Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cytoskeleton-nuclear membrane anchor activity	SYNE1 SYNE2	2.97e-05	5	35	2	GO:0140444
GeneOntologyBiologicalProcess	nuclear migration	NTN1 SYNE1 SYNE2	2.36e-05	34	34	3	GO:0007097
GeneOntologyBiologicalProcess	nucleus localization	NTN1 SYNE1 SYNE2	5.17e-05	44	34	3	GO:0051647
GeneOntologyCellularComponent	microtubule organizing center attachment site	SYNE1 SYNE2	1.57e-04	11	36	2	GO:0034992
GeneOntologyCellularComponent	nuclear membrane protein complex	SYNE1 SYNE2	1.57e-04	11	36	2	GO:0106083
GeneOntologyCellularComponent	nuclear membrane microtubule tethering complex	SYNE1 SYNE2	1.57e-04	11	36	2	GO:0106094
GeneOntologyCellularComponent	meiotic nuclear membrane microtubule tethering complex	SYNE1 SYNE2	1.57e-04	11	36	2	GO:0034993
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	ESYT3 EXTL1 EXTL3 LRBA MBOAT4 SYNE1 SYNE2 CYP26C1	1.58e-03	1327	36	8	GO:0042175
Domain	KASH	SYNE1 SYNE2	2.29e-05	4	37	2	PF10541
Domain	KASH	SYNE1 SYNE2	2.29e-05	4	37	2	IPR012315
Domain	KASH	SYNE1 SYNE2	2.29e-05	4	37	2	SM01249
Domain	KASH	SYNE1 SYNE2	2.29e-05	4	37	2	PS51049
Domain	Exostosin	EXTL1 EXTL3	3.80e-05	5	37	2	IPR004263
Domain	EXT_C	EXTL1 EXTL3	3.80e-05	5	37	2	IPR015338
Domain	Glyco_transf_64	EXTL1 EXTL3	3.80e-05	5	37	2	PF09258
Domain	Exostosin	EXTL1 EXTL3	3.80e-05	5	37	2	PF03016
Domain	PH-BEACH_dom	LRBA WDFY4	1.06e-04	8	37	2	IPR023362
Domain	PH_BEACH	LRBA WDFY4	1.06e-04	8	37	2	PS51783
Domain	-	LRBA WDFY4	1.06e-04	8	37	2	2.30.29.40
Domain	Beach	LRBA WDFY4	1.36e-04	9	37	2	PF02138
Domain	-	LRBA WDFY4	1.36e-04	9	37	2	1.10.1540.10
Domain	Znf_SWIM	ZSWIM6 ZSWIM5	1.36e-04	9	37	2	IPR007527
Domain	BEACH_dom	LRBA WDFY4	1.36e-04	9	37	2	IPR000409
Domain	Beach	LRBA WDFY4	1.36e-04	9	37	2	SM01026
Domain	ZF_SWIM	ZSWIM6 ZSWIM5	1.36e-04	9	37	2	PS50966
Domain	BEACH	LRBA WDFY4	1.36e-04	9	37	2	PS50197
Domain	PKD	TMEM130 PKD1L1	2.08e-04	11	37	2	PS50093
Domain	PKD_dom	TMEM130 PKD1L1	2.08e-04	11	37	2	IPR000601
Domain	-	TMEM130 PKD1L1	2.08e-04	11	37	2	2.60.40.670
Domain	-	LARGE2 EXTL1 EXTL3	5.49e-04	81	37	3	3.90.550.10
Domain	Nucleotide-diphossugar_trans	LARGE2 EXTL1 EXTL3	6.99e-04	88	37	3	IPR029044
Domain	Actinin_actin-bd_CS	SYNE1 SYNE2	9.41e-04	23	37	2	IPR001589
Domain	ACTININ_2	SYNE1 SYNE2	9.41e-04	23	37	2	PS00020
Domain	ACTININ_1	SYNE1 SYNE2	9.41e-04	23	37	2	PS00019
Domain	Spectrin	SYNE1 SYNE2	9.41e-04	23	37	2	PF00435
Domain	-	ARFGEF1 LRBA WDFY4 UNC45B	9.43e-04	222	37	4	1.25.10.10
Domain	Spectrin_repeat	SYNE1 SYNE2	1.50e-03	29	37	2	IPR002017
Domain	Spectrin/alpha-actinin	SYNE1 SYNE2	1.82e-03	32	37	2	IPR018159
Domain	SPEC	SYNE1 SYNE2	1.82e-03	32	37	2	SM00150
Domain	ARM-like	ARFGEF1 LRBA WDFY4 UNC45B	1.94e-03	270	37	4	IPR011989
Domain	ARM-type_fold	ARFGEF1 LRBA WDFY4 UNC45B	4.39e-03	339	37	4	IPR016024
Domain	CH	SYNE1 SYNE2	7.34e-03	65	37	2	SM00033
Domain	CH	SYNE1 SYNE2	8.47e-03	70	37	2	PF00307
Domain	IQ	IQCF5 IQCF1	8.71e-03	71	37	2	PF00612
Domain	-	SYNE1 SYNE2	8.71e-03	71	37	2	1.10.418.10
Domain	CH	SYNE1 SYNE2	9.19e-03	73	37	2	PS50021
Domain	CH-domain	SYNE1 SYNE2	9.68e-03	75	37	2	IPR001715
Domain	IQ	IQCF5 IQCF1	1.12e-02	81	37	2	SM00015
Domain	IQ_motif_EF-hand-BS	IQCF5 IQCF1	1.37e-02	90	37	2	IPR000048
Pathway	WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY	ADCY3 SYNE1 SYNE2	8.02e-05	46	26	3	M39828
Pathway	KEGG_MEDICUS_REFERENCE_HEPARAN_SULFATE_BIOSYNTHESIS	EXTL1 EXTL3	1.78e-04	11	26	2	M47921
Pubmed	Multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds.	SYNE1 SYNE2	1.10e-06	2	37	2	22768332
