Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	BMP receptor binding	BMP5 BMP6 BMP7	8.78e-06	13	64	3	GO:0070700
GeneOntologyMolecularFunction	transmembrane receptor protein serine/threonine kinase binding	BMP5 BMP6 BMP7	8.69e-05	27	64	3	GO:0070696
GeneOntologyMolecularFunction	receptor serine/threonine kinase binding	BMP5 BMP6 BMP7	1.91e-04	35	64	3	GO:0033612
GeneOntologyMolecularFunction	growth factor activity	BMP5 BMP6 BMP7 BMP8B BMP8A	2.32e-04	173	64	5	GO:0008083
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF708 TBX3 CEBPA ZFP3 ZNF280D AHR ZNF398 ZNF479 CC2D1A ZNF396 ZNF679 SP110 TCFL5	4.60e-04	1412	64	13	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF708 TBX3 CEBPA ZFP3 ZNF280D AHR ZNF479 CC2D1A ZNF396 ZNF679 ZNF501 TCFL5	5.20e-04	1244	64	12	GO:0000978
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF708 TBX3 CEBPA ZFP3 ZNF280D AHR ZNF398 ZNF479 CC2D1A ZNF396 ZNF679 ZNF501 TCFL5	6.28e-04	1459	64	13	GO:0000977
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF708 TBX3 CEBPA ZFP3 ZNF280D AHR ZNF479 CC2D1A ZNF396 ZNF679 ZNF501 TCFL5	6.30e-04	1271	64	12	GO:0000987
GeneOntologyMolecularFunction	cytokine activity	BMP5 BMP6 BMP7 BMP8B BMP8A	1.23e-03	250	64	5	GO:0005125
GeneOntologyMolecularFunction	heat shock protein binding	SLC18A2 AHR METTL22 HTT	1.86e-03	163	64	4	GO:0031072
GeneOntologyBiologicalProcess	neural fold elevation formation	BMP5 BMP7	3.02e-05	3	66	2	GO:0021502
GeneOntologyBiologicalProcess	mesenchyme morphogenesis	BMP5 TBX3 BMP7 HTT	5.59e-05	65	66	4	GO:0072132
GeneOntologyBiologicalProcess	allantois development	BMP5 BMP7	6.03e-05	4	66	2	GO:1905069
GeneOntologyBiologicalProcess	male genitalia development	BMP5 BMP6 TBX3	7.72e-05	26	66	3	GO:0030539
MousePheno	increased circulating tyrosine level	FAH CEBPA	3.46e-05	3	48	2	MP:0013723
MousePheno	epididymis epithelium degeneration	BMP8B BMP8A	3.46e-05	3	48	2	MP:0004934
Domain	TGFb_propeptide	BMP5 BMP6 BMP7 BMP8B BMP8A	4.03e-08	28	65	5	PF00688
Domain	TGF-b_N	BMP5 BMP6 BMP7 BMP8B BMP8A	4.03e-08	28	65	5	IPR001111
Domain	TGF-beta-rel	BMP5 BMP6 BMP7 BMP8B BMP8A	8.17e-08	32	65	5	IPR015615
Domain	TGFb_CS	BMP5 BMP6 BMP7 BMP8B BMP8A	8.17e-08	32	65	5	IPR017948
Domain	TGFB	BMP5 BMP6 BMP7 BMP8B BMP8A	1.75e-07	37	65	5	SM00204
Domain	TGF-b_C	BMP5 BMP6 BMP7 BMP8B BMP8A	1.75e-07	37	65	5	IPR001839
Domain	TGF_BETA_2	BMP5 BMP6 BMP7 BMP8B BMP8A	1.75e-07	37	65	5	PS51362
Domain	TGF_beta	BMP5 BMP6 BMP7 BMP8B BMP8A	1.75e-07	37	65	5	PF00019
Domain	TGF_BETA_1	BMP5 BMP6 BMP7 BMP8B BMP8A	1.75e-07	37	65	5	PS00250
Domain	-	BMP5 BMP6 BMP7 BMP8B BMP8A	3.57e-06	67	65	5	2.10.90.10
Domain	Cystine-knot_cytokine	BMP5 BMP6 BMP7 BMP8B BMP8A	3.57e-06	67	65	5	IPR029034
Domain	ZINC_FINGER_C2H2_2	ZNF708 ZFP3 ZNF280D ZNF804B ZNF398 ZNF479 ZNF396 FAM170A ZNF679 ZNF501	3.23e-04	775	65	10	PS50157
Domain	Gprotein_alpha_I	GNAT3 GNAT2	3.29e-04	8	65	2	IPR001408
Domain	ZINC_FINGER_C2H2_1	ZNF708 ZFP3 ZNF280D ZNF804B ZNF398 ZNF479 ZNF396 FAM170A ZNF679 ZNF501	3.30e-04	777	65	10	PS00028
