Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transmembrane receptor protein tyrosine kinase activity	EPHB4 FLT4 EPHA2 NTRK3 INSRR EPHA4	5.05e-07	65	91	6	GO:0004714
GeneOntologyMolecularFunction	ephrin receptor activity	EPHB4 EPHA2 NTRK3 EPHA4	1.48e-06	19	91	4	GO:0005003
GeneOntologyMolecularFunction	transmembrane receptor protein kinase activity	EPHB4 FLT4 EPHA2 NTRK3 INSRR EPHA4	2.48e-06	85	91	6	GO:0019199
GeneOntologyMolecularFunction	protein tyrosine kinase activity	EPHB4 JAK1 FLT4 EPHA2 NTRK3 INSRR EPHA4	4.48e-06	145	91	7	GO:0004713
GeneOntologyMolecularFunction	protein kinase activity	EPHB4 JAK1 FLT4 CDC42BPA GUCY2F MTOR EPHA2 NTRK3 INSRR EPHA4	4.02e-04	600	91	10	GO:0004672
GeneOntologyMolecularFunction	nucleocytoplasmic carrier activity	TNPO2 TNPO3 XPO7	4.13e-04	32	91	3	GO:0140142
GeneOntologyMolecularFunction	GPI-linked ephrin receptor activity	NTRK3 EPHA4	4.25e-04	7	91	2	GO:0005004
GeneOntologyBiologicalProcess	pyrimidine nucleobase metabolic process	TYMS MTOR CDA RRM1	2.44e-06	22	91	4	GO:0006206
GeneOntologyBiologicalProcess	carbohydrate derivative metabolic process	ADAMTS12 TYMS CFH CROT GUCY2F MTOR ST6GALNAC3 EPHA2 CST2 CST4 DLAT PYGL CHPF2 CDA EXTL1 POGLUT2 RRM1 NAGPA	5.68e-06	1226	91	18	GO:1901135
GeneOntologyBiologicalProcess	iodide transport	MTOR SLC26A4 TG	1.34e-05	11	91	3	GO:0015705
GeneOntologyBiologicalProcess	nucleobase metabolic process	TYMS MTOR CDA RRM1	4.60e-05	45	91	4	GO:0009112
GeneOntologyBiologicalProcess	regulation of anatomical structure morphogenesis	ADAMTS12 EPHB4 JAK1 FLT4 CDX2 SYNE1 EPHA2 NTRK3 CST2 CST4 EMILIN2 MACF1 ALOX12 PLXNA2 EPHA4	7.97e-05	1090	91	15	GO:0022603
Domain	Pkinase_Tyr	EPHB4 JAK1 FLT4 GUCY2F EPHA2 NTRK3 INSRR EPHA4	1.84e-07	129	89	8	PF07714
Domain	Tyr_kinase_cat_dom	EPHB4 JAK1 FLT4 EPHA2 NTRK3 INSRR EPHA4	2.04e-07	88	89	7	IPR020635
Domain	TyrKc	EPHB4 JAK1 FLT4 EPHA2 NTRK3 INSRR EPHA4	2.04e-07	88	89	7	SM00219
Domain	Ser-Thr/Tyr_kinase_cat_dom	EPHB4 JAK1 FLT4 GUCY2F EPHA2 NTRK3 INSRR EPHA4	3.09e-07	138	89	8	IPR001245
Domain	PROTEIN_KINASE_TYR	EPHB4 JAK1 FLT4 EPHA2 NTRK3 INSRR EPHA4	3.98e-07	97	89	7	PS00109
Domain	Tyr_kinase_AS	EPHB4 JAK1 FLT4 EPHA2 NTRK3 INSRR EPHA4	3.98e-07	97	89	7	IPR008266
Domain	Ephrin_rec_like	EPHB4 EPHA2 EPHA4 TG	5.64e-06	25	89	4	SM01411
Domain	Tyr-kin_ephrin_A/B_rcpt-like	EPHB4 EPHA2 EPHA4 TG	5.64e-06	25	89	4	IPR011641
Domain	Kinase-like_dom	EPHB4 JAK1 FLT4 CDC42BPA GUCY2F MTOR EPHA2 NTRK3 INSRR MACF1 ACAD10 EPHA4	9.82e-06	542	89	12	IPR011009
Domain	RECEPTOR_TYR_KIN_V_2	EPHB4 EPHA2 EPHA4	3.67e-05	14	89	3	PS00791
Domain	RECEPTOR_TYR_KIN_V_1	EPHB4 EPHA2 EPHA4	3.67e-05	14	89	3	PS00790
Domain	Tyr_kinase_rcpt_V_CS	EPHB4 EPHA2 EPHA4	3.67e-05	14	89	3	IPR001426
Domain	EphA2_TM	EPHB4 EPHA2 EPHA4	3.67e-05	14	89	3	PF14575
Domain	Ephrin_rcpt_lig-bd_dom	EPHB4 EPHA2 EPHA4	3.67e-05	14	89	3	IPR001090
Domain	Eph_TM	EPHB4 EPHA2 EPHA4	3.67e-05	14	89	3	IPR027936
Domain	EPH_lbd	EPHB4 EPHA2 EPHA4	3.67e-05	14	89	3	SM00615
Domain	Ephrin_lbd	EPHB4 EPHA2 EPHA4	3.67e-05	14	89	3	PF01404
Domain	Tyr_kinase_ephrin_rcpt	EPHB4 EPHA2 EPHA4	3.67e-05	14	89	3	IPR016257
Domain	EPH_LBD	EPHB4 EPHA2 EPHA4	3.67e-05	14	89	3	PS51550
Domain	Spectrin	SPTBN5 SYNE1 MACF1	1.73e-04	23	89	3	PF00435
Domain	ACTININ_2	SPTBN5 SYNE1 MACF1	1.73e-04	23	89	3	PS00020
Domain	ACTININ_1	SPTBN5 SYNE1 MACF1	1.73e-04	23	89	3	PS00019
Domain	Actinin_actin-bd_CS	SPTBN5 SYNE1 MACF1	1.73e-04	23	89	3	IPR001589
Domain	EGF-like_CS	EPHB4 SELL EPHA2 C1R ASTN1 C9 NAGPA	2.49e-04	261	89	7	IPR013032
Domain	CH	SPTBN5 SYNE1 MACF1 SMTN	2.61e-04	65	89	4	SM00033
Domain	EGF_2	EPHB4 SELL EPHA2 C1R ASTN1 C9 NAGPA	2.74e-04	265	89	7	PS01186
Domain	CH	SPTBN5 SYNE1 MACF1 SMTN	3.47e-04	70	89	4	PF00307
Domain	Spectrin_repeat	SPTBN5 SYNE1 MACF1	3.49e-04	29	89	3	IPR002017
Domain	-	SPTBN5 SYNE1 MACF1 SMTN	3.67e-04	71	89	4	1.10.418.10
Domain	CH	SPTBN5 SYNE1 MACF1 SMTN	4.08e-04	73	89	4	PS50021
Domain	Semap_dom	SEMA6B SEMA5B PLXNA2	4.27e-04	31	89	3	IPR001627
Domain	SEMA	SEMA6B SEMA5B PLXNA2	4.27e-04	31	89	3	PS51004
Domain	Sema	SEMA6B SEMA5B PLXNA2	4.27e-04	31	89	3	SM00630
Domain	Sema	SEMA6B SEMA5B PLXNA2	4.27e-04	31	89	3	PF01403
Domain	Protein_kinase_ATP_BS	EPHB4 JAK1 FLT4 CDC42BPA EPHA2 NTRK3 INSRR EPHA4	4.51e-04	379	89	8	IPR017441
Domain	CH-domain	SPTBN5 SYNE1 MACF1 SMTN	4.52e-04	75	89	4	IPR001715
Domain	Plexin_repeat	SEMA6B SEMA5B PLXNA2	4.69e-04	32	89	3	IPR002165
Domain	SPEC	SPTBN5 SYNE1 MACF1	4.69e-04	32	89	3	SM00150
Domain	PSI	SEMA6B SEMA5B PLXNA2	4.69e-04	32	89	3	PF01437
Domain	Spectrin/alpha-actinin	SPTBN5 SYNE1 MACF1	4.69e-04	32	89	3	IPR018159
Domain	Prot_kinase_dom	EPHB4 JAK1 FLT4 CDC42BPA GUCY2F EPHA2 NTRK3 INSRR EPHA4	5.34e-04	489	89	9	IPR000719
Domain	PROTEIN_KINASE_DOM	EPHB4 JAK1 FLT4 CDC42BPA GUCY2F EPHA2 NTRK3 INSRR EPHA4	5.66e-04	493	89	9	PS50011
Domain	Prot_inh_cystat_CS	CST2 CST4	7.91e-04	9	89	2	IPR018073
Domain	MAC_perforin	ASTN1 C9	9.86e-04	10	89	2	IPR001862
Domain	Ephrin_rec_like	EPHB4 TG	1.20e-03	11	89	2	PF07699
Domain	Tyr_kinase_rcpt_2_CS	NTRK3 INSRR	1.20e-03	11	89	2	IPR002011
Domain	PSI	SEMA6B SEMA5B PLXNA2	1.20e-03	44	89	3	IPR016201
Domain	PSI	SEMA6B SEMA5B PLXNA2	1.37e-03	46	89	3	SM00423
Domain	MACPF	ASTN1 C9	1.44e-03	12	89	2	IPR020864
Domain	Cystatin	CST2 CST4	1.44e-03	12	89	2	IPR027214
Domain	CYSTATIN	CST2 CST4	1.44e-03	12	89	2	PS00287
Domain	MACPF	ASTN1 C9	1.44e-03	12	89	2	SM00457
Domain	RECEPTOR_TYR_KIN_II	NTRK3 INSRR	1.44e-03	12	89	2	PS00239
Domain	PROTEIN_KINASE_ATP	EPHB4 JAK1 FLT4 CDC42BPA EPHA2 NTRK3 INSRR EPHA4	1.55e-03	459	89	8	PS00107
Domain	FN3	EPHB4 EPHA2 INSRR ASTN1 EPHA4	1.92e-03	185	89	5	SM00060
Domain	Sushi	SELL CFH C1R	1.95e-03	52	89	3	PF00084
Domain	IMPORTIN_B_NT	TNPO2 XPO7	1.97e-03	14	89	2	PS50166
Domain	CCP	SELL CFH C1R	2.18e-03	54	89	3	SM00032
Domain	Beta/gamma_crystallin	CRYGC CRYGS	2.26e-03	15	89	2	IPR001064
Domain	CRYSTALLIN_BETA_GAMMA	CRYGC CRYGS	2.26e-03	15	89	2	PS50915
Domain	IBN_N	TNPO2 XPO7	2.26e-03	15	89	2	PF03810
Domain	Crystall	CRYGC CRYGS	2.26e-03	15	89	2	PF00030
Domain	XTALbg	CRYGC CRYGS	2.26e-03	15	89	2	SM00247
Domain	SUSHI	SELL CFH C1R	2.42e-03	56	89	3	PS50923
Domain	Sushi_SCR_CCP_dom	SELL CFH C1R	2.54e-03	57	89	3	IPR000436
Domain	IBN_N	TNPO2 XPO7	2.58e-03	16	89	2	SM00913
Domain	FN3	EPHB4 EPHA2 INSRR ASTN1 EPHA4	2.63e-03	199	89	5	PS50853
Domain	Importin-beta_N	TNPO2 XPO7	2.91e-03	17	89	2	IPR001494
Domain	CY	CST2 CST4	2.91e-03	17	89	2	SM00043
Domain	FN3_dom	EPHB4 EPHA2 INSRR ASTN1 EPHA4	3.24e-03	209	89	5	IPR003961
Domain	G_crystallin-rel	CRYGC CRYGS	3.27e-03	18	89	2	IPR011024
Domain	LH2	PKD1L3 ALOX12	3.27e-03	18	89	2	SM00308
Domain	Cystatin_dom	CST2 CST4	3.27e-03	18	89	2	IPR000010
Domain	Cystatin	CST2 CST4	3.27e-03	18	89	2	PF00031
