b5a1bc991a07d3031d6458700fe3
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SYT15 DLL4 CXCR4 ARHGEF15	1.15e-04	183	61	4	3427f3cbe6ea81709750e7dd3ff378f03ae65eab
ToppCell	droplet-Kidney-nan-18m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLCO4A1 KLHL14 OCLN ADCY1	1.15e-04	183	61	4	03c7e69136d5a3b9c5b2c91733e9b1c791f45c49
ToppCell	(4)_Endothelial_cells-(40)_EC-arterial\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	SYT15 CNGB1 S1PR1 ARHGEF15	1.18e-04	184	61	4	7e1a2971321ddcfa00d78d3e3ba7960e532f9392
ToppCell	PCW_10-12-Endothelial-Endothelial_mature-endo_arterial_(9)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	DLL4 CXCR4 ADCY1 ARHGEF15	1.18e-04	184	61	4	a809b0fa52df8a159f60f87eefcef61220af5e34
ToppCell	droplet-Heart-4Chambers-21m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DLL4 OCLN S1PR1 ARHGEF15	1.18e-04	184	61	4	f17d713af4a97dff4eeeab24c405677ef2ffcf84
ToppCell	facs-Trachea-nan-24m-Endothelial\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DLL4 CNGB1 S1PR1 ARHGEF15	1.20e-04	185	61	4	dec60254204014083ff3b4aec0cc75410950a486
Computational	Neighborhood of LTK	GPR3 ATM GRM4 HTT	1.95e-05	46	38	4	GCM_LTK
Computational	Neighborhood of RING1	GPR3 SIGMAR1 GRM4 TRIP13 HTT	4.28e-05	112	38	5	GCM_RING1
Computational	Neighborhood of FANCC	GPR3 SIGMAR1 GABRQ GRM4 TRIP13	7.52e-05	126	38	5	GCM_FANCC
Drug	Loperamide hydrochloride [34552-83-5]; Up 200; 7.8uM; PC3; HT_HG-U133A	SETD1A MGAM CXCR4 TLR2 INSR SI	1.15e-05	189	61	6	4672_UP
Drug	baclofen	SIGMAR1 KCNJ6 KCNJ9 GABRQ GRM4 ADCY1	1.22e-05	191	61	6	CID000002284
Drug	Revivon	SIGMAR1 KCNJ6 KCNJ9 ADCY1	1.33e-05	54	61	4	CID000026644
Drug	Norgestrel-(-)-D [797-63-7]; Down 200; 12.8uM; PC3; HT_HG-U133A	SETD1A CXCR4 TLR2 TIMELESS ATM BBS9	1.45e-05	197	61	6	3708_DN
Drug	Ribavirin [36791-04-5]; Down 200; 16.4uM; MCF7; HT_HG-U133A	GPR3 ZBTB33 INSR ATM BBS9 ITPR2	1.45e-05	197	61	6	6018_DN
Drug	Proguanil hydrochloride [637-32-1]; Up 200; 13.8uM; MCF7; HT_HG-U133A	GPR3 ZBTB33 DTNB ATM GRM4 SLC22A7	1.50e-05	198	61	6	3505_UP
Drug	arcaine	SIGMAR1 DTNB GABRQ	1.72e-05	19	61	3	CID000002227
Drug	Copper silicide	MGAM SI	2.11e-05	3	61	2	CID006336988
Drug	Acarbose	MGAM SI	4.22e-05	4	61	2	DB00284
Drug	nimbidiol	MGAM SI	4.22e-05	4	61	2	ctd:C496111
Disease	hemangioblastoma (is_marker_for)	DLL4 CXCR4	2.19e-05	4	57	2	DOID:5241 (is_marker_for)
Disease	1,5 anhydroglucitol measurement	MGAM PCDHAC1 SI	2.41e-05	29	57	3	EFO_0008009
Disease	renal cell carcinoma	INSR ATM ITPR2	7.44e-05	42	57	3	EFO_0000681
