Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiondiacylglycerol binding

UNC13B CHPT1

1.25e-0416212GO:0019992
GeneOntologyMolecularFunctionGTPase activator activity

ARHGAP1 TAGAP ARHGAP35

2.98e-03279213GO:0005096
DomainRhoGAP

ARHGAP1 TAGAP ARHGAP35

4.44e-0562213SM00324
DomainRhoGAP

ARHGAP1 TAGAP ARHGAP35

4.66e-0563213PF00620
DomainRhoGAP_dom

ARHGAP1 TAGAP ARHGAP35

4.88e-0564213IPR000198
Domain-

ARHGAP1 TAGAP ARHGAP35

4.88e-05642131.10.555.10
DomainRHOGAP

ARHGAP1 TAGAP ARHGAP35

4.88e-0564213PS50238
DomainRho_GTPase_activation_prot

ARHGAP1 TAGAP ARHGAP35

1.26e-0488213IPR008936
DomainRRM_1

NONO NOL8 RALYL

1.56e-03208213PF00076
DomainRRM

NONO NOL8 RALYL

1.76e-03217213SM00360
DomainRRM_dom

NONO NOL8 RALYL

2.00e-03227213IPR000504
DomainRRM

NONO NOL8 RALYL

2.08e-03230213PS50102
Domain-

NONO NOL8 RALYL

2.46e-032442133.30.70.330
DomainNucleotide-bd_a/b_plait

NONO NOL8 RALYL

2.88e-03258213IPR012677
DomainKinase-like_dom

CSNK1G3 ARHGAP35 PDCD6IP

2.19e-02542213IPR011009
PathwayREACTOME_RHOJ_GTPASE_CYCLE

ARHGAP1 ARHGAP35

1.83e-0416182MM15605
PathwayREACTOME_CDC42_GTPASE_CYCLE

ARHGAP1 TAGAP ARHGAP35

2.18e-0494183MM15598
PathwayREACTOME_RHOA_GTPASE_CYCLE

ARHGAP1 TAGAP ARHGAP35

7.31e-04142183MM15576
PathwayREACTOME_RHOA_GTPASE_CYCLE

ARHGAP1 TAGAP ARHGAP35

8.40e-04149183M41805
PathwayREACTOME_CDC42_GTPASE_CYCLE

ARHGAP1 TAGAP ARHGAP35

9.42e-04155183M41808
PathwayREACTOME_RAC1_GTPASE_CYCLE

ARHGAP1 TAGAP ARHGAP35

1.34e-03175183MM15599
PathwayREACTOME_RND2_GTPASE_CYCLE

ARHGAP1 ARHGAP35

1.35e-0343182M41827
PathwayREACTOME_RND2_GTPASE_CYCLE

ARHGAP1 ARHGAP35

1.41e-0344182MM15678
PathwayREACTOME_RAC1_GTPASE_CYCLE

ARHGAP1 TAGAP ARHGAP35

1.55e-03184183M41809
PathwayREACTOME_RHO_GTPASE_CYCLE

ARHGAP1 TAGAP ARHGAP35 SH3RF1

2.01e-03439184MM15595
PathwayREACTOME_RHOD_GTPASE_CYCLE

ARHGAP1 ARHGAP35

2.04e-0353182M41811
PathwayREACTOME_RHO_GTPASE_CYCLE

ARHGAP1 TAGAP ARHGAP35 SH3RF1

2.20e-03450184M27078
PathwayREACTOME_RHOJ_GTPASE_CYCLE

ARHGAP1 ARHGAP35

2.20e-0355182M41815
PathwayREACTOME_RHOQ_GTPASE_CYCLE

ARHGAP1 ARHGAP35

2.44e-0358182MM15602
PathwayREACTOME_RHOQ_GTPASE_CYCLE

ARHGAP1 ARHGAP35

2.52e-0359182M41812
PathwayREACTOME_RHOD_GTPASE_CYCLE

ARHGAP1 ARHGAP35

2.96e-0364182MM15601
PathwayREACTOME_RHOB_GTPASE_CYCLE

ARHGAP1 ARHGAP35

3.43e-0369182MM15596
PathwayREACTOME_RHOB_GTPASE_CYCLE

ARHGAP1 ARHGAP35

3.53e-0370182M41806
PathwayREACTOME_RHOC_GTPASE_CYCLE

ARHGAP1 ARHGAP35

3.53e-0370182MM15597
PathwayREACTOME_RHOG_GTPASE_CYCLE

ARHGAP1 ARHGAP35

3.63e-0371182MM15604
PathwayREACTOME_RHOC_GTPASE_CYCLE

ARHGAP1 ARHGAP35

3.94e-0374182M41807
PathwayREACTOME_RHOG_GTPASE_CYCLE

ARHGAP1 ARHGAP35

3.94e-0374182M41814
Pubmed

Regulation of RhoA GTP hydrolysis by the GTPase-activating proteins p190, p50RhoGAP, Bcr, and 3BP-1.

