Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	unmethylated CpG binding	KMT2B TLR9 KMT2A KDM2A	5.72e-07	10	147	4	GO:0045322
GeneOntologyMolecularFunction	intracellularly ligand-gated monoatomic ion channel activity	HCN4 HCN1 RYR1 RYR2	9.77e-05	33	147	4	GO:0005217
GeneOntologyMolecularFunction	ryanodine-sensitive calcium-release channel activity	RYR1 RYR2	3.20e-04	4	147	2	GO:0005219
GeneOntologyMolecularFunction	beta-adrenergic receptor kinase activity	GRK5 GRK6	3.20e-04	4	147	2	GO:0047696
GeneOntologyCellularComponent	multi-pass translocon complex	NOMO1 NOMO2 NOMO3	2.72e-05	9	146	3	GO:0160064
GeneOntologyCellularComponent	MLL1/2 complex	KMT2B KAT8 KMT2A MCRS1	7.98e-05	33	146	4	GO:0044665
GeneOntologyCellularComponent	ER membrane insertion complex	NOMO1 NOMO2 NOMO3	1.15e-04	14	146	3	GO:0072379
GeneOntologyCellularComponent	nuclear periphery	ZNF326 MAP2 LBR RGS12 KAT8 SMARCD1 PSPC1	2.03e-04	171	146	7	GO:0034399
GeneOntologyCellularComponent	HCN channel complex	HCN4 HCN1	2.88e-04	4	146	2	GO:0098855
GeneOntologyCellularComponent	endoplasmic reticulum membrane	HLA-A MBOAT7 VPS13C SMPD4 ERMP1 LBR TLR9 TLR8 RYR1 RYR2 CYP2W1 NOMO1 MIA2 NOMO2 VPS13A OSBPL6 RNF145 MOGAT3 NOMO3 MX1	6.78e-04	1293	146	20	GO:0005789
GeneOntologyCellularComponent	leading edge membrane	MAP2 HCN1 PLXND1 EPB41L3 PIP5K1A ROBO2 PLCG1	6.97e-04	210	146	7	GO:0031256
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	HLA-A MBOAT7 VPS13C SMPD4 ERMP1 LBR TLR9 TLR8 RYR1 RYR2 CYP2W1 NOMO1 MIA2 NOMO2 VPS13A OSBPL6 RNF145 MOGAT3 NOMO3 MX1	7.18e-04	1299	146	20	GO:0098827
GeneOntologyCellularComponent	cell leading edge	MYH10 ABI3BP MAP2 INPP5E HCN1 PLXND1 EPB41L3 PIP5K1A ROBO2 PKN2 PLCG1	7.91e-04	500	146	11	GO:0031252
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	HLA-A MBOAT7 VPS13C SMPD4 ERMP1 LBR TLR9 TLR8 RYR1 RYR2 CYP2W1 NOMO1 MIA2 NOMO2 VPS13A OSBPL6 RNF145 MOGAT3 NOMO3 MX1	9.35e-04	1327	146	20	GO:0042175
GeneOntologyCellularComponent	perinuclear endoplasmic reticulum	KCND3 OSBPL6 MOGAT3	1.07e-03	29	146	3	GO:0097038
GeneOntologyCellularComponent	cation channel complex	HCN4 HCN1 TRPC6 RYR1 RYR2 KCNA3 KCND3	1.34e-03	235	146	7	GO:0034703
GeneOntologyCellularComponent	MLL1 complex	KAT8 KMT2A MCRS1	1.43e-03	32	146	3	GO:0071339
GeneOntologyCellularComponent	apical dendrite	MAP2 HCN1 RGS12	1.43e-03	32	146	3	GO:0097440
Domain	GOLGA6L	GOLGA6L4 GOLGA6L10 GOLGA6L19 GOLGA6L9	5.61e-08	6	148	4	IPR026737
Domain	DUF2012	NOMO1 NOMO2 NOMO3	1.94e-06	4	148	3	PF09430
Domain	DUF2012	NOMO1 NOMO2 NOMO3	1.94e-06	4	148	3	IPR019008
Domain	GOLGA2L5	GOLGA6L4 GOLGA6L10 GOLGA6L19 GOLGA6L9	1.06e-05	18	148	4	PF15070
Domain	Golgin_A	GOLGA6L4 GOLGA6L10 GOLGA6L19 GOLGA6L9	1.06e-05	18	148	4	IPR024858
Domain	Carb-bd-like_fold	NOMO1 NOMO2 NOMO3	2.65e-05	8	148	3	IPR013784
Domain	Ion_trans_dom	HCN4 HCN1 TRPC6 RYR1 RYR2 KCNA3 KCND3	3.45e-05	114	148	7	IPR005821
Domain	Ion_trans	HCN4 HCN1 TRPC6 RYR1 RYR2 KCNA3 KCND3	3.45e-05	114	148	7	PF00520
Domain	MeTrfase_trithorax	KMT2B KMT2A	6.24e-05	2	148	2	IPR016569
Domain	ZF_CXXC	KMT2B KMT2A KDM2A	7.68e-05	11	148	3	PS51058
Domain	Znf_CXXC	KMT2B KMT2A KDM2A	7.68e-05	11	148	3	IPR002857
Domain	zf-CXXC	KMT2B KMT2A KDM2A	7.68e-05	11	148	3	PF02008
Domain	CarboxyPept_regulatory_dom	NOMO1 NOMO2 NOMO3	1.32e-04	13	148	3	IPR014766
Domain	-	NOMO1 NOMO2 NOMO3	1.32e-04	13	148	3	2.60.40.1120
Domain	AAA	ABCA2 ABCA3 WRNIP1 AK9 ATAD2 CLPB FIGNL1	1.51e-04	144	148	7	SM00382
Domain	AAA+_ATPase	ABCA2 ABCA3 WRNIP1 AK9 ATAD2 CLPB FIGNL1	1.51e-04	144	148	7	IPR003593
Domain	Ryanodine_rcpt	RYR1 RYR2	1.86e-04	3	148	2	IPR003032
Domain	VPS13	VPS13C VPS13A	1.86e-04	3	148	2	IPR026847
Domain	Ryanrecept_TM4-6	RYR1 RYR2	1.86e-04	3	148	2	IPR009460
Domain	VPS13_mid_rpt	VPS13C VPS13A	1.86e-04	3	148	2	PF16910
Domain	VPS13	VPS13C VPS13A	1.86e-04	3	148	2	PF16908
Domain	RyR	RYR1 RYR2	1.86e-04	3	148	2	PF02026
Domain	VPS13_N2	VPS13C VPS13A	1.86e-04	3	148	2	IPR031646
Domain	VPS13_mid_rpt	VPS13C VPS13A	1.86e-04	3	148	2	IPR031642
Domain	RR_TM4-6	RYR1 RYR2	1.86e-04	3	148	2	PF06459
Domain	Ryan_recept	RYR1 RYR2	1.86e-04	3	148	2	IPR013333
Domain	CarboxyPept-like_regulatory	NOMO1 NOMO2 NOMO3	3.06e-04	17	148	3	IPR008969
Domain	Ion_trans_N	HCN4 HCN1	3.70e-04	4	148	2	IPR013621
Domain	SHR-BD	VPS13C VPS13A	3.70e-04	4	148	2	IPR009543
Domain	Ion_trans_N	HCN4 HCN1	3.70e-04	4	148	2	PF08412
Domain	VPS13_C	VPS13C VPS13A	3.70e-04	4	148	2	PF16909
Domain	VPS13_C	VPS13C VPS13A	3.70e-04	4	148	2	IPR031645
Domain	SHR-BD	VPS13C VPS13A	3.70e-04	4	148	2	PF06650
Domain	-	LENG9 UBASH3B	6.14e-04	5	148	2	3.90.1140.10
Domain	FYrich_C	KMT2B KMT2A	6.14e-04	5	148	2	IPR003889
Domain	FYrich_N	KMT2B KMT2A	6.14e-04	5	148	2	IPR003888
Domain	FYRC	KMT2B KMT2A	6.14e-04	5	148	2	SM00542
Domain	FYRN	KMT2B KMT2A	6.14e-04	5	148	2	SM00541
Domain	TSP_3	COMP THBS2	6.14e-04	5	148	2	PF02412
Domain	TSP3	COMP THBS2	6.14e-04	5	148	2	PS51234
Domain	TSP_CTER	COMP THBS2	6.14e-04	5	148	2	PS51236
Domain	Thrombospondin_3_rpt	COMP THBS2	6.14e-04	5	148	2	IPR017897
Domain	TSP_type-3_rpt	COMP THBS2	6.14e-04	5	148	2	IPR028974
Domain	Autophagy-rel_C	VPS13C VPS13A	6.14e-04	5	148	2	IPR015412
Domain	ATG_C	VPS13C VPS13A	6.14e-04	5	148	2	PF09333
Domain	-	COMP THBS2	6.14e-04	5	148	2	4.10.1080.10
Domain	FYRN	KMT2B KMT2A	6.14e-04	5	148	2	PF05964
Domain	FYRC	KMT2B KMT2A	6.14e-04	5	148	2	PF05965
Domain	Thrombospondin_C	COMP THBS2	6.14e-04	5	148	2	IPR008859
Domain	FYRC	KMT2B KMT2A	6.14e-04	5	148	2	PS51543
Domain	FYRN	KMT2B KMT2A	6.14e-04	5	148	2	PS51542
Domain	TSP_C	COMP THBS2	6.14e-04	5	148	2	PF05735
Domain	Thrombospondin_3-like_rpt	COMP THBS2	6.14e-04	5	148	2	IPR003367
Domain	ATPase_AAA_core	WRNIP1 ATAD2 CLPB FIGNL1	8.80e-04	54	148	4	IPR003959
Domain	RIH_assoc-dom	RYR1 RYR2	9.16e-04	6	148	2	IPR013662
Domain	Ins145_P3_rec	RYR1 RYR2	9.16e-04	6	148	2	PF08709
Domain	RIH_assoc	RYR1 RYR2	9.16e-04	6	148	2	PF08454
Domain	RIH_dom	RYR1 RYR2	9.16e-04	6	148	2	IPR000699
Domain	Ins145_P3_rcpt	RYR1 RYR2	9.16e-04	6	148	2	IPR014821
Domain	Ryanodine_recept-rel	RYR1 RYR2	9.16e-04	6	148	2	IPR015925
Domain	-	RYR1 RYR2	9.16e-04	6	148	2	1.25.10.30
Domain	RYDR_ITPR	RYR1 RYR2	9.16e-04	6	148	2	PF01365
Domain	RNA_ligase/cNuc_Pdiesterase	LENG9 UBASH3B	9.16e-04	6	148	2	IPR009097
Domain	GPCR_kinase	GRK5 GRK6	1.28e-03	7	148	2	IPR000239
Domain	ATPase_AAA_CS	WRNIP1 ATAD2 FIGNL1	1.53e-03	29	148	3	IPR003960
Domain	Chorein_N	VPS13C VPS13A	1.69e-03	8	148	2	PF12624
Domain	Calx_beta	FREM3 FREM2	1.69e-03	8	148	2	SM00237
Domain	VPS13_N	VPS13C VPS13A	1.69e-03	8	148	2	IPR026854
Domain	Calx_beta	FREM3 FREM2	2.16e-03	9	148	2	IPR003644
Domain	Calx-beta	FREM3 FREM2	2.16e-03	9	148	2	PF03160
Domain	AAA	WRNIP1 ATAD2 FIGNL1	2.44e-03	34	148	3	PS00674
Domain	EF-hand_8	RYR1 RYR2 TNNC2	2.44e-03	34	148	3	PF13833
Domain	Cadherin	PCDHGC5 CDHR3 FAT3 FREM3 FREM2	2.49e-03	118	148	5	IPR002126
Domain	RGS	GRK5 GRK6 RGS12	2.65e-03	35	148	3	PF00615
Domain	RGS	GRK5 GRK6 RGS12	2.65e-03	35	148	3	SM00315
