Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	immune receptor activity	FPR2 C5AR2 IL20RB IL22RA1 IFNAR2 CCR8 CMKLR1	3.21e-05	165	108	7	GO:0140375
GeneOntologyMolecularFunction	complement receptor activity	FPR2 C5AR2 CMKLR1	5.36e-05	14	108	3	GO:0004875
GeneOntologyMolecularFunction	interleukin-20 binding	IL20RB IL22RA1	8.66e-05	3	108	2	GO:0042015
GeneOntologyMolecularFunction	interleukin-22 receptor activity	IL22RA1 IFNAR2	8.66e-05	3	108	2	GO:0042018
GeneOntologyMolecularFunction	cytokine receptor activity	IL20RB IL22RA1 IFNAR2 CCR8 CMKLR1	1.83e-04	97	108	5	GO:0004896
GeneOntologyMolecularFunction	interferon receptor activity	IL22RA1 IFNAR2	2.87e-04	5	108	2	GO:0004904
GeneOntologyMolecularFunction	cell adhesion molecule binding	FLNA PUF60 ITGA5 ITGAD FAP FASN PTPRD TENM3 PTPRM DLG1 MPP7	4.01e-04	599	108	11	GO:0050839
GeneOntologyCellularComponent	MPP7-DLG1-LIN7 complex	DLG1 MPP7	2.77e-04	5	111	2	GO:0097025
GeneOntologyCellularComponent	cell projection membrane	PSG1 CDHR1 ITGA5 ADCY3 FAP BMX DLG1 TRPV4 USH2A	4.90e-04	431	111	9	GO:0031253
GeneOntologyCellularComponent	stereocilium	TMC1 LOXHD1 PCDH15 USH2A	4.99e-04	69	111	4	GO:0032420
GeneOntologyCellularComponent	symbiont cell surface	C4A C4B	7.66e-04	8	111	2	GO:0106139
GeneOntologyCellularComponent	stereocilium bundle	TMC1 LOXHD1 PCDH15 USH2A	8.33e-04	79	111	4	GO:0032421
GeneOntologyCellularComponent	adherens junction	PSG1 PTPRM MPP4 DLG1 TRPV4 MPP7	9.48e-04	212	111	6	GO:0005912
GeneOntologyCellularComponent	other organism part	C4A C4B	9.82e-04	9	111	2	GO:0044217
Domain	MacrogloblnA2_thiol-ester-bond	CPAMD8 C4A C4B	9.47e-06	8	105	3	IPR019565
Domain	Thiol-ester_cl	CPAMD8 C4A C4B	9.47e-06	8	105	3	PF10569
Domain	MacrogloblnA2_CS	CPAMD8 C4A C4B	9.47e-06	8	105	3	IPR019742
Domain	Interfer-bind	IL20RB IL22RA1 IFNAR2	2.01e-05	10	105	3	PF09294
Domain	A2M	CPAMD8 C4A C4B	2.01e-05	10	105	3	PF00207
Domain	A2M_N_2	CPAMD8 C4A C4B	2.01e-05	10	105	3	IPR011625
Domain	A2M_comp	CPAMD8 C4A C4B	2.01e-05	10	105	3	IPR011626
Domain	A2M_recep	CPAMD8 C4A C4B	2.01e-05	10	105	3	PF07677
Domain	A2M_comp	CPAMD8 C4A C4B	2.01e-05	10	105	3	PF07678
Domain	A2M_N	CPAMD8 C4A C4B	2.01e-05	10	105	3	PF01835
Domain	A2M_N	CPAMD8 C4A C4B	2.01e-05	10	105	3	IPR002890
Domain	A-macroglobulin_rcpt-bd	CPAMD8 C4A C4B	2.01e-05	10	105	3	IPR009048
Domain	ALPHA_2_MACROGLOBULIN	CPAMD8 C4A C4B	2.01e-05	10	105	3	PS00477
Domain	A2M_N_2	CPAMD8 C4A C4B	2.01e-05	10	105	3	PF07703
Domain	Interferon/interleukin_rcp_dom	IL20RB IL22RA1 IFNAR2	2.01e-05	10	105	3	IPR015373
Domain	Macroglobln_a2	CPAMD8 C4A C4B	2.01e-05	10	105	3	IPR001599
Domain	FN3_dom	COL20A1 IL20RB IL22RA1 IFNAR2 PTPRD PTPRM TRIM36 USH2A	2.37e-05	209	105	8	IPR003961
Domain	KELK	CDC42BPA CDC42BPB	3.13e-05	2	105	2	IPR031597
Domain	KELK	CDC42BPA CDC42BPB	3.13e-05	2	105	2	PF15796
Domain	Tissue_fac	IL20RB IL22RA1 IFNAR2	3.66e-05	12	105	3	PF01108
Domain	Tissue_factor	IL20RB IL22RA1 IFNAR2	3.66e-05	12	105	3	IPR001187
Domain	L27	MPP4 DLG1 MPP7	4.74e-05	13	105	3	SM00569
Domain	L27	MPP4 DLG1 MPP7	4.74e-05	13	105	3	PS51022
Domain	L27_dom	MPP4 DLG1 MPP7	4.74e-05	13	105	3	IPR004172
Domain	Guanylate_kinase_CS	MPP4 DLG1 MPP7	9.17e-05	16	105	3	IPR020590
Domain	FN3	COL20A1 IL20RB IL22RA1 PTPRD PTPRM TRIM36 USH2A	1.32e-04	199	105	7	PS50853
Domain	LH2	LOXHD1 ALOXE3 ALOX12B	1.32e-04	18	105	3	SM00308
Domain	Terpenoid_cyclase/PrenylTrfase	CPAMD8 C4A C4B	1.32e-04	18	105	3	IPR008930
Domain	Myotonic_dystrophy_kinase_coil	CDC42BPA CDC42BPB	1.86e-04	4	105	2	IPR014930
Domain	Myotonic_dystrophy_kinase_coil	CDC42BPA CDC42BPB	1.86e-04	4	105	2	PD011252
Domain	DMPK_coil	CDC42BPA CDC42BPB	1.86e-04	4	105	2	PF08826
Domain	-	LOXHD1 ALOXE3 ALOX12B	2.13e-04	21	105	3	2.60.60.20
Domain	PLAT	LOXHD1 ALOXE3 ALOX12B	2.13e-04	21	105	3	PF01477
Domain	PLAT/LH2_dom	LOXHD1 ALOXE3 ALOX12B	2.13e-04	21	105	3	IPR001024
Domain	PLAT	LOXHD1 ALOXE3 ALOX12B	2.13e-04	21	105	3	PS50095
Domain	GUANYLATE_KINASE_2	MPP4 DLG1 MPP7	2.82e-04	23	105	3	PS50052
Domain	GUANYLATE_KINASE_1	MPP4 DLG1 MPP7	2.82e-04	23	105	3	PS00856
Domain	fn3	COL20A1 IL20RB PTPRD PTPRM TRIM36 USH2A	3.08e-04	162	105	6	PF00041
Domain	Anaphylatoxin_comp_syst	C4A C4B	3.10e-04	5	105	2	IPR018081
Domain	Anaphylatoxn_comp_syst_dom	C4A C4B	3.10e-04	5	105	2	IPR001840
Domain	Guanylate_kin	MPP4 DLG1 MPP7	4.09e-04	26	105	3	PF00625
Domain	GK/Ca_channel_bsu	MPP4 DLG1 MPP7	4.09e-04	26	105	3	IPR008145
Domain	Guanylate_kin-like_dom	MPP4 DLG1 MPP7	4.09e-04	26	105	3	IPR008144
Domain	GuKc	MPP4 DLG1 MPP7	4.09e-04	26	105	3	SM00072
Domain	LipOase_mml	ALOXE3 ALOX12B	4.63e-04	6	105	2	IPR001885
Domain	LIPOXYGENASE_1	ALOXE3 ALOX12B	4.63e-04	6	105	2	PS00711
Domain	LipOase_C	ALOXE3 ALOX12B	4.63e-04	6	105	2	IPR013819
Domain	LIPOXYGENASE_2	ALOXE3 ALOX12B	4.63e-04	6	105	2	PS00081
Domain	LipOase_Fe_BS	ALOXE3 ALOX12B	4.63e-04	6	105	2	IPR020833
Domain	LipOase_CS	ALOXE3 ALOX12B	4.63e-04	6	105	2	IPR020834
Domain	Lipoxygenase	ALOXE3 ALOX12B	4.63e-04	6	105	2	PF00305
Domain	LIPOXYGENASE_3	ALOXE3 ALOX12B	4.63e-04	6	105	2	PS51393
Domain	LipOase	ALOXE3 ALOX12B	4.63e-04	6	105	2	IPR000907
Domain	FN3	COL20A1 IL20RB PTPRD PTPRM TRIM36 USH2A	6.23e-04	185	105	6	SM00060
Domain	ANATO	C4A C4B	6.45e-04	7	105	2	SM00104
Domain	ANAPHYLATOXIN_2	C4A C4B	6.45e-04	7	105	2	PS01178
Domain	ANAPHYLATOXIN_1	C4A C4B	6.45e-04	7	105	2	PS01177
Domain	ANATO	C4A C4B	6.45e-04	7	105	2	PF01821
Domain	Anaphylatoxin/fibulin	C4A C4B	6.45e-04	7	105	2	IPR000020
Domain	A2M_N_2	CPAMD8 C4A	8.57e-04	8	105	2	SM01359
Domain	-	CPAMD8 C4A	8.57e-04	8	105	2	2.60.40.690
Domain	A2M_recep	CPAMD8 C4A	8.57e-04	8	105	2	SM01361
Domain	A2M	CPAMD8 C4A	8.57e-04	8	105	2	SM01360
Domain	L27_C	MPP4 MPP7	1.37e-03	10	105	2	IPR014775
Domain	-	RBM10 RBM5	1.37e-03	10	105	2	4.10.1060.10
Domain	L27	MPP4 MPP7	1.37e-03	10	105	2	PF02828
Domain	Formyl_rcpt-rel	FPR2 C5AR2	1.37e-03	10	105	2	IPR000826
Domain	SH3_2	MPP4 ITSN2 DLG1 MPP7	1.41e-03	86	105	4	PF07653
Domain	SH3_2	MPP4 ITSN2 DLG1 MPP7	1.41e-03	86	105	4	IPR011511
Domain	ConA-like_dom	COL20A1 RYR1 PTPRM COL21A1 TRIM36 USH2A	1.49e-03	219	105	6	IPR013320
Domain	BAH	TNRC18 BAHCC1	1.67e-03	11	105	2	PS51038
Domain	BAH_dom	TNRC18 BAHCC1	1.67e-03	11	105	2	IPR001025
Domain	BAH	TNRC18 BAHCC1	1.67e-03	11	105	2	SM00439
Domain	Integrin_alpha	ITGA5 ITGAD	1.67e-03	11	105	2	PF00357
