Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone H3K4me/H3K4me2/H3K4me3 demethylase activity	KDM5C KDM5D	1.28e-04	6	59	2	GO:0034647
GeneOntologyMolecularFunction	histone binding	JAK2 TSPY3 TSPY10 TSPY2 TSPY8 TSPY1	1.29e-04	265	59	6	GO:0042393
GeneOntologyMolecularFunction	histone H3K4 demethylase activity	KDM5C KDM5D	2.38e-04	8	59	2	GO:0032453
GeneOntologyBiologicalProcess	gonadal mesoderm development	TSPY3 TSPY10 TSPY2 TSPY8 TSPY1	2.01e-11	9	59	5	GO:0007506
GeneOntologyBiologicalProcess	mesoderm development	JAK2 TSPY3 TSPY10 TSPY2 TSPY8 TSPY1	5.71e-06	157	59	6	GO:0007498
GeneOntologyBiologicalProcess	chromatin remodeling	JAK2 KDM5C SETBP1 TSPY3 TSPY10 TSPY2 TSPY8 TSPY1 KDM5D ZBTB1 EP300	6.93e-06	741	59	11	GO:0006338
GeneOntologyBiologicalProcess	nucleosome assembly	TSPY3 TSPY10 TSPY2 TSPY8 TSPY1	2.59e-05	122	59	5	GO:0006334
GeneOntologyBiologicalProcess	chromatin organization	JAK2 KDM5C SETBP1 TSPY3 TSPY10 TSPY2 TSPY8 TSPY1 KDM5D ZBTB1 EP300	4.04e-05	896	59	11	GO:0006325
GeneOntologyBiologicalProcess	nucleosome organization	TSPY3 TSPY10 TSPY2 TSPY8 TSPY1	5.35e-05	142	59	5	GO:0034728
GeneOntologyBiologicalProcess	protein-DNA complex assembly	TSPY3 TSPY10 TSPY2 TSPY8 TSPY1 EP300	7.69e-05	249	59	6	GO:0065004
GeneOntologyBiologicalProcess	somite specification	MEOX1 MEOX2	8.00e-05	5	59	2	GO:0001757
GeneOntologyBiologicalProcess	protein-DNA complex organization	JAK2 KDM5C SETBP1 TSPY3 TSPY10 TSPY2 TSPY8 TSPY1 KDM5D ZBTB1 EP300	1.07e-04	999	59	11	GO:0071824
GeneOntologyCellularComponent	chromatin	JAK2 KDM5C TSPY3 TSPY10 TSPY2 ZFPM1 TSPY8 TSPY1 KDM5D EP300 PRM2 MEOX1 MEOX2	2.00e-04	1480	59	13	GO:0000785
Domain	NAP	TSPY10 TSPY2 TSPY8	1.87e-05	17	58	3	PF00956
Domain	NAP_family	TSPY10 TSPY2 TSPY8	1.87e-05	17	58	3	IPR002164
Domain	Lys_sp_deMease-like_dom	KDM5C KDM5D	5.66e-05	4	58	2	IPR013637
Domain	PLU-1	KDM5C KDM5D	5.66e-05	4	58	2	PF08429
Domain	zf-C5HC2	KDM5C KDM5D	9.42e-05	5	58	2	PF02928
Domain	Znf_C5HC2	KDM5C KDM5D	9.42e-05	5	58	2	IPR004198
Domain	Mob1_phocein	MOB3C MOB4	1.97e-04	7	58	2	PF03637
Domain	MOB_kinase_act_fam	MOB3C MOB4	1.97e-04	7	58	2	IPR005301
Domain	-	MOB3C MOB4	1.97e-04	7	58	2	1.20.140.30
Domain	Mob1_phocein	MOB3C MOB4	1.97e-04	7	58	2	SM01388
Domain	JmjN	KDM5C KDM5D	4.20e-04	10	58	2	SM00545
Domain	JMJN	KDM5C KDM5D	4.20e-04	10	58	2	PS51183
Domain	JmjN	KDM5C KDM5D	4.20e-04	10	58	2	PF02375
Domain	JmjN	KDM5C KDM5D	4.20e-04	10	58	2	IPR003349
Domain	-	KDM5C KDM5D	9.70e-04	15	58	2	1.10.150.60
Domain	BRIGHT	KDM5C KDM5D	9.70e-04	15	58	2	SM00501
Domain	ARID_dom	KDM5C KDM5D	9.70e-04	15	58	2	IPR001606
Domain	ARID	KDM5C KDM5D	9.70e-04	15	58	2	PS51011
Domain	ARID	KDM5C KDM5D	9.70e-04	15	58	2	PF01388
Domain	JmjC	KDM5C KDM5D	2.50e-03	24	58	2	PF02373
Domain	JMJC	KDM5C KDM5D	4.43e-03	32	58	2	PS51184
Domain	JmjC_dom	KDM5C KDM5D	4.43e-03	32	58	2	IPR003347
Domain	JmjC	KDM5C KDM5D	4.70e-03	33	58	2	SM00558
Pubmed	Differential localization of Mox-1 and Mox-2 proteins indicates distinct roles during development.	MEOX1 MEOX2	2.93e-06	2	60	2	9032023
