Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	peptidyl-tyrosine modification	TPST2 IL12RB2 FLT1 PRKCA PLCG2 TNFRSF1A FBXW7 IFNAR1	1.11e-05	329	67	8	GO:0018212
MousePheno	increased CD8-positive, alpha-beta T cell number	KLHL6 DCLRE1C PLCG2 TNFRSF1A SMCR8 LEPR IFNAR1	1.06e-05	195	55	7	MP:0008078
MousePheno	optic neuropathy	TDRD7 ELP1	1.52e-05	2	55	2	MP:0006222
MousePheno	increased effector memory CD8-positive, alpha-beta T cell number	DCLRE1C PLCG2 TNFRSF1A LEPR	8.31e-05	59	55	4	MP:0010850
MousePheno	increased plasmacytoma incidence	IL12RB2 BECN1	9.07e-05	4	55	2	MP:0010286
Domain	IgC2-like_lig-bd	IL12RB2 LEPR	7.35e-05	4	66	2	IPR010457
Domain	Lep_receptor_Ig	IL12RB2 LEPR	7.35e-05	4	66	2	PF06328
Domain	Hematopoietin_rcpt_Gp130_CS	IL12RB2 LEPR	2.55e-04	7	66	2	IPR003529
Domain	Znf_MYM	ZMYM4 ZMYM6	2.55e-04	7	66	2	IPR010507
Domain	zf-FCS	ZMYM4 ZMYM6	2.55e-04	7	66	2	PF06467
Domain	TRASH_dom	ZMYM4 ZMYM6	3.40e-04	8	66	2	IPR011017
Domain	TRASH	ZMYM4 ZMYM6	3.40e-04	8	66	2	SM00746
Domain	HEMATOPO_REC_L_F2	IL12RB2 LEPR	3.40e-04	8	66	2	PS01353
Domain	Linker_histone	H1-9P HP1BP3	9.36e-04	13	66	2	PF00538
Domain	Histone_H1/H5_H15	H1-9P HP1BP3	1.09e-03	14	66	2	IPR005818
Domain	Lactamase_B	DCLRE1C LACTB2	1.25e-03	15	66	2	SM00849
Domain	-	DCLRE1C LACTB2	2.24e-03	20	66	2	3.60.15.10
Domain	Metallo-B-lactamas	DCLRE1C LACTB2	2.24e-03	20	66	2	IPR001279
Domain	-	IQSEC3 MTMR4 TLN1 PLCG2 FAM43B PHLPP2	2.56e-03	391	66	6	2.30.29.30
Domain	PH_dom-like	IQSEC3 MTMR4 TLN1 PLCG2 FAM43B PHLPP2	3.90e-03	426	66	6	IPR011993
Domain	DEATH	ANK2 TNFRSF1A	4.08e-03	27	66	2	SM00005
Domain	TNFR_NGFR_1	TNFRSF1A TNFRSF17	4.70e-03	29	66	2	PS00652
Domain	TNFR_NGFR_2	TNFRSF1A TNFRSF17	4.70e-03	29	66	2	PS50050
Domain	Death	ANK2 TNFRSF1A	6.05e-03	33	66	2	PF00531
Domain	TNFR/NGFR_Cys_rich_reg	TNFRSF1A TNFRSF17	6.05e-03	33	66	2	IPR001368
Pubmed	Restriction of Legionella pneumophila growth in macrophages requires the concerted action of cytokine and Naip5/Ipaf signalling pathways.	IL12RB2 TNFRSF1A IFNAR1	8.49e-07	10	68	3	17506816
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	UBN1 DSP MYO9A KDM5C ELP1 MORC4 FAM135A ZMYM4 ZMYM6	2.16e-06	588	68	9	38580884
Pubmed	Autophagy Differentially Regulates Insulin Production and Insulin Sensitivity.	BECN1 LEPR	3.77e-06	2	68	2	29898399
Pubmed	Signal 3 requirement for memory CD8+ T-cell activation is determined by the infectious pathogen.	IL12RB2 IFNAR1	3.77e-06	2	68	2	21830209
Pubmed	Modulation of PKC signaling and induction of apoptosis through suppression of reactive oxygen species and tumor necrosis factor receptor 1 (TNFR1): key role of quercetin in cancer prevention.	PRKCA TNFRSF1A	3.77e-06	2	68	2	26076811
Pubmed	Dual Inhibition of TNFR1 and IFNAR1 in Imiquimod-Induced Psoriasiform Skin Inflammation in Mice.	TNFRSF1A IFNAR1	3.77e-06	2	68	2	25911755
Pubmed	Roles of PLC-gamma2 and PKCalpha in TPA-induced apoptosis of gastric cancer cells.	PRKCA PLCG2	3.77e-06	2	68	2	14606067
Pubmed	Loss of mouse Ikbkap, a subunit of elongator, leads to transcriptional deficits and embryonic lethality that can be rescued by human IKBKAP.	FLT1 ELP1 BECN1	9.27e-06	21	68	3	19015235
Pubmed	Rotavirus infection causes mesenteric lymph node hypertrophy independently of type I interferon or TNF-α in mice.	TNFRSF1A IFNAR1	1.13e-05	3	68	2	33354817
Pubmed	The stability of Fbw7α in M-phase requires its phosphorylation by PKC.	PRKCA FBXW7	1.13e-05	3	68	2	28850619
Pubmed	Tissue factor binds to and inhibits interferon-α receptor 1 signaling.	LEPR IFNAR1	1.13e-05	3	68	2	38141610
Pubmed	Anthrolysin O and other gram-positive cytolysins are toll-like receptor 4 agonists.	TNFRSF1A IFNAR1	1.13e-05	3	68	2	15611291
Pubmed	Selective blockade of lymphopoiesis induced by kalanchosine dimalate: inhibition of IL-7-dependent proliferation.	TNFRSF1A IFNAR1	1.13e-05	3	68	2	18198209
Pubmed	Multiple types of programmed necrosis such as necroptosis, pyroptosis, oxytosis/ferroptosis, and parthanatos contribute simultaneously to retinal damage after ischemia-reperfusion.	TNFRSF1A IFNAR1	1.13e-05	3	68	2	36229563
Pubmed	A mosquito salivary protein promotes flavivirus transmission by activation of autophagy.	BECN1 IFNAR1	1.13e-05	3	68	2	31937766
Pubmed	Obesity intensifies sex-specific interferon signaling to selectively worsen central nervous system autoimmunity in females.	LEPR IFNAR1	1.13e-05	3	68	2	39168127
Pubmed	Cloning and mapping of members of the MYM family.	ZMYM4 ZMYM6	1.13e-05	3	68	2	10486218