Domain	TSP_1	ADAMTS12 SEMA5B C9	3.38e-03	63	89	3	PF00090
Domain	TSP1	ADAMTS12 SEMA5B C9	3.69e-03	65	89	3	SM00209
Domain	TSP1_rpt	ADAMTS12 SEMA5B C9	3.69e-03	65	89	3	IPR000884
Domain	TSP1	ADAMTS12 SEMA5B C9	3.69e-03	65	89	3	PS50092
Domain	Semaphorin	SEMA6B SEMA5B	4.03e-03	20	89	2	IPR027231
Domain	-	EPHB4 FLT4 EPHA2 NTRK3 INSRR ASTN1 POGLUT2 PLXNA2 EPHA4	4.30e-03	663	89	9	2.60.40.10
Domain	-	PKD1L3 ALOX12	4.45e-03	21	89	2	2.60.60.20
Domain	PLAT	PKD1L3 ALOX12	4.45e-03	21	89	2	PF01477
Domain	PLAT/LH2_dom	PKD1L3 ALOX12	4.45e-03	21	89	2	IPR001024
Domain	PLAT	PKD1L3 ALOX12	4.45e-03	21	89	2	PS50095
Pathway	KEGG_AXON_GUIDANCE	EPHB4 SEMA6B SEMA5B EPHA2 PLXNA2 EPHA4	3.30e-05	129	67	6	M5539
Pubmed	The protein tyrosine kinase family of the human genome.	EPHB4 JAK1 FLT4 EPHA2 NTRK3 INSRR EPHA4	2.53e-09	83	92	7	11114734
Pubmed	Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer.	FLT4 EPHA2 NTRK3 INSRR EPHA4	7.10e-08	40	92	5	30898150
Pubmed	Eph/ephrin profiling in human breast cancer reveals significant associations between expression level and clinical outcome.	EPHB4 EPHA2 EPHA4	1.78e-07	5	92	3	21935409
Pubmed	Induction of autophagy by cystatin C: a mechanism that protects murine primary cortical neurons and neuronal cell lines.	MTOR CST2 CST4	3.56e-07	6	92	3	20352108
Pubmed	Identification of tyrosine kinases expressed in the male mouse gubernaculum during development.	EPHB4 JAK1 EPHA2 EPHA4	5.56e-07	25	92	4	15254900
Pubmed	Degenerate PCR-based cloning method for Eph receptors and analysis of their expression in the developing murine central nervous system and vasculature.	EPHB4 EPHA2 EPHA4	1.49e-06	9	92	3	11403717
Pubmed	Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development.	EPHB4 FLT4 EPHA2	2.12e-06	10	92	3	10323857
Pubmed	Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature.	EPHB4 FLT4 EPHA2 EPHA4	4.75e-06	42	92	4	11439183
Pubmed	Ephrin Ligands and Eph Receptors Show Regionally Restricted Expression in the Developing Palate and Tongue.	EPHB4 EPHA2 EPHA4	6.38e-06	14	92	3	26941654
Pubmed	Phage display of a human antibody against Clostridium tetani toxin.	IGKV1-39 IGKV1D-39	6.92e-06	2	92	2	7926831
Pubmed	Evaluation of EphA2 and EphB4 as Targets for Image-Guided Colorectal Cancer Surgery.	EPHB4 EPHA2	6.92e-06	2	92	2	28165374
Pubmed	Identification of human complement Factor H as a ligand for L-selectin.	SELL CFH	6.92e-06	2	92	2	10377245
Pubmed	Digenic inheritance of mutations in EPHA2 and SLC26A4 in Pendred syndrome.	EPHA2 SLC26A4	6.92e-06	2	92	2	32165640
Pubmed	Retinoid signaling is essential for patterning the endoderm of the third and fourth pharyngeal arches.	EPHA2 EPHA4	6.92e-06	2	92	2	10725232
Pubmed	EphA2 mutation in lung squamous cell carcinoma promotes increased cell survival, cell invasion, focal adhesions, and mammalian target of rapamycin activation.	MTOR EPHA2	6.92e-06	2	92	2	20360610
Pubmed	A Novel Occulta-Type Spina Bifida Mediated by Murine Double Heterozygotes EphA2 and EphA4 Receptor Tyrosine Kinases.	EPHA2 EPHA4	6.92e-06	2	92	2	29312933
Pubmed	Eph-A2 and Eph-A4 expression in human benign and malignant thyroid lesions: an immunohistochemical study.	EPHA2 EPHA4	6.92e-06	2	92	2	21873938
Pubmed	TrkB-dependent EphrinA reverse signaling regulates callosal axon fasciculate growth downstream of Neurod2/6.	SEMA6B SEMA5B NTRK3 PLXNA2	7.50e-06	47	92	4	35462405
Pubmed	Disruption of segmental neural crest migration and ephrin expression in delta-1 null mice.	EPHB4 EPHA2 EPHA4	1.19e-05	17	92	3	12217323
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	KLHL29 USP31 UBR5 SYNE1 MACF1 CHPF2 PLXNA2 XPO7	1.30e-05	407	92	8	12693553
Pubmed	PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord.	SEMA6B FZD9 SEMA5B PLXNA2 EPHA4	1.54e-05	117	92	5	17145500
Pubmed	Expression of Ephs and ephrins in developing mouse inner ear.	EPHB4 EPHA2 EPHA4	1.68e-05	19	92	3	12684176
Pubmed	Multiple roles of EPH receptors and ephrins in neural development.	EPHB4 EPHA2 EPHA4	1.98e-05	20	92	3	11256076
Pubmed	Eph receptors and ephrins: effectors of morphogenesis.	EPHB4 EPHA2 EPHA4	1.98e-05	20	92	3	10207129
Pubmed	The ephrins and Eph receptors in neural development.	EPHB4 EPHA2 EPHA4	1.98e-05	20	92	3	9530499
Pubmed	The Eph family receptors and ligands.	EPHB4 EPHA2 EPHA4	1.98e-05	20	92	3	9576626
Pubmed	Immunoglobulin genes of the kappa light chain type from two human lymphoid cell lines are closely related.	IGKV1-39 IGKV1D-39	2.07e-05	3	92	2	6091049
Pubmed	Down-regulation of JAK1 by RNA interference inhibits growth of the lung cancer cell line A549 and interferes with the PI3K/mTOR pathway.	JAK1 MTOR	2.07e-05	3	92	2	21861134
Pubmed	Malignant hematopoietic cells induce an increased expression of VEGFR-1 and VEGFR-3 on bone marrow endothelial cells via AKT and mTOR signalling pathways.	FLT4 MTOR	2.07e-05	3	92	2	16959214
Pubmed	Expression of two novel eph-related receptor protein tyrosine kinases in mammary gland development and carcinogenesis.	EPHB4 EPHA2	2.07e-05	3	92	2	8152808
Pubmed	Differential expressions of the eph family of receptor tyrosine kinase genes (sek, elk, eck) in the developing nervous system of the mouse.	EPHA2 EPHA4	2.07e-05	3	92	2	7609620
Pubmed	Human salivary cystatin S. Cloning, sequence analysis, hybridization in situ and immunocytochemistry.	CST2 CST4	2.07e-05	3	92	2	1898352
Pubmed	Immunofluorescence localization of cystatins in human lacrimal gland and in the exorbital lacrimal gland of the rat.	CST2 CST4	2.07e-05	3	92	2	1471486
Pubmed	Pendrin is a novel in vivo downstream target gene of the TTF-1/Nkx-2.1 homeodomain transcription factor in differentiated thyroid cells.	SLC26A4 TG	2.07e-05	3	92	2	16260629
Pubmed	Functional Assessment of Lipoyltransferase-1 Deficiency in Cells, Mice, and Humans.	LIPT1 DLAT	2.07e-05	3	92	2	31042466
Pubmed	Suppression of EphB4 improves the inhibitory effect of mTOR shRNA on the biological behaviors of ovarian cancer cells by down-regulating Akt phosphorylation.	EPHB4 MTOR	2.07e-05	3	92	2	22684558
Pubmed	mRNA expression and clinical significance of ERCC1, BRCA1, RRM1, TYMS and TUBB3 in postoperative patients with non-small cell lung cancer.	TYMS RRM1	2.07e-05	3	92	2	23803067
Pubmed	A change in conformational dynamics underlies the activation of Eph receptor tyrosine kinases.	EPHA2 EPHA4	2.07e-05	3	92	2	16977320
Pubmed	Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers.	GUCY2F NTRK3	2.07e-05	3	92	2	16941478
Pubmed	ECK, a human EPH-related gene, maps to 1p36.1, a common region of alteration in human cancers.	EPHA2 EPHA4	2.07e-05	3	92	2	9119409
