Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	monoatomic ion channel activity	LRRC8C CATSPER3 TRPV1 ASIC3 P2RX5 PKDREJ CNGA4	6.91e-05	459	45	7	GO:0005216
GeneOntologyMolecularFunction	monoatomic cation channel activity	CATSPER3 TRPV1 ASIC3 P2RX5 PKDREJ CNGA4	1.14e-04	343	45	6	GO:0005261
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	P2RY8 ADORA2A TRPV1 LPAR2 ADRA2B GPR174 P2RX5 IL6R HLA-DRB1 HLA-DRB3 NLRP6	1.58e-04	1353	45	11	GO:0004888
GeneOntologyMolecularFunction	channel activity	LRRC8C CATSPER3 TRPV1 ASIC3 P2RX5 PKDREJ CNGA4	1.59e-04	525	45	7	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	LRRC8C CATSPER3 TRPV1 ASIC3 P2RX5 PKDREJ CNGA4	1.61e-04	526	45	7	GO:0022803
GeneOntologyMolecularFunction	calcium channel activity	CATSPER3 TRPV1 PKDREJ CNGA4	2.02e-04	129	45	4	GO:0005262
GeneOntologyMolecularFunction	MHC class II receptor activity	HLA-DRB1 HLA-DRB3	2.70e-04	11	45	2	GO:0032395
GeneOntologyMolecularFunction	ligand-gated monoatomic cation channel activity	TRPV1 ASIC3 P2RX5 CNGA4	2.76e-04	140	45	4	GO:0099094
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	CATSPER3 TRPV1 PKDREJ CNGA4	3.68e-04	151	45	4	GO:0015085
GeneOntologyMolecularFunction	bioactive lipid receptor activity	LPAR2 GPR174	5.84e-04	16	45	2	GO:0045125
GeneOntologyMolecularFunction	gated channel activity	CATSPER3 TRPV1 ASIC3 P2RX5 CNGA4	8.97e-04	334	45	5	GO:0022836
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	TRPV1 ASIC3 P2RX5 CNGA4	9.25e-04	193	45	4	GO:0015276
GeneOntologyMolecularFunction	ligand-gated channel activity	TRPV1 ASIC3 P2RX5 CNGA4	9.98e-04	197	45	4	GO:0022834
GeneOntologyMolecularFunction	nucleotide receptor activity	P2RY8 P2RX5	1.11e-03	22	45	2	GO:0016502
GeneOntologyMolecularFunction	purinergic nucleotide receptor activity	P2RY8 P2RX5	1.11e-03	22	45	2	GO:0001614
GeneOntologyMolecularFunction	MHC class II protein complex binding	HLA-DRB1 HLA-DRB3	1.68e-03	27	45	2	GO:0023026
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	LRRC8C CATSPER3 TRPV1 ASIC3 P2RX5 PKDREJ CNGA4	1.84e-03	793	45	7	GO:0015075
GeneOntologyMolecularFunction	intracellularly ligand-gated monoatomic ion channel activity	TRPV1 CNGA4	2.51e-03	33	45	2	GO:0005217
GeneOntologyMolecularFunction	pattern recognition receptor activity	NLRP1 NLRP6	2.82e-03	35	45	2	GO:0038187
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	CATSPER3 TRPV1 ASIC3 P2RX5 PKDREJ CNGA4	3.57e-03	664	45	6	GO:0008324
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	CATSPER3 TRPV1 ASIC3 PKDREJ CNGA4	3.80e-03	465	45	5	GO:0046873
GeneOntologyMolecularFunction	MHC protein complex binding	HLA-DRB1 HLA-DRB3	3.85e-03	41	45	2	GO:0023023
GeneOntologyMolecularFunction	molecular condensate scaffold activity	NLRP1 NLRP6	4.04e-03	42	45	2	GO:0140693
GeneOntologyMolecularFunction	excitatory extracellular ligand-gated monoatomic ion channel activity	TRPV1 P2RX5	4.23e-03	43	45	2	GO:0005231
GeneOntologyMolecularFunction	transmembrane transporter activity	LRRC8C CATSPER3 TRPV1 ASIC3 P2RX5 PKDREJ CNGA4 SLC22A2	4.43e-03	1180	45	8	GO:0022857
GeneOntologyMolecularFunction	voltage-gated calcium channel activity	CATSPER3 TRPV1	4.83e-03	46	45	2	GO:0005245
GeneOntologyMolecularFunction	peptide antigen binding	HLA-DRB1 HLA-DRB3	5.46e-03	49	45	2	GO:0042605
GeneOntologyMolecularFunction	immune receptor activity	IL6R HLA-DRB1 HLA-DRB3	6.10e-03	165	45	3	GO:0140375
GeneOntologyMolecularFunction	lipid binding	TOM1L2 ADORA2A TRPV1 LPAR2 SLC22A2 SNX8 NLRP6	6.22e-03	988	45	7	GO:0008289
GeneOntologyMolecularFunction	transporter activity	LRRC8C CATSPER3 TRPV1 ASIC3 P2RX5 PKDREJ CNGA4 SLC22A2	7.49e-03	1289	45	8	GO:0005215
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	CATSPER3 TRPV1 P2RX5	7.98e-03	182	45	3	GO:0005244
GeneOntologyMolecularFunction	voltage-gated channel activity	CATSPER3 TRPV1 P2RX5	8.22e-03	184	45	3	GO:0022832
GeneOntologyBiologicalProcess	myeloid dendritic cell antigen processing and presentation	HLA-DRB1 HLA-DRB3	1.46e-05	3	46	2	GO:0002469
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of pain	TRPV1 ASIC3	1.46e-05	3	46	2	GO:0050968
GeneOntologyBiologicalProcess	purinergic nucleotide receptor signaling pathway	P2RY8 ADORA2A P2RX5	5.40e-05	33	46	3	GO:0035590
GeneOntologyBiologicalProcess	norepinephrine transport	ADORA2A ADRA2B SLC22A2	8.29e-05	38	46	3	GO:0015874
GeneOntologyBiologicalProcess	positive regulation of T cell mediated immune response to tumor cell	HLA-DRB1 HLA-DRB3	1.01e-04	7	46	2	GO:0002842
GeneOntologyBiologicalProcess	positive regulation of Rho protein signal transduction	P2RY8 LPAR2 GPR174	1.04e-04	41	46	3	GO:0035025
GeneOntologyBiologicalProcess	response to pH	TRPV1 ASIC3 P2RX5	1.78e-04	49	46	3	GO:0009268
GeneOntologyBiologicalProcess	negative regulation of cGAS/STING signaling pathway	ZDHHC18 AURKB	3.17e-04	12	46	2	GO:0160049
GeneOntologyBiologicalProcess	acetylcholine transport	ADORA2A SLC22A2	3.17e-04	12	46	2	GO:0015870
GeneOntologyBiologicalProcess	acetate ester transport	ADORA2A SLC22A2	3.74e-04	13	46	2	GO:1901374
GeneOntologyBiologicalProcess	regulation of T cell mediated immune response to tumor cell	HLA-DRB1 HLA-DRB3	4.35e-04	14	46	2	GO:0002840
GeneOntologyBiologicalProcess	positive regulation of response to biotic stimulus	NLRP1 ZDHHC18 HLA-DRB1 HLA-DRB3 AURKB NLRP6	4.72e-04	451	46	6	GO:0002833
GeneOntologyBiologicalProcess	positive regulation of intracellular signal transduction	P2RY8 TTI1 LPAR2 ADRA2B GPR174 P2RX5 IL6R HLA-DRB1 TMEM33 AURKB	4.80e-04	1299	46	10	GO:1902533
GeneOntologyBiologicalProcess	protein complex oligomerization	LRRC8C NLRP1 TRPV1 HLA-DRB1 NLRP6	4.98e-04	296	46	5	GO:0051259
GeneOntologyBiologicalProcess	regulation of response to biotic stimulus	NLRP1 ZDHHC18 TUT4 HLA-DRB1 HLA-DRB3 AURKB NLRP6	5.15e-04	643	46	7	GO:0002831
GeneOntologyBiologicalProcess	MHC class II protein complex assembly	HLA-DRB1 HLA-DRB3	5.72e-04	16	46	2	GO:0002399
GeneOntologyBiologicalProcess	peptide antigen assembly with MHC class II protein complex	HLA-DRB1 HLA-DRB3	5.72e-04	16	46	2	GO:0002503
GeneOntologyBiologicalProcess	detection of external stimulus	TRPV1 SAG ASIC3 PKDREJ	5.93e-04	173	46	4	GO:0009581
GeneOntologyBiologicalProcess	detection of abiotic stimulus	TRPV1 SAG ASIC3 PKDREJ	6.19e-04	175	46	4	GO:0009582