Pubmed	Human tumor suppressor EXT gene family members EXTL1 and EXTL3 encode alpha 1,4- N-acetylglucosaminyltransferases that likely are involved in heparan sulfate/ heparin biosynthesis.	EXTL1 EXTL3	1.10e-06	2	37	2	11390981
Pubmed	Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity.	SYNE1 SYNE2	1.10e-06	2	37	2	17761684
Pubmed	Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation.	SYNE1 SYNE2	1.10e-06	2	37	2	17267447
Pubmed	Nesprin-1-alpha2 associates with kinesin at myotube outer nuclear membranes, but is restricted to neuromuscular junction nuclei in adult muscle.	SYNE1 SYNE2	1.10e-06	2	37	2	31578382
Pubmed	Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues.	SYNE1 SYNE2	1.10e-06	2	37	2	11792814
Pubmed	Nesprins: tissue-specific expression of epsilon and other short isoforms.	SYNE1 SYNE2	1.10e-06	2	37	2	24718612
Pubmed	Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response.	SYNE1 SYNE2	1.10e-06	2	37	2	24586179
Pubmed	Nesprin-1 and nesprin-2 regulate endothelial cell shape and migration.	SYNE1 SYNE2	1.10e-06	2	37	2	24931616
Pubmed	Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction.	SYNE1 SYNE2	3.30e-06	3	37	2	10878022
Pubmed	Distinct functional domains in nesprin-1alpha and nesprin-2beta bind directly to emerin and both interactions are disrupted in X-linked Emery-Dreifuss muscular dystrophy.	SYNE1 SYNE2	3.30e-06	3	37	2	17462627
Pubmed	Structures of FHOD1-Nesprin1/2 complexes reveal alternate binding modes for the FH3 domain of formins.	SYNE1 SYNE2	3.30e-06	3	37	2	33472039
Pubmed	Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells.	SYNE1 SYNE2	3.30e-06	3	37	2	25516977
Pubmed	The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope.	SYNE1 SYNE2	3.30e-06	3	37	2	16079285
Pubmed	The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300.	SYNE1 SYNE2	3.30e-06	3	37	2	12408964
Pubmed	Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	TBC1D12 SFI1 EXTL3 ADCY3	4.80e-06	105	37	4	9628581
Pubmed	LINC complexes mediate the positioning of cone photoreceptor nuclei in mouse retina.	SYNE1 SYNE2	6.60e-06	4	37	2	23071752
Pubmed	Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton.	SYNE1 SYNE2	6.60e-06	4	37	2	19596800
Pubmed	Outer nuclear membrane protein Kuduk modulates the LINC complex and nuclear envelope architecture.	SYNE1 SYNE2	6.60e-06	4	37	2	28716842
Pubmed	SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton.	SYNE1 SYNE2	6.60e-06	4	37	2	16648470
Pubmed	Nesprins, but not sun proteins, switch isoforms at the nuclear envelope during muscle development.	SYNE1 SYNE2	6.60e-06	4	37	2	20108321
Pubmed	Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness.	SYNE1 SYNE2	1.10e-05	5	37	2	18396275
Pubmed	LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteins.	SYNE1 SYNE2	1.10e-05	5	37	2	22632968
Pubmed	Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.	SYNE1 SYNE2	1.65e-05	6	37	2	33058875
Pubmed	TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton.	SYNE1 SYNE2	1.65e-05	6	37	2	18827015
Pubmed	Identification of functional variants for cleft lip with or without cleft palate in or near PAX7, FGFR2, and NOG by targeted sequencing of GWAS loci.	NTN1 NOG	1.65e-05	6	37	2	25704602
Pubmed	Nesprin 1α2 is essential for mouse postnatal viability and nuclear positioning in skeletal muscle.	SYNE1 SYNE2	4.93e-05	10	37	2	28533284
Pubmed	Nuclear membrane proteins with potential disease links found by subtractive proteomics.	SYNE1 SYNE2	4.93e-05	10	37	2	12958361
Pubmed	A conserved KASH domain protein associates with telomeres, SUN1, and dynactin during mammalian meiosis.	SYNE1 SYNE2	6.02e-05	11	37	2	22826121