Domain	MIR	RYR1 RYR2	2.69e-03	10	148	2	PF02815
Domain	MIR_motif	RYR1 RYR2	2.69e-03	10	148	2	IPR016093
Domain	MIR	RYR1 RYR2	2.69e-03	10	148	2	PS50919
Domain	MIR	RYR1 RYR2	2.69e-03	10	148	2	SM00472
Domain	RGS	GRK5 GRK6 RGS12	2.87e-03	36	148	3	PS50132
Domain	Znf_PHD-finger	KMT2B DIDO1 KMT2A KDM2A	3.59e-03	79	148	4	IPR019787
Domain	RGS	GRK5 GRK6 RGS12	3.62e-03	39	148	3	IPR016137
Domain	ABC_A	ABCA2 ABCA3	3.91e-03	12	148	2	IPR026082
Domain	EGF_CA	COMP FAT3 THBS2 SUSD1	4.86e-03	86	148	4	PF07645
Domain	K_chnl_volt-dep_EAG/ELK/ERG	HCN4 HCN1	5.33e-03	14	148	2	IPR003938
Domain	PHD	KMT2B DIDO1 KMT2A KDM2A	5.49e-03	89	148	4	SM00249
Domain	Znf_PHD	KMT2B DIDO1 KMT2A KDM2A	5.94e-03	91	148	4	IPR001965
Domain	ZF_PHD_2	KMT2B DIDO1 KMT2A KDM2A	6.90e-03	95	148	4	PS50016
Domain	Post-SET_dom	KMT2B KMT2A	6.96e-03	16	148	2	IPR003616
Domain	PostSET	KMT2B KMT2A	6.96e-03	16	148	2	SM00508
Domain	cNMP-bd_CS	HCN4 HCN1	6.96e-03	16	148	2	IPR018488
Domain	POST_SET	KMT2B KMT2A	6.96e-03	16	148	2	PS50868
Domain	ZF_PHD_1	KMT2B DIDO1 KMT2A KDM2A	7.16e-03	96	148	4	PS01359
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	DOCK3 KMT2B HCN4 TLR9 EPB41L3 RYR1 TULP1 LIG3 MIA2 VPS13A SMARCD1 PLCG1 FOXH1	2.59e-09	329	152	13	17474147
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	CARM1 GLT6D1 KMT2B GRK5 GRK6 PLXND1 DPP8 CPNE5 MMP24 KCNA3 KCND3 KAT8 KMT2A PIP5K1A KDM2A TNNC2 PSPC1 WNK4	3.80e-09	730	152	18	34857952
Pubmed	Recurrent NOMO1 Gene Deletion Is a Potential Clinical Marker in Early-Onset Colorectal Cancer and Is Involved in the Regulation of Cell Migration.	NOMO1 NOMO2 NOMO3	8.18e-08	3	152	3	36011023
Pubmed	Silencing of nodal modulator 1 inhibits the differentiation of P19 cells into cardiomyocytes.	NOMO1 NOMO2 NOMO3	8.18e-08	3	152	3	25576386
Pubmed	Establishment of a conditional Nomo1 mouse model by CRISPR/Cas9 technology.	NOMO1 NOMO2 NOMO3	3.26e-07	4	152	3	31833031
Pubmed	A locus for autosomal recessive pseudoxanthoma elasticum, with penetrance of vascular symptoms in carriers, maps to chromosome 16p13.1.	NOMO1 NOMO2 NOMO3	3.26e-07	4	152	3	9267806
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	GPHN ZNF326 MAP2 INPP5E CC2D1A CBARP LBR DPP8 EPB41L3 LYST RGS12 FXR1 SH3PXD2A OSBPL6 KMT2A WNK4	1.30e-06	861	152	16	36931259
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	MRPS31 GGNBP2 MYH10 PCDHGC5 ABI3BP GRK5 GRK6 CAT PABPC5 RAD54L2 EPB41L3 LYST RYR2 FXR1 MIA2 SUSD1 SH3PXD2A VPS13A KMT2A TOP1MT PSPC1	1.37e-06	1442	152	21	35575683
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	DOCK3 ABCA2 KMT2B IMPDH1 INPP5E RNPEPL1 GRK5 GRK6 AOC2 CC2D1A PLXND1 PTCH1 LYST RYR1 ZGPAT MTHFR SUMF1 PLCG1	1.77e-06	1105	152	18	35748872
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	CARM1 HLA-A LYST NOMO1 PHKB CLPB NOMO2 SH3PXD2A SYK KMT2A BOP1 PKN2 PLCG1 UBASH3B NOMO3 KNL1	2.64e-06	910	152	16	36736316
Pubmed	TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk.	SYK PLCG1 UBASH3B	2.83e-06	7	152	3	27609517
Pubmed	Nicalin and its binding partner Nomo are novel Nodal signaling antagonists.	NOMO1 NOMO2 NOMO3	4.51e-06	8	152	3	15257293
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	GGNBP2 WDR64 MBOAT7 DCAF12L2 RYR1 RYR2 LIG3 VPS13A OTOP1 SMARCD1 MCRS1 NOMO3 KNL1	5.04e-06	638	152	13	31182584
Pubmed	WDFY4 is required for cross-presentation in response to viral and tumor antigens.	MYH10 HLA-A VPS13C NOMO1 NOMO2 SMARCD1 NOMO3	5.99e-06	156	152	7	30409884
Pubmed	Substrate-driven assembly of a translocon for multipass membrane proteins.	NOMO1 NOMO2 NOMO3	6.74e-06	9	152	3	36261522
Pubmed	INPP5E regulates phosphoinositide-dependent cilia transition zone function.	MAP2 INPP5E PTCH1	6.74e-06	9	152	3	27998989
Pubmed	Crosstalk between NSL histone acetyltransferase and MLL/SET complexes: NSL complex functions in promoting histone H3K4 di-methylation activity by MLL/SET complexes.	KAT8 KMT2A MCRS1	9.60e-06	10	152	3	24244196
Pubmed	DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.	KMT2B KMT2A KDM2A	9.60e-06	10	152	3	29276034
Pubmed	An ER translocon for multi-pass membrane protein biogenesis.	NOMO1 NOMO2 NOMO3	1.32e-05	11	152	3	32820719
Pubmed	Phospho-tyrosine dependent protein-protein interaction network.	KMT2B DOK7 WRNIP1 HESX1 DCAF12L1 MZF1 OSBPL6 SYK SMARCD1 TNNC2	1.41e-05	410	152	10	25814554
Pubmed	The small oligomerization domain of gephyrin converts MLL to an oncogene.	GPHN KMT2A	1.90e-05	2	152	2	14751928
Pubmed	Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors.	LIFR PLCG1	1.90e-05	2	152	2	7512571
Pubmed	Peripheral N- and C-terminal domains determine deactivation kinetics of HCN channels.	HCN4 HCN1	1.90e-05	2	152	2	17548059
Pubmed	Skeletal and cardiac ryanodine receptors exhibit different responses to Ca2+ overload and luminal ca2+.	RYR1 RYR2	1.90e-05	2	152	2	17259277
Pubmed	Small heat-shock protein HSPB3 promotes myogenesis by regulating the lamin B receptor.	HSPB3 LBR	1.90e-05	2	152	2	33958580
Pubmed	Ryanodine receptor oligomeric interaction: identification of a putative binding region.	RYR1 RYR2	1.90e-05	2	152	2	14722100
Pubmed	Association of p72syk with the src homology-2 (SH2) domains of PLC gamma 1 in B lymphocytes.	SYK PLCG1	1.90e-05	2	152	2	7744830
Pubmed	Structural and functional interactions within ryanodine receptor.	RYR1 RYR2	1.90e-05	2	152	2	26009179
Pubmed	Structure and Function of the Human Ryanodine Receptors and Their Association with Myopathies-Present State, Challenges, and Perspectives.	RYR1 RYR2	1.90e-05	2	152	2	32899693
Pubmed	Characterization of the MLL partner gene AF15q14 involved in t(11;15)(q23;q14).	KMT2A KNL1	1.90e-05	2	152	2	12618768
Pubmed	Phenotype/Genotype Relationship in Left Ventricular Noncompaction: Ion Channel Gene Mutations Are Associated With Preserved Left Ventricular Systolic Function and Biventricular Noncompaction: Phenotype/Genotype of Noncompaction.	HCN4 RYR2	1.90e-05	2	152	2	34088380
Pubmed	Toll-like receptor 8 and 9 polymorphisms in Crimean-Congo hemorrhagic fever.	TLR9 TLR8	1.90e-05	2	152	2	20674764
Pubmed	Ryanodine receptors in human pancreatic beta cells: localization and effects on insulin secretion.	RYR1 RYR2	1.90e-05	2	152	2	15033925
Pubmed	Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis.	MAP2 TLR8	1.90e-05	2	152	2	17060494
Pubmed	Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection.	GRK5 GRK6	1.90e-05	2	152	2	17786238
Pubmed	KMT2A and KMT2B Mediate Memory Function by Affecting Distinct Genomic Regions.	KMT2B KMT2A	1.90e-05	2	152	2	28723559
Pubmed	Association of TLR8 and TLR9 polymorphisms with tuberculosis in a Chinese Han population: a case-control study.	TLR9 TLR8	1.90e-05	2	152	2	30424735
Pubmed	Epigenetic high regulation of ATAD2 regulates the Hh pathway in human hepatocellular carcinoma.	PTCH1 ATAD2	1.90e-05	2	152	2	24805933
Pubmed	Colocalization of hyperpolarization-activated, cyclic nucleotide-gated channel subunits in rat retinal ganglion cells.	HCN4 HCN1	1.90e-05	2	152	2	21456027
