Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcesspattern recognition receptor signaling pathway

TAX1BP1 TNIP1

1.97e-0329452GO:0002221
GeneOntologyBiologicalProcessinnate immune response-activating signaling pathway

TAX1BP1 TNIP1

2.21e-0331252GO:0002758
GeneOntologyBiologicalProcessactivation of innate immune response

TAX1BP1 TNIP1

2.52e-0333352GO:0002218
GeneOntologyBiologicalProcesspositive regulation of innate immune response

TAX1BP1 TNIP1

3.97e-0342052GO:0045089
GeneOntologyBiologicalProcesspositive regulation of response to biotic stimulus

TAX1BP1 TNIP1

4.57e-0345152GO:0002833
GeneOntologyBiologicalProcessregulation of innate immune response

TAX1BP1 TNIP1

6.01e-0351952GO:0045088
GeneOntologyBiologicalProcessimmune response-activating signaling pathway

TAX1BP1 TNIP1

6.80e-0355352GO:0002757
GeneOntologyBiologicalProcesspositive regulation of defense response

TAX1BP1 TNIP1

7.69e-0358952GO:0031349
GeneOntologyBiologicalProcessimmune response-regulating signaling pathway

TAX1BP1 TNIP1

8.36e-0361552GO:0002764
GeneOntologyBiologicalProcessactivation of immune response

TAX1BP1 TNIP1

8.57e-0362352GO:0002253
GeneOntologyBiologicalProcessregulation of response to biotic stimulus

TAX1BP1 TNIP1

9.11e-0364352GO:0002831
DomainZnf_C2H2-like

TAX1BP1 ZNF646

1.66e-0279652IPR015880
DomainZnf_C2H2

TAX1BP1 ZNF646

1.70e-0280552IPR007087
DomainZnF_C2H2

TAX1BP1 ZNF646

1.71e-0280852SM00355
Pubmed

Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions.

TAX1BP1 TNIP1

1.65e-0755211389905
Pubmed

ABIN1 protein cooperates with TAX1BP1 and A20 proteins to inhibit antiviral signaling.

TAX1BP1 TNIP1

2.48e-0765221885437
Pubmed

A20 is a potent inhibitor of TLR3- and Sendai virus-induced activation of NF-kappaB and ISRE and IFN-beta promoter.

TAX1BP1 TNIP1

3.47e-0775215474016
Pubmed

Identification of polyubiquitin binding proteins involved in NF-kappaB signaling using protein arrays.

TAX1BP1 TNIP1

8.19e-06325219285159
Pubmed

ANKRD13a controls early cell-death checkpoint by interacting with RIP1 independent of NF-κB.

TAX1BP1 TNIP1

1.56e-05445234839354
Pubmed

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.

TAX1BP1 HIF1AN TNIP1 ZNF646

1.57e-0514775431515488
Pubmed

TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1.