Pubmed	Identification of full-sized forms of salivary (S-type) cystatins (cystatin SN, cystatin SA, cystatin S, and two phosphorylated forms of cystatin S) in human whole saliva and determination of phosphorylation sites of cystatin S.	CST2 CST4	2.07e-05	3	92	2	1778989
Pubmed	Prognostic Significance of High EphA1-4 Expression Levels in Locally Advanced Gastric Cancer.	EPHA2 EPHA4	2.07e-05	3	92	2	29491103
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	TYMS EPHB4 JAK1 USP31 CDC42BPA UBR5 PLCXD1 SYNE1 MACF1 TMCO3	2.10e-05	719	92	10	35337019
Pubmed	Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee.	EPHB4 EPHA2 EPHA4	2.30e-05	21	92	3	9267020
Pubmed	Roles of Eph receptors and ephrins in segmental patterning.	EPHB4 EPHA2 EPHA4	2.30e-05	21	92	3	11128993
Pubmed	Eph receptors and ephrins demarcate cerebellar lobules before and during their formation.	EPHB4 EPHA2 EPHA4	2.30e-05	21	92	3	10495276
Pubmed	Developmental expression of Eph and ephrin family genes in mammalian small intestine.	EPHB4 EPHA2 EPHA4	2.30e-05	21	92	3	20112066
Pubmed	Ephrin-B2 governs morphogenesis of endolymphatic sac and duct epithelia in the mouse inner ear.	EPHB4 SLC26A4 EPHA4	2.30e-05	21	92	3	24583262
Pubmed	Eph receptors and ephrins: regulators of guidance and assembly.	EPHB4 EPHA2 EPHA4	2.30e-05	21	92	3	10730216
Pubmed	Short-chain 3-hydroxyacyl-coenzyme A dehydrogenase associates with a protein super-complex integrating multiple metabolic pathways.	CST2 CST4 DLAT PYGL ACAD10	2.75e-05	132	92	5	22496890
Pubmed	Promotion of proliferation in the developing cerebral cortex by EphA4 forward signaling.	EPHB4 EPHA2 EPHA4	3.05e-05	23	92	3	19542359
Pubmed	Eph receptors and their ephrin ligands are expressed in developing mouse pancreas.	EPHB4 EPHA2 EPHA4	3.48e-05	24	92	3	16446123
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	DNHD1 CDC42BPA SYNE1 MACF1 TNPO3 NKRF	3.83e-05	234	92	6	36243803
Pubmed	Differential regulation of alternate promoter regions in Sox17 during endodermal and vascular endothelial development.	EPHB4 FLT4 CDX2	3.95e-05	25	92	3	36046192
Pubmed	RNA expression of genes involved in cytarabine metabolism and transport predicts cytarabine response in acute myeloid leukemia.	CDA RRM1	4.14e-05	4	92	2	26083014
Pubmed	Pharmacogenetic variants in the DPYD, TYMS, CDA and MTHFR genes are clinically significant predictors of fluoropyrimidine toxicity.	TYMS CDA	4.14e-05	4	92	2	23736036
Pubmed	[Expression of Gemcitabine-resistance-related gene and polymorphism of ribonucleotide reductase M1 gene promoter in Gemcitabine-resistant A549/Gem and NCI-H460/Gem cell lines].	CDA RRM1	4.14e-05	4	92	2	20211060
Pubmed	Eph and ephrin expression in normal placental development and preeclampsia.	EPHB4 EPHA2	4.14e-05	4	92	2	15193868
Pubmed	A splice variant of human ephrin-A4 encodes a soluble molecule that is secreted by activated human B lymphocytes.	EPHA2 EPHA4	4.14e-05	4	92	2	10607706
Pubmed	Molecular cloning, chromosome mapping and characterization of a testis-specific cystatin-like cDNA, cystatin T.	CST2 CST4	4.14e-05	4	92	2	10713450
Pubmed	Cystatin 10, a novel chondrocyte-specific protein, may promote the last steps of the chondrocyte differentiation pathway.	CST2 CST4	4.14e-05	4	92	2	13679380
Pubmed	Retinal guanylyl cyclase isozyme 1 is the preferential in vivo target for constitutively active GCAP1 mutants causing congenital degeneration of photoreceptors.	GUCA1B GUCY2F	4.14e-05	4	92	2	22623665
Pubmed	The kinase homology domain of retinal guanylyl cyclases 1 and 2 specifies the affinity and cooperativity of interaction with guanylyl cyclase activating protein-2.	GUCA1B GUCY2F	4.14e-05	4	92	2	9698373
Pubmed	Rare Genetic Variants Associated With Development of Age-Related Macular Degeneration.	CFH C9	4.14e-05	4	92	2	26767664
Pubmed	Ribonucleotide reductase and thymidylate synthase or exogenous deoxyribonucleosides reduce DNA damage and senescence caused by C-MYC depletion.	TYMS RRM1	4.14e-05	4	92	2	23249808
Pubmed	Partially folded aggregation intermediates of human gammaD-, gammaC-, and gammaS-crystallin are recognized and bound by human alphaB-crystallin chaperone.	CRYGC CRYGS	4.14e-05	4	92	2	20621668
Pubmed	Guanylate cyclase-activating protein 2 contributes to phototransduction and light adaptation in mouse cone photoreceptors.	GUCA1B GUCY2F	4.14e-05	4	92	2	29549122
Pubmed	Identification of transcripts with enriched expression in the developing and adult pancreas.	TYMS CFH COL15A1 ST6GALNAC3 INSRR EMILIN2 APLP1 CDA RRM1	4.21e-05	624	92	9	18554416
Pubmed	Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.	CFH COL15A1 ANGPTL2 CST2 CST4 EMILIN2	5.29e-05	248	92	6	24006456
Pubmed	Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.	EPHB4 FLT4 EPHA2	5.59e-05	28	92	3	18593464
Pubmed	Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.	KLHL29 JAK1 FLT4 EPHA2 NTRK3 INSRR EPHA4	6.08e-05	372	92	7	22939624
Pubmed	Endogenous Cell Type-Specific Disrupted in Schizophrenia 1 Interactomes Reveal Protein Networks Associated With Neurodevelopmental Disorders.	JAK1 MPST CRYGC AIMP2 UBR5	6.11e-05	156	92	5	29961565
Pubmed	Noggin is required for correct guidance of dorsal root ganglion axons.	EPHB4 SEMA6B SEMA5B	6.23e-05	29	92	3	12435358
Pubmed	Cystatin C Deficiency Increases LPS-Induced Sepsis and NLRP3 Inflammasome Activation in Mice.	CST2 CST4	6.89e-05	5	92	2	34440840
Pubmed	Cystatin C influences the autoimmune but not inflammatory response to cartilage type II collagen leading to chronic arthritis development.	CST2 CST4	6.89e-05	5	92	2	21443774
Pubmed	Autophagy dysfunction and regulatory cystatin C in macrophage death of atherosclerosis.	CST2 CST4	6.89e-05	5	92	2	27079462
Pubmed	Semaphorin 5A inhibits synaptogenesis in early postnatal- and adult-born hippocampal dentate granule cells.	SEMA5B PLXNA2	6.89e-05	5	92	2	25313870
Pubmed	Cystatin C increases in cardiac injury: a role in extracellular matrix protein modulation.	CST2 CST4	6.89e-05	5	92	2	20489058
Pubmed	The crystallins: genes, proteins and diseases.	CRYGC CRYGS	6.89e-05	5	92	2	9426193
Pubmed	A receptor protein tyrosine kinase implicated in the segmental patterning of the hindbrain and mesoderm.	EPHA2 EPHA4	6.89e-05	5	92	2	1295734
Pubmed	IL-27 inhibits IFN-γ induced autophagy by concomitant induction of JAK/PI3 K/Akt/mTOR cascade and up-regulation of Mcl-1 in Mycobacterium tuberculosis H37Rv infected macrophages.	JAK1 MTOR	6.89e-05	5	92	2	25194337
Pubmed	Neuroprotection mediated by cystatin C-loaded extracellular vesicles.	CST2 CST4	6.89e-05	5	92	2	31367000
Pubmed	Mouse and rat cystatin C: Escherichia coli production, characterization and tissue distribution.	CST2 CST4	6.89e-05	5	92	2	8761177