Domain	BAH	TNRC18 BAHCC1	1.67e-03	11	105	2	PF01426
Domain	-	CPAMD8 C4A	1.99e-03	12	105	2	1.50.10.20
Domain	PP2Ac	PPP2CA PPP2CB	2.35e-03	13	105	2	SM00156
Domain	Ser/Thr-sp_prot-phosphatase	PPP2CA PPP2CB	2.35e-03	13	105	2	IPR006186
Domain	SER_THR_PHOSPHATASE	PPP2CA PPP2CB	2.35e-03	13	105	2	PS00125
Domain	Dynein_heavy_chain_D4_dom	DNAH12 DNAH8	2.73e-03	14	105	2	IPR024317
Domain	Dynein_heavy_dom-2	DNAH12 DNAH8	2.73e-03	14	105	2	IPR013602
Domain	DHC_N2	DNAH12 DNAH8	2.73e-03	14	105	2	PF08393
Domain	ATPase_dyneun-rel_AAA	DNAH12 DNAH8	2.73e-03	14	105	2	IPR011704
Domain	AAA_8	DNAH12 DNAH8	2.73e-03	14	105	2	PF12780
Domain	CNH	CDC42BPA CDC42BPB	2.73e-03	14	105	2	SM00036
Domain	AAA_5	DNAH12 DNAH8	2.73e-03	14	105	2	PF07728
Domain	DHC_fam	DNAH12 DNAH8	3.13e-03	15	105	2	IPR026983
Domain	Dynein_heavy	DNAH12 DNAH8	3.13e-03	15	105	2	PF03028
Domain	CNH	CDC42BPA CDC42BPB	3.13e-03	15	105	2	PF00780
Domain	Dynein_heavy_dom	DNAH12 DNAH8	3.13e-03	15	105	2	IPR004273
Domain	CNH	CDC42BPA CDC42BPB	3.13e-03	15	105	2	PS50219
Domain	CNH_dom	CDC42BPA CDC42BPB	3.13e-03	15	105	2	IPR001180
Domain	Integrin_alpha_C_CS	ITGA5 ITGAD	3.57e-03	16	105	2	IPR018184
Domain	PBD	CDC42BPA CDC42BPB	3.57e-03	16	105	2	SM00285
Domain	VWA	COL20A1 ITGAD COL21A1	3.86e-03	56	105	3	PF00092
Domain	CarboxyPept-like_regulatory	TENM3 AEBP1	4.03e-03	17	105	2	IPR008969
Domain	C345C	C4A C4B	4.03e-03	17	105	2	SM00643
Domain	-	FLNA PSG1 COL20A1 IL20RB IL22RA1 IFNAR2 PTPRD PTPRM TRIM36 USH2A	4.14e-03	663	105	10	2.60.40.10
Domain	Laminin_G	COL20A1 COL21A1 USH2A	4.26e-03	58	105	3	IPR001791
Domain	Integrin_alpha-2	ITGA5 ITGAD	4.52e-03	18	105	2	IPR013649
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FLNA FRAS1 CDC42BPA PUF60 REV3L ITGA5 CDC42BPB RYR1 PPP2CB FASN TNRC18 SBF2 ARC SPEN BCL2L13 BAHCC1	5.28e-07	1105	112	16	35748872
Pubmed	A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.	ISYNA1 RBM10 GDAP2 VPS33A BAG4 SBF2 RBM5 ZFR	9.10e-07	232	112	8	25515538
Pubmed	The role of complement in cryoglobulin-induced immune complex glomerulonephritis.	VPS33A C4A C4B	1.80e-06	8	112	3	16272350
Pubmed	Complement Inhibitor CRIg/FH Ameliorates Renal Ischemia Reperfusion Injury via Activation of PI3K/AKT Signaling.	C5AR2 C4A C4B	3.84e-06	10	112	3	30429287
Pubmed	Autosomal Recessive Congenital Ichthyosis	LIPN ALOXE3 ALOX12B	9.08e-06	13	112	3	20301593
Pubmed	Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.	C4A C4B	1.03e-05	2	112	2	22737222
Pubmed	Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.	C4A C4B	1.03e-05	2	112	2	16565498
Pubmed	Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.	C4A C4B	1.03e-05	2	112	2	15998580
Pubmed	Behavioral changes in FPR2/ALX and Chemr23 receptor knockout mice are exacerbated by prenatal alcohol exposure.	FPR2 CMKLR1	1.03e-05	2	112	2	37483341
Pubmed	High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.	C4A C4B	1.03e-05	2	112	2	19062096
Pubmed	Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A.	PPP2CA PPP2CB	1.03e-05	2	112	2	2555176
Pubmed	Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.	C4A C4B	1.03e-05	2	112	2	19933335
Pubmed	Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.	C4A C4B	1.03e-05	2	112	2	2459207
Pubmed	Antigen-induced B cell apoptosis is independent of complement C4.	C4A C4B	1.03e-05	2	112	2	17645767
Pubmed	Anti-DNA autoreactivity in C4-deficient mice.	C4A C4B	1.03e-05	2	112	2	12207352
Pubmed	The Mef2 transcription network is disrupted in myotonic dystrophy heart tissue, dramatically altering miRNA and mRNA expression.	A1CF MEF2C	1.03e-05	2	112	2	24412363
Pubmed	Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.	C4A C4B	1.03e-05	2	112	2	27758680
Pubmed	Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.	C4A C4B	1.03e-05	2	112	2	22387014
Pubmed	Partial USH2A deletions contribute to Usher syndrome in Denmark.	PCDH15 USH2A	1.03e-05	2	112	2	25804404
Pubmed	Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.	C4A C4B	1.03e-05	2	112	2	23749435
Pubmed	Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.	C4A C4B	1.03e-05	2	112	2	23918728
Pubmed	Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.	C4A C4B	1.03e-05	2	112	2	3037333
Pubmed	Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.	C4A C4B	1.03e-05	2	112	2	11726230
Pubmed	Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.	C4A C4B	1.03e-05	2	112	2	4216347
Pubmed	Cloning and chromosomal localization of human Cdc42-binding protein kinase beta.	CDC42BPA CDC42BPB	1.03e-05	2	112	2	10198171
Pubmed	Sequence determination of the thiolester site of the fourth component of human complement.	C4A C4B	1.03e-05	2	112	2	6950384
Pubmed	Regulation of spindle formation by active mitogen-activated protein kinase and protein phosphatase 2A during mouse oocyte meiosis.	PPP2CA PPP2CB	1.03e-05	2	112	2	11751260
Pubmed	Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.	C4A C4B	1.03e-05	2	112	2	8660986
Pubmed	Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.	C4A C4B	1.03e-05	2	112	2	8428773
Pubmed	Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.	C4A C4B	1.03e-05	2	112	2	24638111
Pubmed	Transcriptional repression of C4 complement by hepatitis C virus proteins.	C4A C4B	1.03e-05	2	112	2	21345967
Pubmed	Autoregulation of RBM10 and cross-regulation of RBM10/RBM5 via alternative splicing-coupled nonsense-mediated decay.	RBM10 RBM5	1.03e-05	2	112	2	28586478
Pubmed	Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.	C4A C4B	1.03e-05	2	112	2	2572548
Pubmed	The complement component C4 of mammals.	C4A C4B	1.03e-05	2	112	2	2302180
Pubmed	Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.	C4A C4B	1.03e-05	2	112	2	22151770
Pubmed	C4d-positive chronic rejection: a frequent entity with a poor outcome.	C4A C4B	1.03e-05	2	112	2	18091514
Pubmed	Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.	C4A C4B	1.03e-05	2	112	2	29080553
Pubmed	Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.	C4A C4B	1.03e-05	2	112	2	6589636
Pubmed	C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.	C4A C4B	1.03e-05	2	112	2	25339671
Pubmed	A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.	C4A C4B	1.03e-05	2	112	2	17728371
Pubmed	Structure and organization of the C4 genes.	C4A C4B	1.03e-05	2	112	2	6149580
