Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionextracellular matrix constituent, lubricant activity

MUC17 MUC3A

2.58e-054422GO:0030197
MousePhenodecreased circulating luteinizing hormone level

GHR LATS1 CLOCK

1.16e-0521303MP:0002773
MousePhenodecreased luteinizing hormone level

GHR LATS1 CLOCK

4.24e-0532303MP:0005132
DomainSEA

MUC16 MUC17 MUC3A

3.51e-0614413SM00200
DomainSEA

MUC16 MUC17 MUC3A

1.69e-0523413PS50024
DomainSEA_dom

MUC16 MUC17 MUC3A

1.69e-0523413IPR000082
DomainCUT

ONECUT2 ONECUT1

9.81e-057412PF02376
DomainCUT_dom

ONECUT2 ONECUT1

9.81e-057412IPR003350
DomainCUT

ONECUT2 ONECUT1

9.81e-057412SM01109
DomainCUT

ONECUT2 ONECUT1

9.81e-057412PS51042
Domain-

MUC16 MUC17

4.85e-04154123.30.70.960
DomainSEA

MUC16 MUC17

1.06e-0322412PF01390
Domain-

ONECUT2 ONECUT1

1.59e-03274121.10.260.40
DomainLambda_DNA-bd_dom

ONECUT2 ONECUT1

1.84e-0329412IPR010982
PathwayREACTOME_DEFECTIVE_GALNT3_CAUSES_HFTC

MUC16 MUC17 MUC3A

4.78e-0616303M27410
PathwayREACTOME_DEFECTIVE_C1GALT1C1_CAUSES_TNPS

MUC16 MUC17 MUC3A

5.80e-0617303M27412
PathwayREACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS

MUC16 MUC17 MUC3A GALNT16

8.53e-0662304M546
PathwayREACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS

MUC16 MUC17 MUC3A

1.50e-0523303M556
PathwayREACTOME_DECTIN_2_FAMILY

MUC16 MUC17 MUC3A

2.19e-0526303M27483
PathwayREACTOME_O_LINKED_GLYCOSYLATION

MUC16 MUC17 MUC3A GALNT16

8.52e-05111304M27416
PathwayREACTOME_C_TYPE_LECTIN_RECEPTORS_CLRS

MUC16 MUC17 MUC3A ICAM3

2.09e-04140304M27484
PathwayREACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS

MUC16 MUC17 GALNT16

2.74e-0460303MM15636
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

MUC16 MUC17 MUC3A

3.97e-0468303M27303
PathwayREACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS

MUC16 MUC17

8.97e-0421302MM15706
Pubmed

Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux.

MUC16 MUC17 MUC3A

1.32e-061842318834073
Pubmed

Dose-dependent regulation of horizontal cell fate by Onecut family of transcription factors.

ONECUT2 ONECUT1

1.42e-06242232790713
Pubmed

Up-regulation of transient receptor potential canonical 1 (TRPC1) following sarco(endo)plasmic reticulum Ca2+ ATPase 2 gene silencing promotes cell survival: a potential role for TRPC1 in Darier's disease.

ATP2A2 TRPC1

1.42e-06242216899508
Pubmed

Combination Therapy with STAT3 Inhibitor Enhances SERCA2a-Induced BMPR2 Expression and Inhibits Pulmonary Arterial Hypertension.

BMPR2 ATP2A2

1.42e-06242234502015
Pubmed

OC-3, a novel mammalian member of the ONECUT class of transcription factors.

ONECUT2 ONECUT1

4.27e-06342211944891
Pubmed

ONECUT transcription factors induce neuronal characteristics and remodel chromatin accessibility.

ONECUT2 ONECUT1

4.27e-06342231049588
Pubmed

OC-2, a novel mammalian member of the ONECUT class of homeodomain transcription factors whose function in liver partially overlaps with that of hepatocyte nuclear factor-6.

ONECUT2 ONECUT1

4.27e-0634229915796
Pubmed

Genomic organization and structure of the 3' region of human MUC3: alternative splicing predicts membrane-bound and soluble forms of the mucin.

MUC17 MUC3A

4.27e-06342210512748
Pubmed

Cloning and embryonic expression pattern of the mouse Onecut transcription factor OC-2.

