Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	opsonin binding	CLEC7A CFHR1 CFHR2 CFHR5 CFHR4 CFHR3	1.59e-11	25	45	6	GO:0001846
GeneOntologyMolecularFunction	complement component C3b binding	CFHR1 CFHR2 CFHR5 CFHR4 CFHR3	3.62e-11	12	45	5	GO:0001851
GeneOntologyMolecularFunction	complement binding	CFHR1 CFHR2 CFHR5 CR2 CFHR4 CFHR3	8.03e-11	32	45	6	GO:0001848
GeneOntologyMolecularFunction	immunoglobulin receptor binding	CR2 IGHE	1.01e-03	21	45	2	GO:0034987
GeneOntologyMolecularFunction	peroxisome proliferator activated receptor binding	NCOR1 ASXL1	1.01e-03	21	45	2	GO:0042975
GeneOntologyBiologicalProcess	complement activation	CFHR1 CFHR2 CFHR5 CR2 IGHE CFHR4 CFHR3	1.32e-10	70	44	7	GO:0006956
GeneOntologyBiologicalProcess	humoral immune response	CFHR1 AIRE CFHR2 CFHR5 CR2 IGHE CFHR4 CFHR3	3.43e-07	321	44	8	GO:0006959
GeneOntologyBiologicalProcess	cytolysis by host of symbiont cells	CFHR1 CFHR2 CFHR5	1.08e-06	10	44	3	GO:0051838
GeneOntologyBiologicalProcess	immune effector process	CLEC7A CFHR1 AIRE CFHR2 CFHR5 CR2 IGHE IL6R INPP5D CFHR4 CFHR3	1.33e-06	859	44	11	GO:0002252
GeneOntologyBiologicalProcess	activation of immune response	CLEC7A CFHR1 CFHR2 CFHR5 CR2 IGHE INPP5D CFHR4 CFHR3	5.44e-06	623	44	9	GO:0002253
GeneOntologyBiologicalProcess	complement activation, alternative pathway	CFHR5 CR2 CFHR4	8.57e-06	19	44	3	GO:0006957
GeneOntologyBiologicalProcess	glomerulus development	WT1 ASXL1 IL6R CFHR4	2.18e-05	77	44	4	GO:0032835
GeneOntologyBiologicalProcess	nephron development	WT1 LAMA5 ASXL1 IL6R CFHR4	3.36e-05	174	44	5	GO:0072006
GeneOntologyBiologicalProcess	positive regulation of immune system process	SELP CLEC7A CFHR1 CFHR2 CFHR5 CR2 IGHE IL6R INPP5D CFHR4 CFHR3	4.38e-05	1242	44	11	GO:0002684
GeneOntologyBiologicalProcess	cell killing	CLEC7A CFHR1 CFHR2 CFHR5 IGHE CFHR4	4.54e-05	307	44	6	GO:0001906
GeneOntologyBiologicalProcess	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	CLEC7A AIRE CR2 IGHE IL6R INPP5D CFHR4	5.06e-05	462	44	7	GO:0002460
GeneOntologyBiologicalProcess	positive regulation of immune response	CLEC7A CFHR1 CFHR2 CFHR5 CR2 IGHE INPP5D CFHR4 CFHR3	6.07e-05	845	44	9	GO:0050778
GeneOntologyBiologicalProcess	killing by host of symbiont cells	CFHR1 CFHR2 CFHR5	7.25e-05	38	44	3	GO:0051873
GeneOntologyBiologicalProcess	definitive erythrocyte differentiation	NCOR1 SENP1	1.24e-04	8	44	2	GO:0060318
GeneOntologyBiologicalProcess	kidney development	WT1 LAMA5 ASXL1 IL6R PCNT CFHR4	1.31e-04	372	44	6	GO:0001822
GeneOntologyBiologicalProcess	renal system development	WT1 LAMA5 ASXL1 IL6R PCNT CFHR4	1.60e-04	386	44	6	GO:0072001
GeneOntologyBiologicalProcess	disruption of cell in another organism	CLEC7A CFHR1 CFHR2 CFHR5	1.63e-04	129	44	4	GO:0141061
GeneOntologyBiologicalProcess	killing of cells of another organism	CLEC7A CFHR1 CFHR2 CFHR5	1.63e-04	129	44	4	GO:0031640
GeneOntologyBiologicalProcess	disruption of anatomical structure in another organism	CLEC7A CFHR1 CFHR2 CFHR5	1.78e-04	132	44	4	GO:0141060
GeneOntologyBiologicalProcess	regulation of glomerular mesangial cell proliferation	WT1 IL6R	3.98e-04	14	44	2	GO:0072124
GeneOntologyBiologicalProcess	regulation of immune response	CLEC7A CFHR1 CFHR2 CFHR5 CR2 IGHE INPP5D CFHR4 CFHR3	3.99e-04	1085	44	9	GO:0050776
GeneOntologyBiologicalProcess	glomerular mesangial cell proliferation	WT1 IL6R	4.59e-04	15	44	2	GO:0072110
GeneOntologyBiologicalProcess	glomerular mesangium development	WT1 IL6R	6.66e-04	18	44	2	GO:0072109
GeneOntologyBiologicalProcess	regulation of cell proliferation involved in kidney development	WT1 IL6R	6.66e-04	18	44	2	GO:1901722
GeneOntologyBiologicalProcess	positive regulation of chemokine production	CLEC7A AIRE IL6R	7.65e-04	84	44	3	GO:0032722
GeneOntologyBiologicalProcess	connective tissue development	WT1 HSPG2 CR2 IL6R CFHR4	7.88e-04	343	44	5	GO:0061448
GeneOntologyBiologicalProcess	lymphocyte differentiation	AIRE NCOR1 CR2 IGHE IL6R INPP5D	9.23e-04	537	44	6	GO:0030098
GeneOntologyBiologicalProcess	podocyte differentiation	WT1 ASXL1	1.00e-03	22	44	2	GO:0072112
GeneOntologyBiologicalProcess	glomerular epithelial cell differentiation	WT1 ASXL1	1.00e-03	22	44	2	GO:0072311
GeneOntologyBiologicalProcess	renal filtration cell differentiation	WT1 ASXL1	1.00e-03	22	44	2	GO:0061318
HumanPheno	Abnormality of temperature regulation	WT1 CLEC7A CFHR1 HSPG2 ASXL1 CR2 IL6R CFHR3 TG	6.76e-06	568	15	9	HP:0004370
HumanPheno	Foveal hypopigmentation	CFHR1 CFHR3	4.84e-05	4	15	2	HP:0012643
HumanPheno	Decreased circulating complement factor H concentration	CFHR1 CFHR3	4.84e-05	4	15	2	HP:0005369
HumanPheno	Decreased circulating complement factor I concentration	CFHR1 CFHR3	8.05e-05	5	15	2	HP:0005356
HumanPheno	Decreased circulating complement factor B concentration	CFHR1 CFHR3	8.05e-05	5	15	2	HP:0005416
HumanPheno	Abnormal femoral epiphysis morphology	HSPG2 RAB3GAP2 PCNT TG	8.97e-05	86	15	4	HP:0006499
HumanPheno	Abnormal lower limb epiphysis morphology	HSPG2 RAB3GAP2 PCNT TG	1.27e-04	94	15	4	HP:0006500
HumanPheno	Macular hemorrhage	CFHR1 CFHR3	1.69e-04	7	15	2	HP:0025574
HumanPheno	Geographic atrophy	CFHR1 CFHR3	1.69e-04	7	15	2	HP:0031609
HumanPheno	Macular drusen	CFHR1 CFHR3	2.24e-04	8	15	2	HP:0030499
HumanPheno	Abnormality of foveal pigmentation	CFHR1 CFHR3	2.24e-04	8	15	2	HP:0030493
HumanPheno	Decreased circulating complement C3 concentration	CFHR1 CR2 CFHR3	2.38e-04	43	15	3	HP:0005421
Domain	Sushi	SELP CFHR1 CFHR2 CFHR5 CR2 CFHR4 CFHR3	3.02e-11	52	44	7	PF00084
Domain	CCP	SELP CFHR1 CFHR2 CFHR5 CR2 CFHR4 CFHR3	3.98e-11	54	44	7	SM00032
Domain	SUSHI	SELP CFHR1 CFHR2 CFHR5 CR2 CFHR4 CFHR3	5.19e-11	56	44	7	PS50923
Domain	Sushi_SCR_CCP_dom	SELP CFHR1 CFHR2 CFHR5 CR2 CFHR4 CFHR3	5.91e-11	57	44	7	IPR000436
Domain	EGF_1	SELP LAMA5 HSPG2 ITGBL1 LRP1B NTN3	2.79e-05	255	44	6	PS00022
Domain	EGF_2	SELP LAMA5 HSPG2 ITGBL1 LRP1B NTN3	3.46e-05	265	44	6	PS01186
Domain	EGF_LAM_2	LAMA5 HSPG2 NTN3	4.74e-05	30	44	3	PS50027
Domain	EGF_LAM_1	LAMA5 HSPG2 NTN3	4.74e-05	30	44	3	PS01248
Domain	Znf_PHD	AIRE ASXL1 JADE3 BAZ2A	6.17e-05	91	44	4	IPR001965
Domain	ZF_PHD_2	AIRE ASXL1 JADE3 BAZ2A	7.30e-05	95	44	4	PS50016
Domain	Laminin_EGF	LAMA5 HSPG2 NTN3	7.57e-05	35	44	3	PF00053
Domain	EGF_Lam	LAMA5 HSPG2 NTN3	7.57e-05	35	44	3	SM00180
Domain	ZF_PHD_1	AIRE ASXL1 JADE3 BAZ2A	7.60e-05	96	44	4	PS01359
Domain	Laminin_EGF	LAMA5 HSPG2 NTN3	9.71e-05	38	44	3	IPR002049
