Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	zinc ion binding	ANKIB1 NFXL1 EHMT1 CUL9 KDM2A RNF144A TUT7 ZNF185	4.10e-06	891	23	8	GO:0008270
GeneOntologyMolecularFunction	transition metal ion binding	ANKIB1 NFXL1 EHMT1 CUL9 KDM2A RNF144A TUT7 ZNF185	3.38e-05	1189	23	8	GO:0046914
GeneOntologyMolecularFunction	ubiquitin conjugating enzyme binding	ANKIB1 RNF144A	7.81e-04	36	23	2	GO:0031624
GeneOntologyMolecularFunction	ubiquitin-like protein conjugating enzyme binding	ANKIB1 RNF144A	1.06e-03	42	23	2	GO:0044390
GeneOntologyMolecularFunction	histone H3 methyltransferase activity	EHMT1 KMT2C	1.17e-03	44	23	2	GO:0140938
GeneOntologyMolecularFunction	histone modifying activity	EHMT1 KMT2C KDM2A	2.23e-03	229	23	3	GO:0140993
GeneOntologyMolecularFunction	protein-lysine N-methyltransferase activity	EHMT1 KMT2C	2.76e-03	68	23	2	GO:0016279
GeneOntologyMolecularFunction	lysine N-methyltransferase activity	EHMT1 KMT2C	2.84e-03	69	23	2	GO:0016278
GeneOntologyMolecularFunction	histone methyltransferase activity	EHMT1 KMT2C	3.01e-03	71	23	2	GO:0042054
GeneOntologyCellularComponent	megasporocyte nucleus	ZNF70 ZFP64	1.16e-06	2	23	2	GO:0043076
GeneOntologyCellularComponent	ubiquitin ligase complex	ANKIB1 CCNF CUL9 RNF144A	5.43e-04	352	23	4	GO:0000151
HumanPheno	Moderate receptive language delay	EHMT1 KMT2C	6.47e-06	3	8	2	HP:0011351
HumanPheno	Large for gestational age	EHMT1 KMT2C RYR1	5.42e-05	52	8	3	HP:0001520
HumanPheno	Severe expressive language delay	EHMT1 KMT2C	1.41e-04	12	8	2	HP:0006863
HumanPheno	Receptive language delay	EHMT1 KMT2C	2.24e-04	15	8	2	HP:0010863
HumanPheno	Overgrowth	EHMT1 KMT2C RYR1	2.53e-04	87	8	3	HP:0001548
MousePheno	abnormal limb morphology	ANKIB1 CCNF NFXL1 PDZD8 RYR1 PDLIM4 DKK1	7.22e-05	1028	16	7	MP:0002109
MousePheno	short tibia	ANKIB1 NFXL1 PDZD8 PDLIM4	2.18e-04	274	16	4	MP:0002764
MousePheno	limbs/digits/tail phenotype	ANKIB1 CCNF NFXL1 PDZD8 RYR1 PDLIM4 DKK1	2.60e-04	1258	16	7	MP:0005371
MousePheno	decreased midbrain size	CCNF DKK1	3.06e-04	23	16	2	MP:0012089
MousePheno	abnormal hindlimb morphology	ANKIB1 NFXL1 PDZD8 PDLIM4 DKK1	3.49e-04	576	16	5	MP:0000556
Domain	IBR	ANKIB1 CUL9 RNF144A	5.89e-07	14	23	3	PF01485
Domain	IBR	ANKIB1 CUL9 RNF144A	5.89e-07	14	23	3	SM00647
Domain	IBR_dom	ANKIB1 CUL9 RNF144A	7.35e-07	15	23	3	IPR002867
Domain	ZF_RING_2	ANKIB1 NFXL1 CUL9 KMT2C RNF144A	2.66e-05	298	23	5	PS50089
