Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	poly(A) RNA polymerase activity	TENT4B PAPOLA PAPOLG	1.38e-05	12	81	3	GO:1990817
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	ERBB3 TENT4B LATS2 PAPOLA PIK3R3 STYK1 AAK1 SYK FGFR2 CDK11B ACVR1C PXK PAPOLG	9.65e-05	938	81	13	GO:0016772
GeneOntologyMolecularFunction	neuregulin binding	ERBB3 ITGB3	2.41e-04	6	81	2	GO:0038132
GeneOntologyMolecularFunction	adenylyltransferase activity	TENT4B PAPOLA PAPOLG	2.66e-04	31	81	3	GO:0070566
GeneOntologyMolecularFunction	promoter-specific chromatin binding	SETDB1 IKZF3 NIPBL DNMT1	3.62e-04	83	81	4	GO:1990841
GeneOntologyMolecularFunction	armadillo repeat domain binding	STRN3 STRN4	5.74e-04	9	81	2	GO:0070016
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	ERBB3 LATS2 PIK3R3 STYK1 AAK1 SYK FGFR2 CDK11B ACVR1C PXK	5.78e-04	709	81	10	GO:0016773
GeneOntologyMolecularFunction	protein kinase activity	ERBB3 LATS2 STYK1 AAK1 SYK FGFR2 CDK11B ACVR1C PXK	7.16e-04	600	81	9	GO:0004672
GeneOntologyMolecularFunction	protein domain specific binding	STRN3 SCN2A STRN4 SYK OCLN ADGRL2 BHLHE40 NIPBL CRK DNMT1 SON	7.89e-04	875	81	11	GO:0019904
GeneOntologyMolecularFunction	kinase activity	ERBB3 LATS2 PIK3R3 STYK1 AAK1 SYK FGFR2 CDK11B ACVR1C PXK	1.02e-03	764	81	10	GO:0016301
GeneOntologyMolecularFunction	phosphotyrosine residue binding	PIK3R3 SYK CRK	1.16e-03	51	81	3	GO:0001784
MousePheno	lethality throughout fetal growth and development	JUP ERBB3 SEC24B KLF3 FGFR2 CUL7 ADGRL2 VIRMA TCF7L1 CRK	3.89e-05	435	67	10	MP:0006208
MousePheno	abnormal trophoblast layer morphology	JUP FGFR2 LDOC1 CUL7 ITGB3 VIRMA NIPBL	6.52e-05	211	67	7	MP:0005031
MousePheno	abnormal naive B cell morphology	IKZF3 SON	6.77e-05	3	67	2	MP:0008184
Domain	NTP_transf_2	TENT4B PAPOLA PAPOLG	1.22e-05	11	80	3	PF01909
Domain	Polymerase_NTP_transf_dom	TENT4B PAPOLA PAPOLG	1.22e-05	11	80	3	IPR002934
Domain	TBP_CS	TBPL2 TBP	1.81e-05	2	80	2	IPR030491
Domain	TBP_eukaryotic	TBPL2 TBP	1.81e-05	2	80	2	IPR033710
Domain	Tyr_Pase_non-rcpt_typ-14/21	PTPN14 PTPN21	1.81e-05	2	80	2	IPR014392
Domain	Striatin	STRN3 STRN4	5.42e-05	3	80	2	PF08232
Domain	-	PAPOLA PAPOLG	5.42e-05	3	80	2	3.30.70.590
Domain	TFIID	TBPL2 TBP	5.42e-05	3	80	2	PS00351
Domain	TBP	TBPL2 TBP	5.42e-05	3	80	2	PF00352
Domain	PAP_central	PAPOLA PAPOLG	5.42e-05	3	80	2	PF04928
Domain	PAP_RNA-bind	PAPOLA PAPOLG	5.42e-05	3	80	2	PF04926
Domain	PolA_pol_cen_dom	PAPOLA PAPOLG	5.42e-05	3	80	2	IPR007012
Domain	PolA_pol_RNA-bd_dom	PAPOLA PAPOLG	5.42e-05	3	80	2	IPR007010
Domain	TBP	TBPL2 TBP	5.42e-05	3	80	2	IPR000814
Domain	PolyA_polymerase	PAPOLA PAPOLG	5.42e-05	3	80	2	IPR014492
Domain	Striatin_N	STRN3 STRN4	5.42e-05	3	80	2	IPR013258
Domain	NuclTrfase_I_C	PAPOLA PAPOLG	5.42e-05	3	80	2	IPR011068
Domain	Pkinase_Tyr	ERBB3 STYK1 SYK FGFR2 ACVR1C	2.31e-04	129	80	5	PF07714
Domain	Prot_kinase_dom	ERBB3 LATS2 STYK1 AAK1 SYK FGFR2 CDK11B ACVR1C PXK	2.40e-04	489	80	9	IPR000719
Domain	PROTEIN_KINASE_DOM	ERBB3 LATS2 STYK1 AAK1 SYK FGFR2 CDK11B ACVR1C PXK	2.54e-04	493	80	9	PS50011
Domain	Beta2_adaptin/TBP_C_dom	TBPL2 TBP	2.69e-04	6	80	2	IPR012295
Domain	-	TBPL2 TBP	2.69e-04	6	80	2	3.30.310.10
Domain	Ser-Thr/Tyr_kinase_cat_dom	ERBB3 STYK1 SYK FGFR2 ACVR1C	3.16e-04	138	80	5	IPR001245
Domain	zf-CW	KDM1B MORC4	3.75e-04	7	80	2	PF07496
Domain	Znf_CW	KDM1B MORC4	3.75e-04	7	80	2	IPR011124
Domain	ZF_CW	KDM1B MORC4	3.75e-04	7	80	2	PS51050
Domain	Kinase-like_dom	ERBB3 LATS2 STYK1 AAK1 SYK FGFR2 CDK11B ACVR1C PXK	5.08e-04	542	80	9	IPR011009
Domain	PROTEIN_KINASE_ATP	ERBB3 LATS2 STYK1 AAK1 SYK FGFR2 CDK11B ACVR1C	7.72e-04	459	80	8	PS00107
Domain	PROTEIN_KINASE_TYR	ERBB3 STYK1 SYK FGFR2	7.99e-04	97	80	4	PS00109
Domain	Tyr_kinase_AS	ERBB3 STYK1 SYK FGFR2	7.99e-04	97	80	4	IPR008266
Domain	HEAT	JUP NIPBL NCAPG2	1.97e-03	58	80	3	IPR000357
Domain	-	JUP CUL7 NIPBL NCAPG2 TBP	2.65e-03	222	80	5	1.25.10.10
Domain	FERM_CS	PTPN14 PTPN21	4.70e-03	24	80	2	IPR019747
Domain	FERM_C	PTPN14 PTPN21	5.51e-03	26	80	2	PF09380
Domain	G-protein_beta_WD-40_rep	STRN3 STRN4 WDR17	5.81e-03	85	80	3	IPR020472
Domain	FERM_C	PTPN14 PTPN21	5.93e-03	27	80	2	SM01196
Domain	FERM_PH-like_C	PTPN14 PTPN21	5.93e-03	27	80	2	IPR018980
Domain	ARM-like	JUP CUL7 NIPBL NCAPG2 TBP	6.06e-03	270	80	5	IPR011989
Domain	TyrKc	ERBB3 SYK FGFR2	6.39e-03	88	80	3	SM00219
Domain	Tyr_kinase_cat_dom	ERBB3 SYK FGFR2	6.39e-03	88	80	3	IPR020635
Pubmed	Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.	JUP ERBB3 PIK3R3 SYK FGFR2 ACVR1C OCLN CRK	2.79e-06	371	82	8	25241761
Pubmed	FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival.	ERBB3 FGFR2	5.49e-06	2	82	2	18381441
Pubmed	Overexpression of P-selectin glycoprotein ligand-1 enhances adhesive properties of endothelial progenitor cells through Syk activation.	SELPLG SYK	5.49e-06	2	82	2	20705591
Pubmed	Anaplasma phagocytophilum PSGL-1-independent infection does not require Syk and leads to less efficient AnkA delivery.	SELPLG SYK	5.49e-06	2	82	2	18485118
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	JUP AMER1 PTPN14 CEP112 EXPH5 KIAA0232 SEC24B AAK1 PTPN21 VIRMA DNMT1	5.68e-06	861	82	11	36931259
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	SETDB1 IKZF3 PTPN14 CDK11B CUL7 MORC4 CRK KNL1 PAPOLG	1.04e-05	588	82	9	38580884
Pubmed	TBP/TFIID-dependent activation of MyoD target genes in skeletal muscle cells.	TBPL2 TBP	1.64e-05	3	82	2	26880551
Pubmed	Oncogenic PAX6 elicits CDK4/6 inhibitor resistance by epigenetically inactivating the LATS2-Hippo signaling pathway.	LATS2 DNMT1	1.64e-05	3	82	2	34459131
Pubmed	Anaplasma phagocytophilum specifically induces tyrosine phosphorylation of ROCK1 during infection.	SELPLG SYK	1.64e-05	3	82	2	17346310
Pubmed	Activation of Endogenous Retroviruses in Dnmt1(-/-) ESCs Involves Disruption of SETDB1-Mediated Repression by NP95 Binding to Hemimethylated DNA.	SETDB1 DNMT1	1.64e-05	3	82	2	27151458
Pubmed	Cooperation between AlphavBeta3 integrin and the fibroblast growth factor receptor enhances proliferation of Hox-overexpressing acute myeloid leukemia cells.	FGFR2 ITGB3	1.64e-05	3	82	2	27340869
Pubmed	SON is an essential RNA splicing factor promoting ErbB2 and ErbB3 expression in breast cancer.	ERBB3 SON	1.64e-05	3	82	2	39313574
Pubmed	Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton.	SYK ITGB3	1.64e-05	3	82	2	11940607
Pubmed	Maintenance DNA methylation in pre-meiotic germ cells regulates meiotic prophase by facilitating homologous chromosome pairing.	SETDB1 DNMT1	1.64e-05	3	82	2	33998651
Pubmed	Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1.	PIK3R3 SYK CRK	2.47e-05	24	82	3	20624904
