Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	metalloendopeptidase activity	EEF1AKMT4-ECE2 MMEL1 ADAMTS3 ADAMTS2 MME ECE2	1.60e-06	120	60	6	GO:0004222
GeneOntologyMolecularFunction	metallopeptidase activity	EEF1AKMT4-ECE2 MMEL1 ADAMTS3 ADAMTS2 MME ECE2	2.99e-05	200	60	6	GO:0008237
GeneOntologyMolecularFunction	activin receptor activity, type I	TGFBR1 ACVR1C	8.83e-05	5	60	2	GO:0016361
GeneOntologyMolecularFunction	activin receptor activity	TGFBR1 ACVR1C	3.15e-04	9	60	2	GO:0017002
GeneOntologyMolecularFunction	guanylate kinase activity	MPP1 CASK	4.80e-04	11	60	2	GO:0004385
GeneOntologyMolecularFunction	activin binding	TGFBR1 ACVR1C	5.75e-04	12	60	2	GO:0048185
GeneOntologyMolecularFunction	protein kinase C binding	ADCY4 ADCY6 CASK	1.03e-03	66	60	3	GO:0005080
GeneOntologyMolecularFunction	water channel activity	AQP4 AQP7	1.17e-03	17	60	2	GO:0015250
GeneOntologyMolecularFunction	adenylate cyclase activity	ADCY4 ADCY6	1.32e-03	18	60	2	GO:0004016
GeneOntologyMolecularFunction	transmembrane receptor protein serine/threonine kinase activity	TGFBR1 ACVR1C	1.63e-03	20	60	2	GO:0004675
GeneOntologyMolecularFunction	water transmembrane transporter activity	AQP4 AQP7	1.63e-03	20	60	2	GO:0005372
GeneOntologyMolecularFunction	endopeptidase activity	EEF1AKMT4-ECE2 MMEL1 ADAMTS3 ADAMTS2 MME ECE2	1.81e-03	430	60	6	GO:0004175
GeneOntologyMolecularFunction	nucleoside monophosphate kinase activity	MPP1 CASK	2.16e-03	23	60	2	GO:0050145
GeneOntologyMolecularFunction	cyclase activity	ADCY4 ADCY6	2.35e-03	24	60	2	GO:0009975
GeneOntologyMolecularFunction	phosphorus-oxygen lyase activity	ADCY4 ADCY6	2.55e-03	25	60	2	GO:0016849
GeneOntologyMolecularFunction	filamin binding	XIRP1 DPYSL4	3.42e-03	29	60	2	GO:0031005
GeneOntologyBiologicalProcess	renal water homeostasis	AQP4 AQP7 ADCY6	5.80e-05	26	60	3	GO:0003091
GeneOntologyBiologicalProcess	GMP metabolic process	MPP1 XDH CASK	1.20e-04	33	60	3	GO:0046037
GeneOntologyBiologicalProcess	one-carbon compound transport	RHBG AQP4 AQP7	1.20e-04	33	60	3	GO:0019755
GeneOntologyBiologicalProcess	multicellular organismal-level chemical homeostasis	HEPHL1 AQP4 AQP7 ADCY6	1.37e-04	90	60	4	GO:0140962
GeneOntologyBiologicalProcess	multicellular organismal-level water homeostasis	AQP4 AQP7 ADCY6	1.43e-04	35	60	3	GO:0050891
GeneOntologyBiologicalProcess	protein processing	EEF1AKMT4-ECE2 MMEL1 ADAMTS3 ADAMTS2 MME ECE2	1.77e-04	285	60	6	GO:0016485
GeneOntologyCellularComponent	activin receptor complex	TGFBR1 ACVR1C	1.29e-04	6	62	2	GO:0048179
GeneOntologyCellularComponent	cell-cell junction	MPP1 TGFBR1 XIRP1 AMOTL2 AQP4 AQP7 CASK CDC42EP1	3.43e-04	591	62	8	GO:0005911
GeneOntologyCellularComponent	basolateral plasma membrane	TGFBR1 ABCC3 RHBG AQP4 AQP7 CASK	3.67e-04	320	62	6	GO:0016323
GeneOntologyCellularComponent	basal plasma membrane	TGFBR1 ABCC3 RHBG AQP4 AQP7 CASK	6.25e-04	354	62	6	GO:0009925
GeneOntologyCellularComponent	basal part of cell	TGFBR1 ABCC3 RHBG AQP4 AQP7 CASK	8.80e-04	378	62	6	GO:0045178
Domain	Peptidase_M13	MMEL1 MME ECE2	1.09e-06	7	60	3	PF01431
Domain	Peptidase_M13_C	MMEL1 MME ECE2	1.09e-06	7	60	3	IPR018497
Domain	Peptidase_M13	MMEL1 MME ECE2	1.09e-06	7	60	3	IPR000718
Domain	Peptidase_M13_N	MMEL1 MME ECE2	1.09e-06	7	60	3	PF05649
Domain	Peptidase_M13_N	MMEL1 MME ECE2	1.09e-06	7	60	3	IPR008753
Domain	MetalloPept_cat_dom	MMEL1 ADAMTS3 ADAMTS2 MME ECE2	6.13e-06	81	60	5	IPR024079
Domain	-	MMEL1 ADAMTS3 ADAMTS2 MME ECE2	6.13e-06	81	60	5	3.40.390.10
Domain	ZINC_PROTEASE	MMEL1 ADAMTS3 ADAMTS2 MME ECE2	1.56e-05	98	60	5	PS00142
Domain	Adcy_conserved_dom	ADCY4 ADCY6	1.51e-04	6	60	2	IPR009398
Domain	DUF1053	ADCY4 ADCY6	1.51e-04	6	60	2	PF06327
Domain	GS	TGFBR1 ACVR1C	2.11e-04	7	60	2	SM00467
Domain	GS_dom	TGFBR1 ACVR1C	2.11e-04	7	60	2	IPR003605
Domain	GS	TGFBR1 ACVR1C	2.11e-04	7	60	2	PS51256
Domain	TGF_beta_GS	TGFBR1 ACVR1C	2.11e-04	7	60	2	PF08515
Domain	AC_N	ADCY4 ADCY6	2.81e-04	8	60	2	IPR032628
Domain	Adcy	ADCY4 ADCY6	2.81e-04	8	60	2	IPR030672
Domain	AC_N	ADCY4 ADCY6	2.81e-04	8	60	2	PF16214
Domain	Activin_recp	TGFBR1 ACVR1C	4.49e-04	10	60	2	IPR000472
Domain	Activin_recp	TGFBR1 ACVR1C	4.49e-04	10	60	2	PF01064
Domain	TGFB_receptor	TGFBR1 ACVR1C	6.56e-04	12	60	2	IPR000333
Domain	MIP	AQP4 AQP7	9.01e-04	14	60	2	PS00221
Domain	MIP	AQP4 AQP7	9.01e-04	14	60	2	PF00230
Domain	MIP	AQP4 AQP7	1.04e-03	15	60	2	IPR000425
Domain	-	AQP4 AQP7	1.04e-03	15	60	2	1.20.1080.10
Domain	Aquaporin-like	AQP4 AQP7	1.04e-03	15	60	2	IPR023271
Domain	Guanylate_kinase_CS	MPP1 CASK	1.18e-03	16	60	2	IPR020590
Domain	A/G_cyclase_CS	ADCY4 ADCY6	1.34e-03	17	60	2	IPR018297
Domain	Nucleotide_cyclase	ADCY4 ADCY6	1.50e-03	18	60	2	IPR029787
Domain	-	ADCY4 ADCY6	1.50e-03	18	60	2	3.30.70.1230
Domain	PLAC	ADAMTS3 ADAMTS2	1.68e-03	19	60	2	PS50900
Domain	GUANYLATE_CYCLASE_1	ADCY4 ADCY6	1.68e-03	19	60	2	PS00452
Domain	Guanylate_cyc	ADCY4 ADCY6	1.68e-03	19	60	2	PF00211
Domain	GUANYLATE_CYCLASE_2	ADCY4 ADCY6	1.68e-03	19	60	2	PS50125
Domain	PLAC	ADAMTS3 ADAMTS2	1.68e-03	19	60	2	IPR010909
Domain	A/G_cyclase	ADCY4 ADCY6	1.68e-03	19	60	2	IPR001054
Domain	CYCc	ADCY4 ADCY6	1.68e-03	19	60	2	SM00044
Domain	CRIB	CDC42SE1 CDC42EP1	1.86e-03	20	60	2	PS50108
Domain	CRIB_dom	CDC42SE1 CDC42EP1	2.05e-03	21	60	2	IPR000095
Domain	ADAM_spacer1	ADAMTS3 ADAMTS2	2.46e-03	23	60	2	IPR010294
Domain	GUANYLATE_KINASE_2	MPP1 CASK	2.46e-03	23	60	2	PS50052
Domain	GUANYLATE_KINASE_1	MPP1 CASK	2.46e-03	23	60	2	PS00856
Domain	ADAM_spacer1	ADAMTS3 ADAMTS2	2.46e-03	23	60	2	PF05986
Domain	Peptidase_M12B_ADAM-TS	ADAMTS3 ADAMTS2	2.68e-03	24	60	2	IPR013273
Domain	Guanylate_kin	MPP1 CASK	3.14e-03	26	60	2	PF00625
Domain	GK/Ca_channel_bsu	MPP1 CASK	3.14e-03	26	60	2	IPR008145
Domain	Guanylate_kin-like_dom	MPP1 CASK	3.14e-03	26	60	2	IPR008144
Domain	GuKc	MPP1 CASK	3.14e-03	26	60	2	SM00072
Domain	LIPASE_SER	PLA1A MGLL	3.14e-03	26	60	2	PS00120
Domain	Ser/Thr_kinase_AS	TGFBR1 SIK3 ACVR1C NEK9 CASK	5.73e-03	357	60	5	IPR008271
Domain	S_TKc	TGFBR1 SIK3 ACVR1C NEK9 CASK	5.87e-03	359	60	5	SM00220
Domain	PROTEIN_KINASE_ST	TGFBR1 SIK3 ACVR1C NEK9 CASK	6.07e-03	362	60	5	PS00108
Pathway	REACTOME_AQUAPORIN_MEDIATED_TRANSPORT	ADCY4 AQP4 AQP7 ADCY6	2.40e-05	52	46	4	M920
Pathway	REACTOME_VASOPRESSIN_REGULATES_RENAL_WATER_HOMEOSTASIS_VIA_AQUAPORINS	ADCY4 AQP4 ADCY6	3.66e-04	43	46	3	M933