Pubmed	The BMP antagonist Noggin promotes cranial and spinal neurulation by distinct mechanisms.	NTN1 NOG	6.02e-05	11	37	2	16712836
Pubmed	KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development.	SYNE1 SYNE2	8.53e-05	13	37	2	21177258
Pubmed	SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice.	SYNE1 SYNE2	9.94e-05	14	37	2	19874786
Pubmed	Genome-wide association study of alcohol dependence implicates a region on chromosome 11.	ADCY3 SYNE1	9.94e-05	14	37	2	20201924
Pubmed	Loss of the neurodevelopmental gene Zswim6 alters striatal morphology and motor regulation.	ZSWIM6 ZSWIM5	1.86e-04	19	37	2	28433741
Pubmed	Large-scale cDNA transfection screening for genes related to cancer development and progression.	LARGE2 WDR59 ABHD11	2.46e-04	114	37	3	15498874
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	EXTL1 EXTL3 LRBA ASB16	4.06e-04	329	37	4	17474147
Pubmed	Proximity labelling identifies pro-migratory endocytic recycling cargo and machinery of the Rab4 and Rab11 families.	ARFGEF1 LRBA SYNE1 VAT1	4.54e-04	339	37	4	37232246
Pubmed	Upregulation of μ3A Drives Homeostatic Plasticity by Rerouting AMPAR into the Recycling Endosomal Pathway.	ARFGEF1 USP48	4.70e-04	30	37	2	27568566
Pubmed	Integration of repulsive guidance cues generates avascular zones that shape mammalian blood vessels.	NTN1 NOG	5.02e-04	31	37	2	22076636
Pubmed	Lem2 is essential for cardiac development by maintaining nuclear integrity.	SYNE1 SYNE2	5.35e-04	32	37	2	37067297
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	IQCF5 GSTK1 ZSWIM5 VARS1 SYNE1 SYNE2 VAT1	7.17e-04	1442	37	7	35575683
Pubmed	Hes genes and neurogenin regulate non-neural versus neural fate specification in the dorsal telencephalic midline.	ARFGEF1 NOG	7.56e-04	38	37	2	18579678
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ZSWIM6 ZSWIM5 ADCY3 SYNE1	8.99e-04	407	37	4	12693553
Cytoband	3p21.2	IQCF5 IQCF1	1.07e-04	19	37	2	3p21.2
Cytoband	10q23.33	TBC1D12 CYP26C1	1.58e-04	23	37	2	10q23.33
GeneFamily	Spectrin repeat containing nuclear envelope family	SYNE1 SYNE2	1.10e-05	4	25	2	1252
GeneFamily	Exostosin glycosyltransferase family	EXTL1 EXTL3	1.83e-05	5	25	2	431
GeneFamily	Zinc fingers SWIM-type\|Mitogen-activated protein kinase kinase kinases	ZSWIM6 ZSWIM5	6.57e-05	9	25	2	90
GeneFamily	WD repeat domain containing\|BEACH domain containing	LRBA WDFY4	6.57e-05	9	25	2	1230
GeneFamily	WD repeat domain containing	LRBA WDFY4 WDR59	5.47e-03	262	25	3	362
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ARFGEF1 SFI1 LRBA SYNE1 SYNE2	6.25e-07	199	37	5	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	3'_v3-blood-Lymphocytic_T_CD4-T_CD4/CD8\|blood / Manually curated celltypes from each tissue	SFI1 LRBA SYNE1 SYNE2	4.74e-06	135	37	4	ae2d3a42e567b5bade304c0caa497eb725be3565
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLURP1 ESYT3 EXTL1 SYNE2	1.10e-05	167	37	4	d50311b1f66f143bae4c4cf50e2e9b13c85d6920
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLURP1 ESYT3 EXTL1 SYNE2	1.10e-05	167	37	4	7abc785e688a384672d7fb5a62d32538fe7e5a51
ToppCell	COVID-19_Severe-CD4+_CTL\|World / disease group, cell group and cell class	EXTL1 ASB16 SYNE1 SYNE2	1.15e-05	169	37	4	8c8168ac93a808d7b4756e4491db2b2979df1c1f
ToppCell	Globus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	TMEM130 SPIRE2 PTCHD4 ASB16	1.26e-05	173	37	4	7e3897868dd3f6e4974f593c60649a543ffc8693
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZSWIM6 NOG EXTL3 SYNE1	1.32e-05	175	37	4	1d8aab491dcc27ea5dbfb6462d18ee280b21a05e
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZSWIM6 NOG EXTL3 SYNE1	1.32e-05	175	37	4	427a7ee92fe16a90625946492062d37aa0f7235b
