Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	iron-responsive element binding	IREB2 ACO1	7.94e-06	3	33	2	GO:0030350
GeneOntologyMolecularFunction	aconitate hydratase activity	IREB2 ACO1	7.94e-06	3	33	2	GO:0003994
GeneOntologyMolecularFunction	hydro-lyase activity	IREB2 FASN ACO1	1.53e-04	63	33	3	GO:0016836
GeneOntologyMolecularFunction	carbon-oxygen lyase activity	IREB2 FASN ACO1	3.33e-04	82	33	3	GO:0016835
GeneOntologyMolecularFunction	protein-disulfide reductase activity	SCO2 TXNDC5	1.61e-03	36	33	2	GO:0015035
GeneOntologyMolecularFunction	disulfide oxidoreductase activity	SCO2 TXNDC5	2.29e-03	43	33	2	GO:0015036
GeneOntologyMolecularFunction	4 iron, 4 sulfur cluster binding	IREB2 ACO1	2.73e-03	47	33	2	GO:0051539
GeneOntologyMolecularFunction	oxidoreductase activity, acting on a sulfur group of donors	SCO2 TXNDC5	3.99e-03	57	33	2	GO:0016667
GeneOntologyMolecularFunction	lyase activity	IREB2 FASN ACO1	5.09e-03	212	33	3	GO:0016829
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	SLC34A3 SLC25A28 RYR1 PKD1	6.96e-03	465	33	4	GO:0046873
GeneOntologyMolecularFunction	iron-sulfur cluster binding	IREB2 ACO1	7.35e-03	78	33	2	GO:0051536
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	CLDN4 SLC34A3 SLC25A28 RYR1 PKD1	7.64e-03	758	33	5	GO:0015318
GeneOntologyMolecularFunction	collagen binding	HSD17B12 ACHE	7.91e-03	81	33	2	GO:0005518
GeneOntologyMolecularFunction	metal cluster binding	IREB2 ACO1	8.29e-03	83	33	2	GO:0051540
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	CLDN4 SLC34A3 SLC25A28 RYR1 PKD1	9.20e-03	793	33	5	GO:0015075
GeneOntologyBiologicalProcess	citrate metabolic process	IREB2 ACO1	2.47e-05	5	33	2	GO:0006101
Domain	Aconitase/IRP2	IREB2 ACO1	2.49e-06	2	30	2	IPR006249
Domain	-	IREB2 ACO1	7.48e-06	3	30	2	3.40.1060.10
Domain	-	IREB2 ACO1	7.48e-06	3	30	2	3.20.19.10
Domain	Acoase/IPM_deHydtase	IREB2 ACO1	7.48e-06	3	30	2	IPR015937
Domain	Acnase/IPM_dHydase_lsu_aba_1/3	IREB2 ACO1	7.48e-06	3	30	2	IPR015931
Domain	Aconitase/IPMdHydase_lsu_aba_2	IREB2 ACO1	7.48e-06	3	30	2	IPR015932
Domain	AconitaseA/IPMdHydase_ssu_swvl	IREB2 ACO1	7.48e-06	3	30	2	IPR000573
Domain	ACONITASE_1	IREB2 ACO1	7.48e-06	3	30	2	PS00450
Domain	Aconitase/3IPM_dehydase_swvl	IREB2 ACO1	7.48e-06	3	30	2	IPR015928
Domain	ACONITASE_2	IREB2 ACO1	7.48e-06	3	30	2	PS01244
Domain	Acoase/IPM_deHydtase_lsu_aba	IREB2 ACO1	7.48e-06	3	30	2	IPR001030
Domain	Aconitase_C	IREB2 ACO1	7.48e-06	3	30	2	PF00694
Domain	Aconitase	IREB2 ACO1	7.48e-06	3	30	2	PF00330
Domain	Aconitase_4Fe-4S_BS	IREB2 ACO1	7.48e-06	3	30	2	IPR018136
Domain	-	IREB2 ACO1	7.48e-06	3	30	2	3.30.499.10
Domain	Claudin_CS	CLDN4 CLDN6	5.65e-04	22	30	2	IPR017974
Domain	CLAUDIN	CLDN4 CLDN6	5.65e-04	22	30	2	PS01346
Domain	Claudin	CLDN4 CLDN6	9.19e-04	28	30	2	IPR006187
Domain	PMP22_Claudin	CLDN4 CLDN6	1.87e-03	40	30	2	PF00822
Domain	Thioredoxin_domain	SCO2 TXNDC5	1.97e-03	41	30	2	IPR013766
Domain	THIOREDOXIN_2	SCO2 TXNDC5	2.16e-03	43	30	2	PS51352
Domain	PMP22/EMP/MP20/Claudin	CLDN4 CLDN6	2.37e-03	45	30	2	IPR004031
Domain	adh_short	HSD17B12 FASN	3.51e-03	55	30	2	PF00106
Pathway	WP_IRON_METABOLISM_IN_PLACENTA	IREB2 ACO1	1.81e-04	12	24	2	M39660
Pubmed	Subcellular localization of iron regulatory proteins to Golgi and ER membranes.	IREB2 ACO1	9.28e-07	2	34	2	16144863
Pubmed	Iron regulatory proteins secure mitochondrial iron sufficiency and function.	IREB2 ACO1	9.28e-07	2	34	2	20674864
Pubmed	Excess capacity of the iron regulatory protein system.	IREB2 ACO1	9.28e-07	2	34	2	17604281
Pubmed	Electron tomography of degenerating neurons in mice with abnormal regulation of iron metabolism.	IREB2 ACO1	9.28e-07	2	34	2	15866737
Pubmed	Tight junctions containing claudin 4 and 6 are essential for blastocyst formation in preimplantation mouse embryos.	CLDN4 CLDN6	9.28e-07	2	34	2	17980358
Pubmed	A regulated RNA binding protein also possesses aconitase activity.	IREB2 ACO1	9.28e-07	2	34	2	1946430
Pubmed	Generation of conditional alleles of the murine Iron Regulatory Protein (IRP)-1 and -2 genes.	IREB2 ACO1	9.28e-07	2	34	2	16283625
Pubmed	Iron regulatory proteins 1 and 2 have opposing roles in regulating inflammation in bacterial orchitis.	IREB2 ACO1	9.28e-07	2	34	2	38301068
Pubmed	Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis.	IREB2 ACO1	9.28e-07	2	34	2	14726953
Pubmed	Cloning of the cDNA encoding an RNA regulatory protein--the human iron-responsive element-binding protein.	IREB2 ACO1	9.28e-07	2	34	2	2172968
Pubmed	Effect of hypoxia on the binding and subcellular distribution of iron regulatory proteins.	IREB2 ACO1	9.28e-07	2	34	2	17200797
Pubmed	Genetic polymorphism of the iron-regulatory protein-1 and -2 genes in age-related macular degeneration.	IREB2 ACO1	9.28e-07	2	34	2	22331484
Pubmed	Molecular characterization of a second iron-responsive element binding protein, iron regulatory protein 2. Structure, function, and post-translational regulation.	IREB2 ACO1	9.28e-07	2	34	2	7983023
Pubmed	In vivo role(s) of the iron regulatory proteins (IRP) 1 and 2 in aseptic local inflammation.	IREB2 ACO1	9.28e-07	2	34	2	19533074
Pubmed	Microcytic anemia, erythropoietic protoporphyria, and neurodegeneration in mice with targeted deletion of iron-regulatory protein 2.	IREB2 ACO1	9.28e-07	2	34	2	15831703