Pubmed	Mouse H-Y encoding Smcy gene and its X chromosomal homolog Smcx.	KDM5C KDM5D	2.93e-06	2	60	2	10441747
Pubmed	Analysis of the cytoprotective role of α-crystallins in cell survival and implication of the αA-crystallin C-terminal extension domain in preventing Bax-induced apoptosis.	CRYAA RPE65	2.93e-06	2	60	2	23383327
Pubmed	Inefficient purifying selection: the mammalian Y chromosome in the rodent genus Mus.	KDM5C KDM5D	2.93e-06	2	60	2	16416087
Pubmed	Mutations of histone demethylase genes encoded by X and Y chromosomes, Kdm5c and Kdm5d, lead to noncompaction cardiomyopathy in mice.	KDM5C KDM5D	2.93e-06	2	60	2	32081420
Pubmed	The single amphioxus Mox gene: insights into the functional evolution of Mox genes, somites, and the asymmetry of amphioxus somitogenesis.	MEOX1 MEOX2	2.93e-06	2	60	2	12051829
Pubmed	Analysis of mutation rates in the SMCY/SMCX genes shows that mammalian evolution is male driven.	KDM5C KDM5D	2.93e-06	2	60	2	9060413
Pubmed	A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens.	KDM5C KDM5D	2.93e-06	2	60	2	7524912
Pubmed	Expression analysis of thirty one Y chromosome genes in human prostate cancer.	TSPY1 KDM5D	8.77e-06	3	60	2	10747295
Pubmed	Identification of a mouse male-specific transplantation antigen, H-Y.	KDM5C KDM5D	8.77e-06	3	60	2	7544442
Pubmed	An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system.	GPR27 GPR85	8.77e-06	3	60	2	10833454
Pubmed	Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors.	MEOX1 MEOX2	1.75e-05	4	60	2	11423130
Pubmed	Novel JARID1C/SMCX mutations in patients with X-linked mental retardation.	KDM5C KDM5D	1.75e-05	4	60	2	16541399
Pubmed	Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent kinase inhibitors p21 and p16 in vascular endothelial cells.	MEOX1 MEOX2	1.75e-05	4	60	2	22206000
Pubmed	The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases.	KDM5C KDM5D	1.75e-05	4	60	2	17320160
Pubmed	Transient activation of meox1 is an early component of the gene regulatory network downstream of hoxa2.	MEOX1 MEOX2	1.75e-05	4	60	2	21245383
Pubmed	Mox-1 and Mox-2 define a novel homeobox gene subfamily and are differentially expressed during early mesodermal patterning in mouse embryos.	MEOX1 MEOX2	1.75e-05	4	60	2	1363541
Pubmed	X- and Y-Linked Chromatin-Modifying Genes as Regulators of Sex-Specific Cancer Incidence and Prognosis.	KDM5C KDM5D	1.75e-05	4	60	2	32732223
Pubmed	A novel X gene with a widely transcribed Y-linked homologue escapes X-inactivation in mouse and human.	KDM5C KDM5D	1.75e-05	4	60	2	7951230
Pubmed	Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.	KDM5C KDM5D EP300	2.57e-05	33	60	3	26864203
Pubmed	Meox homeodomain proteins are required for Bapx1 expression in the sclerotome and activate its transcription by direct binding to its promoter.	MEOX1 MEOX2	2.92e-05	5	60	2	15024065
Pubmed	Distinct embryonic expression and localization of CBP and p300 histone acetyltransferases at the mouse alphaA-crystallin locus in lens.	CRYAA EP300	2.92e-05	5	60	2	17467007