Domain	LAMININ_IVA	LAMA5 HSPG2	1.51e-04	8	44	2	PS51115
Domain	Laminin_B	LAMA5 HSPG2	1.51e-04	8	44	2	PF00052
Domain	LamB	LAMA5 HSPG2	1.51e-04	8	44	2	SM00281
Domain	Laminin_IV	LAMA5 HSPG2	1.51e-04	8	44	2	IPR000034
Domain	EGF	SELP LAMA5 HSPG2 ITGBL1 LRP1B	2.20e-04	235	44	5	SM00181
Domain	EGF-like_dom	SELP LAMA5 HSPG2 ITGBL1 LRP1B	2.87e-04	249	44	5	IPR000742
Domain	EGF-like_CS	SELP LAMA5 HSPG2 LRP1B NTN3	3.57e-04	261	44	5	IPR013032
Domain	Growth_fac_rcpt_	LAMA5 HSPG2 LRP1B NTN3	4.90e-04	156	44	4	IPR009030
Domain	LAMININ_NTER	LAMA5 NTN3	6.37e-04	16	44	2	PS51117
Domain	Laminin_N	LAMA5 NTN3	6.37e-04	16	44	2	PF00055
Domain	Laminin_N	LAMA5 NTN3	6.37e-04	16	44	2	IPR008211
Domain	LamNT	LAMA5 NTN3	6.37e-04	16	44	2	SM00136
Domain	PHD	AIRE JADE3 BAZ2A	7.32e-04	75	44	3	PF00628
Domain	Znf_PHD-finger	AIRE JADE3 BAZ2A	8.51e-04	79	44	3	IPR019787
Domain	PHD	AIRE JADE3 BAZ2A	1.20e-03	89	44	3	SM00249
Domain	SANT_dom	NCOR1 ZNF541	1.70e-03	26	44	2	IPR017884
Domain	SANT	NCOR1 ZNF541	1.97e-03	28	44	2	PS51293
Domain	Myb_DNA-binding	NCOR1 ZNF541	3.07e-03	35	44	2	PF00249
Domain	EGF	SELP HSPG2 LRP1B	3.24e-03	126	44	3	PF00008
Domain	LAM_G_DOMAIN	LAMA5 HSPG2	3.61e-03	38	44	2	PS50025
Domain	MYB_LIKE	NCOR1 ZNF541	3.61e-03	38	44	2	PS50090
Domain	Laminin_G_2	LAMA5 HSPG2	4.00e-03	40	44	2	PF02210
Domain	LDLR_class-A_CS	HSPG2 LRP1B	4.00e-03	40	44	2	IPR023415
Domain	LamG	LAMA5 HSPG2	4.82e-03	44	44	2	SM00282
Domain	Znf_FYVE_PHD	AIRE JADE3 BAZ2A	5.00e-03	147	44	3	IPR011011
Domain	Ldl_recept_a	HSPG2 LRP1B	5.04e-03	45	44	2	PF00057
Domain	-	HSPG2 LRP1B	5.26e-03	46	44	2	4.10.400.10
Domain	LDLRA_1	HSPG2 LRP1B	5.71e-03	48	44	2	PS01209
Domain	LDrepeatLR_classA_rpt	HSPG2 LRP1B	5.95e-03	49	44	2	IPR002172
Domain	LDLa	HSPG2 LRP1B	5.95e-03	49	44	2	SM00192
Domain	LDLRA_2	HSPG2 LRP1B	5.95e-03	49	44	2	PS50068
Domain	SANT	NCOR1 ZNF541	6.18e-03	50	44	2	SM00717
Domain	SANT/Myb	NCOR1 ZNF541	6.67e-03	52	44	2	IPR001005
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_COMPLEMENT_CASCADE_CFHR	CFHR1 CFHR2 CFHR5 CFHR4 CFHR3	2.60e-13	6	32	5	M47880
Pathway	REACTOME_COMPLEMENT_CASCADE	CFHR1 CFHR2 CFHR5 CR2 CFHR4 CFHR3	1.97e-07	115	32	6	M19752
Pathway	WP_COMPLEMENT_SYSTEM	SELP LAMA5 CFHR2 CR2 CFHR4	2.30e-06	96	32	5	M39581
Pathway	REACTOME_COMPLEMENT_CASCADE	CFHR1 CFHR2 CR2 CFHR4	3.71e-05	84	32	4	MM14653
Pubmed	Factor H-related proteins determine complement-activating surfaces.	CFHR1 CFHR2 CFHR5 CFHR4 CFHR3	3.62e-15	5	47	5	25979655
Pubmed	Sequence and Expression of Complement Factor H Gene Cluster Variants and Their Roles in Age-Related Macular Degeneration Risk.	CFHR1 CFHR2 CFHR5 CFHR4 CFHR3	2.17e-14	6	47	5	27196323
Pubmed	Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: characterization, ethnic distribution and evolutionary implications.	CFHR1 CFHR2 CFHR5 CFHR4 CFHR3	2.17e-14	6	47	5	17438673
Pubmed	Epidemiological approach to identifying genetic predispositions for atypical hemolytic uremic syndrome.	CFHR1 CFHR2 CFHR5 CFHR4 CFHR3	4.54e-13	9	47	5	20059470
Pubmed	Identification and sequence analysis of four complement factor H-related transcripts in mouse liver.	CFHR1 CFHR2 CFHR4 CFHR3	1.46e-11	5	47	4	1689298
Pubmed	A radiation hybrid map of complement factor H and factor H-related genes.	CFHR1 CFHR2 CFHR4 CFHR3	1.46e-11	5	47	4	10380701
Pubmed	Dimerization of complement factor H-related proteins modulates complement activation in vivo.	CFHR1 CFHR2 CFHR5 CFHR4	4.38e-11	6	47	4	23487775
Pubmed	FHR-1 Binds to C-Reactive Protein and Enhances Rather than Inhibits Complement Activation.	CFHR1 CFHR5 CFHR4 CFHR3	3.67e-10	9	47	4	28533443
Pubmed	Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility.	CFHR1 CFHR4 CFHR3	2.31e-09	3	47	3	21637784
Pubmed	C3 glomerulopathy-associated CFHR1 mutation alters FHR oligomerization and complement regulation.	CFHR1 CFHR2 CFHR5	2.31e-09	3	47	3	23728178
Pubmed	Atypical haemolytic-uraemic syndrome due to heterozygous mutations of CFH/CFHR1-3 and complement factor H 479.	CFHR1 CFHR2 CFHR3	9.24e-09	4	47	3	24333077
Pubmed	CFH and CFHR structural variants in atypical Hemolytic Uremic Syndrome: Prevalence, genomic characterization and impact on outcome.	CFHR1 CFHR4 CFHR3	9.24e-09	4	47	3	36793547
Pubmed	Genome-wide association study identifies susceptibility loci for IgA nephropathy.	CFHR1 CFHR5 CFHR4 CFHR3	1.12e-08	19	47	4	21399633
Pubmed	Complement factor H and related proteins: an expanding family of complement-regulatory proteins?	CFHR1 CFHR2 CFHR3	2.31e-08	5	47	3	8172644
Pubmed	The NEI/NCBI dbGAP database: genotypes and haplotypes that may specifically predispose to risk of neovascular age-related macular degeneration.	CFHR2 CFHR5 CFHR4	4.61e-08	6	47	3	18541031
Pubmed	Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome.	CFHR1 CFHR4 CFHR3	8.06e-08	7	47	3	19861685
Pubmed	Genetic Atypical Hemolytic-Uremic Syndrome	CFHR1 CFHR4 CFHR3	3.79e-07	11	47	3	20301541
Pubmed	Deletion Variants of CFHR1 and CFHR3 Associate with Mesangial Immune Deposits but Not with Progression of IgA Nephropathy.	CFHR1 CFHR3	1.79e-06	2	47	2	29114042
Pubmed	Deficiency of Mouse FHR-1 Homolog, FHR-E, Accelerates Sepsis, and Acute Kidney Injury Through Enhancing the LPS-Induced Alternative Complement Pathway.	CFHR1 CFHR2	1.79e-06	2	47	2	32636836
Pubmed	Anti-factor H antibody and its role in atypical hemolytic uremic syndrome.	CFHR1 CFHR3	1.79e-06	2	47	2	36091034
Pubmed	Deletion of CFHR3 and CFHR1 genes in age-related macular degeneration.	CFHR1 CFHR3	1.79e-06	2	47	2	18084039
Pubmed	Common haplotypes at the CFH locus and low-frequency variants in CFHR2 and CFHR5 associate with systemic FHR concentrations and age-related macular degeneration.	CFHR2 CFHR5	1.79e-06	2	47	2	34260947
Pubmed	Molecular cloning of a human serum protein structurally related to complement factor H.	CFHR1 CFHR2	1.79e-06	2	47	2	1711047
Pubmed	A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration.	CFHR1 CFHR3	1.79e-06	2	47	2	16998489
Pubmed	Copy number variation in the complement factor H-related genes and age-related macular degeneration.	CFHR1 CFHR3	1.79e-06	2	47	2	21850184
Pubmed	A hybrid CFHR3-1 gene causes familial C3 glomerulopathy.	CFHR1 CFHR3	1.79e-06	2	47	2	22626820
Pubmed	Prompt plasma exchanges and immunosuppressive treatment improves the outcomes of anti-factor H autoantibody-associated hemolytic uremic syndrome in children.	CFHR1 CFHR3	1.79e-06	2	47	2	24088957