Pubmed	Cheliensisin A (Chel A) induces apoptosis in human bladder cancer cells by promoting PHLPP2 protein degradation.	BECN1 PHLPP2	1.13e-05	3	68	2	27556506
Pubmed	Relative sensitivity of hepatitis B virus and other hepatotropic viruses to the antiviral effects of cytokines.	TNFRSF1A IFNAR1	1.13e-05	3	68	2	10666256
Pubmed	Evidence of a gene-environment interaction that predisposes to spontaneous preterm birth: a role for asymptomatic bacterial vaginosis and DNA variants in genes that control the inflammatory response.	FLT1 PRKCA	1.13e-05	3	68	2	20350647
Pubmed	Common polymorphism in the phosphatase PHLPP2 results in reduced regulation of Akt and protein kinase C.	PRKCA PHLPP2	1.13e-05	3	68	2	19324870
Pubmed	Oncogenic role of MIR516A in human bladder cancer was mediated by its attenuating PHLPP2 expression and BECN1-dependent autophagy.	BECN1 PHLPP2	1.13e-05	3	68	2	32116109
Pubmed	The calcium ATPase SERCA2 regulates desmoplakin dynamics and intercellular adhesive strength through modulation of PKCα signaling.	DSP PRKCA	1.13e-05	3	68	2	21156808
Pubmed	Dual inhibition of classical protein kinase C-α and protein kinase C-β isoforms protects against experimental murine diabetic nephropathy.	PRKCA LEPR	1.13e-05	3	68	2	23434935
Pubmed	VEGFR1 and PKCα signaling control melanoma vasculogenic mimicry in a VEGFR2 kinase-independent manner.	FLT1 PRKCA	1.13e-05	3	68	2	21389833
Pubmed	Transcriptional programming mediated by the histone demethylase KDM5C regulates dendritic cell population heterogeneity and function.	KDM5C IFNAR1	1.13e-05	3	68	2	39052479
Pubmed	Paneth cell TNF signaling induces gut bacterial translocation and sepsis.	TNFRSF1A IFNAR1	1.13e-05	3	68	2	39243761
Pubmed	Early developmental deletion of forebrain Ank2 causes seizure-related phenotypes by reshaping the synaptic proteome.	ANK2 NEUROD6	1.13e-05	3	68	2	37428632
Pubmed	Obesity Modulates Intestinal Intraepithelial T Cell Persistence, CD103 and CCR9 Expression, and Outcome in Dextran Sulfate Sodium-Induced Colitis.	TNFRSF1A LEPR	1.13e-05	3	68	2	31712385
Pubmed	TNF-α up-regulates protein level and cell surface expression of the leptin receptor by stimulating its export via a PKC-dependent mechanism.	PRKCA LEPR	1.13e-05	3	68	2	23070544
Pubmed	Plakophilin 2: a critical scaffold for PKC alpha that regulates intercellular junction assembly.	DSP PRKCA	1.13e-05	3	68	2	18474624
Pubmed	MPYS/STING-mediated TNF-α, not type I IFN, is essential for the mucosal adjuvant activity of (3'-5')-cyclic-di-guanosine-monophosphate in vivo.	TNFRSF1A IFNAR1	1.13e-05	3	68	2	24307739
Pubmed	Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes.	LEPR PHLPP2	1.13e-05	3	68	2	34348155
Pubmed	Monoubiquitination of filamin B regulates vascular endothelial growth factor-mediated trafficking of histone deacetylase 7.	FLNB PRKCA	2.25e-05	4	68	2	23401860
Pubmed	Restricted epithelial proliferation by lacritin via PKCalpha-dependent NFAT and mTOR pathways.	PRKCA PLCG2	2.25e-05	4	68	2	16923831
Pubmed	Protein kinase C alpha-mediated chemotaxis of neutrophils requires NF-kappa B activity but is independent of TNF alpha signaling in mouse skin in vivo.	PRKCA TNFRSF1A	2.25e-05	4	68	2	15661932
Pubmed	Interactions of FLT-1 and KDR with phospholipase C gamma: identification of the phosphotyrosine binding sites.	FLT1 PLCG2	2.25e-05	4	68	2	9398617
Pubmed	Chronic viral infections persistently alter marrow stroma and impair hematopoietic stem cell fitness.	LEPR IFNAR1	2.25e-05	4	68	2	34709350
Pubmed	Hyper-adhesion in desmosomes: its regulation in wound healing and possible relationship to cadherin crystal structure.	DSP PRKCA	2.25e-05	4	68	2	16303847
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	FLNB ANK2 CLPB DSP N4BP2L2 NCKAP5 BECN1 NEUROD6 NIPBL TARBP1 ZMYM4	3.72e-05	1285	68	11	35914814
Pubmed	Insulin action and resistance are dependent on a GSK3β-FBXW7-ERRα transcriptional axis.	LEPR FBXW7	3.75e-05	5	68	2	35440636
Pubmed	Artemis regulates cell cycle recovery from the S phase checkpoint by promoting degradation of cyclin E.	DCLRE1C FBXW7	3.75e-05	5	68	2	19423708
Pubmed	B Cell-Intrinsic STING Signaling Triggers Cell Activation, Synergizes with B Cell Receptor Signals, and Promotes Antibody Responses.	TNFRSF1A IFNAR1	3.75e-05	5	68	2	30282750
Pubmed	Essential role and therapeutic targeting of the glomerular endothelial glycocalyx in lupus nephritis.	TNFRSF1A IFNAR1	3.75e-05	5	68	2	32870819
Pubmed	TNF receptor-associated factor 6-dependent CD40 signaling primes macrophages to acquire antimicrobial activity in response to TNF-alpha.	TNFRSF1A IFNAR1	5.62e-05	6	68	2	16237096