Pubmed	Crystal structure of a beta-catenin/Tcf complex.	JUP TCF7L1	3.28e-05	4	82	2	11136974
Pubmed	Platelet alpha IIb-beta 3 integrin engagement induces the tyrosine phosphorylation of Cbl and its association with phosphoinositide 3-kinase and Syk.	SYK ITGB3	3.28e-05	4	82	2	11042121
Pubmed	Zinedin, SG2NA, and striatin are calmodulin-binding, WD repeat proteins principally expressed in the brain.	STRN3 STRN4	3.28e-05	4	82	2	10748158
Pubmed	DNA methylation and SETDB1/H3K9me3 regulate predominantly distinct sets of genes, retroelements, and chimeric transcripts in mESCs.	SETDB1 DNMT1	3.28e-05	4	82	2	21624812
Pubmed	The PSGL-1-L-selectin signaling complex regulates neutrophil adhesion under flow.	SELPLG SYK	3.28e-05	4	82	2	24127491
Pubmed	Long noncoding RNA DDX11-AS1 epigenetically represses LATS2 by interacting with EZH2 and DNMT1 in hepatocellular carcinoma.	LATS2 DNMT1	3.28e-05	4	82	2	31097223
Pubmed	Tat-dependent occlusion of the HIV poly(A) site.	PAPOLA PAPOLG	3.28e-05	4	82	2	8491200
Pubmed	Comprehensive binary interaction mapping of SH2 domains via fluorescence polarization reveals novel functional diversification of ErbB receptors.	ERBB3 PIK3R3 SYK CRK	3.41e-05	77	82	4	22973453
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	PTPN14 LATS2 EXPH5 SEC24B SEC23IP OCLN	3.82e-05	263	82	6	34702444
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	STRN3 TENT4B CNOT6L SEC24B AAK1 STRN4 KDM1B ASCC3 VIRMA NIPBL MOV10 SON TBP	4.63e-05	1497	82	13	31527615
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	JUP PTPN14 SEC24B SEC23IP STRN4 ASCC3 CRK DNMT1	4.69e-05	549	82	8	38280479
Pubmed	The armadillo repeat domain of the APC tumor suppressor protein interacts with Striatin family members.	STRN3 STRN4	5.47e-05	5	82	2	18502210
Pubmed	miR-148a-3p represses proliferation and EMT by establishing regulatory circuits between ERBB3/AKT2/c-myc and DNMT1 in bladder cancer.	ERBB3 DNMT1	5.47e-05	5	82	2	27906180
Pubmed	Spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1.	SELPLG SYK	5.47e-05	5	82	2	17543554
Pubmed	Developmental and cell type-specific regulation of core promoter transcription factors in germ cells of frogs and mice.	TBPL2 TBP	5.47e-05	5	82	2	16412700
Pubmed	Heregulin targets gamma-catenin to the nucleolus by a mechanism dependent on the DF3/MUC1 oncoprotein.	JUP ERBB3	5.47e-05	5	82	2	12939402
Pubmed	ITAM-based interaction of ERM proteins with Syk mediates signaling by the leukocyte adhesion receptor PSGL-1.	SELPLG SYK	5.47e-05	5	82	2	12387735
Pubmed	Imaging filopodia dynamics in the mouse blastocyst.	ERBB3 FGFR2	5.47e-05	5	82	2	14697354
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	SETDB1 JUP SEC23IP ASCC3 MORC4 CRK KNL1	6.03e-05	418	82	7	34709266
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	SETDB1 EYA4 AMER1 PTPN14 CNOT6L FAM210A SEC24B SEC23IP AAK1 CDH23 NCAPG2 MOV10	6.10e-05	1321	82	12	27173435
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	SETDB1 PTPN14 PIK3R3 KDM1B CUL7 ASCC3 ADGRL2 TCF7L1 KNL1 SON TBP	6.17e-05	1116	82	11	31753913
Pubmed	A quantitative protein interaction network for the ErbB receptors using protein microarrays.	ERBB3 PIK3R3 SYK CRK	6.29e-05	90	82	4	16273093
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	STRN3 JUP PAPOLA SEC24B SEC23IP AAK1 NIPBL DNMT1 KNL1 SON	6.93e-05	934	82	10	33916271
Pubmed	Functional proteomics mapping of a human signaling pathway.	SETDB1 JUP PAPOLA EXPH5 ASCC3 MORC4 KNL1 SON	7.84e-05	591	82	8	15231748
Pubmed	Structural and functional basis of a role for CRKL in a fibroblast growth factor 8-induced feed-forward loop.	FGFR2 CRK	8.19e-05	6	82	2	19307307
Pubmed	The N-terminal SH2 domain of Syk is required for (hem)ITAM, but not integrin, signaling in mouse platelets.	SYK ITGB3	8.19e-05	6	82	2	25352128
Pubmed	Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22.	PIK3R3 SYK	8.19e-05	6	82	2	8647200
Pubmed	Analysis of TATA-binding protein 2 (TBP2) and TBP expression suggests different roles for the two proteins in regulation of gene expression during oogenesis and early mouse development.	TBPL2 TBP	8.19e-05	6	82	2	17641088
Pubmed	Thrombspondin acts via integrin-associated protein to activate the platelet integrin alphaIIbbeta3.	SYK ITGB3	8.19e-05	6	82	2	9169439
Pubmed	Direct binding of the EGF-like domain of neuregulin-1 to integrins ({alpha}v{beta}3 and {alpha}6{beta}4) is involved in neuregulin-1/ErbB signaling.	ERBB3 ITGB3	8.19e-05	6	82	2	20682778
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	STRN3 PAPOLA AAK1 CDK11B VIRMA NIPBL DNMT1 SON PAPOLG	8.80e-05	774	82	9	15302935
Pubmed	ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.	STRN3 JUP PAPOLA SEC23IP NCAPG2 MOV10 GGT7	9.69e-05	451	82	7	36168627
Pubmed	The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin.	JUP PTPN14	1.14e-04	7	82	2	12808048
Pubmed	Mandibular dysmorphology due to abnormal embryonic osteogenesis in FGFR2-related craniosynostosis mice.	FGFR2 ITGB3	1.14e-04	7	82	2	31064775
Pubmed	β-catenin and γ-catenin are dispensable for T lymphocytes and AML leukemic stem cells.	JUP TCF7L1	1.14e-04	7	82	2	32820720
Pubmed	Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer.	ERBB3 STYK1 FGFR2	1.17e-04	40	82	3	30898150
Pubmed	Human transcription factor protein interaction networks.	SETDB1 JUP EYA4 IKZF3 SEC24B KLF3 KDM1B CUL7 MORC4 NIPBL MOV10 TBP	1.28e-04	1429	82	12	35140242
Pubmed	Activation of Epstein-Barr virus/C3d receptor (gp140, CR2, CD21) on human B lymphoma cell surface triggers Cbl tyrosine phosphorylation, its association with p85 subunit, Crk-L and Syk and its dissociation with Vav.	SYK CRK	1.52e-04	8	82	2	16289966
Pubmed	Cell-junctional and cytoskeletal organization in mouse blastocysts lacking E-cadherin.	JUP OCLN	1.52e-04	8	82	2	9187087
Pubmed	PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling.	SELPLG SYK	1.52e-04	8	82	2	18794338
Pubmed	BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion.	JUP SEC23IP AAK1 ASCC3 CRK	1.63e-04	216	82	5	31519766
Pubmed	USP7 Regulates Cytokinesis through FBXO38 and KIF20B.	MORC4 NCAPG2 DNMT1 KNL1	1.68e-04	116	82	4	30804394
Pubmed	RNA binding protein RBM46 regulates mitotic-to-meiotic transition in spermatogenesis.	CNOT6L MOV10	1.96e-04	9	82	2	36001654
Pubmed	beta-Catenin protects the epidermis from mechanical stresses.	JUP OCLN	1.96e-04	9	82	2	23816618
Pubmed	ABL2 suppresses FLT3-ITD-induced cell proliferation through negative regulation of AKT signaling.	SYK CRK	1.96e-04	9	82	2	28086240
Pubmed	A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.	AMER1 BHLHE40 MOV10 KNL1 SON	2.27e-04	232	82	5	25515538