ToppCell	Adult-Epithelial-club_cell-D122\|Adult / Lineage, Cell type, age group and donor	KLK11 NTN1 TMEM130 SYNE2	1.41e-05	178	37	4	35a2e3ba98b6f857dbb79cf8ddb4846ddcda6c17
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Ductal_Carcinoma-1\|TCGA-Breast / Sample_Type by Project: Shred V9	ARFGEF1 LRBA ZSWIM5 ASB16	1.71e-05	187	37	4	a716b64ca03d9b61da765bf87f065ac9393303f1
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_ASM_(13)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	RHCG NTN1 NOG PTCHD4	1.75e-05	188	37	4	f54b063025d80de631382bf5326bc40aab7f7d00
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_ASM_(13)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	NTN1 NOG PTCHD4 UNC45B	1.82e-05	190	37	4	938d1f66094b1c94606e0d40213a39e5112f3322
ToppCell	Control-Epithelial-Basal/Club\|Control / Disease group,lineage and cell class （2021.01.30）	RHCG KLK11 LARGE2 PTPRH	1.82e-05	190	37	4	799b0b1c4bdbe04ee0fc34d0be9e02b5992774a0
ToppCell	severe-low-quality_cells\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SFI1 LRBA SYNE1 SYNE2	1.94e-05	193	37	4	9337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCell	Children_(3_yrs)-Epithelial-club_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	KLK11 NTN1 TMEM130 SYNE2	2.02e-05	195	37	4	dccc32fcf772e2504de7f663ef0a5bd8e23e92fc
ToppCell	mild-low-quality_cells\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SFI1 LRBA SYNE1 SYNE2	2.10e-05	197	37	4	e4331969bd911d1ebb5453f40a7057297b5389b4
ToppCell	TCGA-Bladder-Solid_Tissue_Normal-Urothelial_normal_tissue-Urothelial_normal_tissue-6\|TCGA-Bladder / Sample_Type by Project: Shred V9	SLURP1 RHCG KLK11	1.59e-04	127	37	3	d61b71572eab8a850ee8ce54323fb247525006e5
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RHCG NTN1 PTCHD4	1.91e-04	135	37	3	52b5c664c0b7a303c6084d508748dcb6c38a0c23
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RHCG C1orf167 PTPRH	2.26e-04	143	37	3	990844ca674d30b2924c74b45bed4fdfb8463fa7
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_naive-B_naive-13\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	LARGE2 NTN1 WDFY4	2.30e-04	144	37	3	b2a9f3b5dd46d27689467f4a5fd717cd5827821f
ToppCell	Bronchial_Biopsy-Epithelial-Goblet_1\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	RHCG C1orf167 PTPRH	2.35e-04	145	37	3	e932361734839c14ffa0c1e028dcef9c833f884f
ToppCell	Bronchial_Biopsy-Epithelial-Goblet_1\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	RHCG C1orf167 PTPRH	2.40e-04	146	37	3	a4f2e3ea79e7154873c01739672ec6454547e6a6
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Chrna2_Glra3\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TMEM130 PTCHD4 VAT1	2.45e-04	147	37	3	50e86860a94be103092c40e39a172eac92372f0d
ToppCell	COVID-19_Moderate-multiplets\|World / disease group, cell group and cell class	SFI1 SYNE1 SYNE2	2.91e-04	156	37	3	afdc025fa75e7926b1cc182c4a33654a2186abb1
ToppCell	10x5'-Lung-Lymphocytic_T_CD4-T_CD4/CD8\|Lung / Manually curated celltypes from each tissue	ESYT3 LRBA SYNE2	2.91e-04	156	37	3	10d191e29b16cae8238e8df6c0ff38882253f34e
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Degenerative_Medullary_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RHCG LARGE2 ASB16	2.91e-04	156	37	3	d34f386985dd17293b1e320d732ab11b46be76ce
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	RHCG NTN1 ZSWIM6	2.97e-04	157	37	3	c17c5c01fcb65c453690c265ec4f300ecdfefd34
ToppCell	Healthy/Control-CD8+_T_naive\|World / Disease group and Cell class	SFI1 NOG ZSWIM5	3.02e-04	158	37	3	70680b29428b6bf882b1fae36f924b775961176b