Pubmed	Contribution of copy number variation in the regulation of complement activation locus to development of age-related macular degeneration.	CFHR1 CFHR3	1.79e-06	2	47	2	19553609
Pubmed	Molecular bases for the association of FHR-1 with atypical hemolytic uremic syndrome and other diseases.	CFHR1 CFHR2	1.79e-06	2	47	2	33651882
Pubmed	Complement factor H-related hybrid protein deregulates complement in dense deposit disease.	CFHR2 CFHR5	1.79e-06	2	47	2	24334459
Pubmed	Complement Factor H-Related Proteins FHR1 and FHR5 Interact With Extracellular Matrix Ligands, Reduce Factor H Regulatory Activity and Enhance Complement Activation.	CFHR1 CFHR5	1.79e-06	2	47	2	35392081
Pubmed	Circulating complement factor H-related proteins 1 and 5 correlate with disease activity in IgA nephropathy.	CFHR1 CFHR5	1.79e-06	2	47	2	28673452
Pubmed	High prevalence of CFHR deletions in Indian women with pregnancy-associated hemolytic uremic syndrome.	CFHR1 CFHR3	1.79e-06	2	47	2	34796567
Pubmed	Fine Mapping Implicates a Deletion of CFHR1 and CFHR3 in Protection from IgA Nephropathy in Han Chinese.	CFHR1 CFHR3	1.79e-06	2	47	2	26940089
Pubmed	A novel CFHR1-CFHR5 hybrid leads to a familial dominant C3 glomerulopathy.	CFHR1 CFHR5	1.79e-06	2	47	2	28729035
Pubmed	Comprehensive analysis of Copy Number Variation of genes at chromosome 1 and 10 loci associated with late age related macular degeneration.	CFHR1 CFHR3	1.79e-06	2	47	2	22558131
Pubmed	SHIP-1 Couples to the Dectin-1 hemITAM and Selectively Modulates Reactive Oxygen Species Production in Dendritic Cells in Response to Candida albicans.	CLEC7A INPP5D	1.79e-06	2	47	2	26416276
Pubmed	The absence of CFHR3 and CFHR1 genes from the T2T-CHM13 assembly can limit the molecular diagnosis of complement-related diseases.	CFHR1 CFHR3	1.79e-06	2	47	2	37032353
Pubmed	Associations of CFHR1-CFHR3 deletion and a CFH SNP to age-related macular degeneration are not independent.	CFHR1 CFHR3	5.36e-06	3	47	2	20581873
Pubmed	Complement factor H, FHR-3 and FHR-1 variants associate in an extended haplotype conferring increased risk of atypical hemolytic uremic syndrome.	CFHR1 CFHR3	5.36e-06	3	47	2	26163426
Pubmed	Complement factor H: sequence analysis of 221 kb of human genomic DNA containing the entire fH, fHR-1 and fHR-3 genes.	CFHR1 CFHR3	5.36e-06	3	47	2	10781834
Pubmed	Association assessment of copy number polymorphism and risk of age-related macular degeneration.	CFHR1 CFHR3	5.36e-06	3	47	2	21856016
Pubmed	Functional properties of complement factor H-related proteins FHR-3 and FHR-4: binding to the C3d region of C3b and differential regulation by heparin.	CFHR4 CFHR3	5.36e-06	3	47	2	10622723
Pubmed	Variants in Complement Factor H and Complement Factor H-Related Protein Genes, CFHR3 and CFHR1, Affect Complement Activation in IgA Nephropathy.	CFHR1 CFHR3	5.36e-06	3	47	2	25205734
Pubmed	Factor H autoantibodies in atypical hemolytic uremic syndrome correlate with CFHR1/CFHR3 deficiency.	CFHR1 CFHR3	5.36e-06	3	47	2	18006700
Pubmed	Serum FHR1 binding to necrotic-type cells activates monocytic inflammasome and marks necrotic sites in vasculopathies.	CFHR1 CFHR2	5.36e-06	3	47	2	31273197
Pubmed	The structure of human CD23 and its interactions with IgE and CD21.	CR2 IGHE	5.36e-06	3	47	2	16172256
Pubmed	Atypical hemolytic uremic syndrome associated with complement factor H autoantibodies and CFHR1/CFHR3 deficiency.	CFHR1 CFHR3	5.36e-06	3	47	2	19531976
Pubmed	Complement-Regulatory Proteins CFHR1 and CFHR3 and Patient Response to Anti-CD20 Monoclonal Antibody Therapy.	CFHR1 CFHR3	5.36e-06	3	47	2	27528699
Pubmed	Targeted inhibition of the complement alternative pathway with complement receptor 2 and factor H attenuates collagen antibody-induced arthritis in mice.	CR2 CFHR4	5.36e-06	3	47	2	19828624
Pubmed	Evaluation of CFH Y402H polymorphism and CFHR3/CFHR1 deletion in age-related macular degeneration patients from Brazil.	CFHR1 CFHR3	5.36e-06	3	47	2	26942649
Pubmed	Deletions in Genes Participating in Innate Immune Response Modify the Clinical Course of Andes Orthohantavirus Infection.	CFHR1 CFHR3	5.36e-06	3	47	2	31349540
Pubmed	An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD).	CFHR1 CFHR3	5.36e-06	3	47	2	20843825
Pubmed	Associations of CFH polymorphisms and CFHR1-CFHR3 deletion with blood pressure and hypertension in Chinese population.	CFHR1 CFHR3	5.36e-06	3	47	2	22848687
Pubmed	A genome-wide association study identifies key modulators of complement factor H binding to malondialdehyde-epitopes.	CFHR1 CFHR3	5.36e-06	3	47	2	32321835
Pubmed	Two factor H-related proteins from the mouse: expression analysis and functional characterization.	CFHR4 CFHR3	5.36e-06	3	47	2	17028856
Pubmed	Localization of complement factor H gene expression and protein distribution in the mouse outer retina.	CFHR4 CFHR3	5.36e-06	3	47	2	25684976
Pubmed	Risk of non-Hodgkin lymphoma in association with germline variation in complement genes.	CFHR1 CFHR5 CR2	1.01e-05	31	47	3	19344414
Pubmed	Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndrome.	CFHR1 CFHR3	1.07e-05	4	47	2	17367211
Pubmed	Copy number polymorphisms in new HapMap III and Singapore populations.	CFHR1 CFHR3	1.07e-05	4	47	2	21677662
Pubmed	New genetic associations detected in a host response study to hepatitis B vaccine.	CLEC7A CFHR1 CFHR2 CFHR5 CR2 IL6R CFHR4 CFHR3	1.33e-05	824	47	8	20237496
Pubmed	Large-scale identification of genes implicated in kidney glomerulus development and function.	WT1 LAMA5 HSPG2	1.34e-05	34	47	3	16498405
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ASXL1 R3HDM2 BAZ2A STXBP5 RAB3GAP2 PCNT	1.77e-05	407	47	6	12693553
Pubmed	Molecular cloning of rat and mouse membrane cofactor protein (MCP, CD46): preferential expression in testis and close linkage between the mouse Mcp and Cr2 genes on distal chromosome 1.	CR2 CFHR4	1.78e-05	5	47	2	9799332
Pubmed	Molecular basis of C-reactive protein binding and modulation of complement activation by factor H-related protein 4.	CFHR4 CFHR3	1.78e-05	5	47	2	20042240
Pubmed	Complement-dependent P-selectin expression and injury following ischemic stroke.	SELP CR2	1.78e-05	5	47	2	17082645
Pubmed	Targeted complement inhibitors protect against posttransplant cardiac ischemia and reperfusion injury and reveal an important role for the alternative pathway of complement activation.	CR2 CFHR4	1.78e-05	5	47	2	20962256