TAX1BP1 TNIP1

1.11e-041175236898370
InteractionKATNAL2 interactions

HIF1AN TNIP1

1.86e-052852int:KATNAL2
InteractionTNIP3 interactions

TAX1BP1 TNIP1

2.75e-053452int:TNIP3
InteractionAZI2 interactions

TAX1BP1 HIF1AN

3.83e-054052int:AZI2
InteractionC11orf98 interactions

TAX1BP1 TNIP1

4.64e-054452int:C11orf98
InteractionPCLAF interactions

TAX1BP1 TNIP1

6.75e-055352int:PCLAF
InteractionTBK1 interactions

TAX1BP1 HIF1AN TNIP1

7.65e-0540253int:TBK1
InteractionNOTCH2 interactions

TAX1BP1 HIF1AN ZNF646

8.90e-0542353int:NOTCH2
InteractionNSUN5 interactions

TAX1BP1 TNIP1

8.96e-056152int:NSUN5
InteractionPPP1R12B interactions

HIF1AN TNIP1

1.11e-046852int:PPP1R12B
InteractionOTUD7B interactions

TAX1BP1 HIF1AN

1.25e-047252int:OTUD7B
InteractionPLEKHB2 interactions

TAX1BP1 TNIP1

1.25e-047252int:PLEKHB2
InteractionMAP1LC3C interactions

TAX1BP1 TNIP1

1.25e-047252int:MAP1LC3C
InteractionLITAF interactions

TAX1BP1 TNIP1

1.43e-047752int:LITAF
InteractionCNN2 interactions

TAX1BP1 HIF1AN

1.54e-048052int:CNN2
InteractionMAZ interactions

TAX1BP1 TNIP1

1.78e-048652int:MAZ
InteractionAPEH interactions

TAX1BP1 TNIP1

1.83e-048752int:APEH
InteractionPPIL2 interactions

HIF1AN TNIP1

1.83e-048752int:PPIL2
InteractionCCT8 interactions

TAX1BP1 HIF1AN TNIP1

1.94e-0455053int:CCT8
InteractionRP9 interactions

TAX1BP1 TNIP1

2.37e-049952int:RP9
InteractionTRAF2 interactions

TAX1BP1 TNIP1 ZNF646

2.55e-0460353int:TRAF2
InteractionIKBKE interactions

TAX1BP1 TNIP1

2.71e-0410652int:IKBKE
InteractionOSBPL3 interactions

HIF1AN TNIP1

2.92e-0411052int:OSBPL3
InteractionSLC25A22 interactions

HIF1AN TNIP1

3.59e-0412252int:SLC25A22
InteractionEFEMP1 interactions

TNIP1 ZNF646

3.65e-0412352int:EFEMP1
InteractionCMSS1 interactions

TAX1BP1 TNIP1

3.71e-0412452int:CMSS1
InteractionRIOK2 interactions

TAX1BP1 TNIP1

3.83e-0412652int:RIOK2
InteractionEEF1E1 interactions

TAX1BP1 HIF1AN

4.01e-0412952int:EEF1E1
InteractionGLG1 interactions

TAX1BP1 TNIP1

4.20e-0413252int:GLG1
InteractionRNF115 interactions

TAX1BP1 TNIP1

4.33e-0413452int:RNF115
InteractionAGK interactions

HIF1AN TNIP1

4.33e-0413452int:AGK
InteractionUACA interactions

HIF1AN TNIP1

4.46e-0413652int:UACA
InteractionGTF2B interactions

TNIP1 TBPL1

4.79e-0414152int:GTF2B
InteractionFAM168A interactions

TAX1BP1 TNIP1

4.86e-0414252int:FAM168A
InteractionSDC2 interactions

TAX1BP1 TNIP1

4.93e-0414352int:SDC2
InteractionGABARAP interactions

TAX1BP1 TNIP1

5.07e-0414552int:GABARAP
InteractionCPSF3 interactions

TAX1BP1 TNIP1

5.14e-0414652int:CPSF3
InteractionRAB18 interactions

TAX1BP1 TNIP1

5.21e-0414752int:RAB18
InteractionCCDC86 interactions

TAX1BP1 TNIP1

5.50e-0415152int:CCDC86
InteractionBTF3 interactions

TAX1BP1 HIF1AN TNIP1

5.85e-0479953int:BTF3
InteractionSLTM interactions

TAX1BP1 TNIP1

5.86e-0415652int:SLTM
InteractionTAF4 interactions

TNIP1 TBPL1

5.86e-0415652int:TAF4
InteractionFAM161A interactions

TAX1BP1 TNIP1

5.86e-0415652int:FAM161A
InteractionGABARAPL1 interactions

TAX1BP1 TNIP1

5.94e-0415752int:GABARAPL1
InteractionTCEA2 interactions

TAX1BP1 TNIP1

6.09e-0415952int:TCEA2
InteractionPIP4K2C interactions

HIF1AN TNIP1