Pathway	REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY	ADCY4 ADCY6	4.61e-04	10	46	2	M19522
Pathway	REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY	ADCY4 ADCY6	4.61e-04	10	46	2	MM14668
Pathway	REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS	AQP4 AQP7	7.94e-04	13	46	2	MM15095
Pathway	REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS	AQP4 AQP7	7.94e-04	13	46	2	M911
Pathway	REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY	ADCY4 ADCY6	9.25e-04	14	46	2	MM14669
Pathway	REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY	ADCY4 ADCY6	9.25e-04	14	46	2	M750
Pathway	REACTOME_COLLAGEN_BIOSYNTHESIS_AND_MODIFYING_ENZYMES	COL4A3 ADAMTS3 ADAMTS2	1.03e-03	61	46	3	MM14637
Pathway	KEGG_MEDICUS_REFERENCE_EP_NE_ADRB_CAMP_SIGNALING_PATHWAY	ADCY4 ADCY6	1.06e-03	15	46	2	M47794
Pathway	PID_LPA4_PATHWAY	ADCY4 ADCY6	1.06e-03	15	46	2	M56
Pathway	KEGG_MEDICUS_REFERENCE_PTH_PTH1R_PKA_SIGNALING_PATHWAY	ADCY4 ADCY6	1.06e-03	15	46	2	M47504
Pathway	WP_MAJOR_RECEPTORS_TARGETED_BY_EPINEPHRINE_AND_NOREPINEPHRINE	ADCY4 ADCY6	1.21e-03	16	46	2	M39849
Pathway	KEGG_MEDICUS_REFERENCE_LHCGR_GNAS_PKA_SIGNALING_PATHWAY	ADCY4 ADCY6	1.21e-03	16	46	2	M47645
Pathway	KEGG_MEDICUS_REFERENCE_FSHR_GNAS_PKA_SIGNALING_PATHWAY	ADCY4 ADCY6	1.21e-03	16	46	2	M47650
Pathway	REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB	ADCY4 ADCY6	1.21e-03	16	46	2	MM14492
Pathway	REACTOME_COLLAGEN_BIOSYNTHESIS_AND_MODIFYING_ENZYMES	COL4A3 ADAMTS3 ADAMTS2	1.35e-03	67	46	3	M26999
Pathway	REACTOME_PKA_ACTIVATION_IN_GLUCAGON_SIGNALLING	ADCY4 ADCY6	1.37e-03	17	46	2	M26995
Pathway	KEGG_MEDICUS_REFERENCE_CX3CR1_GNAI_AC_PKA_SIGNALING_PATHWAY	ADCY4 ADCY6	1.37e-03	17	46	2	M47544
Pubmed	Human neprilysin-2 (NEP2) and NEP display distinct subcellular localisations and substrate preferences.	MMEL1 MME	3.13e-06	2	62	2	18539150
Pubmed	Human endothelin converting enzyme-2 (ECE2): characterization of mRNA species and chromosomal localization.	EEF1AKMT4-ECE2 ECE2	3.13e-06	2	62	2	11718899
Pubmed	Sustained Activation of Rho GTPases Promotes a Synthetic Pulmonary Artery Smooth Muscle Cell Phenotype in Neprilysin Null Mice.	MMEL1 MME	3.13e-06	2	62	2	29191928
Pubmed	Aquaporins (water channels): role in vasopressin-activated water transport.	AQP4 AQP7	3.13e-06	2	62	2	9824541
Pubmed	In silico based investigation of dynamic variations in neprilysin (NEP and NEP2) proteins for extracting the point of specificity.	MMEL1 MME	3.13e-06	2	62	2	26846903
Pubmed	The procollagen N-proteinases ADAMTS2, 3 and 14 in pathophysiology.	ADAMTS3 ADAMTS2	9.37e-06	3	62	2	25863161
Pubmed	Attenuation of cerebral edema facilitates recovery of glymphatic system function after status epilepticus.	TRPM4 AQP4	9.37e-06	3	62	2	34494549
Pubmed	SUR1-TRPM4 and AQP4 form a heteromultimeric complex that amplifies ion/water osmotic coupling and drives astrocyte swelling.	TRPM4 AQP4	9.37e-06	3	62	2	28906027
Pubmed	Cloning and characterization of ADAMTS-14, a novel ADAMTS displaying high homology with ADAMTS-2 and ADAMTS-3.	ADAMTS3 ADAMTS2	9.37e-06	3	62	2	11741898
Pubmed	Postanoxic damage of microglial cells is mediated by xanthine oxidase and cyclooxygenase.	XDH PTGS1	9.37e-06	3	62	2	17364940
Pubmed	Induction of human ADAMTS-2 gene expression by IL-1α is mediated by a multiple crosstalk of MEK/JNK and PI3K pathways in osteoblast like cells.	ADAMTS3 ADAMTS2	9.37e-06	3	62	2	26232334
Pubmed	IL-6 upregulates a disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAMTS-2) in human osteosarcoma cells mediated by JNK pathway.	ADAMTS3 ADAMTS2	9.37e-06	3	62	2	24752352
Pubmed	Neprilysin-2 is an important β-amyloid degrading enzyme.	MMEL1 MME	9.37e-06	3	62	2	21224067
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	TGFBR1 TRPM4 PDPR RTCB PYROXD2 MACF1 MGLL LTBR NEK9 ADCY6	1.71e-05	1061	62	10	33845483
Pubmed	Pancreatic islet and progenitor cell surface markers with cell sorting potential.	TGFBR1 SLC38A10 DISP2 LTBR	1.74e-05	86	62	4	21947380
Pubmed	Expression and localisation of aquaporin water channels in human urothelium in situ and in vitro.	AQP4 AQP7	1.87e-05	4	62	2	18718702
Pubmed	Role of protein kinase C-dependent A-kinase anchoring proteins in lysophosphatidic acid-induced cAMP signaling in human diploid fibroblasts.	ADCY4 ADCY6	1.87e-05	4	62	2	17081159
Pubmed	ADAMTS: a novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats.	ADAMTS3 ADAMTS2	1.87e-05	4	62	2	10094461
Pubmed	Expression of ADAMTS-2, -3, -13, and -14 in culprit coronary lesions in patients with acute myocardial infarction or stable angina.	ADAMTS3 ADAMTS2	1.87e-05	4	62	2	22205175
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ABCC3 TRPM4 RADIL SLC38A10 CELSR3 TULP4 MORN1 FBXL14 DISP2 MBD5	2.41e-05	1105	62	10	35748872
Pubmed	Regulation of steady-state beta-amyloid levels in the brain by neprilysin and endothelin-converting enzyme but not angiotensin-converting enzyme.	MME ECE2	3.12e-05	5	62	2	16912050
Pubmed	[ADAMTS family--new extracellular matrix degrading enzyme].	ADAMTS3 ADAMTS2	3.12e-05	5	62	2	11831030
Pubmed	Human bronchial smooth muscle cells express adenylyl cyclase isoforms 2, 4, and 6 in distinct membrane microdomains.	ADCY4 ADCY6	3.12e-05	5	62	2	21228062
Pubmed	More than just water channels: unexpected cellular roles of aquaporins.	AQP4 AQP7	3.12e-05	5	62	2	16079275
Pubmed	Mammalian adenylyl cyclase family members are randomly located on different chromosomes.	ADCY4 ADCY6	3.12e-05	5	62	2	7959689
Pubmed	Regulation of procollagen amino-propeptide processing during mouse embryogenesis by specialization of homologous ADAMTS proteases: insights on collagen biosynthesis and dermatosparaxis.	ADAMTS3 ADAMTS2	4.67e-05	6	62	2	16556917
Pubmed	Mapping of adenylyl cyclase genes type I, II, III, IV, V, and VI in mouse.	ADCY4 ADCY6	4.67e-05	6	62	2	7766992
Pubmed	Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland.	ADCY4 ADCY6	4.67e-05	6	62	2	11549699
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	ERGIC1 TRPM4 TULP4 MORN1 MACF1 MGLL LTBR MME MBD5 NEK9 CASK	5.81e-05	1489	62	11	28611215
Pubmed	Differential expression of adenylyl cyclase mRNAs in lacrimal glands of NZB/NZW and NOD pre-autoimmune mice.	ADCY4 ADCY6	6.53e-05	7	62	2	12613887
