Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	polysaccharide binding	CLEC18C CLEC18A CLEC18B	2.54e-05	31	37	3	GO:0030247
GeneOntologyBiologicalProcess	hair follicle morphogenesis	FST KRT27 KRT25 KRT28	6.83e-07	40	36	4	GO:0031069
GeneOntologyBiologicalProcess	epidermis morphogenesis	FST KRT27 KRT25 KRT28	1.21e-06	46	36	4	GO:0048730
GeneOntologyBiologicalProcess	hair follicle development	FST KRT27 KRT25 KRT28	6.12e-05	123	36	4	GO:0001942
GeneOntologyBiologicalProcess	molting cycle process	FST KRT27 KRT25 KRT28	6.72e-05	126	36	4	GO:0022404
GeneOntologyBiologicalProcess	hair cycle process	FST KRT27 KRT25 KRT28	6.72e-05	126	36	4	GO:0022405
GeneOntologyBiologicalProcess	molting cycle	FST KRT27 KRT25 KRT28	1.32e-04	150	36	4	GO:0042303
GeneOntologyBiologicalProcess	hair cycle	FST KRT27 KRT25 KRT28	1.32e-04	150	36	4	GO:0042633
GeneOntologyBiologicalProcess	skin epidermis development	FST KRT27 KRT25 KRT28	1.95e-04	166	36	4	GO:0098773
GeneOntologyBiologicalProcess	intermediate filament organization	KRT27 KRT25 KRT28	3.02e-04	75	36	3	GO:0045109
GeneOntologyBiologicalProcess	BMP signaling pathway	BMPR2 TMEM53 SMPD3 FST	3.74e-04	197	36	4	GO:0030509
GeneOntologyBiologicalProcess	response to BMP	BMPR2 TMEM53 SMPD3 FST	5.21e-04	215	36	4	GO:0071772
GeneOntologyBiologicalProcess	cellular response to BMP stimulus	BMPR2 TMEM53 SMPD3 FST	5.21e-04	215	36	4	GO:0071773
GeneOntologyBiologicalProcess	intermediate filament cytoskeleton organization	KRT27 KRT25 KRT28	6.83e-04	99	36	3	GO:0045104
GeneOntologyBiologicalProcess	intermediate filament-based process	KRT27 KRT25 KRT28	7.03e-04	100	36	3	GO:0045103
HumanPheno	Hypoplasia of the ventral pons	VRK1 TSEN2	3.23e-05	6	8	2	HP:0006850
Domain	-	CLEC18C CLEC18A CLEC18B	2.70e-06	15	35	3	3.40.33.10
Domain	CAP	CLEC18C CLEC18A CLEC18B	2.70e-06	15	35	3	PF00188
Domain	CAP_domain	CLEC18C CLEC18A CLEC18B	2.70e-06	15	35	3	IPR014044
Domain	SCP	CLEC18C CLEC18A CLEC18B	2.70e-06	15	35	3	SM00198
Domain	Allrgn_V5/Tpx1	CLEC18C CLEC18A CLEC18B	2.70e-06	15	35	3	IPR001283
Domain	C-type_lectin_CS	CLEC18C CLEC18A CLEC18B	7.07e-05	43	35	3	IPR018378
Domain	Keratin_I	KRT27 KRT25 KRT28	7.57e-05	44	35	3	IPR002957
Domain	Filament	KRT27 KRT25 KRT28	3.16e-04	71	35	3	SM01391
Domain	IF	KRT27 KRT25 KRT28	3.29e-04	72	35	3	PS00226
Domain	Filament	KRT27 KRT25 KRT28	3.43e-04	73	35	3	PF00038
Domain	IF	KRT27 KRT25 KRT28	3.86e-04	76	35	3	IPR001664
Domain	C_TYPE_LECTIN_1	CLEC18C CLEC18A CLEC18B	4.49e-04	80	35	3	PS00615
Domain	Lectin_C	CLEC18C CLEC18A CLEC18B	5.18e-04	84	35	3	PF00059
Domain	CLECT	CLEC18C CLEC18A CLEC18B	5.18e-04	84	35	3	SM00034
Domain	C_TYPE_LECTIN_2	CLEC18C CLEC18A CLEC18B	5.36e-04	85	35	3	PS50041
Domain	C-type_lectin-like	CLEC18C CLEC18A CLEC18B	5.55e-04	86	35	3	IPR001304
Domain	-	CLEC18C CLEC18A CLEC18B	7.88e-04	97	35	3	3.10.100.10
Domain	C-type_lectin-like/link	CLEC18C CLEC18A CLEC18B	8.36e-04	99	35	3	IPR016186
Domain	TRYPSIN_HIS	PRSS55 TMPRSS9 TMPRSS11B	9.38e-04	103	35	3	IPR018114
Domain	TRYPSIN_SER	PRSS55 TMPRSS9 TMPRSS11B	1.02e-03	106	35	3	PS00135
Domain	TRYPSIN_HIS	PRSS55 TMPRSS9 TMPRSS11B	1.05e-03	107	35	3	PS00134
Domain	CTDL_fold	CLEC18C CLEC18A CLEC18B	1.05e-03	107	35	3	IPR016187