Pubmed	Brain-specific transcript variants of 5' and 3' ends of mouse VPS13A and VPS13C.	VPS13C VPS13A	1.90e-05	2	152	2	17196930
Pubmed	Hyperpolarization-activated channels HCN1 and HCN4 mediate responses to sour stimuli.	HCN4 HCN1	1.90e-05	2	152	2	11675786
Pubmed	Role for the regulator of G-protein signaling homology domain of G protein-coupled receptor kinases 5 and 6 in beta 2-adrenergic receptor and rhodopsin phosphorylation.	GRK5 GRK6	1.90e-05	2	152	2	20038610
Pubmed	Repurposing Riociguat to Target a Novel Paracrine Nitric Oxide-TRPC6 Pathway to Prevent Podocyte Injury.	TRPC6 GUCY1A1	1.90e-05	2	152	2	34830371
Pubmed	Recent advances in understanding the ryanodine receptor calcium release channels and their role in calcium signalling.	RYR1 RYR2	1.90e-05	2	152	2	30542613
Pubmed	Ryanodine receptors are expressed and functionally active in mouse spermatogenic cells and their inhibition interferes with spermatogonial differentiation.	RYR1 RYR2	1.90e-05	2	152	2	15280431
Pubmed	Expression of the ryanodine receptor isoforms in immune cells.	RYR1 RYR2	1.90e-05	2	152	2	11673493
Pubmed	B-lymphocytes from malignant hyperthermia-susceptible patients have an increased sensitivity to skeletal muscle ryanodine receptor activators.	RYR1 RYR2	1.90e-05	2	152	2	11673462
Pubmed	Variants within the COMP and THBS2 genes are not associated with Achilles tendinopathy in a case-control study of South African and Australian populations.	COMP THBS2	1.90e-05	2	152	2	23875975
Pubmed	Molecular composition and functional properties of f-channels in murine embryonic stem cell-derived pacemaker cells.	HCN4 HCN1	1.90e-05	2	152	2	19135060
Pubmed	Crystal structures of wild type and disease mutant forms of the ryanodine receptor SPRY2 domain.	RYR1 RYR2	1.90e-05	2	152	2	25370123
Pubmed	Determination of the substrate specificity of protein-tyrosine phosphatase TULA-2 and identification of Syk as a TULA-2 substrate.	SYK UBASH3B	1.90e-05	2	152	2	20670933
Pubmed	Thermodynamics of calmodulin binding to cardiac and skeletal muscle ryanodine receptor ion channels.	RYR1 RYR2	1.90e-05	2	152	2	18618700
Pubmed	LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.	MYH10 CAT NOMO1 PHKB NOMO2 PLCG1 UBASH3B PSPC1 NOMO3	2.22e-05	344	152	9	30333137
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	MRPS31 HLA-A MAP2 MBOAT7 SMPD4 CC2D1A CBARP LBR DNAJB8 EPB41L3 NOMO1 LIFR CLPB NOMO2 VPS13A PIP5K1A BOP1 ERP29 PKN2	2.83e-05	1487	152	19	33957083
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	MRPS31 ZNF326 GGNBP2 KMT2B IMPDH1 MBOAT7 RBBP6 DIDO1 ERMP1 ATAD2 NOMO1 ZGPAT CLPB KAT8 CNOT7 KMT2A MCRS1 BOP1 PSPC1	3.10e-05	1497	152	19	31527615
Pubmed	Hyperpolarization-activated cyclic nucleotide-gated channels in olfactory sensory neurons regulate axon extension and glomerular formation.	HCN4 MAP2 HCN1	3.58e-05	15	152	3	21147989
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	MYH10 MBOAT7 WRNIP1 CCDC92 RAD54L2 NOMO1 FXR1 MCRS1 PSPC1 SRSF9 MX1	3.84e-05	560	152	11	21653829
Pubmed	Expression of Toll-like receptors in the developing brain.	MAP2 TLR9 TLR8	4.40e-05	16	152	3	22666391
Pubmed	Chromosomal mapping of the genes GPRK5 and GPRK6 encoding G protein-coupled receptor kinases GRK5 and GRK6.	GRK5 GRK6	5.68e-05	3	152	2	7789183
Pubmed	Dual or triple activation of TLR7, TLR8, and/or TLR9 by single-stranded oligoribonucleotides.	TLR9 TLR8	5.68e-05	3	152	2	22196370
Pubmed	Toll-like receptors as adjuvant receptors.	TLR9 TLR8	5.68e-05	3	152	2	11909637
Pubmed	Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.	RYR1 RYR2	5.68e-05	3	152	2	18403125
Pubmed	VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites.	VPS13C VPS13A	5.68e-05	3	152	2	30093493
Pubmed	G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway.	GRK5 GRK6	5.68e-05	3	152	2	19801552
Pubmed	Single nucleotide polymorphisms in genes encoding toll-like receptors 7, 8 and 9 in Danish patients with systemic lupus erythematosus.	TLR9 TLR8	5.68e-05	3	152	2	24919757
Pubmed	Ventricular HCN channels decrease the repolarization reserve in the hypertrophic heart.	HCN4 HCN1	5.68e-05	3	152	2	22652004
Pubmed	Toll-like receptor 7/8 (TLR7/8) and TLR9 agonists cooperate to enhance HIV-1 envelope antibody responses in rhesus macaques.	TLR9 TLR8	5.68e-05	3	152	2	24390332
Pubmed	Toll-like receptors 7, 8, and 9 expression and function in primary human cervical cancer Langerhans cells: evidence of anergy.	TLR9 TLR8	5.68e-05	3	152	2	23221735
Pubmed	Cytoplasmic cAMP-sensing domain of hyperpolarization-activated cation (HCN) channels uses two structurally distinct mechanisms to regulate voltage gating.	HCN4 HCN1	5.68e-05	3	152	2	21187420
Pubmed	Toll-like receptor 8-mediated activation of murine plasmacytoid dendritic cells by vaccinia viral DNA.	TLR9 TLR8	5.68e-05	3	152	2	20308556
Pubmed	The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.	RYR1 RYR2	5.68e-05	3	152	2	7876312
Pubmed	Dendritic differentiation of cerebellar Purkinje cells is promoted by ryanodine receptors expressed by Purkinje and granule cells.	RYR1 RYR2	5.68e-05	3	152	2	24123915
Pubmed	Novel insights into the distribution of cardiac HCN channels: an expression study in the mouse heart.	HCN4 HCN1	5.68e-05	3	152	2	21945247
Pubmed	TLR8 on dendritic cells and TLR9 on B cells restrain TLR7-mediated spontaneous autoimmunity in C57BL/6 mice.	TLR9 TLR8	5.68e-05	3	152	2	24474776
Pubmed	Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels.	HCN4 HCN1	5.68e-05	3	152	2	22006928
Pubmed	A t(11;15) fuses MLL to two different genes, AF15q14 and a novel gene MPFYVE on chromosome 15.	KMT2A KNL1	5.68e-05	3	152	2	12618766
Pubmed	Thrombospondin-1, -2 and -5 have differential effects on vascular smooth muscle cell physiology.	COMP THBS2	5.68e-05	3	152	2	26168731
Pubmed	Human and rhesus plasmacytoid dendritic cell and B-cell responses to Toll-like receptor stimulation.	TLR9 TLR8	5.68e-05	3	152	2	21977996
Pubmed	Phosphoprotein Phosphatase 1 Is Required for Extracellular Calcium-Induced Keratinocyte Differentiation.	PIP5K1A PLCG1	5.68e-05	3	152	2	27340655
Pubmed	Suppression of molecular inflammatory pathways by Toll-like receptor 7, 8, and 9 antagonists in a model of IL-23-induced skin inflammation.	TLR9 TLR8	5.68e-05	3	152	2	24386404
Pubmed	Dopamine D1 receptor signaling system regulates ryanodine receptor expression in ethanol physical dependence.	RYR1 RYR2	5.68e-05	3	152	2	23278119
Pubmed	Recognition of nucleic acid and nucleic acid analogs by Toll-like receptors 7, 8 and 9.	TLR9 TLR8	5.68e-05	3	152	2	18406377
Pubmed	Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.	RYR1 RYR2	5.68e-05	3	152	2	22948152
Pubmed	Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain.	RYR1 RYR2	5.68e-05	3	152	2	10788707