Pubmed	Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.	C4A C4B	1.03e-05	2	112	2	6149581
Pubmed	Lipoxygenase-3 (ALOXE3) and 12(R)-lipoxygenase (ALOX12B) are mutated in non-bullous congenital ichthyosiform erythroderma (NCIE) linked to chromosome 17p13.1.	ALOXE3 ALOX12B	1.03e-05	2	112	2	11773004
Pubmed	The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.	C4A C4B	1.03e-05	2	112	2	12115608
Pubmed	Biochemistry and biology of anaphylatoxins.	C4A C4B	1.03e-05	2	112	2	3542363
Pubmed	C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.	C4A C4B	1.03e-05	2	112	2	2387317
Pubmed	Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.	C4A C4B	1.03e-05	2	112	2	16908004
Pubmed	Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.	C4A C4B	1.03e-05	2	112	2	7365238
Pubmed	Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.	C4A C4B	1.03e-05	2	112	2	7391573
Pubmed	Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.	C4A C4B	1.03e-05	2	112	2	17971360
Pubmed	Characterization of the interaction of phorbol esters with the C1 domain of MRCK (myotonic dystrophy kinase-related Cdc42 binding kinase) alpha/beta.	CDC42BPA CDC42BPB	1.03e-05	2	112	2	18263588
Pubmed	Clinical features of patients with homozygous complement C4A or C4B deficiency.	C4A C4B	1.03e-05	2	112	2	29928053
Pubmed	Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.	C4A C4B	1.03e-05	2	112	2	17971229
Pubmed	Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.	C4A C4B	1.03e-05	2	112	2	6881182
Pubmed	Partial C4 deficiency in juvenile idiopathic arthritis patients.	C4A C4B	1.03e-05	2	112	2	17921792
Pubmed	Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.	C4A C4B	1.03e-05	2	112	2	21880985
Pubmed	Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.	C4A C4B	1.03e-05	2	112	2	6978711
Pubmed	Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD.	C4A C4B	1.03e-05	2	112	2	35898513
Pubmed	Protein phosphatase 2A and complement component 4 are linked to the protective effect of APOE ɛ2 for Alzheimer's disease.	PPP2CB C4A	1.03e-05	2	112	2	35142023
Pubmed	Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival.	C4A C4B	1.03e-05	2	112	2	28873507
Pubmed	Studies on the murine Ss protein: demonstration that the Ss protein is functionally the fourth component of complement.	C4A C4B	1.03e-05	2	112	2	276882
Pubmed	Amino acid sequence of a polymorphic segment from fragment C4d of human complement component C4.	C4A C4B	1.03e-05	2	112	2	6832377
Pubmed	Recombination of two homologous MHC class III genes of the mouse (C4 and Slp) that accounts for the loss of testosterone dependence of sex-limited protein expression.	C4A C4B	1.03e-05	2	112	2	3794341
Pubmed	Regional expression of protein phosphatase type 1 and 2A catalytic subunit isoforms in the human heart.	PPP2CA PPP2CB	1.03e-05	2	112	2	11113010
Pubmed	Fine-tuned characterization of RCCX copy number variants and their relationship with extended MHC haplotypes.	C4A C4B	1.03e-05	2	112	2	22785613
Pubmed	Association between complement 4 copy number variation and systemic lupus erythematosus: a meta-analysis.	C4A C4B	1.03e-05	2	112	2	32691186
Pubmed	The androgen-dependent C4-Slp gene is driven by a constitutively competent promoter.	C4A C4B	1.03e-05	2	112	2	8390682
Pubmed	Structure and expression of murine fourth complement component (C4) and sex-limited protein (Slp).	C4A C4B	1.03e-05	2	112	2	3902619
Pubmed	Structural polymorphism of murine C4 and its linkage to H-2.	C4A C4B	1.03e-05	2	112	2	7373044
Pubmed	The chemical structure of the C4d fragment of the human complement component C4.	C4A C4B	1.03e-05	2	112	2	3696167
Pubmed	Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.	C4A C4B	1.03e-05	2	112	2	1357031
Pubmed	Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.	C4A C4B	1.03e-05	2	112	2	16098595
Pubmed	Mutations associated with a congenital form of ichthyosis (NCIE) inactivate the epidermal lipoxygenases 12R-LOX and eLOX3.	ALOXE3 ALOX12B	1.03e-05	2	112	2	15629692
Pubmed	Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.	C4A C4B	1.03e-05	2	112	2	15787745
Pubmed	Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.	C4A C4B	1.03e-05	2	112	2	30026462
Pubmed	A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.	C4A C4B	1.03e-05	2	112	2	6559257
Pubmed	RBM10 promotes transformation-associated processes in small cell lung cancer and is directly regulated by RBM5.	RBM10 RBM5	1.03e-05	2	112	2	28662214
Pubmed	Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects.	C4A C4B	1.03e-05	2	112	2	34299197
Pubmed	Assessment of complement C4 gene copy number using the paralog ratio test.	C4A C4B	1.03e-05	2	112	2	20506482
Pubmed	Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.	C4A C4B	1.03e-05	2	112	2	12480675
Pubmed	Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.	C4A C4B	1.03e-05	2	112	2	26800705
Pubmed	The role of protein phosphatase 2A catalytic subunit Calpha in embryogenesis: evidence from sequence analysis and localization studies.	PPP2CA PPP2CB	1.03e-05	2	112	2	10543450
Pubmed	Murine complement C4 is not required for experimental autoimmune encephalomyelitis.	C4A C4B	1.03e-05	2	112	2	15390104
Pubmed	Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein.	C4A C4B	1.03e-05	2	112	2	1699796
Pubmed	Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp.	C4A C4B	1.03e-05	2	112	2	2997024
Pubmed	RPTP delta and the novel protein tyrosine phosphatase RPTP psi are expressed in restricted regions of the developing central nervous system.	PTPRD PTPRM	1.03e-05	2	112	2	8989520
Pubmed	Constitutive expression of Slp genes in mouse strain B10.WR directed by C4 regulatory sequences.	C4A C4B	1.03e-05	2	112	2	3624865
Pubmed	Determination of the loss of function complement C4 exon 29 CT insertion using a novel paralog-specific assay in healthy UK and Spanish populations.	C4A C4B	1.03e-05	2	112	2	21857912
Pubmed	Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein.	C4A C4B	1.03e-05	2	112	2	6208559
Pubmed	The role of the histocompatibility-2-linked Ss-Slp region in the control of mouse complement.	C4A C4B	1.03e-05	2	112	2	4514997
Pubmed	The importance of the lipoxygenase-hepoxilin pathway in the mammalian epidermal barrier.	ALOXE3 ALOX12B	1.03e-05	2	112	2	24021977