Pubmed	Iron misregulation and neurodegenerative disease in mouse models that lack iron regulatory proteins.	IREB2 ACO1	9.28e-07	2	34	2	25771171
Pubmed	Targeted mutagenesis of the murine IRP1 and IRP2 genes reveals context-dependent RNA processing differences in vivo.	IREB2 ACO1	9.28e-07	2	34	2	15208438
Pubmed	Iron regulatory proteins increase neuronal vulnerability to hydrogen peroxide.	IREB2 ACO1	9.28e-07	2	34	2	18655771
Pubmed	Characterization of a second RNA-binding protein in rodents with specificity for iron-responsive elements.	IREB2 ACO1	9.28e-07	2	34	2	8262972
Pubmed	Effects of iron regulatory protein regulation on iron homeostasis during hypoxia.	IREB2 ACO1	9.28e-07	2	34	2	12855587
Pubmed	Iron regulatory proteins 1 and 2 in human monocytes, macrophages and duodenum: expression and regulation in hereditary hemochromatosis and iron deficiency.	IREB2 ACO1	9.28e-07	2	34	2	16503547
Pubmed	Iron regulatory protein 1 outcompetes iron regulatory protein 2 in regulating cellular iron homeostasis in response to nitric oxide.	IREB2 ACO1	9.28e-07	2	34	2	21566147
Pubmed	Mammalian tissue oxygen levels modulate iron-regulatory protein activities in vivo.	IREB2 ACO1	9.28e-07	2	34	2	15604406
Pubmed	Self-association and ligand-induced conformational changes of iron regulatory proteins 1 and 2.	IREB2 ACO1	9.28e-07	2	34	2	15938636
Pubmed	The bifunctional iron-responsive element binding protein/cytosolic aconitase: the role of active-site residues in ligand binding and regulation.	IREB2 ACO1	9.28e-07	2	34	2	8041788
Pubmed	Diurnal control of iron responsive element containing mRNAs through iron regulatory proteins IRP1 and IRP2 is mediated by feeding rhythms.	IREB2 ACO1	9.28e-07	2	34	2	38773499
Pubmed	Iron regulatory protein (IRP)-mediated iron homeostasis is critical for neutrophil development and differentiation in the bone marrow.	IREB2 ACO1	2.78e-06	3	34	2	36197975
Pubmed	Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum.	IREB2 ACO1	2.78e-06	3	34	2	18177727
Pubmed	Posttranslational stability of the heme biosynthetic enzyme ferrochelatase is dependent on iron availability and intact iron-sulfur cluster assembly machinery.	IREB2 ACO1	2.78e-06	3	34	2	19965627
Pubmed	IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2α mRNA translation.	IREB2 ACO1	2.78e-06	3	34	2	23777768
Pubmed	Iron regulatory protein-1 and -2: transcriptome-wide definition of binding mRNAs and shaping of the cellular proteome by iron regulatory proteins.	IREB2 ACO1	2.78e-06	3	34	2	21940823
Pubmed	Claudins 6, 9, and 13 are developmentally expressed renal tight junction proteins.	CLDN4 CLDN6	2.78e-06	3	34	2	16774906
Pubmed	The IRP1-HIF-2α axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption.	IREB2 ACO1	2.78e-06	3	34	2	23395174
Pubmed	Iron insufficiency compromises motor neurons and their mitochondrial function in Irp2-null mice.	IREB2 ACO1	2.78e-06	3	34	2	22003390
Pubmed	Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice.	IREB2 SCO2	2.78e-06	3	34	2	26752519
Pubmed	F-box and leucine-rich repeat protein 5 (FBXL5) is required for maintenance of cellular and systemic iron homeostasis.	IREB2 ACO1	2.78e-06	3	34	2	23135277
Pubmed	Iron homeostasis during transfusional iron overload in beta-thalassemia and sickle cell disease: changes in iron regulatory protein, hepcidin, and ferritin expression.	IREB2 ACO1	2.78e-06	3	34	2	17613866
Pubmed	Iron Regulatory Proteins Mediate Host Resistance to Salmonella Infection.	IREB2 ACO1	2.78e-06	3	34	2	26190773
Pubmed	Iron regulatory protein 1 sustains mitochondrial iron loading and function in frataxin deficiency.	IREB2 ACO1	5.56e-06	4	34	2	25651183
Pubmed	Essential role of systemic iron mobilization and redistribution for adaptive thermogenesis through HIF2-α/hepcidin axis.	IREB2 ACO1	5.56e-06	4	34	2	34593646
Pubmed	TLR2 activation induced by H. pylori LPS promotes the differential expression of claudin-4, -6, -7 and -9 via either STAT3 and ERK1/2 in AGS cells.	CLDN4 CLDN6	5.56e-06	4	34	2	29031421
Pubmed	Immunolocalization and regulation of iron handling proteins ferritin and ferroportin in the retina.	IREB2 ACO1	5.56e-06	4	34	2	15354085
Pubmed	Efficient generation and mapping of recessive developmental mutations using ENU mutagenesis.	RYR1 PKD1	9.26e-06	5	34	2	11818962
Pubmed	Control of iron homeostasis by an iron-regulated ubiquitin ligase.	IREB2 ACO1	9.26e-06	5	34	2	19762596
Pubmed	HERC2 targets the iron regulator FBXL5 for degradation and modulates iron metabolism.	IREB2 ACO1	1.39e-05	6	34	2	24778179
Pubmed	An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis.	IREB2 ACO1	1.39e-05	6	34	2	19762597
Pubmed	An Oxygen-Dependent Interaction between FBXL5 and the CIA-Targeting Complex Regulates Iron Homeostasis.	IREB2 ACO1	1.94e-05	7	34	2	31229404
Pubmed	A study of genes that may modulate the expression of hereditary hemochromatosis: transferrin receptor-1, ferroportin, ceruloplasmin, ferritin light and heavy chains, iron regulatory proteins (IRP)-1 and -2, and hepcidin.	IREB2 ACO1	2.59e-05	8	34	2	11783942
Pubmed	Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands.	CLDN4 CLDN6	2.59e-05	8	34	2	9892664