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	JUP TCAF1 AMER1 CNOT6L PAPOLA FAM210A CEP112 ANKRD12 KDM1B EZHIP	2.33e-04	1084	82	10	11544199
Pubmed	Tyrosine phosphorylation of plakoglobin causes contrary effects on its association with desmosomes and adherens junction components and modulates beta-catenin-mediated transcription.	JUP TBP	2.44e-04	10	82	2	14517306
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	JUP SEC24B SEC23IP AAK1 ASCC3 OCLN ADGRL2 CRK	2.69e-04	708	82	8	39231216
Pubmed	Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.	TENT4B SEC23IP FAHD1 CRK DNMT1 KNL1 TBP	2.69e-04	533	82	7	25544563
Pubmed	The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.	JUP ERBB3 PIK3R3 CRK	2.92e-04	134	82	4	24658140
Pubmed	A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype.	SETDB1 DNMT1	2.98e-04	11	82	2	24623306
Pubmed	The murine gene, Traube, is essential for the growth of preimplantation embryos.	FGFR2 OCLN	2.98e-04	11	82	2	11071758
Pubmed	Multidimensional Proteomics Reveals a Role of UHRF2 in the Regulation of Epithelial-Mesenchymal Transition (EMT).	CDK11B NCAPG2 DNMT1	3.03e-04	55	82	3	27114453
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	SETDB1 CNOT6L SEC23IP CDK11B DNMT1 KNL1 GGT7 PAPOLG	3.39e-04	733	82	8	34672954
Pubmed	Neuropilins guide preganglionic sympathetic axons and chromaffin cell precursors to establish the adrenal medulla.	SEMA3F ERBB3	3.57e-04	12	82	2	30237243
Pubmed	The ins and outs of HIV-1 Tat.	DPP4 ITGB3	3.57e-04	12	82	2	21951552
Pubmed	Epigenetic regulation of surfactant protein A gene (SP-A) expression in fetal lung reveals a critical role for Suv39h methyltransferases during development and hypoxia.	SETDB1 TBP	3.57e-04	12	82	2	21402781
Pubmed	Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.	JUP EYA4 IKZF3 ST3GAL5 LDOC1 BHLHE40 NR1H4 CRK	3.67e-04	742	82	8	26871637
Pubmed	Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.	STRN3 JUP PTPN14 LATS2 STRN4 DNMT1	3.69e-04	399	82	6	37536630
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	TCAF1 SEC24B SEC23IP ASCC3 OCLN ADGRL2 NCAPG2 DNMT1 GGT7	3.78e-04	942	82	9	31073040
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	JUP ERBB3 SEC24B AAK1 OCLN ADGRL2 CRK	3.82e-04	565	82	7	25468996
Pubmed	MEKK2 and MEKK3 orchestrate multiple signals to regulate Hippo pathway.	STRN3 LATS2	4.21e-04	13	82	2	33571521
Pubmed	Genetic variation in 1253 immune and inflammation genes and risk of non-Hodgkin lymphoma.	SELPLG ITGB3	4.21e-04	13	82	2	17827388
Pubmed	HectD1 E3 ligase modifies adenomatous polyposis coli (APC) with polyubiquitin to promote the APC-axin interaction.	STRN3 STRN4	4.21e-04	13	82	2	23277359
Pubmed	Gene array identification of Ipf1/Pdx1-/- regulated genes in pancreatic progenitor cells.	ERBB3 FGFR2	4.21e-04	13	82	2	18036209
Pubmed	Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung.	FGFR2 TCF7L1	4.21e-04	13	82	2	15907834
Pubmed	UGT1A1 is a major locus influencing bilirubin levels in African Americans.	UGT1A6 ADGRL2	4.21e-04	13	82	2	22085899
Pubmed	JAGGED1/NOTCH3 activation promotes aortic hypermuscularization and stenosis in elastin deficiency.	ITGB3 DNMT1	4.21e-04	13	82	2	34990407
Pubmed	USP9X Deubiquitylates DVL2 to Regulate WNT Pathway Specification.	PTPN14 SEC23IP PTPN21	4.32e-04	62	82	3	31340145
Pubmed	Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.	SEC23IP ASCC3 ZNF654 BSX	4.37e-04	149	82	4	25231870
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	STRN3 TCAF1 SYT3 SEC23IP AAK1 STRN4 VIRMA NIPBL DNMT1	4.43e-04	963	82	9	28671696
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	JUP PTPN14 PIK3R3 SEC23IP OCLN ADGRL2	4.90e-04	421	82	6	36976175
Pubmed	FoxO6 regulates Hippo signaling and growth of the craniofacial complex.	LATS2 FOXO6	4.91e-04	14	82	2	30286078
Pubmed	ERBB3-mediated regulation of Bergmann glia proliferation in cerebellar lamination.	ERBB3 CRK	4.91e-04	14	82	2	25564653
Pubmed	Deterministic and stochastic allele specific gene expression in single mouse blastomeres.	PIK3R3 KLF3 FGFR2 ACVR1C TCF7L1 DNMT1	5.08e-04	424	82	6	21731673
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	STRN3 JUP TCAF1 FAM210A STRN4 KDM1B ASCC3 DNMT1 TBP	6.02e-04	1005	82	9	19615732
Pubmed	DYRK1a mediates BAFF-induced noncanonical NF-κB activation to promote autoimmunity and B-cell leukemogenesis.	SEC24B SEC23IP AAK1	6.17e-04	70	82	3	34255829
Pubmed	A high-throughput candidate gene mutation screen in lymphoproliferative and myeloproliferative neoplasias.	STYK1 SYK	6.45e-04	16	82	2	19464057
Pubmed	Perinatal lethality and endothelial cell abnormalities in several vessel compartments of fibulin-1-deficient mice.	SELPLG OCLN	6.45e-04	16	82	2	11564885
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	STRN3 AMER1 PTPN14 LATS2 STRN4 CUL7	6.62e-04	446	82	6	24255178
Pubmed	Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome.	PIK3R3 SYK CRK	6.98e-04	73	82	3	24728074
Pubmed	Association analyses identify three susceptibility Loci for vitiligo in the Chinese Han population.	ERBB3 CDH23	7.30e-04	17	82	2	22951725
Pubmed	Ubiquitin Specific Peptidase 15 (USP15) suppresses glioblastoma cell growth via stabilization of HECTD1 E3 ligase attenuating WNT pathway activity.	STRN3 STRN4	7.30e-04	17	82	2	29299163
Pubmed	Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling.	JUP AMER1	7.30e-04	17	82	2	17510365
Interaction	PIK3R1 interactions	SELPLG DPP4 JUP ERBB3 IKZF3 PIK3R3 STYK1 SYK FGFR2 OCLN VIRMA PXK CRK	1.12e-08	412	82	13	int:PIK3R1
Interaction	PIK3R2 interactions	DPP4 ERBB3 IKZF3 PIK3R3 STYK1 SYK FGFR2 OCLN CRK MOV10	3.22e-08	230	82	10	int:PIK3R2
Interaction	SEC24B interactions	DPP4 EYA4 SEC24B SEC23IP STYK1 AAK1 FGFR2 OCLN VIRMA	5.71e-07	240	82	9	int:SEC24B
Interaction	SH2D2A interactions	ERBB3 PIK3R3 SYK KDM1B CRK	2.20e-06	52	82	5	int:SH2D2A
Interaction	APC interactions	SETDB1 STRN3 JUP AMER1 LATS2 EXPH5 STRN4 OCLN VIRMA DNMT1	3.97e-06	389	82	10	int:APC
Interaction	ZFYVE9 interactions	DPP4 JUP STYK1 FGFR2 OCLN VIRMA	4.65e-06	106	82	6	int:ZFYVE9
Interaction	WWC2 interactions	PTPN14 LATS2 PTPN21 VIRMA	4.84e-06	28	82	4	int:WWC2
Interaction	GAB1 interactions	JUP PIK3R3 STYK1 SYK OCLN VIRMA CRK	8.11e-06	178	82	7	int:GAB1
Interaction	YWHAG interactions	JUP AMER1 PTPN14 LATS2 FOXO6 CEP112 EXPH5 KIAA0232 SEC24B AAK1 CDK11B PTPN21 CUL7 VIRMA CRK DNMT1 SON	9.07e-06	1248	82	17	int:YWHAG
Interaction	PTK2B interactions	ERBB3 SYK FGFR2 ITGB3 VIRMA CRK	9.07e-06	119	82	6	int:PTK2B
Interaction	CEP295 interactions	AMER1 LATS2 FGFR2 ASCC3 VIRMA	1.04e-05	71	82	5	int:CEP295