Domain	ZINC_FINGER_C2H2_1	ZNF70 ZNF532 ZNF578 ZNF223 ZFP64 TUT7 ZNF124	2.87e-05	777	23	7	PS00028
Domain	Znf_C2H2	ZNF70 ZNF532 ZNF578 ZNF223 ZFP64 TUT7 ZNF124	3.60e-05	805	23	7	IPR007087
Domain	Znf_RING	ANKIB1 NFXL1 CUL9 KMT2C RNF144A	4.08e-05	326	23	5	IPR001841
Domain	E3_UB_ligase_RBR	ANKIB1 RNF144A	6.49e-05	10	23	2	IPR031127
Domain	-	ZNF70 ZNF532 ZNF578 ZNF223 ZFP64 ZNF124	1.34e-04	679	23	6	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZNF70 ZNF532 ZNF578 ZNF223 ZFP64 ZNF124	1.51e-04	694	23	6	IPR013087
Domain	ZINC_FINGER_C2H2_2	ZNF70 ZNF532 ZNF578 ZNF223 ZFP64 ZNF124	2.76e-04	775	23	6	PS50157
Domain	Znf_C2H2-like	ZNF70 ZNF532 ZNF578 ZNF223 ZFP64 ZNF124	3.18e-04	796	23	6	IPR015880
Domain	ZnF_C2H2	ZNF70 ZNF532 ZNF578 ZNF223 ZFP64 ZNF124	3.45e-04	808	23	6	SM00355
Domain	ZF_RING_1	ANKIB1 NFXL1 CUL9 RNF144A	4.05e-04	291	23	4	PS00518
Domain	RING	ANKIB1 CUL9 KMT2C RNF144A	4.83e-04	305	23	4	SM00184
Domain	Znf_FYVE_PHD	ANKIB1 KMT2C KDM2A	7.54e-04	147	23	3	IPR011011
Domain	SET	EHMT1 KMT2C	1.16e-03	41	23	2	PF00856
Domain	zf-C2H2	ZNF70 ZNF578 ZNF223 ZFP64 ZNF124	1.34e-03	693	23	5	PF00096
Domain	SET	EHMT1 KMT2C	1.45e-03	46	23	2	SM00317
Domain	SET_dom	EHMT1 KMT2C	1.71e-03	50	23	2	IPR001214
Domain	SET	EHMT1 KMT2C	1.71e-03	50	23	2	PS50280
Domain	FBOX	CCNF KDM2A	1.85e-03	52	23	2	SM00256
Domain	Ank	ANKIB1 EHMT1 TRPC3	2.65e-03	228	23	3	PF00023
Domain	Zinc_finger_PHD-type_CS	NFXL1 KDM2A	2.88e-03	65	23	2	IPR019786
Domain	C1	PDZD8 KMT2C	2.88e-03	65	23	2	SM00109
Domain	PE/DAG-bd	PDZD8 KMT2C	2.97e-03	66	23	2	IPR002219
Domain	F-box	CCNF KDM2A	3.06e-03	67	23	2	PF00646
Domain	-	ZNF185 PDLIM4	3.33e-03	70	23	2	2.10.110.10
Domain	-	ANKIB1 EHMT1 TRPC3	3.37e-03	248	23	3	1.25.40.20
Domain	LIM_DOMAIN_2	ZNF185 PDLIM4	3.42e-03	71	23	2	PS50023
Domain	Znf_LIM	ZNF185 PDLIM4	3.42e-03	71	23	2	IPR001781
Domain	LIM_DOMAIN_1	ZNF185 PDLIM4	3.42e-03	71	23	2	PS00478
Domain	LIM	ZNF185 PDLIM4	3.42e-03	71	23	2	SM00132
Domain	ANK	ANKIB1 EHMT1 TRPC3	3.48e-03	251	23	3	SM00248
Domain	FBOX	CCNF KDM2A	3.52e-03	72	23	2	PS50181
Domain	ANK_REPEAT	ANKIB1 EHMT1 TRPC3	3.56e-03	253	23	3	PS50088
Domain	Ankyrin_rpt-contain_dom	ANKIB1 EHMT1 TRPC3	3.60e-03	254	23	3	IPR020683
Domain	ANK_REP_REGION	ANKIB1 EHMT1 TRPC3	3.60e-03	254	23	3	PS50297
Domain	F-box_dom	CCNF KDM2A	3.81e-03	75	23	2	IPR001810
Domain	Ankyrin_rpt	ANKIB1 EHMT1 TRPC3	3.93e-03	262	23	3	IPR002110
Domain	Znf_PHD-finger	KMT2C KDM2A	4.22e-03	79	23	2	IPR019787
Domain	PHD	KMT2C KDM2A	5.32e-03	89	23	2	SM00249