GeneOntologyBiologicalProcess	epinephrine transport	ADRA2B SLC22A2	6.48e-04	17	46	2	GO:0048241
GeneOntologyBiologicalProcess	T cell mediated immune response to tumor cell	HLA-DRB1 HLA-DRB3	6.48e-04	17	46	2	GO:0002424
GeneOntologyBiologicalProcess	response to abiotic stimulus	LRRC8C KMT2C NLRP1 TRPV1 SAG ASIC3 P2RX5 PKDREJ USP19 AURKB	6.92e-04	1361	46	10	GO:0009628
GeneOntologyCellularComponent	autolysosome membrane	HLA-DRB1 HLA-DRB3	2.83e-05	4	46	2	GO:0120281
GeneOntologyCellularComponent	MHC class II protein complex	HLA-DRB1 HLA-DRB3	6.31e-04	17	46	2	GO:0042613
GeneOntologyCellularComponent	autolysosome	HLA-DRB1 HLA-DRB3	7.09e-04	18	46	2	GO:0044754
GeneOntologyCellularComponent	canonical inflammasome complex	NLRP1 NLRP6	7.09e-04	18	46	2	GO:0061702
GeneOntologyCellularComponent	MHC protein complex	HLA-DRB1 HLA-DRB3	1.49e-03	26	46	2	GO:0042611
GeneOntologyCellularComponent	secondary lysosome	HLA-DRB1 HLA-DRB3	1.49e-03	26	46	2	GO:0005767
Domain	MHC_II_b_N	HLA-DRB1 HLA-DRB3	1.57e-04	8	45	2	PD000328
Domain	MHC_II_beta	HLA-DRB1 HLA-DRB3	2.02e-04	9	45	2	PF00969
Domain	MHC_II_b_N	HLA-DRB1 HLA-DRB3	2.02e-04	9	45	2	IPR000353
Domain	MHC_II_beta	HLA-DRB1 HLA-DRB3	2.02e-04	9	45	2	SM00921
Domain	MHC_II_a/b_N	HLA-DRB1 HLA-DRB3	5.07e-04	14	45	2	IPR014745
Domain	-	HLA-DRB1 HLA-DRB3	5.07e-04	14	45	2	3.10.320.10
Domain	zf-MYND	ANKMY1 USP19	1.16e-03	21	45	2	PF01753
Domain	DAPIN	NLRP1 NLRP6	1.27e-03	22	45	2	PS50824
Domain	DAPIN	NLRP1 NLRP6	1.27e-03	22	45	2	IPR004020
Domain	Znf_MYND	ANKMY1 USP19	1.27e-03	22	45	2	IPR002893
Domain	PYRIN	NLRP1 NLRP6	1.27e-03	22	45	2	SM01289
Domain	ZF_MYND_1	ANKMY1 USP19	1.27e-03	22	45	2	PS01360
Domain	PYRIN	NLRP1 NLRP6	1.27e-03	22	45	2	PF02758
Domain	ZF_MYND_2	ANKMY1 USP19	1.27e-03	22	45	2	PS50865
Domain	NACHT	NLRP1 NLRP6	1.39e-03	23	45	2	PS50837
Domain	NACHT_NTPase	NLRP1 NLRP6	1.39e-03	23	45	2	IPR007111
Domain	DHHC	KMT2C ZDHHC18	1.64e-03	25	45	2	PS50216
Domain	Znf_DHHC_palmitoyltrfase	KMT2C ZDHHC18	1.64e-03	25	45	2	IPR001594
Domain	ENTH_VHS	TOM1L2 TTI1	2.21e-03	29	45	2	IPR008942
Domain	7TM_GPCR_Srsx	ADORA2A LPAR2 ADRA2B	2.48e-03	112	45	3	SM01381
Domain	Ion_trans_dom	CATSPER3 TRPV1 CNGA4	2.61e-03	114	45	3	IPR005821
Domain	Ion_trans	CATSPER3 TRPV1 CNGA4	2.61e-03	114	45	3	PF00520
Domain	MHC_I/II-like_Ag-recog	HLA-DRB1 HLA-DRB3	3.78e-03	38	45	2	IPR011162
Domain	C1-set	HLA-DRB1 HLA-DRB3	7.50e-03	54	45	2	PF07654
Domain	IGc1	HLA-DRB1 HLA-DRB3	8.05e-03	56	45	2	SM00407
Domain	Ig_C1-set	HLA-DRB1 HLA-DRB3	8.61e-03	58	45	2	IPR003597
Domain	Ig/MHC_CS	HLA-DRB1 HLA-DRB3	8.61e-03	58	45	2	IPR003006
Domain	IG_MHC	HLA-DRB1 HLA-DRB3	9.19e-03	60	45	2	PS00290
Pathway	KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	P2RY8 ADORA2A TRPV1 LPAR2 ADRA2B P2RX5	1.96e-05	272	30	6	M13380
Pathway	WP_PURINERGIC_SIGNALING	P2RY8 ADORA2A P2RX5	4.55e-05	33	30	3	M39855
Pathway	BIOCARTA_BBCELL_PATHWAY	HLA-DRB1 HLA-DRB3	2.38e-04	11	30	2	M22030
Pathway	BIOCARTA_EOSINOPHILS_PATHWAY	HLA-DRB1 HLA-DRB3	2.38e-04	11	30	2	M22048
Pathway	BIOCARTA_IL5_PATHWAY	HLA-DRB1 HLA-DRB3	3.37e-04	13	30	2	M18928
Pathway	BIOCARTA_MHC_PATHWAY	HLA-DRB1 HLA-DRB3	3.92e-04	14	30	2	M22023
Pathway	BIOCARTA_BLYMPHOCYTE_PATHWAY	HLA-DRB1 HLA-DRB3	3.92e-04	14	30	2	M1473
Pathway	BIOCARTA_TCRA_PATHWAY	HLA-DRB1 HLA-DRB3	3.92e-04	14	30	2	M10765
Pathway	KEGG_MEDICUS_PATHOGEN_HTLV_1_TAX_TO_NFY_MEDIATED_TRANSCRIPTION	HLA-DRB1 HLA-DRB3	4.52e-04	15	30	2	M47588
Pathway	KEGG_MEDICUS_REFERENCE_ANTIGEN_PROCESSING_AND_PRESENTATION_BY_MHC_CLASS_II_MOLECULES	HLA-DRB1 HLA-DRB3	4.52e-04	15	30	2	M47604
Pathway	BIOCARTA_ASBCELL_PATHWAY	HLA-DRB1 HLA-DRB3	4.52e-04	15	30	2	M7298
Pathway	WP_MAJOR_RECEPTORS_TARGETED_BY_EPINEPHRINE_AND_NOREPINEPHRINE	ADRA2B ADCY9	5.16e-04	16	30	2	M39849
Pathway	KEGG_HEMATOPOIETIC_CELL_LINEAGE	IL6R HLA-DRB1 HLA-DRB3	8.17e-04	87	30	3	M6856
Pathway	BIOCARTA_CSK_PATHWAY	HLA-DRB1 HLA-DRB3	9.85e-04	22	30	2	M6327
Pathway	BIOCARTA_CTLA4_PATHWAY	HLA-DRB1 HLA-DRB3	9.85e-04	22	30	2	M1467
Pathway	BIOCARTA_TH1TH2_PATHWAY	HLA-DRB1 HLA-DRB3	1.08e-03	23	30	2	M6705
Pathway	REACTOME_PD_1_SIGNALING	HLA-DRB1 HLA-DRB3	1.60e-03	28	30	2	M18810
Pathway	BIOCARTA_INFLAM_PATHWAY	HLA-DRB1 HLA-DRB3	1.72e-03	29	30	2	M6910
Pathway	KEGG_ASTHMA	HLA-DRB1 HLA-DRB3	1.84e-03	30	30	2	M13950
Pubmed	HIV-gp 160-induced T cell-dependent B cell differentiation. Role of T cell-B cell activation molecule and IL-6.	IL6R HLA-DRB1 HLA-DRB3	2.58e-07	10	46	3	8450224
Pubmed	HLA-DRB1 and -DRB3 allele frequencies and haplotypic associations in Koreans.	HLA-DRB1 HLA-DRB3	1.71e-06	2	46	2	15041167
Pubmed	Acid-sensing ion channel 3, but not capsaicin receptor TRPV1, plays a protective role in isoproterenol-induced myocardial ischemia in mice.	TRPV1 ASIC3	1.71e-06	2	46	2	21127383
Pubmed	The unusual DRB108:01 haplotype carrying DRB302:02 confirmed in a Dutch family.	HLA-DRB1 HLA-DRB3	1.71e-06	2	46	2	23742216
Pubmed	Paediatric celiac patients carrying the HLA-DR7-DQ2 and HLA-DR3-DQ2 haplotypes display small clinical differences.	HLA-DRB1 HLA-DRB3	1.71e-06	2	46	2	24628273
Pubmed	Enhanced detection of neoantigen-reactive T cells targeting unique and shared oncogenes for personalized cancer immunotherapy.	HLA-DRB1 HLA-DRB3	1.71e-06	2	46	2	30282837
Pubmed	Mutations and selection in the generation of class II histocompatibility antigen polymorphism.	HLA-DRB1 HLA-DRB3	1.71e-06	2	46	2	6589154
Pubmed	Heartburn sensation in nonerosive reflux disease: pattern of superficial sensory nerves expressing TRPV1 and epithelial cells expressing ASIC3 receptors.	TRPV1 ASIC3	1.71e-06	2	46	2	33655767
Pubmed	[An evaluation of HLA class 2 alleles and anti-islet antibodies as evidence for non-autoimmune diabetes in Wolfram syndrome].	HLA-DRB1 HLA-DRB3	1.71e-06	2	46	2	21447263
Pubmed	HLA-DRB1 reduces the risk of type 2 diabetes mellitus by increased insulin secretion.	HLA-DRB1 HLA-DRB3	1.71e-06	2	46	2	21484216
Pubmed	DRB1*03 diversity and DRB3 associations in five major population groups in the United States.	HLA-DRB1 HLA-DRB3	1.71e-06	2	46	2	11872240
Pubmed	A cellular and functional split in the DRw8 haplotype is due to a single amino acid replacement (DR beta ser 57- asp 57).	HLA-DRB1 HLA-DRB3	1.71e-06	2	46	2	2497068
Pubmed	Sensing muscle ischemia: coincident detection of acid and ATP via interplay of two ion channels.	ASIC3 P2RX5	1.71e-06	2	46	2	21092862