Pubmed	Overexpression of human cystatin C in transgenic mice does not affect levels of endogenous brain amyloid Beta Peptide.	CST2 CST4	6.89e-05	5	92	2	14742906
Pubmed	Clinical significance of ephrin (eph)-A1, -A2, -a4, -a5 and -a7 receptors in pancreatic ductal adenocarcinoma.	EPHA2 EPHA4	6.89e-05	5	92	2	19949912
Pubmed	Deciphering the autophagy regulatory network via single-cell transcriptome analysis reveals a requirement for autophagy homeostasis in spermatogenesis.	CST2 CST4	6.89e-05	5	92	2	33754041
Pubmed	Functional Study and Mapping Sites for Interaction with the Target Enzyme in Retinal Degeneration 3 (RD3) Protein.	GUCA1B GUCY2F	6.89e-05	5	92	2	27471269
Pubmed	Carminerin contributes to chondrocyte calcification during endochondral ossification.	CST2 CST4	6.89e-05	5	92	2	16680148
Pubmed	Evolution of C, D and S-type cystatins in mammals: an extensive gene duplication in primates.	CST2 CST4	6.89e-05	5	92	2	25329717
Pubmed	Cystatin C deficiency promotes inflammation in angiotensin II-induced abdominal aortic aneurisms in atherosclerotic mice.	CST2 CST4	6.89e-05	5	92	2	20472891
Pubmed	Role of cystatin C in amyloid precursor protein-induced proliferation of neural stem/progenitor cells.	CST2 CST4	6.89e-05	5	92	2	23671283
Pubmed	Cystatin C stimulates the differentiation of mouse osteoblastic cells and bone formation.	CST2 CST4	6.89e-05	5	92	2	17592728
Pubmed	Obesity-Induced Increase in Cystatin C Alleviates Tissue Inflammation.	CST2 CST4	6.89e-05	5	92	2	32616516
Pubmed	Transforming growth factor beta regulates cystatin C in serum-free mouse embryo (SFME) cells.	CST2 CST4	6.89e-05	5	92	2	2241983
Pubmed	Strong conservation of the expression of cystatin C gene in choroid plexus.	CST2 CST4	6.89e-05	5	92	2	1636787
Pubmed	Enzymatic relay mechanism stimulates cyclic GMP synthesis in rod photoresponse: biochemical and physiological study in guanylyl cyclase activating protein 1 knockout mice.	GUCA1B GUCY2F	6.89e-05	5	92	2	23082185
Pubmed	Gene deletion of cystatin C aggravates brain damage following focal ischemia but mitigates the neuronal injury after global ischemia in the mouse.	CST2 CST4	6.89e-05	5	92	2	15450354
Pubmed	Decreased metastatic spread in mice homozygous for a null allele of the cystatin C protease inhibitor gene.	CST2 CST4	6.89e-05	5	92	2	10748866
Pubmed	Absence of the protease inhibitor cystatin C in inflammatory cells results in larger plaque area in plaque regression of apoE-deficient mice.	CST2 CST4	6.89e-05	5	92	2	15823274
Pubmed	Cystatin C deficiency promotes epidermal dysplasia in K14-HPV16 transgenic mice.	CST2 CST4	6.89e-05	5	92	2	21085595
Interaction	RP2 interactions	DMXL2 LIPT1 MTOR TNPO2 TNPO3 TBL3 XPO7	2.08e-07	95	89	7	int:RP2
Interaction	HCST interactions	JAK1 DMXL2 INTS2 MTOR TNPO2 ACAD10 TNPO3 XPO7	3.49e-06	205	89	8	int:HCST
Interaction	VSIG2 interactions	MTOR TNPO2 TNPO3 XPO7	1.16e-05	32	89	4	int:VSIG2
Interaction	FAM234A interactions	INTS2 MTOR TNPO2 TNPO3 PLXNA2 XPO7	2.02e-05	126	89	6	int:FAM234A
Interaction	CD80 interactions	INTS2 MTOR TNPO2 TNPO3 XPO7	2.61e-05	79	89	5	int:CD80
Interaction	MAS1 interactions	JAK1 FLT4 EPHA2 ACAD10 XPO7	3.94e-05	86	89	5	int:MAS1
Interaction	GPR45 interactions	JAK1 DMXL2 INTS2 MTOR TNPO2 ACAD10 TNPO3 XPO7	5.46e-05	300	89	8	int:GPR45
Interaction	HSPA1B interactions	EPHB4 FLT4 AIMP2 EPHA2 NTRK3 INSRR TRIM6 EPHA4	5.59e-05	301	89	8	int:HSPA1B
Interaction	SCN2B interactions	INTS2 MTOR TNPO2 TNPO3 XPO7	6.36e-05	95	89	5	int:SCN2B
Interaction	CMKLR1 interactions	JAK1 INTS2 MTOR CST2 CST4	8.51e-05	101	89	5	int:CMKLR1
Interaction	EFNA4 interactions	DMXL2 INTS2 TNPO2 EPHA2 TNPO3 EPHA4 XPO7	9.12e-05	239	89	7	int:EFNA4
Interaction	P2RY10 interactions	JAK1 INTS2 TNPO2 ACAD10 TNPO3	1.07e-04	106	89	5	int:P2RY10
Interaction	B3GNT8 interactions	INTS2 TNPO3 XPO7	1.21e-04	22	89	3	int:B3GNT8
GeneFamily	Fibronectin type III domain containing\|Sterile alpha motif domain containing\|EPH receptors	EPHB4 EPHA2 EPHA4	1.57e-05	14	65	3	1095
GeneFamily	Fibronectin type III domain containing	EPHB4 EPHA2 INSRR ASTN1 EPHA4	2.74e-04	160	65	5	555
GeneFamily	Complement system\|Sushi domain containing	CFH C1R C9	2.91e-04	36	65	3	492
GeneFamily	Receptor Tyrosine Kinases\|CD molecules	FLT4 NTRK3 INSRR	3.98e-04	40	65	3	321
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	SELL CFH C1R	1.13e-03	57	65	3	1179
GeneFamily	Beta-gamma crystallins	CRYGC CRYGS	1.30e-03	15	65	2	1359
GeneFamily	Cystatins, type 2	CST2 CST4	1.48e-03	16	65	2	965
GeneFamily	Armadillo repeat containing\|Importins	TNPO2 TNPO3	1.88e-03	18	65	2	596
GeneFamily	Immunoglobulin like domain containing\|Semaphorins	SEMA6B SEMA5B	2.32e-03	20	65	2	736
GeneFamily	G-patch domain containing\|Minor histocompatibility antigens	TFIP11 NKRF	2.81e-03	22	65	2	579
GeneFamily	Sterile alpha motif domain containing	EPHB4 EPHA2 EPHA4	3.91e-03	88	65	3	760
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	SELL PKD1L3	9.54e-03	41	65	2	1298
ToppCell	facs-Skin-nan-24m-Epithelial-inner_bulge\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS12 KLHL29 CRYGC ANGPTL2 NTRK3 PLXNA2	8.47e-07	155	92	6	fa2776d258e0420b2895de1008e292ad7725dac0
ToppCell	343B-Fibroblasts-Fibroblast-H-\|343B / Donor, Lineage, Cell class and subclass (all cells)	ADAMTS12 COL15A1 ANGPTL2 C22orf31 ASTN1 NKRF	1.66e-06	174	92	6	2627c3983009839fedbc5e3f628739dc026447f4
ToppCell	343B-Fibroblasts-Fibroblast-H\|343B / Donor, Lineage, Cell class and subclass (all cells)	ADAMTS12 COL15A1 ANGPTL2 C22orf31 ASTN1 NKRF	1.66e-06	174	92	6	507a33e58f62e2b72f0bcc743e84dbd0bf705a15
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	KLHL29 CFH ANGPTL2 NTRK3 C1R ASTN1	2.94e-06	192	92	6	8d56e360ebc624ca4cd7f0af4f3cc599c244f134
ToppCell	nucseq-Mesenchymal-Myocytic-Myocytic_2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ADAMTS12 CFH COL15A1 NTRK3 CST4 C1R	3.03e-06	193	92	6	5de87fc94a6e58899ef4124cf4887ed3ff96163a
ToppCell	RV-09._Endothelium_I\|RV / Chamber and Cluster_Paper	EPHB4 FLT4 ST6GALNAC3 SYNE1 PLXNA2 EPHA4	3.12e-06	194	92	6	7b408096e717f2327c12aea35a8d5fc4621d3b06
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	EPHB4 SEMA6B FLT4 COL15A1 SEMA5B ST6GALNAC3	3.31e-06	196	92	6	ab7be3858deabbd1fc44e8b9da8ff49a50bf1fb1
ToppCell	distal-Endothelial-Lymphatic-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FZD9 FLT4 ANGPTL2 ST6GALNAC3 SLC26A4 SMTN	3.40e-06	197	92	6	8f2e19409ebe9a490d5a245fa82c765ed6d77c3e
ToppCell	distal-1-mesenchymal-Myofibroblast\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CFH COL15A1 ANGPTL2 CST2 C1R EXTL1	3.61e-06	199	92	6	58c36f5a30c6862b7f5587a0b9bc31da99e43dd5
ToppCell	distal-mesenchymal-Myofibroblast-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CFH COL15A1 ANGPTL2 CST2 C1R EXTL1	3.61e-06	199	92	6	79917b5225cb45b4a0ea937f79f1752346e4346e