Pubmed	Spleen tyrosine kinase influences the early stages of multilineage differentiation of bone marrow stromal cell lines by regulating phospholipase C gamma activities.	SYK PLCG1	5.68e-05	3	152	2	28786489
Pubmed	Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor.	RYR1 RYR2	5.68e-05	3	152	2	7621815
Pubmed	TULA proteins regulate activity of the protein tyrosine kinase Syk.	SYK UBASH3B	5.68e-05	3	152	2	18189269
Pubmed	Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN).	GRK5 GRK6	5.68e-05	3	152	2	18662895
Pubmed	Association between toll-like receptor polymorphisms and systemic lupus erythematosus: a meta-analysis update.	TLR9 TLR8	5.68e-05	3	152	2	26762473
Pubmed	Molecular identification of the ryanodine receptor pore-forming segment.	RYR1 RYR2	5.68e-05	3	152	2	10473538
Pubmed	Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase.	TLR9 TLR8	5.68e-05	3	152	2	17932028
Pubmed	HCN channels in the mammalian cochlea: Expression pattern, subcellular location, and age-dependent changes.	HCN4 HCN1	5.68e-05	3	152	2	33181864
Pubmed	Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.	RYR1 RYR2	5.68e-05	3	152	2	18434746
Pubmed	Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice.	GRK5 GRK6	5.68e-05	3	152	2	12032308
Pubmed	Gene mutational analysis in a cohort of Chinese children with unexplained epilepsy: Identification of a new KCND3 phenotype and novel genes causing Dravet syndrome.	HCN1 KCND3	5.68e-05	3	152	2	30776697
Pubmed	SPRY domains in ryanodine receptors (Ca(2+)-release channels).	RYR1 RYR2	5.68e-05	3	152	2	9204703
Pubmed	Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.	RYR1 RYR2	5.68e-05	3	152	2	21881589
Pubmed	Endosomal toll-like receptor gene polymorphisms and susceptibility to HIV and HCV co-infection - Differential influence in individuals with distinct ethnic background.	TLR9 TLR8	5.68e-05	3	152	2	28062211
Pubmed	Sex differences in the response to viral infections: TLR8 and TLR9 ligand stimulation induce higher IL10 production in males.	TLR9 TLR8	5.68e-05	3	152	2	22768144
Pubmed	The functional effects of physical interactions among Toll-like receptors 7, 8, and 9.	TLR9 TLR8	5.68e-05	3	152	2	17040905
GeneFamily	Zinc fingers CXXC-type	KMT2B KMT2A KDM2A	3.28e-05	12	98	3	136
GeneFamily	Ryanodine receptors\|Protein phosphatase 1 regulatory subunits	RYR1 RYR2	8.69e-05	3	98	2	287
GeneFamily	AAA ATPases	WRNIP1 ATAD2 CLPB FIGNL1	1.94e-04	53	98	4	413
GeneFamily	Cyclic nucleotide gated channels	HCN4 HCN1	1.27e-03	10	98	2	250
GeneFamily	CD molecules\|Toll like receptors	TLR9 TLR8	1.27e-03	10	98	2	948
GeneFamily	PHD finger proteins	KMT2B DIDO1 KMT2A KDM2A	1.45e-03	90	98	4	88
GeneFamily	ATP binding cassette subfamily A	ABCA2 ABCA3	2.54e-03	14	98	2	805
GeneFamily	Cadherin related	CDHR3 FAT3	3.75e-03	17	98	2	24
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK3 MYH10 HSPB3 ABI3BP TRPC6 BCHE PTCH1 RYR2 FREM2 FNDC1 ROBO2	5.24e-11	188	152	11	293f2fa99f5f96aa7fd2b2a5cc94ff60eeaabe11
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_myofibroblast\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MYH10 COMP ABI3BP CDHR3 BCHE RYR2 THBS2 ROBO2 UBASH3B	2.69e-08	197	152	9	6d0d68d460243a0259ada93ebda40fa7b3088eeb
ToppCell	droplet-Kidney-KIDNEY-30m-Lymphocytic-Epcam____thick_ascending_tube_S_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CARM1 ANO9 RBM12B PTCH1 RGS12 PHKB FIGNL1 KNL1	1.93e-07	179	152	8	4166c4e1a8748a79ac6a11fd0b97c5344be2321b
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK3 ABI3BP FAT3 PTCH1 RYR2 FNDC1 ROBO2 UBASH3B	2.29e-07	183	152	8	7eae9b3b4d1c9b135fa7cff348393d4adec474b4
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ABI3BP FAT3 DOK7 CAT ERMP1 RGS12 FCGBP UBASH3B	2.29e-07	183	152	8	83592c332b1e82673f993d37c7f480befdc3dcda
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK3 HSPB3 ABI3BP FAT3 PTCH1 RYR2 FNDC1 THBS2	2.81e-07	188	152	8	3177b2c1723268d330d3e9f24f9e24492ace6286
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FAT3 TRPC6 CPNE5 RYR2 LIFR THBS2 SH3PXD2A ROBO2	3.17e-07	191	152	8	08720998aa55131d7377c4c67c4c935865bd7d79
ToppCell	IPF-Endothelial-VE_Arterial\|Endothelial / Disease state, Lineage and Cell class	CPAMD8 UPB1 ABI3BP MAP2 NOMO1 LIFR NOMO2 NOMO3	3.30e-07	192	152	8	e911e286da26202853f9650ba3cdefe5a5c9b585
ToppCell	Bronchial-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK3 FAT3 BCHE ITGA7 CPNE5 RYR2 FNDC1 MOGAT3	3.86e-07	196	152	8	9830fb3da7a60f65ad463e9054bb77c06b025e4d
ToppCell	Tracheal-10x5prime-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK3 ABCA3 HSPB3 FAT3 BCHE ITGA7 RYR2 FNDC1	4.16e-07	198	152	8	1e1ea54f0c234f3b6d29064c4881d8a0c0949a75
ToppCell	Fetal_29-31_weeks\|World / Lineage, Cell type, age group and donor	MYH10 FAT3 GRK5 RYR2 LIFR THBS2 SH3PXD2A ROBO2	4.33e-07	199	152	8	5b9d355795dd03a22f0961dfd143425c367a4654
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	DOCK3 MYH10 HSPB3 ABI3BP BCHE PTCH1 FNDC1 ROBO2	4.33e-07	199	152	8	e9820d5fb4e8b46973c4c50ac5db8fb4a1bf603b
ToppCell	distal-3-mesenchymal-Myofibroblast\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MYH10 COMP BCHE PTCH1 FNDC1 THBS2 GUCY1A1 ROBO2	4.33e-07	199	152	8	1f20addc0d138fec02ed6ca4c518169c568de263
ToppCell	distal-mesenchymal-Myofibroblast-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MYH10 COMP BCHE PTCH1 FNDC1 THBS2 GUCY1A1 ROBO2	4.49e-07	200	152	8	069c8949b33ecfdb6da32992002d4060ff6082bc
ToppCell	Control_saline-Mesenchymal_myocytic-Myofibroblastic\|Control_saline / Treatment groups by lineage, cell group, cell type	DOCK3 MYH10 HSPB3 ABI3BP PTCH1 RYR2 FNDC1 ROBO2	4.49e-07	200	152	8	9d5b3c2dcfa55d50acc2ce2c319d51aa525d4cd1
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	DOCK3 MYH10 HSPB3 ABI3BP BCHE PTCH1 FNDC1 ROBO2	4.49e-07	200	152	8	c596a53c0b63c9deaac7d99fcbdd94ecfa96b86c
ToppCell	distal-mesenchymal-Myofibroblast\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MYH10 COMP BCHE PTCH1 FNDC1 THBS2 GUCY1A1 ROBO2	4.49e-07	200	152	8	61854a459385cd9295be37157a8f81a2c227dff3
ToppCell	Adult-Mesenchymal-myofibroblast_cell-D122\|Adult / Lineage, Cell type, age group and donor	ABI3BP BCHE CBARP THBS2 ROBO2 TNNC2 UBASH3B	1.22e-06	158	152	7	410fa08c9d880d27e80ec939fa5ba5a41dcb31ab
ToppCell	Adult-Mesenchymal-vascular_smooth_muscle_cell-D231\|Adult / Lineage, Cell type, age group and donor	MYH10 UPB1 GRK5 TRPC6 ITGA7 RYR2 GUCY1A1	1.22e-06	158	152	7	8d64c0c9de910a3f4658778642d183c8b9b6f6a2
ToppCell	Adult-Mesenchymal-myofibroblast_cell\|Adult / Lineage, Cell type, age group and donor	ABI3BP BCHE CBARP PABPC5 THBS2 ROBO2 TNNC2	1.76e-06	167	152	7	d584a8548a5317bd9686b3be8246ae6ed568796b
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYH10 FNDC1 THBS2 SULF2 HOXD11 GUCY1A1 TTLL13	2.31e-06	174	152	7	9d22a554617a93701d0945de63cc3e7b24322c40
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ABI3BP FAT3 DOK7 ERMP1 RGS12 FCGBP UBASH3B	2.79e-06	179	152	7	55bc69f107fc710db7617c428575792adfdbbcc1