Pubmed	The conundrum of HLA-DRB114:01/14:54 and HLA-DRB302:01/02:02 mismatches in unrelated hematopoietic SCT.	HLA-DRB1 HLA-DRB3	1.71e-06	2	46	2	20972469
Pubmed	Distinct roles of ASIC3 and TRPV1 receptors in electroacupuncture-induced segmental and systemic analgesia.	TRPV1 ASIC3	1.71e-06	2	46	2	27896621
Pubmed	Sporadic inclusion body myositis: phenotypic variability and influence of HLA-DR3 in a cohort of 57 Australian cases.	HLA-DRB1 HLA-DRB3	1.71e-06	2	46	2	18258695
Pubmed	Differential effects of ASIC3 and TRPV1 deletion on gastroesophageal sensation in mice.	TRPV1 ASIC3	1.71e-06	2	46	2	17975130
Pubmed	TRPV1 Responses in the Cerebellum Lobules VI, VII, VIII Using Electroacupuncture Treatment for Chronic Pain and Depression Comorbidity in a Murine Model.	TRPV1 ASIC3	1.71e-06	2	46	2	34068557
Pubmed	Development of a new HLA-DRB real-time PCR typing method.	HLA-DRB1 HLA-DRB3	1.71e-06	2	46	2	15620466
Pubmed	Molecular, serological and genetic studies on two new HLA-DRB1 alleles--HLA-DRB10704 and HLA-DRB11507.	HLA-DRB1 HLA-DRB3	1.71e-06	2	46	2	11144299
Pubmed	Regulation of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis: contrasting effects of HLA-DR3 and the shared epitope alleles.	HLA-DRB1 HLA-DRB3	1.71e-06	2	46	2	16320316
Pubmed	Genetic determinants of blood pressure responses to caffeine drinking.	ADORA2A ADRA2B	1.71e-06	2	46	2	22170367
Pubmed	Description of two new HLA-DRB alleles (DRB10310 and DRB301012) found in a Spanish infant.	HLA-DRB1 HLA-DRB3	1.71e-06	2	46	2	9234492
Pubmed	The mechanosensitivity of mouse colon afferent fibers and their sensitization by inflammatory mediators require transient receptor potential vanilloid 1 and acid-sensing ion channel 3.	TRPV1 ASIC3	1.71e-06	2	46	2	16306411
Pubmed	Short-term sensitization of colon mechanoreceptors is associated with long-term hypersensitivity to colon distention in the mouse.	TRPV1 ASIC3	1.71e-06	2	46	2	17553498
Pubmed	Two novel DRB alleles detected by PCR-SSO and confirmed by sequencing: DRB10317 and DRB30210.	HLA-DRB1 HLA-DRB3	1.71e-06	2	46	2	11169247
Pubmed	HLA-DRB103, DRB111 or DRB1*12 and their respective DRB3 specificities in clinical variants of sarcoidosis.	HLA-DRB1 HLA-DRB3	1.71e-06	2	46	2	11169267
Pubmed	Tracking antigen-specific T-cells during clinical tolerance induction in humans.	HLA-DRB1 HLA-DRB3	1.71e-06	2	46	2	20543955
Pubmed	Acid-induced CGRP release from the stomach does not depend on TRPV1 or ASIC3.	TRPV1 ASIC3	1.71e-06	2	46	2	20100279
Pubmed	DRB1*14 diversity and DRB3 associations in four major population groups in the United States.	HLA-DRB1 HLA-DRB3	1.71e-06	2	46	2	12144619
Pubmed	Three new DRB alleles routinely identified by sequence-based typing: DRB1010103, DRB10326 and DRB3*0219.	HLA-DRB1 HLA-DRB3	1.71e-06	2	46	2	15496209
Pubmed	Association of HLA-DR3 with anti-cyclic citrullinated peptide antibody-negative rheumatoid arthritis.	HLA-DRB1 HLA-DRB3	1.71e-06	2	46	2	16200610
Pubmed	HLA-DRB115:01 and HLA-DRB302:02 in PLA2R-Related Membranous Nephropathy.	HLA-DRB1 HLA-DRB3	1.71e-06	2	46	2	28028136
Pubmed	A novel DRB3 allele (DRB30208), a new allelic variant of DRB11502 (DRB115023) and two new DQB1 (DQB103012 and DQB1*0614) alleles.	HLA-DRB1 HLA-DRB3	5.13e-06	3	46	2	9802612
Pubmed	Roles of ASIC3, TRPV1, and NaV1.8 in the transition from acute to chronic pain in a mouse model of fibromyalgia.	TRPV1 ASIC3	5.13e-06	3	46	2	24957987
Pubmed	Polymorphism in the regulatory region of HLA-DRB genes correlating with haplotype evolution.	HLA-DRB1 HLA-DRB3	5.13e-06	3	46	2	8462990
Pubmed	Acid-sensing ion channel 3 is required for agmatine-induced histamine-independent itch in mice.	TRPV1 ASIC3	5.13e-06	3	46	2	36937045
Pubmed	Polymorphism of HLA-DR beta chains in DR4, -7, and -9 haplotypes: implications for the mechanisms of allelic variation.	HLA-DRB1 HLA-DRB3	5.13e-06	3	46	2	3466180
Pubmed	HLA-DR genotypes influence age at disease onset in children and juveniles with type 1 diabetes mellitus.	HLA-DRB1 HLA-DRB3	5.13e-06	3	46	2	20371654
Pubmed	Respiratory virus infection up-regulates TRPV1, TRPA1 and ASICS3 receptors on airway cells.	TRPV1 ASIC3	5.13e-06	3	46	2	28187208
Pubmed	Association of HLA-DR3 and HLA-DR4 with sinonasal polyposis in Mexican Mestizos.	HLA-DRB1 HLA-DRB3	5.13e-06	3	46	2	16815190
Pubmed	Influence of MHC class II genotype on outcome of infection with hepatitis C virus. The HENCORE group. Hepatitis C European Network for Cooperative Research.	HLA-DRB1 HLA-DRB3	5.13e-06	3	46	2	10609818
Pubmed	TDAG8, TRPV1, and ASIC3 involved in establishing hyperalgesic priming in experimental rheumatoid arthritis.	TRPV1 ASIC3	5.13e-06	3	46	2	28827659
Pubmed	Impact of HLA class I high-resolution mismatches on chronic graft-versus-host disease and survival of patients given hematopoietic stem cell grafts from unrelated donors.	HLA-DRB1 HLA-DRB3	5.13e-06	3	46	2	15531903
Pubmed	Crystallographic structure of the human leukocyte antigen DRA, DRB3*0101: models of a directional alloimmune response and autoimmunity.	HLA-DRB1 HLA-DRB3	5.13e-06	3	46	2	17583734
Pubmed	HLA class II influences humoral autoimmunity in patients with type 2 autoimmune hepatitis.	HLA-DRB1 HLA-DRB3	5.13e-06	3	46	2	17050030
Pubmed	Acid-induced pain and its modulation in humans.	TRPV1 ASIC3	5.13e-06	3	46	2	15574747
Pubmed	HLA-DR beta-chain polymorphism. Second domain polymorphism reflects evolutionary relatedness of alleles and may explain public serologic epitopes.	HLA-DRB1 HLA-DRB3	5.13e-06	3	46	2	2471740
Pubmed	Molecular analysis of the HLA class II genes in two DRw6-related haplotypes, DRw13 DQw1 and DRw14 DQw3.	HLA-DRB1 HLA-DRB3	5.13e-06	3	46	2	2493052
Pubmed	Masking of a cathepsin G cleavage site in vivo contributes to the proteolytic resistance of major histocompatibility complex class II molecules.	HLA-DRB1 HLA-DRB3	5.13e-06	3	46	2	20331476
Pubmed	Human leukocyte antigen class II associations with hepatitis C virus clearance and virus-specific CD4 T cell response among Caucasians and African Americans.	HLA-DRB1 HLA-DRB3	5.13e-06	3	46	2	18537178
Pubmed	Immune-induced fever is mediated by IL-6 receptors on brain endothelial cells coupled to STAT3-dependent induction of brain endothelial prostaglandin synthesis.	TRPV1 IL6R	5.13e-06	3	46	2	25429137