Pubmed	Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.	IREB2 ARMC10 FASN HTRA2 SLC25A28 ACO1 LACTB	2.66e-05	926	34	7	20877624
Pubmed	Claudin association with CD81 defines hepatitis C virus entry.	CLDN4 CLDN6	4.15e-05	10	34	2	20375010
Pubmed	claudin-18, a novel downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor, encodes lung- and stomach-specific isoforms through alternative splicing.	CLDN4 CLDN6	4.15e-05	10	34	2	11585919
Pubmed	Permeability barrier dysfunction in transgenic mice overexpressing claudin 6.	CLDN4 CLDN6	4.15e-05	10	34	2	11923212
Pubmed	The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2.	ARMC10 ARMCX4	5.07e-05	11	34	2	22569362
Pubmed	Orphan nuclear receptor Nurr1 is essential for Ret expression in midbrain dopamine neurons and in the brain stem.	PHOX2A ACHE	5.07e-05	11	34	2	11749040
Pubmed	Expression of claudins in murine tooth development.	CLDN4 CLDN6	5.07e-05	11	34	2	17075866
Pubmed	A mitochondrial protein compendium elucidates complex I disease biology.	IREB2 ARMC10 FASN HTRA2 SLC25A28 ACO1 LACTB	5.80e-05	1047	34	7	18614015
Pubmed	Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins.	CLDN4 CLDN6	6.08e-05	12	34	2	10601346
Pubmed	CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family.	CLDN4 CLDN6	6.08e-05	12	34	2	12736707
Pubmed	Expression patterns of claudin family of tight junction membrane proteins in developing mouse submandibular gland.	CLDN4 CLDN6	8.38e-05	14	34	2	15366020
Pubmed	The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo.	IREB2 ACO1	1.10e-04	16	34	2	21907140
Pubmed	Spinal neural tube closure depends on regulation of surface ectoderm identity and biomechanics by Grhl2.	CLDN4 CLDN6	1.25e-04	17	34	2	31171776
Pubmed	Analysis of mice carrying targeted mutations of the glucocorticoid receptor gene argues against an essential role of glucocorticoid signalling for generating adrenal chromaffin cells.	PHOX2A ACHE	1.25e-04	17	34	2	10357937
Pubmed	Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development.	IREB2 ACO1	1.57e-04	19	34	2	16787915
Pubmed	Biology of claudins.	CLDN4 CLDN6	1.57e-04	19	34	2	18480174
Pubmed	Tight junction proteins.	CLDN4 CLDN6	1.93e-04	21	34	2	12475568
Pubmed	Multifunctional strands in tight junctions.	CLDN4 CLDN6	1.93e-04	21	34	2	11283726
Pubmed	Claudin-based barrier in simple and stratified cellular sheets.	CLDN4 CLDN6	1.93e-04	21	34	2	12231346
Pubmed	Tight junctions of the blood-brain barrier.	CLDN4 CLDN6	1.93e-04	21	34	2	10690502
Pubmed	The roles of claudin superfamily proteins in paracellular transport.	CLDN4 CLDN6	1.93e-04	21	34	2	11247307
Pubmed	E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions.	CLDN4 DSC2	1.93e-04	21	34	2	15775979
Pubmed	Identification of proteins that interact with alpha A-crystallin using a human proteome microarray.	FASN ARMCX4 SLC25A28	2.11e-04	118	34	3	24453475
Pubmed	Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC).	FASN SLC2A8	2.12e-04	22	34	2	20965718
Pubmed	Structure and function of claudins.	CLDN4 CLDN6	2.32e-04	23	34	2	18036336
Pubmed	The claudins.	CLDN4 CLDN6	2.32e-04	23	34	2	19706201
Pubmed	FBXL5 Inactivation in Mouse Brain Induces Aberrant Proliferation of Neural Stem Progenitor Cells.	IREB2 ACO1	2.74e-04	25	34	2	28069738
Pubmed	Dynamic distribution of claudin proteins in pancreatic epithelia undergoing morphogenesis or neoplastic transformation.	CLDN4 CLDN6	2.97e-04	26	34	2	22275141
Pubmed	Role of the E3 ubiquitin ligase RNF157 as a novel downstream effector linking PI3K and MAPK signaling pathways to the cell cycle.	HSD17B12 TXNDC5	3.45e-04	28	34	2	28655764
Pubmed	Biosynthesis of triacylglycerols.	HSD17B12 FASN	3.45e-04	28	34	2	8944226
Pubmed	Glycogen Dynamics Drives Lipid Droplet Biogenesis during Brown Adipocyte Differentiation.	FASN STBD1	3.97e-04	30	34	2	31693883
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	FASN FCGBP DSC2 ACO1 RYR1 PKD1	4.09e-04	1016	34	6	19056867
Pubmed	A new intracellular targeting motif in the cytoplasmic tail of the spike protein may act as a target to inhibit SARS-CoV-2 assembly.	SCO2 HTRA2	5.10e-04	34	34	2	36572190
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	HSD17B12 ARMC10 SCO2 STBD1 ARMCX4 HTRA2 LACTB	5.20e-04	1496	34	7	32877691
Pubmed	Global Proximity Interactome of the Human Macroautophagy Pathway.	NCOA7 STBD1	5.41e-04	35	34	2	34524948
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	HSD17B12 FASN STBD1 ANKRD50 DSC2	5.88e-04	708	34	5	39231216
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FASN CLDN4 RYR1 PLEKHH3 ARHGEF10L PKD1	6.37e-04	1105	34	6	35748872
Pubmed	Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function.	ARMC10 SCO2 HTRA2 LACTB	6.86e-04	413	34	4	27499296
Pubmed	Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.	ARMC10 SCO2 HTRA2 SLC25A28 C19orf12 LACTB	7.36e-04	1136	34	6	34800366
Pubmed	Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.	FCGBP DSC2	7.43e-04	41	34	2	16740002
Pubmed	14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking.	FASN TXNDC5 ACO1	7.97e-04	186	34	3	14744259
Pubmed	Claudin-9 constitutes tight junctions of folliculo-stellate cells in the anterior pituitary gland.	CLDN4 CLDN6	8.17e-04	43	34	2	34737342
Pubmed	Network organization of the human autophagy system.	HSD17B12 NCOA7 STBD1 HTRA2	8.46e-04	437	34	4	20562859
