Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	four-way junction helicase activity	RECQL5 WRN	1.43e-05	6	20	2	GO:0009378
GeneOntologyMolecularFunction	monosaccharide binding	MRC1 PLOD3 IGF2R	1.12e-04	95	20	3	GO:0048029
GeneOntologyMolecularFunction	3'-5' DNA helicase activity	RECQL5 WRN	1.13e-04	16	20	2	GO:0043138
GeneOntologyMolecularFunction	hydrolase activity, hydrolyzing O-glycosyl compounds	MGAM OVGP1 PARG	1.43e-04	103	20	3	GO:0004553
GeneOntologyMolecularFunction	carbohydrate binding	MRC1 MGAM PLOD3 IGF2R	2.27e-04	310	20	4	GO:0030246
GeneOntologyMolecularFunction	D-mannose binding	MRC1 IGF2R	3.30e-04	27	20	2	GO:0005537
GeneOntologyMolecularFunction	hydrolase activity, acting on glycosyl bonds	MGAM OVGP1 PARG	3.83e-04	144	20	3	GO:0016798
GeneOntologyMolecularFunction	DNA helicase activity	RECQL5 WRN	1.74e-03	62	20	2	GO:0003678
GeneOntologyMolecularFunction	organic acid binding	RYR2 PLOD3 IGF2R	1.98e-03	254	20	3	GO:0043177
GeneOntologyMolecularFunction	calcium ion binding	FLG NID2 RYR2 FLG2	5.89e-03	749	20	4	GO:0005509
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	RECQL5 WRN	7.07e-03	127	20	2	GO:0008094
GeneOntologyMolecularFunction	helicase activity	RECQL5 WRN	1.08e-02	158	20	2	GO:0004386
GeneOntologyBiologicalProcess	DNA unwinding involved in DNA replication	RECQL5 WRN	1.86e-04	21	20	2	GO:0006268
GeneOntologyBiologicalProcess	cellular response to alkaloid	RYR2 RECQL5	6.82e-04	40	20	2	GO:0071312
GeneOntologyBiologicalProcess	establishment of skin barrier	FLG FLG2	7.16e-04	41	20	2	GO:0061436
GeneOntologyBiologicalProcess	basement membrane organization	NID2 PLOD3	7.88e-04	43	20	2	GO:0071711
GeneOntologyBiologicalProcess	epidermis development	PTCH2 FLG PLOD3 FLG2	8.98e-04	461	20	4	GO:0008544
GeneOntologyBiologicalProcess	base-excision repair	PARG WRN	9.01e-04	46	20	2	GO:0006284
GeneOntologyBiologicalProcess	nuclear DNA replication	RECQL5 WRN	9.01e-04	46	20	2	GO:0033260
GeneOntologyBiologicalProcess	epidermis morphogenesis	PLOD3 FLG2	9.01e-04	46	20	2	GO:0048730
GeneOntologyBiologicalProcess	cell cycle DNA replication	RECQL5 WRN	1.11e-03	51	20	2	GO:0044786
GeneOntologyCellularComponent	keratohyalin granule	FLG FLG2	8.68e-06	5	20	2	GO:0036457
MousePheno	increased fetal weight	AMER1 IGF2R	1.61e-05	6	15	2	MP:0009432
MousePheno	increased fetal size	AMER1 IGF2R	3.85e-05	9	15	2	MP:0004199
MousePheno	abnormal extracellular matrix morphology	PLOD3 FBXW5 WRN	1.52e-04	100	15	3	MP:0013258
Domain	Filaggrin	FLG FLG2	1.09e-06	2	20	2	IPR003303
Domain	RecQ_Zn-bd	RECQL5 WRN	6.53e-06	4	20	2	IPR032284
Domain	RecQ_Zn_bind	RECQL5 WRN	6.53e-06	4	20	2	PF16124
Domain	DNA_helicase_ATP-dep_RecQ	RECQL5 WRN	1.09e-05	5	20	2	IPR004589
Domain	-	MRC1 IGF2R	8.44e-05	13	20	2	2.10.10.10
Domain	FN_type2_col-bd	MRC1 IGF2R	9.84e-05	14	20	2	IPR000562
Domain	FN2_2	MRC1 IGF2R	9.84e-05	14	20	2	PS51092
Domain	fn2	MRC1 IGF2R	9.84e-05	14	20	2	PF00040
