Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF823 ZNF567 ZNF136 ZNF140 ZNF586 ZNF670 ZNF175 ZNF177 ZNF780B ZFP57 ZNF571 ZFP14 ZNF101 ZNF699 ZNF442 ZNF404 ZNF331 ZNF563 ZNF430 ZNF776 ZNF878 ZNF100 ZNF780A ZNF587 ZNF69 ZNF81 ZNF30 ZNF700 ZNF844 ZNF418 ZNF417 ZNF709 ZNF791 ZNF669	1.08e-13	1459	108	34	GO:0000977
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF823 ZNF136 ZNF140 ZNF586 ZNF670 ZNF175 ZNF177 ZNF780B ZFP57 ZNF571 ZFP14 ZNF101 ZNF699 ZNF442 ZNF404 ZNF331 ZNF563 ZNF430 ZNF776 ZNF878 ZNF100 ZNF780A ZNF587 ZNF69 ZNF81 ZNF30 ZNF700 ZNF844 ZNF418 ZNF417 ZNF709 ZNF791 ZNF669	2.56e-13	1412	108	33	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF567 ZNF136 ZNF140 ZNF586 ZNF670 ZNF175 ZNF780B ZNF571 ZFP14 ZNF101 ZNF699 ZNF331 ZNF430 ZNF776 ZNF100 ZNF780A ZNF587 ZNF81 ZNF30 ZNF844 ZNF418 ZNF417 ZNF709	1.68e-07	1244	108	23	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF567 ZNF136 ZNF140 ZNF586 ZNF670 ZNF175 ZNF780B ZNF571 ZFP14 ZNF101 ZNF699 ZNF331 ZNF430 ZNF776 ZNF100 ZNF780A ZNF587 ZNF81 ZNF30 ZNF844 ZNF418 ZNF417 ZNF709	2.46e-07	1271	108	23	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity	ZNF140 ZNF670 ZNF175 ZNF101 ZNF699 ZNF844 ZNF418 ZNF709	3.96e-04	326	108	8	GO:0001217
GeneOntologyMolecularFunction	polysaccharide binding	CLEC18A CLEC18B CLEC18C	6.19e-04	31	108	3	GO:0030247
MousePheno	hypochlorhydria	TRIM73 TRIM50 TRIM74	3.63e-06	7	67	3	MP:0008001
Domain	KRAB	ZNF823 ZNF567 ZNF136 ZNF140 ZNF586 ZNF670 ZNF175 ZNF177 ZNF780B ZFP57 ZNF571 ZFP14 ZNF101 ZNF699 ZNF442 ZNF404 ZNF331 ZNF563 ZNF430 ZNF776 ZNF878 ZNF100 ZNF780A ZNF587 ZNF69 ZNF81 ZNF30 ZNF700 ZNF844 ZNF418 ZNF417 ZNF738 ZNF709 ZNF791 ZNF669	1.19e-33	358	108	35	PS50805
Domain	KRAB	ZNF823 ZNF567 ZNF136 ZNF140 ZNF586 ZNF670 ZNF175 ZNF177 ZNF780B ZFP57 ZNF571 ZFP14 ZNF101 ZNF699 ZNF442 ZNF404 ZNF331 ZNF563 ZNF430 ZNF776 ZNF878 ZNF100 ZNF780A ZNF587 ZNF69 ZNF81 ZNF30 ZNF700 ZNF844 ZNF418 ZNF417 ZNF738 ZNF709 ZNF791 ZNF669	1.19e-33	358	108	35	PF01352
Domain	KRAB	ZNF823 ZNF567 ZNF136 ZNF140 ZNF586 ZNF670 ZNF175 ZNF177 ZNF780B ZFP57 ZNF571 ZFP14 ZNF101 ZNF699 ZNF442 ZNF404 ZNF331 ZNF563 ZNF430 ZNF776 ZNF878 ZNF100 ZNF780A ZNF587 ZNF69 ZNF81 ZNF30 ZNF700 ZNF844 ZNF418 ZNF417 ZNF738 ZNF709 ZNF791 ZNF669	3.47e-33	369	108	35	SM00349
Domain	KRAB	ZNF823 ZNF567 ZNF136 ZNF140 ZNF586 ZNF670 ZNF175 ZNF177 ZNF780B ZFP57 ZNF571 ZFP14 ZNF101 ZNF699 ZNF442 ZNF404 ZNF331 ZNF563 ZNF430 ZNF776 ZNF878 ZNF100 ZNF780A ZNF587 ZNF69 ZNF81 ZNF30 ZNF700 ZNF844 ZNF418 ZNF417 ZNF738 ZNF709 ZNF791 ZNF669	3.82e-33	370	108	35	IPR001909
Domain	zf-C2H2_6	ZNF823 ZNF567 ZNF136 ZNF140 ZNF586 ZNF670 ZNF780B ZNF571 ZFP14 ZNF699 ZNF442 ZNF404 ZNF331 ZNF878 ZNF100 ZNF780A ZNF587 ZNF69 ZNF30 ZNF700 ZNF844 ZNF418 ZNF417 ZNF709 ZNF791 ZNF669	5.21e-23	314	108	26	PF13912
Domain	zf-C2H2	ZNF823 ZNF567 ZNF136 ZNF140 ZNF586 ZNF670 ZNF175 ZNF177 ZNF780B ZFP57 ZNF571 ZFP14 ZNF101 ZNF699 ZNF442 ZNF404 ZNF331 ZNF563 ZNF430 ZNF776 ZNF878 ZNF100 ZNF780A ZNF587 ZNF69 ZNF81 ZNF30 ZNF700 ZNF844 ZNF418 ZNF417 ZNF709 ZNF791 ZNF669	1.06e-22	693	108	34	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF823 ZNF567 ZNF136 ZNF140 ZNF586 ZNF670 ZNF175 ZNF177 ZNF780B ZFP57 ZNF571 ZFP14 ZNF101 ZNF699 ZNF442 ZNF404 ZNF331 ZNF563 ZNF430 ZNF776 ZNF878 ZNF100 ZNF780A ZNF587 ZNF69 ZNF81 ZNF30 ZNF700 ZNF844 ZNF418 ZNF417 ZNF709 ZNF791 ZNF669	1.11e-22	694	108	34	IPR013087
Domain	-	ZNF823 ZNF567 ZNF136 ZNF140 ZNF586 ZNF670 ZNF175 ZNF780B ZFP57 ZNF571 ZFP14 ZNF101 ZNF699 ZNF442 ZNF404 ZNF331 ZNF563 ZNF430 ZNF776 ZNF878 ZNF100 ZNF780A ZNF587 ZNF69 ZNF81 ZNF30 ZNF700 ZNF844 ZNF418 ZNF417 ZNF709 ZNF791 ZNF669	6.94e-22	679	108	33	3.30.160.60