Cytoband	19q13.1	FCGBP RYR1	7.71e-04	55	34	2	19q13.1
GeneFamily	Claudins	CLDN4 CLDN6	4.20e-04	23	24	2	488
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	ARMC10 ARMCX4	1.48e-03	43	24	2	409
GeneFamily	Short chain dehydrogenase/reductase superfamily	HSD17B12 FASN	4.53e-03	76	24	2	743
Coexpression	HOWARD_NEUTROPHIL_INACT_MONOV_INFLUENZA_A_INDONESIA_05_2005_H5N1_AGE_18_49YO_1DY_UP	NCOA7 SCO2 SLC25A28 ACO1 C19orf12 LACTB	1.05e-05	394	34	6	M40996
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-SMG_basal_1\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	NCOA7 CLDN4 FCGBP DSC2	9.15e-06	174	34	4	aceca0a22bb1e380835e792681cfc9b752fb5496
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NCOA7 CLDN4 FCGBP TXNDC5	1.22e-05	187	34	4	71d99a1a95d3692a2891da49d4a243bae6e07fd0
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NCOA7 FASN STBD1 ACHE	1.27e-05	189	34	4	da014519d6eb21bc2dc2ed65eafe638b42a068ed
ToppCell	18-Airway-Epithelial-Submucosal_gland\|Airway / Age, Tissue, Lineage and Cell class	NCOA7 CLDN4 FCGBP DSC2	1.27e-05	189	34	4	c1ea2dc44cf5340378e56e0ffc2e6f64e6c95a58
ToppCell	moderate-Epithelial-IRC-IFNG_responsive_cell\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	NCOA7 CLDN4 FCGBP ACHE	1.43e-05	195	34	4	4ea79451b9c040650a74831b64a41d36b180ac0f
ToppCell	NS-moderate-d_16-33-Epithelial-IRC-IFNG_responsive_cell\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	NCOA7 CLDN4 FCGBP ACHE	1.49e-05	197	34	4	8eda7d5a44b18c805c963235aea794e9223d1ac0
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CLDN4 FCGBP ACHE	1.58e-04	138	34	3	2e46d546ad962aa0fde5b1c18c2a5370a4424e9f
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Degenerative_Ascending_Thin_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CLDN4 FCGBP ACHE	1.79e-04	144	34	3	163c591fedad2beb7f92531e6240e9554f90ea40
ToppCell	Striatum-Macroglia-POLYDENDROCYTE-P1\|Striatum / BrainAtlas - Mouse McCarroll V32	HSD17B12 FCGBP SLC34A3	1.79e-04	144	34	3	9d6133558728fa148050eb4f0be33756d71310b0
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PHOX2A STBD1 ACHE	1.79e-04	144	34	3	121853910eeea1ea0642b3cc99f9200015480368
ToppCell	Bronchial_Biopsy-Epithelial-Goblet_1\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	C20orf203 PTPRH CLDN6	1.82e-04	145	34	3	e932361734839c14ffa0c1e028dcef9c833f884f
ToppCell	Bronchial_Biopsy-Epithelial-Goblet_1\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	C20orf203 PTPRH CLDN6	1.86e-04	146	34	3	a4f2e3ea79e7154873c01739672ec6454547e6a6
ToppCell	droplet-Lung-nan-3m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HTRA2 RYR1 ARHGEF10L	2.14e-04	153	34	3	f6ef14d949107c08cb3690e26ec91e194cb43518
ToppCell	droplet-Lung-nan-3m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HTRA2 RYR1 ARHGEF10L	2.14e-04	153	34	3	6dcab3d50ab50051955204dc4e4a64c1ca855bcd
ToppCell	Control-Endothelial-Epi-like-Alv_Cap\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NCOA7 STBD1 ACO1	2.30e-04	157	34	3	2c369660c752c0fb3bd798a561d3359e2f9aa983
ToppCell	Control-Endothelial-Epi-like\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NCOA7 STBD1 ACO1	2.30e-04	157	34	3	4d02c50d5d1b892ea241e98724386d8a5a156a46
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NCOA7 CLDN4 ACHE	2.48e-04	161	34	3	0d863d7d369391dd6148e1de6d6f8033dcb8fe0f
ToppCell	3'-GW_trimst-1-SmallIntestine-Epithelial-epithelial_progenitor_cell-Distal_progenitor\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CLDN4 DSC2 CLDN6	2.62e-04	164	34	3	ea02ca343b2b28e437304de889e2ae1e315a1197
ToppCell	LV-11._Adipocyte\|World / Chamber and Cluster_Paper	FASN ACO1 C19orf12	2.71e-04	166	34	3	7e5852891714465c6228c9f955fd511ec79d0e02
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NCOA7 CLDN4 FCGBP	2.71e-04	166	34	3	9e98e6070055bfc780becee52d77830e06b6d854
ToppCell	droplet-Lung-18m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HTRA2 RYR1 ARHGEF10L	2.81e-04	168	34	3	4b5be7c6662eceddf90a65015f12908278d1664e
ToppCell	droplet-Lung-18m-Hematologic-myeloid-non-classical_monocyte\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HTRA2 RYR1 ARHGEF10L	2.81e-04	168	34	3	689c41f6e9f65381570991cc311cba49a57ec955
ToppCell	droplet-Lung-LUNG-30m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HTRA2 RYR1 ARHGEF10L	2.86e-04	169	34	3	411556e93adcbb7e4d79b02f3dc72963ec8a0759
ToppCell	droplet-Lung-nan-18m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HTRA2 RYR1 ARHGEF10L	2.86e-04	169	34	3	c96e0f3241d13926dbee9f91c0c8c5bfa7479a0d
ToppCell	droplet-Lung-LUNG-30m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HTRA2 RYR1 ARHGEF10L	2.86e-04	169	34	3	39b1acfd099abb9de18c29c05c7a67709ea76775
ToppCell	droplet-Lung-21m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HTRA2 RYR1 ARHGEF10L	2.86e-04	169	34	3	b059304543876f514d5c7214f1f0a2da00f10a67
ToppCell	droplet-Lung-21m-Hematologic-myeloid-non-classical_monocyte\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HTRA2 RYR1 ARHGEF10L	2.86e-04	169	34	3	945f737984c4de70a4e9c214053b005358053dd5
ToppCell	droplet-Lung-nan-18m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HTRA2 RYR1 ARHGEF10L	2.86e-04	169	34	3	ba023ee7bb165c2bfbefc2d969ff32ca1eeed33b