Pubmed	Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription.	TAF15 EP300	4.37e-05	6	60	2	18509338
Pubmed	A dual fate of the hindlimb muscle mass: cloacal/perineal musculature develops from leg muscle cells.	MEOX1 MEOX2	4.37e-05	6	60	2	15653949
Pubmed	Pax1 and Pax9 activate Bapx1 to induce chondrogenic differentiation in the sclerotome.	MEOX1 MEOX2	4.37e-05	6	60	2	12490554
Pubmed	Mox2 is a component of the genetic hierarchy controlling limb muscle development.	MEOX1 MEOX2	6.11e-05	7	60	2	10403250
Pubmed	Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.	JAK2 MEOX2	6.11e-05	7	60	2	31886826
Pubmed	Molecular characterization of human homologs of yeast MOB1.	MOB3C MOB4	8.14e-05	8	60	2	19739119
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	ZNF137P IKZF2 KDM5C KDM5D ZBTB1 EP300 MEOX1 MEOX2	1.27e-04	877	60	8	20211142
Pubmed	New nomenclature for chromatin-modifying enzymes.	KDM5C KDM5D EP300	1.34e-04	57	60	3	18022353
Pubmed	Histone posttranslational modifications and cell fate determination: lens induction requires the lysine acetyltransferases CBP and p300.	CRYAA EP300	1.59e-04	11	60	2	24038357
Pubmed	Fgfr1 regulates development through the combinatorial use of signaling proteins.	MEOX1 MEOX2	1.91e-04	12	60	2	26341559
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	ARHGDIG GPR17 KCNJ6 MC2R R3HDM1 ANO8 PIGM	1.94e-04	697	60	7	28298427
Pubmed	Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches.	KDM5C KDM5D	2.26e-04	13	60	2	14660691
Pubmed	Anterior visceral endoderm SMAD4 signaling specifies anterior embryonic patterning and head induction in mice.	MEOX1 MEOX2	2.26e-04	13	60	2	20941375
Pubmed	Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development.	KDM5C KDM5D	2.26e-04	13	60	2	24619213
Pubmed	The concerted action of Meox homeobox genes is required upstream of genetic pathways essential for the formation, patterning and differentiation of somites.	MEOX1 MEOX2	3.03e-04	15	60	2	12925591
Pubmed	Lack of the mesodermal homeodomain protein MEOX1 disrupts sclerotome polarity and leads to a remodeling of the cranio-cervical joints of the axial skeleton.	MEOX1 MEOX2	3.03e-04	15	60	2	19520072
Pubmed	Antagonist Xist and Tsix co-transcription during mouse oogenesis and maternal Xist expression during pre-implantation development calls into question the nature of the maternal imprint on the X chromosome.	KDM5C BMP15	3.03e-04	15	60	2	26267271
Pubmed	Evolutionary strata on the mouse X chromosome correspond to strata on the human X chromosome.	KDM5C KDM5D	3.03e-04	15	60	2	14762062
Pubmed	Fat4-Dchs1 signalling controls cell proliferation in developing vertebrae.	MEOX1 MEOX2	3.46e-04	16	60	2	27381226
Pubmed	EDAG positively regulates erythroid differentiation and modifies GATA1 acetylation through recruiting p300.	ZBTB1 EP300	4.40e-04	18	60	2	24740910
Pubmed	Sex differences in sex chromosome gene expression in mouse brain.	KDM5C KDM5D	4.40e-04	18	60	2	12023983