Domain	ZINC_FINGER_C2H2_2	ZNF823 ZNF567 ZNF136 ZNF140 ZNF586 ZNF670 ZNF175 ZNF177 ZNF780B ZFP57 ZNF571 ZFP14 ZNF101 ZNF699 ZNF442 ZNF404 ZNF331 ZNF563 ZNF430 ZNF776 ZNF878 ZNF100 ZNF780A ZNF587 ZNF69 ZNF81 ZNF30 ZNF700 ZNF844 ZNF418 ZNF417 ZNF709 ZNF791 ZNF669	3.73e-21	775	108	34	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF823 ZNF567 ZNF136 ZNF140 ZNF586 ZNF670 ZNF175 ZNF177 ZNF780B ZFP57 ZNF571 ZFP14 ZNF101 ZNF699 ZNF442 ZNF404 ZNF331 ZNF563 ZNF430 ZNF776 ZNF878 ZNF100 ZNF780A ZNF587 ZNF69 ZNF81 ZNF30 ZNF700 ZNF844 ZNF418 ZNF417 ZNF709 ZNF791 ZNF669	4.05e-21	777	108	34	PS00028
Domain	Znf_C2H2-like	ZNF823 ZNF567 ZNF136 ZNF140 ZNF586 ZNF670 ZNF175 ZNF177 ZNF780B ZFP57 ZNF571 ZFP14 ZNF101 ZNF699 ZNF442 ZNF404 ZNF331 ZNF563 ZNF430 ZNF776 ZNF878 ZNF100 ZNF780A ZNF587 ZNF69 ZNF81 ZNF30 ZNF700 ZNF844 ZNF418 ZNF417 ZNF709 ZNF791 ZNF669	8.68e-21	796	108	34	IPR015880
Domain	Znf_C2H2	ZNF823 ZNF567 ZNF136 ZNF140 ZNF586 ZNF670 ZNF175 ZNF177 ZNF780B ZFP57 ZNF571 ZFP14 ZNF101 ZNF699 ZNF442 ZNF404 ZNF331 ZNF563 ZNF430 ZNF776 ZNF878 ZNF100 ZNF780A ZNF587 ZNF69 ZNF81 ZNF30 ZNF700 ZNF844 ZNF418 ZNF417 ZNF709 ZNF791 ZNF669	1.24e-20	805	108	34	IPR007087
Domain	ZnF_C2H2	ZNF823 ZNF567 ZNF136 ZNF140 ZNF586 ZNF670 ZNF175 ZNF177 ZNF780B ZFP57 ZNF571 ZFP14 ZNF101 ZNF699 ZNF442 ZNF404 ZNF331 ZNF563 ZNF430 ZNF776 ZNF878 ZNF100 ZNF780A ZNF587 ZNF69 ZNF81 ZNF30 ZNF700 ZNF844 ZNF418 ZNF417 ZNF709 ZNF791 ZNF669	1.39e-20	808	108	34	SM00355
Domain	-	CLEC18A CLEC18B CLEC18C	8.13e-05	15	108	3	3.40.33.10
Domain	CAP	CLEC18A CLEC18B CLEC18C	8.13e-05	15	108	3	PF00188
Domain	CAP_domain	CLEC18A CLEC18B CLEC18C	8.13e-05	15	108	3	IPR014044
Domain	SCP	CLEC18A CLEC18B CLEC18C	8.13e-05	15	108	3	SM00198
Domain	Allrgn_V5/Tpx1	CLEC18A CLEC18B CLEC18C	8.13e-05	15	108	3	IPR001283
Domain	EGF	CLEC18A RELN CLEC18B CLEC18C F9 LRP8 BRINP2	4.33e-04	235	108	7	SM00181
Domain	EF-hand_Ca_insen	SPTA1 SPTAN1	4.89e-04	6	108	2	IPR014837
Domain	EFhand_Ca_insen	SPTA1 SPTAN1	4.89e-04	6	108	2	PF08726
Domain	Mob1_phocein	MOB1B MOB1A	6.83e-04	7	108	2	PF03637
Domain	MOB_kinase_act_fam	MOB1B MOB1A	6.83e-04	7	108	2	IPR005301
Domain	-	MOB1B MOB1A	6.83e-04	7	108	2	1.20.140.30
Domain	Mob1_phocein	MOB1B MOB1A	6.83e-04	7	108	2	SM01388
Domain	Znf-RING_LisH	TRIM73 TRIM50 TRIM74	9.88e-04	34	108	3	IPR027370
Domain	zf-RING_UBOX	TRIM73 TRIM50 TRIM74	9.88e-04	34	108	3	PF13445
Domain	C-type_lectin_CS	CLEC18A CLEC18B CLEC18C	1.96e-03	43	108	3	IPR018378
Domain	EGF_3	CLEC18A RELN CLEC18B CLEC18C F9 LRP8	2.45e-03	235	108	6	PS50026
Domain	EGF-like_dom	CLEC18A RELN CLEC18B CLEC18C F9 LRP8	3.26e-03	249	108	6	IPR000742
Domain	Spectrin_alpha_SH3	SPTA1 SPTAN1	3.31e-03	15	108	2	IPR013315
Domain	CTDL_fold	COL4A6 CLEC18A CLEC18B CLEC18C	3.46e-03	107	108	4	IPR016187
Domain	EGF_1	CLEC18A RELN CLEC18B CLEC18C F9 LRP8	3.67e-03	255	108	6	PS00022
Domain	EGF-like_CS	CLEC18A RELN CLEC18B CLEC18C F9 LRP8	4.10e-03	261	108	6	IPR013032
Domain	EGF_2	CLEC18A RELN CLEC18B CLEC18C F9 LRP8	4.42e-03	265	108	6	PS01186
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	ZNF567 ZNF136 ZNF140 ZNF586 ZNF670 ZNF175 ZNF571 ZFP14 ZNF101 ZNF699 ZNF442 ZNF331 ZNF563 ZNF430 ZNF776 ZNF100 L3MBTL1 ATRIP ZNF587 USP7 SNAPC1 ZNF30 ZNF700 ZNF418 ZNF417 ZNF738 ZNF709 ZNF791 ZNF669	8.98e-10	1387	85	29	M734
Pathway	REACTOME_GENERIC_TRANSCRIPTION_PATHWAY	ZNF823 ZNF136 ZNF670 ZNF780B ZFP14 ZNF101 ZNF699 ZNF442 ZNF563 L3MBTL1 ATRIP ZNF780A USP7 ZNF844 ZNF418 ZNF709	1.18e-05	768	85	16	MM14851
Pathway	REACTOME_GENE_EXPRESSION_TRANSCRIPTION	ZNF823 ZNF136 ZNF670 TAF1B ZNF780B ZFP14 ZNF101 ZNF699 ZNF442 ZNF563 L3MBTL1 ATRIP ZNF780A USP7 SNAPC1 ZNF844 ZNF418 ZNF709	3.04e-05	1022	85	18	MM15436
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF567 ZNF136 ZNF140 ZNF670 ZNF101 ZNF699 ZNF563 ZNF430 ZNF776 ZNF878 ZNF100 ZNF780A ZNF587 ZNF417 ZNF738 ZNF791 ZNF669	1.28e-20	181	108	17	37372979