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DOCK3 ABI3BP BCHE PTCH1 FNDC1 GUCY1A1 ROBO2	3.00e-06	181	152	7	25915e2500430a902db37d79a749ce2990b69810
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK3 MYH10 ABI3BP TRPC6 PTCH1 FNDC1 ROBO2	3.47e-06	185	152	7	6712512100ccef456d2e2bd201d0987986c92ac9
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK3 MYH10 ABI3BP PTCH1 FNDC1 ROBO2 UBASH3B	3.47e-06	185	152	7	3b2dfc8f4c87be516265dbecfc251276034d0efd
ToppCell	Control\|World / Disease Group and Platelet Clusters	RBBP6 RNPEPL1 GRK6 CCDC92 CPNE5 MLH3 TNNC2	3.86e-06	188	152	7	f07654b215279abaf1c0882cdf41fbe31580a2ca
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK3 ABI3BP FAT3 PTCH1 RYR2 FNDC1 ROBO2	4.00e-06	189	152	7	45e588b2a4ad9e3ff74e22d9d627ed3571f3b8b8
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ABI3BP CAT ERMP1 RGS12 FCGBP GPC5 UBASH3B	4.14e-06	190	152	7	59bbbd2c8d4b7ce46c54ca8022b1557e7e5eee2a
ToppCell	ASK440-Mesenchymal\|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq	MYH10 COMP ABI3BP GRK5 FNDC1 THBS2 ROBO2	4.28e-06	191	152	7	f12959eebb4167e1aa03de05d7711a702c58b3c9
ToppCell	ASK440-Mesenchymal-Fibroblast\|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq	MYH10 COMP ABI3BP GRK5 FNDC1 THBS2 ROBO2	4.28e-06	191	152	7	387296b5377ef6839f0812e5b3529a10b5f7d530
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK3 HSPB3 ABI3BP PTCH1 RYR2 FNDC1 ROBO2	4.28e-06	191	152	7	b133ee1c0e58d00ddd2e4e05b01fd04947524c18
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell-D231\|Adult / Lineage, Cell type, age group and donor	MYH10 ABI3BP FAT3 TRPC6 RYR2 THBS2 ROBO2	4.59e-06	193	152	7	ef2f456c094e6e3c6ee81e0668c953cb8d0e1c0a
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MYH10 HSPB3 COMP BCHE FNDC1 THBS2 ROBO2	4.74e-06	194	152	7	8fae8061b350336299aa81f378e07deadbd55123
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MYH10 HSPB3 COMP BCHE FNDC1 THBS2 ROBO2	4.74e-06	194	152	7	4d7d24390fdb379f943ddcc70a63f23955e10163
ToppCell	COVID-19-Fibroblasts-Alveolar_FB\|COVID-19 / group, cell type (main and fine annotations)	MYH10 ABI3BP FAT3 TRPC6 RYR2 GUCY1A1 ROBO2	4.91e-06	195	152	7	603050beeb33c331d4b2e3fa46cae3f3e0e4bdc7
ToppCell	IPF-Stromal-Myofibroblast\|IPF / Disease state, Lineage and Cell class	MYH10 COMP ABI3BP RYR2 THBS2 GUCY1A1 ROBO2	5.07e-06	196	152	7	2d0a48e49b3b37bb66e33e74c52915911e1f8a74
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MYH10 HSPB3 COMP BCHE FNDC1 THBS2 ROBO2	5.25e-06	197	152	7	16758f181ef07c60aee63072e1da9572c5c85414
ToppCell	COVID-19-lung-Fibroblast\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MYH10 ABI3BP FAT3 TRPC6 RYR2 THBS2 ROBO2	5.42e-06	198	152	7	3ec01a55ade5e1627258cc3cfebb2c3207a4cb43
ToppCell	nucseq-Mesenchymal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MYH10 ABI3BP FAT3 TRPC6 RYR2 THBS2 ROBO2	5.42e-06	198	152	7	8f52243ca8b9ba68a75ae411506a3a6de258eb97
ToppCell	Fetal_29-31_weeks-Mesenchymal\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	MYH10 ABI3BP FAT3 RYR2 LIFR THBS2 ROBO2	5.42e-06	198	152	7	21cf4d81386761d09d0f6829c01c198e5524176d
ToppCell	Control-Control-Lymphocyte-T/NK-CD4+_T_activated\|Control / Disease, condition lineage and cell class	ANO9 MAP2 CDHR3 MMP24 SH3PXD2A PLCG1 MX1	5.42e-06	198	152	7	ee71543559836fd59adc0da877b2ca538cba60cb
ToppCell	Mesenchymal\|World / Lineage, Cell type, age group and donor	MYH10 ABI3BP FAT3 TRPC6 RYR2 THBS2 ROBO2	5.61e-06	199	152	7	4bac110c2b3609f6ee5d0e3275da0824a6240270
ToppCell	Bronchial-NucSeq-Stromal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MYH10 ABI3BP FAT3 TRPC6 RYR2 THBS2 ROBO2	5.79e-06	200	152	7	389cc775c8419d90fb77cd794376d2160a7bf44e
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	DOCK3 MYH10 HSPB3 ABI3BP PTCH1 FNDC1 ROBO2	5.79e-06	200	152	7	87827041663013f5e7273168dc8709d69840e7ce
ToppCell	Control_saline-Mesenchymal_myocytic\|Control_saline / Treatment groups by lineage, cell group, cell type	DOCK3 HSPB3 ABI3BP TRPC6 PTCH1 RYR2 FNDC1	5.79e-06	200	152	7	5ed4261157cd51109b314818133ac3a0d34ee5fa
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	DOCK3 MYH10 HSPB3 ABI3BP PTCH1 RYR2 FNDC1	5.79e-06	200	152	7	8988f113708eef7d9d2a6a6c1bcfd7c8f9804d3e
ToppCell	Parenchymal-NucSeq-Stromal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MYH10 ABI3BP FAT3 TRPC6 RYR2 THBS2 ROBO2	5.79e-06	200	152	7	cf433f9b43d7db07acaf70e060f8f77c974e72f3
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	DOCK3 MYH10 HSPB3 ABI3BP PTCH1 FNDC1 ROBO2	5.79e-06	200	152	7	08bf8c00eee6468215edb3611296bfc8784c4d56
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	MYH10 HSPB3 ABI3BP TRPC6 RYR2 FNDC1 ROBO2	5.79e-06	200	152	7	67dcbd86fbc79fd585d0793f979e4aac100326c9
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MYH10 ABI3BP FAT3 TRPC6 RYR2 THBS2 ROBO2	5.79e-06	200	152	7	cae972324d1dfea6efeaf6013f265c7c6bb48db4
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	HCN1 FAT3 RYR1 RYR2 ROBO2 GPC5	1.80e-05	159	152	6	5335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCell	Adult-Mesenchymal-chondrocyte\|Adult / Lineage, Cell type, age group and donor	MYH10 ABI3BP TRPC6 RYR2 THBS2 ROBO2	1.80e-05	159	152	6	3f7305ee76447064b5c846c4f576360a2f7e0b7c
ToppCell	AT1_cells-IPF_01\|World / lung cells shred on cell class, cell subclass, sample id	MAP2 GRK5 FREM3 MMP24 FNDC1 GPC5	2.00e-05	162	152	6	ae2ba4f21f6f6c512006fa531d670b88be7c04c9
ToppCell	COVID-19-kidney-Technical/muscle_(Imm)\|kidney / Disease (COVID-19 only), tissue and cell type	KLHL10 WDR64 HCN1 RYR1 RYR2 ROBO2	2.07e-05	163	152	6	19c28ce16a588a7f4a035c32726f6ccd67702b5b
ToppCell	facs-Marrow-B-cells-24m-Myeloid-granulocyte_monocyte_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABI3BP HCN1 PTCH1 RYR2 ROBO2 TTLL13	2.21e-05	165	152	6	6d315e0734079ad05336cc2c3f24d870c9105bc8
ToppCell	facs-Marrow-B-cells-24m-Myeloid-granulocyte_monocyte_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABI3BP HCN1 PTCH1 RYR2 ROBO2 TTLL13	2.21e-05	165	152	6	84f5597b1bb75f42de9a224196bb8ac198bbe3bf
ToppCell	P28-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	MAP2 WRNIP1 CC2D1A CCDC92 GPC5 TOP1MT	2.45e-05	168	152	6	8c8dbdbc7053f34e4ca0c5067af502fbea109fc1
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ABI3BP CAT ERMP1 RGS12 FCGBP UBASH3B	2.62e-05	170	152	6	5d5f208682be21ed58320f5fc083a7898f8712da
ToppCell	PND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T-CD8_T_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MBOAT7 LBR AGBL5 SUSD1 FIGNL1 KNL1	2.62e-05	170	152	6	a0d6466e00bd3dc07f644ba3f87d5b421fd479d5
ToppCell	droplet-Marrow-nan-3m-Myeloid-monocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VPS13C LYST TLR8 SULF2 MIA2 MX1	2.71e-05	171	152	6	992df143d76f9e7fb1997a8996f61e941f0f9d4f