Domain	Znf_C2H2-like	ZNF708 ZFP3 ZNF280D ZNF804B ZNF398 ZNF479 ZNF396 FAM170A ZNF679 ZNF501	3.99e-04	796	65	10	IPR015880
Domain	ZnF_C2H2	ZNF708 ZFP3 ZNF280D ZNF804B ZNF398 ZNF479 ZNF396 FAM170A ZNF679 ZNF501	4.49e-04	808	65	10	SM00355
Domain	Inhibin_asu	BMP8B BMP8A	9.08e-04	13	65	2	IPR002405
Domain	G-alpha	GNAT3 GNAT2	1.39e-03	16	65	2	PF00503
Domain	GproteinA_insert	GNAT3 GNAT2	1.39e-03	16	65	2	IPR011025
Domain	-	GNAT3 GNAT2	1.39e-03	16	65	2	1.10.400.10
Domain	G_alpha	GNAT3 GNAT2	1.39e-03	16	65	2	SM00275
Domain	Gprotein_alpha_su	GNAT3 GNAT2	1.57e-03	17	65	2	IPR001019
Domain	Znf_C2H2	ZNF708 ZFP3 ZNF280D ZNF804B ZNF398 ZNF479 ZNF396 ZNF679 ZNF501	1.80e-03	805	65	9	IPR007087
Domain	zf-C2H2	ZNF708 ZFP3 ZNF280D ZNF398 ZNF479 ZNF396 ZNF679 ZNF501	2.69e-03	693	65	8	PF00096
Domain	-	ZNF708 ZFP3 ZNF398 ZNF479 ZNF396 ZNF679 ZNF501	9.12e-03	679	65	7	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZNF708 ZFP3 ZNF398 ZNF479 ZNF396 ZNF679 ZNF501	1.02e-02	694	65	7	IPR013087
Pathway	KEGG_MEDICUS_REFERENCE_BMP_SIGNALING_PATHWAY_BMP_ANTAGONIST	BMP5 BMP6 BMP7 BMP8B BMP8A	1.08e-09	15	48	5	M47824
Pathway	KEGG_MEDICUS_REFERENCE_BMP_SIGNALING_PATHWAY	BMP5 BMP6 BMP7 BMP8B BMP8A	5.51e-09	20	48	5	M47843
Pathway	KEGG_HEDGEHOG_SIGNALING_PATHWAY	BMP5 BMP6 BMP7 BMP8B BMP8A	1.24e-06	56	48	5	M1053
Pathway	KEGG_TGF_BETA_SIGNALING_PATHWAY	BMP5 BMP6 BMP7 BMP8B BMP8A	1.05e-05	86	48	5	M2642
Pubmed	Colocalization of BMP 7 and BMP 2 RNAs suggests that these factors cooperatively mediate tissue interactions during murine development.	BMP5 BMP6 BMP7 BMP8B BMP8A	1.26e-13	6	66	5	7605753
Pubmed	Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis.	BMP5 BMP6 BMP7 BMP8B BMP8A	2.64e-12	9	66	5	1460021
Pubmed	Bmp7 regulates germ cell proliferation in mouse fetal gonads.	BMP5 BMP6 BMP7 BMP8B BMP8A	2.68e-11	13	66	5	18391523
Pubmed	Bone Morphogenetic Protein (BMP) signaling in development and human diseases.	BMP5 BMP6 BMP8B	6.53e-09	3	66	3	25401122
Pubmed	Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone.	BMP5 BMP6 BMP7	6.53e-09	3	66	3	2263636
Pubmed	A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7.	BMP5 BMP6 BMP7	6.53e-09	3	66	3	1427904
Pubmed	Mutation in Bmp7 exacerbates the phenotype of Bmp8a mutants in spermatogenesis and epididymis.	BMP7 BMP8B BMP8A	6.53e-09	3	66	3	11784057
Pubmed	Dysfunction of programmed embryo senescence is linked to genetic developmental defects.	BMP5 BMP7 BMP8B BMP8A	3.55e-08	18	66	4	37017267
Pubmed	Expression of bone morphogenetic proteins in human metastatic prostate and breast cancer.	BMP5 BMP6 BMP7	6.51e-08	5	66	3	15861517
Pubmed	Erythroferrone inhibits the induction of hepcidin by BMP6.	BMP5 BMP6 BMP7	6.51e-08	5	66	3	30097509
Pubmed	TGFbeta superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population.	BMP5 BMP6 BMP7 BMP8B BMP8A	6.82e-08	55	66	5	15342483
Pubmed	Bone morphogenetic protein signaling in the developing kidney: present and future.	BMP5 BMP6 BMP7	1.30e-07	6	66	3	18331343
Pubmed	Osteocyte control of bone formation via sclerostin, a novel BMP antagonist.	BMP5 BMP6 BMP7	1.30e-07	6	66	3	14633986