Pubmed	Local Inflammatory Cues Regulate Differentiation and Persistence of CD8+ Tissue-Resident Memory T Cells.	IL12RB2 IFNAR1	5.62e-05	6	68	2	28380351
Pubmed	Regulation of the tumour suppressor Fbw7α by PKC-dependent phosphorylation and cancer-associated mutations.	PRKCA FBXW7	5.62e-05	6	68	2	20815813
Pubmed	MAIT cell activation augments adenovirus vector vaccine immunogenicity.	TNFRSF1A IFNAR1	5.62e-05	6	68	2	33510029
Pubmed	Platelets prevent IFN-alpha/beta-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus.	TNFRSF1A IFNAR1	5.62e-05	6	68	2	18184798
Pubmed	Endothelial TNF receptor 2 induces IRF1 transcription factor-dependent interferon-β autocrine signaling to promote monocyte recruitment.	TNFRSF1A IFNAR1	5.62e-05	6	68	2	23623383
Pubmed	Two sequential activation modules control the differentiation of protective T helper-1 (Th1) cells.	IL12RB2 IFNAR1	5.62e-05	6	68	2	33773107
Pubmed	Identification of an elaborate complex mediating postsynaptic inhibition.	IQSEC3 INSYN2A	5.62e-05	6	68	2	27609886
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	FLNB RAB34 UBN1 GNE DSP MYO9A TLN1 ELP1 PRKCA PLCG2 NIPBL	5.93e-05	1353	68	11	29467282
Pubmed	The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis.	TNFRSF1A IFNAR1	7.86e-05	7	68	2	27756058
Pubmed	Loss of KLHL6 promotes diffuse large B-cell lymphoma growth and survival by stabilizing the mRNA decay factor roquin2.	KLHL6 FBXW7	7.86e-05	7	68	2	29695787
Pubmed	The bacterial microbiota regulates normal hematopoiesis via metabolite-induced type 1 interferon signaling.	LEPR IFNAR1	7.86e-05	7	68	2	35143611
Pubmed	The transcription factor Zbtb32 controls the proliferative burst of virus-specific natural killer cells responding to infection.	IL12RB2 IFNAR1	7.86e-05	7	68	2	24747678
Pubmed	Mature B cells and mesenchymal stem cells control emergency myelopoiesis.	LEPR IFNAR1	7.86e-05	7	68	2	36717247
Pubmed	MyD88 Signaling Regulates Steady-State Migration of Intestinal CD103+ Dendritic Cells Independently of TNF-α and the Gut Microbiota.	TNFRSF1A IFNAR1	7.86e-05	7	68	2	26259586
Pubmed	A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death.	TNFRSF1A IFNAR1	7.86e-05	7	68	2	38788712
Pubmed	Activation Receptor-Dependent IFN-γ Production by NK Cells Is Controlled by Transcription, Translation, and the Proteasome.	IL12RB2 IFNAR1	7.86e-05	7	68	2	31444264
Pubmed	Modulation of T cell development and activation by novel members of the Schlafen (slfn) gene family harbouring an RNA helicase-like motif.	TNFRSF1A IFNAR1	7.86e-05	7	68	2	15351786
Pubmed	Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes.	RAB34 DCLRE1C NIPBL TARBP1	8.96e-05	119	68	4	23508102
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	FLNB IQSEC3 ANK2 DSP MYO9A TLN1 TRAPPC10 OTUD4 ELP1 PRKCA HP1BP3	9.77e-05	1431	68	11	37142655
Pubmed	GVHD prevents NK-cell-dependent leukemia and virus-specific innate immunity.	TNFRSF1A IFNAR1	1.05e-04	8	68	2	27927647
Pubmed	IFN-alpha beta-dependent, IFN-gamma secretion by bone marrow-derived macrophages controls an intracellular bacterial infection.	TNFRSF1A IFNAR1	1.05e-04	8	68	2	11714812
Pubmed	MYH9-dependent polarization of ATG9B promotes colorectal cancer metastasis by accelerating focal adhesion assembly.	FLNB TLN1	1.05e-04	8	68	2	34131310
Pubmed	The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway.	ELP1 MAP2K6	1.05e-04	8	68	2	10094049
Pubmed	OTULIN Prevents Liver Inflammation and Hepatocellular Carcinoma by Inhibiting FADD- and RIPK1 Kinase-Mediated Hepatocyte Apoptosis.	TNFRSF1A IFNAR1	1.05e-04	8	68	2	32075762
Pubmed	RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3.	TNFRSF1A IFNAR1	1.05e-04	8	68	2	24813850
Pubmed	IRGM1 links mitochondrial quality control to autoimmunity.	BECN1 IFNAR1	1.34e-04	9	68	2	33510463
Pubmed	TNF-alpha induces matrix metalloproteinase-9 expression in A549 cells: role of TNFR1/TRAF2/PKCalpha-dependent signaling pathways.	PRKCA TNFRSF1A	1.34e-04	9	68	2	20333651
Pubmed	Dendritic Cell RIPK1 Maintains Immune Homeostasis by Preventing Inflammation and Autoimmunity.	TNFRSF1A IFNAR1	1.34e-04	9	68	2	29212904
Pubmed	Lung IFNAR1hi TNFR2+ cDC2 promotes lung regulatory T cells induction and maintains lung mucosal tolerance at steady state.	TNFRSF1A IFNAR1	1.34e-04	9	68	2	31959883
Pubmed	Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits.	FLNB TLN1	1.34e-04	9	68	2	11807098
Pubmed	Corneal avascularity is due to soluble VEGF receptor-1.	FLT1 IFNAR1	1.34e-04	9	68	2	17051153