ToppCell	Healthy/Control-CD8+_T_naive\|Healthy/Control / Disease group and Cell class	SFI1 NOG ZSWIM5	3.14e-04	160	37	3	e1386c21fcbbf57fa32d8bdfba3cb1887477ff73
ToppCell	IPF-Epithelial-Ionocyte\|IPF / Disease state, Lineage and Cell class	SLURP1 NTN1 CYP26C1	3.14e-04	160	37	3	d65d19f4fae60836bfd4303a1bb7de34e9d83e35
ToppCell	Club_cells-HP_01\|World / lung cells shred on cell class, cell subclass, sample id	KLK11 NTN1 TMEM130	3.20e-04	161	37	3	bd08a23b415617f6e8748ed2668d578a860ecf91
ToppCell	IPF-Epithelial-Ionocyte\|World / Disease state, Lineage and Cell class	SLURP1 NTN1 CYP26C1	3.20e-04	161	37	3	f1cd5c938cdc08ad8995371b72493850a6cf277a
ToppCell	10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8\|blood / Manually curated celltypes from each tissue	SFI1 LRBA SYNE2	3.25e-04	162	37	3	b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCell	droplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFI1 WDFY4 ADCY3	3.31e-04	163	37	3	8dc0128eeede933537e3bcc5d6ec0322711552f3
ToppCell	normal-na-Lymphocytic_T-T4_reg-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	LRBA UNC45B SYNE2	3.31e-04	163	37	3	43887e7687fc6367efac0c1f56a9534b06f47b7f
ToppCell	droplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFI1 WDFY4 ADCY3	3.31e-04	163	37	3	fd243ca223079033be480a24817a399f281fa4d4
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Dendritic-CD1c-positive_myeloid_dendritic_cell-DC2_(CD1c+_dendritic_cell)-DC2_L.1.2.1.3\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TBC1D12 WDFY4 ADCY3	3.43e-04	165	37	3	76abebe80e5f8bf44825bb619ae86fcb6f66ffeb
ToppCell	Adult-Epithelial-lung_goblet_cell-D122\|Adult / Lineage, Cell type, age group and donor	KLK11 NTN1 TMEM130	3.56e-04	167	37	3	6efbb2ef6adc8da5dd67210969f825f5cc8ed022
ToppCell	PND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLURP1 EXTL1 SYNE2	3.56e-04	167	37	3	351f8de1fbdf742ac74f9099b254d515ab539bb2
ToppCell	PND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLURP1 EXTL1 SYNE2	3.56e-04	167	37	3	c042d6cdddd0e1ddef1e3ac6f4fe23151127b0f2
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c07-TYROBP\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	ASB16 SYNE1 SYNE2	3.56e-04	167	37	3	ded4d6cccd3660662f12cf5a512de31d26325f1b
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	ESYT3 SYNE1 SYNE2	3.62e-04	168	37	3	b94b1f37c92e019d01ecfa3b7cc6797b6e4a56ff
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_11\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	NTN1 MBOAT4 WDFY4	3.68e-04	169	37	3	e3410ccb3f85811c75694e286115803911169a2f
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_11\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NTN1 MBOAT4 WDFY4	3.68e-04	169	37	3	a4f610d07c3ba5537f4497f523669b914f7eddc1
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RHCG NTN1 ZSWIM6	3.68e-04	169	37	3	2a21f2cef959526bfe3c8f081f4f7e9dd4e01a37
ToppCell	droplet-Kidney-nan-3m-Lymphocytic-CD45____B_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EXTL1 WDFY4 VARS1	3.75e-04	170	37	3	6210ee3bf29059e6149c047bb7e02c5f59441519
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	SFI1 SYNE1 SYNE2	3.81e-04	171	37	3	2e9a20f8980b78325c52065a9c14ab3656267c05
ToppCell	mild-Myeloid-Eosinophils\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	TMEM130 SYNE1 SYNE2	3.81e-04	171	37	3	5c8198182495bda7a826e9d80aa467f4eb1094ec
ToppCell	droplet-Lung-LUNG-30m-Myeloid-Myeloid_Dendritic_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLK11 ESYT3 WDFY4	3.88e-04	172	37	3	a5344760b10ecdc0101f78b93b8fc0f8107068c5