Domain	Peptidase_S1A	PRSS55 TMPRSS9 TMPRSS11B	1.23e-03	113	35	3	IPR001314
Domain	TRYPSIN_DOM	PRSS55 TMPRSS9 TMPRSS11B	1.29e-03	115	35	3	PS50240
Domain	Tryp_SPc	PRSS55 TMPRSS9 TMPRSS11B	1.35e-03	117	35	3	SM00020
Domain	Trypsin	PRSS55 TMPRSS9 TMPRSS11B	1.49e-03	121	35	3	PF00089
Domain	Trypsin_dom	PRSS55 TMPRSS9 TMPRSS11B	1.49e-03	121	35	3	IPR001254
Domain	Peptidase_S1_PA	PRSS55 TMPRSS9 TMPRSS11B	1.56e-03	123	35	3	IPR009003
Domain	EGF_3	CLEC18C CLEC18A CLEC18B	9.57e-03	235	35	3	PS50026
Domain	EGF	CLEC18C CLEC18A CLEC18B	9.57e-03	235	35	3	SM00181
Domain	EGF-like_dom	CLEC18C CLEC18A CLEC18B	1.12e-02	249	35	3	IPR000742
Domain	EGF_1	CLEC18C CLEC18A CLEC18B	1.19e-02	255	35	3	PS00022
Domain	TRYPSIN_SER	PRSS55 TMPRSS9	1.23e-02	90	35	2	IPR033116
Domain	EGF-like_CS	CLEC18C CLEC18A CLEC18B	1.27e-02	261	35	3	IPR013032
Domain	EGF_2	CLEC18C CLEC18A CLEC18B	1.32e-02	265	35	3	PS01186
Pubmed	The C-type lectin-like domain superfamily.	CLEC18C CLEC18A CLEC18B	1.11e-09	3	37	3	16336259
Pubmed	Endosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection.	CLEC18C CLEC18A CLEC18B	1.11e-09	3	37	3	33603190
Pubmed	Human CLEC18 Gene Cluster Contains C-type Lectins with Differential Glycan-binding Specificity.	CLEC18C CLEC18A CLEC18B	1.11e-09	3	37	3	26170455
Pubmed	Mutations in the helix termination motif of mouse type I IRS keratin genes impair the assembly of keratin intermediate filament.	KRT27 KRT25 KRT28	4.43e-09	4	37	3	17920809
Pubmed	The mannose receptor mediates uptake of soluble but not of cell-associated antigen for cross-presentation.	CLEC18C CLEC18A CLEC18B	4.43e-09	4	37	3	16709836
Pubmed	The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain.	KRT27 KRT25 KRT28	2.42e-07	12	37	3	15617563
Pubmed	K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) represent the type I inner root sheath keratins of the human hair follicle.	KRT27 KRT25	3.30e-06	3	37	2	16874310
Pubmed	Strength training with blood flow restriction diminishes myostatin gene expression.	GPRASP1 FST	6.60e-06	4	37	2	21900845
Pubmed	The structure of the follistatin:activin complex reveals antagonism of both type I and type II receptor binding.	BMPR2 FST	6.60e-06	4	37	2	16198295
Pubmed	Comparison of the gene expression profiles from normal and Fgfrl1 deficient mouse kidneys reveals downstream targets of Fgfrl1 signaling.	CLEC18C CLEC18A CLEC18B	8.40e-06	37	37	3	22432025
Pubmed	FOXL2 and BMP2 act cooperatively to regulate follistatin gene expression during ovarian development.	BMPR2 FST	1.65e-05	6	37	2	21084449
Pubmed	Bmp signaling is required for development of primary lens fiber cells.	BMPR2 FST	3.07e-05	8	37	2	12117821
Pubmed	New consensus nomenclature for mammalian keratins.	KRT27 KRT25 KRT28	4.21e-05	63	37	3	16831889
Pubmed	Regulation of GDF-11 and myostatin activity by GASP-1 and GASP-2.	GPRASP1 FST	1.15e-04	15	37	2	24019467
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	ZNF140 STIP1 HERC3 PNMA8B	5.75e-04	361	37	4	26167880
Pubmed	Spatiotemporal single-cell regulatory atlas reveals neural crest lineage diversification and cellular function during tooth morphogenesis.	SMPD3 FST	7.16e-04	37	37	2	35974052