ARHGAP1 ARHGAP35

2.08e-0642129548756
Pubmed

Exploring the functional interaction between POSH and ALIX and the relevance to HIV-1 release.

SH3RF1 PDCD6IP

2.08e-06421219393081
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

FGA NONO ESCO1 MYBBP1A CFAP97 BORA PDCD6IP

3.38e-06115521720360068
Pubmed

Interaction of Rac1 with GTPase-activating proteins and putative effectors. A comparison with Cdc42 and RhoA.

ARHGAP1 ARHGAP35

1.25e-0592129535855
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

ARHGAP1 NONO MYBBP1A KIAA1217 NOL8 PDCD6IP

7.49e-05125721636526897
Pubmed

HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137.

NONO MYBBP1A NOL8

9.49e-0514821332538781
Pubmed

Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif.

NONO KIAA1217

1.03e-042521212522145
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

ARHGAP1 IFT46 KIAA1217 CFAP97 BORA

1.29e-0485321528718761
Pubmed

Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition.

NONO MYBBP1A

1.30e-042821219596686
Pubmed

An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency.

NONO MYBBP1A

1.40e-042921219279220
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

FGA MYBBP1A KIAA1217 PDE4DIP ARHGAP35 PDCD6IP

1.53e-04143121637142655
Pubmed

A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein.

NONO MYBBP1A

1.60e-043121212171929
Pubmed

Proline-rich sequence recognition: II. Proteomics analysis of Tsg101 ubiquitin-E2-like variant (UEV) interactions.

NONO PDCD6IP

1.70e-043221219542561
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

NONO MYBBP1A KIAA1217 NOL8 ARHGAP35

1.97e-0493421533916271
Pubmed

Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.

ARHGAP1 NONO MYBBP1A ARHGAP35

2.05e-0449821436634849
Pubmed

New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.

NONO MYBBP1A KIAA1217 ARHGAP35

2.29e-0451321425798074
Pubmed

Systematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis.

UNC13B CSNK1G3 IFT46

2.63e-0420921326389662
Pubmed

The SMN interactome includes Myb-binding protein 1a.

NONO MYBBP1A

3.54e-044621219928837
Pubmed

Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset.

FGA PDCD6IP

4.18e-045021224769233
Pubmed

Discovery of a Human Testis-specific Protein Complex TEX101-DPEP3 and Selection of Its Disrupting Antibodies.

ARHGAP1 NONO PDCD6IP

4.38e-0424921330097533
Pubmed

The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation.

NONO MYBBP1A KIAA1217

4.59e-0425321329911972
Pubmed

Molecular Characterization of the Oncogene BTF3 and Its Targets in Colorectal Cancer.

NONO MYBBP1A KIAA1217 PDCD6IP

4.88e-0462621433644029
Pubmed

CHK2 kinase promotes pre-mRNA splicing via phosphorylating CDK11(p110).

NONO MYBBP1A

5.06e-045521223178491
Pubmed

Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.

NONO MYBBP1A NOL8

5.61e-0427121332433965
GeneFamilyRho GTPase activating proteins|BCH domain containing

ARHGAP1 TAGAP ARHGAP35

4.30e-0650123721
GeneFamilyRNA binding motif containing

NONO NOL8 RALYL

3.28e-04213123725
CoexpressionAtlasDevelopingGonad_e12.5_epididymis_emap-29139_top-relative-expression-ranked_500

NONO ESCO1 KIAA1217 CFAP97 SH3RF1

3.80e-05403215gudmap_developingGonad_e12.5_epididymis_500
CoexpressionAtlasDevelopingGonad_e12.5_ovary_emap-28876_top-relative-expression-ranked_1000