Pubmed	Bone marrow B cell apoptosis during in vivo influenza virus infection requires TNF-alpha and lymphotoxin-alpha.	TNFRSF1A IFNAR1	1.34e-04	9	68	2	12444124
Pubmed	In silico prediction of physical protein interactions and characterization of interactome orphans.	PRKCA NEIL3 PLCG2 TNFRSF1A	1.50e-04	136	68	4	25402006
Pubmed	ZBP1/DAI Drives RIPK3-Mediated Cell Death Induced by IFNs in the Absence of RIPK1.	TNFRSF1A IFNAR1	1.68e-04	10	68	2	31358656
Pubmed	OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity.	TNFRSF1A IFNAR1	1.68e-04	10	68	2	34625556
Pubmed	Interferon b drives intestinal regeneration after radiation.	TNFRSF1A IFNAR1	1.68e-04	10	68	2	34613772
Pubmed	Daily Rhythms of TNFα Expression and Food Intake Regulate Synchrony of Plasmodium Stages with the Host Circadian Cycle.	TNFRSF1A IFNAR1	1.68e-04	10	68	2	29805094
Pubmed	CD8+ T cells induce cachexia during chronic viral infection.	TNFRSF1A IFNAR1	1.68e-04	10	68	2	31110314
Pubmed	The modular nature of apoptotic signaling proteins.	ANK2 TNFRSF1A	1.68e-04	10	68	2	10442092
Pubmed	Immune effectors required for hepatitis B virus clearance.	TNFRSF1A IFNAR1	1.68e-04	10	68	2	20080755
Pubmed	MyD88-dependent IFN-gamma production by NK cells is key for control of Legionella pneumophila infection.	TNFRSF1A IFNAR1	2.05e-04	11	68	2	16670325
Pubmed	Sequence- and target-independent angiogenesis suppression by siRNA via TLR3.	FLT1 IFNAR1	2.05e-04	11	68	2	18368052
Pubmed	A spatially-organized multicellular innate immune response in lymph nodes limits systemic pathogen spread.	IL12RB2 IFNAR1	2.45e-04	12	68	2	22980983
Pubmed	Divergent Role for STAT5 in the Adaptive Responses of Natural Killer Cells.	IL12RB2 IFNAR1	2.45e-04	12	68	2	33326784
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	OTUD4 ELP1 CEP295 MORC4 SMCR8 NIPBL TARBP1	2.49e-04	638	68	7	31182584
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	KLHL6 FLNB MASTL TRAPPC10 OTUD4 N4BP2L2 CEP295 FAM135A LMBRD1	2.54e-04	1084	68	9	11544199
Pubmed	Loss of the tumor suppressor BAP1 causes myeloid transformation.	OTUD4 PRKCA	2.90e-04	13	68	2	22878500
Pubmed	TNF-α sculpts a maturation process in vivo by pruning tolerogenic dendritic cells.	TNFRSF1A IFNAR1	2.90e-04	13	68	2	35417681
Pubmed	A dual function of Bcl11b/Ctip2 in hippocampal neurogenesis.	DSP NEUROD6	2.90e-04	13	68	2	22588081
Pubmed	Proximity labeling reveals OTUD3 as a DNA-binding deubiquitinase of cGAS.	MAEA BECN1 HP1BP3	3.27e-04	68	68	3	36966392
Pubmed	Dual Requirement of Cytokine and Activation Receptor Triggering for Cytotoxic Control of Murine Cytomegalovirus by NK Cells.	IL12RB2 IFNAR1	3.38e-04	14	68	2	26720279
Pubmed	The NLRP12 inflammasome recognizes Yersinia pestis.	TNFRSF1A IFNAR1	3.38e-04	14	68	2	22840842
Pubmed	Signal 3 cytokines as modulators of primary immune responses during infections: the interplay of type I IFN and IL-12 in CD8 T cell responses.	IL12RB2 IFNAR1	3.38e-04	14	68	2	22815848
Pubmed	Associations between cytokine/cytokine receptor single nucleotide polymorphisms and humoral immunity to measles, mumps and rubella in a Somali population.	IL12RB2 TNFRSF1A	3.38e-04	14	68	2	18715339
Pubmed	LTbetaR signaling induces cytokine expression and up-regulates lymphangiogenic factors in lymph node anlagen.	FLT1 TNFRSF1A	3.38e-04	14	68	2	19380791
Interaction	NOX1 interactions	RAB34 TNFRSF1A FBXW7	9.81e-06	13	67	3	int:NOX1
Cytoband	6q13	FAM135A LMBRD1	1.55e-03	39	68	2	6q13
Cytoband	1p36.12	FAM43B HP1BP3	1.55e-03	39	68	2	1p36.12
GeneFamily	Zinc fingers MYM-type	ZMYM4 ZMYM6	7.12e-05	6	40	2	86
CoexpressionAtlas	dev gonad_e13.5_F_MeioticGermCell_Oct_top-relative-expression-ranked_1000	TDRD7 BCLAF3 DSP MYO9A CENPI ERCC6L2 MASTL OTUD4 CEP295 PLCG2 FAM135A ZMYM6 FBXW7	1.42e-06	820	67	13	gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_1000
CoexpressionAtlas	dev gonad_e11.5_F_PrimGermCell_Oct_k-means-cluster#3_top-relative-expression-ranked_500	BCLAF3 LACTB2 DSP CENPI PLCG2	3.19e-06	72	67	5	gudmap_dev gonad_e11.5_F_PrimGermCell_Oct_k3_500
CoexpressionAtlas	dev gonad_e11.5_M_PrimGermCell_Oct_k-means-cluster#1_top-relative-expression-ranked_500	BCLAF3 LACTB2 DSP PLCG2	6.33e-05	68	67	4	gudmap_dev gonad_e11.5_M_PrimGermCell_Oct_k1_500
CoexpressionAtlas	dev gonad_e11.5_F_PrimGermCell_Oct_k-means-cluster#1_top-relative-expression-ranked_200	BCLAF3 DSP PLCG2	1.03e-04	29	67	3	gudmap_dev gonad_e11.5_F_PrimGermCell_Oct_k1_200