Pubmed	Expression patterns of bone morphogenetic proteins (Bmps) in the developing mouse tooth suggest roles in morphogenesis and cell differentiation.	BMP5 BMP6 BMP7	1.30e-07	6	66	3	9415424
Pubmed	Overlapping expression domains of bone morphogenetic protein family members potentially account for limited tissue defects in BMP7 deficient embryos.	BMP5 BMP6 BMP7	1.30e-07	6	66	3	9056639
Pubmed	Expression and misexpression of members of the FGF and TGFbeta families of growth factors in the developing mouse pancreas.	BMP5 BMP6 BMP7 BMP8B BMP8A	1.72e-07	66	66	5	12666204
Pubmed	Deletion of Lrp4 increases the incidence of microphthalmia.	BMP5 BMP6 BMP7 BMP8B BMP8A	2.16e-07	69	66	5	30352686
Pubmed	Neuronal differentiation of precursors in the neocortical ventricular zone is triggered by BMP.	BMP5 BMP6 BMP7	2.27e-07	7	66	3	9786991
Pubmed	Limbiting outgrowth: BMPs as negative regulators in limb development.	BMP5 BMP6 BMP7	2.27e-07	7	66	3	10462412
Pubmed	BMP7 functions predominantly as a heterodimer with BMP2 or BMP4 during mammalian embryogenesis.	BMP5 BMP6 BMP7	2.27e-07	7	66	3	31566563
Pubmed	A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4.	BMP5 BMP6 BMP7	2.27e-07	7	66	3	7811286
Pubmed	Mice lacking Bmp6 function.	BMP5 BMP6 BMP7	3.63e-07	8	66	3	9664685
Pubmed	The enamel knot as a signaling center in the developing mouse tooth.	BMP5 BMP6 BMP7	3.63e-07	8	66	3	8808404
Pubmed	Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development.	BMP5 BMP6 BMP7	3.63e-07	8	66	3	9187146
Pubmed	A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage.	BMP5 BMP6 BMP7	5.44e-07	9	66	3	14660436
Pubmed	Exploring the effects of gene dosage on mandible shape in mice as a model for studying the genetic basis of natural variation.	BMP5 BMP6 BMP7	5.44e-07	9	66	3	23563729
Pubmed	Myocardial β-Catenin-BMP2 signaling promotes mesenchymal cell proliferation during endocardial cushion formation.	BMP5 BMP6 TBX3 BMP7	8.32e-07	38	66	4	30201295
Pubmed	Apoptosis, proliferation and gene expression patterns in mouse developing tongue.	BMP5 BMP6 BMP7	1.84e-06	13	66	3	16151852
Pubmed	Cardiac outflow tract defects in mice lacking ALK2 in neural crest cells.	BMP5 BMP6 BMP7	2.92e-06	15	66	3	15226263
Pubmed	Human BMP8A suppresses luteinization of rat granulosa cells via the SMAD1/5/8 pathway.	BMP8B BMP8A	3.55e-06	2	66	2	31940275
Pubmed	Is CCAAT/enhancer-binding protein a central regulator of energy metabolism?	FAH CEBPA	3.55e-06	2	66	2	2697636
Pubmed	Bone morphogenetic protein 8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis.	BMP8B BMP8A	3.55e-06	2	66	2	9463357
Pubmed	The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse.	BMP8B BMP8A	3.55e-06	2	66	2	8682296
Pubmed	Bone morphogenetic proteins inhibit CD40L/IL-21-induced Ig production in human B cells: differential effects of BMP-6 and BMP-7.	BMP6 BMP7	3.55e-06	2	66	2	21898381
Pubmed	Polo-like kinase 1 expression is suppressed by CCAAT/enhancer-binding protein α to mediate colon carcinoma cell differentiation and apoptosis.	CEBPA PLK1	3.55e-06	2	66	2	28341486