Domain	FN2_1	MRC1 IGF2R	9.84e-05	14	20	2	PS00023
Domain	FN2	MRC1 IGF2R	9.84e-05	14	20	2	SM00059
Domain	S100_CABP	FLG FLG2	3.76e-04	27	20	2	PS00303
Domain	S_100	FLG FLG2	3.76e-04	27	20	2	PF01023
Domain	S100_Ca-bd_sub	FLG FLG2	4.05e-04	28	20	2	IPR013787
Domain	S100/CaBP-9k_CS	FLG FLG2	4.05e-04	28	20	2	IPR001751
Domain	S_100	FLG FLG2	4.05e-04	28	20	2	SM01394
Domain	Kringle-like	MRC1 IGF2R	5.30e-04	32	20	2	IPR013806
Domain	DEAH_ATP_HELICASE	RECQL5 WRN	7.48e-04	38	20	2	PS00690
Domain	Glycoside_hydrolase_SF	MGAM OVGP1	1.45e-03	53	20	2	IPR017853
Domain	EF_HAND_2	FLG RYR2 FLG2	1.82e-03	231	20	3	PS50222
Domain	EF_hand_dom	FLG RYR2 FLG2	1.84e-03	232	20	3	IPR002048
Domain	-	FLG RYR2 FLG2	2.58e-03	261	20	3	1.10.238.10
Domain	DEAD	RECQL5 WRN	2.74e-03	73	20	2	PF00270
Domain	DEAD/DEAH_box_helicase_dom	RECQL5 WRN	2.74e-03	73	20	2	IPR011545
Domain	EF-hand-dom_pair	FLG RYR2 FLG2	3.37e-03	287	20	3	IPR011992
Domain	Helicase_C	RECQL5 WRN	5.78e-03	107	20	2	PF00271
Domain	HELICc	RECQL5 WRN	5.78e-03	107	20	2	SM00490
Domain	Helicase_C	RECQL5 WRN	5.88e-03	108	20	2	IPR001650
Domain	HELICASE_CTER	RECQL5 WRN	5.99e-03	109	20	2	PS51194
Domain	HELICASE_ATP_BIND_1	RECQL5 WRN	5.99e-03	109	20	2	PS51192
Domain	DEXDc	RECQL5 WRN	5.99e-03	109	20	2	SM00487
Domain	Helicase_ATP-bd	RECQL5 WRN	6.09e-03	110	20	2	IPR014001
Pubmed	Expression of filaggrin-2 protein in the epidermis of human skin diseases: a comparative analysis with filaggrin.	FLG FLG2	3.14e-07	2	20	2	24813994
Pubmed	Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin.	FLG FLG2	9.42e-07	3	20	2	23403047
Pubmed	Filaggrin and filaggrin 2 processing are linked together through skin aspartic acid protease activation.	FLG FLG2	9.42e-07	3	20	2	32437351
Pubmed	GATA3 regulates FLG and FLG2 expression in human primary keratinocytes.	FLG FLG2	9.42e-07	3	20	2	28928464
Pubmed	Differential and Concordant Roles for Poly(ADP-Ribose) Polymerase 1 and Poly(ADP-Ribose) in Regulating WRN and RECQL5 Activities.	RECQL5 WRN	9.42e-07	3	20	2	26391948
Pubmed	RecQ helicase expression in patients with telomeropathies.	RECQL5 WRN	3.14e-06	5	20	2	38874681
Pubmed	RecQ helicases: suppressors of tumorigenesis and premature aging.	RECQL5 WRN	3.14e-06	5	20	2	12803543
Pubmed	Expression of Cornified Envelope Proteins in Skin and Its Relationship with Atopic Dermatitis Phenotype.	FLG FLG2	4.71e-06	6	20	2	27304082
Pubmed	Divergent Roles for Macrophage C-type Lectin Receptors, Dectin-1 and Mannose Receptors, in the Intestinal Inflammatory Response.	MRC1 IGF2R	4.71e-06	6	20	2	32234475
Pubmed	Genetic variants associated with disordered eating.	FLG MGAM FLG2	1.45e-05	83	20	3	23568457
Pubmed	Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study.	RYR2 WRN	1.72e-05	11	20	2	17903301
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	RYR2 AMER1 IGF2R WRN FLG2	6.45e-05	777	20	5	35844135
Pubmed	Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients.	FLG FLG2	6.55e-05	21	20	2	19601998