Pubmed	The inheritance of susceptibility to the Gross leukemia virus in mice.	C4A C4B	1.03e-05	2	112	2	5919331
Pubmed	An ancient provirus has imposed androgen regulation on the adjacent mouse sex-limited protein gene.	C4A C4B	1.03e-05	2	112	2	3167981
Pubmed	The dichotomous size variation of human complement C4 genes is mediated by a novel family of endogenous retroviruses, which also establishes species-specific genomic patterns among Old World primates.	C4A C4B	1.03e-05	2	112	2	7545960
Pubmed	Insights on the relationship between complement component C4 serum concentrations and C4 gene copy numbers in a Western Australian systemic lupus erythematosus cohort.	C4A C4B	1.03e-05	2	112	2	30041577
Pubmed	Complete cDNA sequence of the fourth component of murine complement.	C4A C4B	1.03e-05	2	112	2	3862104
Pubmed	The BS variant of C4 protects against age-related loss of white matter microstructural integrity.	C4A C4B	1.03e-05	2	112	2	34358307
Pubmed	Acute renal allograft rejection: diagnostic significance of focal peritubular capillary C4d.	C4A C4B	1.03e-05	2	112	2	18360261
Pubmed	Molecular analysis of 250 patients with autosomal recessive congenital ichthyosis: evidence for mutation hotspots in ALOXE3 and allelic heterogeneity in ALOX12B.	ALOXE3 ALOX12B	1.03e-05	2	112	2	19131948
Pubmed	Protein phosphatase 2A in the healthy and failing heart: New insights and therapeutic opportunities.	PPP2CA PPP2CB	1.03e-05	2	112	2	34902541
GeneFamily	C3 and PZP like, alpha-2-macroglobulin domain containing	CPAMD8 C4A C4B	7.68e-06	9	83	3	1234
GeneFamily	Fibronectin type III domain containing	COL20A1 IL20RB PTPRD PTPRM TRIM36 USH2A	9.41e-05	160	83	6	555
GeneFamily	Neuroblastoma breakpoint family	NBPF20 NBPF19 NBPF10	1.55e-04	23	83	3	662
GeneFamily	Calcium voltage-gated channel subunits\|Membrane associated guanylate kinases	MPP4 DLG1 MPP7	2.25e-04	26	83	3	904
GeneFamily	Arachidonate lipoxygenases	ALOXE3 ALOX12B	3.09e-04	6	83	2	407
GeneFamily	Protein phosphatase catalytic subunits\|EF-hand domain containing	PPP2CA PPP2CB	1.57e-03	13	83	2	693
GeneFamily	Dyneins, axonemal	DNAH12 DNAH8	2.71e-03	17	83	2	536
GeneFamily	Cadherin related	CDHR1 PCDH15	2.71e-03	17	83	2	24
GeneFamily	RNA binding motif containing	A1CF PUF60 RBM10 RBM5 SPEN	2.99e-03	213	83	5	725
GeneFamily	CD molecules\|Integrin alpha subunits	ITGA5 ITGAD	3.04e-03	18	83	2	1160
GeneFamily	Protein phosphatase catalytic subunits\|STRIPAK complex	PPP2CA PPP2CB	3.75e-03	20	83	2	1371
GeneFamily	Protein tyrosine phosphatases, receptor type	PTPRD PTPRM	4.13e-03	21	83	2	813
GeneFamily	Zinc fingers RANBP2-type \|RNA binding motif containing	RBM10 RBM5	4.13e-03	21	83	2	89
GeneFamily	G-patch domain containing\|Minor histocompatibility antigens	RBM10 RBM5	4.53e-03	22	83	2	579
GeneFamily	PWWP domain containing	PWWP3A PWWP3B	4.53e-03	22	83	2	1147
ToppCell	healthy_donor-Myeloid-Monocytic-Neutrophil\|healthy_donor / Disease condition, Lineage, Cell class and subclass	LITAF FPR2 NCF1 C5AR2 ACSL1 BMX ELAPOR1 PADI2	1.09e-08	168	112	8	04259f5a9b067cd1b5619e34591e4b2fccc18535
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FRAS1 ISYNA1 B3GLCT PTPRM COL21A1 PCDH15 TRIM36	4.98e-07	188	112	7	0501a8aa850bd2e347020abd1cac4d8075738189
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_naive-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FLNA FPR2 LIPN ACSL1 LOXHD1 NBPF10 MPP7	5.54e-07	191	112	7	63d4226a8b59f648bdc9f41e4b2d750dfa342034
ToppCell	CF-Myeloid\|CF / Disease state, Lineage and Cell class	FLNA LITAF FPR2 LIPN ITGA5 ACSL1 SBF2	6.36e-07	195	112	7	ecf604de496f389a49429d0bb211e1db6019cc8b
ToppCell	Control-Control-Myeloid-Neutrophil\|Control / Disease, condition lineage and cell class	LITAF FPR2 NCF1 ACSL1 ELAPOR1 NBPF10 PADI2	7.54e-07	200	112	7	95c41f147a1594d49e73cb56d86d301c3115ce20
ToppCell	facs-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FPR2 ADCY3 TRPV4 ALOXE3 CMKLR1 TRIM36	4.27e-06	168	112	6	04e168fe1d6f5f9e3d3bf9d7c13e800e3594868a
ToppCell	facs-Marrow-Granulocytes-18m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA LITAF FPR2 NCF1 C5AR2 BMX	4.42e-06	169	112	6	2341eddfedaad8cee779c37bb87f7def058588ca
ToppCell	facs-Marrow-Granulocytes-18m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA LITAF FPR2 NCF1 C5AR2 BMX	4.42e-06	169	112	6	94871936ccfc73b56d425373b989b87c059d4493
ToppCell	10x5'-GI_small-bowel-Lymphocytic_NK-NK_CD16\|GI_small-bowel / Manually curated celltypes from each tissue	FLNA LITAF ADGRG1 EOMES EFHC2 CMKLR1	4.73e-06	171	112	6	1ee505b91f15191d294a5d491ecdf154c08b8622
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATRN FLNA FPR2 NCF1 ACSL1 BMX	5.77e-06	177	112	6	065bebd22031f143e90a407f952b444a3f8818c7
ToppCell	368C-Lymphocytic-NK_cells-NK_cell_E\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CDC42BPA CDC42BPB PTPRD COL21A1 PWWP3A SPEN	5.77e-06	177	112	6	946803293a7955116c80f403e99e4093e798ca3f
ToppCell	facs-Marrow-Granulocytes-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATRN FLNA FPR2 NCF1 ACSL1 BMX	5.77e-06	177	112	6	eb304f20aab075bd17aa3aef819386c0e1a235bd
ToppCell	COVID-19_Severe-Neutrophil-\|COVID-19_Severe / Disease condition and Cell class	LITAF FPR2 NCF1 ACSL1 BMX ELAPOR1	6.56e-06	181	112	6	5e5101195d5ff8c8ea7ddcf0bc4f4e03e64c01e0
ToppCell	COVID-19_Severe-Neutrophil\|COVID-19_Severe / Disease condition and Cell class	LITAF FPR2 NCF1 ACSL1 BMX ELAPOR1	6.56e-06	181	112	6	aa5e5fb0308b5e2ef918548c85529c9a433c57f5
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c11-MKI67-FOS\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ATRN B3GLCT PUF60 COX11 TMEM104 ADCY3	6.98e-06	183	112	6	ba7753e9fe2a6a87c5264f299ac97da2ddbda178
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 CPS1 LOXHD1 PTPRD PCDH15 USH2A	7.20e-06	184	112	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 CPS1 LOXHD1 PTPRD PCDH15 USH2A	7.20e-06	184	112	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 CPS1 LOXHD1 PTPRD PCDH15 USH2A	7.20e-06	184	112	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	COVID_non-vent-Myeloid-Monocytic-Neutrophil\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	LITAF FPR2 NCF1 ACSL1 BMX PADI2	7.43e-06	185	112	6	2c89af7cdf5306b900a5b8ec4fdfb8210e5667ed