CoexpressionAtlas	dev gonad_e13.5_F_MeioticGermCell_Oct_k-means-cluster#2_top-relative-expression-ranked_1000	BCLAF3 CENPI ERCC6L2 MASTL OTUD4 CEP295 FAM135A	1.40e-04	361	67	7	gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_k2_1000
CoexpressionAtlas	dev gonad_e13.5_F_MeioticGermCell_Oct_k-means-cluster#1_top-relative-expression-ranked_1000	TDRD7 MYO9A ZMYM6 FBXW7	1.51e-04	85	67	4	gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_k1_1000
CoexpressionAtlas	FacebaseRNAseq_e10.5_Lateral Nasal Eminence_top-relative-expression-ranked_2500_k-means-cluster#1	CCNG1 MYO9A ERCC6L2 N4BP2L2 NEIL3 NIPBL ZMYM4 HP1BP3 FBXW7 IFNAR1	1.57e-04	780	67	10	Facebase_RNAseq_e10.5_Lateral Nasal Eminence_2500_K1
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	FLNB FLT1 NCKAP5 FAM135A NIPBL LEPR	5.70e-07	200	67	6	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	moderate-Myeloid-pDC\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	FLNB TNFRSF17 MAP2K6 TARBP1 INSYN2A	7.66e-06	180	67	5	1d8df7df03a71f49d6683554d3c948ce90dda42e
ToppCell	B_cells-Plasmablasts\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	KLHL6 TPST2 PLCG2 TNFRSF17 FBXW7	9.70e-06	189	67	5	87cb7b6ba9fd57100d68e6eaeecd1ac6ab22d1c6
ToppCell	Sigmoid-(2)_B_cell\|Sigmoid / shred on region, Cell_type, and subtype	KLHL6 TPST2 TNFRSF17 FBXW7 IFNAR1	1.24e-05	199	67	5	646960845ede4c5b00cdfe73051d5d4577648bf8
ToppCell	kidney_cells-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	VPS13D TLN1 N4BP2L2 PLCG2 PTGFRN	1.24e-05	199	67	5	174f6013af6eafa577f84205a62927f2b367fda3
ToppCell	Sigmoid-B_cell\|Sigmoid / Region, Cell class and subclass	KLHL6 TPST2 TNFRSF17 FBXW7 IFNAR1	1.24e-05	199	67	5	997ee1b622b1e349d5e98026afbc4f8d283b2136
ToppCell	Sigmoid-(2)_B_cell-(20)_B_cell_IgA_Plasma\|Sigmoid / shred on region, Cell_type, and subtype	KLHL6 TPST2 TNFRSF17 FBXW7 IFNAR1	1.24e-05	199	67	5	f3c583f8521f63834d1afbf8b07940fee7712f9a
ToppCell	Sigmoid-B_cell-B_cell_IgA_Plasma\|Sigmoid / Region, Cell class and subclass	KLHL6 TPST2 TNFRSF17 FBXW7 IFNAR1	1.24e-05	199	67	5	634e0b614ab45e7520da67375b3498db5442b7ae
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Gen_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	FLNB FLT1 NCKAP5 FAM135A LEPR	1.27e-05	200	67	5	a2b9d1cd291d17abddc3ee2e242121412c864b8b
ToppCell	facs-Lung-EPCAM-3m-Endothelial-endothelial_cell_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BCLAF3 FLT1 NEIL3 ST7L	8.99e-05	156	67	4	bb64bf520cb74897a01c64924a85a1550df2b801
ToppCell	control-Epithelial-Ionocyte\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ANK2 CCBE1 NCKAP5 PLCG2	1.12e-04	165	67	4	5cfba9a46bd8ceeca74a6493057b4d38af6b06fe
ToppCell	NS-control-d_0-4-Epithelial-Ionocyte\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ANK2 CCBE1 NCKAP5 PLCG2	1.14e-04	166	67	4	6d9fb239f69ba519844f593c00d515e1aac4ff50
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_B\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	KLHL6 TPST2 CENPI FBXW7	1.17e-04	167	67	4	0130743084dbcb20e10f96715d30961122150cbf
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_B-Plasma_Cell-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	KLHL6 TPST2 CENPI FBXW7	1.17e-04	167	67	4	7bcae3797d3a0811e7f39885afdfd29ec517f11b
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_B-Plasma_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	KLHL6 TPST2 CENPI FBXW7	1.17e-04	167	67	4	c6f0209a1ad797631fdfa3efab6db6b1d3e8e315
ToppCell	control-Epithelial-Ionocyte\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ANK2 CCBE1 NCKAP5 PLCG2	1.20e-04	168	67	4	327b02f19f4a8607c033203824fdc60a1254331f
ToppCell	CF-Lymphoid-pDC\|CF / Disease state, Lineage and Cell class	FLNB MAP2K6 TARBP1 INSYN2A	1.43e-04	176	67	4	dd1e529a9e413bcaab43584afbe059e1464ffb53
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_B-plasmablast-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	FLT1 CENPI NEIL3 TNFRSF17	1.53e-04	179	67	4	021d782134126c6f7dce6b6ea50cc54bdaa39987
ToppCell	COVID-19-Epithelial-Ionocytes\|Epithelial / Condition, Lineage and Cell class	FLT1 TRAV3 ANK2 PLCG2	1.59e-04	181	67	4	4a8d4f2709c1b25f908867f1b2fae1d2d0abf1d4
ToppCell	droplet-Lung-3m-Hematologic-lymphocytic-Proliferating_T_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CENPI MASTL NEIL3 TNFRSF17	1.59e-04	181	67	4	cf13bf7a531a2d40f8d778629cf2431b684f65f3
ToppCell	droplet-Lung-3m-Hematologic-lymphocytic-Proliferating_T_cell-proliferating_T\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CENPI MASTL NEIL3 TNFRSF17	1.59e-04	181	67	4	74311aac2fe27dc02a9be3bc20e0c7ef1c239049