Pubmed	Characterization of placental endocrine function and fetal brain development in a mouse model of small for gestational age.	MRC1 IGF2R	2.42e-04	40	20	2	36843585
Pubmed	A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.	AMER1 USP54 FBXW5	3.07e-04	232	20	3	25515538
Pubmed	Specific pupylation as IDEntity reporter (SPIDER) for the identification of protein-biomolecule interactions.	FLG IGF2R	4.75e-04	56	20	2	37059927
Cytoband	1q21.3	FLG FLG2	1.19e-03	117	20	2	1q21.3
Cytoband	Ensembl 112 genes in cytogenetic band chr7q22	SRRT PLOD3	4.07e-03	219	20	2	chr7q22
Cytoband	Ensembl 112 genes in cytogenetic band chr1q21	FLG FLG2	1.32e-02	404	20	2	chr1q21
GeneFamily	RecQ like helicases	RECQL5 WRN	4.03e-06	5	12	2	1049
GeneFamily	EF-hand domain containing\|S100 fused type protein family	FLG FLG2	8.46e-06	7	12	2	1350
GeneFamily	EF-hand domain containing	FLG RYR2 FLG2	3.56e-04	219	12	3	863
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	MRC1 IGF2R	2.71e-02	394	12	2	471
Drug	europium	MGAM RYR2 PLOD3 WRN	9.19e-07	87	20	4	CID000023981
Drug	Cyclic ADP-Ribose	RYR2 PARG	4.39e-06	4	20	2	ctd:D036563
Drug	AC1NERK2	MGAM OVGP1	4.01e-05	11	20	2	CID004622009
Drug	picolinamide	MGAM WRN	6.63e-05	14	20	2	CID000015070
Drug	MS-8	RECQL5 WRN	9.89e-05	17	20	2	CID002398714
Drug	AC1L380G	MGAM RYR2	1.24e-04	19	20	2	CID000084698
Drug	pyroantimonate	SRRT MGAM	2.73e-04	28	20	2	CID006327644
Drug	benzo(c)phenanthrene	RECQL5 WRN	3.81e-04	33	20	2	CID000009136
Drug	mag-fura-2	MGAM RYR2	4.79e-04	37	20	2	CID000123839
Drug	AC1L9K36	MGAM RECQL5	5.89e-04	41	20	2	CID000446779
Drug	trichloramine	RECQL5 WRN	5.89e-04	41	20	2	CID000061437
Drug	Prilocaine hydrochloride [1786-81-8]; Down 200; 15.6uM; MCF7; HT_HG-U133A	SRRT RYR2 RECQL5	6.15e-04	193	20	3	3624_DN
Drug	Ketotifen fumarate [34580-14-8]; Down 200; 9.4uM; MCF7; HT_HG-U133A	SRRT RECQL5 OVGP1	6.15e-04	193	20	3	3200_DN
Drug	Mexiletine hydrochloride [5370-01-4]; Down 200; 18.6uM; PC3; HT_HG-U133A	SRRT NID2 RECQL5	6.15e-04	193	20	3	4338_DN
Drug	km h	MGAM PLOD3	6.18e-04	42	20	2	CID000021954
Drug	Hydroxytacrine maleate (R,S) [118909-22-1]; Down 200; 12.2uM; PC3; HT_HG-U133A	SRRT RYR2 OVGP1	6.24e-04	194	20	3	6651_DN
Drug	Bendroflumethiazide [73-48-3]; Down 200; 9.4uM; MCF7; HT_HG-U133A	SRRT RECQL5 OVGP1	6.24e-04	194	20	3	3840_DN
Drug	Hydroxytacrine maleate (R,S) [118909-22-1]; Down 200; 12.2uM; HL60; HT_HG-U133A	SRRT RECQL5 OVGP1	6.24e-04	194	20	3	2430_DN
Drug	Iproniazide phosphate [305-33-9]; Down 200; 14.4uM; PC3; HT_HG-U133A	RYR2 RECQL5 OVGP1	6.33e-04	195	20	3	2125_DN
Drug	Guanethidine sulfate [60-02-6]; Up 200; 13.4uM; MCF7; HT_HG-U133A	MGAM RYR2 RECQL5	6.43e-04	196	20	3	3171_UP
Drug	(1)-Nipecotic acid [498-95-3]; Up 200; 31uM; MCF7; HT_HG-U133A	NID2 RECQL5 OVGP1	6.43e-04	196	20	3	5999_UP
Drug	Amidopyrine [58-15-1]; Down 200; 17.2uM; MCF7; HT_HG-U133A	SRRT RYR2 RECQL5	6.52e-04	197	20	3	2222_DN