ToppCell	390C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	TBC1D12 KLK11 ASB16	3.94e-04	173	37	3	1f725ff16e28636b20ef26f3fa9be8b47c89378d
ToppCell	facs-Heart-LV-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EXTL3 ZSWIM5 ADCY3	3.94e-04	173	37	3	d78397e65e997ddb995111a810f0e2a4f67d0765
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLURP1 ESYT3 SYNE2	3.94e-04	173	37	3	3725525b99a6011eda2ff5459b4fd2e1eab1f090
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NTN1 EXTL1 EXTL3	3.94e-04	173	37	3	f612d4ea9ab8dcde475f4118bca3e49be786e7fa
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NTN1 EXTL1 EXTL3	3.94e-04	173	37	3	c62e3ffed55bbb00dcaef6da0aab8446f3f55085
ToppCell	droplet-Lung-30m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_type_2\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	KLK11 ESYT3 WDFY4	3.94e-04	173	37	3	70c0c13febd28b395fb3171ec8d7fbbc6c9d4eb7
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	EXTL3 PTPRH UNC45B	3.94e-04	173	37	3	3001dd39244ef0a5a475d569a78f4ae427a55db6
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLURP1 ESYT3 SYNE2	3.94e-04	173	37	3	ee7d1429f23f1b89a9a9f7bc07a84a44cf7acd1c
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	EXTL3 PTPRH UNC45B	3.94e-04	173	37	3	c88883fb2a33e21d4201aa393674aa3f2ad780c9
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLURP1 EXTL1 SYNE2	3.94e-04	173	37	3	30d67738633493d47f06ae452424382f069b6c0a
ToppCell	facs-Heart-LV-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EXTL3 ZSWIM5 ADCY3	3.94e-04	173	37	3	3c852ffe22f4a5b632463086b08c669310684e80
ToppCell	facs-Pancreas-Exocrine-18m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NTN1 EXTL1 EXTL3	4.01e-04	174	37	3	165e14cad57e90aa247dcecfaa3c2e8ff2a470ad
ToppCell	facs-Pancreas-Exocrine-18m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NTN1 EXTL1 EXTL3	4.01e-04	174	37	3	4289dfc7613db4bb3d706b9b65d06e84c0c53558
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLURP1 EXTL1 SYNE2	4.01e-04	174	37	3	a9c6edf5c3fc119c24425f921c5566a8356c30fe
ToppCell	droplet-Kidney-nan-3m-Lymphocytic-B_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EXTL1 WDFY4 VARS1	4.01e-04	174	37	3	ce9bdd02dc8eb45ba9c1481619c0089b465e6442
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARFGEF1 SYNE1 SYNE2	4.08e-04	175	37	3	cf53a15bfb37b6019e7052ffdf594a9ac040900e
ToppCell	systemic_lupus_erythematosus-flare-Myeloid-conventional_dendritic_cell-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	C1orf167 PTCHD4 MBOAT4	4.08e-04	175	37	3	c58a1f02d1e559d3638fe1500e960e82a8a7187b
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLURP1 RHCG KLK11	4.08e-04	175	37	3	8252ddc2ca95071381f0354aefb70c4714828491
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLURP1 RHCG KLK11	4.08e-04	175	37	3	8ccf60fc469059d7aaf4e6ce54159db2962e0060
ToppCell	Caecum-Dendritic_cell-cDC1\|Dendritic_cell / Region, Cell class and subclass	SFI1 WDFY4 ADCY3	4.15e-04	176	37	3	07cde50e1c18fcc2c5028efe1a087db4ef4d4783
ToppCell	Club_cells-IPF_02\|World / lung cells shred on cell class, cell subclass, sample id	KLK11 NTN1 SYNE2	4.15e-04	176	37	3	88c4ed0ab4a4ede8cad21385d799b723b5786cd9
ToppCell	droplet-Fat-SCAT-30m-Mesenchymal-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLURP1 NTN1 SPIRE2	4.29e-04	178	37	3	5cf12927f0756c4d8a289fe4308d736382e6212e
ToppCell	Club_cells-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	SLURP1 KLK11 NTN1	4.29e-04	178	37	3	be64d4be23fb96a4cdd7980c58880fdfe817747f
ToppCell	COVID-19-kidney-Epi_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	TMEM130 PTCHD4 SYNE1	4.36e-04	179	37	3	e7c9dc63f03d3f3746b51a7e3c8393089e2ceb7d