Domain	Znf_PHD	KMT2C KDM2A	5.56e-03	91	23	2	IPR001965
Domain	ZF_PHD_2	KMT2C KDM2A	6.04e-03	95	23	2	PS50016
Domain	ZF_PHD_1	KMT2C KDM2A	6.17e-03	96	23	2	PS01359
Domain	zf-C2H2_6	ZNF532 ZNF578 ZFP64	6.50e-03	314	23	3	PF13912
Domain	Ion_trans_dom	RYR1 TRPC3	8.59e-03	114	23	2	IPR005821
Domain	Ion_trans	RYR1 TRPC3	8.59e-03	114	23	2	PF00520
Domain	KRAB	ZNF578 ZNF223 ZNF124	9.31e-03	358	23	3	PS50805
Domain	KRAB	ZNF578 ZNF223 ZNF124	9.31e-03	358	23	3	PF01352
Pubmed	TRPC3-interacting triadic proteins in skeletal muscle.	RYR1 TRPC3	4.18e-07	2	23	2	18215135
Pubmed	Functional convergence of histone methyltransferases EHMT1 and KMT2C involved in intellectual disability and autism spectrum disorder.	EHMT1 KMT2C	4.18e-07	2	23	2	29069077
Pubmed	Functional coupling between TRPC3 and RyR1 regulates the expressions of key triadic proteins.	RYR1 TRPC3	4.18e-07	2	23	2	16484216
Pubmed	Disruption of an EHMT1-associated chromatin-modification module causes intellectual disability.	EHMT1 KMT2C	4.18e-07	2	23	2	22726846
Pubmed	Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.	EHMT1 KMT2C KDM2A	4.56e-06	49	23	3	34368113
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	ZNF532 KMT2C ZFP64 TUT7 ZNF185 PDLIM4	5.28e-06	709	23	6	22988430
Pubmed	New nomenclature for chromatin-modifying enzymes.	EHMT1 KMT2C KDM2A	7.22e-06	57	23	3	18022353
Pubmed	ZNF70, a novel ILDR2-interacting protein, contributes to the regulation of HES1 gene expression.	ZNF70 ZFP64	1.88e-05	10	23	2	27353377
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	ANKIB1 EHMT1 ZNF532 KMT2C KDM2A RNF144A ZFP64	3.48e-05	1489	23	7	28611215
Pubmed	Cyclin F-Mediated Degradation of SLBP Limits H2A.X Accumulation and Apoptosis upon Genotoxic Stress in G2.	CCNF TUT7	4.99e-05	16	23	2	27773672
Pubmed	Dynamic regulation of sarcoplasmic reticulum Ca(2+) stores by stromal interaction molecule 1 and sarcolipin during muscle differentiation.	RYR1 TRPC3	5.66e-05	17	23	2	22411552
Pubmed	Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.	KMT2C KDM2A	8.72e-05	21	23	2	27626377
Pubmed	Isolation and characterization of proteins associated with histone H3 tails in vivo.	EHMT1 KMT2C	1.80e-04	30	23	2	17403666
Pubmed	MLL4 is required after implantation, whereas MLL3 becomes essential during late gestation.	KMT2C DKK1	2.18e-04	33	23	2	32439762
Pubmed	Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes.	EHMT1 KDM2A	2.32e-04	34	23	2	30894540