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FZD9 SYNE1 NTRK3 ASTN1 EXTL1 ANKRD55	3.61e-06	199	92	6	19a97e27a4758e794ce7246d295e112b47931a48
ToppCell	distal-3-mesenchymal-Myofibroblast\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CFH COL15A1 ANGPTL2 CST2 C1R MEIS3	3.61e-06	199	92	6	1f20addc0d138fec02ed6ca4c518169c568de263
ToppCell	distal-mesenchymal-Myofibroblast-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CFH COL15A1 ANGPTL2 CST2 C1R MEIS3	3.71e-06	200	92	6	069c8949b33ecfdb6da32992002d4060ff6082bc
ToppCell	367C-Fibroblasts-Fibroblast-B_(Myofibroblast)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	ADAMTS12 CFH COL15A1 ANGPTL2 CST2 C1R	3.71e-06	200	92	6	082e718c1da3f4fdd33a001d15ad3ddb2be985c7
ToppCell	367C-Fibroblasts-Fibroblast-B_(Myofibroblast)\|367C / Donor, Lineage, Cell class and subclass (all cells)	ADAMTS12 CFH COL15A1 ANGPTL2 CST2 C1R	3.71e-06	200	92	6	731e55070a7ff315091855bd88cda30e5a7e1a98
ToppCell	severe_COVID-19-NK_CD56bright\|World / disease group, cell group and cell class (v2)	CROT ZSWIM3 DLAT POGLUT2 EPHA4	1.60e-05	152	92	5	ab5a4e47b23d16018642d4c9c7f41b30205edf73
ToppCell	10x5'-Lung-Myeloid_Monocytic-Cycling_mono\|Lung / Manually curated celltypes from each tissue	TYMS SPTBN5 USP31 HJURP SMTN	1.81e-05	156	92	5	63b8cf14361b282872bc1c5b65d9fbc83e81a089
ToppCell	Adult-Mesenchymal-vascular_smooth_muscle_cell-D122\|Adult / Lineage, Cell type, age group and donor	ADAMTS12 COL15A1 SEMA5B NTRK3 SMTN	2.05e-05	160	92	5	fd14dfeb7021a4b7299371854dc8fc1fd66c8dae
ToppCell	facs-Marrow-Granulocytes-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA6B TECPR2 PLCXD1 TNPO2 HEPHL1	2.05e-05	160	92	5	56e6f4b82b5dc41c45f9d253c2db314a6f702b84
ToppCell	facs-Marrow-Granulocytes-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA6B TECPR2 PLCXD1 TNPO2 HEPHL1	2.05e-05	160	92	5	bb1b966fb9e801db15e67d03e49db4609d6f935a
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TYMS EPHB4 SEMA6B MTOR RRM1	2.11e-05	161	92	5	f4f5d6eaa32169de699c8ff8e8ae35179c8e25c0
ToppCell	367C-Lymphocytic-ILC-ILC-3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CARMIL2 TECPR2 CDA TMCO3 EPHA4	2.11e-05	161	92	5	8de421c61f4d5a6e05fdb20e4d230e2db98ee4d5
ToppCell	droplet-Lung-nan-18m-Lymphocytic-plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GUCA1B PLCXD1 PKD1L3 ANKRD55 TG	2.24e-05	163	92	5	5efecdd8a069a822bc9d35b407092925a865e629
ToppCell	droplet-Lung-nan-18m-Lymphocytic-Plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GUCA1B PLCXD1 PKD1L3 ANKRD55 TG	2.24e-05	163	92	5	0d94a427f86e62aba12c397c6d7b8cd297f3a0e5
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-plasma_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GUCA1B PLCXD1 PKD1L3 ANKRD55 TG	2.30e-05	164	92	5	b92e7c91910d518627376166c6ea9ed333b3d07e
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-plasma_cell-plasma_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GUCA1B PLCXD1 PKD1L3 ANKRD55 TG	2.30e-05	164	92	5	a1e43c6b3e2553f5604100db6e92bf244b70c36d
ToppCell	droplet-Heart-nan-18m-Mesenchymal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLHL29 CFH COL15A1 PLCXD1 HJURP	2.44e-05	166	92	5	9adceb746e67e955fd8b3e0984f4eed44b64a270
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-4\|TCGA-Lung / Sample_Type by Project: Shred V9	ADAMTS12 SEMA6B COL15A1 ANGPTL2 C1R	2.59e-05	168	92	5	aefea14b8b1c1b6a05f827effd22ba15274fddc9
ToppCell	facs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l15\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADAMTS12 CRYGC CDX2 COL15A1 ANGPTL2	2.59e-05	168	92	5	a8958b94ffc3423d56c250796dd253884b46f9d9
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FLT4 SEMA5B ST6GALNAC3 SYNE1 EPHA4	2.66e-05	169	92	5	987ff79ad563825dd9877ea8ccb536758f8c6700
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid-myeloid_monocytic-non-classical_monocyte\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DMXL2 CST2 EMILIN2 PYGL CDA	2.90e-05	172	92	5	968d18ab8c3cdeb7936a2aa721a7f41525763863
ToppCell	343B-Fibroblasts-Fibroblast-H\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	USP31 C22orf31 ASTN1 ACAD10 NKRF	2.90e-05	172	92	5	eb199c279fe8a2551121db37e9556893197d33ff
ToppCell	343B-Fibroblasts-Fibroblast-H-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	USP31 C22orf31 ASTN1 ACAD10 NKRF	2.90e-05	172	92	5	709c6b77a7a52b873eefb6caca28a41291d384af
ToppCell	TCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Non-keratinizing_Cervical_Squamous_Cell_Carcinoma-3\|TCGA-Cervix / Sample_Type by Project: Shred V9	USP31 CROT EPHA2 ALOX12 PLXNA2	3.14e-05	175	92	5	0cc215109d9915af47e4d0a120ce2e46910715fa
ToppCell	COVID-19-kidney-PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	USP31 FLT4 SEMA5B ST6GALNAC3 MACF1	3.60e-05	180	92	5	493cf8d1a8f2a1ed2672f394a0338b110fd81d88
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 CFH COL15A1 C1R MEIS3	3.69e-05	181	92	5	c6d2a13df3b74fade3b0c71e285b4c14c8e52413
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 CFH COL15A1 C1R MEIS3	3.69e-05	181	92	5	c62b0a2422377ffadaab63edd538e87a06fa5017
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SELL SEMA6B DMXL2 EMILIN2 CDA	3.79e-05	182	92	5	c3eafdc11858566aa7692b2f5dbe72ac01fb769a
ToppCell	NS-moderate-d_16-33-Lymphoid-NK\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ADAMTS12 COL15A1 NTRK3 C1R MEIS3	3.79e-05	182	92	5	fb503f8ecd013f1f2161a5841572b57cfcddb6fa
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SEMA6B FLT4 COL15A1 ST6GALNAC3 PLXNA2	3.89e-05	183	92	5	dc19857b66dcadbf7c87de91f7b1f4e8ef2857ed
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SEMA6B FLT4 COL15A1 ST6GALNAC3 PLXNA2	3.89e-05	183	92	5	4759560e5b4f4e5a00e5f933e3451a27c7c4aefe
ToppCell	wk_08-11-Hematologic_Lymphocytic-B-Immature_B\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	IGKV1-39 SELL IGKV1D-39 SIT1 GCSAM	3.99e-05	184	92	5	e6669a1b7ea7e4f8e094add5117689470019d85d
ToppCell	wk_20-22-Epithelial-PNS-intermediate_Schwann\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	COL15A1 PLCXD1 NTRK3 PYGL NKRF	3.99e-05	184	92	5	4e3ba64692868563a579902aa9c6f88cab5bce26
ToppCell	facs-Mammary_Gland-Mammary_Gland-3m-Mesenchymal-stromal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS12 CFH COL15A1 ANGPTL2 EMILIN2	4.10e-05	185	92	5	3cd0686a14e734a0f243070ab939adcb4c454478
ToppCell	facs-Mammary_Gland-Mammary_Gland-3m-Mesenchymal-stromal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS12 CFH COL15A1 ANGPTL2 EMILIN2	4.10e-05	185	92	5	00258f458cbf6d36449db95528a6b5038d731d2d