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Epithelial-goblet\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CLDN4 FCGBP DSC2	2.91e-04	170	34	3	9bea81031cdfe45e8cddac3a3afd9ca6c331c45a
ToppCell	droplet-Liver-LIVER_NPC-30m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLDN4 FCGBP PTPRH	2.91e-04	170	34	3	a121e10099faaeb60251eec162f38caf7c4238c2
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CLDN4 FCGBP ARHGEF10L	2.91e-04	170	34	3	5d5f208682be21ed58320f5fc083a7898f8712da
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Epithelial-goblet-Goblet_cell\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CLDN4 FCGBP DSC2	2.91e-04	170	34	3	2c5a1469e5743870e96e6c2cc92f0c5096b79f51
ToppCell	ileum\|World / shred on tissue and cell subclass	CLDN4 DSC2 PTPRH	2.91e-04	170	34	3	9f1211bd4287620e19a59f21e6ecdca3e42e0260
ToppCell	TCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-6\|TCGA-Bladder / Sample_Type by Project: Shred V9	SCO2 DSC2 TM4SF19	2.96e-04	171	34	3	0e78389f8f3d54570a6deb3dd307b865b46307e9
ToppCell	droplet-Lung-1m-Hematologic-myeloid-non-classical_monocyte\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HTRA2 RYR1 ARHGEF10L	2.96e-04	171	34	3	00739085fdbc4d64c9faacba2c2adeab580dd2b1
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CLDN4 FCGBP ARMCX4	3.01e-04	172	34	3	5401ac7739f95fb8681cfb4747ab6e447a3c2ae8
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CLDN4 FCGBP ARMCX4	3.01e-04	172	34	3	b3da7f488d191214d7bb74fbac189fe8c29ee6cd
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NCOA7 CLDN4 FCGBP	3.01e-04	172	34	3	63a91974b12c3f7f0c6bf66c30088d7fc07f5cea
ToppCell	droplet-Lung-nan-21m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HTRA2 RYR1 ARHGEF10L	3.01e-04	172	34	3	51bea97564a33f0060c546c9be4bf8bf8f1660f6
ToppCell	droplet-Lung-1m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HTRA2 RYR1 ARHGEF10L	3.01e-04	172	34	3	5f58ff6cac32546d07b2a49ed250b6c7aa417188
ToppCell	droplet-Lung-nan-21m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HTRA2 RYR1 ARHGEF10L	3.01e-04	172	34	3	be4dd4ba8d7a651677c797c25fd75f14e627415a
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CLDN4 FCGBP ARMCX4	3.01e-04	172	34	3	74dd4a7acb2cf857fed20219e4d7dc1adfbaa398
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCOA7 DSC2 PTPRH	3.06e-04	173	34	3	e1378201b15ffb98e196ac39fe3ee4b4078953bd
ToppCell	facs-Large_Intestine-Proximal-3m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCOA7 DSC2 PTPRH	3.06e-04	173	34	3	99532bb768ee35fed939a377acb5215d3f8904bd
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NCOA7 CLDN4 SPRED3	3.11e-04	174	34	3	207aa0118633cbe9a65839bbb1bb3ba9f8118ad2
ToppCell	droplet-Liver-HEPATOCYTES-1m-Epithelial-Hepatocyte_(Periportal)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FASN STBD1 DSC2	3.17e-04	175	34	3	5c38d4b6c03473d841e6203a7efaa6dcb2d59386
ToppCell	droplet-Liver-LIVER_NPC-30m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLDN4 FCGBP PTPRH	3.17e-04	175	34	3	f7cd2ef79d91d64976fcdb5f1e7343b24ba27456
ToppCell	droplet-Kidney-nan-18m-Epithelial-collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLDN4 ARMCX4 SPRED3	3.22e-04	176	34	3	533d544852038c0612aacf87f4b1c88ff7aace82
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.4.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ARMC10 DSC2 ACO1	3.44e-04	180	34	3	fb8bc639f7f94e7aed9f9d708d5d5c78178533ae
ToppCell	RA-11._Adipocyte\|RA / Chamber and Cluster_Paper	HSD17B12 FASN ACO1	3.44e-04	180	34	3	d48a3d27357f7d184132a6805950f93080146b59
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Epithelial-epithelial_progenitor_cell-Proximal_progenitor\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CLDN4 DSC2 CLDN6	3.44e-04	180	34	3	8d9be9cfdf98e5888654a28ab12e5e89f201af00
ToppCell	15-Airway-Epithelial-Submucosal_gland\|Airway / Age, Tissue, Lineage and Cell class	CLDN4 FCGBP DSC2	3.44e-04	180	34	3	283bb0d58811947bfda4e286b9ec87d869c8e29e
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLDN4 ACHE CLDN6	3.50e-04	181	34	3	7af469f5bcb9b1ab3f35b2758bf2afb87e8eba57
ToppCell	droplet-Heart-4Chambers-21m-Neuronal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLDN4 FCGBP CLDN6	3.50e-04	181	34	3	3fd16229a63de0971db5d48860c01173d7db518f
ToppCell	wk_08-11-Epithelial-Proximal_epithelial-Proximal_secretory_1\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	NCOA7 CLDN4 FCGBP	3.50e-04	181	34	3	bab282cb0d9fc049f6fb094cf8b1fba104f4ea17
ToppCell	facs-Marrow-T-cells-3m-Hematologic-Unknown_Progenitor\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TXNDC5 RYR1 PLEKHH3	3.61e-04	183	34	3	b0b835f3b1de1bd46a47e1b805aa8994cd3a4e3e
ToppCell	droplet-Heart-4Chambers-21m-Neuronal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLDN4 FCGBP CLDN6	3.61e-04	183	34	3	a046b569bc10083d471b420eb2c6fee93437602d
ToppCell	droplet-Heart-4Chambers-21m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLDN4 FCGBP CLDN6	3.61e-04	183	34	3	4de2082dca2569d3aac3c9b466f27971c82d302b
ToppCell	E12.5-Epithelial-airway_epithelial_cell-club_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ARMC10 CLDN4 CLDN6	3.67e-04	184	34	3	a69c3c57cd939b2888f548a0fbca3392ad310445