Pubmed	Allele-specific binding of ZFP57 in the epigenetic regulation of imprinted and non-imprinted monoallelic expression.	TRIM73 ZFP57 TRIM50 TRIM74	3.06e-09	7	108	4	26025256
Pubmed	Human CLEC18 Gene Cluster Contains C-type Lectins with Differential Glycan-binding Specificity.	CLEC18A CLEC18B CLEC18C	2.91e-08	3	108	3	26170455
Pubmed	Gene structure variation in segmental duplication block C of human chromosome 7q 11.23 during primate evolution.	TRIM73 TRIM50 TRIM74	2.91e-08	3	108	3	26196062
Pubmed	The C-type lectin-like domain superfamily.	CLEC18A CLEC18B CLEC18C	2.91e-08	3	108	3	16336259
Pubmed	Endosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection.	CLEC18A CLEC18B CLEC18C	2.91e-08	3	108	3	33603190
Pubmed	TRIM50 protein regulates vesicular trafficking for acid secretion in gastric parietal cells.	TRIM73 TRIM50 TRIM74	2.91e-08	3	108	3	22872646
Pubmed	The mannose receptor mediates uptake of soluble but not of cell-associated antigen for cross-presentation.	CLEC18A CLEC18B CLEC18C	1.16e-07	4	108	3	16709836
Pubmed	Williams-Beuren syndrome TRIM50 encodes an E3 ubiquitin ligase.	TRIM73 TRIM50 TRIM74	2.90e-07	5	108	3	18398435
Pubmed	Induced chromosome deletions cause hypersociability and other features of Williams-Beuren syndrome in mice.	TRIM73 TRIM50 TRIM74	2.90e-07	5	108	3	20049703
Pubmed	TRIM50 regulates Beclin 1 proautophagic activity.	TRIM73 TRIM50 TRIM74	5.78e-07	6	108	3	29604308
Pubmed	TRIM50 promotes NLRP3 inflammasome activation by directly inducing NLRP3 oligomerization.	TRIM73 TRIM50 TRIM74	5.78e-07	6	108	3	36178239
Pubmed	Decreased generation of C-terminal fragments of ApoER2 and increased reelin expression in Alzheimer's disease.	RELN LRP8	9.55e-06	2	108	2	29442527
Pubmed	Depletion of MOB1A/B causes intestinal epithelial degeneration by suppressing Wnt activity and activating BMP/TGF-β signaling.	MOB1B MOB1A	9.55e-06	2	108	2	30349003
Pubmed	Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice.	MOB1B MOB1A	9.55e-06	2	108	2	23143302
Pubmed	Structural basis for ligand capture and release by the endocytic receptor ApoER2.	RELN LRP8	9.55e-06	2	108	2	28446613
Pubmed	Dentate granule cells in reeler mutants and VLDLR and ApoER2 knockout mice.	RELN LRP8	9.55e-06	2	108	2	12093079
Pubmed	LRP8-Reelin-Regulated Neuronal Enhancer Signature Underlying Learning and Memory Formation.	RELN LRP8	9.55e-06	2	108	2	25892301
Pubmed	A secreted soluble form of ApoE receptor 2 acts as a dominant-negative receptor and inhibits Reelin signaling.	RELN LRP8	9.55e-06	2	108	2	12426372
Pubmed	Human Mob1 proteins are required for cytokinesis by controlling microtubule stability.	MOB1B MOB1A	9.55e-06	2	108	2	22454515
Pubmed	αII-spectrin regulates invadosome stability and extracellular matrix degradation.	SPTA1 SPTAN1	9.55e-06	2	108	2	25830635
Pubmed	Gemin proteins are required for efficient assembly of Sm-class ribonucleoproteins.	GEMIN4 DDX20	9.55e-06	2	108	2	16301532
Pubmed	Reelin supplementation enhances cognitive ability, synaptic plasticity, and dendritic spine density.	RELN LRP8	9.55e-06	2	108	2	21852430
Pubmed	The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome.	TRIM73 TRIM50 TRIM74	1.58e-05	16	108	3	22792322
Pubmed	Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.	ZNF670 ZNF175 ZNF101 ZNF844	1.67e-05	49	108	4	9630514
Pubmed	Reelin together with ApoER2 regulates interneuron migration in the olfactory bulb.	RELN LRP8	2.86e-05	3	108	2	23209795
Pubmed	EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1.	MOB1B MOB1A	2.86e-05	3	108	2	34725466