ToppCell	PCW_05-06-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	TDRD7 DSP RP1 WDR49	1.66e-04	183	67	4	c5b10571599dc26476170b54b53f09c23e6b3117
ToppCell	nucseq-Immune-Lymphocytic_B\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	KLHL6 PLCG2 TNFRSF17 FBXW7	1.70e-04	184	67	4	911658e7bb499c1bbc8419eec8ff88729bc39a75
ToppCell	nucseq-Immune-Lymphocytic_B-Lymphocytic_B\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	KLHL6 PLCG2 TNFRSF17 FBXW7	1.70e-04	184	67	4	942b58ae7172bb5f97e55b032db9329d161854af
ToppCell	nucseq-Immune-Lymphocytic_B-Lymphocytic_B-Plasma\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	KLHL6 PLCG2 TNFRSF17 FBXW7	1.73e-04	185	67	4	3b77bc49cd3740acc025e162a36282ac09e12198
ToppCell	Control-Endothelial-Endothelial-Artery\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FLNB FLT1 RP1 FAM135A	1.77e-04	186	67	4	2d3a975d2bf92e18e3410dd413fc9f84831d82de
ToppCell	facs-Aorta-Heart-3m-Mesenchymal-fibroblast\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCBE1 NCKAP5 PTGFRN ZMYM4	1.96e-04	191	67	4	9214655dca96d766737c9f30b624d7fe7050342e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MYO9A RP1 FAM135A LEPR	1.96e-04	191	67	4	2fa1b9e76a0ed2d2f0de74349e266cf4a5f51aad
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	IQSEC3 MYO9A CAMK1G FAM43B	1.96e-04	191	67	4	5d24022cec293bc8d9e978ae99a109e660bb8f83
ToppCell	Entopeduncular-Neuronal-Inhibitory\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	IQSEC3 MYO9A CAMK1G FAM43B	1.96e-04	191	67	4	73dae4cdea86aec62393ad7303dc7375a6b3fc86
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANK2 CCBE1 FAM43B LEPR	2.00e-04	192	67	4	b9e4585bea280ca0ae159f0c6a2bf7b88a15a6e6
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Gen_Cap\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FLNB FLT1 NCKAP5 LEPR	2.04e-04	193	67	4	e09387af84d2a0a526e54d4793e6e06c6739db53
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Gen_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FLNB FLT1 NCKAP5 LEPR	2.04e-04	193	67	4	6e1982d089a9de628e6006d23ff78a223fbd9f47
ToppCell	LPS_only-Endothelial-Endothelial-Gen_Cap\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FLNB FLT1 NCKAP5 LEPR	2.04e-04	193	67	4	af5108260783e69a7d67896c5bf64f862525926d
ToppCell	Control-Endothelial-Endothelial-Gen_Cap\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FLT1 NCKAP5 FAM135A LEPR	2.04e-04	193	67	4	e1d546165dcc2392f540162206852c4717d7306f
ToppCell	Control-NK_CD56bright\|Control / Disease condition and Cell class	TPST2 IL12RB2 FLNB PLCG2	2.04e-04	193	67	4	8b1e7a226a6057e1097c1525984127b54e823876
ToppCell	RV-10._Endothelium_II\|World / Chamber and Cluster_Paper	TPST2 FLNB FLT1 LEPR	2.04e-04	193	67	4	2531266bc57339d4e2b22a88817008e32b8c1598
ToppCell	droplet-Limb_Muscle-MUSCLE\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 UBN1 N4BP2L2 NIPBL	2.08e-04	194	67	4	e3d63874111d1e8da3977329426e4dcf68d6de87
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FLNB FLT1 NCKAP5 LEPR	2.08e-04	194	67	4	0b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-Plasma_cells-IgG_plasma_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KLHL6 TPST2 TNFRSF17 FBXW7	2.08e-04	194	67	4	f083777353e76a2d9c39f8b6cb1a689b68b81c56
ToppCell	3'-Child09-12-SmallIntestine-Hematopoietic-B_cells-Cycling_plasma_cell\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KLHL6 CENPI NEIL3 TNFRSF17	2.08e-04	194	67	4	06b8dc2e46f833707d5b68b324b4ff6c4d0dccf9
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RP1 PLCG2 WDR49 C1orf141	2.08e-04	194	67	4	4a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell	wk_15-18-Endothelial-Blood_vessel_endothelial-Venous_endo\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	TPST2 FLNB FLT1 LEPR	2.12e-04	195	67	4	cc3d6f98d310e8840ff497d7258c5ccf54e6c624
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-B-B_plasma-B_plasma_IgA\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	KLHL6 PLCG2 TNFRSF17 FBXW7	2.20e-04	197	67	4	749e0e332644543cbdf2ee38c2b301ce0a019a7f
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_secretory\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FLNB DSP NCKAP5 RP1	2.25e-04	198	67	4	af399569c718f5fd971d73a7926768c9311002a3
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-B-B_plasma\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	KLHL6 PLCG2 TNFRSF17 FBXW7	2.25e-04	198	67	4	567fcf882c8612356946240843525b786f3c8dbe