Pubmed	Role of aquaporin water channels in kidney and lung.	AQP4 AQP7	6.53e-05	7	62	2	9822113
Pubmed	Lessons on renal physiology from transgenic mice lacking aquaporin water channels.	AQP4 AQP7	6.53e-05	7	62	2	10232700
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	PDXDC1 MPP1 ABCC3 TRPM4 ADCY6 CASK CDC42EP1	6.83e-05	569	62	7	30639242
Pubmed	Growth differentiation factor 11 signals through the transforming growth factor-beta receptor ALK5 to regionalize the anterior-posterior axis.	TGFBR1 ACVR1C	8.69e-05	8	62	2	16845371
Pubmed	Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS.	ADCY4 ADCY6	1.12e-04	9	62	2	9417641
Pubmed	Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms.	ADCY4 ADCY6	1.12e-04	9	62	2	12503609
Pubmed	A disintegrin and metalloproteinase with thrombospondin motifs 2 cleaves and inactivates Reelin in the postnatal cerebral cortex and hippocampus, but not in the cerebellum.	ADAMTS3 ADAMTS2	1.12e-04	9	62	2	31491533
Pubmed	Tgf-beta3-induced palatal fusion is mediated by Alk-5/Smad pathway.	TGFBR1 ACVR1C	1.12e-04	9	62	2	14729481
Pubmed	Role of the calcium modulated cyclases in the development of the retinal projections.	ADCY4 ADCY6	1.12e-04	9	62	2	17229090
Pubmed	Aquaporin molecular biology and clinical abnormalities of the water transport channels.	AQP4 AQP7	1.12e-04	9	62	2	9757370
Pubmed	Purification and characterization of a soluble form of mammalian adenylyl cyclase.	ADCY4 ADCY6	1.39e-04	10	62	2	8663304
Pubmed	Comprehensive analysis of the expression patterns of the adenylate cyclase gene family in the developing and adult mouse brain.	ADCY4 ADCY6	1.39e-04	10	62	2	16615126
Pubmed	Expression of mRNAs of the aquaporin family in mouse oocytes and embryos.	AQP4 AQP7	1.39e-04	10	62	2	10788316
Pubmed	Aquaporin-6: An intracellular vesicle water channel protein in renal epithelia.	AQP4 AQP7	1.39e-04	10	62	2	10318966
Pubmed	Expression patterns of aquaporins in the inner ear: evidence for concerted actions of multiple types of aquaporins to facilitate water transport in the cochlea.	AQP4 AQP7	1.39e-04	10	62	2	12031518
Pubmed	ADAMTS: a novel family of extracellular matrix proteases.	ADAMTS3 ADAMTS2	1.39e-04	10	62	2	11167130
Pubmed	Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons.	ADCY4 ADCY6	1.39e-04	10	62	2	11884542
Pubmed	mRNAs encoding aquaporins are present during murine preimplantation development.	AQP4 AQP7	1.39e-04	10	62	2	11066060
Pubmed	Molecular cloning and characterization of an aquaporin cDNA from salivary, lacrimal, and respiratory tissues.	AQP4 AQP7	1.70e-04	11	62	2	7530250
Pubmed	Water permeability and characterization of aquaporin-11.	AQP4 AQP7	1.70e-04	11	62	2	21251984
Pubmed	Roles of aquaporin-3 water channels in volume-regulatory water flow in a human epithelial cell line.	AQP4 AQP7	1.70e-04	11	62	2	16596446
Pubmed	Novel variants in human Aquaporin-4 reduce cellular water permeability.	AQP4 AQP7	1.70e-04	11	62	2	18511455
Pubmed	Reconstitution of functional water channels in liposomes containing purified red cell CHIP28 protein.	AQP4 AQP7	1.70e-04	11	62	2	1510932
Pubmed	Mercury-sensitive residues and pore site in AQP3 water channel.	AQP4 AQP7	1.70e-04	11	62	2	9369468
Pubmed	Appearance of water channels in Xenopus oocytes expressing red cell CHIP28 protein.	AQP4 AQP7	1.70e-04	11	62	2	1373524
Pubmed	Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures.	ADCY4 ADCY6	1.70e-04	11	62	2	11299302
Pubmed	Functional characterization and localization of AQP3 in the human colon.	AQP4 AQP7	1.70e-04	11	62	2	10510269
Pubmed	Aquaporin-1, nothing but a water channel.	AQP4 AQP7	1.70e-04	11	62	2	14701836
Pubmed	Mechanism of selectivity in aquaporins and aquaglyceroporins.	AQP4 AQP7	1.70e-04	11	62	2	18202181
Pubmed	Functional characterization of human aquaporin 9 as a facilitative glycerol carrier.	AQP4 AQP7	1.70e-04	11	62	2	18762715
Pubmed	Functional and molecular characterization of the human neutral solute channel aquaporin-9.	AQP4 AQP7	1.70e-04	11	62	2	10564231
Pubmed	Functional characterization of a human aquaporin 0 mutation that leads to a congenital dominant lens cataract.	AQP4 AQP7	1.70e-04	11	62	2	18501347
Pubmed	Cloning and functional expression of human aquaporin8 cDNA and analysis of its gene.	AQP4 AQP7	1.70e-04	11	62	2	9806845
Pubmed	Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1.	ADCY4 ADCY6	1.70e-04	11	62	2	10089566
Pubmed	Structural determinants of water permeation through aquaporin-1.	AQP4 AQP7	1.70e-04	11	62	2	11034202
Pubmed	Cloning of a new aquaporin (AQP10) abundantly expressed in duodenum and jejunum.	AQP4 AQP7	1.70e-04	11	62	2	11573934
Pubmed	Functional impairment of lens aquaporin in two families with dominantly inherited cataracts.	AQP4 AQP7	1.70e-04	11	62	2	11001937
Pubmed	gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression.	ADCY4 ADCY6	1.70e-04	11	62	2	10808179
Pubmed	Purification and functional characterization of aquaporin-8.	AQP4 AQP7	1.70e-04	11	62	2	15948717
Pubmed	Identification of arylsulfonamides as Aquaporin 4 inhibitors.	AQP4 AQP7	1.70e-04	11	62	2	17178220
Pubmed	Bidirectional water fluxes and specificity for small hydrophilic molecules in aquaporins 0-5.	AQP4 AQP7	1.70e-04	11	62	2	9829975
Pubmed	The subcellular localization of an aquaporin-2 tetramer depends on the stoichiometry of phosphorylated and nonphosphorylated monomers.	AQP4 AQP7	1.70e-04	11	62	2	11076974
Pubmed	Cloning and identification of a new member of water channel (AQP10) as an aquaglyceroporin.	AQP4 AQP7	1.70e-04	11	62	2	12084581
Pubmed	Molecular cloning and expression of a novel human aquaporin from adipose tissue with glycerol permeability.	AQP4 AQP7	1.70e-04	11	62	2	9405233
Pubmed	Composition and Regulation of the Cellular Repertoire of SCF Ubiquitin Ligases.	CAND2 FBXL14 FBXW5	1.89e-04	62	62	3	29103612
Pubmed	Genetic analysis of genes involved in amyloid-β degradation and clearance in Alzheimer's disease.	MMEL1 ECE2	2.04e-04	12	62	2	22027013
Pubmed	Expression of adenylyl cyclase mRNAs in the denervated and in the developing mouse skeletal muscle.	ADCY4 ADCY6	2.04e-04	12	62	2	9611134
Pubmed	Signaling through the TGF beta-activin receptors ALK4/5/7 regulates testis formation and male germ cell development.	TGFBR1 ACVR1C	2.04e-04	12	62	2	23342175