Pubmed	Reelin, very-low-density lipoprotein receptor, and apolipoprotein E receptor 2 control somatic NMDA receptor composition during hippocampal maturation in vitro.	RELN LRP8	2.86e-05	3	108	2	15987942
Pubmed	Functional importance of covalent homodimer of reelin protein linked via its central region.	RELN LRP8	2.86e-05	3	108	2	21844191
Pubmed	Reelin controls neuronal positioning by promoting cell-matrix adhesion via inside-out activation of integrin α5β1.	RELN LRP8	2.86e-05	3	108	2	23083738
Pubmed	The human tumour suppressor LATS1 is activated by human MOB1 at the membrane.	MOB1B MOB1A	2.86e-05	3	108	2	16674920
Pubmed	Functional consequences of hippocampal neuronal ectopia in the apolipoprotein E receptor-2 knockout mouse.	RELN LRP8	2.86e-05	3	108	2	18778775
Pubmed	Contributions of VLDLR and LRP8 in the establishment of retinogeniculate projections.	RELN LRP8	2.86e-05	3	108	2	23758727
Pubmed	OCRL1 Deficiency Affects the Intracellular Traffic of ApoER2 and Impairs Reelin-Induced Responses.	RELN LRP8	2.86e-05	3	108	2	39062513
Pubmed	ApoER2 function in the establishment and maintenance of retinal synaptic connectivity.	RELN LRP8	2.86e-05	3	108	2	21976526
Pubmed	Reelin and its receptors, VLDLR and ApoER2, in melanocytic nevi.	RELN LRP8	2.86e-05	3	108	2	28255385
Pubmed	Beta-amyloid impairs reelin signaling.	RELN LRP8	2.86e-05	3	108	2	23951306
Pubmed	Curcumin suppresses NTHi-induced CXCL5 expression via inhibition of positive IKKβ pathway and up-regulation of negative MKP-1 pathway.	DUSP1 IKBKB	2.86e-05	3	108	2	27538525
Pubmed	Ankyrin-independent membrane protein-binding sites for brain and erythrocyte spectrin.	SPTA1 SPTAN1	2.86e-05	3	108	2	2971657
Pubmed	The cytoplasmic adaptor protein X11alpha and extracellular matrix protein Reelin regulate ApoE receptor 2 trafficking and cell movement.	RELN LRP8	2.86e-05	3	108	2	19720620
Pubmed	miRNP:mRNA association in polyribosomes in a human neuronal cell line.	GEMIN4 DDX20	2.86e-05	3	108	2	14970384
Pubmed	C-Terminal Region Truncation of RELN Disrupts an Interaction with VLDLR, Causing Abnormal Development of the Cerebral Cortex and Hippocampus.	RELN LRP8	2.86e-05	3	108	2	28123028
Pubmed	ApoER2 processing by presenilin-1 modulates reelin expression.	RELN LRP8	2.86e-05	3	108	2	24344333
Pubmed	Abnormal positioning of granule cells alters afferent fiber distribution in the mouse fascia dentata: morphologic evidence from reeler, apolipoprotein E receptor 2-, and very low density lipoprotein receptor knockout mice.	RELN LRP8	2.86e-05	3	108	2	11920707
Pubmed	Differential functions of ApoER2 and very low density lipoprotein receptor in Reelin signaling depend on differential sorting of the receptors.	RELN LRP8	2.86e-05	3	108	2	19948739
Pubmed	Binding of purified Reelin to ApoER2 and VLDLR mediates tyrosine phosphorylation of Disabled-1.	RELN LRP8	2.86e-05	3	108	2	12670700
Pubmed	ApoER2 and Reelin are expressed in regenerating peripheral nerve and regulate Schwann cell migration by activating the Rac1 GEF protein, Tiam1.	RELN LRP8	2.86e-05	3	108	2	26386179
Pubmed	[Expression of MMP-2, MMP-9 and collagen type IV and their relationship in colorectal carcinomas].	COL4A6 MMP2	2.86e-05	3	108	2	18782525
Pubmed	Apolipoprotein E receptors are required for reelin-induced proteasomal degradation of the neuronal adaptor protein Disabled-1.	RELN LRP8	2.86e-05	3	108	2	15175346
Pubmed	DAB1 and Reelin effects on amyloid precursor protein and ApoE receptor 2 trafficking and processing.	RELN LRP8	2.86e-05	3	108	2	16951405
Pubmed	ETAA1 acts at stalled replication forks to maintain genome integrity.	HELB ATRIP ETAA1	3.72e-05	21	108	3	27723720
Pubmed	PTEN-GSK3β-MOB1 axis controls neurite outgrowth in vitro and in vivo.	MOB1B MOB1A	5.71e-05	4	108	2	30069702