6.09e-0415952int:PIP4K2C
InteractionRNF11 interactions

TAX1BP1 TNIP1

6.88e-0416952int:RNF11
InteractionIGHG1 interactions

TAX1BP1 TNIP1

6.88e-0416952int:IGHG1
InteractionFBF1 interactions

HIF1AN TNIP1

7.04e-0417152int:FBF1
InteractionDPM1 interactions

HIF1AN TNIP1

7.20e-0417352int:DPM1
InteractionGLMN interactions

TAX1BP1 TNIP1

7.20e-0417352int:GLMN
InteractionGPC1 interactions

TAX1BP1 TNIP1

7.71e-0417952int:GPC1
InteractionNRSN1 interactions

TAX1BP1 TNIP1

7.71e-0417952int:NRSN1
InteractionGABARAPL2 interactions

TAX1BP1 TNIP1

7.97e-0418252int:GABARAPL2
InteractionAIP interactions

TAX1BP1 HIF1AN

7.97e-0418252int:AIP
InteractionDAZAP2 interactions

TAX1BP1 TNIP1

8.32e-0418652int:DAZAP2
InteractionKIDINS220 interactions

TAX1BP1 HIF1AN

8.41e-0418752int:KIDINS220
InteractionTNFAIP3 interactions

TAX1BP1 TNIP1

8.77e-0419152int:TNFAIP3
InteractionPIBF1 interactions

TAX1BP1 TNIP1

9.61e-0420052int:PIBF1
InteractionPIGT interactions

TAX1BP1 TNIP1

9.70e-0420152int:PIGT
InteractionRPS27L interactions

HIF1AN TNIP1

1.02e-0320652int:RPS27L
InteractionDEK interactions

TAX1BP1 TNIP1

1.05e-0320952int:DEK
InteractionPTDSS1 interactions

HIF1AN TNIP1

1.08e-0321252int:PTDSS1
InteractionATAD3B interactions

HIF1AN TNIP1

1.09e-0321352int:ATAD3B
InteractionTANK interactions

HIF1AN TNIP1

1.12e-0321652int:TANK
InteractionHEATR1 interactions

HIF1AN TNIP1

1.18e-0322252int:HEATR1
InteractionNCOA3 interactions

HIF1AN TNIP1

1.20e-0322452int:NCOA3
InteractionDNAJC11 interactions

TAX1BP1 HIF1AN

1.20e-0322452int:DNAJC11
InteractionNSA2 interactions

TNIP1 ZNF646

1.21e-0322552int:NSA2
InteractionTGM1 interactions

TNIP1 TBPL1

1.25e-0322852int:TGM1
InteractionNFKBIA interactions

HIF1AN TNIP1

1.25e-0322852int:NFKBIA
InteractionCOPG1 interactions

HIF1AN TNIP1

1.26e-0322952int:COPG1
InteractionGPATCH4 interactions

TAX1BP1 TNIP1

1.29e-0323252int:GPATCH4
InteractionIKBKB interactions

TAX1BP1 TNIP1

1.30e-0323352int:IKBKB
InteractionNACA interactions

HIF1AN TNIP1

1.31e-0323452int:NACA
InteractionCDC20 interactions

HIF1AN TNIP1

1.31e-0323452int:CDC20
InteractionBIRC2 interactions

TAX1BP1 TNIP1

1.33e-0323652int:BIRC2
InteractionTXLNA interactions

HIF1AN TNIP1

1.33e-0323652int:TXLNA
InteractionMAP7 interactions

TAX1BP1 TNIP1

1.37e-0323952int:MAP7
InteractionTUBB4A interactions

HIF1AN TNIP1

1.43e-0324452int:TUBB4A
InteractionTAF6 interactions

TNIP1 TBPL1

1.44e-0324552int:TAF6
InteractionSLC25A12 interactions

HIF1AN TNIP1

1.50e-0325052int:SLC25A12
InteractionHDAC1 interactions

TAX1BP1 HIF1AN TNIP1

1.52e-03110853int:HDAC1
InteractionDOCK7 interactions

HIF1AN TNIP1

1.54e-0325452int:DOCK7
InteractionSLC25A11 interactions

HIF1AN TNIP1

1.56e-0325552int:SLC25A11
InteractionABCD3 interactions

HIF1AN TNIP1

1.60e-0325952int:ABCD3
InteractionCHERP interactions

TAX1BP1 TNIP1

1.64e-0326252int:CHERP
InteractionSLC25A13 interactions

HIF1AN TNIP1

1.65e-0326352int:SLC25A13
InteractionGNAS interactions

TAX1BP1 TNIP1

1.67e-0326452int:GNAS
InteractionSLC25A1 interactions

HIF1AN TNIP1

1.74e-0327052int:SLC25A1
CoexpressionGSE22935_UNSTIM_VS_24H_MBOVIS_BCG_STIM_MYD88_KO_MACROPHAGE_UP