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Club\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FLNB DSP NCKAP5 RP1	2.25e-04	198	67	4	1408e02e053ad3406229bfe8189da03be6366e81
ToppCell	Sigmoid\|World / shred on region, Cell_type, and subtype	TPST2 TNFRSF17 FBXW7 IFNAR1	2.29e-04	199	67	4	83737cf4e511e660ec2d268447228cefc8a7ba9c
ToppCell	Transverse-B_cell\|Transverse / Region, Cell class and subclass	KLHL6 TPST2 TNFRSF17 IFNAR1	2.29e-04	199	67	4	91ac70fe1f351eb7ee3600a17120cd1301220041
ToppCell	Transverse-(2)_B_cell\|Transverse / shred on region, Cell_type, and subtype	KLHL6 TPST2 TNFRSF17 IFNAR1	2.29e-04	199	67	4	fcdea790d2b34efac8ce80a296db54916ab621cb
ToppCell	Tracheal-NucSeq-Immune_Lymphocytic-B-B_plasma-B_plasma_IgA\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	KLHL6 TPST2 PLCG2 TNFRSF17	2.29e-04	199	67	4	1bb02f41f3cc76a28581e38b0ca4c36b930b85b4
ToppCell	Tracheal-NucSeq-Immune_Lymphocytic-B-B_plasma\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	KLHL6 TPST2 PLCG2 TNFRSF17	2.29e-04	199	67	4	2f60682f1b82918a65e8851e99c9e3398845b62f
ToppCell	Transverse-(2)_B_cell-(20)_B_cell_IgA_Plasma\|Transverse / shred on region, Cell_type, and subtype	TPST2 TNFRSF17 FBXW7 IFNAR1	2.29e-04	199	67	4	8caaa08b046f766af298d03961ccac6e4569e2a6
ToppCell	Caecum-(2)_B_cell-(20)_B_cell_IgA_Plasma\|Caecum / shred on region, Cell_type, and subtype	KLHL6 TPST2 TNFRSF17 FBXW7	2.29e-04	199	67	4	76b3c2ee5da8ddc214e5919b5804dfedcbb60d30
ToppCell	Tracheal-NucSeq-Immune_Lymphocytic-B\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	KLHL6 TPST2 PLCG2 TNFRSF17	2.29e-04	199	67	4	58242d78517c05fa367a7c6edac57ef79107453c
ToppCell	Caecum-B_cell-B_cell_IgA_Plasma\|Caecum / Region, Cell class and subclass	KLHL6 TPST2 TNFRSF17 FBXW7	2.29e-04	199	67	4	49c19601566205f41f04bfb5714f865398482d39
ToppCell	Transverse-B_cell-B_cell_IgA_Plasma\|Transverse / Region, Cell class and subclass	TPST2 TNFRSF17 FBXW7 IFNAR1	2.29e-04	199	67	4	ea65cadaf464ff4c1040fceb5f3724706f8447c1
ToppCell	Sigmoid\|World / Region, Cell class and subclass	TPST2 TNFRSF17 FBXW7 IFNAR1	2.29e-04	199	67	4	5b05ba8d24b33e88800777cf2cb0d5a6c8eea1d7
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_\|World / Primary Cells by Cluster	ANK2 CCBE1 NEUROD6 FBXW7	2.29e-04	199	67	4	058373b4ac3cec2108cb24265628ff0a50646e33
ToppCell	Tracheal-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_arterial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	FLNB FLT1 PLCG2 LEPR	2.33e-04	200	67	4	5ec31c1be6bcc4124e1489d136570f3de33cc2e9
ToppCell	LPS_only-Endothelial-Endothelial-Gen_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	FLNB FLT1 NCKAP5 LEPR	2.33e-04	200	67	4	eb94a5111ef0e903ee5be9f7efe571b4e6d5fce1
ToppCell	Control_saline-Endothelial-Endothelial-Gen_Cap\|Control_saline / Treatment groups by lineage, cell group, cell type	FLNB FLT1 NCKAP5 LEPR	2.33e-04	200	67	4	3b97920e1e6e2f09ddba2a861baa9c00c2970f4c
ToppCell	Control_saline-Endothelial-Endothelial-Artery\|Control_saline / Treatment groups by lineage, cell group, cell type	FLNB FLT1 RP1 FAM135A	2.33e-04	200	67	4	65b71f1e8da5c3750fcd0a2e66d9ef3125a3f78a
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Artery\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	FLNB FLT1 RP1 FAM135A	2.33e-04	200	67	4	ac9ead34afa14067171833f5c277eaf06db7b02e
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Activated_Gen_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	FLNB FLT1 NCKAP5 LEPR	2.33e-04	200	67	4	f15fffefe372005c33e31845982e2d2714ac26af
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Upper_Layer\|World / Primary Cells by Cluster	ANK2 CCBE1 NEUROD6 FBXW7	2.33e-04	200	67	4	db10f76938af553d1a2275bb02ef75dff3c3135b
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Upper_Layer-21\|World / Primary Cells by Cluster	ANK2 CCBE1 NEUROD6 FBXW7	2.33e-04	200	67	4	30a3e4aee12ec1b5acdce90f86c9733c27a7f6fc
ToppCell	Tracheal-NucSeq-Immune_Lymphocytic-B-B_plasma-B_plasma_IgG\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	KLHL6 TPST2 PLCG2 TNFRSF17	2.33e-04	200	67	4	e1b3fc516887510b18cf688ada0e00b5f5eff684
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	FLNB FLT1 NCKAP5 LEPR	2.33e-04	200	67	4	b2d4e6f3e8e4da62e6b02758ab2ed8f505269f9a
ToppCell	COVID-19\|World / Disease, condition lineage and cell class	TLN1 TRAPPC10 PLCG2 NIPBL	2.33e-04	200	67	4	7dec470c379cd89f05a0f37c8628b21f136e52f0
ToppCell	(54)_pDC\|World / shred on Cell_type and subtype	FLNB IQSEC3 WDR49 INSYN2A	2.47e-04	203	67	4	b8ba3e51770ff7b45cd02472f3e63aa4d5816f6f