Pubmed	Functional dissection of Reelin signaling by site-directed disruption of Disabled-1 adaptor binding to apolipoprotein E receptor 2: distinct roles in development and synaptic plasticity.	RELN LRP8	5.71e-05	4	108	2	16481437
Pubmed	Disabled1 regulates the intracellular trafficking of reelin receptors.	RELN LRP8	5.71e-05	4	108	2	15718228
Pubmed	Identification of a candidate human spectrin Src homology 3 domain-binding protein suggests a general mechanism of association of tyrosine kinases with the spectrin-based membrane skeleton.	SPTA1 SPTAN1	5.71e-05	4	108	2	9593709
Pubmed	Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning.	RELN LRP8	5.71e-05	4	108	2	12167620
Pubmed	The central fragment of Reelin, generated by proteolytic processing in vivo, is critical to its function during cortical plate development.	RELN LRP8	5.71e-05	4	108	2	14724251
Pubmed	Structure of a receptor-binding fragment of reelin and mutational analysis reveal a recognition mechanism similar to endocytic receptors.	RELN LRP8	5.71e-05	4	108	2	17548821
Pubmed	Human alpha spectrin II and the Fanconi anemia proteins FANCA and FANCC interact to form a nuclear complex.	SPTA1 SPTAN1	5.71e-05	4	108	2	10551855
Pubmed	Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein.	MOB1B MOB1A	5.71e-05	4	108	2	15197186
Pubmed	A mouse homologue of Strawberry Notch is transcriptionally regulated by Reelin signal.	RELN LRP8	5.71e-05	4	108	2	17045962
Pubmed	Clusterin is a ligand for apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR) and signals via the Reelin-signaling pathway.	RELN LRP8	5.71e-05	4	108	2	24381170
Pubmed	Structural basis for specific recognition of reelin by its receptors.	RELN LRP8	5.71e-05	4	108	2	20223215
Pubmed	Identification of gemin5 as a novel 7-methylguanosine cap-binding protein.	GEMIN4 DDX20	5.71e-05	4	108	2	19750007
Pubmed	The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation.	SPTA1 SPTAN1	5.71e-05	4	108	2	21566095
Pubmed	Remarkable homology among the internal repeats of erythroid and nonerythroid spectrin.	SPTA1 SPTAN1	5.71e-05	4	108	2	3862089
Pubmed	Common motifs in ETAA1 and TOPBP1 required for ATR kinase activation.	ATRIP ETAA1	5.71e-05	4	108	2	30940728
Pubmed	Crossveinless 2 regulates bone morphogenetic protein 9 in human and mouse vascular endothelium.	ACVRL1 BMPER	5.71e-05	4	108	2	22474252
Pubmed	Processing of Reelin by embryonic neurons is important for function in tissue but not in dissociated cultured neurons.	RELN LRP8	5.71e-05	4	108	2	17442808
Pubmed	Mapping of a spectrin-binding domain of human erythrocyte membrane protein 4.2.	SPTA1 SPTAN1	5.71e-05	4	108	2	12049649
Pubmed	Reelin is a ligand for lipoprotein receptors.	RELN LRP8	5.71e-05	4	108	2	10571240
Pubmed	Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation.	RELN LRP8	5.71e-05	4	108	2	10571241
Pubmed	Disruption of spectrin-like cytoskeleton in differentiating keratinocytes by PKCδ activation is associated with phosphorylated adducin.	SPTA1 SPTAN1	5.71e-05	4	108	2	22163289
Pubmed	Malformation of the radial glial scaffold in the dentate gyrus of reeler mice, scrambler mice, and ApoER2/VLDLR-deficient mice.	RELN LRP8	5.71e-05	4	108	2	12687696
Pubmed	Expression and regulation of reelin and its receptors in the enteric nervous system.	RELN LRP8	5.71e-05	4	108	2	24844606
Pubmed	Reelin receptors in developing laminated brain structures of mouse and human.	RELN LRP8	5.71e-05	4	108	2	15548227
Pubmed	Nonerythroid alphaII spectrin is required for recruitment of FANCA and XPF to nuclear foci induced by DNA interstrand cross-links.	SPTA1 SPTAN1	5.71e-05	4	108	2	12571280
Pubmed	Reelin provides an inhibitory signal in the migration of gonadotropin-releasing hormone neurons.	RELN LRP8	5.71e-05	4	108	2	16207762