TAX1BP1 TNIP1 TBPL1

4.33e-0620053M7781
CoexpressionGSE37533_PPARG1_FOXP3_VS_PPARG2_FOXP3_TRANSDUCED_CD4_TCELL_PIOGLITAZONE_TREATED_UP

TAX1BP1 TNIP1

5.48e-0419652M8970
CoexpressionGSE22313_HEALTHY_VS_SLE_MOUSE_CD4_TCELL_UP

TNIP1 ZNF646

5.54e-0419752M8586
CoexpressionGSE33425_CD161_HIGH_VS_NEG_CD8_TCELL_UP

TAX1BP1 TNIP1

5.65e-0419952M8551
CoexpressionGSE17721_0.5H_VS_8H_GARDIQUIMOD_BMDC_DN

TAX1BP1 TBPL1

5.65e-0419952M4142
CoexpressionGSE9037_WT_VS_IRAK4_KO_BMDM_UP

TAX1BP1 TBPL1

5.71e-0420052M5812
CoexpressionGSE43863_TH1_VS_LY6C_LOW_CXCR5NEG_EFFECTOR_CD4_TCELL_DN

TAX1BP1 TNIP1

5.71e-0420052M9768
CoexpressionGSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_52H_UP

TNIP1 TBPL1

5.71e-0420052M9633
CoexpressionGSE43955_1H_VS_10H_ACT_CD4_TCELL_UP

TNIP1 TBPL1

5.71e-0420052M9658
CoexpressionGSE19198_CTRL_VS_IL21_TREATED_TCELL_24H_UP

TAX1BP1 TNIP1

5.71e-0420052M7233
CoexpressionGSE21546_WT_VS_SAP1A_KO_AND_ELK1_KO_DP_THYMOCYTES_UP

TAX1BP1 ZNF646

5.71e-0420052M7529
CoexpressionGSE20754_WT_VS_TCF1_KO_MEMORY_CD8_TCELL_UP

TAX1BP1 TNIP1

5.71e-0420052M7783
CoexpressionGSE360_L_DONOVANI_VS_L_MAJOR_MAC_DN

TAX1BP1 TNIP1

5.71e-0420052M5232
CoexpressionGSE43956_WT_VS_SGK1_KO_TH17_DIFFERENTIATED_CD4_TCELL_DN

TAX1BP1 TNIP1

5.71e-0420052M9628
CoexpressionJOHNSTONE_PARVB_TARGETS_3_UP

TAX1BP1 TNIP1

2.63e-0343352M2240
CoexpressionTHAKAR_PBMC_INACTIVATED_INFLUENZA_AGE_21_30YO_RESPONDERS_28DY_UP

TAX1BP1 TBPL1

2.76e-0344352M40870
CoexpressionFAN_OVARY_CL11_MURAL_GRANULOSA_CELL

TAX1BP1 TNIP1

2.77e-0344452M41713
CoexpressionSENESE_HDAC3_TARGETS_DN

TAX1BP1 TBPL1

4.18e-0354852M16859
CoexpressionTABULA_MURIS_SENIS_MARROW_MATURE_ALPHA_BETA_T_CELL_AGEING

TAX1BP1 TNIP1

5.19e-0361252MM3804
CoexpressionBENPORATH_SOX2_TARGETS

HIF1AN ZNF646

7.40e-0373452M3835
CoexpressionNAKAYA_PBMC_FLUMIST_AGE_18_50YO_7DY_DN

TNIP1 TBPL1

9.71e-0384452M41129
CoexpressionCHEN_METABOLIC_SYNDROM_NETWORK

TNIP1 TBPL1

2.04e-02124252M1920
CoexpressionCHEN_METABOLIC_SYNDROM_NETWORK

TNIP1 TBPL1

2.28e-02131652MM1052
CoexpressionDIAZ_CHRONIC_MYELOGENOUS_LEUKEMIA_UP

TAX1BP1 TBPL1

2.56e-02139952M535
CoexpressionAtlasFacebaseRNAseq_e8.5_Floor Plate_top-relative-expression-ranked_2500_k-means-cluster#1

