Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentextracellular matrix

ADAMTS20 ADAMTSL1 ADAM11 SSPOP OTOGL FBN3

1.95e-04656286GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

ADAMTS20 ADAMTSL1 ADAM11 SSPOP OTOGL FBN3

1.98e-04658286GO:0030312
DomainEGF_3

ADAM11 CELSR3 SSPOP FBN3 HYAL3 CRB2

1.11e-06235286PS50026
DomainEGF_1

ADAM11 CELSR3 SSPOP FBN3 HYAL3 CRB2

1.79e-06255286PS00022
DomainEGF_2

ADAM11 CELSR3 SSPOP FBN3 HYAL3 CRB2

2.23e-06265286PS01186
DomainEGF

ADAM11 CELSR3 FBN3 HYAL3 CRB2

2.34e-05235285SM00181
DomainEGF-like_dom

ADAM11 CELSR3 FBN3 HYAL3 CRB2

3.09e-05249285IPR000742
DomainEGF-like_CS

ADAM11 CELSR3 FBN3 HYAL3 CRB2

3.87e-05261285IPR013032
DomainTSP_1

ADAMTS20 ADAMTSL1 SSPOP

1.13e-0463283PF00090
DomainTSP1

ADAMTS20 ADAMTSL1 SSPOP

1.24e-0465283SM00209
DomainTSP1_rpt

ADAMTS20 ADAMTSL1 SSPOP

1.24e-0465283IPR000884
DomainTSP1

ADAMTS20 ADAMTSL1 SSPOP

1.24e-0465283PS50092
DomainASX_HYDROXYL

CELSR3 FBN3 CRB2

4.43e-04100283PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

CELSR3 FBN3 CRB2

5.25e-04106283IPR000152
DomainPeptidase_M12B_ADAM-TS

ADAMTS20 ADAMTSL1

5.86e-0424282IPR013273
DomainEGF_CA

CELSR3 FBN3 CRB2

7.91e-04122283SM00179
DomainhEGF

FBN3 CRB2

8.00e-0428282PF12661
DomainEGF-like_Ca-bd_dom

CELSR3 FBN3 CRB2

8.29e-04124283IPR001881
DomainEGF

CELSR3 FBN3 CRB2

8.68e-04126283PF00008
DomainZnf_C2H2-like

ZNF133 ZNF276 ZNF853 ZNF649 GFI1 RNF138

9.90e-04796286IPR015880
DomainZnf_C2H2

ZNF133 ZNF276 ZNF853 ZNF649 GFI1 RNF138

1.05e-03805286IPR007087
DomainZnF_C2H2

ZNF133 ZNF276 ZNF853 ZNF649 GFI1 RNF138

1.07e-03808286SM00355
DomainLAM_G_DOMAIN

CELSR3 CRB2

1.47e-0338282PS50025
DomainPeptidase_M12B_N

ADAMTS20 ADAM11

1.55e-0339282IPR002870
DomainPep_M12B_propep

ADAMTS20 ADAM11

1.55e-0339282PF01562
DomainDISINTEGRIN_1

ADAMTS20 ADAM11

1.63e-0340282PS00427
DomainLaminin_G_2

CELSR3 CRB2

1.63e-0340282PF02210
DomainADAM_MEPRO

ADAMTS20 ADAM11

1.63e-0340282PS50215
DomainDISINTEGRIN_2

ADAMTS20 ADAM11

1.63e-0340282PS50214
DomainReprolysin

ADAMTS20 ADAM11

1.63e-0340282PF01421
DomainPeptidase_M12B

ADAMTS20 ADAM11

1.63e-0340282IPR001590
DomainDisintegrin_dom

ADAMTS20 ADAM11

1.71e-0341282IPR001762
DomainLamG

CELSR3 CRB2

1.97e-0344282SM00282
Domain-

ZNF133 ZNF276 ZNF853 ZNF649 GFI1

3.07e-036792853.30.160.60
Domainzf-C2H2

ZNF133 ZNF276 ZNF853 ZNF649 GFI1

3.35e-03693285PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF133 ZNF276 ZNF853 ZNF649 GFI1