Drug	Harmine hydrochloride [343-27-1]; Down 200; 16uM; MCF7; HT_HG-U133A	FLNB MTMR4 CENPI N4BP2L2 PLCG2 NIPBL HP1BP3	1.12e-06	183	67	7	2750_DN
Disease	breast carcinoma, hormone replacement therapy	FLT1 PLCG2	1.48e-05	3	66	2	EFO_0000305, EFO_0003961
Disease	dilated cardiomyopathy (is_implicated_in)	DSP PRKCA LEPR	1.24e-04	43	66	3	DOID:12930 (is_implicated_in)
Disease	response to carboplatin, response to antineoplastic agent	FLNB PLCG2	2.19e-04	10	66	2	GO_0097327, GO_0097328
Disease	breast cancer (biomarker_via_orthology)	CCNG1 FLT1	3.78e-04	13	66	2	DOID:1612 (biomarker_via_orthology)
Disease	ovarian carcinoma (is_implicated_in)	CCNG1 MAP2K6	5.08e-04	15	66	2	DOID:4001 (is_implicated_in)
Disease	schizophrenia (biomarker_via_orthology)	KDM5C BECN1	5.08e-04	15	66	2	DOID:5419 (biomarker_via_orthology)
Disease	hypertrophic cardiomyopathy (is_marker_for)	DSP BECN1	6.56e-04	17	66	2	DOID:11984 (is_marker_for)
Disease	ischemia (biomarker_via_orthology)	PRKCA BECN1	7.37e-04	18	66	2	DOID:326 (biomarker_via_orthology)
Disease	chronic obstructive pulmonary disease (is_marker_for)	FLT1 TNFRSF1A LEPR	1.36e-03	97	66	3	DOID:3083 (is_marker_for)
Disease	Diabetes Mellitus, Non-Insulin-Dependent	MAEA TNFRSF1A LEPR BHMT	1.53e-03	221	66	4	C0011860
Disease	Depressive Symptoms	NCKAP5 IFNAR1	1.55e-03	26	66	2	C0086132
Disease	prostate carcinoma in situ (is_marker_for)	FLT1 MAP2K6	1.79e-03	28	66	2	DOID:8634 (is_marker_for)
Disease	ovarian carcinoma (is_marker_for)	CCNG1 PRKCA	1.79e-03	28	66	2	DOID:4001 (is_marker_for)
Disease	Streptozotocin Diabetes	PRKCA TNFRSF1A LEPR	1.85e-03	108	66	3	C0038433
Disease	Diabetes Mellitus, Experimental	PRKCA TNFRSF1A LEPR	1.85e-03	108	66	3	C0011853
Disease	Alloxan Diabetes	PRKCA TNFRSF1A LEPR	1.85e-03	108	66	3	C0002152
Disease	muscular atrophy (biomarker_via_orthology)	CCNG1 MTMR4	1.92e-03	29	66	2	DOID:767 (biomarker_via_orthology)
Disease	mean platelet volume	BCLAF3 UBN1 CCBE1 N4BP2L2 PLCG2 ST7L WDR49 LEPR	1.93e-03	1020	66	8	EFO_0004584
Disease	proteinuria (implicated_via_orthology)	NCKAP5 LEPR	2.06e-03	30	66	2	DOID:576 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
PSYLSCKSETEVKKV	BHMT	126	Q93088
TSSALPVKCYSKPFK	C1orf141	361	Q5JVX7
DQKDTTPYSSKLLKS	MASTL	256	Q96GX5
PKTCSTTALKKYVLE	HP1BP3	356	Q5SSJ5
YATVSSPSKSKKLEC	OTUD4	541	Q01804
SDDSNLYLTASKKKP	RAB34	241	Q9BZG1
KSTGVQTSPDLKKCY	INSYN2A	101	Q6ZSG2
SLDSKTKCPVKTRSY	ANK2	3396	Q01484
SKCLTEYSSNKCSKP	CCNG1	246	P51959
LATDKTQCYDPSTNK	KLHL6	481	Q8WZ60
AIKTPQCYKEDGSSK	MAEA	296	Q7L5Y9
KPKTAQYSSPELKSC	NEIL3	466	Q8TAT5
TSKCTQIKTALKYTL	LMBRD1	131	Q9NUN5
KICNKSSSAYTPLKC	NCR3LG1	286	Q68D85
AKCKAKSLSPGLAYT	FAM43B	16	Q6ZT52
NSTCAKKYPIAEEKT	IL12RB2	671	Q99665
SLTDKSKELPLYCSG	BECN1	341	Q14457
ESPCNVKYSSKSKFD	FAM135A	1161	Q9P2D6
CYSAIPKASSDASKV	FLNB	2501	O75369
KLSPETTYCLKVKAA	IFNAR1	191	P17181
KSINNDTTYCIKKLP	LACTB2	91	Q53H82
DSSYKPVKKACTQLV	NIPBL	1961	Q6KC79
KCFSSKNSPLKDSFS	LEPR	1011	P48357
YLKQSLSFSTCGKSK	ELP1	331	O95163
SDLVVYCKPTSKTKD	PLCG2	931	P16885
KLCPKKKSSSTYTFC	IQSEC3	906	Q9UPP2
PFKSHKSCSPSYKLL	MTMR4	691	Q9NYA4
EITTYKKKLSTNQPC	ETAA1	786	Q9NY74
SSYCSEPTLLKKANK	CAMK1G	431	Q96NX5
PFKPSKKDSIACTYS	BCLAF3	341	A2AJT9
KPLCRSSQSTEPKYK	DCLRE1C	356	Q96SD1
AGCPSYDKLLSAKNK	GNE	181	Q9Y223
DTSSYAKILTCPKTK	DSP	2766	P15924
KIATTKYPCLKSSGE	CCBE1	51	Q6UXH8
FSLGKKPCKVSEYTS	FBXW7	181	Q969H0
CYSKSPSNKDAALLE	CLPB	126	Q9H078
PANIAVCSSKTYKEK	ERCC6L2	1166	Q5T890
CKYVSLATLKKAVST	H1-9P	131	P60008
PVLNSSSYTKECGKK	CENPI	311	Q92674
AEAKPKSTCELYSSQ	CEP295	1661	Q9C0D2
SYSESSPDLKKCIKS	RP1	1571	P56715
TSQCLKKNSKERPTY	MAP2K6	291	P52564
CKVSSKNIKSPRYSV	PTGFRN	571	Q9P2B2
LTQAKCKASYPLKIT	PRSS3P2	166	Q8NHM4
SYPKSLSKEAVSVCK	PRKCA	556	P17252
IKSSSLKEYPPCKTA	NCKAP5	441	O14513
KPLDSSVLQFSSKYK	MORC4	551	Q8TE76
EKSKAYKLNPKFCSL	TDRD7	556	Q8NHU6
AYTPKLIKAKSTKCF	SMCR8	301	Q8TEV9
CNKDPFTLKSSVYLS	TPST2	156	O60704
PLAAAKKLCTLAQSY	PHLPP2	1006	Q6ZVD8
LQKSPSTSCLYGKKL	PHLPP2	1226	Q6ZVD8
ALQCSPSDAYTKKEL	TLN1	1936	Q9Y490
EYCLNSSKNKITKAP	WDR49	451	Q8IV35
LPKLTNNCSDESLYK	TEX43	11	Q6ZNM6
PKSAAICYTAALLKT	ST7L	361	Q8TDW4
KKPSALVSDSALYFC	TRAV3	96	A0A0B4J244
CSQSCLSSYELKKKP	ZMYM6	166	O95789
QEKKPESSGYKELSC	UBN1	751	Q9NPG3
TAKSLDLTQYCFPEK	TARBP1	1546	Q13395
TAQSPYKKLKEALSS	TRAPPC10	436	P48553
SCKYLAVPTSKKKET	FLT1	106	P17948
LVTTKTNDYCKSLPA	TNFRSF17	156	Q02223
SKLYSIVCGKSTPEK	TNFRSF1A	241	P19438
SCITAYKQKSAKITP	ZMYM4	516	Q5VZL5
KPSSLAQKEYLSQSC	VPS13D	1696	Q5THJ4
SKTFLKKNSCYTLLE	KDM5C	1086	P41229
PRCKKLKSTTESYVF	N4BP2L2	21	Q92802
AKCSKKYDPELSSRQ	MYO9A	2046	B2RTY4
VPCYSKTQKLSKIET	NEUROD6	121	Q96NK8