ToppCell	Adult-Mesenchymal-vascular_smooth_muscle_cell\|Adult / Lineage, Cell type, age group and donor	MYH10 GRK5 TRPC6 ITGA7 RYR2 GUCY1A1	2.80e-05	172	152	6	c62cad0f4212d1e9ea1ec3143ad3c4e06aff0ebf
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MYH10 COMP ABI3BP BCHE THBS2 ROBO2	3.08e-05	175	152	6	1799a7be623dc3bf53ba580a7c47d2619969d708
ToppCell	droplet-Heart-nan-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VPS13C LYST TLR8 RYR2 GUCY1A1 PKN2	3.18e-05	176	152	6	749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCell	AT1_cells-HP_01\|World / lung cells shred on cell class, cell subclass, sample id	ABI3BP MAP2 GRK5 DOK7 FREM3 MMP24	3.18e-05	176	152	6	458720776b0151cd55acc352d509599cb62f0ca8
ToppCell	droplet-Lung-nan-3m-Myeloid-Proliferating_Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COMP SPINT1 ERMP1 CPNE5 SULF2 FIGNL1	3.39e-05	178	152	6	de6cd81e6d58e7687386df163471bf1901b9c0aa
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Rectal_Adenocarcinoma-7\|TCGA-Colorectal / Sample_Type by Project: Shred V9	COMP DIDO1 PTCH1 FNDC1 THBS2 KDM2A	3.39e-05	178	152	6	edc76b8f15056ec1c9a1c61a048b6331a92592d6
ToppCell	5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COMP BCHE PTCH1 RYR2 THBS2 ROBO2	3.72e-05	181	152	6	b116c68393d8836bac080f81a8fcbeb52e0403e7
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MYH10 ABI3BP FAT3 TRPC6 RYR2 ROBO2	3.72e-05	181	152	6	9ede19228ba5c0668a9c06c915510b95585216ef
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DOCK3 BCHE RYR2 THBS2 ROBO2 UBASH3B	3.84e-05	182	152	6	ed6ae0fd8653f213fe29906a6a4e0729a62e1b75
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC2_(MADCAM1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANO9 ABCA3 WDR64 LIFR MMP24 SULF2	3.84e-05	182	152	6	f231e86524b628e6e11ac33d5c34be99d454a92a
ToppCell	COVID-19-Heart-CM_4\|COVID-19 / Disease (COVID-19 only), tissue and cell type	HSPB3 CPNE5 RYR2 KCND3 SH3PXD2A OSBPL6	3.95e-05	183	152	6	2902b6e8aa9a6f62bc1a792c971ab7f651a8e676
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive\|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK3 ABI3BP PELI2 RYR2 MTHFR SUMF1	4.08e-05	184	152	6	d2bf0135eb56bb410997dccea39c5ede88a0617f
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COMP ITGA7 RYR2 FNDC1 THBS2 TNNC2	4.08e-05	184	152	6	c9d7ec17cc5b7ba1b1e721ca392746e8f4a3d41f
ToppCell	human_hepatoblastoma-Hepatic_Stellate_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	MAP2 FAT3 TRPC6 PELI2 THBS2 GUCY1A1	4.33e-05	186	152	6	cb1fc4b9140666b43415e21c9b434dc9b144e9d0
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MAP2 GRK5 TRPC6 ITGA7 RYR2 GUCY1A1	4.46e-05	187	152	6	48bfdb3504c3fefe5db3abac4b790c369680ab4e
ToppCell	Control-Fibroblasts-Alveolar_FB\|Control / group, cell type (main and fine annotations)	MYH10 ABI3BP FAT3 TRPC6 RYR2 ROBO2	4.46e-05	187	152	6	92d468dde81125d51daf7abd4703741abe1ab91c
ToppCell	RV-07._Pericyte\|World / Chamber and Cluster_Paper	UPB1 MAP2 GRK5 CCDC92 PLXND1 GUCY1A1	4.46e-05	187	152	6	dc274d6bbda619a2c914d84e2b4069cfef1739d1
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DOCK3 BCHE PTCH1 THBS2 ROBO2 UBASH3B	4.46e-05	187	152	6	c104fbfef2d0bef64077ac721edf2379fd59d547
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MAP2 GRK5 TRPC6 ITGA7 RYR2 GUCY1A1	4.46e-05	187	152	6	958402fcc78f4c7a7d13d659d776f3817137975f
ToppCell	-Unknown-Endothelial-Myofibroblast\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MRPS31 DOCK3 ABI3BP LBR RYR2 KMT2A	4.60e-05	188	152	6	6468fa95ad0395395301115286f2d8c0df5d3882
ToppCell	-Unknown-Endothelial\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MRPS31 DOCK3 ABI3BP LBR RYR2 KMT2A	4.60e-05	188	152	6	7a81ac5c79c3eb26639b52d2b9fd5e7ef9798fd6
ToppCell	-Unknown\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MRPS31 DOCK3 ABI3BP LBR RYR2 KMT2A	4.60e-05	188	152	6	9cb718bfe1358c6fd842f096e228eb0abb9aefc6
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	MYH10 ABI3BP FAT3 GUCY1A1 ROBO2 PKN2	4.73e-05	189	152	6	203c80030df08ae112f9ae4043709f455d87ce89
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CAT ERMP1 RGS12 FCGBP GPC5 UBASH3B	4.87e-05	190	152	6	1cf023e3c6924d6a06f353d4b62444b6f2fee8a7
ToppCell	Mesenchymal-airway_smooth_muscle_cell\|World / Lineage, Cell type, age group and donor	DOCK3 MYH10 BCHE FNDC1 THBS2 ROBO2	4.87e-05	190	152	6	645e56b02edc3702c7db917b8ecd5eed0decaf71
ToppCell	10x5'v1-week_17-19-Mesenchymal_myocytic-stroma\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	AOC2 PTCH1 SLC2A10 LIFR FNDC1 ROBO2	4.87e-05	190	152	6	81f8f2cddf4c51b879f315260cd1fca80355a371
ToppCell	10x5'v1-week_17-19-Mesenchymal_myocytic-stroma-muscle\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	AOC2 PTCH1 SLC2A10 LIFR FNDC1 ROBO2	4.87e-05	190	152	6	20106e5213f6a7560554b8b4f84b23c5554ba975
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_pericyte_(14)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	MAP2 TRPC6 BCHE ITGA7 RYR2 GUCY1A1	4.87e-05	190	152	6	10125091ad648163777b02e9f0d5e8d7f17d44a5
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FAT3 ITGA7 FNDC1 THBS2 HOXD11 GUCY1A1	4.87e-05	190	152	6	70c86dd454afb21d4a85db56c5f369d4b342bc97
ToppCell	(5)_Fibroblasts-(5)_Fibroblast-C_(Myofibroblast)\|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)	MYH10 FAT3 LIFR GUCY1A1 ROBO2 PKN2	4.87e-05	190	152	6	71e112dfb8c3190fe0286b45a046ea789eb6a8db
ToppCell	PCW_13-14\|World / Celltypes from embryonic and fetal-stage human lung	ABI3BP FAT3 GRK5 LIFR GUCY1A1 ROBO2	4.87e-05	190	152	6	62a3ec1ae0829602b0569cc051210551644f1d46
ToppCell	Control-Fibroblasts\|Control / group, cell type (main and fine annotations)	MYH10 ABI3BP FAT3 RYR2 THBS2 ROBO2	4.87e-05	190	152	6	3a42a9b98d954685d38a741f44545898d0e3e9ce
ToppCell	10x5'v1-week_17-19-Mesenchymal_myocytic\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	AOC2 PTCH1 SLC2A10 LIFR FNDC1 ROBO2	4.87e-05	190	152	6	877b544decf302e0d41be23dffa1861f79c70914
ToppCell	Control-Stromal_mesenchymal\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK3 ABI3BP FAT3 PTCH1 RYR2 FNDC1	5.02e-05	191	152	6	14057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK3 ABI3BP TRPC6 ITGA7 RYR2 FNDC1	5.02e-05	191	152	6	08042952431ca1a6fd7dfc13f36eb28643979598
ToppCell	ASK454-Mesenchymal\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	MYH10 COMP ABI3BP TRPC6 RYR2 ROBO2	5.02e-05	191	152	6	e30ae7a12439f8a79820b13f03e822c1223fd0cb
ToppCell	COPD-Endothelial-VE_Arterial\|Endothelial / Disease state, Lineage and Cell class	CPAMD8 LYST NOMO1 LIFR NOMO2 NOMO3	5.02e-05	191	152	6	ef16ad1c1cd2c0c0377957398c98775b62a81754
ToppCell	ASK454-Mesenchymal-Fibroblast\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	MYH10 COMP ABI3BP TRPC6 RYR2 ROBO2	5.02e-05	191	152	6	1726add3f392a061536b7aff72ba84303f4a0b1f
ToppCell	human_hepatoblastoma-Hepatic_Stellate_cells\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	MAP2 FAT3 TRPC6 PELI2 THBS2 GUCY1A1	5.02e-05	191	152	6	78c3c2fdb68c3407f2436f90e1e6a780bbf8b79e