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_G2M\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLURP1 ESYT3 EXTL1	4.36e-04	179	37	3	adf8b025032a03dbb58871a92025cd7efbeb22ff
ToppCell	Control-Lymphoid-T_Regulatory\|World / Disease state, Lineage and Cell class	LRBA USP48 SYNE2	4.43e-04	180	37	3	47036eee4c128fbb443d1fc767b4de5cced93f0e
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8\|Liver / Manually curated celltypes from each tissue	SFI1 LRBA SYNE2	4.50e-04	181	37	3	f2315414e714ac86211546a935660c4be6e85f1b
ToppCell	Control-Lymphoid-T_Regulatory\|Control / Disease state, Lineage and Cell class	LRBA USP48 SYNE2	4.57e-04	182	37	3	31bb838cc2900f3c9da9f835d79d557a08abb928
ToppCell	Children_(3_yrs)-Epithelial-club_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	KLK11 NTN1 TMEM130	4.57e-04	182	37	3	215c303df42f13597b2c7a95cb157c6bc7aca9a1
ToppCell	Globus_pallidus-Neuronal-Inhibitory\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	TMEM130 PTCHD4 ASB16	4.57e-04	182	37	3	04ccfa951eaa31fed6d140edb6c702d49363c5fa
ToppCell	droplet-Marrow-BM-30m-Lymphocytic-naive_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY3 ABHD11 VAT1	4.57e-04	182	37	3	8b16a13d8606d21a7a9ce1175237e9b4cf832ee0
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage-macrophage,_alveolar-Macro_c1-C1QC\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	WDFY4 ADCY3 VAT1	4.79e-04	185	37	3	0e8064bb317f26959d3c59b4f73d0c455161ccd7
ToppCell	COPD-Lymphoid-T_Regulatory\|COPD / Disease state, Lineage and Cell class	LRBA USP48 SYNE2	4.79e-04	185	37	3	846403edd4c8f646201d519055198fc38b7ffff9
ToppCell	facs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	IQCF5 NOG PTCHD4	4.87e-04	186	37	3	bdc87e4631a8ea73e262e541aa84a28f24c94b00
ToppCell	Adult-Epithelial-club_cell-D231\|Adult / Lineage, Cell type, age group and donor	KLK11 NTN1 TMEM130	4.95e-04	187	37	3	ee59d7d3de5879738ff0b9c3ea5e4847fb48cb86
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-lymphocytic-T_lymphocytic-effector_CD4-positive,_alpha-beta_T_cell\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	NOG SYNE1 SYNE2	4.95e-04	187	37	3	e61c1755531469dd3850c9740474b5ad4e0499c1
ToppCell	human_hepatoblastoma-Tumor_cells-T2\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	LRBA ZSWIM5 WDR59	4.95e-04	187	37	3	f3e37c18ac6471c7992609bbddfa4975571c815c
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	RHCG NTN1 NOG	4.95e-04	187	37	3	387cb27c8a20031cd87381a9e1172f1f62e1488b
ToppCell	droplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l20-25\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SLURP1 NTN1 VAT1	4.95e-04	187	37	3	0d4b7da81036c2aa678654b9fe49c939d08fcd9b
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	RHCG NTN1 NOG	5.02e-04	188	37	3	c29aaae3c5bb7cd6b9b3defd4d27afde3af19ba0
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	ARFGEF1 LRBA SYNE2	5.02e-04	188	37	3	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_ASM_(13)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	RHCG NTN1 NOG	5.10e-04	189	37	3	da9ecc0d7b81c1901f30f97bb44112dc85444a66
ToppCell	IPF-Epithelial-Club\|IPF / Disease state, Lineage and Cell class	KLK11 NTN1 PTCHD4	5.10e-04	189	37	3	f3fcef008ef252b29ac6d567fef27f9acf9cd70f
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	RHCG NTN1 NOG	5.10e-04	189	37	3	0abc7a4900cc9033bc1be69b770ccc54a6bf41b4
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW09-Neuronal-Neuron\|GW09 / Sample Type, Dataset, Time_group, and Cell type.	TBC1D12 USP48 VAT1	5.10e-04	189	37	3	3717d1148e26ac78a26aea0ca1dbfbb9d3668877