CHPT1 NONO ESCO1 KIAA1217 CFAP97 SH3RF1

9.63e-05804216gudmap_developingGonad_e12.5_ovary_1000
CoexpressionAtlasDevelopingGonad_e12.5_epididymis_emap-29139_top-relative-expression-ranked_1000

NONO ESCO1 KIAA1217 CFAP97 NOL8 SH3RF1

9.76e-05806216gudmap_developingGonad_e12.5_epididymis_1000
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

UNC13B CHPT1 KIAA1217 SH3RF1

1.12e-06170214a2c738e441ced90eeeb1fcc6ca3269b918aaa298
ToppCellControl-Epithelial_cells-Airway_club|Control / group, cell type (main and fine annotations)

UNC13B KIAA1217 RALYL SH3RF1

1.44e-06181214c755d23dd9aabc717dc73e2b3fa99a1f751e6507
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

ARHGAP1 PDE4DIP ARHGAP35

7.06e-051732137e2149205e119cec4f5099c83c85d1e13470137a
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

CHPT1 KIAA1217 SH3RF1

7.68e-05178213f5ed4a6e3eb8056b1be1fb311021710c95bdf888
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|Children_(3_yrs) / Lineage, Cell type, age group and donor

UNC13B KIAA1217 SH3RF1

7.81e-05179213cb38b54261a7af5ee3347e64c8aa880a77ed0763
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CHPT1 RALYL SH3RF1

7.94e-05180213788d5fbf688365b5d92d3aa19b9f8e9448f8be5a
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Adult / Lineage, Cell type, age group and donor

UNC13B CHPT1 KIAA1217

8.61e-05185213673f0c688ae6984bc8027df2da335787924f4137
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Children_(3_yrs) / Lineage, Cell type, age group and donor

UNC13B KIAA1217 SH3RF1

8.61e-0518521398b8ee42b89d97e4c9db01740e0c193503c68f2c
ToppCellCOPD-Epithelial-Club|World / Disease state, Lineage and Cell class

UNC13B KIAA1217 SH3RF1

8.75e-051862133006f4ab1eaf1eb34c10ca9f7c869603d2d25744
ToppCellEpithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|World / Lineage, Cell type, age group and donor

UNC13B KIAA1217 SH3RF1

8.89e-0518721381cc8435b2704a9a8287b3f54acaae0f11dd4ac7
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

CHPT1 TAGAP CSNK1G3

9.32e-051902130724665ac8238f2383c3a929d89abf4a48ec2420
ToppCellEpithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|World / Lineage, Cell type, age group and donor

UNC13B KIAA1217 SH3RF1

9.47e-05191213d3733c8c4bda70c4390e5601fdda6188a64be944
ToppCellChildren_(3_yrs)-Epithelial|Children_(3_yrs) / Lineage, Cell type, age group and donor

UNC13B KIAA1217 SH3RF1

9.47e-05191213e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCellrenal_papilla_nuclei-Adult_normal_reference|renal_papilla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

CHPT1 KIAA1217 PDE4DIP

9.62e-051922136c106b91e46eabbe686a52a65a9c94ad9cbe9390
ToppCellLV-04._Ventricular_Cardiomyocyte_I|LV / Chamber and Cluster_Paper

CHPT1 PDE4DIP RALYL

9.62e-05192213ad19e2c1d36a0566c9b12ced10db78f4781c8ea6
ToppCellAdult-Epithelial|Adult / Lineage, Cell type, age group and donor

UNC13B KIAA1217 SH3RF1

9.62e-05192213efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCellEpithelial|World / Lineage, Cell type, age group and donor

UNC13B KIAA1217 SH3RF1

9.62e-05192213499e8893afea5e6d3371e0bd018f7e86a524d669
ToppCellFetal_29-31_weeks-Epithelial|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

UNC13B KIAA1217 SH3RF1

9.76e-05193213a0ca3231992f14abcf1a6129573bace320e89d2a
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_B|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

CHPT1 TAGAP CSNK1G3

9.76e-05193213ac227ddabfb3f021b1b39dba73f898517cd5a58e
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_B-B_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

CHPT1 TAGAP CSNK1G3

9.76e-05193213f4135615ee0118eec9e221becdd67888e0c2a112
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

CHPT1 TAGAP CSNK1G3

9.91e-051942135cd72330c9d9bb21b6c9d5d35085eade101486d1
ToppCell10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig-C|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ESCO1 ZNF786 CFAP97