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MYH10 ABI3BP FAT3 TRPC6 RYR2 ROBO2	5.02e-05	191	152	6	6688cee34beee4f151ac17fccbc9c26a9aad72e1
Drug	DO 897/99; Down 200; 8.2uM; MCF7; HT_HG-U133A	GRK6 DIDO1 PLXND1 PHKB ZGPAT LIG3 MLH3 CLPB MZF1 SYK	7.66e-07	197	150	10	7462_DN
Drug	AC1L380G	RYR1 RYR2 TNNC2 MX1	6.50e-06	19	150	4	CID000084698
Drug	Tolbutamide [64-77-7]; Down 200; 14.8uM; MCF7; HT_HG-U133A	ABCA2 MAP2 INPP5E RAD54L2 PTCH1 VPS13A SYK SMARCD1 PLCG1	6.57e-06	197	150	9	3886_DN
Drug	Repaglinide [135062-02-1]; Up 200; 8.8uM; PC3; HT_HG-U133A	UPB1 ITGA7 RGS12 RYR1 LIFR HOXD11 KCND3 MTHFR SYK	6.84e-06	198	150	9	5862_UP
Disease	Colorectal Carcinoma	CPAMD8 ABCA3 MAP2 RNPEPL1 TLR9 LIFR LIG3 MLH3 KCND3 MTHFR VPS13A MCRS1 KDM2A FOXH1	1.10e-05	702	146	14	C0009402
Disease	Parkinson's disease 23 (implicated_via_orthology)	VPS13C VPS13A	2.43e-05	2	146	2	DOID:0060896 (implicated_via_orthology)
Disease	choreaacanthocytosis (implicated_via_orthology)	VPS13C VPS13A	2.43e-05	2	146	2	DOID:0050766 (implicated_via_orthology)
Disease	congenital myopathy 1A (implicated_via_orthology)	RYR1 RYR2	7.27e-05	3	146	2	DOID:3529 (implicated_via_orthology)
Disease	autosomal recessive spinocerebellar ataxia 4 (implicated_via_orthology)	VPS13C VPS13A	7.27e-05	3	146	2	DOID:0111611 (implicated_via_orthology)
Disease	malignant hyperthermia (implicated_via_orthology)	RYR1 RYR2	7.27e-05	3	146	2	DOID:8545 (implicated_via_orthology)
Disease	Cohen syndrome (implicated_via_orthology)	VPS13C VPS13A	7.27e-05	3	146	2	DOID:0111590 (implicated_via_orthology)
Disease	sick sinus syndrome (implicated_via_orthology)	HCN4 HCN1	7.27e-05	3	146	2	DOID:13884 (implicated_via_orthology)
Disease	atrial fibrillation	HCN4 CDHR3 CCDC92 SULF2 KCND3 SH3PXD2A MTHFR SYK PKN2	1.02e-04	371	146	9	EFO_0000275
Disease	potassium voltage-gated channel subfamily A member 10 measurement	BCHE APOA4	2.41e-04	5	146	2	EFO_0802888
Disease	Moyamoya disease (is_implicated_in)	HLA-A GUCY1A1	2.41e-04	5	146	2	DOID:13099 (is_implicated_in)
Disease	glycoprotein measurement	HLA-A GRK6 MIA2 PLCG1 UBASH3B	3.22e-04	119	146	5	EFO_0004555
Disease	Autistic Disorder	UPB1 HLA-A CAT HOXD11 MTHFR KAT8 ROBO2	3.34e-04	261	146	7	C0004352
Disease	serine/threonine-protein kinase ULK3 measurement	GRK6 BCHE	3.60e-04	6	146	2	EFO_0803065
Disease	hepatocyte growth factor activator measurement	DOK7 RGS12	5.02e-04	7	146	2	EFO_0008152
Disease	X-24328 measurement	HCN1 CPNE5	5.02e-04	7	146	2	EFO_0800873
Disease	angle-closure glaucoma (is_implicated_in)	CAT MTHFR	5.02e-04	7	146	2	DOID:13550 (is_implicated_in)
Disease	eating disorder	FXR1 SUMF1 ROBO2	5.30e-04	32	146	3	EFO_0005203
Disease	joint hypermobility measurement	ABI3BP FNDC1 THBS2	5.81e-04	33	146	3	EFO_0007905
Disease	cerebellar ataxia (implicated_via_orthology)	VPS13C VPS13A	6.68e-04	8	146	2	DOID:0050753 (implicated_via_orthology)
Disease	multiple sclerosis	CPAMD8 HLA-A CDHR3 APOA4 MTHFR SUMF1 SYK GPC5 ARHGAP27 UBASH3B	7.78e-04	594	146	10	MONDO_0005301
Disease	Seizures	HCN1 BCHE CAT CLPB MTHFR KAT8	7.80e-04	218	146	6	C0036572
Disease	visual perception measurement	DOCK3 CPAMD8 HLA-A TRPC6 SUMF1 KMT2A	8.77e-04	223	146	6	EFO_0009700
Disease	cutaneous leishmaniasis (is_marker_for)	CAT TLR9	1.07e-03	10	146	2	DOID:9111 (is_marker_for)
Disease	Human papillomavirus infectious disease (is_marker_for)	TLR9 MX1	1.07e-03	10	146	2	DOID:11166 (is_marker_for)
Disease	Holoprosencephaly sequence	PTCH1 FOXH1	1.07e-03	10	146	2	cv:C0079541
Disease	high density lipoprotein cholesterol measurement, multiple sclerosis	SYK UBASH3B	1.07e-03	10	146	2	EFO_0004612, MONDO_0005301
Disease	retinitis pigmentosa (is_implicated_in)	IMPDH1 CAT TULP1	1.10e-03	41	146	3	DOID:10584 (is_implicated_in)
Disease	Other specified cardiac arrhythmias	HCN4 KCND3	1.30e-03	11	146	2	C0348626
Disease	Nodal rhythm disorder	HCN4 KCND3	1.30e-03	11	146	2	C0264893
Disease	Ectopic rhythm	HCN4 KCND3	1.30e-03	11	146	2	C1399226
Disease	CARDIAC CONDUCTION DEFECT, NONSPECIFIC (disorder)	HCN4 KCND3	1.30e-03	11	146	2	C2748542
Disease	schizophrenia (is_marker_for)	MAP2 BCHE APOA4	1.35e-03	44	146	3	DOID:5419 (is_marker_for)
Disease	Major Depressive Disorder	ABI3BP MAP2 CC2D1A CAT FREM3 MTHFR	1.36e-03	243	146	6	C1269683
Disease	Pulmonary Thromboembolisms	CAT MTHFR	1.55e-03	12	146	2	C0524702
Disease	Pulmonary Embolism	CAT MTHFR	1.55e-03	12	146	2	C0034065
Disease	Congenital muscular dystrophy	ITGA7 RYR1	1.55e-03	12	146	2	cv:C0699743
Disease	neovascular inflammatory vitreoretinopathy (is_marker_for)	CAT APOA4	1.55e-03	12	146	2	DOID:9719 (is_marker_for)
Disease	Congenital myopathy (disorder)	RYR1 TNNC2	1.55e-03	12	146	2	C0270960
Disease	tRNA (guanine-N(7)-)-methyltransferase measurement	GRK6 BCHE	1.83e-03	13	146	2	EFO_0802162
Disease	Brugada Syndrome 1	HCN4 KCND3	1.83e-03	13	146	2	C4551804
Disease	Unipolar Depression	ABI3BP MAP2 CC2D1A CAT FREM3 MTHFR	1.88e-03	259	146	6	C0041696
Disease	diastolic blood pressure, systolic blood pressure	HCN4 HCN1 DOK7 GRK6 RGS12 RYR2 LIG3 THBS2 OSBPL6 ERP29	1.90e-03	670	146	10	EFO_0006335, EFO_0006336
Disease	forced expiratory volume	BCHE AK9 PTCH1 RYR2 SLC2A10 ZGPAT SH3PXD2A OSBPL6 BOP1 KDM2A GPC5	1.95e-03	789	146	11	EFO_0004314
Disease	hepatocellular carcinoma (is_implicated_in)	KMT2B CAT TLR9 MTHFR PLCG1	2.11e-03	181	146	5	DOID:684 (is_implicated_in)
Disease	chronic kidney disease (is_implicated_in)	TLR9 MTHFR	2.13e-03	14	146	2	DOID:784 (is_implicated_in)
Disease	diacylglycerol 38:4 measurement	MBOAT7 DOK7	2.13e-03	14	146	2	EFO_0020066
Disease	eating disorder, bipolar disorder	RYR2 FXR1	2.13e-03	14	146	2	EFO_0005203, MONDO_0004985
Disease	Huntington's disease (is_marker_for)	MAP2 BCHE APOA4	2.32e-03	53	146	3	DOID:12858 (is_marker_for)
Disease	breast cancer (is_marker_for)	KMT2B SPINT1 TLR9 KAT8 PLCG1	2.32e-03	185	146	5	DOID:1612 (is_marker_for)
Disease	P wave duration	HCN1 KCND3	2.45e-03	15	146	2	EFO_0005094
Disease	Alobar Holoprosencephaly	PTCH1 FOXH1	2.45e-03	15	146	2	C0431363
Disease	inherited metabolic disorder (is_implicated_in)	GPHN BCHE	2.45e-03	15	146	2	DOID:655 (is_implicated_in)
Disease	Sinus Node Dysfunction (disorder)	HCN4 KCND3	2.45e-03	15	146	2	C0428908
Disease	Leber congenital amaurosis	IMPDH1 TULP1	2.79e-03	16	146	2	cv:C0339527
Disease	Diabetic Angiopathies	THBS2 MTHFR	2.79e-03	16	146	2	C0011875
Disease	Microangiopathy, Diabetic	THBS2 MTHFR	2.79e-03	16	146	2	C0025945
Disease	Lobar Holoprosencephaly	PTCH1 FOXH1	2.79e-03	16	146	2	C0431362
Disease	Semilobar Holoprosencephaly	PTCH1 FOXH1	2.79e-03	16	146	2	C0751617
Disease	Hypertrophic Cardiomyopathy	RYR2 KAT8 TNNC2	2.86e-03	57	146	3	C0007194
Disease	alcohol use disorder (implicated_via_orthology)	GRK5 GRK6 RYR1 RYR2 SMARCD1	2.91e-03	195	146	5	DOID:1574 (implicated_via_orthology)
Disease	Holoprosencephaly	PTCH1 FOXH1	3.15e-03	17	146	2	C0079541