Pubmed	Murine osteogenic protein (OP-1): high levels of mRNA in kidney.	BMP6 BMP7	3.55e-06	2	66	2	1715687
Pubmed	Dysregulation of C/EBPalpha by mutant Huntingtin causes the urea cycle deficiency in Huntington's disease.	CEBPA HTT	3.55e-06	2	66	2	17213233
Pubmed	The protective role of bone morphogenetic protein-8 in the glucocorticoid-induced apoptosis on bone cells.	BMP8B BMP8A	3.55e-06	2	66	2	21277400
Pubmed	Interaction between gonadotropin-releasing hormone and bone morphogenetic protein-6 and -7 signaling in LβT2 gonadotrope cells.	BMP6 BMP7	3.55e-06	2	66	2	21846488
Pubmed	Bmp5/7 in concert with the mid-hindbrain organizer control development of noradrenergic locus coeruleus neurons.	BMP5 BMP6 BMP7	3.59e-06	16	66	3	20493948
Pubmed	Neural plate morphogenesis during mouse neurulation is regulated by antagonism of Bmp signalling.	BMP5 BMP6 BMP7	4.35e-06	17	66	3	17693602
Pubmed	Bmp7 regulates the survival, proliferation, and neurogenic properties of neural progenitor cells during corticogenesis in the mouse.	BMP5 BMP6 BMP7	4.35e-06	17	66	3	22461901
Pubmed	Dragon (repulsive guidance molecule b) inhibits IL-6 expression in macrophages.	BMP5 BMP6 BMP7	6.19e-06	19	66	3	21187450
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MON2 BMP8B TRIB3 BTBD7 CTDP1 HECTD4 SHC1 MED14 ZNF398 CC2D1A HTT	6.87e-06	1105	66	11	35748872
Pubmed	Primordial germ cell proliferation is impaired in Fused Toes mutant embryos.	BMP5 BMP6 BMP7	9.80e-06	22	66	3	20969841
Pubmed	T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis.	BMP5 TBX3 BMP7	9.80e-06	22	66	3	15843407
Pubmed	Bone morphogenetic proteins are overexpressed in the bone marrow of primary myelofibrosis and are apparently induced by fibrogenic cytokines.	BMP6 BMP7	1.06e-05	3	66	2	18349123
Pubmed	BMP4 substitutes for loss of BMP7 during kidney development.	BMP6 BMP7	1.06e-05	3	66	2	16154126
Pubmed	Evidence that Mothers-against-dpp-related 1 (Madr1) plays a role in the initiation and maintenance of spermatogenesis in the mouse.	BMP8B BMP8A	1.06e-05	3	66	2	9076678
Pubmed	BMP7 Induces Uterine Receptivity and Blastocyst Attachment.	BMP5 BMP7	1.06e-05	3	66	2	28324064
Pubmed	Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs).	BMP8B BMP8A	1.06e-05	3	66	2	12925636
Pubmed	Bone morphogenetic proteins promote development of fetal pancreas epithelial colonies containing insulin-positive cells.	BMP5 BMP6	1.06e-05	3	66	2	11865031
Pubmed	Bone morphogenetic protein-2, -6, and -7 differently regulate osteogenic differentiation of human periodontal ligament stem cells.	BMP6 BMP7	1.06e-05	3	66	2	23853066
Pubmed	Bone morphogenetic proteins 4, 6, and 7 are up-regulated in mouse spinal cord during experimental autoimmune encephalomyelitis.	BMP6 BMP7	1.06e-05	3	66	2	17722066
Pubmed	Requirement of Bmp8b for the generation of primordial germ cells in the mouse.	BMP8B BMP8A	1.06e-05	3	66	2	10894154