9.91e-051942136be74e4ba631b0c46cef2c580553f4c1ed29579e
ToppCellPBMC-Severe-Lymphocyte-B-B_cell-B_naive-B_naive-4|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CHPT1 TAGAP CSNK1G3

9.91e-0519421324f9de4781666c96c4a2d04f8a444543dbd99cbe
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Epithelial-Epithelial,_Airway-ciliated_cell-Epi-Ciliated|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

UNC13B KIAA1217 SH3RF1

1.02e-04196213808c0a7d1889a8f3508ed9790c6dc7ec16bbc840
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Epithelial-Epithelial,_Airway-ciliated_cell|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

UNC13B KIAA1217 SH3RF1

1.02e-04196213b246e482f012dd9782b49c2a953acedfa3c1139d
ToppCellCOPD-Endothelial-VE_Capillary_B|Endothelial / Disease state, Lineage and Cell class

UNC13B KIAA1217 SH3RF1

1.04e-0419721330dbc05ea66892d2e18ff375ffa86d1db7bc4083
ToppCellBronchial-NucSeq-Epithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

UNC13B KIAA1217 SH3RF1

1.07e-041992135f7da3eab58ace6cddb3179a415cd839d5767958
ToppCellParenchymal-NucSeq-Epithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

UNC13B KIAA1217 SH3RF1

1.07e-041992135cea0d9e261903e0eaad60c28a07dff72ce65027
ToppCellSevere-B_naive-4|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)

CHPT1 TAGAP CSNK1G3

1.07e-04199213e02e482cca6a00d2980e750bca6de598819aa1b2
ToppCellsevere-B_naive|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

CHPT1 TAGAP CSNK1G3

1.08e-042002130e86f52b6e146d9bbc728d8fb176fc2b53696558
ToppCellTracheal-NucSeq-Epithelial-Epi_submucosal-gland|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

KIAA1217 RALYL SH3RF1

1.08e-042002130eb9ad8c0373bcc62029ec21c590ed03aaacd039
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW13-Neuronal-Cortical_neuron|GW13 / Sample Type, Dataset, Time_group, and Cell type.

MYBBP1A RALYL

1.15e-04342126c9c477b43009cded5a2e1a1792c32c40d9309a8
Diseasebody weight

UNC13B KIAA1217 RALYL SH3RF1

9.29e-031261204EFO_0004338
Diseasefat body mass

RALYL SH3RF1

9.37e-03217202EFO_0005409

Protein segments in the cluster

PeptideGeneStartEntry
SVKAKHNLMTVEQNN

PRPF4B

606

Q13523
HNLMTVEQNNGSSQK

PRPF4B

611

Q13523
KDTKNVNSNTGMQTT

CFAP97

46

Q9P2B7
MTGKTQTSNVTNKND

RALYL

1

Q86SE5
MQSNKTFNLEKQNHT

NONO

1

Q15233
VSHQEFSKMKQSNNE

PDCD6IP

631

Q8WUM4
DSVASNNKDQNSMKH

NOL8

591

Q76FK4
QHRDKMQQSKNQSAD

CSNK1G3

351

Q9Y6M4
STNNQKKAQDSSLHM

MYBBP1A

426

Q9BQG0
LTENSKQHNITQHMK

IFT46

151

Q9NQC8
KSQAFNMKQDHTTQR

BORA

531

Q6PGQ7
QKNNKDSHSLTTNIM

FGA

96

P02671
EMKKSVHTQVNTNTT

ESCO1

261

Q5FWF5
SHNASKTLNANNMET

TAGAP

6

Q8N103
QQEHKRKASSSGNMN

SLC26A8

36

Q96RN1
VQISAHSDQNKMTNT

ARHGAP1

376

Q07960
SVVQNNNTSQMSHKK

KIAA1217

1491

Q5T5P2
KVSHNNKVNLMTSEN

ARHGAP35

1381

Q9NRY4
ANKSSQASQNRHSME

SH3RF1

311

Q7Z6J0
EQVQVLSSKSHQNNM

CHPT1

391

Q8WUD6
NKAAHVQQMKTVKQS

UNC13B

576

O14795
SQQAMNSGKTKSHFQ

ZNF786

101

Q8N393
TTEHLKNANQQKESM

PDE4DIP

2296

Q5VU43