Pubmed	Re-evaluation of DRB10702: evidence for only one allele, DRB10701, encoding the beta chain of the HLA-DR7 antigen.	HLA-DRB1 HLA-DRB3	5.13e-06	3	46	2	8016840
Pubmed	Binding domain regulation of MHC class II molecule assembly, trafficking, fate, and function.	HLA-DRB1 HLA-DRB3	5.13e-06	3	46	2	8775462
Pubmed	The association of HLA-DQB1, -DQA1 and -DPB1 alleles with anti- glomerular basement membrane (GBM) disease in Chinese patients.	HLA-DRB1 HLA-DRB3	5.13e-06	3	46	2	21569485
Pubmed	A male-specific increase in the HLA-DRB4 (DR53) frequency in high-risk and relapsed childhood ALL.	HLA-DRB1 HLA-DRB3	5.13e-06	3	46	2	12008082
Pubmed	Frequency and impact of obstetric complications prior and subsequent to unexplained secondary recurrent miscarriage.	HLA-DRB1 HLA-DRB3	5.13e-06	3	46	2	20395221
Pubmed	Long-term follow-up of hepatitis C virus infection: HLA class II loci influences the natural history of the disease.	HLA-DRB1 HLA-DRB3	5.13e-06	3	46	2	12694584
Pubmed	Evidence for association between the HLA-DQA locus and abdominal aortic aneurysms in the Belgian population: a case control study.	HLA-DRB1 HLA-DRB3	1.03e-05	4	46	2	16879749
Pubmed	Allelic variation in the DR subregion of the human major histocompatibility complex.	HLA-DRB1 HLA-DRB3	1.03e-05	4	46	2	3476943
Pubmed	Analyzing the Mycobacterium tuberculosis immune response by T-cell receptor clustering with GLIPH2 and genome-wide antigen screening.	HLA-DRB1 HLA-DRB3	1.03e-05	4	46	2	32341563
Pubmed	Next-Generation Sequencing Reveals That HLA-DRB3, -DRB4, and -DRB5 May Be Associated With Islet Autoantibodies and Risk for Childhood Type 1 Diabetes.	HLA-DRB1 HLA-DRB3	1.03e-05	4	46	2	26740600
Pubmed	Genetic susceptibility to breast cancer: HLA DQB03032 and HLA DRB111 may represent protective alleles.	HLA-DRB1 HLA-DRB3	1.03e-05	4	46	2	11027344
Pubmed	Association of HLA-DR and -DQ genes with narcolepsy in Koreans: comparison with two control groups, randomly selected subjects and DRB11501-DQB10602--positive subjects.	HLA-DRB1 HLA-DRB3	1.03e-05	4	46	2	17002906
Pubmed	Correlation between urothelial differentiation and sensory proteins P2X3, P2X5, TRPV1, and TRPV4 in normal urothelium and papillary carcinoma of human bladder.	TRPV1 P2RX5	1.03e-05	4	46	2	24868547
Pubmed	Contributions of A2A and A2B adenosine receptors in coronary flow responses in relation to the KATP channel using A2B and A2A/2B double-knockout mice.	ADORA2A ADRA2B	1.03e-05	4	46	2	21949117
Pubmed	HLA-DRB alleles and systemic lupus erythematosus in Jamaicans.	HLA-DRB1 HLA-DRB3	1.03e-05	4	46	2	12144077
Pubmed	Blocking A2B adenosine receptor alleviates pathogenesis of experimental autoimmune encephalomyelitis via inhibition of IL-6 production and Th17 differentiation.	ADORA2A ADRA2B	1.03e-05	4	46	2	23225885
Pubmed	Associations of human leukocyte antigen DRB with resistance or susceptibility to HIV-1 infection in the Pumwani Sex Worker Cohort.	HLA-DRB1 HLA-DRB3	1.03e-05	4	46	2	18520346
Pubmed	HLA DR B104, 07-restricted epitopes on Keratin 17 for autoreactive T cells in psoriasis.	HLA-DRB1 HLA-DRB3	1.03e-05	4	46	2	15795121
Pubmed	Analysis of HLA haplotypes in autoimmune hepatitis type 1: identifying the major susceptibility locus.	HLA-DRB1 HLA-DRB3	1.03e-05	4	46	2	11182227
Pubmed	HLA class II alleles in systemic sclerosis patients with anti-RNA polymerase I/III antibody: associations with subunit reactivities.	HLA-DRB1 HLA-DRB3	1.03e-05	4	46	2	14677183
Pubmed	HLA molecules and nasal carriage of Staphylococcus aureus isolated from dialysis and kidney transplant patients at a hospital in Southern Brazil.	HLA-DRB1 HLA-DRB3	1.03e-05	4	46	2	22321387
Pubmed	Molecular analysis of human class II transplantation antigens and their genes.	HLA-DRB1 HLA-DRB3	1.03e-05	4	46	2	6415003
Pubmed	Two major histocompatibility complex haplotypes influence susceptibility to sporadic inclusion body myositis: critical evaluation of an association with HLA-DR3.	HLA-DRB1 HLA-DRB3	1.03e-05	4	46	2	15496200
Pubmed	Human leukocyte antigen association in idiopathic thrombotic thrombocytopenic purpura: evidence for an immunogenetic link.	HLA-DRB1 HLA-DRB3	1.03e-05	4	46	2	19922436
Pubmed	Additional sequence analysis outside exon 2 clarifies DRB112 and DRB114 allelic frequencies in Koreans.	HLA-DRB1 HLA-DRB3	1.03e-05	4	46	2	19286445
Pubmed	The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3.	HLA-DRB1 HLA-DRB3	1.71e-05	5	46	2	7477400
Pubmed	HLA-DRB4 as a genetic risk factor for Churg-Strauss syndrome.	HLA-DRB1 HLA-DRB3	1.71e-05	5	46	2	17763415
Pubmed	HLA class II amino acid epitopes as susceptibility markers of sarcoidosis.	HLA-DRB1 HLA-DRB3	1.71e-05	5	46	2	17559577
Pubmed	NY-ESO-1 119-143 is a promiscuous major histocompatibility complex class II T-helper epitope recognized by Th1- and Th2-type tumor-reactive CD4+ T cells.	HLA-DRB1 HLA-DRB3	1.71e-05	5	46	2	11782380
Pubmed	Antinuclear antibodies and HLA class II alleles in Jamaican patients with systemic lupus erythematosus.	HLA-DRB1 HLA-DRB3	1.71e-05	5	46	2	17910142
Pubmed	Involvement of ASIC3 and Substance P in Therapeutic Ultrasound-Mediated Analgesia in Mouse Models of Fibromyalgia.	TRPV1 ASIC3	1.71e-05	5	46	2	37054767
Pubmed	Major histocompatibility complex class II molecules promote human immunodeficiency virus type 1 assembly and budding to late endosomal/multivesicular body compartments.	HLA-DRB1 HLA-DRB3	1.71e-05	5	46	2	16973583
Pubmed	Genetic variability in HIV-1 gp120 affects interactions with HLA molecules and T cell receptor.	HLA-DRB1 HLA-DRB3	1.71e-05	5	46	2	1970352
Pubmed	Cross-reactive cytotoxic T lymphocytes induced by V3 loop synthetic peptides from different strains of human immunodeficiency virus type 1.	HLA-DRB1 HLA-DRB3	1.71e-05	5	46	2	7645219
Pubmed	A comparison of HLA-DR and -DQ allele and haplotype frequencies in Trinidadian populations of African, South Asian, and mixed ancestry.	HLA-DRB1 HLA-DRB3	1.71e-05	5	46	2	12392858
Pubmed	Association between psoriasis vulgaris and MHC-DRB, -DQB genes as a contribution to disease diagnosis.	HLA-DRB1 HLA-DRB3	1.71e-05	5	46	2	15908298