Pubmed	Asynchrony of Apical Polarization, Luminogenesis, and Functional Differentiation in the Developing Thyroid Gland.	PCNT TG	2.67e-05	6	47	2	34975747
Pubmed	Nephronectin is required to maintain right lung lobar separation during embryonic development.	WT1 LAMA5	2.67e-05	6	47	2	36719987
Pubmed	Laminin alpha1 globular domains 4-5 induce fetal development but are not vital for embryonic basement membrane assembly.	LAMA5 HSPG2	2.67e-05	6	47	2	15668394
Pubmed	Growth of geographic atrophy on fundus autofluorescence and polymorphisms of CFH, CFB, C3, FHR1-3, and ARMS2 in age-related macular degeneration.	CFHR1 CFHR3	2.67e-05	6	47	2	24557084
Pubmed	Role of Asxl1 in kidney podocyte development via its interaction with Wtip.	WT1 ASXL1	3.74e-05	7	47	2	26385183
Pubmed	Additional sex comb-like 1 (ASXL1), in cooperation with SRC-1, acts as a ligand-dependent coactivator for retinoic acid receptor.	NCOR1 ASXL1	3.74e-05	7	47	2	16606617
Pubmed	Genetic organization of complement receptor-related genes in the mouse.	CR2 CFHR4	4.98e-05	8	47	2	2564419
Pubmed	C3 Glomerulopathy	CFHR1 CFHR5	4.98e-05	8	47	2	20301598
Pubmed	Laminin γ1 C-terminal Glu to Gln mutation induces early postimplantation lethality.	LAMA5 HSPG2	6.40e-05	9	47	2	30456378
Pubmed	Functional consequences of cell type-restricted expression of laminin α5 in mouse placental labyrinth and kidney glomerular capillaries.	WT1 LAMA5	7.99e-05	10	47	2	22911783
Pubmed	Genetic control of susceptibility to infection with Mycobacterium tuberculosis in mice.	SELP IL6R	7.99e-05	10	47	2	11197687
Pubmed	Generation of a conditionally null allele of the laminin alpha1 gene.	LAMA5 HSPG2	7.99e-05	10	47	2	16100707
Pubmed	Integrin alpha6beta1-laminin interactions regulate early myotome formation in the mouse embryo.	LAMA5 HSPG2	7.99e-05	10	47	2	16554364
Pubmed	Anuria, omphalocele, and perinatal lethality in mice lacking the CD34-related protein podocalyxin.	WT1 LAMA5	9.75e-05	11	47	2	11435469
Pubmed	Novel role for Netrins in regulating epithelial behavior during lung branching morphogenesis.	HSPG2 NTN3	9.75e-05	11	47	2	15186747
Pubmed	Crim1KST264/KST264 mice implicate Crim1 in the regulation of vascular endothelial growth factor-A activity during glomerular vascular development.	WT1 LAMA5	1.17e-04	12	47	2	17460146
Pubmed	Synergistic activities of alpha3 and alpha6 integrins are required during apical ectodermal ridge formation and organogenesis in the mouse.	LAMA5 HSPG2	1.17e-04	12	47	2	10433923
Pubmed	Molecular dissection of laminin alpha 5 in vivo reveals separable domain-specific roles in embryonic development and kidney function.	LAMA5 HSPG2	1.17e-04	12	47	2	16750824
Pubmed	Combined mutations of ASXL1, CBL, FLT3, IDH1, IDH2, JAK2, KRAS, NPM1, NRAS, RUNX1, TET2 and WT1 genes in myelodysplastic syndromes and acute myeloid leukemias.	WT1 ASXL1	1.17e-04	12	47	2	20678218
Pubmed	Lessons from thymic epithelial heterogeneity: FoxN1 and tissue-restricted gene expression by extrathymic, endodermally derived epithelium.	AIRE TG	1.17e-04	12	47	2	19786540
Pubmed	Gene order and genetic distance of 13 loci spanning murine chromosome 15.	CR2 TG	1.17e-04	12	47	2	1358803
Pubmed	Mesangial cells organize the glomerular capillaries by adhering to the G domain of laminin alpha5 in the glomerular basement membrane.	LAMA5 HSPG2	1.38e-04	13	47	2	12682087
Pubmed	ASXL1 mutation is associated with poor prognosis and acute transformation in chronic myelomonocytic leukaemia.	WT1 ASXL1	1.38e-04	13	47	2	20880116
Pubmed	Ischemic stroke is associated with the ABO locus: the EuroCLOT study.	CFHR5 CFHR4	1.61e-04	14	47	2	23381943
Pubmed	Genetic factors in nonsmokers with age-related macular degeneration revealed through genome-wide gene-environment interaction analysis.	CFHR5 CFHR4	1.61e-04	14	47	2	23577725
Pubmed	Membrane-type MMPs are indispensable for placental labyrinth formation and development.	LAMA5 HSPG2	1.61e-04	14	47	2	20858856
Pubmed	Sonic hedgehog-dependent synthesis of laminin alpha1 controls basement membrane assembly in the myotome.	LAMA5 HSPG2	1.61e-04	14	47	2	19783738
Pubmed	Basement membrane composition in the early mouse embryo day 7.	LAMA5 HSPG2	1.86e-04	15	47	2	15895400
Pubmed	Defective glomerulogenesis in the absence of laminin alpha5 demonstrates a developmental role for the kidney glomerular basement membrane.	WT1 LAMA5	1.86e-04	15	47	2	10625553
Pubmed	Ontogeny of stromal organizer cells during lymph node development.	LAMA5 HSPG2	2.12e-04	16	47	2	20237296
Pubmed	The fibronectin leucine-rich repeat transmembrane protein Flrt2 is required in the epicardium to promote heart morphogenesis.	WT1 HSPG2	2.12e-04	16	47	2	21350012
Pubmed	Microarray analysis of somitogenesis reveals novel targets of different WNT signaling pathways in the somitic mesoderm.	SELP BAZ2A	2.12e-04	16	47	2	12781685
Pubmed	Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFbeta2.	LAMA5 HSPG2	2.12e-04	16	47	2	17767158
Interaction	CFHR2 interactions	CFHR1 CFHR2	1.53e-05	3	46	2	int:CFHR2
Interaction	C3 interactions	ASXL1 CFHR5 CR2 CFHR4 CFHR3	2.68e-05	155	46	5	int:C3
Cytoband	Ensembl 112 genes in cytogenetic band chr1q31	CFHR1 CFHR2 CFHR5 CFHR4 CFHR3	1.48e-08	75	47	5	chr1q31
Cytoband	1q32	CFHR1 CR2 CFHR4 CFHR3	1.97e-07	49	47	4	1q32
Cytoband	6q24.3	SASH1 STXBP5	5.61e-05	11	47	2	6q24.3
Cytoband	1q31.3	CFHR2 CFHR5	1.22e-04	16	47	2	1q31.3
Cytoband	12q13.3	R3HDM2 BAZ2A	1.27e-03	51	47	2	12q13.3
Cytoband	Ensembl 112 genes in cytogenetic band chr6q24	SASH1 STXBP5	2.93e-03	78	47	2	chr6q24
Cytoband	21q22.3	AIRE PCNT	7.68e-03	128	47	2	21q22.3
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	SELP CFHR1 CFHR2 CFHR5 CR2 CFHR4 CFHR3	6.69e-12	57	32	7	1179
GeneFamily	Complement system\|Sushi domain containing	CFHR1 CFHR2 CFHR5 CR2 CFHR4 CFHR3	3.51e-11	36	32	6	492
GeneFamily	PHD finger proteins	AIRE JADE3 BAZ2A	5.33e-04	90	32	3	88
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	NCOR1 ZNF541	3.95e-03	53	32	2	532
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	SELP CLEC7A CR2 IL6R	4.93e-03	394	32	4	471
ToppCell	TCGA-Liver\|World / Sample_Type by Project: Shred V9	CFHR1 CFHR2 CFHR5 CFHR4 CFHR3	1.10e-06	174	47	5	452932f08cf53e5949672a025d78cecb874aa4b0