Pubmed	Growth differentiation factor 3 is induced by bone morphogenetic protein 6 (BMP-6) and BMP-7 and increases luteinizing hormone receptor messenger RNA expression in human granulosa cells.	BMP6 BMP7	1.06e-05	3	66	2	22305102
Pubmed	Synergistic effects of BMP-2, BMP-6 or BMP-7 with human plasma fibronectin onto hydroxyapatite coatings: A comparative study.	BMP6 BMP7	1.06e-05	3	66	2	28434979
Pubmed	BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions.	BMP8B BMP8A	1.06e-05	3	66	2	22579288
Pubmed	Immunohistochemical analysis revealed the expression of bone morphogenetic proteins-4, 6, 7, and 9 in human induced membrane samples treated with the Masquelet technique.	BMP6 BMP7	1.06e-05	3	66	2	35033126
Pubmed	Estrogen mediated epithelial proliferation in the uterus is directed by stromal Fgf10 and Bmp8a.	BMP8B BMP8A	1.06e-05	3	66	2	25451979
Pubmed	Endocardial to myocardial notch-wnt-bmp axis regulates early heart valve development.	BMP5 BMP6 BMP7	1.46e-05	25	66	3	23560082
Pubmed	IkappaB kinase-alpha acts in the epidermis to control skeletal and craniofacial morphogenesis.	BMP5 BMP6 BMP7	1.64e-05	26	66	3	15071597
Pubmed	Retrograde BMP signaling regulates trigeminal sensory neuron identities and the formation of precise face maps.	BMP6 TBX3 BMP7	2.07e-05	28	66	3	17698011
Pubmed	Skeletal abnormalities in doubly heterozygous Bmp4 and Bmp7 mice.	BMP5 BMP7	2.12e-05	4	66	2	9664686
Pubmed	Intermittent fasting induces rapid hepatocyte proliferation to restore the hepatostat in the mouse liver.	TBX3 GNAT2	2.12e-05	4	66	2	36719070
Pubmed	Characterization and chromosomal localization of PTPRO, a novel receptor protein tyrosine phosphatase, expressed in hematopoietic stem cells.	BMP8B BMP8A	2.12e-05	4	66	2	9434160
Pubmed	Evidence that mouse Bmp8a (Op2) and Bmp8b are duplicated genes that play a role in spermatogenesis and placental development.	BMP8B BMP8A	2.12e-05	4	66	2	8843393
Pubmed	Immunohistochemical localization of bone morphogenetic proteins (BMPs) 2, 4, 6, and 7 during induced heterotopic bone formation.	BMP6 BMP7	2.12e-05	4	66	2	17262821
Pubmed	Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation.	BMP6 BMP7	2.12e-05	4	66	2	17244894
Pubmed	Bone morphogenic factor gene dosage abnormalities in prostatic intraepithelial neoplasia and prostate cancer.	BMP5 BMP7	2.12e-05	4	66	2	17656261
Pubmed	Dominant negative Bmp5 mutation reveals key role of BMPs in skeletal response to mechanical stimulation.	BMP5 BMP6	2.12e-05	4	66	2	18380899
Pubmed	TRIB3 limits FGF21 induction during in vitro and in vivo nutrient deficiencies by inhibiting C/EBP-ATF response elements in the Fgf21 promoter.	CEBPA TRIB3	2.12e-05	4	66	2	29378327
Pubmed	Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia.	CEBPA TRIB3	3.53e-05	5	66	2	20410507
Pubmed	Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot.	BMP6 BMP7	3.53e-05	5	66	2	14623234
Pubmed	Histological development and dynamic expression of Bmp2-6 mRNAs in the embryonic and postnatal mouse cranial base.	BMP5 BMP6	3.53e-05	5	66	2	17066377