Disease	sexual dimorphism measurement	DOCK3 KMT2B INPP5E APOA4 CCDC92 RAD54L2 PTCH1 GOLGA6L4 TULP1 ZGPAT MMP24 KDM2A SRSF9	3.44e-03	1106	146	13	EFO_0021796
Disease	Feeding difficulties	KAT8 SMARCD1	3.53e-03	18	146	2	C0232466
Disease	kidney volume	PTCH1 HOXD11	3.53e-03	18	146	2	EFO_0600044
Disease	Tachycardia	BCHE RYR2	3.53e-03	18	146	2	C0039231
Disease	Tachyarrhythmia	BCHE RYR2	3.53e-03	18	146	2	C0080203
Disease	Congenital Fiber Type Disproportion	ITGA7 RYR1	3.53e-03	18	146	2	C0546264
Disease	Tourette syndrome, schizophrenia	GGNBP2 CCDC92	3.53e-03	18	146	2	EFO_0004895, MONDO_0005090
Disease	osteochondrodysplasia (is_implicated_in)	COMP LIFR	3.93e-03	19	146	2	DOID:2256 (is_implicated_in)
Disease	laryngeal squamous cell carcinoma (is_marker_for)	CAT PLCG1	3.93e-03	19	146	2	DOID:2876 (is_marker_for)
Disease	level of Sterol ester (27:1/20:3) in blood serum	DOK7 NOMO1	3.93e-03	19	146	2	OBA_2045199
Disease	diacylglycerol 38:3 measurement	MBOAT7 DOK7	3.93e-03	19	146	2	EFO_0020065
Disease	transient cerebral ischemia (implicated_via_orthology)	TRPC6 PLXND1 KMT2A	3.97e-03	64	146	3	DOID:224 (implicated_via_orthology)
Disease	attention deficit hyperactivity disorder (is_implicated_in)	DOCK3 MTHFR	4.36e-03	20	146	2	DOID:1094 (is_implicated_in)
Disease	cardiovascular system disease (is_implicated_in)	TLR9 MTHFR	4.80e-03	21	146	2	DOID:1287 (is_implicated_in)
Disease	level of Phosphatidylinositol (18:0_18:2) in blood serum	MBOAT7 DOK7	4.80e-03	21	146	2	OBA_2045156
Disease	glycine measurement	MAP2 GRK6 ERMP1 MTHFR	4.86e-03	137	146	4	EFO_0009767
Disease	breast size	VPS13C OSBPL6 GPC5	4.90e-03	69	146	3	EFO_0004884

Protein segments in the cluster

Peptide	Gene	Start	Entry
RAVPAYGRFIQERFE	BOP1	351	Q14137
FPSRYTVELFEQVGR	AGBL5	546	Q8NDL9
FIQYIARAGDAVAFP	CBARP	356	Q8N350
EFVFGLPLERRDNYT	BCHE	471	P06276
VRDPRGFAVKFYTED	CAT	126	P04040
RVRFYEGPELVADSN	COMP	696	P49747
PVFYLFRDGDFENPV	ERP29	116	P30040
ALLFGRRFDYRDPVF	CYP2W1	181	Q8TAV3
RVRGFPSEKDFEDYI	ABCA3	106	Q99758
FIRDYGEIFNVQLPD	ATAD2	911	Q6PL18
GFRRIIFEYQPLVDA	ASB6	6	Q9NWX5
VDFVRPDFLGTRQEF	RAD54L2	506	Q9Y4B4
FREQPVDEIRNYFGE	ANO9	171	A1A5B4
YTFRNPEDIFREFFG	DNAJB8	91	Q8NHS0
SDTDFRIYRDFGNIP	ERMP1	326	Q7Z2K6
DFFVRLGYEVVAPDL	ABHD8	196	Q96I13
GLPYLVNEDDVRVFF	RBM12B	161	Q8IXT5
VIPFYRGERITFDVA	NOMO3	291	P69849
YAVRAADGPGDRFII	GPHN	376	Q9NQX3
YDFFIGRELNPRIGT	LBR	366	Q14739
EEFRRRVEPYGENFN	APOA4	301	P06727
RVGFLLRPYNFFDED	AOC2	696	O75106
PARIDAAYERADGRF	MMP24	426	Q9Y5R2
VRPIAYIDFENAFRT	FIGNL1	636	Q6PIW4
VFEVFVLYLSGEPNR	MTHFR	431	P42898
VIPFYRGERITFDVA	NOMO2	291	Q5JPE7
NGIFLEYISFREPFR	OR10AD1	156	Q8NGE0
EYFFDRDPEVFRCVL	KCND3	81	Q9UK17
RQVQAVFPFFREDYE	FOXH1	61	O75593
GADELARYFPDRNVA	INPP5E	286	Q9NRR6
FRPAVYAGEVERRFP	NUDT14	61	O95848
GEEEFPFERRQIPLY	GGNBP2	11	Q9H3C7
YLFGADVNPEEFVNR	GPC5	151	P78333
SEIYPVEIRGRAFAF	SLC2A10	436	O95528
YDVENRPGFAAVELR	SYK	611	P43405
RGFLEFVEDFIQVPR	FXR1	276	P51114
EPFVFYILTEVDRQG	KAT8	281	Q9H7Z6
FDVTDGINPLIDRYF	FREM2	1396	Q5SZK8
FEGELRGYAVQRLPE	DCAF12L2	71	Q5VW00
LRGAAVDEYFRQPVV	CARM1	326	Q86X55
EIPVRYQEEFEARGL	HSPB3	11	Q12988
PVDFFINGRAYADEV	PLXND1	1136	Q9Y4D7
RLDPADFSVGYVDRF	LENG9	101	Q96B70
YVDRFLGVREEPFSA	LENG9	111	Q96B70
VQDLENPRFYGFRGE	MLH3	81	Q9UHC1
PEDGRIFAQRTFDYE	PCDHGC5	511	Q9Y5F6
VIPFYRGERITFDVA	NOMO1	291	Q15155
VFRVNCYPGIDIRED	HESX1	126	Q9UBX0
PIDIFSEEIRFYQLG	KCNA3	176	P22001
LAREDEFLYGRFPEG	LCT	1366	P09848
LFPLEAVREDAFYAR	MBOAT7	211	Q96N66
EESVVGFPFLDKRYR	KNL1	2161	Q8NG31
ALYEQRAEPRSGFEE	GOLGA6L3	436	A6NEY3
ALYEQRAEPRSGFEE	GOLGA6L4	461	A6NEF3
YEQRAEPRSGFEELN	GOLGA6L9	321	A6NEM1
YEQRAEPRSGFEELN	GOLGA6L10	411	A6NI86
EALYEQRAEPRSGFE	GOLGA6L19	436	H0YKK7
NPDGFDVLRRVYVDF	KMT2B	1696	Q9UMN6
RRYFVAFDGDLVQEF	LIG3	956	P49916
LQEVERFLAPYGRQD	GTPBP8	51	Q8N3Z3
YGFTRFAIELNELDP	OSBPL6	826	Q9BZF3
AFRYFRELFGIRPDD	PIP5K1A	146	Q99755
LRFEVFQPGDYIIRE	HCN4	611	Q9Y3Q4
INGLRRFEIEYQGDP	SMPD4	716	Q9NXE4
VPQGETEREYFNRYR	RBBP6	786	Q7Z6E9
AEYARRFGVPIIADG	IMPDH1	351	P20839
LVPVYSFGENDIFRL	MOGAT3	226	Q86VF5
YVGRFKFPEERAAEV	PABPC5	176	Q96DU9
RPEYDNGLEEIVFGF	OTOP1	566	Q7RTM1
VVARPIGEFRSNADY	CNOT7	46	Q9UIV1
LRFEVFQPGDYIIRE	HCN1	491	O60741
ANVEEYAARRDNFPG	KLHL10	576	Q6JEL2
DFNVEYIQRGGLRDP	KDM2A	61	Q9Y2K7
EQQRLEPEFFRVGFY	DOCK3	1346	Q8IZD9
VFATGRFAEEYLRPF	GLT6D1	81	Q7Z4J2
FDGDSFVRLRVPAAY	FCGBP	4591	Q9Y6R7
GYAFEAAEEQLRRPR	UPB1	56	Q9UBR1
PEFEEVYRFGAESRK	CCDC92	216	Q53HC0
ERANPGFIYQVEAFD	CDHR3	146	Q6ZTQ4
EFDLAGRKRFVAPYV	FNDC1	1601	Q4ZHG4
AGRRVLFYFDEIPSR	CPAMD8	1606	Q8IZJ3
QPFEILFEGVEYIAR	DPP8	366	Q6V1X1
RGEPIYRAFAFDRDE	FAT3	1271	Q8TDW7
QPVREVAFRDYGLER	HOXD11	56	P31277
GDLDVFVRFDFPYPN	CC2D1A	676	Q6P1N0
YDPERAFDTQLVERG	DIDO1	1391	Q9BTC0
RGNFIPYANEERREY	ABCA2	1501	Q9BZC7
RGEPRFIAVGYVDDT	HLA-A	41	P04439
PEFLVNREGFDFGVR	LYST	3301	Q99698
DFFIANEGRRPIYID	MCRS1	401	Q96EZ8
VPENGFEVFRRVFVD	KMT2A	1986	Q03164
FDGELRGYAVQRLPE	DCAF12L1	71	Q5VU92
DEFLGRINEIVYFLP	CLPB	556	Q9H078
LIVGAPYFFERQEEL	ITGA7	381	Q13683
DLRRYGAVPSGFIFE	DOK7	156	Q18PE1
PGFEEERALFYAAEI	GRK5	281	P34947
AGFPEARAVFYAAEI	GRK6	281	P43250
EFANRFQEPARDIGF	RYR1	4126	P21817
NPVEGERYLDFLRFA	RYR2	2291	Q92736
NFYIKIRPGEFEQFE	EPB41L3	346	Q9Y2J2
GLEDPERYLFVDRAV	MYH10	6	P35580
ERDIVQFVPFRDYVD	CPNE5	516	Q9HCH3
VFCVERVYRVPDFGV	PHKB	206	Q93100
IESDEFRPGIRYNFF	LIFR	686	P42702
KEFGYFPRDAVQIEE	MIA2	86	Q96PC5
FEFQVIGELYPVFRT	FREM3	1511	P0C091
RPELRIQFDEGYDNY	MRPS31	221	Q92665
FILDGFPRYPEEAQF	AK9	1121	Q5TCS8
CGDPQRFDDFLRAYV	RNPEPL1	456	Q9HAU8
LVPFAFVRFEDPRDA	SRSF9	51	Q13242
GNPEEERRAEFYFQP	SMARCD1	471	Q96GM5
DRNEPYTARIFAAGF	PELI2	146	Q9HAT8
PDDILLFRDRFDGYI	UPF3A	121	Q9H1J1
FYFRTDEAEPVGALL	PLEKHJ1	46	Q9NW61
EESRRVFFYNPLTGE	ARHGAP27	311	Q6ZUM4
VPRETREYDFIAAQF	PTCH1	781	Q13635
KDFRYGVEDFREVDP	SLC3A1	171	Q07837
FDSIVNDEVRYPRFL	PKN2	866	Q16513
DGEAPARRVTIDAFY	SUMF1	111	Q8NBK3
QPEVGLFFFLRDVVY	LINC01553	26	A4QN01
ADDPDYIVLQFGRVA	TULP1	496	O00294
GYVFQELREDDFQPL	TLR8	376	Q9NR97
FFNEDGVIRPYRLRD	VPS13A	3041	Q96RL7
FERLLQDPVGVRYFS	RGS12	716	O14924
LFERYGEPSEVFINR	PSPC1	101	Q8WXF1
FRAFPGLRYVDLSDN	TLR9	411	Q9NR96
EVFRFFEARPEDVNP	SH3PXD2A	116	Q5TCZ1
FAPREGFINYLTREV	SPINT1	131	O43278
QVRYACREGFFSVPE	SUSD1	201	Q6UWL2
VRFFVVDCRPAEQYN	TBC1D23	336	Q9NUY8
FFYEGRPVRLSVAAE	TOP1MT	76	Q969P6
RFYFDNREGVILPGE	MYCBPAP	481	Q8TBZ2
NPEFAFLRFVVYEED	PLCG1	1151	P19174
GDEVFRFQLTLYPDA	VPS13C	1666	Q709C8
YVRVDGSRLRQEDFP	ROBO2	16	Q9HCK4
LVRSANGFPYREDEE	MAP2	41	P11137
RIFDRNADGYIDPEE	TNNC2	101	P02585
DQEYLPEELRGVDFF	WRNIP1	646	Q96S55
TFGDGVLERRPYEDQ	UBASH3B	341	Q8TF42
RFLDAAEYGNIPVVR	TRPC6	101	Q9Y210
RFVRFDYIPPVNADD	THBS2	56	P35442
GYFRAVRQEPVQFGE	ABI3BP	1031	Q7Z7G0
EYIARRPDNQEGAFD	RNF145	631	Q96MT1
GEYREIPSERDFFQE	TXNDC9	71	O14530
YNEFILPSERDGFLR	WNK4	721	Q96J92
EFDIRVPFYVRGPNV	SULF2	336	Q8IWU5
PGRQEDAEYQAFREA	ZGPAT	71	Q8N5A5
RRYPLEGFVTENREA	WDR64	991	B1ANS9
DPLRIFTYEEGLARF	TTLL13	256	A6NNM8
RYERFVKGENPFEIQ	ZNF326	461	Q5BKZ1
RRDFQGKPNFEEYFE	GUCY1A1	311	Q02108
RGRELPGFVNYRTFE	MX1	441	P20591
EFFEGRQAKTPERYL	MYSM1	396	Q5VVJ2
RFRCFRYEEATGPQE	MZF1	46	P28698