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_0\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	LITAF FPR2 NCF1 ACSL1 BMX PADI2	7.90e-06	187	112	6	75bc05a0ba2727fecc236903ace792a28f3d3c9a
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_0\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	LITAF FPR2 NCF1 ACSL1 BMX PADI2	7.90e-06	187	112	6	a0d59bf1043ff5a1e8110b39ecc2d3932675edd4
ToppCell	10x5'v1-week_12-13-Hematopoietic-HSC/MPP_and_pro-ELP\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	ISYNA1 ACY3 ADGRG1 ITGAD MEF2C BAHCC1	8.14e-06	188	112	6	0a47de24812c619f6756c9351a413b109128d54f
ToppCell	COVID-19_Severe-Myeloid_G-Neutrophil\|COVID-19_Severe / Disease group, lineage and cell class	LITAF FPR2 NCF1 ACSL1 BMX PADI2	8.39e-06	189	112	6	a62f4c445ede00d15b74bee65f4e4fb54cfd4d32
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	LITAF FPR2 NCF1 ACSL1 BMX PADI2	8.39e-06	189	112	6	f6b2b4824505f0119a017fdb73c55418fb651645
ToppCell	cellseq-Immune-Hematopoietic-Granulocytic-Neutrophil\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	LITAF FPR2 NCF1 ACSL1 BMX PADI2	8.39e-06	189	112	6	fedab592be1d6520325b8c1b659b0a4dc3f4fe4d
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	LITAF FPR2 NCF1 ACSL1 BMX PADI2	8.39e-06	189	112	6	db8e314ce95c32542bb4015a77032a33211fea0b
ToppCell	10x5'v1-week_14-16-Hematopoietic-HSC/MPP_and_pro-ELP\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	ISYNA1 ACY3 ADGRG1 ITGAD MEF2C BAHCC1	8.39e-06	189	112	6	46c3f3dff71e7131a5ad1cd3b68709051a474c3c
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_hypoxia-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FLNA LIPN ITGA5 ACSL1 LOXHD1 NBPF10	9.46e-06	193	112	6	5703a6faaee82cbad5ce73429bdf1b0f47b37ee0
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FLNA ISYNA1 ADCY3 MEF2C AEBP1 COL21A1	9.74e-06	194	112	6	5099e6ad7c19e5f8b73449d904aaefd97f1b1959
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FLNA ISYNA1 ADCY3 MEF2C AEBP1 COL21A1	9.74e-06	194	112	6	71734ef7b34ab33b349595368176fa0e1175d4d0
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FLNA ISYNA1 ADCY3 MEF2C AEBP1 COL21A1	1.00e-05	195	112	6	e10b21e4dba4483efc4c82d6e395524246ca14a8
ToppCell	COVID-19_Severe-CD8+_Tem\|COVID-19_Severe / Disease condition and Cell class	FLNA LITAF ADGRG1 EOMES PTPRM CMKLR1	1.00e-05	195	112	6	ff7ae62393e1c858a10592db8e6d9f36b8bae396
ToppCell	wk_15-18-Hematologic-Myeloid-Neutrophil\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	FPR2 NCF1 LIPN ACSL1 LOXHD1 PADI2	1.03e-05	196	112	6	36c01e0feea33448222010c21442b9fac671bd7d
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FLNA ISYNA1 ADCY3 MEF2C AEBP1 COL21A1	1.03e-05	196	112	6	5146976881d79642ebe5dcbcf89e0252713a9ef2
ToppCell	NS-moderate-d_07-13-Myeloid\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	FLNA LITAF FPR2 NCF1 ITGA5 ACSL1	1.03e-05	196	112	6	e5c7ef2f092ad082698f014f9c5ba1ff4d07b93f
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Myeloid\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	FLNA LITAF FPR2 NCF1 ACSL1 NBPF19	1.03e-05	196	112	6	ff88e5b919b1be93159ad2200a7786d1c5272724
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FLNA ISYNA1 ADCY3 MEF2C AEBP1 COL21A1	1.03e-05	196	112	6	ebac1d6af7a5732707d82d01285c086b19d8ae62
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FLNA ISYNA1 ADCY3 MEF2C AEBP1 COL21A1	1.06e-05	197	112	6	bc6c530330907a5ec823cc243c8e9c9e340cfb9c
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FLNA ISYNA1 ADCY3 MEF2C AEBP1 COL21A1	1.06e-05	197	112	6	d14e1f2ba94240c61eac435db43508a224d606a8
ToppCell	10x5'v1-week_12-13-Myeloid_neutrophil-granulo-neutrophil-neutrophil\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	LITAF FPR2 NCF1 ACSL1 BMX PADI2	1.06e-05	197	112	6	8dd10962b6ba587512b2e68c762ade68c751cbc8
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FLNA ISYNA1 ADCY3 MEF2C AEBP1 COL21A1	1.06e-05	197	112	6	77fe092aae8f05fe137680506892d2f61071d6ea
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FLNA ISYNA1 ADCY3 MEF2C AEBP1 COL21A1	1.09e-05	198	112	6	54c8aa47040bc4977eed382514fc4ceae03f54f8
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FLNA ISYNA1 ADCY3 MEF2C AEBP1 COL21A1	1.09e-05	198	112	6	daf367b699726286f0f0f7b4f3a6cf70c462fbeb
ToppCell	LPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	REV3L FASN PTPRD TENM3 COL21A1 PCDH15	1.13e-05	199	112	6	8b86c69aaf60feff53aa782559cfece7342a23de
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW23-OPC_related\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	B3GLCT COL20A1 LITAF ADGRG1 PCDH15 ARC	1.16e-05	200	112	6	439265194cb08d1373296bf8684cc31294cecb20
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Artery\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	IL20RB ADGRG1 BMX PTPRM COL21A1 ITSN2	1.16e-05	200	112	6	ac9ead34afa14067171833f5c277eaf06db7b02e
ToppCell	severe-Neutrophil\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	LITAF FPR2 NCF1 ACSL1 BMX PADI2	1.16e-05	200	112	6	f04d5951bac4dee47c22aaf7973312ca797f322e
ToppCell	Bronchus_Control_(B.)-Immune-TX-MoAM-1\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	FLNA LITAF FPR2 ITGA5 ACSL1 NBPF19	1.16e-05	200	112	6	fe7f8b04067b6680b69c8523f0fa514ef97207e2
ToppCell	LPS_only-Endothelial-Endothelial-Artery\|LPS_only / Treatment groups by lineage, cell group, cell type	IL20RB ADGRG1 MEF2C BMX PTPRM ARC	1.16e-05	200	112	6	b17eb1587ca86c3d40515128a00a8d8fd787fccf
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW23-OPC_related-OPC\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	B3GLCT COL20A1 LITAF ADGRG1 PCDH15 ARC	1.16e-05	200	112	6	0450a79c5fae5ccacdb990ae674e4734ef0c3691
ToppCell	367C-Epithelial_cells-Epithelial-D_(AT2)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	ACVR1C SERF1A MEF2C FASN LAMP3	2.89e-05	141	112	5	f3b1d757c4cac8596c542959c8f27f8bcaf3f513
ToppCell	367C-Epithelial_cells-Epithelial-D_(AT2)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	ACVR1C SERF1A MEF2C FASN LAMP3	2.89e-05	141	112	5	bf68a54e755cda89fbc416636e522cd71d1e42d0
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L2/3_IT-L2/3_IT_ALM_Macc1_Lrg1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TMC1 RADX ACVR1C RYR1 ALOX12B	2.98e-05	142	112	5	d08e1880425d285c4433014fe0242ac7ff7734af