Pubmed	HLA-DQ8 and the HLA-DQ8-DR4 haplotype are positively associated with the hevein-specific IgE immune response in health care workers with latex allergy.	HLA-DRB1 HLA-DRB3	1.71e-05	5	46	2	12209103
Pubmed	Expansion of monocytic myeloid-derived suppressor cells dampens T cell function in HIV-1-seropositive individuals.	HLA-DRB1 HLA-DRB3	1.71e-05	5	46	2	23152536
Pubmed	HLA-DR-restricted peptides identified in the Nef protein can induce HIV type 1-specific IL-2/IFN-gamma-secreting CD4+ and CD4+ /CD8+ T cells in humans after lipopeptide vaccination.	HLA-DRB1 HLA-DRB3	1.71e-05	5	46	2	17411376
Pubmed	Association of HLA-DR, -DQ, and vitamin D receptor alleles and haplotypes with tuberculosis in the Venda of South Africa.	HLA-DRB1 HLA-DRB3	1.71e-05	5	46	2	16916662
Pubmed	Productive human immunodeficiency virus type 1 assembly takes place at the plasma membrane.	HLA-DRB1 HLA-DRB3	1.71e-05	5	46	2	17507489
Pubmed	Competition of HLA-DR and a beta 2 domain peptide for HIV envelope glycoprotein gp120 binding to CD4.	HLA-DRB1 HLA-DRB3	1.71e-05	5	46	2	7734415
Pubmed	The role of HLA molecules in susceptibility to chronic rheumatic heart disease.	HLA-DRB1 HLA-DRB3	1.71e-05	5	46	2	16426242
Pubmed	Involvement of TRPV1 and TDAG8 in Pruriception Associated with Noxious Acidosis.	TRPV1 ASIC3	1.71e-05	5	46	2	27566399
Pubmed	Visual hallucinations and HLA class II antigens in cortical dementia.	HLA-DRB1 HLA-DRB3	1.71e-05	5	46	2	20606439
Pubmed	HLA-DR and DQB1 gene polymorphism in the North-western Colombian population.	HLA-DRB1 HLA-DRB3	1.71e-05	5	46	2	12144632
Pubmed	HLA-DQA is associated with abdominal aortic aneurysms in the Belgian population.	HLA-DRB1 HLA-DRB3	1.71e-05	5	46	2	17182961
Pubmed	HIV-1 gag polyprotein rescues HLA-DR intracellular transport in a human CD4+ cell line.	HLA-DRB1 HLA-DRB3	1.71e-05	5	46	2	12202216
Interaction	STARD3 interactions	BRINP2 HLA-DRB1 HLA-DRB3 SLC22A2	2.03e-05	74	44	4	int:STARD3
Interaction	TUBA1A interactions	BRINP2 P2RY8 TTI1 NLRP1 UBAC2 HLA-DRB1 HLA-DRB3 TMEM33 AURKB	2.84e-05	749	44	9	int:TUBA1A
Cytoband	Ensembl 112 genes in cytogenetic band chr17p13	NLRP1 TRPV1 P2RX5 AURKB	4.03e-04	346	46	4	chr17p13
Cytoband	17p13.2	NLRP1 TRPV1	1.41e-03	55	46	2	17p13.2
GeneFamily	Zinc fingers MYND-type	ANKMY1 USP19	7.47e-04	21	35	2	87
GeneFamily	Pyrin domain containing\|Pyrin and HIN domain family	NLRP1 NLRP6	1.06e-03	25	35	2	994
GeneFamily	NLR family	NLRP1 NLRP6	1.06e-03	25	35	2	666
GeneFamily	C1-set domain containing	HLA-DRB1 HLA-DRB3	2.99e-03	42	35	2	591
GeneFamily	Histocompatibility complex\|C1-set domain containing	HLA-DRB1 HLA-DRB3	3.27e-03	44	35	2	588
ToppCell	saliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c09-GZMK-FOS_l\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	P2RY8 RPF1 ADRA2B P2RX5	2.20e-05	163	45	4	13f76f2979558f5cd27fbfd1659b413b3cac18f5
ToppCell	wk_08-11-Hematologic_Lymphocytic-B-Immature_B\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	P2RY8 GPR174 P2RX5 HLA-DRB1	3.54e-05	184	45	4	e6669a1b7ea7e4f8e094add5117689470019d85d
ToppCell	human_hepatoblastoma-NK.T_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	P2RY8 NLRP1 GPR174 P2RX5	3.85e-05	188	45	4	71b7599e7e1d63cc0c8518c0501533755951d58f
ToppCell	3'-GW_trimst-1-SmallIntestine-Hematopoietic-Myeloid-cDC1\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	P2RY8 CNGA4 IL6R HLA-DRB1	4.09e-05	191	45	4	9774d423e448ec2d415261e4ad386a81558129b3
ToppCell	Tracheal-10x3prime_v2-Immune_Lymphocytic-T-T_CD4-T_reg\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	P2RY8 ZDHHC18 GPR174 AURKB	4.53e-05	196	45	4	6362fb0b5dc923f19a76b605d7289a16f89220e3
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	P2RY8 NLRP1 GPR174 HLA-DRB1	4.62e-05	197	45	4	0523aec9713ae21e6b879aa98e07fa2576610d5f
ToppCell	Tracheal-10x5prime-Immune_Myeloid-Dendritic_cell-DC_activated\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ADORA2A P2RX5 IL6R HLA-DRB1	4.80e-05	199	45	4	7b3d4c62b11268c7c1599600d8a7b331287cf21a
ToppCell	Control-Control-Myeloid-Neutrophil\|Control / Disease, condition lineage and cell class	NLRP1 ZDHHC18 IL6R NLRP6	4.89e-05	200	45	4	95c41f147a1594d49e73cb56d86d301c3115ce20
ToppCell	Bronchial-10x5prime-Immune_Lymphocytic-T-T_CD4-CD4_naive/CM\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	P2RY8 LPAR2 GPR174 NLRP6	4.89e-05	200	45	4	80f91fbb0779fa9bc2e8230ce70fced90946ea63
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6b-L6b_VISp_Mup5\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TRPV1 CDH18 NLRP6	2.86e-04	127	45	3	6df92f80b8922ca00eb383f79cd8dda4d602adfc
ToppCell	Smart-seq2-bone_marrow_(Smart-seq2)-lymphocytic-B_lymphocytic-memory_B_cell\|bone_marrow_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SAG P2RX5 HLA-DRB1	3.06e-04	130	45	3	3f1d1ce7af17c3642f75bb60f2bbf4562354f105
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6b-L6b_VISp_Col8a1_Rxfp1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ADORA2A CDH18 NLRP6	3.13e-04	131	45	3	81efe8b0ca4377e557a42ddb12aecaf3f46b15bf
ToppCell	Smart-seq2-spleen_(Smart-seq2)-lymphocytic-B_lymphocytic-naive_B_cell\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	TUT4 P2RX5 HLA-DRB1	3.13e-04	131	45	3	d76a7a9b50ee6d24b74494c6f6b88b3506b3f9ad
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6b-L6b_VISp_Col8a1_Rprm\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ADORA2A CDH18 NLRP6	3.20e-04	132	45	3	66ec5a06eece27c0aafb548f51db9fee595e71bc
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6b\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TRPV1 CDH18 NLRP6	3.88e-04	141	45	3	5ef3166c5271aa90fd0633016edfe2c74b835319
ToppCell	Control-Myeloid-Dendritic_cells\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	P2RY8 NLRP1 LPAR2	4.05e-04	143	45	3	bb8d4c335682d1a6798bed0de8bb0603054a4944
ToppCell	Control-Myeloid-Dendritic_cells-pDC\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	P2RY8 NLRP1 LPAR2	4.21e-04	145	45	3	bab85a72142b6257f7d424e5301f65b6dcdf745d
ToppCell	facs-Lung-3m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LDLRAD2 CNGA4 CDH18	4.47e-04	148	45	3	5983c4546f527a0b599cfcbd8a6cb937a1d6f895
ToppCell	Dividing_Macrophages-Donor_01\|World / lung cells shred on cell class, cell subclass, sample id	ASIC3 FAM110B AURKB	4.83e-04	152	45	3	e39cfc346b35235546b303e7d73e4d9d7120a5fb