3.37e-03694285IPR013087
DomainLaminin_G

CELSR3 CRB2

3.40e-0358282IPR001791
DomainZINC_FINGER_C2H2_2

ZNF133 ZNF276 ZNF853 ZNF649 GFI1

5.39e-03775285PS50157
DomainZINC_FINGER_C2H2_1

ZNF133 ZNF276 ZNF853 ZNF649 GFI1

5.45e-03777285PS00028
DomainMetalloPept_cat_dom

ADAMTS20 ADAM11

6.53e-0381282IPR024079
Domain-

ADAMTS20 ADAM11

6.53e-03812823.40.390.10
Domain-

CELSR3 CRB2

8.88e-03952822.60.120.200
DomainZF_RING_1

TRAF7 TRIM71 RNF138

9.19e-03291283PS00518
DomainEGF_Ca-bd_CS

FBN3 CRB2

9.24e-0397282IPR018097
PathwayREACTOME_O_LINKED_GLYCOSYLATION

ADAMTS20 GALNT10 ADAMTSL1 SSPOP

5.17e-05109274MM15164
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTS20 ADAMTSL1 SSPOP

5.47e-0539273M27417
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTS20 ADAMTSL1 SSPOP

5.47e-0539273MM15165
PathwayREACTOME_O_LINKED_GLYCOSYLATION

ADAMTS20 GALNT10 ADAMTSL1 SSPOP

5.56e-05111274M27416
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

ADAMTS20 ADAMTSL1 SSPOP

2.89e-0468273M27303
PathwayWP_COMPLEMENT_SYSTEM_IN_NEURONAL_DEVELOPMENT_AND_PLASTICITY

PARD6B ITGAX CRB2

1.06e-03106273M42535
Pubmed

Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury.

ADAMTS20 ADAM11 SSPOP

2.10e-056429322261194
Pubmed

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.

ADAMTS20 ADAMTSL1 SSPOP

3.38e-057529320637190
Pubmed

Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes.

ADAMTSL1 ADAM11 FBN3

4.75e-058429315203218
Pubmed

Transcription factor Emx2 controls stereociliary bundle orientation of sensory hair cells.

PARD6B GFI1

6.07e-051429228266911
Pubmed

Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus.

CELSR3 SSPOP

7.00e-051529220473291
Pubmed

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.

ZNF276 SSPOP GFI1 POLR1H RNF138

1.35e-0460829516713569
Pubmed

EMX2-GPR156-Gαi reverses hair cell orientation in mechanosensory epithelia.

PARD6B GFI1

1.53e-042229234001891
Pubmed

Cul3-KLHL20 E3 ubiquitin ligase plays a key role in the arms race between HIV-1 Nef and host SERINC5 restriction.

TRAF7 RNF138

2.50e-042829235474067
Pubmed

Galnt1 is required for normal heart valve development and cardiac function.

ADAMTS20 GALNT10

4.16e-043629225615642
Pubmed

Mapping of transcription start sites of human retina expressed genes.

RPGR CRB2

6.50e-044529217286855
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF133 ZNF276 ZNF853 ZNF649 GFI1

1.17e-0371821528
GeneFamilyRing finger proteins

TRAF7 TRIM71 RNF138

3.78e-0327521358
ToppCellPCW_13-14-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

PARD6B TRIM71 ADAMTSL1 FBN3

6.46e-061882940d86044bc340e3efb90d0022dd299873639d831c
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Macroglial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF276 SSPOP NFRKB

9.73e-05138293c1a46fbf1beffa12c3d1b78361e0613e2e9e2d13
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Macroglial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF276 SSPOP NFRKB

1.06e-0414229367d4ff3483ae34f77c3325aa0fbd3462ca19ade4
ToppCellIIH-CD4-CD8_1|IIH / Condition, Cell_class and T cell subcluster

ZNF133 ADAM11 GFI1

1.13e-04145293296b6b0eea3233d76742ea35252b2f54d4c27ab6
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Macroglial-oligodendrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF276 SSPOP NFRKB

1.25e-04150293afd651c654e715414eff64cf3a37378d057a56a2
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4|368C / Donor, Lineage, Cell class and subclass (all cells)

CELSR3 GFI1 HYAL3

1.25e-04150293c843bcf98c5fad2ca4339602f721f3fb782ae353
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