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 A1CF CPS1 PCDH15 USH2A	3.30e-05	145	112	5	96712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCell	facs-Marrow-T-cells-24m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA FPR2 NCF1 BPIFB6 BMX	4.00e-05	151	112	5	ced4f7ee377a23a804ae6fde624e8b55b79f1fd8
ToppCell	facs-Marrow-T-cells-24m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA FPR2 NCF1 BPIFB6 BMX	4.00e-05	151	112	5	b52bb3b88e9a6473f571053537b8beb418678539
ToppCell	Adult-Epithelial-basal_cell-D122\|Adult / Lineage, Cell type, age group and donor	FRAS1 ISYNA1 ADGRG1 ELAPOR1 TRPV4	4.40e-05	154	112	5	38d346402417960044ae999e61f0092b46f2b591
ToppCell	5'-Adult-Appendix-Epithelial-Tuft-related-Tuft\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TMC1 BMX ELAPOR1 ADAMTS18 ALOX12B	4.68e-05	156	112	5	58b9520fce6e259b36c3d59e82b712f5e7729e3e
ToppCell	PND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ITGAD EOMES ORC2 ARC PADI2	4.68e-05	156	112	5	33deda19f06172079ef1dd49fd54d66da1e7fb14
ToppCell	facs-Liver-Hepatocytes\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CPS1 TM6SF2 ACSL1 PTPRD C4B	4.68e-05	156	112	5	e2cda3ad4e5f44a80133864c5a38b766afb952ce
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Myeloid\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPAM1 CDHR1 NCF1 CMKLR1 SLC5A12	4.82e-05	157	112	5	7fdc0094dd5729990a91a30c1982a14c74650b52
ToppCell	3'_v3-blood-Lymphocytic_Invariant-Inducer-like-ILC3\|blood / Manually curated celltypes from each tissue	IL20RB ITGAD EFHC2 PTPRD CCDC40	4.82e-05	157	112	5	eb2520c237543ea4869d4386afc0457b111f6193
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Myeloid-microglial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPAM1 CDHR1 NCF1 CMKLR1 SLC5A12	4.82e-05	157	112	5	c762b03e254c73222094725ca8ac1c8eb428bccb
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Myeloid-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPAM1 CDHR1 NCF1 CMKLR1 SLC5A12	4.82e-05	157	112	5	6b5b08bb5520fcf6f4c0560f7ed7645ec179806d
ToppCell	PBMC-Control-Myeloid-Neutrophil-Neutrophil-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	B3GLCT ACSL1 ERCC8 ELAPOR1 PADI2	5.27e-05	160	112	5	70f3637dd0bcfcef421aa114f946fff0048f192e
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FRAS1 A1CF CPS1 PCDH15 USH2A	5.59e-05	162	112	5	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	facs-Heart-LV-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL20A1 FPR2 NCF1 CDKL1 MPP4	6.10e-05	165	112	5	84eca6a0f5e996b6955ae79fa102af239098fe8f
ToppCell	facs-Heart-LV-3m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL20A1 FPR2 NCF1 CDKL1 MPP4	6.10e-05	165	112	5	af59a095ecc6758abc13d763c00e44447c488167
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FRAS1 IL22RA1 TENM3 AEBP1 C4B	6.46e-05	167	112	5	7abc785e688a384672d7fb5a62d32538fe7e5a51
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FRAS1 IL22RA1 TENM3 AEBP1 C4B	6.46e-05	167	112	5	d50311b1f66f143bae4c4cf50e2e9b13c85d6920
ToppCell	facs-Liver-Hepatocytes-24m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FPR2 ADCY3 TRPV4 ALOXE3 CMKLR1	6.65e-05	168	112	5	4ae9e9d93bcd6f4d5815e57fd5afa7a3398a0ec1
ToppCell	3'-GW_trimst-1-SmallIntestine-Epithelial-neuro-epithelial-L_cells_(PYY+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	A1CF IL20RB CFAP65 EFHC2 ELAPOR1	6.65e-05	168	112	5	0f736d58cb0ff042fa3ce58e36bde37b6976f8fc
ToppCell	facs-Marrow-Granulocytes-18m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LITAF FPR2 NCF1 C5AR2 BMX	6.83e-05	169	112	5	a5964aef04093b460bbe29d5e2e7389f8fd2d46f
ToppCell	facs-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FPR2 ADCY3 TRPV4 ALOXE3 CMKLR1	6.83e-05	169	112	5	454b92b9b67299a64278c010db033ca5b9d217a0
ToppCell	facs-Marrow-Granulocytes-18m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LITAF FPR2 NCF1 C5AR2 BMX	6.83e-05	169	112	5	e0076aa61b4ef3f836f5750005d0469d3982eb6d
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 AEBP1 PCDH15 C4B USH2A	6.83e-05	169	112	5	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	facs-Heart-LV-18m-Lymphocytic-T_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGAD FAAH CCR8 PADI2 DNAH8	7.03e-05	170	112	5	71e5e27c3c4e6cc8dc9b063bd51c21c049f54416
ToppCell	facs-Heart-LV-18m-Lymphocytic-T_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGAD FAAH CCR8 PADI2 DNAH8	7.03e-05	170	112	5	255bbbd00d0e17510c5a8c5faa43ed90d887a9de
ToppCell	facs-Marrow-T-cells-3m-Hematologic-MPP_Fraction_B_+_C\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B3GLCT ZP1 TRPV4 CCDC40 BAHCC1	7.03e-05	170	112	5	d70aaa0f4e5034bb9f61b832b5f9123870936d3c
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA FPR2 NCF1 ACSL1 BMX	7.23e-05	171	112	5	ab21f20ec041cbaacccbd7da4dccdb77ec8bc5c6
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA FPR2 NCF1 ACSL1 BMX	7.23e-05	171	112	5	97ad2cfff568a9d006ab1d2e6e00946ee4e3beb3
ToppCell	droplet-Liver-Hepatocytes-21m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCF1 C5AR2 FAP TRPV4 CMKLR1	7.43e-05	172	112	5	574ebdf36e45222bcd907cd2c2ee7ff50ed4573a
ToppCell	droplet-Liver-Hepatocytes-21m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCF1 C5AR2 FAP TRPV4 CMKLR1	7.43e-05	172	112	5	1627fa7035b0e0bbc82a1c0f000d8231254c680a
ToppCell	E16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ATRN FPR2 LIPN ACSL1 CMKLR1	7.63e-05	173	112	5	20f7dfe7d92a3dbec9da9a1f3185aa10cb8f0a3c
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FRAS1 PTPRD TENM3 AEBP1 C4B	7.63e-05	173	112	5	30d67738633493d47f06ae452424382f069b6c0a
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	A1CF PTPRD PCDH15 TRPV4 SLC5A12	7.63e-05	173	112	5	8888434641ea554a9b62c436e87920378eef29cd
ToppCell	severe_influenza-Neutrophil\|World / disease group, cell group and cell class (v2)	LITAF FPR2 NCF1 ACSL1 BMX	7.84e-05	174	112	5	f9f07436b7d3f190800cd85d229f007032f391e1
ToppCell	10x5'-GI_small-bowel-Lymphocytic_NK\|GI_small-bowel / Manually curated celltypes from each tissue	LITAF CDHR1 ADGRG1 EOMES ADAMTS18	7.84e-05	174	112	5	09b216f07cffd3ea2149ea95ffb5cd7219b3a98c