Interaction	ITGA5 interactions	TXNDC16 CDH23 FGFR2 ADAM32 ITGB3 VIRMA	1.32e-05	127	82	6	int:ITGA5
Interaction	SOBP interactions	EYA4 KLF3 VIRMA	1.39e-05	12	82	3	int:SOBP
Interaction	VBP1 interactions	EYA4 IKZF3 PTPN14 PIK3R3 SEC24B PTPN21 VIRMA	1.90e-05	203	82	7	int:VBP1
Interaction	MET interactions	DPP4 ERBB3 LATS2 PIK3R3 SYK WDR17 VIRMA CRK	2.37e-05	290	82	8	int:MET
Interaction	ERBB2 interactions	JUP ERBB3 LATS2 PIK3R3 SEC24B STYK1 SYK FGFR2 OCLN VIRMA CRK	2.59e-05	589	82	11	int:ERBB2
Interaction	STXBP4 interactions	PTPN14 LATS2 STRN4 PTPN21 VIRMA	2.65e-05	86	82	5	int:STXBP4
Interaction	RALGAPA1 interactions	DPP4 ERBB3 STYK1 OCLN VIRMA	2.80e-05	87	82	5	int:RALGAPA1
Interaction	TAF3 interactions	TBPL2 KLF3 BHLHE40 VIRMA TBP	2.96e-05	88	82	5	int:TAF3
Interaction	HDAC1 interactions	SETDB1 JUP IKZF3 LATS2 PAPOLA SEC23IP SYK ASCC3 MORC4 BHLHE40 VIRMA CRK DNMT1 KNL1 TBP	3.57e-05	1108	82	15	int:HDAC1
Interaction	CRKL interactions	ERBB3 EYA4 SYK FGFR2 CUL7 CRK MOV10	3.89e-05	227	82	7	int:CRKL
Interaction	WWC1 interactions	PTPN14 LATS2 PTPN21 VIRMA MOV10	4.07e-05	94	82	5	int:WWC1
Interaction	FER interactions	JUP ERBB3 PIK3R3 CRK	5.08e-05	50	82	4	int:FER
Interaction	QSER1 interactions	EYA4 SEC24B AAK1 KLF3 VIRMA	5.48e-05	100	82	5	int:QSER1
Interaction	MAP4K5 interactions	DPP4 SETDB1 TCAF1 OCLN CRK	6.03e-05	102	82	5	int:MAP4K5
Interaction	NFYA interactions	JUP TCAF1 MOV10 TBP PAPOLG	6.92e-05	105	82	5	int:NFYA
Interaction	MAP4K4 interactions	TBPL2 STRN3 CNOT6L STYK1 STRN4 OCLN VIRMA	7.91e-05	254	82	7	int:MAP4K4
Interaction	RFX7 interactions	EYA4 KLF3 VIRMA	8.19e-05	21	82	3	int:RFX7
Interaction	FIRRE interactions	VIRMA MOV10	9.76e-05	4	82	2	int:FIRRE
Interaction	MIF4GD-DT interactions	VIRMA MOV10	9.76e-05	4	82	2	int:MIF4GD-DT
Interaction	SNORA8 interactions	VIRMA MOV10	9.76e-05	4	82	2	int:SNORA8
Interaction	DOK1 interactions	SYK COLGALT2 ITGB3 CRK	9.77e-05	59	82	4	int:DOK1
Interaction	PPIP5K2 interactions	EYA4 SEC24B AAK1 VIRMA	1.26e-04	63	82	4	int:PPIP5K2
Interaction	YWHAH interactions	JUP AMER1 PTPN14 LATS2 FOXO6 CEP112 EXPH5 KIAA0232 SEC24B AAK1 PTPN21 VIRMA CRK DNMT1	1.32e-04	1102	82	14	int:YWHAH
Interaction	CEP192 interactions	LATS2 CNOT6L FGFR2 KDM1B VIRMA MOV10	1.33e-04	192	82	6	int:CEP192
Interaction	HSH2D interactions	ERBB3 PIK3R3 CRK	1.40e-04	25	82	3	int:HSH2D
Interaction	YES1 interactions	DPP4 ERBB3 IKZF3 SYT3 PIK3R3 ANKRD12 CUL7 OCLN	1.43e-04	375	82	8	int:YES1
Interaction	EPHA2 interactions	JUP PTPN14 LATS2 PIK3R3 SEC24B SEC23IP STYK1 FGFR2 OCLN ADGRL2 ITGB3	1.54e-04	719	82	11	int:EPHA2
Interaction	LYN interactions	DPP4 JUP ERBB3 PTPN14 PIK3R3 SYK CDH23 FGFR2 OCLN ADGRL2 VIRMA	1.56e-04	720	82	11	int:LYN
Interaction	KIT interactions	ERBB3 PIK3R3 SYK FGFR2 CRK	1.58e-04	125	82	5	int:KIT
Interaction	GHRH interactions	DPP4 CDH23	1.62e-04	5	82	2	int:GHRH
Interaction	DDX11 interactions	CDH23 NIPBL DNMT1 GGT7	1.70e-04	68	82	4	int:DDX11
Interaction	PDGFRA interactions	SEMA3F ERBB3 LATS2 PIK3R3 SEC24B TXNDC16 ITGB3 CRK	1.71e-04	385	82	8	int:PDGFRA
Interaction	MAP4K1 interactions	STRN4 SYK CUL7 TMEM101 CRK	1.90e-04	130	82	5	int:MAP4K1
Interaction	TCF3 interactions	TCAF1 EYA4 SEC23IP COLGALT2 BHLHE40 DNMT1 SON	2.00e-04	295	82	7	int:TCF3
Interaction	YWHAB interactions	PTPN14 FOXO6 CEP112 EXPH5 KIAA0232 AAK1 FGFR2 CDK11B PTPN21 CUL7 VIRMA CRK SON	2.17e-04	1014	82	13	int:YWHAB
Interaction	SCARNA5 interactions	VIRMA MOV10	2.43e-04	6	82	2	int:SCARNA5
Interaction	FOXO3B interactions	FOXO6 VIRMA	2.43e-04	6	82	2	int:FOXO3B
Interaction	YWHAZ interactions	JUP ERBB3 PTPN14 LATS2 CEP112 EXPH5 KIAA0232 AAK1 CDK11B PTPN21 CUL7 VIRMA CRK MOV10 DNMT1	2.50e-04	1319	82	15	int:YWHAZ
Interaction	GPS2 interactions	SETDB1 EYA4 KLF3 ANKRD12 NR1H4	3.05e-04	144	82	5	int:GPS2
Interaction	FBXO38 interactions	MORC4 VIRMA NCAPG2 MOV10 KNL1	3.15e-04	145	82	5	int:FBXO38
Interaction	CCDC88A interactions	EYA4 SEC24B AAK1 FGFR2 OCLN VIRMA	3.20e-04	226	82	6	int:CCDC88A
Interaction	URGCP interactions	EYA4 SEC24B AAK1	3.24e-04	33	82	3	int:URGCP
Interaction	NEDD4L interactions	ERBB3 SCN2A SYK OCLN VIRMA TMEM101 MOV10	3.27e-04	320	82	7	int:NEDD4L
Interaction	MAGI1 interactions	PTPN14 LATS2 OCLN VIRMA MOV10	3.35e-04	147	82	5	int:MAGI1
Interaction	JPH1 interactions	DPP4 ERBB3 STYK1 FGFR2 OCLN VIRMA	3.36e-04	228	82	6	int:JPH1
Interaction	NRG2 interactions	ERBB3 VIRMA	3.39e-04	7	82	2	int:NRG2
Interaction	H4C5 interactions	CUL7 VIRMA MOV10	3.55e-04	34	82	3	int:H4C5
Interaction	SRC interactions	DPP4 JUP ERBB3 LATS2 PIK3R3 SYK FGFR2 PTPN21 ITGB3 CRK	3.56e-04	664	82	10	int:SRC
Interaction	ZNF263 interactions	SETDB1 TCAF1 CUL7 ASCC3 DNMT1	3.57e-04	149	82	5	int:ZNF263
Interaction	UBXN6 interactions	CDK11B CUL7 ASCC3 MOV10 KNL1 ALPP PAPOLG	3.59e-04	325	82	7	int:UBXN6
Interaction	NOLC1 interactions	IKZF3 SYK CDK11B CUL7 VIRMA PXK MOV10	3.59e-04	325	82	7	int:NOLC1
Interaction	GOLGA3 interactions	DPP4 STRN3 FGFR2 CUL7 OCLN VIRMA	3.60e-04	231	82	6	int:GOLGA3
Interaction	PLEC interactions	JUP EYA4 SEC24B AAK1 CUL7 ITGB3 VIRMA CRK	3.61e-04	430	82	8	int:PLEC
Interaction	FYN interactions	STRN3 JUP PIK3R3 SYK ANKRD12 FGFR2 CRK SON	3.67e-04	431	82	8	int:FYN
Interaction	MAP3K3 interactions	STRN3 LATS2 CUL7 VIRMA	3.84e-04	84	82	4	int:MAP3K3
Interaction	NEDD9 interactions	PIK3R3 ITGB3 VIRMA CRK	4.01e-04	85	82	4	int:NEDD9
Interaction	KDM1A interactions	SETDB1 JUP IKZF3 SEC23IP KLF3 KDM1B ASCC3 MORC4 VIRMA CRK DNMT1 KNL1	4.07e-04	941	82	12	int:KDM1A
Interaction	ADGRL2 interactions	STYK1 CUL7 OCLN ADGRL2	4.20e-04	86	82	4	int:ADGRL2
Interaction	URM1 interactions	SEC23IP CDK11B MOV10	4.21e-04	36	82	3	int:URM1
Interaction	YPEL1 interactions	STRN3 STRN4	4.51e-04	8	82	2	int:YPEL1
Interaction	ORAI2 interactions	SETDB1 VIRMA	4.51e-04	8	82	2	int:ORAI2
Interaction	SNAI3 interactions	STRN3 VIRMA	4.51e-04	8	82	2	int:SNAI3
Interaction	LRRC37B interactions	LRRC37B VIRMA	4.51e-04	8	82	2	int:LRRC37B
Interaction	SNHG1 interactions	MOV10 DNMT1	4.51e-04	8	82	2	int:SNHG1
Interaction	STAT3 interactions	PIK3R3 SYK FGFR2 MORC4 BHLHE40 VIRMA MOV10 DNMT1	4.60e-04	446	82	8	int:STAT3
Interaction	TRIP11 interactions	DPP4 ERBB3 FGFR2 OCLN VIRMA	4.67e-04	158	82	5	int:TRIP11
Interaction	NBEA interactions	STYK1 STRN4 OCLN VIRMA	4.78e-04	89	82	4	int:NBEA
Interaction	MAN1A1 interactions	SEC24B SEC23IP OCLN VIRMA	4.78e-04	89	82	4	int:MAN1A1
Interaction	PKP4 interactions	LATS2 FGFR2 OCLN VIRMA MOV10	4.80e-04	159	82	5	int:PKP4
Interaction	NCK1 interactions	JUP ERBB3 PIK3R3 SYK ADGRL2 CRK	4.81e-04	244	82	6	int:NCK1
Interaction	PLA2G2A interactions	ERBB3 ITGB3 DNMT1	4.94e-04	38	82	3	int:PLA2G2A