ToppCell	facs-Mammary_Gland-Mammary_Gland-3m-Mesenchymal\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS12 CFH COL15A1 ANGPTL2 EMILIN2	4.10e-05	185	92	5	a94694e226856bc5b168464f52d76004145717a5
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADAMTS12 COL15A1 ANGPTL2 C1R MEIS3	4.10e-05	185	92	5	87c416d14ca6255bee39b16e7571553e36ee3069
ToppCell	droplet-Heart-4Chambers-21m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT4 EPHA2 HJURP CDA ACAD10	4.10e-05	185	92	5	bb5a4cf93534b9bcd0923f314c389d571e91e7f8
ToppCell	PCW_07-8.5-Endothelial-Endothelial_immature-endo_immature_arterial2_(6)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CFH SEMA6B FLT4 COL15A1 PRSS51	4.31e-05	187	92	5	29b2e2be26a9d72b154760e47acf61cfe2f45fa7
ToppCell	Pericytes-HP_01\|World / lung cells shred on cell class, cell subclass, sample id	ADAMTS12 COL15A1 SEMA5B NTRK3 SMTN	4.31e-05	187	92	5	35f25780d113f60bf4c13749013c09612ee4ff41
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(CH25H+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CFH COL15A1 GUCY2F C22orf31 NTRK3	4.31e-05	187	92	5	39756ab418267151d86f9c2553db859f71900bb1
ToppCell	Smart-seq2-bone_marrow_(Smart-seq2)\|Smart-seq2 / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CDC42BPA SYNE1 HJURP ZRANB2 PYGL	4.42e-05	188	92	5	557a0ac069a6ff4e687cac032f64170b9b247165
ToppCell	3'_v3-GI_small-bowel-Myeloid_Monocytic-Classical_monocytes\|GI_small-bowel / Manually curated celltypes from each tissue	SELL DMXL2 EMILIN2 PYGL CDA	4.54e-05	189	92	5	74a5e61cd820f2495dde40e766c771a31d8c4e7d
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	EPHB4 SEMA6B SEMA5B ST6GALNAC3 CDA	4.65e-05	190	92	5	656483751e4bf137e4e4bfb2a03a478a8f7fcb63
ToppCell	facs-Lung-3m-Endothelial-lymphatic_endothelial\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EPHB4 SEMA6B FLT4 HJURP SMTN	4.65e-05	190	92	5	a1514d2186eb4fe569971ab22dc0c17d353fb94a
ToppCell	facs-Lung-3m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EPHB4 SEMA6B FLT4 HJURP SMTN	4.65e-05	190	92	5	0bb954a94317cfc742b9b6221bb80f8baa6d3ff1
ToppCell	facs-Lung-3m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EPHB4 SEMA6B FLT4 HJURP SMTN	4.65e-05	190	92	5	26e2237f65cb43723c5da853831b40df2982d6e4
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell-NK_CD56bright\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SELL JAK1 SYNE1 MACF1 EPHA4	4.77e-05	191	92	5	f1935e8f8467a2bc30588b7f2cc3b94e9c83b268
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell-NK_CD56bright-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SELL JAK1 SYNE1 MACF1 EPHA4	4.77e-05	191	92	5	1161e465c50c2071764279e01cf08b1048cce0e3
ToppCell	PCW_05-06-Endothelial-Endothelial_immature-endo_immature_arterial2_(6)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	SPTBN5 SEMA6B FLT4 COL15A1 PRSS51	4.77e-05	191	92	5	e3fc5c92491b6e334abffbf085c00a0b5fa1aed2
ToppCell	facs-Lung-3m-Mesenchymal-myofibroblast\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ANGPTL2 NTRK3 MEIS3 TCAP SMTN	4.77e-05	191	92	5	fd8331c7abdd999f55ba43d307945c6abfccbf84
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_chondroblast_(18)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	CFH FZD9 COL15A1 PYGL EXTL1	4.77e-05	191	92	5	273c4a757292a9301de0eaeacdec91c9866be229
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell-NK_CD56bright-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SELL JAK1 SYNE1 MACF1 EPHA4	4.77e-05	191	92	5	7a4fe96989f72159385270c712342ba3e1ca6fc3
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADAMTS12 CFH COL15A1 ANGPTL2 C1R	4.77e-05	191	92	5	0fae1c2ef9f83ac7721d0a9d69455bf97eed9257
ToppCell	Control-Lymphoid_T/NK-NK_CD56bright\|Control / Disease group, lineage and cell class	SELL JAK1 SYNE1 MACF1 EPHA4	4.77e-05	191	92	5	e842f29bc03ed6734b2a7b975e7830a498f2743c
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell-NK_CD56bright\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	SELL JAK1 SYNE1 MACF1 EPHA4	4.77e-05	191	92	5	c023ca893ceae19b54967096f6e2588dc39fa268
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_chondroblast_(18)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	CFH FZD9 COL15A1 PYGL EXTL1	4.77e-05	191	92	5	f9a46956778a8773d6656340ecf5d218376d79c2
ToppCell	3'-Distal_airway-Endothelial-Lymphatic_EC\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EPHB4 FZD9 FLT4 ANGPTL2 ST6GALNAC3	4.89e-05	192	92	5	2ec132a1740e865e7cc0f82ffd4772d43f7ac086
ToppCell	3'-Distal_airway-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_mature\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EPHB4 FZD9 FLT4 ANGPTL2 ST6GALNAC3	4.89e-05	192	92	5	3792c53b5d4b759573e1c7bb89ef9b654c9cbfcd
ToppCell	3'-Distal_airway-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EPHB4 FZD9 FLT4 ANGPTL2 ST6GALNAC3	4.89e-05	192	92	5	64022a47dccd7966777f6741d1c68e298f37ca9d
ToppCell	3'-Distal_airway-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_mature-Lymphatic_EC_mature_L.2.5.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EPHB4 FZD9 FLT4 ANGPTL2 ST6GALNAC3	4.89e-05	192	92	5	f67a88bd039944d3d7a5a4a9f2e053985075155c
ToppCell	11.5-Airway-Mesenchymal-Cartilage\|Airway / Age, Tissue, Lineage and Cell class	CFH FZD9 COL15A1 PYGL EXTL1	5.01e-05	193	92	5	d4779d92a4dd4b8b656383e6f4fce76d3bd70931
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADAMTS12 CFH ANGPTL2 C1R MEIS3	5.01e-05	193	92	5	b05361ffe111a38cfa26eb86e4ae62c15ac99b7b
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar-Macro_c6-VCAN\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	SEMA6B CDC42BPA EMILIN2 PYGL CDA	5.01e-05	193	92	5	52f5b0fbb8ca706206c65e7edbb1ddbd380aebae
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADAMTS12 ANGPTL2 SEMA5B NTRK3 SMTN	5.01e-05	193	92	5	800b0f5705fefcd3608e37801afae8a94474723e
ToppCell	wk_20-22-Hematologic_Lymphocytic-T_&_ILC-Cycling_T\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	TYMS SELL HJURP INSRR RRM1	5.01e-05	193	92	5	81e6240cffb094b2aa3684fd0889b6497f47c4f0
ToppCell	RV-09._Endothelium_I\|World / Chamber and Cluster_Paper	EPHB4 FLT4 ST6GALNAC3 SYNE1 PLXNA2	5.01e-05	193	92	5	e3fa47e2c7cd8a5b69186711c57751f2296de8ae
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	EPHB4 FLT4 ANGPTL2 SEMA5B ST6GALNAC3	5.14e-05	194	92	5	cf9cf115dbbb9997f7c303ae07f42f3d80ff9a21
ToppCell	Megakaryocytic-erythropoietic-Erythro-cells-Basophilic_Erythroblast\|World / Lineage, cell class and subclass	TYMS CFH MPST CDC42BPA POGLUT2	5.14e-05	194	92	5	f054d78429364622d402ce1d9bf6ad13a1a1bf7e
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFH ANGPTL2 CST2 C1R SMTN	5.14e-05	194	92	5	8fae8061b350336299aa81f378e07deadbd55123