Disease	Prenatal Exposure Delayed Effects	SIGMAR1 ATM	2.39e-04	12	57	2	C0033054
Disease	lymphocyte count	NFE2L3 CXCR4 OPN3 ATM KLHL14 NIBAN3 S1PR1 ARHGEF15 HTT ITPR2	4.49e-04	1464	57	10	EFO_0004587
Disease	pre-malignant neoplasm (biomarker_via_orthology)	INSR ATM	4.89e-04	17	57	2	DOID:0060071 (biomarker_via_orthology)
Disease	atopic dermatitis (is_implicated_in)	TLR2 SHOC2	1.16e-03	26	57	2	DOID:3310 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
ALYAVLSITYRLLLT	BEST4	41	Q8NFU0
LSITYRLLLTQEQRY	BEST4	46	Q8NFU0
YSSVLILAFISLDRY	CXCR4	121	P61073
RYKQLLTYIRSAVTR	COPS2	91	P61201
SYAALLTKTNRIYRI	GRM4	666	Q14833
TSTLTRLRYSYRVIC	DLL4	161	Q9NR61
SYLRSLRLLTDTFVL	ARHGEF15	431	O94989
LSSRYLEVLINLYRT	RBM43	316	Q6ZSC3
SRTRRYYLSVIIVSA	OCLN	166	Q16625
FYSFSELLRLTRTLL	ITPR2	876	Q14571
TYRYLTDLFTTLVDL	KCNJ9	41	Q92806
GYTLLTSQREYLRLL	NIBAN3	151	Q86XR2
NITELRRIYSFYSSL	RSPH10B	416	P0C881
NITELRRIYSFYSSL	RSPH10B2	416	B2RC85
SSYIFIIASILRIRY	OR8G5	251	Q8NG78
ILNYIYSSKIVRVRS	ZBTB33	81	Q86T24
TYLAVLYDSTRISLF	MTMR10	486	Q9NXD2
RETYRYLTDIFTTLV	KCNJ6	71	P48051
DSRLAYYETTLNLTL	GABRQ	116	Q9UN88
SRTVLQTRYTLLPYL	MGAM	2501	O43451
LYRVTCDQTYLLRSL	LANCL2	116	Q9NS86
LSYSYIVRAVLQIRS	OR2W3	216	Q7Z3T1
LSRYYLTDLQVSLIR	NFE2L3	566	Q9Y4A8
SYILILYSVLRLNSA	OR56B1	226	Q8NGI3
SVYLYLSSLRESCTI	LIPH	251	Q8WWY8
DQLRLITSLVYLYSR	MSLNL	371	Q96KJ4
ISGYLKIRRSYALVS	INSR	391	P06213
YTYIIRTILRIPSAQ	OR6C4	216	Q8NGE1
SLLAITVDRYLSLYN	GPR3	126	P46089
LTRTVSFSVYLKRSY	BBS9	481	Q3SYG4
LTIRLSSRYRYGQLI	TRIP13	196	Q15645
TVERLSQTYLYRASL	PCDHAC1	746	Q9H158
IVSIATLTVLAYERY	OPN3	126	Q9H1Y3
STSDYLVVYLRLLTS	OTUB1	166	Q96FW1
YSLTLDRTLAIVYSV	OR6N2	266	Q8NGY6
RSLESVYSLYPTLSR	ATM	2161	Q13315
TSYILVLELSGYTRT	ADCY1	761	Q08828
VTLTAYIVTSLLGYR	CD109	1046	Q6YHK3
SVSTITRIYRGYNLL	HTT	976	P42858
RLVLEYLYTANVTLS	KLHL14	136	Q9P2G3
YLALRISYSLFTALR	HSD17B12	21	Q53GQ0
ISVSRLETVISSIYY	DTNB	76	O60941
LLVYLSVRYAGRRLT	SLC22A7	391	Q9Y694
SIVILYCRIYSLVRT	S1PR1	216	P21453
AEYLILHLISTVYTR	MCMBP	366	Q9BTE3
LSYNDYLSRLTVVVL	SYT15	286	Q9BQS2
TTERILYYSGYTRSL	GFM2	86	Q969S9
LRTYLSAEYNLETSR	SRGAP1	281	Q7Z6B7
YTLRSYARGLRLELT	SIGMAR1	201	Q99720
SGYLSSVITTIERRY	SLCO5A1	146	Q9H2Y9
SVVYRLDSLTTLYLR	SHOC2	186	Q9UQ13
LVKSSRQYLTIRYTL	SI	681	P14410
SYLRLTYERLLQQTS	SETD1A	1441	O15047
TVITSLERRYDLHSY	SLCO4A1	126	Q96BD0
SILSKAYVYRVIRTT	CNGB1	781	Q14028
STVVRAYVLLLRSYQ	TIMELESS	701	Q9UNS1
ITERLTSYNLEYSLL	ZFP28	201	Q8NHY6
SSTALLYSKRLITYR	TRIM24	371	O15164
IYDSLLPIRSSILYR	TMPRSS7	306	Q7RTY8
YYAAQLLITLSALRS	TMEM86B	206	Q8N661
SSSAYLLFYERVLSR	USP30	491	Q70CQ3
YDLSTLYSLTERVKR	TLR2	326	O60603