Pubmed	Chromosomal localization, embryonic expression, and imprinting tests for Bmp7 on distal mouse chromosome 2.	BMP5 BMP7	3.53e-05	5	66	2	7490098
Pubmed	Bmp6 and Bmp7 are required for cushion formation and septation in the developing mouse heart.	BMP6 BMP7	3.53e-05	5	66	2	11437450
Pubmed	Effect of bone morphogenetic proteins-4, -5 and -6 on DNA synthesis and expression of bone-related proteins in cultured human periodontal ligament cells.	BMP5 BMP6	3.53e-05	5	66	2	15516325
Pubmed	The pseudokinase TRIB1 toggles an intramolecular switch to regulate COP1 nuclear export.	CEBPA TRIB3	3.53e-05	5	66	2	30692133
Pubmed	Genomic organization, expression, and function of bitter taste receptors (T2R) in mouse and rat.	GNAT3 GNAT2	3.53e-05	5	66	2	15886333
Pubmed	Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons.	BMP5 BMP7	3.53e-05	5	66	2	11580864
Pubmed	Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.	BMP5 BMP6 BMP7 BMP8B BMP8A	5.07e-05	210	66	5	16537572
Pubmed	BMP/SMAD Pathway Promotes Neurogenesis of Midbrain Dopaminergic Neurons In Vivo and in Human Induced Pluripotent and Neural Stem Cells.	BMP5 BMP6 BMP7	5.25e-05	38	66	3	29321139
Pubmed	Regulation of ovarian function by the TGF-beta superfamily and follistatin.	BMP6 BMP7	5.29e-05	6	66	2	12887271
Pubmed	Conserved chromosomal location and genomic structure of human and mouse fatty-acid amide hydrolase genes and evaluation of clasper as a candidate neurological mutation.	BMP8B BMP8A	5.29e-05	6	66	2	9878243
Pubmed	Impaired TrkB-mediated ERK1/2 activation in huntington disease knock-in striatal cells involves reduced p52/p46 Shc expression.	SHC1 HTT	5.29e-05	6	66	2	20442398
Pubmed	Effect of BMPs and Wnt3a co-expression on the osteogenetic capacity of osteoblasts.	BMP6 BMP7	5.29e-05	6	66	2	27633082
Pubmed	BMP mRNA and protein expression in the developing mouse olfactory system.	BMP6 BMP7	5.29e-05	6	66	2	12210138
Pubmed	Notch-Rbpj signaling is required for the development of noradrenergic neurons in the mouse locus coeruleus.	BMP5 BMP6 BMP7	6.13e-05	40	66	3	22718343
Pubmed	Epidemiology of the antibiotic resistance of Helicobacter pylori in Canada.	WAPL PLK1	7.40e-05	7	66	2	11111111
Pubmed	Type I receptor binding of bone morphogenetic protein 6 is dependent on N-glycosylation of the ligand.	BMP6 BMP7	7.40e-05	7	66	2	18070108
Pubmed	Survival of Hoxa13 homozygous mutants reveals a novel role in digit patterning and appendicular skeletal development.	BMP6 BMP7	7.40e-05	7	66	2	20034107
Pubmed	The Bmp8 gene is expressed in developing skeletal tissue and maps near the Achondroplasia locus on mouse chromosome 4.	BMP8B BMP8A	7.40e-05	7	66	2	9070944
Pubmed	Characterisation of the mouse diabetes susceptibilty locus Nidd/SJL: islet cell destruction, interaction with the obesity QTL Nob1, and effect of dietary fat.	BMP8B BMP8A	7.40e-05	7	66	2	12107726
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	MON2 CUL2 WAPL PANK4 MED14 TIMELESS PLK1	9.26e-05	560	66	7	35241646
Pubmed	Direct and indirect roles of CNS dorsal midline cells in choroid plexus epithelia formation.	BMP6 BMP7	9.86e-05	8	66	2	15975937