Pubmed	HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones.	ADCY4 ADCY6	2.04e-04	12	62	2	10807185
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ERGIC1 RADIL TULP4 MACF1 MBD5 NEK9	2.47e-04	493	62	6	15368895
Pubmed	Isoforms of mammalian adenylyl cyclase: multiplicities of signaling.	ADCY4 ADCY6	2.81e-04	14	62	2	14993377
Pubmed	cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes.	ADCY4 ADCY6	3.23e-04	15	62	2	2165385
Pubmed	Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method.	PDPR NEK9	3.23e-04	15	62	2	12056414
Pubmed	Aquaporins 8 and 9 as Possible Markers for Adult Murine Lacrimal Gland Cells.	AQP4 AQP7	3.23e-04	15	62	2	34540996
Pubmed	ADAMTS2 promotes radial migration by activating TGF-β signaling in the developing neocortex.	ADAMTS3 ADAMTS2	3.23e-04	15	62	2	38871984
Pubmed	Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning.	ADCY4 ADCY6	3.69e-04	16	62	2	17567809
Pubmed	ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family.	ADAMTS3 ADAMTS2	4.18e-04	17	62	2	10464288
Pubmed	Polyhydramnios in Lrp4 knockout mice with bilateral kidney agenesis: Defects in the pathways of amniotic fluid clearance.	AQP4 AQP7	4.18e-04	17	62	2	26847765
Pubmed	Expression patterns of the aquaporin gene family during renal development: influence of genetic variability.	AQP4 AQP7	5.24e-04	19	62	2	19367412
Pubmed	Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.	PDXDC1 MPP1 FAM171B CASK CDC42EP1	5.68e-04	377	62	5	38117590
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	PCED1B FARSA RTCB ZNF324 DPYSL4 MACF1 SIK3 CASK	6.53e-04	1082	62	8	38697112
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	RADIL RTCB MACF1 SIK3 NEK9 PPP1R12C CDC42EP1	8.38e-04	861	62	7	36931259
Pubmed	Myocardial Angiopoietin-1 Controls Atrial Chamber Morphogenesis by Spatiotemporal Degradation of Cardiac Jelly.	ADAMTS3 ADAMTS2	8.41e-04	24	62	2	29791855
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	PDXDC1 MACF1 FAM171B CASK CDC42EP1	9.32e-04	421	62	5	36976175
Pubmed	Characterization of carbonic anhydrase IX interactome reveals proteins assisting its nuclear localization in hypoxic cells.	CAND2 RTCB	9.89e-04	26	62	2	23181366
Pubmed	Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purification.	ADCY4 PTGS1	1.23e-03	29	62	2	24003143
Pubmed	Glucagon and regulation of glucose metabolism.	ADCY4 ADCY6	1.41e-03	31	62	2	12626323
Pubmed	The utility and predictive value of combinations of low penetrance genes for screening and risk prediction of colorectal cancer.	TGFBR1 PTGS1	1.50e-03	32	62	2	20437058
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	CELSR3 MACF1 MBD5	1.64e-03	130	62	3	12421765
Pubmed	BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.	PDXDC1 ERGIC1 FARSA RTCB MACF1 HEPHL1	1.66e-03	711	62	6	33022573
GeneFamily	Type 1 receptor serine/threonine kinases	TGFBR1 ACVR1C	8.04e-05	7	36	2	345
GeneFamily	Adenylate cyclases\|Deafness associated genes	ADCY4 ADCY6	1.72e-04	10	36	2	53
GeneFamily	Aquaporins	AQP4 AQP7	3.46e-04	14	36	2	305
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS3 ADAMTS2	6.45e-04	19	36	2	50
GeneFamily	Calcium voltage-gated channel subunits\|Membrane associated guanylate kinases	MPP1 CASK	1.22e-03	26	36	2	904
GeneFamily	PDZ domain containing	MPP1 RADIL CASK	3.39e-03	152	36	3	1220
Coexpression	LAKE_ADULT_KIDNEY_C2_PODOCYTES	PCED1B COL4A3 MACF1 MME SIK3 MBD5	1.00e-05	212	61	6	M39221
ToppCell	facs-BAT-Fat-18m-Endothelial\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY4 XDH MGLL AMOTL2 AQP7 CDC42EP1	2.55e-07	192	61	6	3a99c521c599a289ee2309d97be5ceb99f8aa220
ToppCell	facs-Thymus-Epithelium-24m-Endothelial\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY4 MGLL LTBR AQP7 PTGS1 CDC42EP1	2.55e-07	192	61	6	39afea574725ce0c67afdd79facdb34f819a828d
ToppCell	facs-BAT-Fat-18m-Endothelial-endothelial_cell\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY4 XDH MGLL AMOTL2 AQP7 CDC42EP1	2.55e-07	192	61	6	f9777e0fdd86c2a514f05a42502888329a94b396
ToppCell	facs-Thymus-Epithelium-24m-Endothelial-endothelial_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY4 MGLL LTBR AQP7 PTGS1 CDC42EP1	2.55e-07	192	61	6	597db951b1fbc37db22134c3d27d3ec4ceaa85f7
ToppCell	facs-Thymus-Epithelium-24m-Endothelial-endothelial_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY4 MGLL LTBR AQP7 PTGS1 CDC42EP1	2.55e-07	192	61	6	bc275a9eccb1c7a46fd58b15ca5acdd9f7495842
ToppCell	facs-BAT-Fat-18m-Endothelial-nan\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY4 XDH MGLL AMOTL2 AQP7 CDC42EP1	2.55e-07	192	61	6	562e15876088af9189744c9b2de5c4863d7f15fd
ToppCell	E16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-Mature_Fibroblast_1\|E16.5-samps / Age Group, Lineage, Cell class and subclass	PLA1A ADAMTS2 XDH MACF1 MME	2.96e-06	163	61	5	f1ec2625b52664308968b01d8e0275e1e0751480
ToppCell	megakaryocytic\|World / Lineage and Cell class	MPP1 ABCC3 MGLL PTGS1 ADCY6	5.35e-06	184	61	5	b1c630ca2189d9d49402a5621b57618976fbea5c
ToppCell	droplet-Heart-nan-18m-Endothelial-endothelial_cell_of_coronary_artery\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY4 XDH MGLL AQP7 CDC42EP1	5.94e-06	188	61	5	9dfa2e0b73640459cdf88277291e3ab9c33e0217
ToppCell	facs-Pancreas-Exocrine-3m-Endothelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY4 ZNF366 XDH MGLL PTGS1	6.26e-06	190	61	5	b7fc451e160e31dc898b122de844b501f587db67
ToppCell	facs-Pancreas-Exocrine-3m-Endothelial-endothelial_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY4 ZNF366 XDH MGLL PTGS1	6.26e-06	190	61	5	83cc851fb9f644b17a8ebf4d99a646003769a22f
ToppCell	facs-Pancreas-Exocrine-3m-Endothelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY4 ZNF366 XDH MGLL PTGS1	6.26e-06	190	61	5	5f440d4b334d66d419c03bd828f7d93f16c1ce67
ToppCell	LV-10._Endothelium_II\|LV / Chamber and Cluster_Paper	PCED1B ADCY4 PLA1A ZNF366 PTGS1	6.92e-06	194	61	5	b6cc849fa08599bff9839ef382d190cc964e273e
ToppCell	facs-Thymus-Epithelium\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY4 DISP2 MGLL AQP7 CDC42EP1	6.92e-06	194	61	5	255d6eead8da740a942a5e7d554dbd895d736d1a
ToppCell	proximal-Endothelial-Capillary-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ADCY4 PLA1A ZNF366 FBXL14 ACVR1C	7.46e-06	197	61	5	ddb8ea895f0f34d4f20a0740b708fa0f3e378801