Interaction	YWHAE interactions	JUP PTPN14 PAPOLA CEP112 EXPH5 KIAA0232 SEC23IP AAK1 CDK11B PTPN21 CUL7 VIRMA CRK DNMT1	5.05e-04	1256	82	14	int:YWHAE
Interaction	STYK1 interactions	JUP SEC24B STYK1 OCLN ADGRL2	5.08e-04	161	82	5	int:STYK1
Interaction	PPP1CA interactions	JUP IKZF3 SEC23IP AAK1 TXNDC16 CUL7 VIRMA CRK KNL1 SON	5.14e-04	696	82	10	int:PPP1CA
Interaction	RAPGEF1 interactions	VIRMA CRK MOV10	5.34e-04	39	82	3	int:RAPGEF1
Interaction	ZNF772 interactions	VIRMA MOV10	5.78e-04	9	82	2	int:ZNF772
Interaction	INSR interactions	DPP4 JUP PIK3R3 SEC24B OCLN VIRMA CRK	5.88e-04	353	82	7	int:INSR
Interaction	GARRE1 interactions	EYA4 CNOT6L SEC24B VIRMA MOV10	6.00e-04	167	82	5	int:GARRE1
Interaction	CPSF1 interactions	IKZF3 PAPOLA CUL7 VIRMA MOV10 TBP	6.07e-04	255	82	6	int:CPSF1
Interaction	ERBB3 interactions	JUP ERBB3 EYA4 PIK3R3 SYK FGFR2 CRK	6.08e-04	355	82	7	int:ERBB3
Interaction	AMOTL1 interactions	EYA4 LATS2 VIRMA MOV10	6.12e-04	95	82	4	int:AMOTL1
Interaction	MAGEA1 interactions	SELPLG SETDB1 STRN3 STRN4	6.12e-04	95	82	4	int:MAGEA1
Interaction	DSG2 interactions	JUP STYK1 FGFR2 CUL7 OCLN VIRMA	6.19e-04	256	82	6	int:DSG2
Interaction	CEP85 interactions	EYA4 LATS2 CNOT6L PTPN21 MOV10	6.33e-04	169	82	5	int:CEP85
Interaction	TRIP6 interactions	SETDB1 TCAF1 EYA4 PTPN14 PTPN21 MOV10 SON	6.39e-04	358	82	7	int:TRIP6
Interaction	AR interactions	JUP LATS2 EXPH5 PIK3R3 SYK MORC4 VIRMA NIPBL CRK KNL1 SON TBP	6.51e-04	992	82	12	int:AR
Interaction	APRT interactions	DPP4 JUP CUL7 VIRMA	6.62e-04	97	82	4	int:APRT
Interaction	DSN1 interactions	PIK3R3 TMEM101 MOV10 KNL1	6.62e-04	97	82	4	int:DSN1
Interaction	STRIP1 interactions	STRN3 STRN4 VIRMA MOV10	6.62e-04	97	82	4	int:STRIP1
GeneFamily	Zinc fingers CW-type	KDM1B MORC4	1.89e-04	7	55	2	96
GeneFamily	WD repeat domain containing\|Protein phosphatase 2 regulatory subunits	STRN3 STRN4	9.30e-04	15	55	2	696
GeneFamily	Protein tyrosine phosphatases, non-receptor type	PTPN14 PTPN21	1.35e-03	18	55	2	812
GeneFamily	Protein phosphatase catalytic subunits\|STRIPAK complex	STRN3 STRN4	1.67e-03	20	55	2	1371
GeneFamily	SH2 domain containing	PIK3R3 SYK CRK	3.60e-03	101	55	3	741
Coexpression	HALLMARK_UV_RESPONSE_DN	PIK3R3 PTPN21 ADGRL2 BHLHE40 ITGB3 NIPBL	6.15e-06	144	82	6	M5942
Coexpression	GSE40274_CTRL_VS_FOXP3_AND_HELIOS_TRANSDUCED_ACTIVATED_CD4_TCELL_UP	DPP4 IKZF3 CNOT6L SEC24B SYK PAPOLG	3.74e-05	198	82	6	M9119
Coexpression	GSE40277_GATA1_AND_SATB1_TRANSDUCED_VS_CTRL_CD4_TCELL_UP	ERBB3 IKZF3 LATS2 KLF3 VIRMA CRK	3.96e-05	200	82	6	M9175
Coexpression	GSE2770_TGFB_AND_IL4_VS_TGFB_AND_IL12_TREATED_ACT_CD4_TCELL_6H_DN	IKZF3 CEP112 SEC24B ZSWIM4 BHLHE40 SON	3.96e-05	200	82	6	M6102
Coexpression	DURAND_STROMA_S_UP	SEMA3F JUP EYA4 FGFR2 MORC4 ADGRL2 TCF7L1	4.38e-05	300	82	7	M2581
Coexpression	DURAND_STROMA_S_UP	SEMA3F JUP EYA4 FGFR2 MORC4 ADGRL2 TCF7L1	4.76e-05	304	82	7	MM1083
ToppCell	Control-B_intermediate-6\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	EYA4 ST3GAL5 SYK ADAM32 BHLHE40 PXK	1.36e-06	189	82	6	11cb9a16f1de8f60af2073ed7ea6d4f41c02f299
ToppCell	COVID-19_Mild-Neu_2\|World / 5 Neutrophil clusters in COVID-19 patients	ERBB3 TCAF1 AMER1 FGFR2 ITGB3	6.11e-06	140	82	5	b1429028c52f84127b894b93b55961badcd5246f
ToppCell	Control-B_intermediate-6\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	EYA4 ST3GAL5 SYK PLPP7 PXK	8.01e-06	148	82	5	662c057030effc9eb61216e81d3967e6983c244f
ToppCell	Leuk-UTI-Lymphocyte-T_NK-dnT\|Leuk-UTI / Disease, Lineage and Cell Type	AMER1 TENT4B PIK3R3 ZNF654 KNL1	8.27e-06	149	82	5	53f145cf7089d948d41aa3c443e983e011826836
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Lymphocytic-NK_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IKZF3 STYK1 CDH23 KNL1 GGT7	8.55e-06	150	82	5	973252f4de9a1194aea9f3cb0e1f113643f16c91
ToppCell	PND28-Immune-Immune_Myeloid-DC-cDC2-cDC2_prolif\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ST3GAL5 SEC24B BHLHE40 NCAPG2 DNMT1	1.66e-05	172	82	5	eba1568d4307e91c94fc616549057cbed8df5840
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	EYA4 SCN2A SYK TMEM101 PXK	1.90e-05	177	82	5	f35b04c3557ebbdeba37dec54c8f45880eafb422
ToppCell	Control-Epithelial-Basal\|World / Disease state, Lineage and Cell class	JUP EYA4 GPX2 FGFR2 TCF7L1	2.17e-05	182	82	5	759390dde9b18757f7675d13d44c89d0e32f8d93
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	EYA4 SYT3 SCN2A SYK ADGRL2	2.17e-05	182	82	5	f96095b81188b52db8fcfca4837129cfcd9bd7b7
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	IKZF3 ST3GAL5 GPX2 CDH23 BHLHE40	2.17e-05	182	82	5	678eadd57e7e830fc2bf9fd35616d3badce01705
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell-Papillary_Tip_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	IKZF3 ST3GAL5 GPX2 CDH23 BHLHE40	2.17e-05	182	82	5	8d1229fa5aa6e2e38f2ac6fe4f4dc89752fe9344
ToppCell	Control-Epithelial-Basal\|Control / Disease state, Lineage and Cell class	JUP EYA4 GPX2 FGFR2 TCF7L1	2.17e-05	182	82	5	caddd0a52f0234ea6a916186ffaf2454cdcd80ee
ToppCell	PCW_13-14-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	DPP4 ERBB3 ST3GAL5 EXPH5 SYK	2.41e-05	186	82	5	bb0bfe9a015151be08a6ffc5d82896d0556d76de
ToppCell	E12.5-Epithelial-alveolar_epithelial_cell-type_I_pneumocyte\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	DPP4 ERBB3 EXPH5 GPX2 OCLN	2.48e-05	187	82	5	baff4edc1bf64e3e03864a434fa47075ff7372fd
ToppCell	Smart-seq2-spleen_(Smart-seq2)-lymphocytic-innate_lymphocytic-mature_NK_T_cell\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SELPLG MGAM CNOT6L KLF3 BHLHE40	2.48e-05	187	82	5	6981b856187a2e689260ecb7d0a1193a374ee9b9
ToppCell	PCW_13-14-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ERBB3 ST3GAL5 EXPH5 SYK OCLN	2.54e-05	188	82	5	0d86044bc340e3efb90d0022dd299873639d831c
ToppCell	PCW_10-12-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ERBB3 ST3GAL5 EXPH5 FGFR2 OCLN	2.54e-05	188	82	5	beb2df2332a46cc81b10e8e29fc9829020111f03
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	EYA4 SCN2A SYK TMEM101 PXK	2.60e-05	189	82	5	a9864873b19ab3e60acf11f288fa7275badc2e42
ToppCell	PCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	DPP4 ERBB3 ST3GAL5 EXPH5 FGFR2	2.67e-05	190	82	5	625c08a0e5227efc46daa512fd579c3938ff76c7
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	EYA4 SCN2A SYK TMEM101 PXK	2.67e-05	190	82	5	b3bccf4dd95e986db3cee324a6737f5fcc22e8e5
ToppCell	COPD-Epithelial-Club\|COPD / Disease state, Lineage and Cell class	JUP ERBB3 EXPH5 FGFR2 OCLN	2.74e-05	191	82	5	c909cf5fa0e6519aa93a47d2c3fcd2ae2163cd8d