Pubmed	Contribution of the Reelin signaling pathways to nociceptive processing.	RELN LRP8	5.71e-05	4	108	2	18279306
Pubmed	Differential binding of ligands to the apolipoprotein E receptor 2.	RELN LRP8	5.71e-05	4	108	2	12899622
Pubmed	Components of the reelin signaling pathway are expressed in the spinal cord.	RELN LRP8	5.71e-05	4	108	2	14750162
Pubmed	Spectrin alpha II and beta II isoforms interact with high affinity at the tetramerization site.	SPTA1 SPTAN1	5.71e-05	4	108	2	12820899
Pubmed	STIP is a critical nuclear scaffolding protein linking USP7 to p53-Mdm2 pathway regulation.	TFIP11 USP7	5.71e-05	4	108	2	26460617
Pubmed	Role for Reelin-induced cofilin phosphorylation in the assembly of sympathetic preganglionic neurons in the murine intermediolateral column.	RELN LRP8	5.71e-05	4	108	2	21039973
Pubmed	Interaction of reelin signaling and Lis1 in brain development.	RELN LRP8	9.50e-05	5	108	2	14578885
Pubmed	Reelin and cyclin-dependent kinase 5-dependent signals cooperate in regulating neuronal migration and synaptic transmission.	RELN LRP8	9.50e-05	5	108	2	14985430
Pubmed	Mutations in the Reelin pathway are associated with abnormal expression of microglial IgG FC receptors in the cerebellar cortex.	RELN LRP8	9.50e-05	5	108	2	32594343
Pubmed	A Unique "Reversed" Migration of Neurons in the Developing Claustrum.	RELN LRP8	9.50e-05	5	108	2	36631266
Pubmed	Plectin and IFAP-300K are homologous proteins binding to microtubule-associated proteins 1 and 2 and to the 240-kilodalton subunit of spectrin.	SPTA1 SPTAN1	9.50e-05	5	108	2	3027087
Pubmed	Splicing variations in the ligand-binding domain of ApoER2 results in functional differences in the binding properties to Reelin.	RELN LRP8	9.50e-05	5	108	2	19167437
Pubmed	Mice with Dab1 or Vldlr insufficiency exhibit abnormal neonatal vocalization patterns.	RELN LRP8	9.50e-05	5	108	2	27184477
Pubmed	Impact of the Reelin signaling cascade (ligands-receptors-adaptor complex) on cognition in schizophrenia.	RELN LRP8	9.50e-05	5	108	2	22419519
Pubmed	PCSK9 binds to multiple receptors and can be functionally inhibited by an EGF-A peptide.	RELN LRP8	9.50e-05	5	108	2	18675252
Pubmed	RGD-containing ankyrin externalized onto the cell surface triggers αVβ3 integrin-mediated erythrophagocytosis.	SPTA1 SPTAN1	9.50e-05	5	108	2	21406181
Pubmed	YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma.	MOB1B MOB1A	9.50e-05	5	108	2	32206709
Pubmed	Binding of manumycin A inhibits IkappaB kinase beta activity.	FXR2 IKBKB	9.50e-05	5	108	2	16319058
Pubmed	ApoER2/VLDL receptor and Dab1 in the rostral migratory stream function in postnatal neuronal migration independently of Reelin.	RELN LRP8	9.50e-05	5	108	2	17494763
Pubmed	Spectrin interacts with EVL (Enabled/vasodilator-stimulated phosphoprotein-like protein), a protein involved in actin polymerization.	SPTA1 SPTAN1	9.50e-05	5	108	2	16336193
Pubmed	Reelin controls the positioning of brainstem serotonergic raphe neurons.	RELN LRP8	1.42e-04	6	108	2	30001399
Pubmed	Localization of ApoER2, VLDLR and Dab1 in radial glia: groundwork for a new model of reelin action during cortical development.	RELN LRP8	1.42e-04	6	108	2	12586425
Interaction	HRC interactions	ZNF101 ZNF699 ZNF430 ZNF791	4.98e-08	8	106	4	int:HRC
Interaction	TRIM28 interactions	ZNF823 ZNF567 ZNF136 ZNF140 ZNF670 SPTAN1 ZFP57 ZNF101 ZNF699 ZNF331 ZNF563 ZNF430 ZNF776 ZNF878 ZNF100 L3MBTL1 ZNF780A ZNF587 ZNF81 ZNF30 ZNF418 ZNF417 ZNF738 ZNF791 ZNF669	1.29e-07	1474	106	25	int:TRIM28
Interaction	LTBP2 interactions	ZNF136 ZNF101 ZNF430 ZNF417 ZNF709 ZNF791	5.73e-06	85	106	6	int:LTBP2
Interaction	PNMA2 interactions	ZNF136 SETX ARHGAP23 CERT1 ZNF331 ZNF587 TTLL10 ZNF417 ZNF669	7.17e-06	251	106	9	int:PNMA2