ToppCell	TCGA-Colorectal-Recurrent_Tumor\|TCGA-Colorectal / Sample_Type by Project: Shred V9	CFHR1 CFHR2 CFHR5 CFHR4 CFHR3	1.13e-06	175	47	5	7f74961436f88c0e380819095e6104489914d765
ToppCell	TCGA-Colorectal-Recurrent_Tumor-Colorectal_Adenocarcinoma\|TCGA-Colorectal / Sample_Type by Project: Shred V9	CFHR1 CFHR2 CFHR5 CFHR4 CFHR3	1.13e-06	175	47	5	bee8f31f036dfcf9fc6ed29156554771a9ee3c60
ToppCell	10x5'-GI_small-bowel-Lymphocytic_Invariant-Inducer-like-MAIT\|GI_small-bowel / Manually curated celltypes from each tissue	CFHR1 CFHR2 CFHR4 CFHR3	1.70e-05	146	47	4	1cb2e157222631e8915d89b255a843d16d7d99cc
ToppCell	Transplant_Alveoli_and_parenchyma-Epithelial-Type_1_alveolar\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	LAMA5 HSPG2 ITGBL1 IGHE	2.44e-05	160	47	4	58ed3a074932ccc951e07868dfdc61b99ae1cc2b
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP-PMP_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLBP MRNIP TEPSIN PCNT	3.09e-05	170	47	4	b1a16600754e0c12f7d39c9221f1b03135833f16
ToppCell	3'-GW_trimst-1-SmallIntestine-Mesenchymal-mesothelial_cell-Mesothelium_(RGS5+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	WT1 LAMA5 SPATA31E1 IL6R	3.46e-05	175	47	4	f5451c29c487b998778e50349b3d774d5e20fd28
ToppCell	IPF-Lymphoid-B\|World / Disease state, Lineage and Cell class	CR2 JADE3 IGHE INPP5D	3.86e-05	180	47	4	30f9398c9b784f49470847a025bac90687e997a1
ToppCell	5'-Adult-LymphNode-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SELP LAMA5 HSPG2 SASH1	4.12e-05	183	47	4	a644258ba90acc62d571623e429d72ffc4b69203
ToppCell	IPF-Lymphoid-B\|IPF / Disease state, Lineage and Cell class	CR2 JADE3 IGHE INPP5D	4.12e-05	183	47	4	e37d2c015c34471a8a54a0299e94b0371e1ada5a
ToppCell	Control-Lymphoid-B\|Control / Disease state, Lineage and Cell class	CR2 JADE3 IGHE INPP5D	4.21e-05	184	47	4	de0294f879268bfd68e91adcc2adba211d221b7a
ToppCell	5'-Adult-LymphNode-Endothelial-blood_vessel_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SELP LAMA5 HSPG2 SASH1	4.77e-05	190	47	4	141266bf411ea675fbf889b20c1b08673c45ff95
ToppCell	COVID-19-kidney-Stressed_EC\|kidney / Disease (COVID-19 only), tissue and cell type	SELP HSPG2 SASH1 INPP5D	4.87e-05	191	47	4	d35aa842b813ea0eff7362abc894cca4e86b2fb2
ToppCell	Fibroblasts-CD55+_Fibroblasts\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	SELP ITGBL1 ANGPTL2 SASH1	5.07e-05	193	47	4	8f4bf9a2fbedae35432dad96730b00c70185874c
ToppCell	5'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SELP LAMA5 HSPG2 SASH1	5.07e-05	193	47	4	c0973a2c97deb7176c2f617c8760a55f7edc9839
ToppCell	Tracheal-NucSeq-Immune_Lymphocytic-B-B_cell-B_mature\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CR2 JADE3 IGHE INPP5D	5.60e-05	198	47	4	863765ccc0205dc28864dae85af339c283194c96
ToppCell	Tracheal-NucSeq-Immune_Lymphocytic-B-B_cell\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CR2 JADE3 IGHE INPP5D	5.60e-05	198	47	4	824461cf44098440ba8bc0df96735423ac65bda1
ToppCell	Fibroblasts\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	HSPG2 ITGBL1 ANGPTL2 SASH1	5.71e-05	199	47	4	40de6d4a31cf22efa2864f79e4ec8e2b7bfc9d4a
ToppCell	5'-Adult-SmallIntestine-Endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SELP LAMA5 HSPG2 SASH1	5.82e-05	200	47	4	2554b77edfe3d378296b0b25625caacbfb1c0e76
ToppCell	E16.5-samps-Myeloid-Macrophage-CD163+_Macrophage\|E16.5-samps / Age Group, Lineage, Cell class and subclass	CFHR2 SASH1 TG	5.09e-04	148	47	3	56e146980a71b5ca655118ae13310c5949220d4a
ToppCell	E16.5-samps-Myeloid-Macrophage\|E16.5-samps / Age Group, Lineage, Cell class and subclass	CFHR2 SASH1 TG	5.09e-04	148	47	3	cd5f697d8c2f272be1f3f52a05446749278431c5
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c06-NR4A2\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	TEPSIN STXBP5 PCNT	5.50e-04	152	47	3	5adcdf93fd3ca066402aaaf308c363e4648f871d
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c08-GZMK-FOS_h\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TEPSIN ARHGEF28 CEP57L1	5.93e-04	156	47	3	14e2f693a75f1075f40cc7b16ee430262a5de016
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	WT1 LAMA5 IL6R	6.15e-04	158	47	3	e7db0ee4740e3c7a4d97d7cd7462e2c2ab458a4b
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	WT1 LAMA5 IL6R	6.15e-04	158	47	3	d39e020c3e77eb9d3de600a171d22f94357061d4
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells-B_cells_L.1.5.0.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	WT1 IGHE LRP1B	6.61e-04	162	47	3	b46158e260bd2f35702cec73e3b035e8e9ec4469
ToppCell	Fetal_29-31_weeks-Immune-mast_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SELP STXBP5 INPP5D	6.73e-04	163	47	3	03b2ec226adffba3ce893f3d12e549c841e662fd
ToppCell	368C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	LAMA5 SASH1 LYPD5	7.10e-04	166	47	3	76b4cd32698900797ec009f17e50ea7ae36b85f4
ToppCell	5'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-cDC2\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CLEC7A IL6R INPP5D	7.10e-04	166	47	3	83d0c26ccee605df6b04bbca31661bf4ff4f22ba
ToppCell	368C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)\|368C / Donor, Lineage, Cell class and subclass (all cells)	LAMA5 SASH1 LYPD5	7.10e-04	166	47	3	30a991fc3275b571d53bd0976df4789e5d40b01d
ToppCell	facs-Kidney-nan-3m-Myeloid-macrophage\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLEC7A IL6R INPP5D	7.22e-04	167	47	3	991a93e1075d562b7391f0689b2f62c1351d48d1
ToppCell	facs-Kidney-nan-3m-Myeloid-macrophage\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLEC7A IL6R INPP5D	7.22e-04	167	47	3	934905aeaafbc215ec8f6a7903498b0e258b9220
ToppCell	facs-Kidney-nan-3m-Myeloid\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLEC7A IL6R INPP5D	7.22e-04	167	47	3	f22d1471c785b30d096ec5cdc68974e850ed7de0
ToppCell	facs-Heart-RV-3m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLEC7A IL6R INPP5D	7.35e-04	168	47	3	a405f0de70293f68b4e000c1fc8a9ad33d56539a
ToppCell	facs-Heart-RV-3m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLEC7A IL6R INPP5D	7.35e-04	168	47	3	8ee57814c7e9d45444f48b6b269c4d535bc4d5e1
ToppCell	facs-Heart-RV-3m-Myeloid\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLEC7A IL6R INPP5D	7.35e-04	168	47	3	c1a5f4f4d32a1f8583048db709a7037cc9357ad8
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLBP IL6R RECQL5	7.48e-04	169	47	3	16c52a0f6d96ecc1832922fce9b39691849f0d73