ToppCell	PBMC-Control-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TUT4 P2RX5 HLA-DRB1	5.61e-04	160	45	3	7ad065337ac802de52c15ee715f6b78a3eed0cef
ToppCell	5'-Adult-LymphNode-Hematopoietic-B_cells-Cycling_B_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	P2RY8 P2RX5 HLA-DRB1	5.72e-04	161	45	3	d8140e7772b4e327dafa3536881a784d3c328d2a
ToppCell	Bac-SEP-Lymphocyte-B-B_intermediate\|Bac-SEP / Disease, Lineage and Cell Type	ASIC3 P2RX5 HLA-DRB1	5.72e-04	161	45	3	bcd122af09cbb99d1816200d9c367af8b7f36873
ToppCell	Influenza_Severe-Neutrophil\|Influenza_Severe / Disease group and Cell class	ZDHHC18 LPAR2 ADRA2B	5.72e-04	161	45	3	98c95b1b85d5427415af2ca8fb14849e97f6e8b5
ToppCell	10x5'-bone_marrow-Lymphocytic_B-ABC_aged-B_naive\|bone_marrow / Manually curated celltypes from each tissue	P2RX5 LYRM4 HLA-DRB1	5.82e-04	162	45	3	44832055b11a789e320c802aadb345e065defc8f
ToppCell	facs-Pancreas-Exocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CSRNP2 PKDREJ CTDSPL2	5.92e-04	163	45	3	953a7db7e90a913e81002d2141fbbd5f1fdf2197
ToppCell	3'-GW_trimst-1-LargeIntestine-Hematopoietic-B_cells-CLP\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	P2RY8 GPR174 P2RX5	6.03e-04	164	45	3	f5cacd7b2329cb0c7c1696eb4d8f89a4bbd9dda1
ToppCell	facs-Trachea-3m-Hematologic-myeloid-granulocyte-granulocyte_l26\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADORA2A SAG GPR174	6.14e-04	165	45	3	23955e3373660f827518e723ac62fba99753f375
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_naive-B_naive-1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TUT4 P2RX5 HLA-DRB1	6.14e-04	165	45	3	fead3f2032f8fa5f7f0159a4434989b3d65debbb
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	P2RY8 LRRC8C NLRP1	6.14e-04	165	45	3	6a621b300442c52adfc15b61d3a6d3a3cb00099f
ToppCell	facs-Lung-ENDOMUCIN-18m-Myeloid-Classical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NLRP1 IL6R AURKB	6.25e-04	166	45	3	82fa07632f7e586698fbf37381715b40f9f6ae3a
ToppCell	facs-Lung-ENDOMUCIN-18m-Myeloid-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NLRP1 IL6R AURKB	6.25e-04	166	45	3	0d03926452414f232c77fd15d5f48d148f9fca3b
ToppCell	LPS-IL1RA+antiTNF-Lymphocytic_B-B_cells-B-cells\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	P2RY8 NLRP1 SAG	6.47e-04	168	45	3	eeb381b62c7ba263af96de1194ed59e57b6ca3ae
ToppCell	LPS-IL1RA+antiTNF-Lymphocytic_B-B_cells\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	P2RY8 NLRP1 SAG	6.47e-04	168	45	3	063d0368d656962b335154c230bdcd9236e7c9ad
ToppCell	5'-GW_trimst-2-LymphNode-Hematopoietic-Myeloid-Lymphoid_DC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	P2RY8 ADORA2A IL6R	6.47e-04	168	45	3	6dd58fd981750da49afd53796f244e1803cce97f
ToppCell	LPS-IL1RA+antiTNF-Lymphocytic_B\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	P2RY8 NLRP1 SAG	6.47e-04	168	45	3	a7c4251d8a83bc30196a444028a35c17c24dc291
ToppCell	PCW_05-06-Hematologic_Myeloid-Hem_Myeloid_dendritic-im_conventional_dendritic_(19)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	P2RY8 GPR174 HLA-DRB1	6.47e-04	168	45	3	907692c1f03d3c9889ba1bed5a4844e2c379db8e
ToppCell	3'-Adult-SmallIntestine-Hematopoietic-B_cells-Cycling_B_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	P2RY8 P2RX5 NLRP6	6.58e-04	169	45	3	203971cceeba150d0e8891c92662545e84c77837
ToppCell	droplet-Kidney-nan-3m-Lymphocytic-CD45____B_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR174 IL6R SNX8	6.69e-04	170	45	3	6210ee3bf29059e6149c047bb7e02c5f59441519
ToppCell	control\|World / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	NLRP1 LPAR2 HLA-DRB1	6.81e-04	171	45	3	837c1186504f110ccf5b580d9cd4e50ca60c173f
ToppCell	droplet-Thymus-nan-21m-Lymphocytic-Macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NLRP1 ATXN7L1 ADCY9	6.81e-04	171	45	3	a474aaed3ca4cacb0ab565c35f25d92a10f531b7
ToppCell	10x5'v1-week_17-19-Lymphocytic_B-B_lineage-immature_B_cell\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	TRPV1 SAG P2RX5	6.81e-04	171	45	3	5636ec11ed1f7aacf98cd9e85853ee1a05bd2cf2
ToppCell	wk_08-11-Hematologic_Lymphocytic-B\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	P2RY8 P2RX5 HLA-DRB1	6.92e-04	172	45	3	d1ab8f493b70ec995281f9fb0991f1d3aa7b928f
ToppCell	facs-Lung-18m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADORA2A TMEM30CP P2RX5	6.92e-04	172	45	3	48d0cfc37d1b1ae48ed8f8b2711abeb609d2bb6e
ToppCell	15-Airway-Immune-Hematopoietic,_B_Cells\|Airway / Age, Tissue, Lineage and Cell class	P2RY8 P2RX5 HLA-DRB1	6.92e-04	172	45	3	36f2444754f1e37683cb812380e6b05b356f9f4a
ToppCell	3'-GW_trimst-2-LargeIntestine-Hematopoietic-B_cells-Pre-B\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SAG P2RX5 HLA-DRB1	7.04e-04	173	45	3	67c342295b8a06ce38e081ba74478c568917a396
ToppCell	IIH-CD8-naive_CD4\|IIH / Condition, Cell_class and T cell subcluster	RPF1 ANKMY1 USP19	7.04e-04	173	45	3	4f2843371d18af766c1892529ce286f56c956fde
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-B_cells-Cycling_B_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	P2RX5 HLA-DRB1 AURKB	7.04e-04	173	45	3	b7e0193fd4983cb38d1bee441f608f73ee8743b9
ToppCell	PND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TUT4 GPR174 SNX8	7.16e-04	174	45	3	26ca6ebaa0081108d44c01f8ca56a63724f1c99d
ToppCell	356C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	LPAR2 ASIC3 HLA-DRB1	7.16e-04	174	45	3	99d7421ad5eafe7751ef90698a92f683aa33bca8
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	LDLRAD2 P2RX5 HLA-DRB1	7.16e-04	174	45	3	ebe6ce173ad12d4a2afa39f8d6185c0e4f97fb1e
ToppCell	PND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TUT4 GPR174 SNX8	7.16e-04	174	45	3	7c8704766dd4c80250754b5ee9907b342b9c2623
ToppCell	PND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TUT4 GPR174 SNX8	7.16e-04	174	45	3	9aa2168d3bcef7cdc5a47442618cb8e9eb24c95b
ToppCell	11.5-Distal-Immune-Hematopoietic,_B_Cells\|Distal / Age, Tissue, Lineage and Cell class	P2RY8 P2RX5 HLA-DRB1	7.28e-04	175	45	3	d8ca8fbe5309dab293c335b32f1b138edfdd0b07
ToppCell	wk_20-22-Hematologic-Myeloid-Promonocyte-like\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	TRPV1 IL6R AURKB	7.28e-04	175	45	3	654299df246debe0a5b12f0d9568eb828bb94bb9