Pubmed	FGF signaling regulates development by processes beyond canonical pathways.	MEOX1 MEOX2	4.91e-04	19	60	2	33184218
Pubmed	BMP signaling in the epiblast is required for proper recruitment of the prospective paraxial mesoderm and development of the somites.	MEOX1 MEOX2	5.45e-04	20	60	2	16943278
Pubmed	BAC contig from a 3-cM region of mouse chromosome 11 surrounding Brca1.	HSD17B1 MEOX1	6.02e-04	21	60	2	11013085
Pubmed	Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.	IKZF2 ZBTB1 MEOX1 MEOX2 LARGE1	6.52e-04	402	60	5	24722188
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	AGO3 CACHD1 ANO8	7.21e-04	101	60	3	10997877
Pubmed	The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes.	TSPY10 TSPY8 TSPY1 KDM5D	8.09e-04	241	60	4	12815422
Pubmed	Leber Congenital Amaurosis / Early-Onset Severe Retinal Dystrophy Overview	IFT140 RPE65	8.56e-04	25	60	2	30285347
Pubmed	Diverse Fgfr1 signaling pathways and endocytic trafficking regulate mesoderm development.	MEOX1 MEOX2	8.56e-04	25	60	2	38834239
Pubmed	Muscle developmental defects in heterogeneous nuclear Ribonucleoprotein A1 knockout mice.	MEOX1 MEOX2	1.23e-03	30	60	2	28077597
Pubmed	Mutagenesis of diploid mammalian genes by gene entrapment.	NUDT19 AGO3 CDK5RAP1	1.34e-03	125	60	3	17062627
Pubmed	High-resolution recombinational map of mouse chromosome 16.	KCNJ6 PRM2	1.49e-03	33	60	2	9244437
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	IFT140 CACHD1 MEGF10	1.49e-03	130	60	3	12421765
Interaction	TSPY8 interactions	TSPY3 TSPY2 TSPY8	2.51e-08	3	60	3	int:TSPY8
Cytoband	Yp11.2	TSPY3 TSPY10 TSPY2 TSPY8 TSPY1	1.61e-07	94	60	5	Yp11.2
Cytoband	Ensembl 112 genes in cytogenetic band chrYp11	TSPY3 TSPY10 TSPY2 TSPY8 TSPY1	1.65e-06	150	60	5	chrYp11
Cytoband	Ensembl 112 genes in cytogenetic band chr16p13	IFT140 ARHGDIG RAB26 PRM2	2.37e-03	426	60	4	chr16p13
Cytoband	16p13.3	IFT140 ARHGDIG RAB26	4.06e-03	244	60	3	16p13.3
GeneFamily	MOB kinase activators\|STRIPAK complex	MOB3C MOB4	1.05e-04	7	41	2	647
GeneFamily	AT-rich interaction domain containing	KDM5C KDM5D	5.17e-04	15	41	2	418
GeneFamily	G protein-coupled receptors, Class A orphans	GPR17 GPR27 GPR85	7.32e-04	78	41	3	262
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM5C KDM5D	1.34e-03	24	41	2	485
GeneFamily	HOXL subclass homeoboxes	MEOX1 MEOX2	6.19e-03	52	41	2	518
Coexpression	GSE17721_0.5H_VS_8H_GARDIQUIMOD_BMDC_DN	JAK2 FICD GPR85 PRKRIP1 KDM5D ZBTB1	5.18e-06	199	58	6	M4142
ToppCell	facs-Pancreas-Exocrine-18m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGDIG CACHD1 ORAI2 RAB26 ADAP2	3.75e-06	174	60	5	165e14cad57e90aa247dcecfaa3c2e8ff2a470ad
ToppCell	facs-Pancreas-Exocrine-18m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGDIG CACHD1 ORAI2 RAB26 ADAP2	3.75e-06	174	60	5	4289dfc7613db4bb3d706b9b65d06e84c0c53558
Disease	syndromic X-linked intellectual disability Claes-Jensen type (implicated_via_orthology)	KDM5C KDM5D	1.89e-05	4	53	2	DOID:0060809 (implicated_via_orthology)
Disease	Precursor Cell Lymphoblastic Leukemia Lymphoma	JAK2 IKZF2 EP300	1.83e-04	61	53	3	C1961102