ToppCell	B_cell\|World / lung cells shred on cell class, cell subclass, sample id	CR2 IGHE INPP5D	7.61e-04	170	47	3	cec4090ba6a9c934d5f6f9e4aa7823f3713319b7
ToppCell	Children_(3_yrs)-Immune-B_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CR2 JADE3 INPP5D	7.61e-04	170	47	3	e421f9eedf74baffda1d03707a710ece4b777f29
ToppCell	droplet-Liver-LIVER-NPC-1m-Lymphocytic-macrophage/monocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ERI2 IL6R PCNT	7.61e-04	170	47	3	3ad9f950b87ee98f025ab9b4a8ed551e6a9b4764
ToppCell	TCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-8\|TCGA-Liver / Sample_Type by Project: Shred V9	CFHR2 CFHR4 CFHR3	7.74e-04	171	47	3	c4a919fe3d56ae6df2fcab6686abacc10befc053
ToppCell	390C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)\|390C / Donor, Lineage, Cell class and subclass (all cells)	LAMA5 SASH1 LYPD5	7.87e-04	172	47	3	6f302ed795767a9636081dc64373f8f039ea16d2
ToppCell	390C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-\|390C / Donor, Lineage, Cell class and subclass (all cells)	LAMA5 SASH1 LYPD5	7.87e-04	172	47	3	fd8097299fc05390b30afaa9e6c80b1f607c27aa
ToppCell	E12.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	HSPG2 MRNIP RECQL5	7.87e-04	172	47	3	3b9be685fcd1634498a603b692f5ac6ddd0de176
ToppCell	facs-Heart-RA-3m-Myeloid\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLEC7A IL6R INPP5D	8.00e-04	173	47	3	5058cb5e3f2d57dbe947e1b113eb2bef7bf6dd7d
ToppCell	facs-Heart-RA-3m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLEC7A IL6R INPP5D	8.00e-04	173	47	3	4fa5f502fa3ff8f888e279f68a0dafd91b37f26f
ToppCell	facs-Heart-RA-3m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLEC7A IL6R INPP5D	8.00e-04	173	47	3	ea406b47ff3ead992bc06f6b1707c76eee574782
ToppCell	facs-Heart-LA-3m-Myeloid\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLEC7A IL6R INPP5D	8.13e-04	174	47	3	30c083fe4711735e83dccfd00fcd746ae673d353
ToppCell	facs-Heart-LV-3m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLEC7A IL6R INPP5D	8.13e-04	174	47	3	dc8a238ec1d954bec0f8eb67c04a61734c96f5b5
ToppCell	5'-GW_trimst-2-LymphNode-Endothelial-blood_vessel_EC-Fetal_venous_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SELP HSPG2 TG	8.13e-04	174	47	3	6b5ff1cc5fe6705f7ea70b5a892dfbf91e32288d
ToppCell	facs-Heart-LV-3m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLEC7A IL6R INPP5D	8.13e-04	174	47	3	54166a0faf748cccb6406c2c268e1e6e21caf6d0
ToppCell	facs-Heart-LA-3m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLEC7A IL6R INPP5D	8.13e-04	174	47	3	46d19c1144fff19be682b7ba59d4c3e014f79e15
ToppCell	facs-Heart-LA-3m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLEC7A IL6R INPP5D	8.13e-04	174	47	3	1802a52552256d1e25d8b328ba62dcfe41671900
ToppCell	wk_15-18-Epithelial-Distal_epithelial-type_I_pneumocyte\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	CFHR1 LAMA5 HSPG2	8.13e-04	174	47	3	2cd6638b361ca05ab83d09ce657194aed97873b7
ToppCell	facs-Heart-LV-3m-Myeloid\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLEC7A IL6R INPP5D	8.27e-04	175	47	3	5d106ef542b97f97aeb19179e3f72963ead1e82a
ToppCell	368C-Endothelial_cells-Endothelial-D\|368C / Donor, Lineage, Cell class and subclass (all cells)	SELP LAMA5 HSPG2	8.27e-04	175	47	3	c4088b5f9fa145869cf5dd8bee7680b1c8fada42
ToppCell	368C-Endothelial_cells-Endothelial-D-\|368C / Donor, Lineage, Cell class and subclass (all cells)	SELP LAMA5 HSPG2	8.27e-04	175	47	3	ca0d3e3a0a271cccdd3881b055fecb626712478d
ToppCell	3'_v3-GI_small-bowel-Myeloid_Mac-Macrophage\|GI_small-bowel / Manually curated celltypes from each tissue	CLEC7A ARHGEF28 CFHR3	8.41e-04	176	47	3	4be270f6bb7da4070f972aca403109751646d155
ToppCell	facs-Skin-Anagen-24m-Epithelial-keratinocyte_stem_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRNIP ERI2 CEP57L1	8.55e-04	177	47	3	e9d7682517fb30fd2ad535d59779d718a7024c13
ToppCell	COVID-19-lung-B_cells\|lung / Disease (COVID-19 only), tissue and cell type	CR2 JADE3 INPP5D	8.55e-04	177	47	3	f54691e5558091c1734ab15153a10bff15ed171e
ToppCell	facs-Skin-Anagen-24m-Epithelial-actively_dividing_stem_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRNIP ERI2 CEP57L1	8.55e-04	177	47	3	8a0f0fbb06cdacb99a3fdba0da3e0494b891db4f
ToppCell	COVID-19-B_cells-Activated_B_cells\|COVID-19 / group, cell type (main and fine annotations)	CR2 JADE3 INPP5D	8.55e-04	177	47	3	653bb62a3744d4024ab3186ee01d410ed62832a6
ToppCell	COVID-19-kidney-Epi_(Mes)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	WT1 ARHGEF28 NTN3	8.69e-04	178	47	3	544379f5a6145429762258d426b876bb36c112f5
ToppCell	facs-GAT-Fat-3m-Lymphocytic-B_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CR2 VGLL2 INPP5D	8.69e-04	178	47	3	5b6f7e8a930c239db1f31edfb61b2b9228d28663
ToppCell	wk_15-18-Endothelial-Blood_vessel_endothelial-OMD+_endo\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	SELP HSPG2 ZNF541	8.83e-04	179	47	3	8c9ed247e1c4d655b81ce2f24a9936a7cade718a
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Hematopoietic\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CLEC7A IL6R INPP5D	8.83e-04	179	47	3	716856b2c7c660bf5ce00e63efeda6ed121f2baa
ToppCell	COVID-19-kidney-Stressed_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SELP SASH1 INPP5D	8.83e-04	179	47	3	754f69bac7a1d5137f5141f6193285ccbfe361cb
ToppCell	Children_(3_yrs)-Immune-B_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CR2 JADE3 INPP5D	8.97e-04	180	47	3	40a12eb852373ae3d7c8d9bca376b0ae99f724b3
ToppCell	PCW_05-06-Endothelial-Endothelial_mature-endo_arterial_(9)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	SELP HSPG2 INPP5D	8.97e-04	180	47	3	5861b44acfb8fe92c281c8355bf19c059b3dcd64
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_naive-B_naive-2\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	STRN4 CR2 CEP57L1	9.12e-04	181	47	3	75035a3211e524bb659b82e6979f7d3a3121ae70
ToppCell	10x5'-Liver-Lymphocytic_B-Memory_B_cells\|Liver / Manually curated celltypes from each tissue	CR2 JADE3 IGHE	9.12e-04	181	47	3	a9f4df288c34e3b2b6ed861ac6cda970c3ee08b1
ToppCell	5'-Adult-LymphNode-Mesenchymal-fibroblastic-Transitional_Stromal_3_(C3+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	WT1 LYPD5 CFHR3	9.12e-04	181	47	3	ab66a89f316b935d9ba1277426d976b1e9e39757
ToppCell	nucseq-Immune-Lymphocytic_B-Lymphocytic_B-B\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CR2 JADE3 INPP5D	9.12e-04	181	47	3	8d8cc4dae2c8bd5f4b1c159f2a52edc4c9449c86