ToppCell	10x5'v1-week_14-16-Myeloid_DC-DC-DC1\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	ADRA2B CNGA4 HLA-DRB1	7.28e-04	175	45	3	398e2504021f587166ad04a2f0662bfcb4e1c0df
ToppCell	wk_08-11-Hematologic_Lymphocytic-B-Large_pre-B\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	P2RY8 P2RX5 HLA-DRB1	7.40e-04	176	45	3	78417a5ac2e45e97e7b4c56c78c25879a1b58f97
ToppCell	Adult-Immune-dendritic_cell-D175\|Adult / Lineage, Cell type, age group and donor	P2RY8 ZDHHC18 LDLRAD2	7.40e-04	176	45	3	1f0f1f953e6d61119f342de0d980aa1287511dba
ToppCell	COVID-19_Moderate-B_intermediate\|COVID-19_Moderate / disease group, cell group and cell class	P2RX5 HLA-DRB1 NLRP6	7.52e-04	177	45	3	68e3d12a0c048a2d0f1b9680c7338a35855bba30
ToppCell	3'-Adult-SmallIntestine-Hematopoietic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	P2RY8 NLRP1 P2RX5	7.65e-04	178	45	3	da1695a936dbe3ca9ee3fb28ceb60511c47b35f8
ToppCell	3'-Adult-SmallIntestine-Hematopoietic-B_cells\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	P2RY8 NLRP1 P2RX5	7.65e-04	178	45	3	580fc1d45b82010c665a313b2e7a21e0116819ef
ToppCell	Control-Myeloid-Monocytes,_Macrophages-Monocytes-Macrophages\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	P2RY8 NLRP1 IL6R	7.77e-04	179	45	3	c4ff8b191ed0f6dc2dd784869f6f2c62e170a7db
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Hematopoietic-Myeloid-cDC2\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	P2RY8 IL6R HLA-DRB1	7.77e-04	179	45	3	ce95b601bf17ae8167d382a105384b9e65e9407f
ToppCell	Control-Myeloid-Monocytes,_Macrophages\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	P2RY8 NLRP1 IL6R	7.77e-04	179	45	3	a79a244bf8ecc333d034b2eb2de554d3310ca6de
ToppCell	facs-Heart-RV-24m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BRINP2 ADRA2B ADCY9	7.90e-04	180	45	3	a37cc885fe3f6cb9df69d43358064c83c18412e7
ToppCell	Adult-Immune-T_lymphocyte-D122\|Adult / Lineage, Cell type, age group and donor	P2RY8 NLRP1 GPR174	7.90e-04	180	45	3	06c371d0f0c5a7b234dd143e98800e19af95a8b5
ToppCell	facs-Heart-RV-24m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BRINP2 ADRA2B ADCY9	7.90e-04	180	45	3	63a6d532b16b8b15c7c9102148d7297ee3afd641
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Hematopoietic-Myeloid\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	P2RY8 IL6R HLA-DRB1	8.02e-04	181	45	3	090e89b506d945e123e647d08947e9649a65ce7c
ToppCell	droplet-Lung-LUNG-30m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TUT4 GPR174 SNX8	8.02e-04	181	45	3	46de8c18e4ec8dc9d07f7c8cc7b5f48b9c613aae
ToppCell	3'-GW_trimst-1-SmallIntestine-Hematopoietic-B_cells-CLP\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	P2RY8 GPR174 P2RX5	8.02e-04	181	45	3	1110a0375189c034e6b02e6ebceb7084e4590114
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic-B_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TUT4 GPR174 SNX8	8.02e-04	181	45	3	477c572c5c1efceee49732cc9e8b1dad68a7e6e5
ToppCell	11.5-Airway-Immune-Hematopoietic,_B_Cells\|Airway / Age, Tissue, Lineage and Cell class	P2RY8 P2RX5 HLA-DRB1	8.02e-04	181	45	3	727344d7b2953568b7b3463398c7d56878cf2c2b
ToppCell	Control-Myeloid\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	P2RY8 NLRP1 IL6R	8.02e-04	181	45	3	25170e5285996cc80337d5f86a0255569861ae77
ToppCell	Healthy-multiplets\|World / disease group, cell group and cell class	LDLRAD2 LYRM4 SNX8	8.02e-04	181	45	3	f8dbac3cd500cc8d80853312b00d124c27b8fd85
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic-B_cell-B_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TUT4 GPR174 SNX8	8.02e-04	181	45	3	909280b44085d8e96fcd3cbcba6bff94badd41e8
ToppCell	droplet-Lung-LUNG-30m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TUT4 GPR174 SNX8	8.02e-04	181	45	3	ce0e39114bf3bcbcce0fd4c0d70bedadd0853e1d
ToppCell	droplet-Marrow-nan-3m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TUT4 GPR174 CTDSPL2	8.15e-04	182	45	3	1710eab3037a87609d21838be2d2d29c3bc36651
ToppCell	droplet-Marrow-nan-3m-Hematologic-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TUT4 GPR174 CTDSPL2	8.15e-04	182	45	3	e78ba2c5cae480c16a596ce7c3bf2d480becacf4
ToppCell	facs-Heart-LA-3m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BRINP2 ADRA2B PKDREJ	8.28e-04	183	45	3	8d45dff06a199b1369576657f7f9dc0249c5f841
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Lymphocytic-B_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZDHHC18 GPR174 SNX8	8.28e-04	183	45	3	20f7b6ec2462032eda957a893ca76d5a5a01333d
ToppCell	PCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_dendritic-im_conventional_dendritic_(19)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	P2RY8 PKDREJ HLA-DRB1	8.28e-04	183	45	3	24679153b654c148dbd572e9013c0a6e58718ada
ToppCell	facs-Heart-LA-3m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BRINP2 ADRA2B PKDREJ	8.28e-04	183	45	3	421265fa15d5a028cb567bb0904e670473ef102b
ToppCell	10x5'-blood-Myeloid_Dendritic-DC1\|blood / Manually curated celltypes from each tissue	LDLRAD2 LYRM4 HLA-DRB1	8.42e-04	184	45	3	09fa465d1852b9b7e0405c27d4e5de276c9ba871
ToppCell	cellseq2-Immune-Lymphocytic_B-Lymphocytic_B-B\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	P2RY8 P2RX5 HLA-DRB1	8.42e-04	184	45	3	efcd643324ccd212350dc6a27f40efbb666d557b
ToppCell	15-Distal-Immune-Hematopoietic,_B_Cells\|Distal / Age, Tissue, Lineage and Cell class	P2RY8 P2RX5 HLA-DRB1	8.42e-04	184	45	3	c294cd421f277992b56ae9c40b8f3948e33148fe
ToppCell	droplet-Lung-nan-18m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TUT4 GPR174 SNX8	8.55e-04	185	45	3	d4076294571557c223f5b68244e9c53e1d8f0343
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TUT4 P2RX5 HLA-DRB1	8.68e-04	186	45	3	1a1e5d85a5ad90afee234c12a9b54a5e93a8a2f2
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B-B_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TUT4 P2RX5 HLA-DRB1	8.68e-04	186	45	3	f1366638edaecad5cad6367440f4c693513bed7e
ToppCell	CD8+_Memory_T_cell-FLU-0\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	SAG HLA-DRB1 NLRP6	8.68e-04	186	45	3	b5edd4ec462c7cd87f567b8b6f86259ddbbf096d
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	P2RY8 NLRP1 GPR174	8.68e-04	186	45	3	9d576dce2c5deefef1adda16c6da7055c8d57f8f