TRIM71 SSPOP GFI1

1.51e-041602930f15f895f11dcabb73df79b26bfc4947f38435a7
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC-NK_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

TRIM71 SSPOP GFI1

1.51e-0416029350d4f867d021abcfeb49e6812bcfd5bb57466a31
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c01-FCGR3A|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

TRIM71 SSPOP GFI1

1.51e-041602937d004bfe42707605b3851cb2319126acda4d4802
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-plasmacytoid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PARD6B ADAM11 ITGAX

1.53e-04161293ed93cb6c133855a5c244821e1a260aae8ab4df9a
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-Plasmacytoid_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PARD6B ADAM11 ITGAX

1.53e-041612930089d7bb305c592392791862a3341fc92af8f3e2
ToppCellfacs-Thymus-nan-3m-Myeloid-macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM11 ALPK1 ITGAX

1.74e-04168293d72cd8238fa793bb3e4add4c59eaaaadcea9930d
ToppCell367C-Lymphocytic-ILC-ILC-1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

PARD6B TRAF7 ITGAX

1.74e-0416829380233a13135fd159f5764336a1fe67fba237776b
ToppCellfacs-Thymus-nan-3m-Myeloid|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM11 ALPK1 ITGAX

1.74e-04168293d2afc097ae1243574210be6a751685f949ea941a
ToppCellfacs-Thymus-nan-3m-Myeloid-macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM11 ALPK1 ITGAX

1.74e-04168293c34c52165485f612add7a3e35a175d5a6e365e7c
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTSL1 ALPK1 GRM4

1.74e-041682937abaddbcc55e44653d54aa15464266aa6bd5c9d2
ToppCell3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-mesothelial_cell-Mesothelium|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PARD6B OTOGL CRB2

1.77e-041692936937c46b119d4ce382fc8c2fa5925ede5ae89c81
ToppCell3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-mesothelial_cell|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PARD6B OTOGL CRB2

1.77e-041692930cece9b2bb1f58e465c20ec8735a4fc3c1021f03
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C_(NP)-Glut_NP_L5/6_FEZF2-Exc_L5-6_FEZF2_MYBPHL|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GALNT10 ADAMTSL1 GRM4

1.83e-041712930417fa805ca0acb7e9f6a30bc7b6bdbaba77844d
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Lymphocytic-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS20 ADAM11 GFI1

1.93e-041742936987fe7959afce347282f632abc16d800ccab7c4
ToppCellThalamus-Neuronal-Excitatory|Thalamus / BrainAtlas - Mouse McCarroll V32

ADAM11 CELSR3 GRM4

2.00e-04176293d2bbf13d21fb7582d7e5f90cd61a4ebe1cfccd66
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

TRIM71 ADAMTSL1 FBN3

2.10e-04179293815b959ce8721c5ded70c0ca6e318dafc691746e
ToppCellPericytes-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

ADAMTSL1 ARHGEF25 OTOGL

2.20e-0418229346c213597445b1f4f09dc367f27702d24b201daf
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTSL1 ALPK1 GRM4

2.24e-0418329365f2a5895d166189a095cf7ea9dda171f0419b08
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS20 SSPOP OTOGL

2.27e-04184293ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS20 SSPOP OTOGL

2.27e-041842932cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS20 SSPOP OTOGL

2.27e-041842932b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PARD6B ADAMTSL1 FBN3

2.27e-0418429329c95b814a0b1ad8734ed68b77df29c08594e5ec
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

TRIM71 ADAMTSL1 FBN3

2.35e-041862932ea5ff14861e5f91d0e6a5767c403a24045d715c
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PARD6B ADAMTSL1 FBN3

2.42e-04188293eea652bab161f19148a883e7e3fe2523b36b3cea
ToppCellPCW_10-12-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

PARD6B TRIM71 ADAMTSL1

2.42e-04188293beb2df2332a46cc81b10e8e29fc9829020111f03
ToppCelldroplet-Marrow-BM-1m-Lymphocytic-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM11 TOP3B GFI1

2.54e-041912934187f31ec399b4c7c3608e94e3c32b7a54b1c3d4
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

TRIM71 ADAMTSL1 FBN3

2.54e-04191293ca5669bd6f4a17471acae3eb229f845cc2e08efa
ToppCellEpithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|World / Lineage, Cell type, age group and donor