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	RYR1 TRPC3	2.90e-04	38	23	2	30786075
Pubmed	Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice.	EHMT1 RYR1	3.05e-04	39	23	2	24703692
Pubmed	A GO catalogue of human DNA-binding transcription factors.	ZNF532 ZNF223	3.54e-04	42	23	2	34673265
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ANKIB1 EHMT1 ZNF532 KMT2C	3.72e-04	529	23	4	14621295
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	EHMT1 KMT2C KDM2A	4.30e-04	225	23	3	12168954
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF70 ZNF532 ZNF578 ZNF223 ZFP64 ZNF124	9.23e-05	718	20	6	28
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	EHMT1 KMT2C	6.38e-04	34	20	2	487
GeneFamily	LIM domain containing	ZNF185 PDLIM4	1.92e-03	59	20	2	1218
GeneFamily	PHD finger proteins	KMT2C KDM2A	4.39e-03	90	20	2	88
GeneFamily	PDZ domain containing	PDZD8 PDLIM4	1.21e-02	152	20	2	1220
GeneFamily	Ankyrin repeat domain containing	ANKIB1 EHMT1	2.89e-02	242	20	2	403
Coexpression	GSE46242_TH1_VS_ANERGIC_TH1_CD4_TCELL_DN	NFXL1 ZNF532 CUL9 RYR1	2.26e-05	193	23	4	M9712
Computational	Ion channels.	RYR1 TRPC3	4.66e-04	27	13	2	MODULE_214
Disease	response to triptolide, cytotoxicity measurement	ZNF532 LRRC3B	6.93e-05	16	23	2	EFO_0006952, EFO_0007662
Disease	Malignant neoplasm of breast	EHMT1 ZNF532 LRRC3B ZFP64 DKK1	1.23e-03	1074	23	5	C0006142
Disease	lung non-small cell carcinoma (is_implicated_in)	KMT2C KDM2A	5.22e-03	139	23	2	DOID:3908 (is_implicated_in)
Disease	alcohol dependence	ZNF532 ZNF124	8.88e-03	183	23	2	MONDO_0007079

Protein segments in the cluster

Peptide	Gene	Start	Entry
CAFGLCCKDCKFMPS	ADAM21	446	Q9UKJ8
GCNHMQCAKCKYDFC	ANKIB1	531	Q9P2G1
KCCEEKCTQMYHYPC	KMT2C	296	Q8NEZ4
CSGCFCIFHMPCIQK	NFXL1	176	Q6ZNB6
ASQCMFCAYVCHKKC	PDZD8	866	Q8NEN9
LCFHSASMCPKGCLC	LRRC3B	26	Q96PB8
MMCKNCKHAFCWYCL	RNF144A	201	P50876
ECGVCHYCRDMKKFG	KDM2A	581	Q9Y2K7
VVHCRCAKCFCYPTK	CCNF	6	P41002
DDLPSLCCMHYCCKS	CUL9	2081	Q8IWT3
CMRHAMCCPGNYCKN	DKK1	121	O94907
PKMVTSCCRFLCYFC	RYR1	2226	P21817
RMVKHQCCPGCGYFC	EHMT1	581	Q9H9B1
DKLYHPECFMCSDCG	PDLIM4	271	P50479
CEVFYKCPICPMAFK	ZNF532	866	Q9HCE3
CKVCDKAFMCHSYLA	ZNF578	541	Q96N58
CKLHMGEKHYNCEAC	ZNF223	251	Q9UK11
EKPYVCMECGKAFSC	ZNF124	231	Q15973
EKPYECCQCGKAFCH	ZNF70	361	Q9UC06
CCRICGKIGHFMKDC	TUT7	1346	Q5VYS8
CCYPGCHFKTVHGMK	ZFP64	301	Q9NTW7
CHEYCFKCGICSKPM	ZNF185	651	O15231
RPHDYFCKCGDCMEK	TRPC3	176	Q13507