ToppCell	wk_08-11-Hematologic-Myeloid-Cycling_DC\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	P2RY8 IL6R HLA-DRB1	8.68e-04	186	45	3	de1f0bc5dbf6dc0e716f5ebbf2bbcfe249811c54
ToppCell	Influenza-Influenza_Severe-Myeloid-Neutrophil\|Influenza_Severe / Disease, condition lineage and cell class	ZDHHC18 LPAR2 ADRA2B	8.68e-04	186	45	3	1dfcec9196d4db76fba3abc74e85885b1fb98b87
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-10\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	P2RX5 HLA-DRB1 SNX8	8.68e-04	186	45	3	d7d884ff4184636081c350d29f797bd923c6a3b4
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK-T_Cell-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	P2RY8 NLRP1 GPR174	8.68e-04	186	45	3	bd3bd022b575d9b0ef90d50a5cb874085a827b77
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK-T_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	P2RY8 NLRP1 GPR174	8.68e-04	186	45	3	924cc357b4c4ce8e9b05773bdab544f0b65474cc
ToppCell	(1)_B_CD27neg\|World / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)	P2RY8 P2RX5 HLA-DRB1	8.68e-04	186	45	3	646389147189760e9493c4f50f9583959ef0ee26
ToppCell	droplet-Liver-LIVER_HEP-30m-Lymphocytic-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KMT2C IL6R FAM110B	8.68e-04	186	45	3	f5468e03321ea2083e223eb0d92c3a9307039569
ToppCell	Control-T_cells\|Control / group, cell type (main and fine annotations)	P2RY8 LRRC8C GPR174	8.82e-04	187	45	3	f4e8e0eba58da89b56587667555a5d4754e108c7
ToppCell	normal-na-Lymphocytic_B-B_atypical-female\|normal / PBMC cell types (v2) per disease, treatment status, and sex	P2RX5 HLA-DRB1 SNX8	8.95e-04	188	45	3	e5ab89030783461e9367ab87c353fb5c31911020
ToppCell	3'-GW_trimst-2-SmallIntestine-Hematopoietic-B_cells\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	P2RY8 P2RX5 HLA-DRB1	8.95e-04	188	45	3	7447051dcdb949adc6af5814188674a489adf71f
ToppCell	normal-na-Lymphocytic_B-B_atypical\|normal / PBMC cell types (v2) per disease, treatment status, and sex	P2RX5 HLA-DRB1 SNX8	8.95e-04	188	45	3	13653481d64c7a1ad833d738a3ee0bb9def7cec7
Drug	AC1L1F6H	ADORA2A LPAR2 ADRA2B P2RX5 ADCY9	2.10e-06	106	45	5	CID000003104
Drug	Nocodazole	IL6R SLC22A2 ANAPC2 AURKB	7.28e-06	63	45	4	ctd:D015739
Drug	Lopac-P-178	ADORA2A NLRP1 TRPV1 P2RX5	9.32e-06	67	45	4	CID005478935
Drug	2-(aminomethyl)pyrrolidine	P2RY8 ADORA2A TRPV1 P2RX5 ADCY9	1.62e-05	161	45	5	CID000072032
Drug	desipramine	ADORA2A NLRP1 ADRA2B TRNT1 ADCY9	3.40e-05	188	45	5	CID000002995
Drug	Gi-2	ADORA2A LPAR2 ADRA2B TRNT1 ADCY9	4.05e-05	195	45	5	CID011957432
Drug	Dihydroergotoxine mesylate [8067-24-1]; Up 200; 6.4uM; MCF7; HT_HG-U133A	ADORA2A ASIC3 ATXN7L1 IL6R USP19	4.15e-05	196	45	5	2793_UP
Disease	extranodal nasal NK/T cell lymphoma	HLA-DRB1 HLA-DRB3	3.40e-05	6	45	2	MONDO_0019472
Disease	aspirin-induced respiratory disease (is_implicated_in)	HLA-DRB1 HLA-DRB3	1.24e-04	11	45	2	DOID:0080822 (is_implicated_in)
Disease	eosinophil percentage of leukocytes	P2RY8 UBAC2 TRNT1 ATXN7L1 HLA-DRB1 HLA-DRB3 ANAPC2	1.26e-04	746	45	7	EFO_0007991
Disease	hepatitis B virus infection	HLA-DRB1 HLA-DRB3	3.83e-04	19	45	2	EFO_0004197
Disease	vitiligo (is_implicated_in)	NLRP1 HLA-DRB1	4.69e-04	21	45	2	DOID:12306 (is_implicated_in)
Disease	glycoprotein measurement	CTDSPL2 HLA-DRB1 SLC22A2	8.02e-04	119	45	3	EFO_0004555
Disease	alkaline phosphatase measurement	ZDHHC18 SAG TEAD1 LDLRAD2 IL6R HLA-DRB1 SLC22A2	8.08e-04	1015	45	7	EFO_0004533
Disease	monocyte percentage of leukocytes	ZDHHC18 ADRA2B IL6R HLA-DRB1 ADCY9 NLRP6	8.10e-04	731	45	6	EFO_0007989
Disease	nephrolithiasis	SAG SLC22A2	1.17e-03	33	45	2	EFO_0004253
Disease	chylomicron measurement, triglycerides:total lipids ratio, very low density lipoprotein cholesterol measurement	HLA-DRB1 SLC22A2	1.24e-03	34	45	2	EFO_0008317, EFO_0008596, EFO_0020947
Disease	Drug Allergy	ADORA2A HLA-DRB1	1.31e-03	35	45	2	C0013182
Disease	duodenal ulcer	CNGA4 SLC22A2	1.39e-03	36	45	2	EFO_0004607
Disease	Graves' disease (is_implicated_in)	HLA-DRB1 HLA-DRB3	1.63e-03	39	45	2	DOID:12361 (is_implicated_in)
Disease	asthma (is_implicated_in)	ADORA2A HLA-DRB1 HLA-DRB3	1.78e-03	157	45	3	DOID:2841 (is_implicated_in)
Disease	Anorectal Malformations	CDH18 FAM110B	1.80e-03	41	45	2	C3495676
Disease	chylomicron measurement, very low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio	HLA-DRB1 SLC22A2	1.88e-03	42	45	2	EFO_0008317, EFO_0008596, EFO_0020945
Disease	triglycerides in large LDL measurement	HLA-DRB1 SLC22A2	1.97e-03	43	45	2	EFO_0022319
Disease	total lipids in small LDL	HLA-DRB1 SLC22A2	2.35e-03	47	45	2	EFO_0022168
Disease	free cholesterol in medium VLDL measurement	HLA-DRB1 SLC22A2	2.35e-03	47	45	2	EFO_0022269

Protein segments in the cluster

Peptide	Gene	Start	Entry
FFYRIYASLRIEELF	ANAPC2	331	Q9UJX6
IYQVYVRLRPFFREF	CTDSPL2	321	Q05D32
RYRLFRLLEFSEIFF	CATSPER3	76	Q86XQ3
FIYAYRIREFRQTFR	ADORA2A	286	P29274
VRFDQVTVYYFARRQ	CSRNP2	66	Q9H175
YTIFNQDFRRAFRRI	ADRA2B	426	P18089
LTFRRDLYFSRVQVY	SAG	81	P10523
RGYYVFDRRWDRFRF	ATXN7L1	476	Q9ULK2
FVYYFASREFQLRLR	P2RY8	291	Q86VZ1
RIRFQFRFFLVYSLT	LDLRAD2	76	Q5SZI1
LSYFAVFRRVYVQRD	KMT2C	4516	Q8NEZ4
MVAVYTRIFFYVRRR	LPAR2	201	Q9HBW0
YRYFTDERQAIRAFR	NLRP1	491	Q9C000
FLYQVAERVRYYREF	ASIC3	56	Q9UHC3
IYYFSTNEFRRRLSR	GPR174	291	Q9BXC1
FFNGTERVRYLDRYF	HLA-DRB3	46	P79483
SSFYRLRFELRYRAE	IL6R	246	P08887
FFNGTERVRFLDRYF	HLA-DRB1	46	P01911
QTQRRFRYALFYIGF	ADCY9	111	O60503
AVDYGYFRFFQDRRI	ANKMY1	781	Q9P2S6
YNYRTYAVRRIRDAF	LYRM4	26	Q9HD34
TRRRRFSRTVQDVYY	CDH18	551	Q13634
RYFRVDADVERFFNY	FAM110B	266	Q8TC76
HRLYFTARRVLFVFF	TMEM30CP	26	A0ZSE6
RRYRRTVGIFYQVAY	SLC22A2	231	O15244
YFRDERRAERAYRFV	NLRP6	361	P59044
RFARYYRDAAGVEFR	P2RX5	296	Q93086
IQEDYLRILRYFRFY	TRNT1	191	Q96Q11
RFKSSVYRRYNDFVV	SNX8	101	Q9Y5X2
LRYSRFFYDVRLAQR	PKDREJ	2066	Q9NTG1
AIYRFITERFAFYRD	FOXE3	96	Q13461
ERYRQGFTTRYRIYR	BRINP2	76	Q9C0B6
FERLRRQYLYSFYFS	CNGA4	211	Q8IV77
NILRLYNYFYDRRRI	AURKB	136	Q96GD4
DYIFFRFHRYIFRSE	RPF1	286	Q9H9Y2
VVTRYAYVLFYRRRN	USP19	1201	O94966
VYFFFRGIQYFLQRR	TRPV1	486	Q8NER1
YTRELSRQRFRQFCY	ZBED9	46	Q6R2W3
LIYNFRIFERRYGSR	UBAC2	76	Q8NBM4
YARFENGRFVYRINR	TEAD1	341	P28347
NNVFLRYERFERYRS	TOM1L2	296	Q6ZVM7
LVYEYVVERFRAAYR	TUT4	691	Q5TAX3
LYQIFREMYVRFFFR	TBC1D19	386	Q8N5T2
FIYYRFLTLRYSSRR	TMEM33	186	P57088
RRNYRFFYAFILSLS	ZDHHC18	231	Q9NUE0
IQRRYFRFFTDERIF	TTI1	471	O43156
LFYRSLREYSFEYVR	LRRC8C	341	Q8TDW0