Drug	Ipratropium bromide [22254-24-6]; Up 200; 9.8uM; PC3; HT_HG-U133A	SRRT RYR2 RECQL5	6.52e-04	197	20	3	5823_UP
Drug	Acetohexamide [968-81-0]; Up 200; 12.4uM; MCF7; HT_HG-U133A	MGAM RYR2 OVGP1	6.52e-04	197	20	3	7482_UP
Drug	genistein; Down 200; 10uM; HL60; HT_HG-U133A	SRRT RECQL5 OVGP1	6.52e-04	197	20	3	2695_DN
Drug	LY 294002; Down 200; 0.1uM; PC3; HT_HG-U133A	NID2 RECQL5 OVGP1	6.52e-04	197	20	3	4440_DN
Drug	Antipyrine, 4-hydroxy [1672-63-5]; Up 200; 19.6uM; HL60; HG-U133A	SRRT MGAM OVGP1	6.52e-04	197	20	3	1997_UP
Drug	AH23848 hemicalcium salt hydrate; Down 200; 1uM; PC3; HT_HG-U133A	NID2 RECQL5 OVGP1	6.62e-04	198	20	3	6885_DN
Drug	Proparacaine hydrochloride [5875-06-9]; Down 200; 12uM; MCF7; HT_HG-U133A	RYR2 RECQL5 OVGP1	6.62e-04	198	20	3	5433_DN
Drug	Astemizole [68844-77-9]; Down 200; 8.8uM; MCF7; HT_HG-U133A	SRRT RYR2 RECQL5	6.62e-04	198	20	3	2211_DN
Drug	Metolazone [17560-51-9]; Up 200; 11uM; PC3; HT_HG-U133A	SRRT RECQL5 OVGP1	6.62e-04	198	20	3	6292_UP
Drug	Oxamniquine [21738-42-1]; Down 200; 14.4uM; PC3; HT_HG-U133A	NID2 RYR2 RECQL5	6.62e-04	198	20	3	4006_DN
Drug	Isocarboxazid [59-63-2]; Up 200; 17.2uM; MCF7; HT_HG-U133A	RYR2 RECQL5 OVGP1	6.62e-04	198	20	3	3424_UP
Drug	Citalopram hydrobromide [59729-32-7]; Down 200; 1uM; PC3; HT_HG-U133A	NID2 RYR2 OVGP1	6.72e-04	199	20	3	4555_DN
Drug	Bemegride [64-65-3]; Down 200; 25.8uM; MCF7; HT_HG-U133A	SRRT RECQL5 OVGP1	6.72e-04	199	20	3	5014_DN
Drug	Lobeline alpha (-) hydrochoride [134-63-4]; Down 200; 10.6uM; PC3; HT_HG-U133A	NID2 RYR2 OVGP1	6.72e-04	199	20	3	5784_DN
Drug	N-acetylhexosamine	MRC1 MGAM OVGP1 IGF2R	6.79e-04	472	20	4	CID000000899
Drug	CP-320650-01 [172079-28-6]; Down 200; 10uM; MCF7; HT_HG-U133A	SRRT RYR2 RECQL5	6.82e-04	200	20	3	4379_DN
Drug	Fenbendazole [43210-67-9]; Down 200; 13.4uM; PC3; HT_HG-U133A	SRRT RECQL5 OVGP1	6.82e-04	200	20	3	4542_DN
Drug	Loperamide hydrochloride [34552-83-5]; Down 200; 7.8uM; MCF7; HT_HG-U133A	SRRT RYR2 RECQL5	6.82e-04	200	20	3	5632_DN
Drug	Dimaprit dihydrochloride [23256-33-9]; Up 200; 17uM; MCF7; HT_HG-U133A	SRRT RECQL5 OVGP1	6.82e-04	200	20	3	7480_UP
Drug	5-bromouracil	RECQL5 WRN	7.09e-04	45	20	2	CID000005802
Disease	exercise test	RYR2 WRN	8.23e-05	20	20	2	EFO_0004328

Protein segments in the cluster

Peptide	Gene	Start	Entry
SWVTRGATEADYHLH	APCDD1L	116	Q8NCL9
REAYAREAHTWEAHG	AMER1	606	Q5JTC6
RHSGSRHHEAASWAD	FLG	1231	P20930
HYGQWSGGRHEDSRL	PLOD3	586	O60568
KSGYRHSSWSEGEEH	FLG2	126	Q5D862
GETEHTSYRRDLEWH	MGAM	2031	O43451
SGAEDRHGYIWDRHY	FBXW5	486	Q969U6
AETYRWSRSHEDGSE	PARG	796	Q86W56
DHFYHTDWRRDGVVS	NID2	1326	Q14112
HGDCEAYDTRTDRWH	KLHL17	356	Q6TDP4
HYEGGAVSVHARSLW	RYR2	261	Q92736
LSYDLHGSWERFTGH	OVGP1	211	Q12889
SEHTFLWTDGRGVHY	MRC1	1016	P22897
ADYDRDHEWGFCRHS	IGF2R	1931	P11717
HFRGDYQTHDIGWSE	PTCH2	331	Q9Y6C5
HCISEWGHDFRDSFR	WRN	671	Q14191
SHVHYSRWEDGSRDG	SMIM1	6	B2RUZ4
RRDWDEHSSDPYHSG	SRRT	81	Q9BXP5
FHGRARCESEADWHG	RECQL5	971	O94762
DWRQSSYASHSGHRR	USP54	1641	Q70EL1