ToppCell	Control-Epithelial-Club\|Control / Disease state, Lineage and Cell class	JUP ERBB3 EXPH5 FGFR2 OCLN	2.81e-05	192	82	5	d84ed1ea4a03edaa18c804f75afb03bd7b1f0e16
ToppCell	Fetal_29-31_weeks-Epithelial\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ERBB3 ST3GAL5 EXPH5 FGFR2 OCLN	2.88e-05	193	82	5	a0ca3231992f14abcf1a6129573bace320e89d2a
ToppCell	COVID-19_Mild\|World / Disease condition and Cell class	TENT4B CNOT6L KLF3 ANKRD12 BHLHE40	2.88e-05	193	82	5	7256a5a491536c525b31ae96d47ab5c6303cb73a
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPP4 IKZF3 SYK KDM1B NIPBL	2.95e-05	194	82	5	11709704079f24a730476572dc2f01e9d2226e2c
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPP4 IKZF3 SYK KDM1B NIPBL	2.95e-05	194	82	5	3a1f95639d5f239f001bd67d4213e8938e7f299d
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4\|GI_small-bowel / Manually curated celltypes from each tissue	DPP4 AAK1 KLF3 ANKRD12 BHLHE40	2.95e-05	194	82	5	4547b57669be5d4f0de55175802ee04372288a6a
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-lymphocytic-T_lymphocytic-type_I_NK_T_cell\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	IKZF3 CNOT6L STYK1 AAK1 SON	3.02e-05	195	82	5	0a72b8446399807ace5b6c72f865bb40dbd9e92d
ToppCell	facs-Aorta-Heart-3m-Endothelial-aorta_endothelial_cell\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3F JUP COLGALT2 ADGRL2 ITGB3	3.02e-05	195	82	5	3969b8d5fcec8ef1831531a781f7bbcebab5a4ba
ToppCell	PCW_13-14-Epithelial-Epithelial_proliferating\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ERBB3 ST3GAL5 EXPH5 SYK OCLN	3.10e-05	196	82	5	7b17d47b7758d8ccf9dbefd097aeb553791a1eed
ToppCell	AT1-AT2_cells\|World / lung cells shred on cell class, cell subclass, sample id	JUP ERBB3 EXPH5 PTPN21 ALPP	3.25e-05	198	82	5	a5b3617ea2ed4bffba59edcf6284799c2b3bbb29
ToppCell	COVID-19-COVID-19_Mild-Myeloid-immature_Neutrophil\|COVID-19_Mild / Disease, condition lineage and cell class	MGAM ERBB3 FGFR2 NCAPG2 TCF7L1	3.33e-05	199	82	5	e222b90caf45904d8f763574e7b6aac13333df92
ToppCell	Biopsy_Other_PF-Epithelial-SCGB3A2+_SCGB1A1+\|Biopsy_Other_PF / Sample group, Lineage and Cell type	JUP ERBB3 UGT1A6 FGFR2 OCLN	3.33e-05	199	82	5	036244251d2dd39f8184b7095418c723c0524eff
ToppCell	mild-gd_T\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	IKZF3 CNOT6L AAK1 KLF3 BHLHE40	3.41e-05	200	82	5	109f673a4967ffa52270a0b4f818b3461288db44
ToppCell	COVID-19\|World / Disease, condition lineage and cell class	KLF3 ANKRD12 BHLHE40 NIPBL SON	3.41e-05	200	82	5	7dec470c379cd89f05a0f37c8628b21f136e52f0
ToppCell	PND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SELPLG STYK1 NCAPG2 PAPOLG	1.37e-04	142	82	4	c2a3cd9998fd9a8e6b2665347ca5c32511776488
ToppCell	pdx-Tumor_cells-T9\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	PTPN14 LATS2 PIK3R3 PAPOLG	1.45e-04	144	82	4	0b94d978262a826c9254145aa98c6c30240243f9
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	EYA4 SCN2A SYK TMEM101	1.53e-04	146	82	4	e887e9de895fd453faa703997ef372cc6410fc49
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DRC7 EYA4 SCN2A SYK	1.61e-04	148	82	4	18cfecd6ae20edb74f5d44ba759909df356acf3a
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_T/NK-CD4-positive,_alpha-beta_T_cell-CD4_T_cells-CD4_T_cells_L.1.1.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IKZF3 CNOT6L FOXO6 AAK1	1.70e-04	150	82	4	207fc230d7721149c7afc7970dd56817f52801d8
ToppCell	Lymphoid-Lymphoid-T_cells_(Cd4+_Tnaive-Tcm)\|Lymphoid / shred on cell class and cell subclass (v4)	SELPLG DPP4 TENT4B KLF3	1.83e-04	153	82	4	ffb8ac88513e83d3ba01574e60beb5476154372b
ToppCell	facs-MAT-Fat-3m-Lymphocytic-NK_cell\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELPLG IKZF3 STYK1 BHLHE40	1.88e-04	154	82	4	391d40ef902773ffe832a50a14d35d31c56d3723
ToppCell	10x5'-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8\|bone_marrow / Manually curated celltypes from each tissue	CNOT6L AAK1 ANKRD12 EZHIP	1.97e-04	156	82	4	1545169694f686d28648a68b552c2ae606599d66
ToppCell	severe_COVID-19-NK_CD56bright\|severe_COVID-19 / disease group, cell group and cell class (v2)	AMER1 LDOC1 OCLN BHLHE40	2.07e-04	158	82	4	c2e8d96fc29aa2388b92b4fd81d2726e1f7a053f
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	EYA4 SCN2A SYK TMEM101	2.07e-04	158	82	4	debebc8534a80e5500051f6fd352dc201585968d
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Pld5\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	DPP4 EXPH5 ADGRL2 BHLHE40	2.12e-04	159	82	4	a082e770fa757c4a1d3ed13d53f83297e36faf05
ToppCell	facs-SCAT-Fat-18m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELPLG IKZF3 STYK1 BHLHE40	2.12e-04	159	82	4	51bdbacb79227fbee38bb8680c58cb99878df0c7
ToppCell	facs-GAT-Fat-18m-Lymphocytic-NK_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELPLG IKZF3 STYK1 BHLHE40	2.12e-04	159	82	4	796e63f6052189106359a4e01eae3e466bf1d593
ToppCell	COVID-CD4-CD4_Treg\|COVID / Condition, Cell_class and T cell subcluster	STRN3 ACVR1C VIRMA GGT7	2.12e-04	159	82	4	037cd97c41eb2f91fd3f69bbb3ffdfd6c0158410
ToppCell	URO-Lymphocyte-T_NK-CD4_TEM\|URO / Disease, Lineage and Cell Type	DPP4 IKZF3 SCN2A AAK1	2.17e-04	160	82	4	e406f77b1c1a01d74f39ba65f99d5f8c7d75faf1
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Lymphocytic-T_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELPLG IKZF3 SYK CDH23	2.17e-04	160	82	4	94e4f5fc2156dd8163811c3b8b0781ea9b3f2e06
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c10-MKI67-GZMK\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	SELPLG DPP4 TXNDC16 KNL1	2.28e-04	162	82	4	af9999e5fcd28ff1f401d52fd220315752c40027
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_artery-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SEMA3F PTPN14 PIK3R3 BHLHE40	2.28e-04	162	82	4	25bb1b9709f960fdf90faff56e874f52a8f5d17e
ToppCell	facs-Marrow-Granulocytes-18m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IKZF3 STYK1 CDH23 PLPP7	2.33e-04	163	82	4	7a04192710f55acf5a4681d5f09942358fdb02ff
ToppCell	facs-BAT-Fat-18m-Lymphocytic-NK_cell\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELPLG IKZF3 STYK1 BHLHE40	2.39e-04	164	82	4	ab9c17f86b98e1a4d5db1bd3086edab1320ebda8
ToppCell	droplet-Lung-LUNG-30m-Lymphocytic-Natural_Killer\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELPLG IKZF3 STYK1 BHLHE40	2.39e-04	164	82	4	e9e5a1462d8ed60b2e5bf603c8c47eb85bce83d5
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SCN2A SYK TMEM101 PXK	2.44e-04	165	82	4	9bd332e5ede759a00a47728ea5558c215efdd77a
ToppCell	facs-Lung-nan-3m-Epithelial-type_I_pneumocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ERBB3 EXPH5 FGFR2 ADAM32	2.50e-04	166	82	4	11b0ae82b3068ef91715dbdd49fe8e9791b4a480