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.3.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DSC2 ACO1 LACTB	3.67e-04	184	34	3	840fac463665ed18752f402f7d1ef2e5052bdf74
ToppCell	E12.5-Epithelial-airway_epithelial_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ARMC10 CLDN4 CLDN6	3.67e-04	184	34	3	3df78b17098b50e1a7f2c8791bf2d0806328330a
ToppCell	Control-Epithelial_cells-Airway_goblet\|Control / group, cell type (main and fine annotations)	CLDN4 FCGBP PTPRH	3.67e-04	184	34	3	d92a71441e4e19f8c301999d8186f8e48e3cd162
ToppCell	facs-Heart-LV-24m-Myeloid-macrophage\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLDN4 FCGBP CLDN6	3.73e-04	185	34	3	a835f821a5e6568d648df831ec4c2d0048d67093
ToppCell	facs-Heart-LV-24m-Myeloid-macrophage\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLDN4 FCGBP CLDN6	3.73e-04	185	34	3	386b08bcb304db543e3c5ff75f85e99bf0c592df
ToppCell	3'-Broncho-tracheal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_acinar_cell-SMG_duct-SMG_duct_L.0.6.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NCOA7 CLDN4 FCGBP	3.73e-04	185	34	3	c4ca213a59ffab183a7719c2b4bc3f658a95002d
ToppCell	droplet-Fat-Scat-21m-Epithelial-epithelial_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLDN4 FCGBP DSC2	3.79e-04	186	34	3	de88fafac51049ec1920695844d8ce8057940272
ToppCell	droplet-Fat-Scat-21m-Epithelial\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLDN4 FCGBP DSC2	3.79e-04	186	34	3	59710cff3f6f7c318ee2524b44c1a909f312c25e
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial-large_intestine_goblet_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLDN4 FCGBP TXNDC5	3.79e-04	186	34	3	32d30f08b20a0a28e38b37bd52ab26d1d43736ce
ToppCell	droplet-Fat-Scat-21m-Epithelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLDN4 FCGBP DSC2	3.79e-04	186	34	3	7ff73ab8fed5da779ee9c7bd2e14a8363edb7509
ToppCell	E12.5-Epithelial-epithelial_progenitor_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PHOX2A CLDN4 CLDN6	3.85e-04	187	34	3	ab6f4d387218b4651fdadbf269806c1ddc96a1d2
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	WHAMM ARMCX4 SLC2A8	3.85e-04	187	34	3	3699d5e71d779da922920aa3160895db187bf81b
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	WHAMM ARMCX4 SLC2A8	3.85e-04	187	34	3	033ba52c0c2f9978784947098fa697368ae44834
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CLDN4 FCGBP ARHGEF10L	3.85e-04	187	34	3	c41a2c81dd2ceef303f39f699032aa7d6ea67cf0
ToppCell	PCW_13-14-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	CLDN4 FCGBP CLDN6	3.91e-04	188	34	3	0d86044bc340e3efb90d0022dd299873639d831c
ToppCell	RA-11._Adipocyte\|World / Chamber and Cluster_Paper	HSD17B12 FASN ACO1	3.91e-04	188	34	3	4dac9d636e5cad4cda540b93d4bfed6b5732c880
ToppCell	facs-Trachea-24m-Epithelial-airway_epithelial-respiratory_basal_cell-basal_epithelial_cell_of_trachea\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CLDN4 FCGBP DSC2	3.97e-04	189	34	3	ee15b4fb3a1cfda80bcf210a23f04f242594015e
ToppCell	facs-Trachea-24m-Epithelial-airway_epithelial-respiratory_basal_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CLDN4 FCGBP DSC2	3.97e-04	189	34	3	dc6f6fae84347d145bea71b49eaeeb3028e9c4ae
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CLDN4 FCGBP ARHGEF10L	4.03e-04	190	34	3	1cf023e3c6924d6a06f353d4b62444b6f2fee8a7
ToppCell	droplet-Kidney-nan-18m-Epithelial-kidney_collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLDN4 ARMCX4 DSC2	4.03e-04	190	34	3	c408d4033a130c0168159a5b6f286fd2b2a9a39d
ToppCell	facs-Tongue-nan-3m-Epithelial-suprabasal\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLDN4 DSC2 ARHGEF10L	4.03e-04	190	34	3	719a5cecc3e8001ca9c38165258b5ff9c800713a
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1-AT1_L.0.5.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NCOA7 CLDN4 ACHE	4.03e-04	190	34	3	8ceb327dc995f4b83b05d5d6630e1294f0cb49bd
ToppCell	wk_08-11-Epithelial-Airway_epithelial_progenitor-epi-stalk_early\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	FASN CLDN4 CLDN6	4.03e-04	190	34	3	9f5f65869dad9a43ac94f81f9a19c72ffe5adc3c
ToppCell	droplet-Marrow-nan-24m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TXNDC5 LACTB ARHGEF10L	4.03e-04	190	34	3	e2fdbfaf08da3274b6bdda615386aa880040a90a
ToppCell	droplet-Kidney-nan-18m-Epithelial-Epcam____kidney_collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLDN4 ARMCX4 DSC2	4.03e-04	190	34	3	d4910c37045a8b8bb53b37625263bc0a47b6e3f8
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CLDN4 FCGBP ARHGEF10L	4.03e-04	190	34	3	59bbbd2c8d4b7ce46c54ca8022b1557e7e5eee2a
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-epithelial_cell_of_lung-Transitional_Club-AT2-Transitional_Club-AT2_L.0.4.1.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NCOA7 FASN CLDN4	4.09e-04	191	34	3	1c46f4eabc1fd790069d5d8b29580d3904e2ef41
ToppCell	cellseq-Epithelial-Epithelial_Glandular-SMG_Basal/Duct\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NCOA7 CLDN4 FCGBP	4.09e-04	191	34	3	30e7cc5f7eadf90ab0900a73fdfe48f9a1adcbfb
ToppCell	cellseq-Epithelial-Epithelial_Glandular-SMG_Basal/Duct-SMG_Basal/Duct\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NCOA7 CLDN4 FCGBP	4.09e-04	191	34	3	41d2f5278f6d5f52a5bdf4f3df70969481c00162