Interaction	MRFAP1L1 interactions	SNAPC1 ZNF30 ATP12A IKBKB ZNF417 ZNF709	2.80e-05	112	106	6	int:MRFAP1L1
Interaction	SLC9A2 interactions	SPTA1 SPTAN1 USP7	3.01e-05	12	106	3	int:SLC9A2
Cytoband	19p13.2	ZNF823 ZNF136 ZNF177 ZNF699 ZNF442 ZNF563 ZNF878 ZNF69 ZNF700 ZNF844 ZNF709 ZNF791	3.25e-13	229	108	12	19p13.2
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	ZNF823 ZNF136 ZNF177 ZNF101 ZNF699 ZNF442 ZNF563 ZNF878 ZNF69 ZNF700 ZNF844 ZNF709 ZNF791	5.35e-08	797	108	13	chr19p13
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF567 ZNF586 ZNF175 ZNF780B ZNF571 ZFP14 ZNF404 ZNF331 ZNF776 ZNF780A ZNF587 SCN1B ZNF30 ZNF418 ZNF417	1.39e-07	1192	108	15	chr19q13
Cytoband	19q13.43	ZNF586 ZNF776 ZNF587 ZNF418 ZNF417	2.08e-06	87	108	5	19q13.43
Cytoband	19q13.12	ZNF567 ZNF571 ZFP14	6.71e-04	72	108	3	19q13.12
Cytoband	1q24	ADCY10 BRINP2	1.01e-03	20	108	2	1q24
Cytoband	19p12	ZNF430 ZNF100 ZNF738	1.28e-03	90	108	3	19p12
Cytoband	7q11.23	TRIM73 TRIM50 TRIM74	1.59e-03	97	108	3	7q11.23
Cytoband	16q22.1	CLEC18A CLEC18C TERB1	2.28e-03	110	108	3	16q22.1
Cytoband	Ensembl 112 genes in cytogenetic band chr19p12	ZNF430 ZNF100 ZNF738	3.05e-03	122	108	3	chr19p12
Cytoband	3p25.3	IRAK2 SLC6A1	5.08e-03	45	108	2	3p25.3
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF823 ZNF567 ZNF136 ZNF140 ZNF586 ZNF670 ZNF175 ZNF177 ZNF780B ZFP57 ZNF571 ZFP14 ZNF101 ZNF699 ZNF442 ZNF404 ZNF331 ZNF563 ZNF430 ZNF776 ZNF878 ZNF100 ZNF780A ZNF587 ZNF69 ZNF81 ZNF30 ZNF700 ZNF844 ZNF418 ZNF417 ZNF709 ZNF791 ZNF669	6.09e-26	718	84	34	28
GeneFamily	EF-hand domain containing\|Spectrins	SPTA1 SPTAN1	4.41e-04	7	84	2	1113
GeneFamily	MOB kinase activators\|STRIPAK complex	MOB1B MOB1A	4.41e-04	7	84	2	647
GeneFamily	C-type lectin domain family	CLEC18A CLEC18B CLEC18C	1.35e-03	47	84	3	494
Coexpression	GSE45365_CD8A_DC_VS_CD11B_DC_IFNAR_KO_UP	ZNF136 DUSP1 ZNF780B ZNF404 KCNK1 ZNF700 ZNF844	1.67e-05	195	108	7	M10001
Coexpression	GSE7568_CTRL_VS_24H_TGFB_TREATED_MACROPHAGES_WITH_IL4_AND_DEXAMETHASONE_UP	CERT1 ZNF878 ATP8A1 MOB1B N4BP1 ZNF81 IKBKB	1.97e-05	200	108	7	M363
ToppCell	MS-CD8-antiviral_CD4\|MS / Condition, Cell_class and T cell subcluster	MTMR12 TMX2 ZNF587 DDX20 ZNF700 ZNF738	7.01e-06	190	108	6	8c831c4560b8e70f92b4c15644fea39f7f7afcf2
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Papillary-5\|TCGA-Stomach / Sample_Type by Project: Shred V9	ZNF823 ZNF136 ZNF101 ZNF878 ZNF69	7.60e-06	111	108	5	eb737146969b70c619649f244998d4183237c763
ToppCell	Tracheal-NucSeq-Stromal-Chondrocytic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CLEC18A RELN CLEC18B CLEC18C COLGALT2 BMPER	9.40e-06	200	108	6	b5a54b9baf79aea01f76a161f0a39bbe87eb4945
ToppCell	Tracheal-NucSeq-Stromal-Chondrocytic-Chondrocyte\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CLEC18A RELN CLEC18B CLEC18C COLGALT2 BMPER	9.40e-06	200	108	6	f5bd0b30e478dac09f68c46b0781f5f2e7e3c693
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Alv_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SETX ARHGEF28 SPTAN1 ACVRL1 STXBP6 SCN1B	9.40e-06	200	108	6	7034f57e282982c19c13ee8ab78eabaffa069e30
Disease	Amyotrophic Lateral Sclerosis	SETX ARHGEF28 SLC6A1	8.77e-04	58	95	3	C0002736
Disease	transient cerebral ischemia (biomarker_via_orthology)	DUSP1 ACVRL1 MMP2 IKBKB	1.69e-03	157	95	4	DOID:224 (biomarker_via_orthology)
Disease	squamous cell carcinoma (is_marker_for)	DUSP1 MMP2	1.69e-03	19	95	2	DOID:1749 (is_marker_for)
Disease	Alcoholic Intoxication, Chronic	ZNF699 LRP8 SLC6A1 GEMIN4 MMP2	1.77e-03	268	95	5	C0001973
Disease	temporal lobe epilepsy (is_marker_for)	RELN SLC6A1	1.88e-03	20	95	2	DOID:3328 (is_marker_for)
Disease	sensory perception of bitter taste	MGAM TAS2R14	3.17e-03	26	95	2	GO_0050913