TRIM71 ADAMTSL1 FBN3

2.54e-04191293d3733c8c4bda70c4390e5601fdda6188a64be944
ToppCelldroplet-Marrow-BM-1m-Lymphocytic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM11 TOP3B GFI1

2.54e-041912938e8bc200524a44ebe132f823ab7c15dac65d4952
ToppCellFetal_29-31_weeks-Epithelial|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PARD6B ADAMTSL1 FBN3

2.62e-04193293a0ca3231992f14abcf1a6129573bace320e89d2a
ToppCellwk_15-18-Epithelial-Distal_epithelial-type_II_pneumocyte|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

PARD6B ADAMTSL1 FBN3

2.70e-041952930e3aac1b1a1fd483f5fb9a394eb90c0e1ce63542
ToppCellmLN-Dendritic_cell-cDC2|Dendritic_cell / Region, Cell class and subclass

GALNT10 ALPK1 ITGAX

2.90e-04200293e3f7852aaa26a9b3e626d85e40afde799e873045
ToppCellBrain_organoid-organoid_Tanaka_cellReport-6m-Mesenchymal-BMP_responsible_cell|6m / Sample Type, Dataset, Time_group, and Cell type.

PARD6B GALNT10 RPGR

2.90e-042002935fb90118d3abc28d72bc483e68317255090a04c7
Diseaseeosinophil measurement

GFI1 HYAL3

5.05e-03108292EFO_0803540
Diseasekeratinocyte carcinoma

PARD6B ZNF276

6.00e-03118292EFO_0010176
Diseaselifestyle measurement, maximum cigarettes per day measurement

ADAMTSL1 RNF138

6.40e-03122292EFO_0009264, EFO_0010724
Diseasemelanoma

ZNF276 MTAP

6.81e-03126292EFO_0000756

Protein segments in the cluster

PeptideGeneStartEntry
MRGGHKGGRCACPRV

ARHGEF25

1

Q86VW2
HAMHRDLCPGRVGLC

GRM4

421

Q14833
TCPGSGERRICSHHG

ADAM11

676

O75078
MVGSFHCRCPVGHRL

FBN3

266

Q75N90
VCDQGHCTNMPGGHR

FBN3

1206

Q75N90
GTDCGPGMHCRHGLC

ADAMTS20

531

P59510
MDVPCTNGHGSHRLC

ALPK1

861

Q96QP1
DGSHSCARGVCHIPM

MTAP

126

Q13126
LACGPTVHHECGRNM

ITGAX

106

P20702
MNRSHRHGAGSGCLG

PARD6B

1

Q9BYG5
PICRECTMGRHGGHS

TRIM71

296

Q2Q1W2
PCGDGHGTRIMEDCL

NFRKB

16

Q6P4R8
RSHSGTRPFACEMCG

GFI1

276

Q99684
MEPRGCATQPCHHGA

CRB2

66

Q5IJ48
CGGRMEDIPCSRVGH

GALNT10

356

Q86SR1
VLCIDHRGMHTGGCS

ADAMTSL1

461

Q8N6G6
CHGHGRCARRDPGQM

HYAL3

361

O43820
GHHCEHRMDQQCPRG

CELSR3

2016

Q9NYQ7
EDHRGRMVKHQCCPG

EHMT1

576

Q9H9B1
ISGCVCAPGMAEHRG

OTOGL

886

Q3ZCN5
CGGCHMVVFAAPHRG

RPGR

356

Q92834
PCGGGTMERHRTCEG

SSPOP

4781

A2VEC9
AMRESGAHCPLCRGN

RNF138

46

Q8WVD3
RCPRCGHEGMAYHTR

POLR1H

86

Q9P1U0
AASCHPMHRGGPGRR

TOP3B

816

O95985
GRALAMGHCRLCHGK

ZNF276

71

Q8N554
IHCRHGCRVAGSGKP

TRAF7

186

Q6Q0C0
RTHSGEKPMVCGECG

ZNF133

486

P52736
THTGERPHRCGECGK

ZNF853

506

P0CG23
RAHRGEKPHGCSLCG

ZNF649

226

Q9BS31