ToppCell	droplet-Kidney-nan-3m-Mesenchymal-podocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGBL1 ANGPTL2 NTN3	9.12e-04	181	47	3	0b1e7335648823b1d83bdfa878ccd44efe7bba9a
ToppCell	facs-SCAT-Fat-18m-Lymphocytic-B_cell\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CR2 INPP5D TG	9.12e-04	181	47	3	3510e0ecd4f098e8553946c44c2a49587d543755
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L6_THEMIS_LINC00343\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ARHGEF28 LRP1B TG	9.26e-04	182	47	3	cc6f9d606a4f8717dc44928ceec2a257636043fd
ToppCell	cellseq-Immune-Lymphocytic_B-Lymphocytic_B-B\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CR2 IGHE INPP5D	9.26e-04	182	47	3	dc6b5ce410c1a7cade60ae17cbbe8548c088cba8
ToppCell	tumor_Lymph_Node_/_Brain-Endothelial_cells\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	SELP HSPG2 ANGPTL2	9.26e-04	182	47	3	d7cce5dd7046f06bf40f00c9dbfa610722b03333
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ARHGEF28 LRP1B TG	9.26e-04	182	47	3	35b2a5625323bf0917214d3b82fafc4a8f5e75ff
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC2_(MADCAM1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SELP CR2 ZNF541	9.26e-04	182	47	3	f231e86524b628e6e11ac33d5c34be99d454a92a
ToppCell	10x3'2.3-week_14-16-Endothelial-stroma-proliferating_EC\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	HSPG2 ARHGEF28 SASH1	9.26e-04	182	47	3	997d37ca2af661c92a56add888762724dfccc890
ToppCell	TCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical-1\|TCGA-Thryoid / Sample_Type by Project: Shred V9	WT1 CLEC7A ITGBL1	9.41e-04	183	47	3	06e4b05d86a7d643569e19575c2c9aa351d33f29
ToppCell	droplet-Thymus-nan-18m-Myeloid-Plasma_cells_and_B_cells\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AIRE NTN3 TG	9.41e-04	183	47	3	ffb1bbbccb34d1a7e99872611f497450039d5019
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-mesothelial_cell-Mesothelium\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	WT1 CFHR1 VGLL2	9.41e-04	183	47	3	03649492c37f9b274a1caf3e2132ce2915cf1df5
ToppCell	nucseq-Immune-Lymphocytic_B-Lymphocytic_B\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CR2 JADE3 INPP5D	9.56e-04	184	47	3	942b58ae7172bb5f97e55b032db9329d161854af
ToppCell	nucseq-Immune-Lymphocytic_B\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CR2 JADE3 INPP5D	9.56e-04	184	47	3	911658e7bb499c1bbc8419eec8ff88729bc39a75
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ARHGEF28 LRP1B TG	9.56e-04	184	47	3	9a185e6ea86bbfbb48bfe88650a8c05ceba78d7f
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-mesothelial_cell\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	WT1 CFHR1 VGLL2	9.56e-04	184	47	3	e0beb016823514eebdbfc13beb0807efb4470f08
ToppCell	COVID-19-Endothelial_cells-Arterial_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	SELP HSPG2 SASH1	9.56e-04	184	47	3	0f19494789f38ab1a420545e15e748ca7eb345c3
ToppCell	normal_Lung-Endothelial_cells-Tumor_ECs\|normal_Lung / Location, Cell class and cell subclass	SELP HSPG2 ANGPTL2	9.56e-04	184	47	3	7ee98acda030366ac6cf3890a6d93fd0426712ed
ToppCell	3'-Distal_airway-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ITGBL1 ANGPTL2 VGLL2	9.71e-04	185	47	3	7b1c5d99bd7a6e148524029758cee244a17f5d09
ToppCell	COVID-19-Endothelial_cells-Systemic_venous_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	SELP HSPG2 SASH1	9.71e-04	185	47	3	f5e14181f45c37d13ee9e017a4c8bc248c353676
ToppCell	3'-Distal_airway-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ITGBL1 ANGPTL2 VGLL2	9.71e-04	185	47	3	e9033a03d574956cf3ae228740b3166e40a6397f
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA5 HSPG2 ERI2	9.71e-04	185	47	3	bdd2e6cb20294b39a9d856004bf57ba69cf877e2
ToppCell	3'-Distal_airway-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ITGBL1 ANGPTL2 VGLL2	9.71e-04	185	47	3	578f12c6b2e33d09598dc8e022a20c8555d1325c
ToppCell	droplet-Lung-21m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	WT1 HSPG2 ITGBL1	9.86e-04	186	47	3	7c1807fca590cdccf7f5734460bac228d33964ca
ToppCell	tumor_Lung-B_lymphocytes\|tumor_Lung / Location, Cell class and cell subclass	CR2 IGHE INPP5D	9.86e-04	186	47	3	a54b368d7921185c583e35b532a6898c5486c2fc
ToppCell	Control-Endothelial-Endothelial-Vein\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SELP HSPG2 LRP1B	9.86e-04	186	47	3	92092f11ecce22c14f244e42c499af0822977e6f
ToppCell	droplet-Lung-1m-Endothelial-arterial_endothelial\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SELP HSPG2 ARHGEF28	9.86e-04	186	47	3	ffbc78058be8f0dc2e0335cc4c3195a636d17721
ToppCell	droplet-Lung-1m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SELP HSPG2 ARHGEF28	9.86e-04	186	47	3	ed924852cd7132c8f6703522037dc22bd2c83193
Drug	Acebutolol hydrochloride [34381-68-5]; Up 200; 10.8uM; MCF7; HT_HG-U133A	AIRE LAMA5 CFHR2 MRNIP ANGPTL2 BAZ2A	2.81e-06	198	46	6	1493_UP
Drug	1ct8	CFHR1 CFHR2 CFHR5 CFHR4 CFHR3	2.55e-05	173	46	5	CID000444888
Drug	Etiocobalamin	SELP CFHR2 CR2 CFHR4 CFHR3	2.84e-05	177	46	5	CID006450878
Drug	Josamycin [16846-24-5]; Up 200; 4.8uM; MCF7; HT_HG-U133A	AIRE CFHR2 MRNIP ANGPTL2 RECQL5	4.62e-05	196	46	5	5692_UP
Drug	Atropine sulfate monohydrate [5908-99-6]; Down 200; 5.8uM; PC3; HT_HG-U133A	LAMA5 HSPG2 MRNIP ASXL1 BAZ2A	4.74e-05	197	46	5	5865_DN
Drug	Ampyrone [83-07-8]; Up 200; 19.6uM; PC3; HT_HG-U133A	WT1 POM121L2 HSPG2 ANGPTL2 RECQL5	4.74e-05	197	46	5	4507_UP
Drug	Diltiazem hydrochloride [33286-22-5]; Up 200; 8.8uM; MCF7; HT_HG-U133A	AIRE POM121L2 NCOR1 BAZ2A IL6R	4.74e-05	197	46	5	1532_UP
Drug	Metolazone [17560-51-9]; Up 200; 11uM; PC3; HT_HG-U133A	CLEC7A NCOR1 BAZ2A RECQL5 TG	4.85e-05	198	46	5	6292_UP
Drug	LMWH	SELP CFHR1 LAMA5 CFHR2 HSPG2 CFHR5 CFHR4 CFHR3	4.86e-05	663	46	8	CID000000772
Drug	Bacampicillin hydrochloride [37661-08-8]; Down 200; 8uM; HL60; HT_HG-U133A	HSPG2 HEATR6 JADE3 IL6R RECQL5	4.97e-05	199	46	5	1337_DN
Disease	Complement deficiency disease	CFHR1 CFHR2 CFHR5 CFHR4 CFHR3	1.19e-09	33	43	5	C0272242
Disease	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial measurement	CFHR1 CFHR4 CFHR3	1.15e-08	4	43	3	EFO_0803292
Disease	Age related macular degeneration	CFHR1 CFHR2 CFHR4 CFHR3	1.04e-07	30	43	4	C0242383
Disease	Hemolytic-uremic syndrome	CFHR1 CFHR4 CFHR3	2.41e-07	9	43	3	cv:C0019061