ToppCell	Mesenchymal_cells-Osteo-CAR\|Mesenchymal_cells / Lineage and Cell class	TM6SF2 IFNAR2 FAP DNAH12 PTPRD	7.84e-05	174	112	5	430e3cd61bc2a471959faa40e817aa4dd7d82d28
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CPAMD8 LITAF LOXHD1 ADAMTS18 MPP7	8.06e-05	175	112	5	77c16e615c0fb9c83f29d7e0a547be72635fac81
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	FRAS1 ACVR1C MEF2C ADAMTS18 ALOX12B	8.06e-05	175	112	5	ff0789f5913c9f3c49159e40b1ec3d2ff175ec9f
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CPAMD8 LITAF LOXHD1 ADAMTS18 MPP7	8.06e-05	175	112	5	98947a226b5a2ac7091ff9d34243ea7736add973
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	FRAS1 ACVR1C MEF2C ADAMTS18 ALOX12B	8.06e-05	175	112	5	21f8f11a8b874d4f7c47931010a2535f2a5a3373
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CPAMD8 LITAF LOXHD1 ADAMTS18 MPP7	8.28e-05	176	112	5	25ebc8716aa44e44fce577701e3e82c6745a75ab
ToppCell	wk_20-22-Endothelial-Blood_vessel_endothelial-OMD+_endo\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	CPAMD8 TMC1 ITGA5 BMX PTPRM	8.28e-05	176	112	5	52af8f717dbd3b59eeb868b8b7b256a8f3e57d7a
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_26.46.91\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	RADX AEBP1 COL21A1 LAMP3 BAHCC1	8.28e-05	176	112	5	29b71369503719c74888cd356ceb6724cfdcabd9
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Granulocytic-Neutrophil\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LITAF FPR2 NCF1 C5AR2 ACSL1	8.50e-05	177	112	5	ed44b1bf2ffae97f94e944d1b6060d5163eba6a6
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CPAMD8 LITAF LOXHD1 ADAMTS18 MPP7	8.96e-05	179	112	5	e6ae070b4c52ba08167c7d64ea4cfbac0454c1bf
ToppCell	ASK452-Immune-B_cell\|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq	CDC42BPA RBM10 AEBP1 ELAPOR1 ARC	8.96e-05	179	112	5	c3cf49c069e66db16d2fce1de4c52a4c4fe7e832
ToppCell	COVID-19-Heart-EC_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CPAMD8 CDC42BPA MEF2C BMX PTPRM	8.96e-05	179	112	5	2a53d94f6c30bf887dfe88f1693ea057218c852d
Disease	azoospermia (implicated_via_orthology)	ISYNA1 CDC42BPA CDC42BPB PTPRD	2.59e-06	27	106	4	DOID:14227 (implicated_via_orthology)
Disease	Congenital Nonbullous Ichthyosiform Erythroderma	LIPN ALOXE3 ALOX12B	7.28e-06	11	106	3	C0079154
Disease	Congenital ichthyosis of skin	LIPN ALOXE3 ALOX12B	7.28e-06	11	106	3	cv:C0020758
Disease	short-term memory	GPR6 DNAH12 PTPRD ITSN2 PCDH15	1.26e-05	83	106	5	EFO_0004335
Disease	ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 2	ALOXE3 ALOX12B	1.28e-05	2	106	2	242100
Disease	Autosomal recessive congenital ichthyosis 2	ALOXE3 ALOX12B	1.28e-05	2	106	2	cv:C3888093
Disease	ICHTHYOSIFORM ERYTHRODERMA, CONGENITAL, NONBULLOUS, 1	ALOXE3 ALOX12B	1.28e-05	2	106	2	C1855792
Disease	Self-Healing Collodion Baby	ALOXE3 ALOX12B	3.83e-05	3	106	2	C1855789
Disease	human papilloma virus infection, oropharynx cancer	PSG1 CPS1 TENM3 PADI2	4.02e-05	53	106	4	EFO_0001668, EFO_1001931
Disease	Ichthyosis Congenita I	ALOXE3 ALOX12B	7.63e-05	4	106	2	C4551630
Disease	Harlequin Fetus	ALOXE3 ALOX12B	7.63e-05	4	106	2	C0239849
Disease	Ichthyosis Congenita II	ALOXE3 ALOX12B	7.63e-05	4	106	2	C3536797
Disease	Collodion Fetus	ALOXE3 ALOX12B	7.63e-05	4	106	2	C3543867
Disease	Congenital ichthyosis	ALOXE3 ALOX12B	1.27e-04	5	106	2	C0020758
Disease	Usher Syndrome, Type II	PCDH15 USH2A	1.27e-04	5	106	2	C1568249
Disease	X-16570 measurement	CPS1 FAAH	1.90e-04	6	106	2	EFO_0800759
Disease	N-palmitoylglycine measurement	CPS1 FAAH	2.65e-04	7	106	2	EFO_0800342
Disease	asthma, response to diisocyanate	ATRN RYR1 PTPRD TENM3 SLC5A12 MPP7	3.69e-04	261	106	6	EFO_0006995, MONDO_0004979
Disease	hearing impairment	TMC1 LOXHD1 PCDH15 USH2A	4.38e-04	98	106	4	C1384666
Disease	Charcot-Marie-Tooth disease	LITAF SBF2 TRPV4	4.67e-04	42	106	3	cv:C0007959
Disease	liver fat measurement	HSP90B2P TM6SF2 SPEN	5.01e-04	43	106	3	EFO_0010821
Disease	temporomandibular joint disorder	B3GLCT BAHCC1	5.65e-04	10	106	2	EFO_0005279
Disease	Ciliopathies	PCDH15 USH2A DNAH8 CCDC40	6.78e-04	110	106	4	C4277690
Disease	polybrominated biphenyl measurement, gestational serum measurement, fetal genotype effect measurement, polybrominated diphenyl ether measurement	LOXHD1 PTPRM	6.88e-04	11	106	2	EFO_0007959, EFO_0007961, EFO_0007962, EFO_0007964
Disease	cerebral cavernous malformation (implicated_via_orthology)	CDC42BPA CDC42BPB	6.88e-04	11	106	2	DOID:0060669 (implicated_via_orthology)
Disease	peanut allergy measurement, parental genotype effect measurement	RYR1 PWWP3A	6.88e-04	11	106	2	EFO_0005939, EFO_0007017
Disease	Drug habituation	FAAH PCDH15 DNAH8 MPP7	8.01e-04	115	106	4	C0013170
Disease	Drug abuse	FAAH PCDH15 DNAH8 MPP7	8.01e-04	115	106	4	C0013146
Disease	Prescription Drug Abuse	FAAH PCDH15 DNAH8 MPP7	8.01e-04	115	106	4	C4316881
Disease	Substance-Related Disorders	FAAH PCDH15 DNAH8 MPP7	8.01e-04	115	106	4	C0236969
Disease	Drug Use Disorders	FAAH PCDH15 DNAH8 MPP7	8.01e-04	115	106	4	C0013222
Disease	Drug Dependence	FAAH PCDH15 DNAH8 MPP7	8.01e-04	115	106	4	C1510472
Disease	Substance Dependence	FAAH PCDH15 DNAH8 MPP7	8.01e-04	115	106	4	C0038580
Disease	Substance Use Disorders	FAAH PCDH15 DNAH8 MPP7	8.01e-04	115	106	4	C0038586
Disease	Organic Mental Disorders, Substance-Induced	FAAH PCDH15 DNAH8 MPP7	8.01e-04	115	106	4	C0029231
Disease	Substance abuse problem	FAAH PCDH15 DNAH8 MPP7	8.27e-04	116	106	4	C0740858
Disease	Nonsyndromic Hearing Loss and Deafness, Autosomal Recessive	TMC1 LOXHD1 PCDH15	8.28e-04	51	106	3	cv:CN043650
Disease	Cocaine-Related Disorders	TENM3 COL21A1 ARC DNAH8	8.54e-04	117	106	4	C0236736
Disease	smoking status measurement	HSP90B2P CDC42BPA REV3L CDC42BPB ADCY3 ERCC8 PTPRD PCDH15 ARC CMKLR1 USH2A DNAH8	9.45e-04	1160	106	12	EFO_0006527
Disease	Sjogren's Syndrome	NCF1 ITSN2	9.72e-04	13	106	2	C1527336
Disease	Sicca Syndrome	NCF1 ITSN2	9.72e-04	13	106	2	C0086981
Disease	Disorder of eye	FRAS1 B3GLCT CDHR1 PCDH15 USH2A	1.03e-03	212	106	5	C0015397
Disease	essential hypertension, age at diagnosis	B3GLCT TRIM36 BAHCC1	1.09e-03	56	106	3	EFO_0004918, MONDO_0001134
Disease	cerebellum cortex volume change measurement	PTPRD PTPRM	1.13e-03	14	106	2	EFO_0021497
Disease	diffuse large B-cell lymphoma	CDC42BPB ITSN2	1.13e-03	14	106	2	EFO_0000403