ToppCell	Control-Myeloid-cMonocyte\|World / Disease state, Lineage and Cell class	SELL SEMA6B ST6GALNAC3 EMILIN2 CDA	5.14e-05	194	92	5	f852f5258617a66a4fbd56d64c7b47272e7b8b60
ToppCell	medial-Hematologic-Plasmacytoid_Dendritic\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SELL CDX2 CARMIL2 SIT1 ALOX12	5.14e-05	194	92	5	bb36274d6fe2d18c545a17d3809f331586502d01
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 CFH COL15A1 NTRK3 C1R	5.14e-05	194	92	5	c49f72441b3557e2c3a9c4239e68c0cf0652814b
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic-lymphocyte-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	TYMS CROT UBR5 HJURP RRM1	5.14e-05	194	92	5	8f4b63b0b9a40765205e4ca6bd94a675a83dbe3d
ToppCell	medial-2-Hematologic-Plasmacytoid_Dendritic\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SELL CDX2 CARMIL2 SIT1 ALOX12	5.14e-05	194	92	5	d58be6454a0795d6771036a1620553a153861615
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFH ANGPTL2 CST2 C1R SMTN	5.14e-05	194	92	5	4d7d24390fdb379f943ddcc70a63f23955e10163
ToppCell	medial-Hematologic-Plasmacytoid_Dendritic-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SELL CDX2 CARMIL2 SIT1 ALOX12	5.14e-05	194	92	5	0117cd68750153fd6b8978c8b4ce3589486d2b5f
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	EPHB4 SEMA6B FLT4 ST6GALNAC3 CDA	5.14e-05	194	92	5	fa6d51f36a3dae8763a595c20892987ed454c0f0
ToppCell	LA-09._Endothelium_I\|World / Chamber and Cluster_Paper	EPHB4 FLT4 ST6GALNAC3 SYNE1 PLXNA2	5.26e-05	195	92	5	fc95457a298b5d0dab687d9ee7e225a7f7b9a0d4
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADAMTS12 ANGPTL2 SEMA5B NTRK3 SMTN	5.26e-05	195	92	5	c51b1bee79e77aa2ac444a4883ef533c0095eaad
ToppCell	LV-09._Endothelium_I\|World / Chamber and Cluster_Paper	EPHB4 ST6GALNAC3 SYNE1 PLXNA2 EPHA4	5.26e-05	195	92	5	19e0a6c3eae1615aaa39767300acd937dfcb2a7f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 CFH COL15A1 NTRK3 C1R	5.26e-05	195	92	5	edd4cd8402af81737b2074f9dce71cc6ab09be7e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 CFH COL15A1 NTRK3 C1R	5.26e-05	195	92	5	3c3703f092b6fc1b7333426fb5e2823bfb74bb57
ToppCell	Tracheal-NucSeq-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ADAMTS12 FZD9 FLT4 ST6GALNAC3 PKD1L3	5.39e-05	196	92	5	09a7edf4a7defb7fe70d9777dd9500ee8421ff31
ToppCell	Tracheal-NucSeq-Endothelial-Endothelia_lymphatic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ADAMTS12 FZD9 FLT4 ST6GALNAC3 PKD1L3	5.39e-05	196	92	5	e50d2c66d5c5cd25fdfecdcc4c8506a1d0a85755
ToppCell	facs-Skin-Telogen-3m-Epithelial-bulge_keratinocyte\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLHL29 ANGPTL2 MACF1 PYGL PLXNA2	5.39e-05	196	92	5	90edf61116ffcb4f8b6be3d0a05732d59b0a87d5
ToppCell	IPF-Stromal-Myofibroblast\|World / Disease state, Lineage and Cell class	ADAMTS12 CFH COL15A1 ANGPTL2 C1R	5.39e-05	196	92	5	7fc9894ceb79dab9f0495acc84e2d6d0d1c69bb7
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	EPHB4 SEMA6B FLT4 ST6GALNAC3 SYNE1	5.39e-05	196	92	5	8f2031b1a9232c389517fbf3c29f47f9468b0077
ToppCell	facs-Skin-Telogen-3m-Epithelial-outer_bulge\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLHL29 ANGPTL2 MACF1 PYGL PLXNA2	5.39e-05	196	92	5	c936014125b2ed5f796221b74acb77b8f8359875
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	EPHB4 SEMA6B FLT4 ST6GALNAC3 SYNE1	5.39e-05	196	92	5	48b4a9cea97a55190217deaf51bf867608c5a9a7
Drug	ponatinib	EPHB4 JAK1 FLT4 EPHA2 NTRK3 EPHA4	2.37e-07	68	87	6	ctd:C545373
Drug	5-trifluoromethyl-2'-deoxycytidine	TYMS PYGL CDA	5.36e-07	5	87	3	CID000125618
Drug	2'-deoxytetrahydrouridine	TYMS CDA RRM1	6.34e-06	10	87	3	CID000161730
Drug	Pheniramine maleate [132-20-7]; Up 200; 11.2uM; MCF7; HT_HG-U133A	KLHL29 CRYGC ZSCAN32 ANGPTL2 CDC42BPA PER3 ACAD10	1.06e-05	197	87	7	4130_UP
Drug	tetrahydrouridine	TYMS PYGL CDA RRM1	1.33e-05	38	87	4	CID000029243
Drug	HEPES	DXO FLT4 CROT MTOR CST4 C9	1.38e-05	136	87	6	CID000023830
Drug	cytidine analog	TYMS PYGL CDA	1.90e-05	14	87	3	CID000469095
Drug	DFC-28	EPHB4 EPHA2 EPHA4	1.90e-05	14	87	3	CID005743054
Drug	2-deoxy-D-ribose-1-phosphate	TYMS PYGL CDA RRM1	2.19e-05	43	87	4	CID000000634
Drug	norfloxacin	CFH CRYGC PLCXD1 NKRF	2.63e-05	45	87	4	CID000004539
Drug	motesanib	FLT4 MTOR TG	3.53e-05	17	87	3	CID011667893
Drug	vandetanib	EPHB4 FLT4 MTOR EPHA2 EPHA4	3.91e-05	99	87	5	CID003081361
Drug	imatinib	EPHB4 JAK1 FLT4 MTOR EPHA2 NTRK3 INSRR APLP1 EPHA4	3.93e-05	430	87	9	CID000005291
Drug	Gemcitabine	TYMS RRM1	4.32e-05	3	87	2	DB00441
Drug	diethyl N-(4-aminobenzoyl)-L-glutamate	TYMS SYNE1	4.32e-05	3	87	2	CID000073002
Drug	10-propargylaminopterin	TYMS SYNE1	4.32e-05	3	87	2	CID000100093
Drug	dipropargyl	TYMS SYNE1	4.32e-05	3	87	2	CID000069402
Drug	dibromobimane	TYMS CRYGC CRYGS	5.00e-05	19	87	3	CID000125708
Drug	1,2-dithiolane	TYMS LIPT1 DLAT	5.00e-05	19	87	3	CID000079045
Drug	acyclonucleoside	TYMS PYGL RRM1	5.86e-05	20	87	3	CID000466144
Drug	5-fluoropyrimidine	TYMS PYGL CDA	5.86e-05	20	87	3	CID000069605
Drug	AC1NAQNU	CRYGC MTOR SYNE1	6.82e-05	21	87	3	CID004456135
Drug	AC1NDNTH	TYMS CRYGC CRYGS MTOR TBL3 TG	6.88e-05	181	87	6	CID004604180
Drug	galocitabine	PYGL CDA	8.62e-05	4	87	2	CID000065950
Drug	AC1L2PB2	CROT ACAD10	8.62e-05	4	87	2	CID000125849
Drug	6-thio-octanoate	LIPT1 DLAT	8.62e-05	4	87	2	CID000656431
Drug	N-acetyl-3-hydroxykynurenine	CRYGC CRYGS	8.62e-05	4	87	2	CID000128871
Drug	5-hydroxymethyl-dCMP	TYMS RRM1	8.62e-05	4	87	2	CID000440189
Drug	isofolic acid	TYMS SYNE1	8.62e-05	4	87	2	CID000191247
Drug	CldU	TYMS CDA RRM1	9.03e-05	23	87	3	CID000065510
Drug	5-fluoro-2'-deoxycytidine	TYMS PYGL CDA	1.03e-04	24	87	3	CID000025197
Drug	5-fluorouridylate	TYMS PYGL CDA	1.03e-04	24	87	3	CID000150856
Drug	ICR-191	TYMS JAK1 SMTN	1.03e-04	24	87	3	CID000028240
Drug	Beta-sistosterol [83-46-5]; Down 200; 9.6uM; PC3; HT_HG-U133A	SELL CDC42BPA TECPR2 SYNE1 ASTN1 TNPO3	1.04e-04	195	87	6	4073_DN
Drug	Hymecromone [90-33-5]; Up 200; 22.8uM; MCF7; HT_HG-U133A	SEMA6B FZD9 ANGPTL2 TECPR2 SYNE1 CDA	1.07e-04	196	87	6	3383_UP
Drug	Molindone hydrochloride [15622-65-8]; Up 200; 12.8uM; MCF7; HT_HG-U133A	ZSCAN32 NTRK3 APLP1 TMCO3 PLXNA2 SMTN	1.07e-04	196	87	6	7337_UP
Drug	liu	ADAMTS12 TYMS SEMA6B GUCA1B GUCY2F MTOR RRM1	1.11e-04	285	87	7	CID015991562
Drug	Trapidil [15421-84-8]; Down 200; 19.4uM; MCF7; HT_HG-U133A	EPHB4 FLT4 CDC42BPA EPHA2 APLP1 SMTN	1.13e-04	198	87	6	6515_DN
Drug	orotic acid	TYMS PYGL CDA ACAD10 RRM1	1.14e-04	124	87	5	CID000000967
Drug	Cefmetazole sodium salt [56796-39-5]; Up 200; 8.2uM; MCF7; HT_HG-U133A	ADAMTS12 ZSCAN32 PER3 SYNE1 SIT1 PLXNA2	1.16e-04	199	87	6	7222_UP
Drug	VX-745	EPHB4 EPHA2 EPHA4	1.17e-04	25	87	3	CID003038525
Drug	lometrexol	TYMS UBR5 SYNE1	1.17e-04	25	87	3	CID000001773