ONECUT2 ONECUT1

8.53e-06442212971999
Pubmed

Expression of the alpha7 isoform of hepatocyte nuclear factor (HNF) 4 is activated by HNF6/OC-2 and HNF1 and repressed by HNF4alpha1 in the liver.

ONECUT2 ONECUT1

8.53e-06442215159395
Pubmed

SERCA2b and 3 play a regulatory role in store-operated calcium entry in human platelets.

ATP2A2 TRPC1

8.53e-06442218068335
Pubmed

The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor.

CACNA1A ONECUT2 ARID1B

8.71e-063342319336002
Pubmed

Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.

CACNA1A ATP2A2 TRPC1

1.34e-053842330786075
Pubmed

Quantitation of HERV-K env gene expression and splicing in human breast cancer.

ERVK-6 ERVK-21

1.42e-05542212629516
Pubmed

MiR-495 and miR-218 regulate the expression of the Onecut transcription factors HNF-6 and OC-2.

ONECUT2 ONECUT1

1.42e-05542219913497
Pubmed

Otx2 and Onecut1 promote the fates of cone photoreceptors and horizontal cells and repress rod photoreceptors.

ONECUT2 ONECUT1

2.13e-05642223867227
Pubmed

The Onecut transcription factor HNF-6 (OC-1) is required for timely specification of the pancreas and acts upstream of Pdx-1 in the specification cascade.

ONECUT2 ONECUT1

2.13e-05642212781686
Pubmed

The transcription factor hepatocyte nuclear factor-6/Onecut-1 controls the expression of its paralog Onecut-3 in developing mouse endoderm.

ONECUT2 ONECUT1

2.13e-05642215381696
Pubmed

Onecut 1 and Onecut 2 are potential regulators of mouse retinal development.

ONECUT2 ONECUT1

3.97e-05842221830221
Pubmed

A CpG mutational hotspot in a ONECUT binding site accounts for the prevalent variant of hemophilia B Leyden.

ONECUT2 ONECUT1

3.97e-05842223472758
Pubmed

Hippo Signaling Mediators Yap and Taz Are Required in the Epicardium for Coronary Vasculature Development.

TBX18 LATS1

5.10e-05942227160901
Pubmed

Onecut Factors and Pou2f2 Regulate the Distribution of V2 Interneurons in the Mouse Developing Spinal Cord.

ONECUT2 ONECUT1

6.37e-051042231231191
Pubmed

Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.

ERVK-6 ERVK-21

6.37e-051042212970426
Pubmed

Interaction network of human early embryonic transcription factors.

NCOR1 NOL4 ARID1B ZMYM4 PRRC2B

6.37e-0535142538297188
Pubmed

Pou2f2 Regulates the Distribution of Dorsal Interneurons in the Mouse Developing Spinal Cord.

ONECUT2 ONECUT1

7.78e-051142231787878
Pubmed

Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.

ERVK-6 ERVK-21

9.32e-051242214557543
Pubmed

Renshaw cell interneuron specialization is controlled by a temporally restricted transcription factor program.

ONECUT2 ONECUT1

1.10e-041342222115757
Pubmed

Onecut transcription factors are required for the second phase of development of the A13 dopaminergic nucleus in the mouse.

ONECUT2 ONECUT1

1.10e-041342222102297
Pubmed

The Onecut transcription factors HNF-6/OC-1 and OC-2 regulate early liver expansion by controlling hepatoblast migration.

ONECUT2 ONECUT1

1.28e-041442217936262
Pubmed

Control of liver cell fate decision by a gradient of TGF beta signaling modulated by Onecut transcription factors.

ONECUT2 ONECUT1

1.28e-041442216103213
Pubmed

Onecut factors control development of the Locus Coeruleus and of the mesencephalic trigeminal nucleus.

ONECUT2 ONECUT1

1.28e-041442222534286
Pubmed

Genome wide expression profiling of the mesodiencephalic region identifies novel factors involved in early and late dopaminergic development.

ONECUT2 ONECUT1

1.28e-041442223213462
Pubmed

Dynamic expression of the Onecut transcription factors HNF-6, OC-2 and OC-3 during spinal motor neuron development.

ONECUT2 ONECUT1

1.69e-041642219800948
Pubmed

The Onecut Transcription Factors Regulate Differentiation and Distribution of Dorsal Interneurons during Spinal Cord Development.