Protein segments in the cluster

Peptide	Gene	Start	Entry
NEASDFTRFWDSVNR	AMER3	301	Q8N944
SFWLTTVEERQQFGE	COL4A6	1651	Q14031
EETEEWRRFQADLQT	SPECC1	716	Q5M775
FSSRDEQSWFRETEI	ACVRL1	231	P37023
QTWHFEAASFEERDA	AGAP2	886	Q99490
RSSFRLQTEAQEDDW	DDX20	741	Q9UHI6
FIIDEAQFVDSTSWR	ADCY10	641	Q96PN6
VAEISESDFQEWRAV	ATP8A1	611	Q9Y2Q0
DDAFARAFQVWSDVT	MMP2	141	P08253
SDAQEFEAESWSLVV	ARHGEF28	821	Q8N1W1
FDECRFDISVNDSVW	CERT1	81	Q9Y5P4
NWSSFVDNTFAEEFT	LIMA1	706	Q9UHB6
DSVTIFFENNWQSER	FXR2	36	P51116
TVREQDQSFTALDWS	IKBKB	726	O14920
SAADVTTRFDEVFWF	INPP5E	461	Q9NRR6
LFWSEADVVQATDDF	IRAK2	196	O43187
QLFLIDNSTEFWDTD	MTMR12	336	Q9C0I1
LWFDNQIFVADTSED	ATP12A	406	P54707
FVSDQVTWDIDSQFL	MGAM	1641	O43451
EFVSDQVTWDIDSQF	MGAM	2536	O43451
AVFSVLEDDWNFLES	KCNK1	201	O00180
IEENTTTSFTWAFQR	ELAPOR1	541	Q6UXG2
TQNEWRLDEATDSFF	DCUN1D2	31	Q6PH85
TDVVDSRFLVHFDNW	L3MBTL1	436	Q9Y468
NETDWSQEFISEVTD	PEX5	136	P50542
EVFENTERTTEFWKQ	F9	76	P00740
EDLNEWVAVNTVDFF	MOB1B	51	Q7L9L4
DSWETLDQQQFFTEE	NUCB2	331	P80303
DNFESARVTEANWET	RELN	3271	P78509
IDAFTTSDFEDDWEN	ETAA1	371	Q9NY74
DVSNQDFREWFEFSP	PLA2G4E	521	Q3MJ16
DFAESWRVESNEFCN	BMPER	521	Q8N8U9
ADISSWFNEAIDFID	DUSP1	231	P28562
WTVDDTTFQALFLEA	FAM118B	251	Q9BPY3
GNEWIFFSTDEITTR	KLB	11	Q86Z14
EEAQKSFVDSWRQRS	ATRIP	291	Q8WXE1
TDHNVDNTTEIFREW	COLGALT2	91	Q8IYK4
DFEQDQNASEEWITF	HELB	506	Q8NG08
NRRDVEAWFNTQTEE	KRT36	276	O76013
VFWTDLENEAIFSAN	LRP8	641	Q14114
FWLDIIFEATNEVTN	MAP3K15	511	Q6ZN16
SWFEAEDEVDNRTDN	GPRASP1	971	Q5JY77
DETEFRNFIVWLEDQ	RTRAF	21	Q9Y224
SFFISVWTSERLEEN	TAS2R14	246	Q9NYV8
DSEVWLDAATQIFFS	SLC6A1	281	P30531
QFNWTEEDTDRTCFH	TAF1B	476	Q53T94
EDLNEWIAVNTVDFF	MOB1A	51	Q9H8S9
EDFAEWLLFFTNTEN	MICU2	281	Q8IYU8
FEFESSSEVFSVWQD	SETX	1081	Q7Z333
LQSNEWTDSFRRFVD	TAOK3	241	Q9H2K8
TDSVRFEDFTELWRN	SNAPC1	21	Q16533
LETFSESRISEWTFQ	SSUH2	116	Q9Y2M2
SWATHNRQFEESEEF	BRINP2	326	Q9C0B6
VQFSVASDDNSEFWL	B4GALNT4	181	Q76KP1
TNEVIDSDFETRNFW	CLEC18A	356	A5D8T8
TNEVIDSDFETRNFW	CLEC18B	356	Q6UXF7
TNEVIDSDFETRNFW	CLEC18C	356	Q8NCF0
NESDVFSWVIRREFQ	TRIM74	166	Q86UV6
AVSWTFSEENVIREF	TMX2	241	Q9Y320
FEDVAIAFSQQEWES	ZNF30	16	P17039
VSFNDVTVDFTQEEW	ZNF567	6	Q8N184
FEDVAVNFTQEEWAL	ZNF823	6	P16415
TFRDVAIEFSLEEWQ	ZNF100	36	Q8IYN0
TFEDVAVNFSLEEWS	ZNF586	16	Q9NXT0
DLLFENAFDQWVAST	STXBP6	101	Q8NFX7
TFRDVVIEFSQEEWQ	ZNF738	36	Q8NE65
FEDVAVNFTQEEWTL	ZNF700	26	Q9H0M5
FEDVSVSFSQEEWAL	ZNF791	6	Q3KP31
FEDVDVNFTQEEWAL	ZNF136	6	P52737
FQEVAVDFSQEEWAL	ZNF177	16	Q13360
VTFEDVAVNFTQEEW	ZFP57	16	Q9NU63
VETLIQHSDWFFSDE	ARHGAP23	1086	Q9P227
SAFNSWFENAEEDLT	SPTAN1	2101	Q13813
TFEDVAVNFSQEEWC	ZNF587	16	Q96SQ5
RSETNAETFTEWTFR	SCN1B	46	Q07699
TFEDVAVNFSQEEWC	ZNF417	16	Q8TAU3
VTFADVAIDFSQEEW	ZNF331	6	Q9NQX6
RFNTSIRDFEFWLSE	SPTA1	1611	P02549
VTFRDVAIDFSQEEW	ZNF780A	6	O75290
VTFRDVAIDFSQEEW	ZNF780B	6	Q9Y6R6
FEDVAVNFTQEEWAL	ZNF709	6	Q8N972
FEDVAVNFTQEEWSL	ZNF844	6	Q08AG5
LTFSDVAIDFSQEEW	ZNF404	6	Q494X3
TFRDVAIEFSLEEWQ	ZNF430	36	Q9H8G1
FEDVAVNFTQEEWAL	ZNF442	31	Q9H7R0
FEDVAVNFTQEEWAL	ZNF563	6	Q8TA94
FEDVAVNFTQEEWAL	ZNF101	6	Q8IZC7
AFEDVAVNFSQEEWS	ZNF418	6	Q8TF45
FDDVAVNFTQEEWAL	ZNF69	26	Q9UC07
VTFRDVAIDFSQEEW	ZNF140	6	P52738
NESDVFSWVIRREFQ	TRIM73	166	Q86UV7
VTFRDVAIDFSQEEW	ZFP14	6	Q9HCL3
FEDVAVDFTQEEWAL	ZNF699	21	Q32M78
NESDVFSWVIRREFQ	TRIM50	166	Q86XT4
EREAFFTLFDETQIW	TTLL10	296	Q6ZVT0
DDTSWRSEATFQFTV	USP7	61	Q93009
VTFRDVAIDFSQEEW	ZNF571	6	Q7Z3V5
ELFEDLTWFLSNDSN	TERB1	101	Q8NA31
RENFEITDWDLQNEF	TFIP11	21	Q9UBB9
QAFSEPENVDDFWSS	USP13	546	Q92995
FAESFQSWQDTLVET	VWA3A	1001	A6NCI4
DVTVDFSREEWQQLD	ZNF175	31	Q9Y473
VTVDFSREEWQQLDS	ZNF81	26	P51508
AFEDVAVNFTQEEWA	ZNF669	91	Q96BR6
FEDVAVAFTQEEWAL	ZNF670	6	Q9BS34
FEDVAVNFTQEEWAL	ZNF878	6	C9JN71
FEDVAVNFSQEEWSL	ZNF776	16	Q68DI1
SDTETRWQEDLFFSV	GEMIN4	86	P57678
TNDNFREFVNESVSW	N4BP1	721	O75113