Pubmed	Genome-wide study reveals an important role of spontaneous autoimmunity, cardiomyocyte differentiation defect and anti-angiogenic activities in gender-specific gene expression in Keshan disease.	BMP5 BMP7	9.86e-05	8	66	2	24384427
Pubmed	BMPER regulates cardiomyocyte size and vessel density in vivo.	BMP5 BMP7	9.86e-05	8	66	2	23200275
Pubmed	Comparative Transcriptomic and Epigenomic Analyses Reveal New Regulators of Murine Brown Adipogenesis.	BMP7 CEBPA	9.86e-05	8	66	2	27923061
Pubmed	Patterning events and specification signals in the developing hippocampus.	BMP6 BMP7	9.86e-05	8	66	2	10498273
Interaction	CHRDL2 interactions	FAH BMP5 BMP6 BMP7	8.25e-06	40	65	4	int:CHRDL2
GeneFamily	Bone morphogenetic proteins\|Astacins	BMP5 BMP6 BMP7 BMP8B BMP8A	3.08e-11	11	44	5	455
GeneFamily	Endogenous ligands	BMP5 BMP6 BMP7 BMP8B BMP8A HTT	2.22e-05	237	44	6	542
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF708 ZFP3 ZNF398 ZNF479 ZNF396 ZNF679 ZNF501	1.61e-03	718	44	7	28
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TBX3 AHR UBR3 CRYBG3 ARAP2	5.23e-06	169	66	5	41ad349806b279fbe1374b7e3cc7f146a11adb44
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TBX3 AHR UBR3 CRYBG3 ARAP2	5.23e-06	169	66	5	42782c61592742190ab0cba8a94f8bdf9c278f90
ToppCell	droplet-Heart-4Chambers-21m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MMRN1 FAH METTL22 DENND3 CYFIP2	8.12e-06	185	66	5	bb5a4cf93534b9bcd0923f314c389d571e91e7f8
ToppCell	facs-Lung-nan-3m-Endothelial-endothelial_cell_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP6 TBX3 DENND3 ADGRL3 ARAP2	1.02e-05	194	66	5	f159ef8541d75a4e98468947f231bb463bec922c
Drug	Meglumine [6284-40-8]; Down 200; 20.4uM; MCF7; HT_HG-U133A	BMP5 AMPD3 FAM222B CC2D1A TMEM222 SP110 CYFIP2	1.60e-06	196	66	7	6445_DN
Drug	haloperidol; Down 200; 10uM; MCF7; HT_HG-U133A_EA	CUL2 BMP7 CEBPA ZNF280D ABCF2 CC2D1A HAUS2	1.71e-06	198	66	7	983_DN
Drug	alpha-D-glucose 1-phosphate 6-vanadate	BMP5 BMP6 BMP7 BMP8B BMP8A	5.71e-06	88	66	5	CID005289552
Drug	AC1L9Q5W	BMP5 BMP6 BMP7 BMP8B BMP8A	1.42e-05	106	66	5	CID000452221
Drug	Astemizole [68844-77-9]; Down 200; 8.8uM; MCF7; HT_HG-U133A	BMP5 BMP7 CEBPA BTBD7 ABCF2 SP110	1.87e-05	190	66	6	6807_DN
Drug	Vitamin K2 [11032-49-8]; Up 200; 9uM; MCF7; HT_HG-U133A	BMP5 TBX3 CC2D1A GNAT2 FAM135A DENND3	2.04e-05	193	66	6	3880_UP
Drug	rottlerin; Down 200; 10uM; MCF7; HT_HG-U133A_EA	CUL2 BMP5 CEBPA CTDP1 ABCF2 SP110	2.36e-05	198	66	6	914_DN
Drug	Acetopromazine maleate salt [3598-37-6]; Up 200; 9uM; PC3; HT_HG-U133A	BMP6 BMP7 SLC18A2 TIMELESS GNAT2 DENND3	2.43e-05	199	66	6	4494_UP
Disease	diabetes mellitus (implicated_via_orthology)	BMP5 BMP6 BMP7 BMP8B BMP8A	2.40e-09	26	63	5	DOID:9351 (implicated_via_orthology)
Disease	obesity (implicated_via_orthology)	BMP5 BMP6 BMP7 BMP8B BMP8A	9.77e-05	215	63	5	DOID:9970 (implicated_via_orthology)
Disease	McCune Albright syndrome (implicated_via_orthology)	GNAT3 GNAT2	1.25e-04	8	63	2	DOID:1858 (implicated_via_orthology)