ToppCell	CF-Lymphoid-B_cell\|CF / Disease state, Lineage and Cell class	LRBA USP48 WDFY4	5.18e-04	190	37	3	374d8fd63c733178acab07682ed1519693efab45
ToppCell	Adult-Epithelial-club_cell\|Adult / Lineage, Cell type, age group and donor	KLK11 NTN1 TMEM130	5.18e-04	190	37	3	756bff697d30aec56c0ebfca94295f084a15bf37
ToppCell	BL-critical-LOC-Epithelial-Secretory\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	KLK11 NTN1 PTPRH	5.18e-04	190	37	3	f2abe4bc28e934287e2dcd7b9399d5af78c5c8cf
ToppCell	Basal_cells-IPF_02\|World / lung cells shred on cell class, cell subclass, sample id	KLK11 LARGE2 NTN1	5.26e-04	191	37	3	a98915bad9a4a61dd4cbca798914849b805f4a19
ToppCell	11.5-Airway-Epithelial-Neuroendocrine\|Airway / Age, Tissue, Lineage and Cell class	KLK11 LARGE2 PTPRH	5.26e-04	191	37	3	c1bb3ae5c297f55cdadf5b6e53d5296389d5099e
ToppCell	mild_COVID-19-gd_T\|mild_COVID-19 / disease group, cell group and cell class (v2)	PTCHD4 SYNE1 SYNE2	5.26e-04	191	37	3	0e43c097b92aaa831811d60e033262999e79dcd7
Drug	AC1L4QOR	SLURP1 LRBA	7.70e-06	3	37	2	CID000162096
Disease	Autosomal dominant Emery-Dreifuss muscular dystrophy	SYNE1 SYNE2	8.19e-06	4	35	2	cv:CN293514
Disease	hereditary multiple exostoses (implicated_via_orthology)	EXTL1 EXTL3	8.19e-06	4	35	2	DOID:206 (implicated_via_orthology)
Disease	Autosomal Recessive Emery-Dreifuss Muscular Dystrophy	SYNE1 SYNE2	1.36e-05	5	35	2	C1450051
Disease	Autosomal Dominant Emery-Dreifuss Muscular Dystrophy (disorder)	SYNE1 SYNE2	1.36e-05	5	35	2	C0410190
Disease	Emery-Dreifuss muscular dystrophy	SYNE1 SYNE2	2.04e-05	6	35	2	cv:C0410189
Disease	Muscular Dystrophy, Emery-Dreifuss	SYNE1 SYNE2	2.04e-05	6	35	2	C0410189
Disease	X-Linked Emery-Dreifuss Muscular Dystrophy	SYNE1 SYNE2	2.86e-05	7	35	2	C0751337
Disease	Emery-Dreifuss muscular dystrophy (implicated_via_orthology)	SYNE1 SYNE2	8.95e-05	12	35	2	DOID:11726 (implicated_via_orthology)
Disease	cleft lip	NTN1 NOG WDR59 SYNE1	3.48e-04	284	35	4	EFO_0003959
Disease	female fertility, fertility measurement	ZSWIM6 SYNE1	7.05e-04	33	35	2	EFO_0006918, EFO_0006923
Disease	orofacial cleft	NTN1 NOG	8.87e-04	37	35	2	MONDO_0000358

Protein segments in the cluster

Peptide	Gene	Start	Entry
MRSTRRVRELWWQGL	TBC1D12	471	O60347
MRCVTRTRNWWRRAA	nan	1	Q6ZRU5
ALLWMWWRRNRRGKL	ESYT3	66	A0FGR9
LLWKMRLFQRQWANS	C1orf167	791	Q5SNV9
QQRMLQRSLRWWHLR	C1orf167	811	Q5SNV9
QLASMLRWTRAWRLP	ABHD11	6	Q8NFV4
NMGRIRLQWSRIWEV	ARFGEF1	1176	Q9Y6D6
SMLRSLRLQQEWLEW	ASB16	11	Q96NS5
SLVIQWRDTWARRLR	NTN1	576	O95631
WAAVTLQSQARMWRI	IQCF1	126	Q8N6M8
LRLDRLRQAGWEQMW	LARGE2	261	Q8N3Y3
LRQAGWEQMWRLTAR	LARGE2	266	Q8N3Y3
WEQMWRLTARRELLS	LARGE2	271	Q8N3Y3
MQRLRWLRDWKSSGR	KLK11	1	Q9UBX7
NRRSLLQCSVWQEWM	LRBA	856	P50851
AVRLQSWVRMWCVRQ	IQCF5	71	A8MTL0
LRWSNRIRLTWLSFT	EXTL3	21	O43909
KASRELWMRVWSRNE	GSTK1	116	Q9Y2Q3
TRWARNTWAMLAIFI	ADCY3	701	O60266
HLWTLRWMLSRDRAS	CYP26C1	31	Q6V0L0
WNQSTARWLRRLVFQ	MBOAT4	306	Q96T53
WRFQKTRQTWLLLHM	C7orf50	116	Q9BRJ6
LTLMASWNQRARWLR	PKD1L1	2601	Q8TDX9
LRRKLQMWLWSQTFC	NOG	141	Q13253
AWMDNIREWCISRQL	VARS1	711	P26640
QRIILRVWWSTWRQR	SFI1	216	A8K8P3
LSRSMTTVWQRWTRL	SYNE1	5181	Q8NF91
QARWQMSARKALLLW	SYNE2	176	Q8WXH0
ASWIWWRMLRQVLRR	PTCHD4	11	Q6ZW05
MASRWAVQLLLVAAW	SLURP1	1	P55000
MQSWRRRKSLWLALS	EXTL1	1	Q92935
KWLCNMSIDTRTRRW	UNC45B	516	Q8IWX7
TLSTLNWRRREMVRW	ZSWIM5	876	Q9P217
DWARLWVQLMRELRR	SPIRE2	241	Q8WWL2
LSVIRTMWAWNARNF	WDFY4	406	Q6ZS81
MAWNTNLRWRLPLTC	RHCG	1	Q9UBD6
QLVTWSRDQTLRMWR	WDR59	301	Q6PJI9
RNLMALARTWWNQFS	VAT1	296	Q99536
TLSTLNWRRREMVRW	ZSWIM6	906	Q9HCJ5
MAQAVWSRLGRILWL	TMEM130	1	Q8N3G9
MAPRLQLEKAAWRWA	USP48	1	Q86UV5
LLAFWRMLRQWLDQT	PTPRH	996	Q9HD43