Drug	Corynanthine hydrochloride [66634-44-4]; Up 200; 10.2uM; PC3; HT_HG-U133A	CFH CRYGC C22orf31 SLC26A4 SIT1 EPHA4	1.19e-04	200	87	6	4227_UP
Drug	AC1L98C0	TYMS PYGL CDA RRM1	1.20e-04	66	87	4	CID000439930
Drug	ferrocenium hexafluorophosphate	SYNE1 ACAD10	1.43e-04	5	87	2	CID011727263
Drug	bruceine	TYMS RRM1	1.43e-04	5	87	2	CID000122785
Disease	n-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase measurement	CFH NAGPA	8.20e-06	2	85	2	EFO_0801816
Disease	goiter (is_implicated_in)	SLC26A4 TG	8.20e-06	2	85	2	DOID:12176 (is_implicated_in)
Disease	Metastatic melanoma	EPHB4 FLT4 MTOR EPHA4	1.82e-05	54	85	4	C0278883
Disease	cytochrome C measurement	CFH SEMA6B	2.46e-05	3	85	2	EFO_0020302
Disease	lactic acidosis (implicated_via_orthology)	DLAT PYGL	8.15e-05	5	85	2	DOID:3650 (implicated_via_orthology)
Disease	semaphorin-6B measurement	CFH SEMA6B	8.15e-05	5	85	2	EFO_0021885
Disease	galectin-1 measurement	CFH C1R	8.15e-05	5	85	2	EFO_0020932
Disease	Complement deficiency disease	CFH C1R C9	1.18e-04	33	85	3	C0272242
Disease	amyloid beta A4 precursor protein-binding family B member 2 measurement	CFH C1R	1.22e-04	6	85	2	EFO_0801379
Disease	Goiter	SLC26A4 TG	1.71e-04	7	85	2	C0018021
Disease	clusterin measurement	CFH C1R	1.71e-04	7	85	2	EFO_0007655
Disease	r-spondin-3 measurement	CFH C1R	1.71e-04	7	85	2	EFO_0021878
Disease	cystatin-SN measurement	CST2 CST4	2.91e-04	9	85	2	EFO_0008106
Disease	Gastric Adenocarcinoma	EPHB4 EPHA2 NTRK3	3.00e-04	45	85	3	C0278701
Disease	Adenocarcinoma of lung (disorder)	TYMS GUCY2F NTRK3 INSRR RRM1	3.29e-04	206	85	5	C0152013
Disease	f-box/LRR-repeat protein 4 measurement	CFH C1R	3.64e-04	10	85	2	EFO_0802538
Disease	Liver carcinoma	TYMS COL15A1 MTOR HJURP PYGL C9 RRM1	6.60e-04	507	85	7	C2239176
Disease	alkaline phosphatase measurement	JAK1 FZD9 SLC26A4 MACF1 PYGL CHPF2 CDA ACAD10 TRIM6 PKD1L3	6.72e-04	1015	85	10	EFO_0004533
Disease	atrophic macular degeneration, age-related macular degeneration, wet macular degeneration	CFH ACAD10 C9	7.01e-04	60	85	3	EFO_0001365, EFO_0004683, EFO_1001492
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	DNHD1 FLT4 MTOR RYR1	8.98e-04	148	85	4	C0279702
Disease	Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	UBR5 MTOR	9.59e-04	16	85	2	C0334634
Disease	Malignant neoplasm of breast	TYMS EPHB4 PER3 SEMA5B GUCY2F MTOR SYNE1 CST4 MACF1 CDA	1.03e-03	1074	85	10	C0006142
Disease	Antibody Deficiency Syndrome	CFH C9	1.08e-03	17	85	2	C0003257
Disease	cystatin-D measurement	CST2 CST4	1.08e-03	17	85	2	EFO_0008103
Disease	Nuclear non-senile cataract	CRYGC EPHA2	1.22e-03	18	85	2	C1112705
Disease	Nuclear cataract	CRYGC EPHA2	1.22e-03	18	85	2	C0392557
Disease	Age-related macular degeneration	CFH C9	1.22e-03	18	85	2	cv:C0242383
Disease	Carcinoma of bladder	MTOR EPHA4	1.22e-03	18	85	2	C0699885
Disease	polycystic kidney disease (biomarker_via_orthology)	MTOR C9	1.36e-03	19	85	2	DOID:0080322 (biomarker_via_orthology)
Disease	Immunologic Deficiency Syndromes	CFH C9	1.99e-03	23	85	2	C0021051
Disease	Sensorineural Hearing Loss (disorder)	DMXL2 SLC26A4	1.99e-03	23	85	2	C0018784
Disease	Pseudoaphakia	CRYGC CRYGS	2.17e-03	24	85	2	C0524524
Disease	Lens Opacities	CRYGC CRYGS	2.17e-03	24	85	2	C1510497
Disease	Limb-girdle muscular dystrophy	TCAP TNPO3	2.55e-03	26	85	2	cv:C0686353

Protein segments in the cluster

Peptide	Gene	Start	Entry
QRRNLCEWMRKPAQQ	CDX2	161	Q99626
CEWMRKPAQQSLGSQ	CDX2	166	Q99626
SLCPQMLQGSSWREQ	CARMIL2	821	Q6F5E8
RVEQATQAIPMERWC	APLP1	106	P51693
MCVRSCFQSPRLQWV	ACAD10	1	Q6JQN1
WMARTCAKQNINAPA	C22orf31	41	O95567
NVRMQSPKQRTSRCW	GCSAM	21	Q8N6F7
PENTNRLMQVWCDQR	ANGPTL2	296	Q9UKU9
NNRTGCQMLLDNPWK	ANKRD55	481	Q3KP44
RWDPEVNCSMAQIQL	CFH	796	P08603
SVRMFEWTRPQQLVC	DMXL2	2786	Q8TDJ6
DQLWASLSNPRAAMQ	DNHD1	4301	Q96M86
NPQACENWLRGKNRM	C1R	616	P00736
QQNSSGPWAMDLCAR	ASTN1	451	O14525
MPCAQRSWLANLSVV	ADAMTS12	1	P58397
NQPRRMCLPDSWAMN	HJURP	451	Q8NCD3
QLMRKCWEFQPSNRT	JAK1	1126	P23458
EMAQRHLQRSLCPWV	DAOA	71	P59103
DRRQPLERMWTCNYN	DAOA	121	P59103
WLRGARCDIQMTQSP	IGKV1D-39	16	P04432
QLMLDCWQKDRNARP	EPHB4	851	P54760
DVMLGCWQREPQQRL	NTRK3	801	Q16288
RHQNPWQECNLNLMR	LIPT1	76	Q9Y234
QVCNVMEPSQNNWLR	EPHA4	71	P54764
RDATLFCEPWTLNMQ	PER3	646	P56645
MCSRRDKCQQAWEPN	PLXNA2	536	O75051
MWRVCARRAQNVAPW	DLAT	1	P10515
RMALCAPADQSQSWA	INTS2	51	Q9H0H0
KPMNWQRARRFCRDN	SELL	46	P14151
ASCPSLPDQNNMWIR	MEIS3	191	Q99687
LPDVRQACLQMAISW	ALOX12	581	P18054
CRNANEDWMSALCPR	PLCXD1	16	Q9NUJ7
RNDRDGWNPSVCMNF	DXO	316	O77932
CFQAAESQLRPWLME	MACF1	4581	Q9UPN3
LNMDFWRLRATEQPC	FZD9	471	O00144
QRWMGLNDRLSSCRA	CRYGS	71	P22914
MQCWQQERARRPKFA	EPHA2	851	P29317
QLMKQCWAEAAEQRP	GUCY2F	786	P51841
NQPGLNMCKRDRVSW	HEPHL1	631	Q6MZM0
GCPLQLQELMSRCWQ	INSRR	1216	P14616
WLRGARCDIQMTQSP	IGKV1-39	16	P01597
RMWQLVTCQESCQPS	KRTAP29-1	41	A8MX34
LRPQEYRRCQDWGAM	CRYGC	146	P07315
SLWNCVRQMNGTLRS	EMILIN2	736	Q9BXX0
PWEDRMSLVNSRCQE	CST2	126	P09228
MAPRRNNGQCWCLLM	COL15A1	1	P39059
PWEDRMSLVNSRCQE	CST4	126	P01036
QTLWNMNPICSRCEE	RYR1	196	P21817
QNGECPWQVSIQMSR	PRSS51	46	A0A1B0GVH4
INQLSRNMICAWNEP	PRSS51	161	A0A1B0GVH4
WSQCDPCLRQMFRSR	C9	51	P02748
EAVRWCQSMQDPSVN	CROT	461	Q9UKG9
MNPRLCQQLASISWL	OR2G3	136	Q8NGZ4
RSCWALAQAYNPMAR	MTOR	1301	P42345
MASPQLCRALVSAQW	MPST	1	P25325
FQKDLMANIRCRPWT	TMC3	56	Q7Z5M5
VAAMQSRQWVRDSCR	TMCO3	41	Q6UWJ1
QDRLSQMNGRWDRVC	SYNE1	8521	Q8NF91
MPNRTWRCRVFLQDH	NKRF	371	O15226
QMDMNPSSWLAQQRR	GUCA1B	181	Q9UMX6
HCQDNMWRCPRQVST	NAGPA	306	Q9UK23
PWNQFTRVQRLSCCM	PKD1L3	896	Q7Z443
NEIDRSSCIWRMNNA	ST6GALNAC3	96	Q8NDV1
AVNWMLQQECFRSSP	SHPRH	311	Q149N8
QCQVLVQRSPWLMMR	TCAP	56	O15273
CQGRRSRQQELMWPA	CDC42BPA	1436	Q5VT25
SRQQELMWPANPSSC	CDC42BPA	1441	Q5VT25
AQTGECSSMPLQWNR	EXTL1	141	Q92935
PMVRQRQQDLQTAWS	SPTBN5	1806	Q9NRC6
CSVTVPANVQRWMRS	AIMP2	291	Q13155
PANVQRWMRSCENLA	AIMP2	296	Q13155
RWMRSCENLAPFNTA	AIMP2	301	Q13155
ACRQVMREFGTNWPV	CDA	101	P32320
PEVLNRCRMNAISGW	CHPF2	601	Q9P2E5
WRSNPSDINVCRMKG	SEMA6B	106	Q9H3T3
NRAVSLCQQEWMCPG	ZSCAN32	216	Q9NX65
MFMQLCDIPRLWRQN	SLC26A4	461	O43511
RVETNQDWSLMCPNE	RRM1	341	P23921
RRGLWCVQFSPMDQV	TBL3	521	Q12788
MLQQFIRPWCTSLRN	TNPO2	796	O14787
RRQQQDLMPQCRDWR	FLT4	476	P35916
DLMPQCRDWRAVTTQ	FLT4	481	P35916
NPDDRRIIMCAWNPR	TYMS	171	P04818
RMAFWSQQLQCQPSL	TECPR2	1066	O15040
MSLWTQNITACPVRN	SEMA5B	591	Q9P283
LQDSAAWLREMNCPE	POGLUT2	141	Q6UW63
NVNWARRSECNMCNT	ZRANB2	76	O95218
MQVDRPTFCRWLENS	TNPO3	861	Q9Y5L0
SQQPVGEAMVCRRWQ	ZSWIM3	571	Q96MP5
IFEDCRNQWSMSRPL	XPO7	991	Q9UIA9
LAVNENCMRPSWSLS	USP31	856	Q70CQ4
NNTVNTMRLWSARAP	PYGL	236	P06737
AMQQCQLLCRQGSWS	TG	1241	P01266
PNANSIKQMLLDWCR	SMTN	796	P53814
MNQADPRLRAVCLWT	SIT1	1	Q9Y3P8
NIVTQWQPRNCDPMV	TFIP11	491	Q9UBB9
SWKNQMEPERCRIQT	TRIM6	171	Q9C030
WNMNDSCRFQLRSPE	UBR5	566	O95071
DNWNLVSRMTVPRCR	KLHL29	661	Q96CT2