ToppCell	droplet-Bladder-BLADDER-1m-Hematologic-granulocyte-monocyte_progenitor\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELPLG DPP4 ST3GAL5 SYK	2.50e-04	166	82	4	8e5a262dc4f04c5fc75b9a7a907832a0d7877df0
ToppCell	droplet-Lung-LUNG-30m-Lymphocytic-NK_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELPLG IKZF3 STYK1 BHLHE40	2.50e-04	166	82	4	0b7503e27e26dcbf7f1b893c32ce0b21ce58bd4a
ToppCell	droplet-Bladder-nan-3m-Hematologic-granulocyte-monocyte_progenitor\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELPLG DPP4 ST3GAL5 SYK	2.50e-04	166	82	4	e01c720de6d4ca144c55378e023e718a64bf32f6
ToppCell	facs-Lung-nan-3m-Epithelial-Alveolar_Epithelial_Type_1\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ERBB3 EXPH5 FGFR2 ADAM32	2.50e-04	166	82	4	fcc1aec31ebd39432d4cb284dc8fadf34e3c566a
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	ERBB3 FGFR2 OCLN GGT7	2.50e-04	166	82	4	89e2b8453180983533faccb4275867861876d7ee
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Adenocarcinoma_Mixed_Subtype-7\|TCGA-Lung / Sample_Type by Project: Shred V9	DPP4 ERBB3 ST3GAL5 OCLN	2.67e-04	169	82	4	5f522a10b6ec24a353f53bec2f779a81cd5f9581
ToppCell	wk_08-11-Mesenchymal-Myofibro_&_SMC-Myofibro_2\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	SEMA3F EYA4 AMER1 CDK11B	2.74e-04	170	82	4	fefb07a7e308b620f946b9ff2b01e1796446fe38
ToppCell	367C-Myeloid-Dendritic-cDC_proliferating_2\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	MGAM PIK3R3 NCAPG2 KNL1	2.80e-04	171	82	4	0eea035fde32cc2a75a0d4227911edb5d54ed47e
ToppCell	facs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-1\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DPP4 MGAM SCN2A TCF7L1	2.99e-04	174	82	4	1d157f7a919c8246e83d8060d2a0017c6c781ef3
ToppCell	droplet-Marrow-BM-1m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGAM LATS2 BHLHE40 VIRMA	3.05e-04	175	82	4	c1c722db42da9b8a2a46e516ddb83d9be5e2e504
ToppCell	droplet-Lung-LUNG-30m-Myeloid-Ccr7+_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBPL2 DPP4 BHLHE40 PAPOLG	3.05e-04	175	82	4	91cb819a1786020713b7e64480de0545380daae9
ToppCell	droplet-Lung-30m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TBPL2 DPP4 BHLHE40 PAPOLG	3.19e-04	177	82	4	4672cc75225a4a23b298afa8ce439628262519db
ToppCell	E16.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SYK CDH23 PLPP7 ITGB3	3.19e-04	177	82	4	84591e28482ab62a5ef41e61043eb64912766356
ToppCell	E16.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet-Megakaryocyte/Platelet_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SYK CDH23 PLPP7 ITGB3	3.19e-04	177	82	4	4bc100062891d07cacd10ffba38966cc6302c92f
ToppCell	E16.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SYK CDH23 PLPP7 ITGB3	3.19e-04	177	82	4	9f3a2adb9cd4f0a059afc87b6e377a9702154bb1
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TCAF1 PTPN14 ST3GAL5 ACVR1C	3.19e-04	177	82	4	75cb2067a3f2d1b5a964890b02b604d1e79bd163
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ERBB3 PTPN14 FGFR2 OCLN	3.33e-04	179	82	4	cb38b54261a7af5ee3347e64c8aa880a77ed0763
ToppCell	367C-Lymphocytic-ILC-ILC-2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	LATS2 PIK3R3 SYK FAHD1	3.33e-04	179	82	4	5aa8465e943b6b666c7f8b1937fcc3764bfe91f6
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	EYA4 SCN2A AAK1 ADGRL2	3.33e-04	179	82	4	d3438fed0d85d5ed5afa8ff820c45143d77b6c0d
ToppCell	MS-Treg-naive_CD4\|MS / Condition, Cell_class and T cell subcluster	PTPN14 STRN4 CUL7 MORC4	3.40e-04	180	82	4	7ca083616926d98420fa11a6e5ebc981623f79ac
ToppCell	droplet-Liver-nan-3m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPP4 PIK3R3 ADGRL2 TCF7L1	3.47e-04	181	82	4	fcc94f04dae98b817ec06b282d2e887804d37ae5
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Adenocarcinoma_Mixed_Subtype\|TCGA-Lung / Sample_Type by Project: Shred V9	DPP4 ERBB3 ST3GAL5 OCLN	3.47e-04	181	82	4	c783c2ecca7ab8e07646fa92dc7d436d24939d03
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	EYA4 SCN2A SYK TCF7L1	3.47e-04	181	82	4	b7c85fbef3c06d5dc32a2a58f8d3dfabf1d79d9f
ToppCell	facs-Skin-Anagen-3m-Epithelial-Basal_IFE\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3F EXPH5 FGFR2 BHLHE40	3.54e-04	182	82	4	22d6f4790950508e8aa27e02a8133af5f53f13c8
ToppCell	IIH-Treg-proli_CD4\|IIH / Condition, Cell_class and T cell subcluster	FAM210A ACVR1C MORC4 CRK	3.54e-04	182	82	4	5c7d02da9ca2bca49db9832704b6894dfaa08a71
ToppCell	E12.5-Epithelial-epithelial_progenitor_cell-epithelial_progenitor_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	DPP4 ERBB3 GPX2 OCLN	3.54e-04	182	82	4	204530444e35d4977a7239ac176f477e9e5c29ab
ToppCell	Smart-seq2-blood_(Smart-seq2)-lymphocytic-T_lymphocytic-CD4-positive,_alpha-beta_memory_T_cell\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	IKZF3 KLF3 ANKRD12 SON	3.62e-04	183	82	4	4c566be2dbbac36936f065af57b524403aae9711
ToppCell	Mild/Remission-B_intermediate-6\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	ST3GAL5 SYK BHLHE40 KNL1	3.69e-04	184	82	4	3d4864605c812862cf8926e02370eea3b8ccf32f
ToppCell	COVID-19-kidney-FLT1+PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SEMA3F ADGRL2 BHLHE40 SPPL2C	3.77e-04	185	82	4	673308ca0514a4d3629d61fe91e9d8fb31b72166
ToppCell	3'-Pediatric_IBD-SmallIntestine-Hematopoietic-T_cells-Th1\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SELPLG DPP4 AAK1 BHLHE40	3.77e-04	185	82	4	326c8b6ea0e9140616d7b867db1385b980dc3678
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	EYA4 SCN2A SYK PXK	3.77e-04	185	82	4	3d73b3e0bceb192257e5cfbe64b7ccb379b6e22d
ToppCell	Smart-seq2-spleen_(Smart-seq2)-lymphocytic-innate_lymphocytic\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SELPLG MGAM CNOT6L BHLHE40	3.85e-04	186	82	4	fc0b488c201a32d829047b58460297df2818b45d
ToppCell	NS-critical-LOC-Epithelial-Basal\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SEMA3F PIK3R3 GPX2 MORC4	3.85e-04	186	82	4	c28f62524637c7eb9c43c9ec38fb12dfec6f5566
ToppCell	facs-Heart-LA-24m-Myeloid-macrophage\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPX2 STYK1 ACVR1C OCLN	3.85e-04	186	82	4	246503fd4e6ae24041c606b069eb5fb313e60f73
ToppCell	facs-Heart-LA-24m-Myeloid-macrophage\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPX2 STYK1 ACVR1C OCLN	3.85e-04	186	82	4	ef93ac469eb4f63db036f14b442c1503b8c6de38
ToppCell	Control-Epithelial-Club\|World / Disease state, Lineage and Cell class	JUP ERBB3 FGFR2 OCLN	3.85e-04	186	82	4	9798428691408e17ff2af2fe2d1b345f074d67e4