Disease	Bone Resorption	BMP7 AHR	2.00e-04	10	63	2	C0005974
Disease	Marfan syndrome (implicated_via_orthology)	BMP6 BMP7	2.00e-04	10	63	2	DOID:14323 (implicated_via_orthology)
Disease	1-methylxanthine measurement	AMPD3 AHR	2.44e-04	11	63	2	EFO_0021174
Disease	amygdala volume change measurement	ZNF804B SPATA31C2	5.28e-04	16	63	2	EFO_0021490
Disease	eosinophil count	MON2 CUL2 BMP7 SLAMF6 CEBPA TRIB3 HECTD4 SHC1 AHR ZNF398	1.15e-03	1488	63	10	EFO_0004842
Disease	coffee consumption	HECTD4 AHR	2.14e-03	32	63	2	EFO_0004330
Disease	rheumatoid arthritis, celiac disease	AFF3 HECTD4	2.27e-03	33	63	2	EFO_0000685, EFO_0001060

Protein segments in the cluster

Peptide	Gene	Start	Entry
NMATHLSQHKTHTCQ	ZNF280D	706	Q6N043
ALNSSCMVQEHLHLE	AHR	606	P35869
QMAANHVSITNSILH	AFF3	1156	P51826
QTLIHTTEQHCQQMS	CTDP1	191	Q9Y5B0
DFLNGVCTNIIHMHN	ABCF2	286	Q9UG63
MAQNCEAHTCVFHQS	CRYBG3	956	Q68DQ2
CSCNHLTNFAVLMAH	ADGRL3	836	Q9HAR2
LHVASLTRQLQHCMA	CCNI2	281	Q6ZMN8
QKCSEINHMNAHNLA	ARAP2	1251	Q8WZ64
CQLHSLDLQHSMVES	FBXL6	246	Q8N531
INVHSMSCNKQLTAH	DENND3	971	A2RUS2
MNATNHAIVQTLVHF	BMP7	371	P18075
THIHAAACMNQKHLL	AMPD3	316	Q01432
LNIHMNFTHICRSHN	SLC2A12	366	Q8TD20
NGQMECCQTLVSHHV	ESPNL	281	Q6ZVH7
NRMHESLHLFNSICN	GNAT3	241	A8MTJ3
AQKCHTLQSMNNHLE	HAUS2	86	Q9NVX0
NKTLHEVLTMCHNAS	MMRN1	921	Q13201
AIHPVSMNNSNHLVN	ASAH2	301	Q9NR71
HLHSQLSCSQQSREM	FSIP2	1451	Q5CZC0
ELHAQSHLQMCTAIK	FAM135A	366	Q9P2D6
LQRSQHTQCLMQHEP	FAM205A	541	Q6ZU69
LQRSQHTQCLMQHEP	FAM205BP	271	Q63HN1
NQHQLAHLQQMCSEA	FAM222B	366	Q8WU58
NIQCMRTLLNLAHCH	MON2	676	Q7Z3U7
SMFLANHNRITQCLH	CYFIP2	211	Q96F07
NQLLHHVGAMCIHQL	HECTD4	226	Q9Y4D8
HVGAMCIHQLNLLAT	HECTD4	231	Q9Y4D8
NCHNTILHQLQEMFN	MED14	846	O60244
LHMISNDIGQLACLH	PANK4	296	Q9NVE7
LGHQCFISMSAIVNH	WDPCP	516	O95876
VNIHSQQHVLVMCAT	HTT	2821	P42858
VALMARACNIHHNNS	PDSS1	141	Q5T2R2
LQFQIAHCGQTTMHL	CEBPA	206	P49715
AHMNATNHAIVQTLV	BMP6	451	P22004
CMNATNHAILQSLVH	BMP8A	341	Q7Z5Y6
CQQRMVADHLQFLHA	CUL2	266	Q13617
QHEMCLNHSNQFTQL	CC2D1A	586	Q6P1N0
QCCHMISHQQISSNQ	BTBD7	621	Q9P203
NAHMNATNHAIVQTL	BMP5	391	P22003
MLQQLTHHSVNGCNL	FAH	326	P16930
CMNATNHAILQSLVH	BMP8B	341	P34820
LHNHQATNMIALLTG	DSEL	221	Q8IZU8
HLQQHVLASQGLAMS	TBX3	581	O15119
TNHSQLFQNMTCELH	SLAMF6	136	Q96DU3
NMSLCHARHASKVNQ	SPATA31C2	1066	B4DYI2
NRMHESLHLFNSICN	GNAT2	241	P19087
SMCQRNIALNSHLAA	METTL22	241	Q9BUU2
QQCHHVSKTLERQMQ	SP110	586	Q9HB58
FVLLQAMVHHANSSC	RIG	36	Q13278
NLLVANTHHVSLNMT	VNN2	261	O95498
QNSAHTNHCIVKMLH	TIMELESS	716	Q9UNS1
QDFCHHSCSSQMQQL	ZNF804B	1321	A4D1E1
MFAQLSHLQCLRLSH	TLR9	491	Q9NR96
VLFRQMATALAHCHQ	TRIB3	161	Q96RU7
NLSQDMLLTHQCSHA	ZNF398	351	Q8TD17
KSFCMVSQLHQHQII	ZNF679	191	Q8IYX0
SCHVFHLTMAQLTGN	FAM170A	256	A1A519
QHHQNLSLCTAALMY	WAPL	711	Q7Z5K2
GKSFCMLSHLNQHQV	ZNF479	191	Q96JC4
CDNCHSHVALALNLM	TMEM222	141	Q9H0R3
SFCMLSQLTQHEIIH	ZNF708	176	P17019
RSCLNQLFHVLALHM	UBR3	1481	Q6ZT12
HCNVSNILHMNGSQS	ZNF396	211	Q96N95
LTLHQTATQHMVTNA	SLC18A2	96	Q05940
QLQHILCSHMEAAAD	TCFL5	56	Q9UL49
ADCKQIIANHHMQSI	SHC1	246	P29353
FNQSACLMQHQRIHS	ZNF501	171	Q96CX3
CGKAFNQNSHLIQHM	ZFP3	146	Q96NJ6
DCHLSDMLQQLHSVN	PLK1	371	P53350