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NCOA7 CLDN4 FCGBP	4.09e-04	191	34	3	529068029fb461df766135576dd0d8b5980f9bc0
ToppCell	3'-Broncho-tracheal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_acinar_cell-SMG_duct\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NCOA7 CLDN4 FCGBP	4.15e-04	192	34	3	c227ab1914191e839fc39c9adc2080026d4b04fc
ToppCell	Severe-Myeloid-Macrophages-FABP4+\|Severe / Condition, Lineage, Cell class and cell subclass	ACO1 TM4SF19 RYR1	4.15e-04	192	34	3	30aad927ad40d8abaf9d0539bf8cb9d88d16f24d
ToppCell	3'-Broncho-tracheal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_acinar_cell-SMG_duct-SMG_duct_L.0.6.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NCOA7 CLDN4 FCGBP	4.15e-04	192	34	3	bf187a57a559ab732bb815892af45ca922966ac6
ToppCell	3'-Broncho-tracheal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_acinar_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NCOA7 CLDN4 FCGBP	4.15e-04	192	34	3	f573b2d205bd4d053a548af3fe3ff9de7be0cd2b
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-goblet\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CLDN4 FCGBP ARHGEF10L	4.22e-04	193	34	3	402aad2f9e789ad1f2e1536cdc9ce61de7625427
ToppCell	droplet-Kidney-nan-3m-Epithelial-Epcam____kidney_collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLDN4 ARMCX4 DSC2	4.22e-04	193	34	3	536b277d90070c4571c592a3c6323b4bf4819f67
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-Epcam____kidney_collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLDN4 DSC2 ACHE	4.22e-04	193	34	3	0208fcd8ea4662f40fc2c072ac220d97823eec12
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-kidney_collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLDN4 DSC2 ACHE	4.22e-04	193	34	3	04d47ba7cc1f19f1ffb18d9e68469e75063697cf
ToppCell	droplet-Kidney-nan-3m-Epithelial-kidney_collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLDN4 ARMCX4 DSC2	4.22e-04	193	34	3	0499611c21d283321ef6dd24add154dea48da1b7
ToppCell	facs-Tongue-nan-3m-Epithelial-keratinocyte\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLDN4 DSC2 ARHGEF10L	4.22e-04	193	34	3	33437fdb417d78463caee14a9f0e094da1733829
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-goblet-Goblet_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CLDN4 FCGBP ARHGEF10L	4.22e-04	193	34	3	7ee3b1ef5c455f321b4e154ae62c69543fe9b30e
Drug	pyrazinoic acid	IREB2 FASN ACO1	7.86e-07	13	33	3	CID000001047
Drug	p-nitrophenylhydroxylamine	IREB2 ACO1	2.04e-06	2	33	2	CID005486551
Drug	ferroheme-O	IREB2 SCO2 RYR1	2.65e-06	19	33	3	CID004369157
Drug	yersiniabactin	IREB2 SCO2 ACO1	1.21e-05	31	33	3	CID005462519
Drug	Cicloral	IREB2 ACO1	1.22e-05	4	33	2	CID000012628
Drug	BFNU	IREB2 ACO1	1.22e-05	4	33	2	CID000096886
Drug	2-hydroxyisonicotinate	IREB2 ACO1	1.22e-05	4	33	2	CID000280756
Drug	croconic acid	IREB2 ACO1	2.03e-05	5	33	2	CID000546874
Drug	AC1NSY0C	IREB2 ACO1	2.03e-05	5	33	2	CID005372273
Drug	1,3-difluoroacetone	IREB2 ACO1	2.03e-05	5	33	2	CID000228397
Drug	p-nitroacetanilide	IREB2 ACO1	2.03e-05	5	33	2	CID000007691
Drug	1,3-difluoro-2-propanol	IREB2 ACO1	2.03e-05	5	33	2	CID000067985
Drug	fluoroacetaldehyde	IREB2 ACO1	2.03e-05	5	33	2	CID000073766
Drug	gliftor	IREB2 ACO1	2.03e-05	5	33	2	CID000197109
Drug	cinchoninic acid	IREB2 ACO1	2.03e-05	5	33	2	CID000010243
Drug	manganese pyrophosphate	IREB2 ACO1	3.04e-05	6	33	2	CID000152037
Drug	oxalomalic acid	IREB2 ACO1	3.04e-05	6	33	2	CID000439620
Drug	FE-S CLUSTER	IREB2 ACO1	3.04e-05	6	33	2	CID006416167
Drug	mono-(2-ethylhexyl)phthalate	NCOA7 FASN FCGBP DSC2 PTPRH CLDN6 RYR1	3.62e-05	658	33	7	ctd:C016599
Drug	Fc nu	IREB2 ACO1	4.26e-05	7	33	2	CID000083807
Drug	3-methylitaconate	IREB2 ACO1	5.67e-05	8	33	2	CID006438940
Drug	C04226	IREB2 ACO1	5.67e-05	8	33	2	CID000151255
Drug	citrazinic acid	IREB2 ACO1	5.67e-05	8	33	2	CID000007425
Drug	propyl gallate	HSD17B12 IREB2 ACO1	6.91e-05	55	33	3	CID000004947
Drug	Mn(III)TMPyP	IREB2 ACO1	7.29e-05	9	33	2	CID005486195
Drug	NSC-254681	IREB2 ACO1	7.29e-05	9	33	2	CID005458489
Drug	pyrenebutyl methylphosphonofluoridate	FASN ACHE	7.29e-05	9	33	2	CID000125653
Drug	Ferrosanol	IREB2 ACO1	7.29e-05	9	33	2	CID000028366
Drug	2-hydroxypalmitic acid	IREB2 ACO1	7.29e-05	9	33	2	CID000092836
Drug	heme a3	IREB2 SCO2 RYR1	8.53e-05	59	33	3	CID005489981
Drug	3,5,5-trimethylhexanoyl)ferrocene	IREB2 ACO1	9.10e-05	10	33	2	CID000071539
Drug	AC1NA019	SCO2 RYR1	9.10e-05	10	33	2	CID004369409
Drug	arginine hydroxamate	IREB2 ACO1	9.10e-05	10	33	2	CID000151275
Drug	AC1L4YZD	SCO2 RYR1	9.10e-05	10	33	2	CID000166928
Drug	gabapentin	IREB2 ACO1 RYR1 PKD1	1.01e-04	169	33	4	CID000003446
Drug	lercanidipine	HSD17B12 RYR1 PKD1	1.04e-04	63	33	3	CID000065866
Drug	2-methylaconitate	IREB2 ACO1	1.11e-04	11	33	2	CID000000345
Drug	1,4-dinitrobenzene	IREB2 ACO1	1.11e-04	11	33	2	CID000007492
Drug	NSC299933	ACHE RYR1	1.57e-04	13	33	2	CID000431902
Drug	C015407	IREB2 ACO1	1.57e-04	13	33	2	CID003014226
Drug	Benfluorex hydrochloride [23642-66-2]; Down 200; 10.4uM; MCF7; HT_HG-U133A	FASN CLDN4 HTRA2 SLC25A28	1.76e-04	195	33	4	5327_DN
Drug	glufosinate	IREB2 ACO1 RYR1	1.81e-04	76	33	3	CID000004794
Drug	alpha-methylisocitrate	IREB2 ACO1	1.83e-04	14	33	2	CID000000513