ONECUT2 ONECUT1

1.69e-041642228603487
Pubmed

Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta.

HIVEP3 ONECUT2 PRRC2B

1.79e-049042315033168
Pubmed

The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse.

ONECUT2 ONECUT1

1.91e-041742216472605
Pubmed

Dynamic regulation of sarcoplasmic reticulum Ca(2+) stores by stromal interaction molecule 1 and sarcolipin during muscle differentiation.

ATP2A2 TRPC1

1.91e-041742222411552
Pubmed

Onecut-dependent Nkx6.2 transcription factor expression is required for proper formation and activity of spinal locomotor circuits.

ONECUT2 ONECUT1

2.15e-041842231969659
Pubmed

Onecut1 and Onecut2 transcription factors operate downstream of Pax6 to regulate horizontal cell development.

ONECUT2 ONECUT1

2.15e-041842225794677
Pubmed

Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.

NCOR1 ARID1B DTX2 RBMS2 PRRC2B

2.18e-0445742532344865
Pubmed

Onecut1 is essential for horizontal cell genesis and retinal integrity.

ONECUT2 ONECUT1

2.95e-042142223926259
Pubmed

Onecut transcription factors act upstream of Isl1 to regulate spinal motoneuron diversification.

ONECUT2 ONECUT1

2.95e-042142222833130
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

ZC3H10 CCNT2 NCOR1 ARID1B ATP2A2 ZMYM4 PRRC2B

3.24e-04110342734189442
Pubmed

Role of the Onecut transcription factors in pancreas morphogenesis and in pancreatic and enteric endocrine differentiation.

ONECUT2 ONECUT1

3.24e-042242217400205
Pubmed

Embryonic temporal-spatial delineation of excitatory spinal V3 interneuron diversity.

ONECUT2 ONECUT1

3.24e-042242238160393
Pubmed

Transcription factor Glis3, a novel critical player in the regulation of pancreatic beta-cell development and insulin gene expression.

ONECUT2 ONECUT1

3.54e-042342219805515
Pubmed

BCOR modulates transcriptional activity of a subset of glucocorticoid receptor target genes involved in cell growth and mobility.

NCOR1 PRRC2B

3.86e-042442233722704
Pubmed

Distinct roles of androgen receptor, estrogen receptor alpha, and BCL6 in the establishment of sex-biased DNA methylation in mouse liver.

GHR ONECUT1

3.86e-042442234215813
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

HIVEP3 ONECUT2 ZC3H10 NCOR1 CLOCK ONECUT1

3.97e-0480842620412781
Pubmed

A single-cell time-lapse of mouse prenatal development from gastrula to birth.

MUC16 TBX18

4.20e-042542238355799
Pubmed

Vsx1 Transiently Defines an Early Intermediate V2 Interneuron Precursor Compartment in the Mouse Developing Spinal Cord.

ONECUT2 ONECUT1

4.54e-042642228082864
Pubmed

Notch signaling controls liver development by regulating biliary differentiation.

ONECUT2 ONECUT1

4.54e-042642219369401
Pubmed

Onecut1 and Onecut2 play critical roles in the development of the mouse retina.

ONECUT2 ONECUT1

4.90e-042742225313862
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

NCOR1 ARID1B LATS1 ZMYM4 PRRC2B

5.06e-0454942538280479
Pubmed

Retrograde BMP signaling regulates trigeminal sensory neuron identities and the formation of precise face maps.

ONECUT2 ONECUT1

5.28e-042842217698011
Pubmed

Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

EHBP1 ARPP21 LATS1

5.63e-0413342315144186
Pubmed

LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development.

LATS1 ONECUT1

5.66e-042942227358050
Pubmed

Stabilization of beta-catenin affects mouse embryonic liver growth and hepatoblast fate.

ONECUT2 ONECUT1

5.66e-042942218038450
Pubmed

Tbx3 controls the fate of hepatic progenitor cells in liver development by suppressing p19ARF expression.

TBX18 ONECUT1

7.34e-043342218356246
Pubmed

A cellular and molecular mosaic establishes growth and differentiation states for cranial sensory neurons.

ONECUT2 ONECUT1

8.26e-043542226988119
Pubmed

Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry.