Disease	C3 glomerulopathy	CFHR1 CFHR2 CFHR5	2.41e-07	9	43	3	C4087273
Disease	Atypical hemolytic-uremic syndrome	CFHR1 CFHR4 CFHR3	2.41e-07	9	43	3	cv:C2931788
Disease	complement factor H-related protein 5 measurement	CFHR1 CFHR2 CFHR5 CFHR4	4.20e-07	42	43	4	EFO_0008098
Disease	hemopexin measurement	CFHR1 CFHR5 CFHR4	4.72e-07	11	43	3	EFO_0008149
Disease	complement factor H-related protein 4 measurement	CFHR1 CFHR2 CFHR5 CFHR4	7.90e-07	49	43	4	EFO_0600091
Disease	complement factor H-related protein 1 measurement	CFHR1 CFHR2 CFHR5 CFHR4	1.36e-06	56	43	4	EFO_0600054
Disease	zinc finger protein 329 measurement	CFHR1 CFHR4	2.07e-06	2	43	2	EFO_0803276
Disease	leucine-rich repeat-containing protein 19 measurement	CFHR1 CFHR4	2.07e-06	2	43	2	EFO_0801762
Disease	CFHR5 DEFICIENCY	CFHR1 CFHR5	2.07e-06	2	43	2	C3553720
Disease	phosphopantothenoylcysteine decarboxylase measurement	CFHR1 CFHR4	2.07e-06	2	43	2	EFO_0802867
Disease	level of otoraplin in blood serum	CFHR1 CFHR4	2.07e-06	2	43	2	OBA_2042720
Disease	flap endonuclease 1 measurement	CFHR1 CFHR3	2.07e-06	2	43	2	EFO_0802551
Disease	protein FAM209B measurement	CFHR1 CFHR4	2.07e-06	2	43	2	EFO_0802943
Disease	complement factor H-related protein 3 measurement	CFHR1 CFHR2 CFHR5 CFHR4 CFHR3	4.69e-06	169	43	5	EFO_0600056
Disease	level of alpha-N-acetylglucosaminidase in blood serum	CFHR1 CFHR4	6.22e-06	3	43	2	OBA_2042500
Disease	anaphase-promoting complex subunit 7 measurement	CFHR1 CFHR3	6.22e-06	3	43	2	EFO_0801381
Disease	soluble transferrin receptor measurement	CFHR1 CFHR4	6.22e-06	3	43	2	EFO_0004460
Disease	HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 1	CFHR1 CFHR3	6.22e-06	3	43	2	C2749604
Disease	HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 1	CFHR1 CFHR3	6.22e-06	3	43	2	235400
Disease	calnexin measurement	CFHR1 CFHR4	6.22e-06	3	43	2	EFO_0801444
Disease	histone-lysine N-methyltransferase 2D measurement	CFHR1 CFHR4	6.22e-06	3	43	2	EFO_0801683
Disease	complement factor H-related protein 4A measurement	CFHR1 CFHR4	6.22e-06	3	43	2	EFO_0600057
Disease	Hemolytic uremic syndrome, atypical, susceptibility to, 1	CFHR1 CFHR3	6.22e-06	3	43	2	cv:C2749604
Disease	complement factor H-related protein 2 measurement	CFHR1 CFHR2 CFHR4	1.03e-05	29	43	3	EFO_0600055
Disease	age related macular degeneration 1 (is_implicated_in)	CFHR1 CFHR3	1.24e-05	4	43	2	DOID:0110014 (is_implicated_in)
Disease	kallikrein-5 measurement	CFHR1 CFHR4	1.24e-05	4	43	2	EFO_0020515
Disease	Macular Degeneration, Age-Related, 1	CFHR1 CFHR3	1.24e-05	4	43	2	C1864205
Disease	MACULAR DEGENERATION, AGE-RELATED, 1	CFHR1 CFHR3	1.24e-05	4	43	2	603075
Disease	Age related macular degeneration 1	CFHR1 CFHR3	1.24e-05	4	43	2	cv:C1864205
Disease	Recurrent infections	CR2 IL6R	2.07e-05	5	43	2	C0239998
Disease	complement factor H measurement	CFHR1 CFHR2 CFHR4	2.96e-05	41	43	3	EFO_0008097
Disease	complement C1s subcomponent measurement	CFHR1 CFHR4	3.10e-05	6	43	2	EFO_0008091
Disease	DNA repair protein XRCC4 measurement	CFHR1 CFHR4	5.78e-05	8	43	2	EFO_0801532
Disease	atypical hemolytic-uremic syndrome (is_implicated_in)	CFHR1 CFHR3	5.78e-05	8	43	2	DOID:0080301 (is_implicated_in)
Disease	infection	INPP5D ZNF541	7.42e-05	9	43	2	EFO_0000544
Disease	leukocyte immunoglobulin-like receptor subfamily A member 5 measurement	CFHR1 CFHR4	7.42e-05	9	43	2	EFO_0801766
Disease	Atypical Hemolytic Uremic Syndrome	CFHR1 CFHR3	9.27e-05	10	43	2	C2931788
Disease	atrophic macular degeneration, age-related macular degeneration, wet macular degeneration	CFHR1 CFHR5 CFHR4	9.31e-05	60	43	3	EFO_0001365, EFO_0004683, EFO_1001492
Disease	Graves' disease (is_marker_for)	IL6R TG	2.15e-04	15	43	2	DOID:12361 (is_marker_for)
Disease	age-related macular degeneration	CFHR1 CFHR5 CFHR4	3.00e-04	89	43	3	EFO_0001365
Disease	Age-related macular degeneration	CFHR1 CFHR3	3.13e-04	18	43	2	cv:C0242383
Disease	coagulation factor measurement	CFHR5 CFHR4	3.88e-04	20	43	2	EFO_0004634
Disease	severe acute respiratory syndrome, COVID-19	SLBP ARHGEF28 LRP1B INPP5D TG	4.67e-04	447	43	5	EFO_0000694, MONDO_0100096
Disease	sleep quality	SASH1 LRP1B VGLL2	6.85e-04	118	43	3	EFO_0005272
Disease	Myeloid Leukemia, Chronic	WT1 ASXL1	8.21e-04	29	43	2	C0023473
Disease	Bilateral Wilms Tumor	WT1 ASXL1	8.21e-04	29	43	2	C2930471
Disease	IGA Glomerulonephritis	CFHR1 CFHR3	1.13e-03	34	43	2	C0017661
Disease	Nephroblastoma	WT1 ASXL1	1.27e-03	36	43	2	C0027708
Disease	human immunodeficiency virus infectious disease (is_marker_for)	SELP CR2	1.27e-03	36	43	2	DOID:526 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
SWSTGCKLPASPRRV	CASTOR3	16	Q8NAP1
DCSPVRSSSWRRLPS	ERI2	561	A8K979
RGWTCPSPDSTREDL	BAZ2A	1536	Q9UIF9
SSTDKPSGPWRDCLQ	ANGPTL2	266	Q9UKU9
RIIPTTESSCRGWTG	ASXL1	596	Q8IXJ9
PLREIPSGTWRCSSC	AIRE	326	O43918
KSLEPRPWSSTDSDG	R3HDM2	321	Q9Y2K5
RCSATGSPTPTLEWT	HSPG2	1886	P98160
KWSRSTVQPPCSRGV	MRNIP	151	Q6NTE8
PVTSGSERPCGKTSW	MRNIP	291	Q6NTE8
SERPCGKTSWDARTP	MRNIP	296	Q6NTE8
SPESRGCTLWPQSSK	ARHGEF28	401	Q8N1W1
ASQKRSSTGRPDWTC	RAB3GAP2	141	Q9H2M9
WSGTQCERPAPKSSK	LRP1B	4421	Q9NZR2
ERGWSTPPKCRSTIS	CFHR2	131	P36980
VSSPKGSSEPCWLIR	HEATR6	641	Q6AI08
PKRGPSSCAWSRDSL	TEPSIN	456	Q96N21
TTPWGRKTPACISEL	PRR25	76	Q96S07
DRPCARSKSTGDPWL	LAMA5	2926	O15230
KGCSPSRSERSAWKP	PCNT	3086	O95613
GTASPLCWRSESLPR	NTN3	86	O00634
TVTCTEKGWSPTPRC	CFHR3	126	Q02985
VCEWGPRSTPSLTTK	IL6R	131	P08887
KTGTWSGPAPRCELS	CR2	331	P20023
DGWSPTVPCLRTCSK	CFHR4	76	Q92496
TCTEEGWSPTPKCLR	CFHR5	71	Q9BXR6
ERGWSTPPICSFTKG	CFHR5	131	Q9BXR6
TPEWPGSRDKRTLAC	IGHE	331	P01854
RWSATPPTCKGIASL	SELP	621	P16109
RPSCTTEGTTSPWTA	LYPD5	186	Q6UWN5
TETRCLPKPSRTTSW	CEP57L1	291	Q8IYX8
TCTEEGWSPTPKCLR	CFHR1	71	Q03591
ERGWSTPPKCRSTDT	CFHR1	131	Q03591
PEWPRRASCTSSTSG	GYS1	691	P13807
DITPWESKRRCTSPD	ITGBL1	221	O95965
AKESSPAWRTPSSEC	JADE3	616	Q92613
TTPEGPKPRSRCSDW	SLBP	61	Q14493
PKPRSRCSDWASAVE	SLBP	66	Q14493
TSPCGTSKSPNREWE	NCOR1	991	O75376
PSPSWSGSCRRSLLS	SENP1	156	Q9P0U3
KQWEVTSRAPPCSGS	INPP5D	891	Q92835
PPTCSLVGRTWQSRT	SPATA31E1	961	Q6ZUB1
KTDSSPSPCLWVGTT	STXBP5	806	Q5T5C0
SSCRNFSDPWKRSVP	POM121L2	261	Q96KW2
VSEKGSCAASPPWRL	CLEC7A	31	Q9BXN2
ALERSSSWSKTCIGP	RECQL5	446	O94762
SCTSSKAPRSSGPWR	VGLL2	116	Q8N8G2
TGKTSEKPFSCRWPS	WT1	406	P19544
RKPVSPGCISSVSDW	SASH1	1171	O94885
GTVRIWDPSSSSPAC	STRN4	566	Q9NRL3
IPCRSTKGRWPLTAS	TP53TG3	101	Q9ULZ0
DASKPRASCWQPGTR	TG	2256	P01266
RASCWQPGTRTSTSP	TG	2261	P01266
GSPTDWTKPRSTFVC	ZNF541	826	Q9H0D2