ToppCell	proximal-Endothelial-Capillary\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ADCY4 PLA1A ZNF366 FBXL14 ACVR1C	7.46e-06	197	61	5	53baef54bd85c60ae24a3c163b3a3d937fb6ff0b
ToppCell	proximal-3-Endothelial-Capillary\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ADCY4 PLA1A ZNF366 FBXL14 ACVR1C	7.46e-06	197	61	5	a1a61c03d67272693ec23e0d15f0a12bf618e2da
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_macrophage\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MPP1 ABCC3 ADAMTS2 MGLL LTBR	7.83e-06	199	61	5	b827dd8a249f904a0ff930a6c4d3b00fb7bc6fb1
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_macrophage-macrophage\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MPP1 ABCC3 ADAMTS2 MGLL LTBR	7.83e-06	199	61	5	c0dcdda30485bb920d3706dcfb06f11b76b6ea37
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_3\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	COL4A3 ZNF366 FAM171B PTGS1	5.48e-05	151	61	4	0b6b37734430918378ed94e40877f0c4ae9b25ec
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_3\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	COL4A3 ZNF366 FAM171B PTGS1	5.48e-05	151	61	4	30225a1a7800b0ae19e16ac164f561379eedb99d
ToppCell	Entopeduncular-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1-MURAL_Mural.Rgs5Acta2.Junb_(Mural,_IEG+)\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	COL4A3 XIRP1 CAND2 PYROXD2	6.22e-05	156	61	4	029ba0832ee9c4a2c85620e4df2260e02d86b45c
ToppCell	Entopeduncular-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1-MURAL_Mural.Rgs5Acta2.Junb_(Mural,_IEG+)-\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	COL4A3 XIRP1 CAND2 PYROXD2	6.22e-05	156	61	4	5df19a235843829f5a1a90ca21b0964ef8b4e115
ToppCell	droplet-Marrow-nan-18m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY4 XIRP1 FBXL14 AQP7	7.03e-05	161	61	4	3f3a2148c8d65e6a06f8d8116a3aa58dda17d618
ToppCell	facs-Marrow-Granulocytes-18m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY4 MORN1 HEPHL1 ADCY6	7.03e-05	161	61	4	60f433eab9d5531bdf6aa86b0265f20b866b904c
ToppCell	368C-Myeloid-Dendritic-cDC_activated\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	FBXL14 MGLL AMOTL2 ADCY6	7.55e-05	164	61	4	67c636a2cc32e56c6186dc7e779cc19af04639d2
ToppCell	E18.5-samps-Mesenchymal-Matrix_fibroblast-MatrixFB-A\|E18.5-samps / Age Group, Lineage, Cell class and subclass	PCED1B ADAMTS2 MACF1 MME	7.55e-05	164	61	4	519ab4fe885dfe4c50846f346a062acc2cb44299
ToppCell	droplet-Kidney-nan-18m-Epithelial-Epcam____brush_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL4A3 ABCC3 MME AQP4	8.10e-05	167	61	4	ed7e785dcd25777f64e0c2596ada4f5a5ea17121
ToppCell	facs-Heart-RV-24m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY4 MGLL AQP7 CDC42EP1	8.29e-05	168	61	4	831b000e26b4a7e7fdfa3988372e0281c45eadbb
ToppCell	droplet-Kidney-nan-18m-Epithelial-brush_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL4A3 ABCC3 MME AQP4	8.48e-05	169	61	4	f00741203efa0b948db7223ee8c19bdd0918258a
ToppCell	droplet-Lung-1m-Hematologic-myeloid-interstitial_macrophage\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ABCC3 CAND2 MORN1 PTGS1	8.68e-05	170	61	4	f664c7559e383b37845c123e41a3be316d869ba0
ToppCell	droplet-Lung-1m-Hematologic-myeloid-interstitial_macrophage-interstitial_macrophage_l12\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ABCC3 CAND2 MORN1 PTGS1	8.68e-05	170	61	4	0272eb1487c2545d4aa06f5d1cd77f823e1441e9
ToppCell	droplet-Kidney-nan-21m-Epithelial-brush_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCC3 MME AQP4 AQP7	8.88e-05	171	61	4	007f148f4611ea1826edfa9f91ced36541ad9f5a
ToppCell	droplet-Kidney-nan-21m-Epithelial-Epcam____brush_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCC3 MME AQP4 AQP7	8.88e-05	171	61	4	8e7223ba447947cdf4e1c82a52fd90439cf3d8f6
ToppCell	metastatic_Lymph_Node-Myeloid_cells-Microglia/Mac\|metastatic_Lymph_Node / Location, Cell class and cell subclass	ADAMTS2 ZNF324 CRAT PTGS1	9.08e-05	172	61	4	f673a2e697b46e7cfa4186cb3fb2b98e3c83703e
ToppCell	10x5'-bone_marrow-Hematopoietic_Erythro-Mega-Erythrocytic-Meg\|bone_marrow / Manually curated celltypes from each tissue	MPP1 MGLL PTGS1 ADCY6	9.08e-05	172	61	4	deda14ba1e760dd46a5e129683d415436e74deb6
ToppCell	droplet-Fat-Scat-21m-Endothelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY4 MGLL AQP7 CDC42EP1	9.29e-05	173	61	4	f13124b4cf2ac1dc2895f90f5487d6ac681b0ba4
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Interstitial_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGFBR1 ABCC3 MORN1 PTGS1	9.29e-05	173	61	4	26bba58f9fb215d1d155504906cd77e8774f6936
ToppCell	droplet-Lung-LUNG-1m-Myeloid-lung_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGFBR1 ABCC3 MORN1 PTGS1	9.29e-05	173	61	4	69b404e92aad3e6dff67e75466f073f20a71f13f
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-basophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRPM4 PLA1A CYP21A2 ACVR1C	9.29e-05	173	61	4	3612772632ddf11eb48579cae9a8ccab6b3f1f52
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Basophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRPM4 PLA1A CYP21A2 ACVR1C	9.29e-05	173	61	4	4dc261ebcdb9bdcfca1451da1bd254f0dc5de203
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-5_RORB_CD24\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PCED1B ABCC3 ADAMTS3 MME	9.50e-05	174	61	4	3e29d620b7b4ab1915ddac70ee5a50d09072292b
ToppCell	droplet-Pancreas-Exocrine-24m-Epithelial-pancreatic_ductal_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RHBG DPYSL4 AMOTL2 CDC42EP1	9.71e-05	175	61	4	6bb8fc2959583644f16b22e906af91af62a3a633
ToppCell	droplet-Pancreas-Exocrine-24m-Epithelial-pancreatic_ductal_cel\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RHBG DPYSL4 AMOTL2 CDC42EP1	9.71e-05	175	61	4	8902c38067f025b094ca9c28c449c32a66eded1c
ToppCell	facs-Kidney-nan-18m-Epithelial-epithelial_cell_of_proximal_tubule\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL4A3 ABCC3 MME AQP4	9.71e-05	175	61	4	076ad81d6cbeea5512393d192af3ab5aa1f82975
ToppCell	facs-Kidney-nan-18m-Epithelial-epithelial_cell_of_proximal_tubule\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL4A3 ABCC3 MME AQP4	9.71e-05	175	61	4	445ccb9744a3a9ff37164c532afbe769d306b6c8