Pubmed	Accumulation of NCOA1 dependent on HERC3 deficiency transactivates matrix metallopeptidases and promotes extracellular matrix degradation in intervertebral disc degeneration.	HERC3 NRF1	9.67e-04	43	37	2	36878279
Cytoband	17q21.2	KRT27 KRT25 KRT28	2.54e-05	70	37	3	17q21.2
Cytoband	16q22.1	CLEC18C CLEC18A SMPD3	9.80e-05	110	37	3	16q22.1
Cytoband	Ensembl 112 genes in cytogenetic band chr16q22	CLEC18C CLEC18A SMPD3	4.38e-04	183	37	3	chr16q22
Cytoband	19p13.3	TMPRSS9 MPND ZNF556	9.27e-04	237	37	3	19p13.3
Cytoband	Ensembl 112 genes in cytogenetic band chr17q21	KRT27 KRT25 KRT28	6.51e-03	473	37	3	chr17q21
Cytoband	Ensembl 112 genes in cytogenetic band chr16p12	GGA2 IL21R	8.53e-03	172	37	2	chr16p12
GeneFamily	Keratins, type I	KRT27 KRT25 KRT28	9.49e-06	28	27	3	608
GeneFamily	C-type lectin domain family	CLEC18C CLEC18A CLEC18B	4.61e-05	47	27	3	494
GeneFamily	Proteases, serine	PRSS55 TMPRSS9 TMPRSS11B	1.11e-04	63	27	3	738
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th-Inhibitory_Neuron.Th-Slc17a6-Lpl_(VTA_(ventral_VTA))-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	FST KRT25 TMPRSS11B	1.17e-05	53	37	3	605cd3214c1c17a11b69ca65b44c4a3a322f3fbb
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th-Inhibitory_Neuron.Th-Slc17a6-Lpl_(VTA_(ventral_VTA))\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	FST KRT25 TMPRSS11B	1.17e-05	53	37	3	e7f69a8b4dab2d63da84b7aaa7e192c8e19a06ad
ToppCell	droplet-Marrow-BM-30m-Lymphocytic-naive_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM3C GGA2 TMEM53 IL21R	1.54e-05	182	37	4	8b16a13d8606d21a7a9ce1175237e9b4cf832ee0
Disease	Congenital pontocerebellar hypoplasia	VRK1 TSEN2	9.39e-05	13	33	2	C0266468
Disease	Pontoneocerebellar hypoplasia	VRK1 TSEN2	1.44e-04	16	33	2	cv:C1261175
Disease	pulmonary hypertension (implicated_via_orthology)	BMPR2 SMPD3	1.67e-03	54	33	2	DOID:6432 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
KKAYSFAMGCWPKNG	ERI3	276	O43414
CPWGKKAFSGYLGTD	ESD	181	P10768
GKKSGKKAGDWYGPA	ATG4C	221	Q96DT6
GLVAKACGCPLYWKG	PPP2R3B	166	Q9Y5P8
NWVFCGGKGIKTKSP	FAM3C	181	Q92520
RKIKGWYEKYGPGSC	KRT28	116	Q7Z3Y7
KCPSPVKGYWAAHSG	HERC3	336	Q15034
STGRGKPGWGKESCK	NRF1	216	Q16656
IKGWYEKFGPGSCRG	KRT27	116	Q7Z3Y8
IKGWYEKFGPGSCRG	KRT25	111	Q7Z3Z0
SAWYGKCVKGKGSLP	LAS1L	21	Q9Y4W2
PKYLGSWATGKVKGR	GGA2	116	Q9UJY4
TWKGPVCGLDGKTYR	FST	126	P19883
NPAKKSGCGWASVKY	MPND	136	Q8N594
SGCGWASVKYKGQKL	MPND	141	Q8N594
LLSEWKGTGPGKSFC	SMPD3	111	Q9NY59
SKGSTCYGLWEKSKG	BMPR2	61	Q13873
WFGYCKKLLPVGKGK	DENND2C	571	Q68D51
YKGCSGDFKKWVGAP	IL21R	281	Q9HBE5
KEPCMYPAGGGSWKS	GPRASP1	681	Q5JY77
SKGWVPKVGLKYGTD	TSEN2	351	Q8NCE0
HYLSPSGCTFWGKKP	RNF19B	326	Q6ZMZ0
GCKTVDLKPDWGKGY	STIP1	61	P31948
KPTKSITCLWGGLLY	TCAF1	601	Q9Y4C2
AWEGGKYKYPKGKLG	PNMA8B	471	Q9ULN7
NKPCAVVQYKSWKGG	POLH	31	Q9Y253
NGKTIVPYKKGAWCS	CLEC18A	191	A5D8T8
NGKTIIPYKKGAWCS	CLEC18B	191	Q6UXF7
NGKTIVPYKKGAWCS	CLEC18C	191	Q8NCF0
AWGKCSLPKFTVPKG	ARHGAP40	201	Q5TG30
SWGDGCGKKNKPGVY	TMPRSS11B	386	Q86T26
LGWGGCKDKNLAKYS	TMEM53	41	Q6P2H8
KCGKCGKAFGWPSSL	ZNF556	316	Q9HAH1
PPSKKCLISGWGYLK	TMPRSS9	321	Q7Z410
PKYWGSGLHDKNGKS	VRK1	111	Q99986
SWGKSCGEKNTPGIY	PRSS55	271	Q6UWB4
GPVYSSFKGGWKCKD	ZNF140	111	P52738
CRGSGKNKVGPWGDY	POTEH	146	Q6S545