ToppCell	COPD-Epithelial-Club\|World / Disease state, Lineage and Cell class	JUP EXPH5 FGFR2 OCLN	3.85e-04	186	82	4	3006f4ab1eaf1eb34c10ca9f7c869603d2d25744
ToppCell	droplet-Bladder-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLF3 ANKRD12 NIPBL SON	3.92e-04	187	82	4	663991a8afe652e92363b64bcbd68c14d0307f0e
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Endothelial-endothelial_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3F PTPN14 COLGALT2 ADGRL2	3.92e-04	187	82	4	3548a9914c2b2f5d805798ce22ab26eab6d03897
ToppCell	E12.5-Epithelial\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	DPP4 ERBB3 GPX2 OCLN	3.92e-04	187	82	4	29ea5e14dac3321df76f6aa4f053068b49c4a4bf
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ERBB3 PTPN14 FGFR2 OCLN	3.92e-04	187	82	4	9aa411ae9b5a923378a5daebb8bb2fc2613f2510
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DPP4 ST3GAL5 FGFR2 OCLN	3.92e-04	187	82	4	5df9e1f5ca32217af255e76e6fb5afa346337811
Computational	Genes in the cancer module 180.	DPP4 JUP ERBB3 ST3GAL5 OCLN	1.79e-04	119	48	5	MODULE_180
Drug	Acyclovir [59277-89-3]; Down 200; 17.8uM; PC3; HG-U133A	SETDB1 SEC23IP AAK1 ANKRD12 NIPBL DNMT1 TBP	7.66e-06	199	82	7	1960_DN
Drug	acetonate	MGAM SCN2A TBP	1.25e-05	13	82	3	CID000011671
Drug	1,1,3-tribromopropane	TBPL2 TBP	1.28e-05	2	82	2	CID000134838
Drug	beta-naphthyl triphosphate	MGAM SCN2A	1.28e-05	2	82	2	CID000193862
Disease	prostate cancer (is_marker_for)	SETDB1 JUP ERBB3 FGFR2 DNMT1	6.76e-05	156	80	5	DOID:10283 (is_marker_for)
Disease	Malignant neoplasm of breast	ERBB3 PTPN14 SYT3 FAM210A GPX2 COLGALT2 FGFR2 OCLN NIPBL TCF7L1 DNMT1	1.49e-04	1074	80	11	C0006142
Disease	permanent dental caries	MGAM PAPOLG	1.51e-04	7	80	2	EFO_0600096
Disease	Head and Neck Carcinoma	ERBB3 FGFR2	3.22e-04	10	80	2	C3887461
Disease	Alzheimer disease, gastroesophageal reflux disease	SEMA3F ERBB3 EYA4 TXNDC16 ADGRL2	3.96e-04	228	80	5	EFO_0003948, MONDO_0004975
Disease	carcinoma (implicated_via_orthology)	JUP ERBB3 LATS2	7.10e-04	64	80	3	DOID:305 (implicated_via_orthology)
Disease	brain connectivity measurement	SEMA3F DPP4 STRN3 ERBB3 KLF3 MOV10	7.72e-04	400	80	6	EFO_0005210
Disease	hearing loss	EYA4 PIK3R3 CDH23	8.11e-04	67	80	3	EFO_0004238
Disease	Benign neoplasm of stomach	ERBB3 FGFR2	9.61e-04	17	80	2	C0153943
Disease	Neoplasm of uncertain or unknown behavior of stomach	ERBB3 FGFR2	9.61e-04	17	80	2	C0496905
Disease	Carcinoma in situ of stomach	ERBB3 FGFR2	9.61e-04	17	80	2	C0154060
Disease	dyslexia	SEMA3F PTPN21 ACVR1C ADGRL2	1.00e-03	162	80	4	EFO_0005424
Disease	age at menarche	SCN2A SEC23IP AAK1 ASCC3 ADGRL2 BSX GGT7	1.16e-03	594	80	7	EFO_0004703
Disease	lung non-small cell carcinoma (is_marker_for)	ERBB3 IKZF3 ITGB3 DNMT1	1.17e-03	169	80	4	DOID:3908 (is_marker_for)
Disease	total blood protein measurement	IKZF3 SYK FGFR2 ASCC3 TCF7L1 PXK	1.40e-03	449	80	6	EFO_0004536
Disease	Stomach Carcinoma	ERBB3 FGFR2	1.47e-03	21	80	2	C0699791
Disease	endometriosis (is_marker_for)	FGFR2 DNMT1	2.09e-03	25	80	2	DOID:289 (is_marker_for)
Disease	lymphocyte percentage of leukocytes	IKZF3 TENT4B PIK3R3 CDH23 KLF3 TCF7L1 CRK	2.19e-03	665	80	7	EFO_0007993
Disease	systemic scleroderma, systemic lupus erythematosus	IKZF3 PXK	2.26e-03	26	80	2	EFO_0000717, MONDO_0007915
Disease	testosterone measurement	AMER1 ST3GAL5 CEP112 UGT1A6 SEC23IP PTPN21 ADGRL2 ZNF654 NR1H4 KNL1	2.31e-03	1275	80	10	EFO_0004908
Disease	hearing impairment	EYA4 CDH23 DNMT1	2.43e-03	98	80	3	C1384666
Disease	Schizophrenia	SETDB1 ERBB3 FGFR2 PTPN21 BHLHE40 ITGB3 DNMT1 TBP	2.70e-03	883	80	8	C0036341

Protein segments in the cluster

Peptide	Gene	Start	Entry
SEMYPVPPITRALLY	ATP6V1FNB	86	A0A1B0GUX0
YMSTPPPVKEYLQDR	FAM210A	221	Q96ND0
PPRPSSLEELGYEYM	ERBB3	1211	P21860
YILMDPSPEYAPIFG	DNMT1	486	P26358
RYMLEPDPDKRPDIY	AAK1	291	Q2M2I8
YLIPPSATAYLPMLE	BHLHE40	326	O14503
LPYYDMVPSDPSIEE	ACVR1C	416	Q8NER5
PSYMSIYFDEPNPAR	CEP112	96	Q8N8E3
ASRVPLLDYGYPLMP	BSX	46	Q3C1V8
LYTSMPNLRDSPYPE	ADGRL2	1371	O95490
YMLLDPVRSYPGLAP	AMER1	436	Q5JTC6
SEPAVPDLFPLYLEM	ADAM32	176	Q8TC27
EYFRETPLPIDPSMF	CDK11B	721	P21127
TTPRPPVEYDSDFML	ANKRD12	1221	Q6UB98
APYYINLVEMTPPDS	CDH23	781	Q9H251
LPEPPALSVMYSYLH	EFCAB12	181	Q6NXP0
MIPVPYVEKYRPASA	CRK	181	P46108
RPMLSQPAYSFYPED	OCLN	36	Q16625
PPSDYVERVDSPMAY	OCLN	311	Q16625
YSPGIYELRRMPAET	NR1H4	91	Q96RI1
DGYRPSMLYIEDPLQ	TENT4B	351	Q8NDF8
PPGMEYSYDINRVPE	FGFR2	581	P21802
PYFAMPVREPERYPL	FAM166C	136	A6NJV1
PGIEPQRTDYYPEEM	KLF3	201	P57682
PYIEMDSPILGDYRA	LDOC1	106	O95751
PTALEEMPRPYVDYL	LATS2	201	Q9NRM7
LPMDTEVYESPYADP	SYK	341	P43405
PYMPYLESRDRGLSS	MGAM	2341	O43451
PESLRYALMPEFYAL	EZHIP	466	Q86X51
YALMPEFYALSPVPP	EZHIP	471	Q86X51
YMSITSFPRLPEDEP	GGT7	21	Q9UJ14
VEMYYEAFPPLSEKP	KIAA0232	171	Q92628
PMTELYAVPYVLPED	CUL7	466	Q14999
EALEALAPSSPLMYP	FOXO6	266	A8MYZ6
MEDYSPPPSLSEVAR	NIPBL	1156	Q6KC79
APSPMEIDPADKYVY	EXPH5	391	Q8NEV8
PPTPEDLMLSQYVYR	KNL1	1926	Q8NG31
TLPDDYLSMDTLYPG	LRRC37B	221	Q96QE4
YLSMDTLYPGSLPPE	LRRC37B	226	Q96QE4
YTERYMGLPTPEDNL	DPP4	666	P27487
AYAPEGSPILMPAYT	FAHD1	51	Q6P587
YRPMYSSDVPLDPLE	JUP	701	P14923
IPPSYRPTPDYETVM	PTPN21	441	Q16825
PSDRYHLMPIITPAY	PAPOLA	306	P51003
RMGTPDPEYPDDYSQ	ALPP	231	P05187
SDRYHLMPIITPAYP	PAPOLG	306	Q9BWT3
PYSTELIFYIEMDPP	PIK3R3	21	Q92569
QPYSLPTYDLGVMLP	EYA4	186	O95677
EFPEYSRDPTMYLAL	KDM1B	296	Q8NB78
TTLRPTLMPYPELYN	DRC7	131	Q8IY82
PVSPYMYISPPEALE	ITGB3	186	P05106
DKLPYPYDDPFSLMT	GPX2	121	P18283
IEMLPGYRDPYSSRP	COLGALT2	391	Q8IYK4
PMGNAEEPEIPYSYS	IKZF3	76	Q9UKT9
ASSDYMLRPPQPAVY	SEC24B	666	O95487
TPEPSYLDMDSYPEA	SYT3	156	Q9BQG1
YDFLPETEPPEMLRN	SELPLG	51	Q14242
NMPSPSVDPYDTYEP	STRN3	561	Q13033
PMPTAPRQDYIFYLE	SEMA3F	176	Q13275
PEIEDMYSSPYLRPS	TCAF1	511	Q9Y4C2
ELSMALGTYYPPPRL	MOV10	286	Q9HCE1
PSLDYSMPAPYRRVE	MORC4	586	Q8TE76
SMPAPYRRVEAPVAY	MORC4	591	Q8TE76
VPSYRPTPDYETVMR	PTPN14	436	Q15678
VRVAMYAPPEPIIDY	SPPL2C	171	Q8IUH8
RMTYPEGAPLSDLEY	ST3GAL5	241	Q9UNP4
DSPYTPPSDSQRMIY	WDR17	1226	Q8IZU2
YHPLDPVAYRLEPMI	SEC23IP	821	Q9Y6Y8
EPSYRAPMEKLFYLP	SETDB1	561	Q15047
KLYEEVRIPYSEPMP	ASCC3	436	Q8N3C0
VRIPYSEPMPLSFEE	ASCC3	441	Q8N3C0
LYSLLEDPYPMVRST	NCAPG2	381	Q86XI2
YDPPDPRRIYTIMSA	CNOT6L	11	Q96LI5
LYEMVTLGAPPYPEV	STYK1	316	Q6J9G0
PPLPAYDFLSMIDAA	TXNDC16	741	Q9P2K2
GYPFLMIPDLSSPYL	TCF7L1	121	Q9HCS4
PDIEMRAYPIEQYPC	UROC1	81	Q96N76
SSYEPELFPGLIYRM	TBP	281	P20226
PEMVSVPLEDLDPYY	SCN2A	71	Q99250
LPPSYLDERYLSMPK	ZNF654	1051	Q8IZM8
LLYEMTYGRPPDSVP	PXK	341	Q7Z7A4
PDLSMDPYDGYDPSV	STRN4	521	Q9NRL3
RYDFVLEYPRPVMPN	UGT1A6	256	P19224
ASVPPMTYDPYDREL	VIRMA	331	Q69YN4
LGHDPYRLTPDPYRM	SON	951	P18583
PRSPLFSPVVPYDMY	TBPL2	56	Q6SJ96
PYETSPSLLDYLTMD	PLPP7	171	Q8NBV4
RKPDIPVPYLYFDMG	TMEM101	46	Q96IK0
EREICMYSSLGYPPP	ZSWIM4	76	Q9H7M6