BMPR2 TRPC1

8.26e-043542215188402
Pubmed

Galnt1 is required for normal heart valve development and cardiac function.

BMPR2 GALNT16

8.74e-043642225615642
Pubmed

Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.

NCOR1 ATP2A2 ZMYM4 PRRC2B

8.98e-0435742437059091
Pubmed

Mesenchymal FGFR1 and FGFR2 control patterning of the ureteric mesenchyme by balancing SHH and BMP4 signaling.

TBX18 BMPR2

9.23e-043742236094016
Pubmed

SR protein kinases promote splicing of nonconsensus introns.

GHR DENND4A ZMYM4 PRRC2B

9.36e-0436142426167880
Pubmed

PITX2c is expressed in the adult left atrium, and reducing Pitx2c expression promotes atrial fibrillation inducibility and complex changes in gene expression.

ARPP21 TRPC1

1.13e-034142221282332
Pubmed

Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.

GHR MUC16 NCOR1

1.15e-0317042319064572
InteractionALG13 interactions

ZC3H10 NCOR1 DAZL ARID1B LATS1 TRIM52 RBMS2 PRRC2B

1.92e-09183398int:ALG13
InteractionR3HDM1 interactions

DAZL DTX2 LATS1 PRRC2B

2.07e-0584394int:R3HDM1
InteractionKDM5B interactions

CACNA1A ONECUT2 NCOR1 ARID1B

4.11e-05100394int:KDM5B
InteractionTBR1 interactions

NCOR1 ARID1B LATS1 ZMYM4

6.62e-05113394int:TBR1
InteractionEYA2 interactions

NCOR1 ARID1B DTX2 PRRC2B

8.64e-05121394int:EYA2
Cytoband6q25.1

ARID1B LATS1

5.63e-04384226q25.1
GeneFamilyCD molecules|Mucins

MUC16 MUC17 MUC3A

5.37e-0621303648
GeneFamilyCUT class homeoboxes and pseudogenes

ONECUT2 ONECUT1

9.51e-059302527
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CACNA1A MUC16 ARPP21 MUC3A GALNT16

8.45e-07195405d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CACNA1A MUC16 ARPP21 MUC3A GALNT16

8.45e-0719540519853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCellGlobus_pallidus-Neuronal-Excitatory|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

DAZL ARPP21 MUC3A PLK5

1.27e-05160404f843287ed57d2d5a3b3f6dfb03b6934e330e6645
ToppCellGlobus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

DAZL ARPP21 MUC3A PLK5

1.31e-05161404ebcd5066e82b7760b9da6adc02d11258d1309dab
ToppCellnucseq-Epithelial-Epithelial_Glandular|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MUC16 ONECUT2 MUC17 MUC3A

1.98e-05179404859cd8ee414ad6207c046ada2e655e49322dd01c
ToppCellnucseq-Epithelial-Epithelial_Glandular-Goblet|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MUC16 ONECUT2 MUC17 MUC3A

2.02e-051804043dc80bc636bf0e6ffc9762853132a9fe59fd1f66
ToppCellnucseq-Epithelial-Epithelial_Glandular-Goblet-Goblet|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MUC16 ONECUT2 MUC17 MUC3A

2.02e-05180404668a2d8e1d5a390309d5eb62c836f5903144bea9
ToppCellControl-Epithelial_cells-Airway_mucous|Control / group, cell type (main and fine annotations)

MUC16 ONECUT2 MUC17 MUC3A

2.16e-0518340415d24a4fb1ffe6cbafbd54fcd7dde9ddcfbe03b2
ToppCellfacs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GHR NOL4 SLITRK6 ATP2A2

2.55e-05191404f76f3f5c7902a3659d8cbe470f96ce57c8a6744d
ToppCelldroplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GHR NCOR1 ATP2A2 PRRC2B

2.60e-051924041304e69c92cef3bd8c82e3c035a7562f5440139a
ToppCelldroplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GHR NCOR1 ATP2A2 PRRC2B

2.71e-0519440492b39a935e8c577eb1123d706d168fa13cf3344c
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CACNA1A ONECUT2 NOL4 ARPP21

2.94e-051984048f25e8dff42bad8e779ca618bdb1cb1610667962
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_neuro-secretory|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CACNA1A ONECUT2 NOL4 ARPP21