TNIP1 TBPL1

4.66e-0346952Facebase_RNAseq_e8.5_Floor Plate_2500_K1
CoexpressionAtlasFacebaseRNAseq_e9.5_Mandibular Arch_top-relative-expression-ranked_2500_k-means-cluster#2

TAX1BP1 TBPL1

6.68e-0356452Facebase_RNAseq_e9.5_Mandibular Arch_2500_K2
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_top-relative-expression-ranked_2500_k-means-cluster#2

TNIP1 TBPL1

7.46e-0359752Facebase_RNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_2500_K2
CoexpressionAtlasFacebaseRNAseq_e10.5_Maxillary Arch_top-relative-expression-ranked_2500_k-means-cluster#5

TAX1BP1 TBPL1

8.26e-0362952Facebase_RNAseq_e10.5_Maxillary Arch_2500_K5
Drug2brn

TNIP1 TBPL1

1.82e-049852CID004369434
DrugLY 294002; Up 200; 10uM; MCF7; HT_HG-U133A_EA

TAX1BP1 TNIP1

6.19e-04181521077_UP
DrugZomepirac sodium salt [64092-48-4]; Down 200; 12.8uM; MCF7; HT_HG-U133A

TAX1BP1 HIF1AN

7.10e-04194523454_DN
DrugAzaguanine-8 [134-58-7]; Down 200; 26.2uM; MCF7; HT_HG-U133A

TAX1BP1 HIF1AN

7.18e-04195527444_DN
Drug16-phenyl tetranor Prostaglandin E2; Down 200; 10uM; PC3; HT_HG-U133A

TAX1BP1 HIF1AN

7.18e-04195527509_DN
Drugprobucol; Up 200; 10uM; MCF7; HG-U133A

HIF1AN ZNF646

7.25e-0419652592_UP
DrugTremorine dihydrochloride [300-68-5]; Down 200; 15uM; MCF7; HT_HG-U133A

TAX1BP1 HIF1AN

7.25e-04196526273_DN
DrugPiromidic acid [19562-30-2]; Down 200; 13.8uM; MCF7; HT_HG-U133A

TAX1BP1 HIF1AN

7.32e-04197523335_DN
DrugThalidomide [50-35-1]; Up 200; 15.4uM; HL60; HG-U133A

HIF1AN TNIP1

7.40e-04198521411_UP
DrugFenspiride hydrochloride [5053-08-7]; Up 200; 13.4uM; MCF7; HT_HG-U133A

HIF1AN ZNF646

7.40e-04198526001_UP
DrugAzlocillin sodium salt [37091-65-9]; Down 200; 8.2uM; MCF7; HT_HG-U133A

TAX1BP1 HIF1AN

7.40e-04198526262_DN
DrugOxytetracycline dihydrate [6153-64-6]; Up 200; 8uM; HL60; HG-U133A

HIF1AN ZNF646

7.40e-04198521553_UP
DrugSTOCK1N-28457; Up 200; 20uM; MCF7; HT_HG-U133A

HIF1AN ZNF646

7.47e-04199526906_UP
Drugnickel chloride

TAX1BP1 HIF1AN TNIP1

1.28e-03117853ctd:C022838
DiseaseMalignant neoplasm of breast

TAX1BP1 TNIP1 ZNF646

4.55e-04107453C0006142
Diseasealkaline phosphatase measurement

HIF1AN TNIP1

1.10e-02101552EFO_0004533
DiseaseC-reactive protein measurement

TNIP1 TBPL1

1.54e-02120652EFO_0004458

Protein segments in the cluster

PeptideGeneStartEntry
FLCHPLPLPSYLHHT

nan

31

Q9N2K0
CLPYPIEHPYHTHIC

C7orf31

141

Q8N865
CLYPYPVHHPCDRQS

HIF1AN

226

Q9NWT6
HLECHYTLTPYIHPH

TAX1BP1

31

Q86VP1
HVEPHPEHLCGAYPY

TNIP1

536

Q15025
PHASYEPELHPAVCY

TBPL1

126

P62380
RLHAQYRPYHCPHCP

ZNF646

286

O15015