ToppCell	10x5'-lymph-node_spleen-Hematopoietic_Erythro-Mega\|lymph-node_spleen / Manually curated celltypes from each tissue	MPP1 ABCC3 MGLL PTGS1	9.71e-05	175	61	4	5ca3369ce2c2bb88ba097260195aecd67cec1a3a
ToppCell	10x5'-lymph-node_spleen-Hematopoietic_Erythro-Mega-Megakaryocyte_early\|lymph-node_spleen / Manually curated celltypes from each tissue	MPP1 ABCC3 MGLL PTGS1	9.92e-05	176	61	4	50fe3fd862dd6a6550ebb8c27f337cde468efedc
ToppCell	facs-Diaphragm-Limb_Muscle-18m-Endothelial-nan\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY4 XDH MGLL AQP7	9.92e-05	176	61	4	a3f27b5d7edf2d396c085efbe35305cfa0afa565
ToppCell	droplet-Pancreas-Exocrine-24m\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPYSL4 XDH AMOTL2 CDC42EP1	1.01e-04	177	61	4	a5b54792ef948a1e1de66301a60e051250189f59
ToppCell	facs-Brain_Myeloid-Striatum\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGFBR1 ABCC3 MACF1 PTGS1	1.01e-04	177	61	4	efb1990fd1d216f64261e81017299783afb24a1e
ToppCell	IIF-Other-Platelet\|IIF / Disease, Lineage and Cell Type	MPP1 ABCC3 MGLL PTGS1	1.04e-04	178	61	4	529c0d2159e539546876246122f2e999170a6b20
ToppCell	RV-11._Adipocyte\|RV / Chamber and Cluster_Paper	PCED1B MME ACVR1C AQP7	1.04e-04	178	61	4	278bbea5cf8f0589f71675c7a3d00679391b5253
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.2.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MGLL AMOTL2 AQP4 CDC42EP1	1.04e-04	178	61	4	f3b5eeca6081d65d48824b5d13e3b8eb5fdeb2dd
ToppCell	5'-Adult-LymphNode-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADCY4 RADIL PLA1A FAM171B	1.04e-04	178	61	4	4b3ea0921bc598ebb9f63780ecdf8ad4349f3666
ToppCell	PBMC-Convalescent-Hematopoietic-Platelet-Platelet-plt_3\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MPP1 ABCC3 MGLL PTGS1	1.04e-04	178	61	4	850fcd368c4478c57eaedc74544773ea220f41f3
ToppCell	facs-Trachea-24m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l7\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GLYCTK MGLL AQP7 CDC42EP1	1.04e-04	178	61	4	a3f95f0002f408b5b6c57e28b297b5b2737e919c
ToppCell	PBMC-Convalescent-Hematopoietic-Platelet-Platelet-plt_3\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	MPP1 ABCC3 MGLL PTGS1	1.04e-04	178	61	4	a16857da9f2907c176213a326112a1b4cbd0e628
ToppCell	5'-Adult-LymphNode-Endothelial-lymphatic_endothelial-LEC6_(ADAMTS4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADCY4 RADIL PLA1A FAM171B	1.06e-04	179	61	4	9fd9b136ecbcbd4e4f0d5875ede98d8d48608afb
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Mesenchymal-Mes\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL4A3 ADCY4 LTBR CDC42EP1	1.06e-04	179	61	4	368f7e91e9c2c854c8778788cead022d158d1122
ToppCell	3'_v3-lymph-node_spleen-Hematopoietic_Erythro-Mega\|lymph-node_spleen / Manually curated celltypes from each tissue	MPP1 ABCC3 MGLL PTGS1	1.06e-04	179	61	4	4e0cf069bc47328eda753a4edc7e89b8915d52bb
ToppCell	facs-Heart-RV-24m-Endothelial-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY4 MGLL AQP7 CDC42EP1	1.06e-04	179	61	4	6aa211670e5d6e013d0980967aa0a4f8f2905efe
ToppCell	facs-GAT-Fat-18m-Endothelial\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGLL HEPHL1 AQP7 CDC42EP1	1.06e-04	179	61	4	d56fa2a0b119d51a8d41b00fbbd7dfddefeb279c
ToppCell	facs-GAT-Fat-18m-Endothelial-endothelial_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGLL HEPHL1 AQP7 CDC42EP1	1.06e-04	179	61	4	e0542694fa79d67f67be6f85b4fa6d18f7523253
ToppCell	facs-Heart-RV-24m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY4 MGLL AQP7 CDC42EP1	1.06e-04	179	61	4	cf4d3828a3ce97932c68d06f5c65a070fc6d832c
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Mesenchymal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL4A3 ADCY4 LTBR CDC42EP1	1.06e-04	179	61	4	11e434fc49bc0a806197f21debcac8337e0502aa
ToppCell	facs-Heart-RV-24m-Endothelial-endothelial_cell_of_coronary_artery\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY4 MGLL AQP7 CDC42EP1	1.06e-04	179	61	4	f9bc76ff25f88ee44c72499a0df9dc16f519c4cb
ToppCell	facs-GAT-Fat-18m-Endothelial-nan\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGLL HEPHL1 AQP7 CDC42EP1	1.06e-04	179	61	4	83343b68977969c7978acd930a66fc7c44df6a15
ToppCell	3'_v3-blood-Hematopoietic_Erythro-Mega-Megakaryocyte_early\|blood / Manually curated celltypes from each tissue	MPP1 ABCC3 MGLL PTGS1	1.06e-04	179	61	4	290772eece76d70555dca8b8d82bd88b47e2fc35
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TGFBR1 ADAMTS3 RHBG AQP7	1.06e-04	179	61	4	d3438fed0d85d5ed5afa8ff820c45143d77b6c0d
ToppCell	COVID-19_Convalescent-Hematopoietic_Mega-Platelet\|COVID-19_Convalescent / Disease group, lineage and cell class	MPP1 ABCC3 MGLL PTGS1	1.08e-04	180	61	4	deed53167504c91220b35a63366ed7d8f02a5254
ToppCell	facs-Lung-EPCAM-24m-Myeloid-Dendritic_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RADIL MMEL1 ADAMTS3 MME	1.08e-04	180	61	4	5b7d2336ed09d07f6b8dd91c1fa9c5ade633c104
ToppCell	COVID-19_Convalescent-Hematopoietic_Mega\|COVID-19_Convalescent / Disease group, lineage and cell class	MPP1 ABCC3 MGLL PTGS1	1.08e-04	180	61	4	17323d382ae322e388e230fdad13e3464ea73e8e
ToppCell	facs-Lung-24m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RADIL MMEL1 ADAMTS3 MME	1.08e-04	180	61	4	d33bb00f2b7d07dda9015cb8eafd742c2b2e9ace
ToppCell	AT1-AT2_cells-Donor_05\|World / lung cells shred on cell class, cell subclass, sample id	COL4A3 AMOTL2 AQP4 LHX9	1.11e-04	181	61	4	ca23ce4f2c7b684d8ddd0e8619b3b696023d75e3
ToppCell	facs-Thymus-Epithelium-3m\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY4 MGLL AQP7 CDC42EP1	1.11e-04	181	61	4	bce56e12ab93693c9c04fa6aad8f2e1dff0c4d45
ToppCell	droplet-Heart-nan-24m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY4 MGLL AMOTL2 AQP7	1.11e-04	181	61	4	859c40889ede2cbf374c4d2efbb72dc3bc6441f5
ToppCell	remission-Platelet\|remission / disease stage, cell group and cell class	MPP1 ABCC3 MGLL PTGS1	1.13e-04	182	61	4	65e2798aacd670cbc3a8c8e9d1a2f7768513bb70
ToppCell	10x5'-bone_marrow-Hematopoietic_Erythro-Mega-Megakaryocyte_early\|bone_marrow / Manually curated celltypes from each tissue	MPP1 ABCC3 MGLL PTGS1	1.15e-04	183	61	4	3cc9f3dc3bc4bde1d3408b0a6ba58e135a11036d
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Mesenchymal-Mes-Pericyte-Peri_L1-6_MUSTN1\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL4A3 ADCY4 LTBR CDC42EP1	1.15e-04	183	61	4	944f7458b9127356815f75c88bbf7015ebdc8ec1