Drug	beta-isopropyl-tropolone	IREB2 ACO1	1.83e-04	14	33	2	CID000080297
Drug	paraquat	IREB2 HTRA2 ACHE ACO1	1.90e-04	199	33	4	CID000015938
Drug	bacillibactin	IREB2 ACO1	2.41e-04	16	33	2	CID000125349
Drug	CoA-oxalate	HSD17B12 FASN	2.41e-04	16	33	2	CID000000973
Drug	Gal 1	HSD17B12 IREB2 ACO1	2.71e-04	87	33	3	CID000173707
Drug	betulin	IREB2 ACO1	2.73e-04	17	33	2	CID000072326
Drug	tempol	HSD17B12 IREB2 SCO2 ACO1	2.83e-04	221	33	4	CID000137994
Drug	3-[18-(2-carboxyethyl)-8-(1-hydroxy-5,9,13-trimethyl-tetradeca-4,8,12-trienyl)-3,7,12,17-tetramethyl-13-vinyl-1,2,3,6,7,8,9,12,17,18-decahydroporphine-21,22,23,24-tetraid-2-yl]propionic acid;iron(4+)	SCO2 RYR1	3.07e-04	18	33	2	CID011984599
Drug	AC1O7EMV	IREB2 ACO1	3.07e-04	18	33	2	CID005460650
Drug	AC1L1EVQ	IREB2 ACO1	3.43e-04	19	33	2	CID000002970
Drug	AC1L1G3W	HSD17B12 IREB2 ACO1 RYR1	3.69e-04	237	33	4	CID000003514
Drug	6-nitrotryptophan	IREB2 ACO1	3.81e-04	20	33	2	CID000600156
Drug	muramic acids	IREB2 ACO1	3.81e-04	20	33	2	CID000092864
Drug	isradipine	HTRA2 RYR1 PKD1	4.08e-04	100	33	3	CID000003784
Drug	yellow prussiate	IREB2 ACO1	4.20e-04	21	33	2	CID000161067
Drug	nonactin	IREB2 ACO1	4.62e-04	22	33	2	CID000072519
Drug	NADP	HSD17B12 FASN ACHE	4.97e-04	107	33	3	ctd:D009249
Drug	Fengycin	FASN ACO1	5.06e-04	23	33	2	CID000443591
Drug	AC1L1ICD	ACO1 RYR1	5.06e-04	23	33	2	CID000004516
Drug	doxorubicinol	IREB2 ACO1	5.06e-04	23	33	2	CID000083970
Drug	propionate	IREB2 FASN ACHE ACO1	5.39e-04	262	33	4	CID000001032
Drug	iron azide hydrate	IREB2 ACO1	5.51e-04	24	33	2	CID004475494
Drug	iron (II) d-gluconate dihydrate	IREB2 ACO1	6.48e-04	26	33	2	CID000071372
Drug	Schiff's reagent	FASN ACHE	6.48e-04	26	33	2	CID000010484
Drug	dialuric acid	IREB2 ACO1	6.48e-04	26	33	2	CID000067956
Drug	fluorocitrate	IREB2 ACO1	6.99e-04	27	33	2	CID000107647
Drug	NSC368648	IREB2 ACO1	7.52e-04	28	33	2	CID005353883
Drug	ferrous ammonium sulfate	IREB2 ACO1	7.52e-04	28	33	2	CID000024863
Drug	caged InsP3	RYR1 PKD1	8.07e-04	29	33	2	CID000122248
Drug	phenacyl bromide	IREB2 ACO1	8.07e-04	29	33	2	CID000006259
Drug	tungstopterin	IREB2 ACO1 PKD1	8.95e-04	131	33	3	CID005460240
Drug	ferric ammonium citrate	IREB2 ACO1	1.05e-03	33	33	2	CID000014457
Drug	CNS 1145	RYR1 PKD1	1.05e-03	33	33	2	CID000190902
Drug	IHC-64	RYR1 PKD1	1.05e-03	33	33	2	CID000162753
Drug	leflunomide	HSD17B12 WHAMM NCOA7 STBD1 ACO1 RYR1	1.08e-03	827	33	6	ctd:C045463
Drug	PTFE	IREB2 ACO1	1.11e-03	34	33	2	CID000008301
Drug	Ethylenethiourea	ACHE CLDN6	1.18e-03	35	33	2	ctd:D005031
Drug	atracurium	ACHE RYR1	1.18e-03	35	33	2	CID000047319
Drug	TFE-Cys	IREB2 ACO1	1.18e-03	35	33	2	CID000105059
Drug	nimodipine	ACHE RYR1 PKD1	1.20e-03	145	33	3	CID000004497
Drug	Sb-H	RYR1 PKD1	1.24e-03	36	33	2	CID005289334
Drug	cubane	IREB2 ACO1	1.31e-03	37	33	2	CID000136090
Drug	I-Su	IREB2 ACO1	1.39e-03	38	33	2	CID000449633
Drug	phosphorus anion	ACHE RYR1	1.39e-03	38	33	2	CID009548888
Drug	ICRF-187	IREB2 ACO1	1.39e-03	38	33	2	CID000030623
Drug	procaine	ACHE RYR1 PKD1	1.40e-03	153	33	3	CID000004914
Disease	porphyria (implicated_via_orthology)	IREB2 ACO1	1.07e-05	5	31	2	DOID:13268 (implicated_via_orthology)
Disease	Hypertrophic obstructive cardiomyopathy	SCO2 FASN	3.16e-04	25	31	2	C4551472
Disease	hypertrophic cardiomyopathy (implicated_via_orthology)	SCO2 PKD1	4.26e-04	29	31	2	DOID:11984 (implicated_via_orthology)
Disease	Obesity	FASN ACHE LACTB	1.29e-03	205	31	3	C0028754
Disease	Huntington's disease (is_marker_for)	TUG1 ACHE	1.42e-03	53	31	2	DOID:12858 (is_marker_for)
Disease	Hypertrophic Cardiomyopathy	SCO2 FASN	1.64e-03	57	31	2	C0007194
Disease	heart rate response to recovery post exercise	PHOX2A ACHE	1.64e-03	57	31	2	EFO_0009185
Disease	longevity	HSD17B12 PHOX2A ANKRD50	3.25e-03	284	31	3	EFO_0004300
Disease	basophil percentage of granulocytes	C20orf203 RYR1	3.45e-03	83	31	2	EFO_0007995
Disease	creatinine measurement	NCOA7 SLC34A3 STBD1 RYR1 LACTB	3.54e-03	995	31	5	EFO_0004518

Protein segments in the cluster

Peptide	Gene	Start	Entry
LLWLLGGGVGAEGRE	ACHE	21	P22303
IDGLGILGWGVGGIE	ACO1	211	P21399
LWVGGGQEGAGGQVE	ARHGEF10L	826	Q9HCE6
GLAVGGAVGGLLGAW	C19orf12	61	Q9NSK7
GKGAAWGVLLVGGPG	ANKRD50	66	Q9ULJ7
GGGGVQLGKWAILAI	DSC2	686	Q02487
SGIGSWGVAGGQVLG	ARMCX4	1606	Q5H9R4
WGVAGGQVLGGARPG	ARMCX4	1611	Q5H9R4
GAGWVAAGLLLGAGA	ARMC10	6	Q8N2F6
VNGLGILGWGVGGIE	IREB2	286	P48200
GWLGGYLAVLAGAGL	SLC34A3	371	Q8N130
LGHGWVGGLGLGLGL	LACTB	36	P83111
AGLTAHLWDLGGGAG	C20orf203	51	Q8NBC4
GWLQRGVGRGAGGGE	SLC25A28	31	Q96A46
LGAGGAVLLLLWGGG	HTRA2	111	O43464
VGGKPAGWQVGGAQG	FCGBP	3426	Q9Y6R7
VWGVGNEAGVGPGLG	HSD17B12	36	Q53GQ0
GGLGGFGLELAQWLI	FASN	1891	P49327
LLITGLFGAGLGGAW	SCO2	61	O43819
AGAGAAAGALGLLWG	RYR1	4346	P21817
AAGALGLLWGSLFGG	RYR1	4351	P21817
GLLWGSLFGGGLVEG	RYR1	4356	P21817
LALGLGLWLGALAGG	PKD1	11	P98161
GGGAGTAAAVLGGWK	PLEKHH3	621	Q7Z736
SLELGGGGGRFGLWL	NCOA7	891	Q8NI08
VTLGAAAGGVLGGWL	SLC2A8	76	Q9NY64
ELDVGGGGAWGLGLG	WHAMM	111	Q8TF30
VGWAASGLLLLGGGL	CLDN4	166	O14493
LGWAASGLLLLGGGL	CLDN6	166	P56747
GGGLAGALFVWLLRG	STBD1	11	O95210
GGWLPVGGGGLSQVS	SPRED3	16	Q2MJR0
PLKGALWAGVAGGGG	PHOX2A	226	O14813
GQEGAGGWLVVGFLL	TUG1	131	A0A6I8PU40
GRGAGALHGGAWGTV	SCART1	566	Q4G0T1
LLLLLLGHGGGGRWG	TXNDC5	21	Q8NBS9
MAGAGGGLGVWGNLV	PTPRH	1	Q9HD43
LGRHAMLGTGLWGGG	TM4SF19	51	Q96DZ7