Disease	mitochondrial DNA measurement	COPB1 ZFPM1 PRKRIP1 ANO8 ADAP2	3.05e-04	328	53	5	EFO_0006312
Disease	amenorrhea, response to antineoplastic agent	ADCY8 DERA	3.27e-04	15	53	2	EFO_0010269, GO_0097327
Disease	syndromic intellectual disability (implicated_via_orthology)	KDM5C KDM5D	3.74e-04	16	53	2	DOID:0050888 (implicated_via_orthology)
Disease	heart disease (biomarker_via_orthology)	JAK2 EP300	4.23e-04	17	53	2	DOID:114 (biomarker_via_orthology)
Disease	Deep Vein Thrombosis	JAK2 PIGM	6.50e-04	21	53	2	C0149871
Disease	coronary atherosclerosis measurement, traffic air pollution measurement	FCAMR MEGF10	6.50e-04	21	53	2	EFO_0007908, EFO_0007938
Disease	Venous Thrombosis	JAK2 PIGM	6.50e-04	21	53	2	C0042487
Disease	Leber Congenital Amaurosis	IFT140 RPE65	7.15e-04	22	53	2	C0339527
Disease	Myeloid Leukemia, Chronic	JAK2 SETBP1	1.25e-03	29	53	2	C0023473

Protein segments in the cluster

Peptide	Gene	Start	Entry
QFHRIYIHRYENVSI	ADCY8	401	P40145
RRVYISYLDSVHFFR	EP300	1391	Q09472
VNRSVYVLHYRSHGA	GPR17	281	Q13304
VLAVYAYRHQIHRRS	CACHD1	1111	Q5VU97
YAHLVAFRARYHLVD	AGO3	806	Q9H9G7
TYRRDGHTRNLFVYH	ADAP2	201	Q9NPF8
HRHTRAYAFFVTATY	ANO8	101	Q9HCE9
TSYHRMLLHRVAAYF	R3HDM1	196	Q15032
YSHHTQDDRRDVSRY	TAF15	156	Q92804
FRSVTHAYYRDAHAL	RAB26	126	Q9ULW5
ESTRHNVLYRIRFYF	JAK2	106	O60674
AHHNYLTRLRRYEIA	MEOX1	191	P50221
FVVFTIHFYRSLVRH	ORAI2	211	Q96SN7
RHRVSYRTAYRHGEK	MEGF10	71	Q96KG7
IMYYHVQRHYRASSR	ABCC10	1076	Q5T3U5
FRRERFTVHRTHLYF	LARGE1	446	O95461
RIVTYHRHLYDIHVT	NUDT19	341	A8MXV4
HHGNVRETYRYLTDI	KCNJ6	66	P48051
RRVMEETYYHHIYHT	FICD	216	Q9BVA6
EHYRRLRRYCVFSHE	KDM5D	621	Q9BY66
GLYQLVRATVVYRHH	BMP15	126	O95972
VGVTRYLAIAHHRFY	GPR27	116	Q9NS67
YLAIAHHRFYAERLA	GPR27	121	Q9NS67
HHLVRFYFLTRVYSD	PCED1B	86	Q96HM7
HRHSYVRRNAVLAIY	COPB1	146	P53618
RFSRHETYTVHKRYY	ZFPM1	691	Q8IX07
FAHHNYLTRLRRYEI	MEOX2	206	P50222
AERVRYYREFHHQTA	ASIC3	61	Q9UHC3
YRSQDRYEFSSHIVR	IKZF2	506	Q9UKS7
SGEFHVYRHLRRREY	PRKRIP1	76	Q9H875
VSTNQYTHHRYRDRV	FCAMR	111	Q8WWV6
YTHHRYRDRVALTDF	FCAMR	116	Q8WWV6
HHTYRRGLRVDKTVY	ARHGDIG	151	Q99819
DRTDIHTFHRFYQYL	HSD17B1	206	P14061
YVSRYHVKDSSRHVI	EIF3D	451	O15371
SVTRYLAIAHHRFYT	GPR85	116	P60893
DHGYISREFHRRYRL	CRYAA	106	P02489
DIERQIYHHVTGRYA	DERA	296	Q9Y315
HYYELARDHFSLVRI	IFT140	976	Q96RY7
LSALSVRRQYRLHHY	CYP4F22	236	Q6NT55
TRLFRVFVHVYIHHF	MOB3C	156	Q70IA8
HVTYHRRFIRTDAYV	RPE65	76	Q16518
RRIYRIFSHAYFHHR	MOB4	161	Q9Y3A3
YYVVAVVRRDSSHAF	MELTF	451	P08582
ADRYITIFHALRYHS	MC2R	126	Q01718
GYSREAYVELVHHIR	CDK5RAP1	416	Q96SZ6
VEVYERTHGQSHYRR	PRM2	41	P04554
YEVEAYRRRHHNSSL	TSPY10	241	P0CW01
YEVEAYRRRHHNSSL	TSPY2	241	A6NKD2
YEVEAYRRRHHNSSL	TSPY1	241	Q01534
FREHIQRRHRFSYDT	RNF114	191	Q9Y508
QVHVRDHSGRRAYQY	SOWAHA	411	Q2M3V2
YTERAVFRYHVQREA	VPS18	381	Q9P253
HRSYLAVYQRTHTGE	ZNF137P	111	P52743
FRYYQTFQIHERTHT	ZNF709	261	Q8N972
YEVEAYRRRHHNSSL	TSPY3	241	P0CV98
YEVEAYRRRHHNSSL	TSPY8	241	P0CW00
RHLYQNTRSYHRIVD	ZBTB1	241	Q9Y2K1
VFRISHRSYTFYHEN	SETBP1	966	Q9Y6X0
HTYFYHLTRRDIRHN	PIGM	256	Q9H3S5
RHVRTRLYFTSESHV	PPIP5K1	831	Q6PFW1
EHYRRLRRYCVFSHE	KDM5C	631	P41229