Disease	Cocaine Abuse	TENM3 COL21A1 ARC DNAH8	1.16e-03	127	106	4	C0009171
Disease	monocyte percentage of leukocytes	HSP90B2P CDC42BPA PSG1 LITAF MEF2C DNAH12 ITSN2 CMKLR1 BAHCC1	1.30e-03	731	106	9	EFO_0007989
Disease	Spondyloepiphyseal Dysplasia	FLNA TRPV4	1.48e-03	16	106	2	C0038015
Disease	Spondyloepiphyseal Dysplasia Tarda, X-Linked	FLNA TRPV4	1.48e-03	16	106	2	C3541456
Disease	Schwartz-Jampel Syndrome, Type 1	FLNA TRPV4	1.48e-03	16	106	2	C4551479
Disease	Schwartz-Jampel Syndrome	FLNA TRPV4	1.48e-03	16	106	2	C0036391
Disease	Melnick-Needles Syndrome	FLNA TRPV4	1.48e-03	16	106	2	C0025237
Disease	Cocaine Dependence	TENM3 COL21A1 ARC DNAH8	1.62e-03	139	106	4	C0600427
Disease	iritis	PSG1 TNRC18	1.68e-03	17	106	2	EFO_1000997
Disease	Van Buchem disease	FLNA TRPV4	1.68e-03	17	106	2	C0432272
Disease	androstenedione measurement, estrone measurement	PTPRD PTPRM	1.88e-03	18	106	2	EFO_0007970, EFO_0007972
Disease	Alzheimer disease, educational attainment	IP6K1 MEF2C ERCC8 RBM5 TRIM36	2.01e-03	247	106	5	EFO_0011015, MONDO_0004975
Disease	Osteochondrodysplasias	FLNA TRPV4	2.10e-03	19	106	2	C0029422
Disease	Dyschondroplasias	FLNA TRPV4	2.10e-03	19	106	2	C0013366
Disease	Lupus Erythematosus, Systemic	NCF1 C4A C4B	2.16e-03	71	106	3	C0024141
Disease	serum metabolite measurement	CDC42BPA ZNF862 ACY3 PTDSS1 REV3L CPS1 TM6SF2 FAAH TENM3 PCDH15	2.16e-03	945	106	10	EFO_0005653
Disease	Multiple Epiphyseal Dysplasia	FLNA TRPV4	2.33e-03	20	106	2	C0026760
Disease	intellectual disability (implicated_via_orthology)	ITGA5 MEF2C ITSN2	2.52e-03	75	106	3	DOID:1059 (implicated_via_orthology)
Disease	DNA methylation	SPAM1 LITAF ACSL1 TENM3 PTPRM ADAMTS18 CMKLR1 USH2A	2.56e-03	656	106	8	GO_0006306
Disease	Nonsyndromic genetic hearing loss	TMC1 LOXHD1 PCDH15	2.62e-03	76	106	3	cv:C5680182
Disease	Nonsyndromic Deafness	TMC1 LOXHD1 PCDH15	3.14e-03	81	106	3	C3711374

Protein segments in the cluster

Peptide	Gene	Start	Entry
FGVTYLEDYSAEYII	BCL2L13	181	Q9BXK5
YAPGYTQTSYSTEVP	BAG4	156	O95429
YESEYTSSTLLPYGI	EOMES	536	O95936
YYLAGTYDPTTGRLV	BAHCC1	2616	Q9P281
YYGYVYEDTLPGSEV	CDHR1	251	Q96JP9
STVYPVFINEAAYYE	ACY3	276	Q96HD9
SLIEYYSDYTENSIP	B3GLCT	296	Q6Y288
VGLVQPASATLYDYY	C4B	1546	P0C0L5
EYTYSLGQVYDPTTT	A1CF	326	Q9NQ94
LGQDLAAYTTYEVYP	A1CF	566	Q9NQ94
AAYTTYEVYPTFAVT	A1CF	571	Q9NQ94
EVLGCSVAPVYSYYA	AEBP1	536	Q8IUX7
PLVYFYDDVTTLYEG	ACSL1	81	P33121
YGVCSKEYPIYIVTE	BMX	476	P51813
EADGYDYTVSPYAIT	ARC	161	Q7LC44
SSYRGQEEYVLSYEP	DLG1	691	Q12959
LYIEVYPGTYSVTVG	AKIP1	171	Q9NQ31
SVGGIVEEYQLPYYD	ACVR1C	406	Q8NER5
YVFVTPVEVDSAGSY	ADAMTS18	61	Q8TE60
DPYTESYISTIGVDF	RAB1C	31	Q92928
VPDVSTYQYDETSGY	RBM10	566	P98175
SVGEEYIALYPYSSV	ITSN2	981	Q9NZM3
YGPEAIEAQYEYRTT	ISYNA1	16	Q9NPH2
PSYEETVAVNSYYPT	LITAF	21	Q99732
PLYCYDVTISDGVYQ	RADX	91	Q6NSI4
VLEYDARENGPYYTS	GDAP2	476	Q9NXN4
GYEVIYLTEPVVEYC	HSP90B2P	201	Q58FF3
CTVFSTVGYGYIYPV	KCNK18	111	Q7Z418
TSEIIIYNGYPSEEY	LIPN	36	Q5VXI9
IYNGYPSEEYEVTTE	LIPN	41	Q5VXI9
DYSGEYTIYLIPCTV	FRAS1	3601	Q86XX4
DPAVYTYATLLPATY	GPR6	306	P46095
DYYIEETLSTGPSYD	SBF2	1581	Q86WG5
EYEEVSYESAGYTVL	FPR2	11	P25090
SFVSEIVGYYYPSDA	ALOXE3	521	Q9BYJ1
YELYNGGSVPVTYEV	CFAP65	1321	Q6ZU64
LYVYDGDSIYAPLVA	ATRN	186	O75882
SGTVNFEYYYPDSSI	ELAPOR1	186	Q6UXG2
YTPFVPYEITLYTSD	LOXHD1	1096	Q8IVV2
PYEITLYTSDVFAAG	LOXHD1	1101	Q8IVV2
SYYLGDDTISVFEPI	EFHC2	456	Q5JST6
YRTVIEYYSASNGEP	NAA20	131	P61599
YAGEPYVAIKAYTAV	NCF1	226	P14598
YYPTDSIPEYSSILV	DNAH8	2416	Q96JB1
YDTADVPTYEEVTPY	MPP7	346	Q5T2T1
EYDTIPFEAISYLTG	DNAH12	2691	Q6ZR08
YSAVGAPYEEVVRYQ	MPP4	406	Q96JB8
YYISEVGAYLTVSDP	LAMP3	301	Q9UQV4
YPSAISTTYGTEYSL	MEF2C	311	Q06413
TYDALSPELYTTYFV	MT-ND1	246	P03886
YGETPFYAESLVETY	CDC42BPB	276	Q9Y5S2
YGSRVEAVYVLGTYL	PADI2	11	Q9Y2J8
YVDRGYYSVETVTLL	PPP2CB	86	P62714
YVDRGYYSVETVTLL	PPP2CA	86	P67775
VPDTSTYQYDESSGY	RBM5	456	P52756
PYGSTIAVYTVYSGE	ERCC8	311	Q13216
PVIAPGETVYYSVEY	IL20RB	56	Q6UXL0
ISLVFGISYDSPDYT	IFNAR2	21	P48551
SYGTVVSLYYPAGLS	ITGAD	811	Q13349
IYDDSYLGYSVAVGE	ITGA5	266	P08648
TPTFPEISYDVYVYT	PCDH15	506	Q96QU1
TLAAEYPSVTNYLYV	CPS1	946	P31327
VSYEYGDYSDLSDRP	C5AR2	6	Q9P296
LLAGPSDYYTDYVAT	CDKL1	151	Q00532
TEYDVTILAYYRDGA	COL20A1	711	Q9P218
YTPYEEGLHSVDVTY	FLNA	1321	P21333
SVEYIPYEAGTYSLN	FLNA	1411	P21333
DLSVTTVTDYYYPDI	CCR8	6	P51685
TEIYVVPGETALAFY	COX11	171	Q9Y6N1
GRTSALPVSVYDYYE	CPAMD8	1636	Q8IZJ3
LGVVYYVGDTFSEEY	DNAJB12	291	Q9NXW2
SEEEYYYTETSSPEG	CCDC40	91	Q4G0X9
PSSTYVFYVEDYIAI	COL21A1	186	Q96P44
YRLVVEVFGTYVPGY	ADGRG1	501	Q9Y653
EYSAEYSAEYSVSLP	ADCY3	11	O60266
TGFITSYLEEAYIPV	BPIFB6	401	Q8NFQ5
IITYYYPSDAAVEGD	ALOX12B	516	O75342
EGTPDTVYSIEYKTY	IL22RA1	46	Q8N6P7
DGYINLVAYPYVESE	IP6K1	86	Q92551
LGYYPYIDSITGVTV	SPAM1	96	P38567
EEVYTSSQPLRVGYY	FAAH	316	O00519
VTGVAYYQPSLTAEY	SDR39U1	106	Q9NRG7
ASVPVVYSTAYYALV	FASN	1646	P49327
DDPEIILNTTTYYYS	RYR1	1421	P21817
VGLVQPASATLYDYY	C4A	1546	P0C0L4
SYVVDGEIIIYGPAY	PSG1	81	P11464
PTQTYGVITLYEITY	PTPRM	506	P28827
TRYSVAGLSPYSDYE	PTPRD	376	P23468
PGVYDSSGIRVYYTS	MOXD2P	316	A6NHM9
YSPYTEETSYENSLL	ORC2	451	Q13416
GSFLEYYAADISYPV	PWWP3A	506	Q2TAK8
DFTLTPGVEYSYTVT	USH2A	4496	O75445
YYTSLDYIIGDTGIT	TRIM36	556	Q9NQ86
YYLAYGSITPISAFV	SERF1A	76	O75920
VYVGSIYYELGEDTI	PUF60	131	Q9UHX1
PYSSAVYSLEEQYLG	NBPF10	1706	Q6P3W6
PYSSAVYSLEEQYLG	NBPF10	2926	Q6P3W6
PYSSAVYSLEEQYLG	NBPF19	1191	A0A087WUL8
PYSSAVYSLEEQYLG	NBPF19	2411	A0A087WUL8
PYSSAVYSLEEQYLG	NBPF19	3631	A0A087WUL8
PYSSAVYSLEEQYLG	NBPF20	1091	P0DPF2
PYSSAVYSLEEQYLG	NBPF20	2311	P0DPF2
PYSSAVYSLEEQYLG	NBPF20	3531	P0DPF2
PYSSAVYSLEEQYLG	NBPF20	4601	P0DPF2
PYSSAVYSLEEQYLG	NBPF20	4751	P0DPF2
TGSLLEYYAADISYP	PWWP3B	486	Q5H9M0
LYGETPFYAESLVET	CDC42BPA	276	Q5VT25
LEYGYPSYTEFDISG	TMC1	561	Q8TDI8
SISYGDEYPDYLDSI	CMKLR1	11	Q99788
FNDTDIPVIAYSYYG	FAP	226	Q12884
SEGLYYLAGTYEPTT	TNRC18	2941	O15417
TFSSYYGEDDYPIVR	ZP1	416	P60852
TYYESVRTPGTYPED	SPEN	631	Q96T58
DNYYISYSSPDSPVI	REV3L	2111	O60673
TETGELYSSYVGLVY	TMEM104	6	Q8NE00
VYGLSEAVVSVGYEY	TENM3	1071	Q9P273
RYYLATDPVTGDLYV	TENM3	1216	Q9P273
YITLAPLYSETADGY	ZNF862	656	O60290
PLYSETADGYFETIV	ZNF862	661	O60290
DSYSYVRSTAPAVAY	ZFR	141	Q96KR1
FPEISRGEYLYTYDS	ZNF8	191	P17098
SYVYSGYAPLSVRLA	VPS33A	486	Q96AX1
VYSLSHGEVSYDPLY	TM6SF2	51	Q9BZW4
PYTFLETVCIYGYSL	YIPF2	196	Q9BWQ6
PVFYRSGITSTYEYL	SLC5A12	101	Q1EHB4
TAPTVRQYYAYLTDT	PTDSS1	331	P48651
YGPVYSSLYDLSSLD	TRPV4	411	Q9HBA0