ToppCell	5'-Adult-LymphNode-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADCY4 RADIL PLA1A FAM171B	1.15e-04	183	61	4	2d0d3b486498a7903fa9a1f48b189291da49c430
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC3 CYP21A2 GLYCTK AQP7	1.15e-04	183	61	4	85446581999cd66b171c4f69b7eb8b0bbbaa8617
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Mesenchymal-Mes-Pericyte\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL4A3 ADCY4 LTBR CDC42EP1	1.15e-04	183	61	4	cee6b821adff538078232689965d3e6c131e7d14
ToppCell	PBMC-Control-Hematopoietic-Platelet-Platelet-plt_3\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	MPP1 ABCC3 MGLL PTGS1	1.18e-04	184	61	4	a5d904dd030d9c21be0f8b9ec432025f90fb5b8e
ToppCell	10x3'2.3-week_17-19-Hematopoietic-MK-MK\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	ABCC3 MGLL PTGS1 ADCY6	1.18e-04	184	61	4	ba65e3972b2b8d825a2c1a9d03d092cc1afad073
ToppCell	3'_v3-lymph-node_spleen-Hematopoietic_Erythro-Mega-Megakaryocyte_early\|lymph-node_spleen / Manually curated celltypes from each tissue	MPP1 ABCC3 MGLL PTGS1	1.18e-04	184	61	4	10607d7d92edcbb92d992900086b90b307421cc3
ToppCell	PBMC-Control-Hematopoietic-Platelet-Platelet-plt_3\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MPP1 ABCC3 MGLL PTGS1	1.18e-04	184	61	4	7617a00b2ebd6c5c9386c39a7e8220fdbf8669ff
ToppCell	droplet-Fat-Mat-18m-Endothelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY4 MGLL AQP7 CDC42EP1	1.20e-04	185	61	4	d9be5853acdda7b1ac819cf50c7940d1d2362d15
ToppCell	facs-Heart-RV\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY4 MGLL AQP7 CDC42EP1	1.20e-04	185	61	4	7cf2b0db059605032bfae60cf1b93c4c62608f0c
ToppCell	Multiple_Sclerosis-Other-Platelet\|Multiple_Sclerosis / Disease, Lineage and Cell Type	MPP1 ABCC3 MGLL PTGS1	1.20e-04	185	61	4	2e480dde7ecb2f88ff005f86ef732a1cf0209d45
ToppCell	PBMC-Mild-Hematopoietic-Platelet-Platelet-plt_3\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	MPP1 ABCC3 MGLL PTGS1	1.20e-04	185	61	4	0a2c8ce92a257d0ec5bcc8efa22792d53752c665
ToppCell	PBMC-Control-Hematopoietic-Platelet-Platelet\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	MPP1 ABCC3 MGLL PTGS1	1.23e-04	186	61	4	3bf38c80d892a73391009b426dec8ae26a027351
ToppCell	PBMC-Control-Hematopoietic-Platelet\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	MPP1 ABCC3 MGLL PTGS1	1.23e-04	186	61	4	7496137cebc191aecd1e6ae7fa33118b128fbfe6
ToppCell	Megakaryocytic-erythropoietic-Megakaryo-cells-Platelet\|World / Lineage, cell class and subclass	MPP1 ABCC3 MGLL PTGS1	1.23e-04	186	61	4	27807334e7241c8a9aeaf6403f0fd0b001fbc0d1
ToppCell	PBMC-Mild-Hematopoietic-Platelet-Platelet-plt_3\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MPP1 ABCC3 MGLL PTGS1	1.23e-04	186	61	4	4a9b5b3a56229629161d5404db2b8dd76e10cf4b
ToppCell	PBMC-Control-Hematopoietic-Platelet\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MPP1 ABCC3 MGLL PTGS1	1.23e-04	186	61	4	9c2fd0bbc968c317a763f52e72fa7182c3c49850
ToppCell	PBMC-Control-Hematopoietic-Platelet-Platelet\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MPP1 ABCC3 MGLL PTGS1	1.23e-04	186	61	4	06281df5e9665ccc510279bf7e552845c63d5dab
ToppCell	droplet-Heart-nan-18m-Endothelial-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY4 XDH MGLL AQP7	1.23e-04	186	61	4	49ad01d216860a2bd4d63905a7064471b02f2b37
ToppCell	facs-SCAT-Fat-24m-Endothelial-endothelial_cell\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY4 MGLL AQP7 CDC42EP1	1.25e-04	187	61	4	43e35ec995afd8780893de42ac4ee466794991d7
ToppCell	LV-10._Endothelium_II\|World / Chamber and Cluster_Paper	ADCY4 PLA1A ZNF366 PTGS1	1.25e-04	187	61	4	7876dcb4800c2e54874df3d933efb79307a64a97
Computational	Liver genes - metabolism and xenobiotics.	ABCC3 SLC38A10 CELSR3 DPYSL4 XDH MGLL LTBR MME AQP7 CDC42EP1	3.68e-05	563	41	10	MODULE_23
Computational	Neighborhood of MT4	DPYSL4 SIK3 CRAT NEK9 AQP7 ECE2	3.17e-04	247	41	6	MORF_MT4
Drug	enprofylline	ADCY4 XDH PTGS1 ADCY6	2.41e-06	36	60	4	CID000001676
Drug	AC1Q5WMQ	MMEL1 MME	6.83e-06	2	60	2	CID000134383
Drug	bosentan	COL4A3 TRPM4 MME PTGS1 ECE2	8.86e-06	106	60	5	CID000104865
Drug	candoxatrilat	MMEL1 MME	2.05e-05	3	60	2	ctd:C060942
Drug	boroleucine	MMEL1 MME	2.05e-05	3	60	2	CID000127495
Drug	naphthalene-diisocyanate	ADCY4 AQP4 AQP7 ADCY6	2.17e-05	62	60	4	CID003033874
Drug	hydroxyrubicin	ABCC3 XDH MME	2.97e-05	23	60	3	CID000072398
Drug	trimetoquinol	ADCY4 XDH ADCY6	3.39e-05	24	60	3	CID000005581
Drug	manganese-ATP	ADCY4 CRAT ADCY6	3.84e-05	25	60	3	CID000124341
Drug	omapatrilat	MMEL1 MME	4.08e-05	4	60	2	ctd:C106266
Drug	mepyramine	ADCY4 CYP21A2 MME PTGS1 ADCY6	5.37e-05	154	60	5	CID000004992
Drug	motapizone	ADCY4 MME ADCY6	6.05e-05	29	60	3	CID000065819
Drug	AC1N2DGT	ADCY4 PTGS1 ADCY6	6.71e-05	30	60	3	CID004045015
Drug	Daeam	MMEL1 MME	6.79e-05	5	60	2	CID009570639
Drug	sakuranin	XDH PTGS1	6.79e-05	5	60	2	CID000073607
Drug	Pencina	MMEL1 MME	6.79e-05	5	60	2	CID000030729
Drug	NSC-692968	ADCY4 PDPR PTGS1 ADCY6	7.52e-05	85	60	4	CID000392472
Drug	methyl red	FARSA CDC42SE1 LTBR AMOTL2	7.87e-05	86	60	4	CID000010303
Drug	thiorphan	MMEL1 MME PTGS1 ECE2	8.61e-05	88	60	4	CID000003132
Drug	dithiobispropionimidate	MMEL1 MME	1.02e-04	6	60	2	CID000160557
Drug	fenbufen	CRAT PTGS1	1.02e-04	6	60	2	CID000003335
Drug	tienilic acid	ABCC3 ADCY4 CYP21A2 ADCY6	1.07e-04	93	60	4	CID000038409
Drug	1,3-DCG	ADCY4 MGLL PTGS1 ADCY6	1.11e-04	94	60	4	CID000150911
Drug	G-Faaf-4MN	MMEL1 MME	1.42e-04	7	60	2	CID005748219
Drug	RB 38A	MMEL1 MME	1.42e-04	7	60	2	CID000129130
Drug	Oi-1	ADAMTS3 ADAMTS2	1.42e-04	7	60	2	CID000448053
Drug	p-bromophenacyl bromide	PLA1A MGLL MME PTGS1	1.53e-04	102	60	4	CID000007454
Drug	Gabapentin [60142-96-3]; Up 200; 23.4uM; MCF7; HT_HG-U133A	ABCC3 MORN1 XDH AQP4 NEK9	1.56e-04	193	60	5	7229_UP
Drug	Lopac-S-1316	ADCY4 FBXL14 ADCY6	1.60e-04	40	60	3	CID003086457
Drug	Benfotiamine [22457-89-2]; Up 200; 8.6uM; PC3; HT_HG-U133A	DTX3 DPYSL4 XDH NEK9 CDC42EP1	1.63e-04	195	60	5	4312_UP
Drug	clofibrate	ABCC3 ADCY4 CYP21A2 XDH CRAT ADCY6	1.67e-04	311	60	6	CID000002796
Drug	Acacetin [480-44-4]; Up 200; 14uM; PC3; HT_HG-U133A	COL4A3 TGFBR1 ABCC3 NEK9 PTGS1	1.67e-04	196	60	5	4324_UP