2.94e-05198404e3e0aa3ef20b2370f5b133048510677aaa562dfa
DiseaseC-reactive protein measurement

ONECUT2 NCOR1 BMPR2 ARPP21 LATS1 SLITRK6 ONECUT1 RBMS2

1.25e-041206388EFO_0004458
Diseasepulmonary hypertension (is_implicated_in)

BMPR2 ATP2A2

6.87e-0430382DOID:6432 (is_implicated_in)
DiseaseBreast adenocarcinoma

NCOR1 ARID1B

1.28e-0341382C0858252
DiseaseNeoplasm of uncertain or unknown behavior of breast

NCOR1 ARID1B

1.28e-0341382C0496956
Diseasefrontal fibrosing alopecia

EHBP1 CACNA1A

1.75e-0348382EFO_0009855

Protein segments in the cluster

PeptideGeneStartEntry
PMPPYSSMFILSTTN

CACNA1A

1216

O00555
LSMLATGMPSTSYGL

CCNT2

331

O60583
PYMSSSASMQPITRP

ARID1B

1591

Q8NFD5
PNMGTSQSYLSSSMP

BBS10

581

Q8TAM1
TPVQSVMVSYPTMSS

ARPP21

711

Q9UBL0
PTMSSYQVPMTQGSQ

ARPP21

721

Q9UBL0
STLMSSPGSPVILQM

GALNT16

491

Q8N428
YMNNMSSPLTSRTPS

DENND4A

1211

Q7Z401
SYLMQPSGSVLTPGM

RBMS2

311

Q15434
ASTIPTEMMITTPYV

MUC16

10516

Q8WXI7
GTLMVMYVSPTSGNP

OR11H6

271

Q8NGC7
APSSYTNGSIPQSMM

LATS1

396

O95835
MAMAPSPSLVQVYTS

DTX2

1

Q86UW9
STKHSMPVPSMVPSY

KIF18A

806

Q8NI77
QMATLSPPFYSTNML

NEK10

721

Q6ZWH5
PTNTMTSMRTTTYWP

MUC3A

1016

Q02505
CETPPGMSMPTTYTT

ONECUT1

91

Q9UBC0
GMSMPTTYTTLTPLQ

ONECUT1

96

Q9UBC0
GMGMSNTYTTLTPLQ

ONECUT2

141

O95948
MYTVLTGTPPFMASP

PLK5

1

Q496M5
LTGVMETTMQPSPYP

IRGC

86

Q6NXR0
TYLPLTSMQPTEAMG

ICAM3

526

P32942
LSLSYTVMTPMLNPI

OR10A2

261

Q9H208
ESPYPMTMALSVLVT

ATP2A2

891

P16615
MMDPILTTSVPVYSL

GHR

206

P10912
TPSTGMTTISEMPYP

BMPR2

621

Q13873
TSSINMKQYASPMPT

EHBP1

116

Q8NDI1
PNTETYMQPTTTMNP

DAZL

146

Q92904
EGSTPLTYMPVSTML

MUC17

3161

Q685J3
SSTPSIPSVYTSMSM

MUC17

3771

Q685J3
MKQNPMTNYTTLPTS

SULT1C3

241

Q6IMI6
NNPSMPTQTSYLMVT

SLITRK6

571

Q9H5Y7
TQFPYNPLTMRMLSS

NCOR1

2381

O75376
PTLVTSMIDYNMPIT

NOL4

181

O94818
TPMTLSITSGMPNNF

OMG

376

P23515
PSTMLMGQVVTAYPT

CLOCK

726

O15516
MYTTSSILGPLQISM

TRPC1

516

P48995
MAGYATTPSPMQTLQ

TRIM52

1

Q96A61
GMSPQLQYIMPSPSS

TBX18

491

O95935
QAMSSLLSSPYSMPP

HIVEP3

1166

Q5T1R4
MPAPSYSPTSQKIMT

ERVK-6

106

Q9Y6I0
SQVYMHPSLSPPSTM

PRRC2B

1996

Q5JSZ5
PMVTYPIASQSMRIT

ZC3H10

416

Q96K80
MPTPLYSPTSQKIMT

ERVK-21

106

P63119
TPTLDSMSYGMPNQT

ZMYM4

46

Q5VZL5