Drug	Spironolactone [52-01-7]; Up 200; 9.6uM; PC3; HT_HG-U133A	ABCC3 CELSR3 MORN1 PLA1A DTX3	1.67e-04	196	60	5	5781_UP
Drug	AC1NIP3C	ADCY4 PTGS1 ADCY6	1.73e-04	41	60	3	CID004834553
Drug	Zimelidine dihydrochloride monohydrate [61129-30-4]; Down 200; 9.8uM; PC3; HT_HG-U133A	MPP1 FARSA ZNF324 NEK9 CASK	1.75e-04	198	60	5	4609_DN
Drug	Pirenperone [ 75444-65-4]; Up 200; 10.2uM; MCF7; HT_HG-U133A	MPP1 COL4A3 CRAT NEK9 CDC42EP1	1.75e-04	198	60	5	5639_UP
Drug	Viomycin sulfate [37883-00-4]; Up 200; 5.2uM; MCF7; HT_HG-U133A	TGFBR1 ABCC3 MORN1 PTGS1 CDC42EP1	1.79e-04	199	60	5	3541_UP
Drug	PF-00539758-00 [351321-34-1]; Down 200; 10uM; PC3; HT_HG-U133A	ABCC3 CELSR3 XDH NEK9 ADCY6	1.79e-04	199	60	5	6379_DN
Drug	Amidopyrine [58-15-1]; Up 200; 17.2uM; PC3; HT_HG-U133A	ABCC3 MORN1 AQP4 NEK9 PTGS1	1.84e-04	200	60	5	4481_UP
Drug	HCBP-Gly	MMEL1 MME	1.89e-04	8	60	2	CID000124786
Drug	Pglu-leu	MMEL1 MME	1.89e-04	8	60	2	CID000152417
Drug	AC1L524D	MMEL1 MME	1.89e-04	8	60	2	CID000196667
Drug	2-naphthyl laurate	XDH CRAT	1.89e-04	8	60	2	CID000080656
Drug	v 110	MMEL1 MME	1.89e-04	8	60	2	CID000198155
Drug	cFP-F-pAB	MMEL1 MME	1.89e-04	8	60	2	CID000132283
Drug	AC1L1EV8	ADCY4 ADCY6	1.89e-04	8	60	2	CID000002964
Drug	Saapna	MMEL1 MME	1.89e-04	8	60	2	CID005748178
Drug	Neurotensin (1-10)	MMEL1 MME	1.89e-04	8	60	2	CID003085266
Drug	lithium aluminum hydride	ADCY4 MMEL1 MME AQP4 AQP7 ADCY6	1.95e-04	320	60	6	CID000028112
Drug	1iiq	ADCY4 MME PTGS1 ADCY6	2.26e-04	113	60	4	CID000446293
Drug	AC1L1AL2	ADCY4 MGLL PTGS1 ADCY6	2.42e-04	115	60	4	CID000001035
Drug	14,15-dihydroforskolin	ADCY4 ADCY6	2.43e-04	9	60	2	CID000194193
Drug	AC1L4FY9	MMEL1 MME	2.43e-04	9	60	2	CID000156313
Drug	2,4-DPD	ADAMTS3 ADAMTS2	2.43e-04	9	60	2	CID000170509
Drug	mepirizole	CRAT PTGS1	2.43e-04	9	60	2	CID000003242
Drug	AC1L31NU	MMEL1 MME	2.43e-04	9	60	2	CID000132838
Drug	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	TGFBR1 CAND2 ADAMTS3 ADAMTS2 XDH DISP2 MBD5 PTGS1 CDC42EP1	2.47e-04	807	60	9	ctd:C548651
Disease	cerebral amyloid angiopathy (is_marker_for)	MME AQP4	2.43e-05	4	60	2	DOID:9246 (is_marker_for)
Disease	lethal congenital contracture syndrome (is_implicated_in)	NEK9 ADCY6	8.48e-05	7	60	2	DOID:0060558 (is_implicated_in)
Disease	ubiquitin-conjugating enzyme E2 G2 measurement	CYP21A2 MUC22	1.81e-04	10	60	2	EFO_0022035
Disease	cholesterol:total lipids ratio, low density lipoprotein cholesterol measurement	PDXDC1 CYP21A2 MACF1 SIK3	2.15e-04	144	60	4	EFO_0004611, EFO_0020943
Disease	cholesterol to total lipids in IDL percentage	PDXDC1 MACF1 SIK3	2.52e-04	60	60	3	EFO_0022233
Disease	body surface area	PDXDC1 EEF1AKMT4-ECE2 ADAMTS3 CYP21A2 MACF1 PRDM4 ECE2	3.21e-04	643	60	7	EFO_0022196
Disease	phospholipids:total lipids ratio, intermediate density lipoprotein measurement	CYP21A2 MACF1 SIK3	3.49e-04	67	60	3	EFO_0008595, EFO_0020946
Disease	free cholesterol to total lipids in large LDL percentage	PDXDC1 MACF1 SIK3	4.68e-04	74	60	3	EFO_0022280
Disease	visceral adipose tissue measurement, body mass index	ADAMTS2 RHBG SIK3	7.50e-04	87	60	3	EFO_0004340, EFO_0004765
Disease	brain age measurement	EEF1AKMT4-ECE2 ECE2	7.55e-04	20	60	2	EFO_0010602
Disease	kidney disease (biomarker_via_orthology)	TGFBR1 ABCC3	8.33e-04	21	60	2	DOID:557 (biomarker_via_orthology)
Disease	albuminuria	COL4A3 CYP21A2 AQP7	9.39e-04	94	60	3	EFO_0004285
Disease	cholesteryl esters:total lipids ratio, intermediate density lipoprotein measurement	CYP21A2 MACF1 SIK3	1.22e-03	103	60	3	EFO_0008595, EFO_0020944
Disease	hepatocellular carcinoma (biomarker_via_orthology)	ABCC3 XDH MME	1.40e-03	108	60	3	DOID:684 (biomarker_via_orthology)
Disease	Malignant neoplasm of breast	XIRP1 ZNF366 DTX3 XDH MACF1 MME SIK3 PTGS1	1.43e-03	1074	60	8	C0006142
Disease	heart conduction disease (implicated_via_orthology)	MMEL1 MME	1.94e-03	32	60	2	DOID:10273 (implicated_via_orthology)
Disease	cholesterol:total lipids ratio, intermediate density lipoprotein measurement	PDXDC1 CYP21A2 MACF1	1.94e-03	121	60	3	EFO_0008595, EFO_0020943

Protein segments in the cluster

Peptide	Gene	Start	Entry
FNEGLLTGGHRHQEM	AMOTL2	611	Q9Y2J4
GVTMVHGNLTAGHGL	AQP4	146	P55087
IHDRGHQGHRMGDGT	ERVPABLB-1	16	P60509
FVHLTHIGSGEMGAG	CDC42SE1	36	Q9NRR8
GHMGERVIGHKGERG	COL4A3	216	Q01955
LANHMEAGGRAGRIH	ADCY6	501	O43306
SGLAHLHMEIVGTQG	ACVR1C	301	Q8NER5
ANHMEAGGVPGRVHI	ADCY4	396	Q8NFM4
RSHVAGQMLHGGGSR	CRAT	301	P43155
GGLAQRVGRTMHHFG	DISP2	576	A7MBM2
GHVLGMEHDGQGNRC	ADAMTS2	411	O95450
LHVHGGEKVGIVGRT	ABCC3	1311	O15438
LGMGLIDGMHTHLGA	RADIL	986	Q96JH8
GEVSHGMREGHGFLV	MORN1	111	Q5T089
GGMIHRQGTLHVGDE	CASK	521	O14936
MQGGTKLHGQLGHGD	NEK9	396	Q8TD19
DHVGHGQSEGERMVV	MGLL	76	Q99685
HSLGNALVHGGELEM	MUC22	1721	E2RYF6
ALVHGGELEMGHGGT	MUC22	1726	E2RYF6
EGSGQLLEGHVHMAA	CYP21A2	271	P08686
GIGVVMGHELTHAFD	ECE2	641	P0DPD6
IHGHIIGMGLSPDNR	FBXW5	401	Q969U6
LFHGISGGHIQGIME	LHX9	21	Q9NQ69
PVGHIVHTGMLNEGG	PDPR	556	Q8NCN5
GEQGHMALLGHSLGA	PDXDC1	86	Q6P996
LVDGGQRGHMHNGLN	PCED1B	61	Q96HM7
GLDIQDEMGRHEVGH	ERGIC1	86	Q969X5
GGIGMVIGHEITHGF	MME	576	P08473
GVHVAGRISGAHMNA	AQP7	81	O14520
GRIGGGRNMDHHILH	PTGS1	431	P23219
GIGMVIGHEITHGFD	MMEL1	606	Q495T6
HLSDVGIGHLAGMTR	FBXL14	181	Q8N1E6
QVVDGGIIHHISGMR	MACF1	2506	Q9UPN3
HGLMVLPGGVDVHTR	DPYSL4	61	O14531
LALGGGGEHPEMHRA	DTX3	106	Q8N9I9
FGGIGVVMGHELTHA	EEF1AKMT4-ECE2	711	P0DPD8
GHVLGMEHDGQGNRC	ADAMTS3	401	O15072
LQGGAHLLHTGMTGT	GLYCTK	496	Q8IVS8
RHTMHVGRGGDVFGD	CDC42EP1	46	Q00587
HLIGLGTDTDMHGIV	HEPHL1	646	Q6MZM0
SAVIHGRNMGGVDHD	MBD5	1141	Q9P267
SSLGVMEGRQHGTLH	LTO1	31	Q8WV07
MEGRQHGTLHGAKIG	LTO1	36	Q8WV07
HGGMIHRQGSLHVGD	MPP1	101	Q00013
QEEPGGRRGHHVLMV	CELSR3	1856	Q9NYQ7
AISCMGHLVGHLGDR	CAND2	591	O75155
GQQGHRLDHGGHLEM	SLC38A10	971	Q9HBR0
RHILDGGSGVIMEHP	FAM171B	761	Q6P995
ADAVGHGGVIPMHGN	PRDM4	246	Q9UKN5
VMIHSGSRGLGHQVA	RTCB	256	Q9Y3I0
EHGGGMDSLTHAGQR	PPP1R12C	281	Q9BZL4
VVADHGLTLGHLMGV	FARSA	376	Q9Y285
SGGEIFDHLVAHGRM	SIK3	146	Q9Y2K2
SGLAHLHMEIVGTQG	TGFBR1	311	P36897
HIIGVSLGAHVGGMV	PLA1A	161	Q53H76
GPMQLSTVGHGDRDH	TULP4	781	Q9NRJ4
QDLEAAGGRGHHRMG	ZNF324	211	O75467
SGYVLLHHVMGGLEG	PYROXD2	261	Q8N2H3
LHHVMGGLEGMQGAW	PYROXD2	266	Q8N2H3
GGHIHVGVESMINAD	RHBG	116	Q9H310
LLTHGGTEMGQGLHT	XDH	1031	P47989
HSGEGHERGRGNSKM	nan	86	Q8IYB0
VAHGTNGIHVTGGSM	LTBR	341	P36941
HGVMERGLHSQGLGR	ZNF366	556	Q8N895
HHGGILMEARGPGEL	XIRP1	786	Q702N8
GIGRHVGVAVRDHQM	TRPM4	161	Q8TD43